Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 219803769

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|219803769 trichoplein [Homo sapiens]
         (498 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|219803769 trichoplein [Homo sapiens]                               971   0.0  
gi|14150056 trichoplein [Homo sapiens]                                971   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              145   6e-35
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   133   4e-31
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   132   1e-30
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   130   2e-30
gi|94721321 coiled-coil domain containing 11 [Homo sapiens]           129   5e-30
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       126   5e-29
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       126   5e-29
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        126   5e-29
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        126   5e-29
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        126   5e-29
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        126   5e-29
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        126   5e-29
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        126   5e-29
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   123   3e-28
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   123   4e-28
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...   107   3e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   105   7e-23
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...   102   1e-21
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...   100   5e-21
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...   100   5e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    97   3e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    97   3e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    97   3e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    97   3e-20
gi|21735548 centrosomal protein 2 [Homo sapiens]                       96   1e-19
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]          95   2e-19
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    94   3e-19
gi|44890059 involucrin [Homo sapiens]                                  93   5e-19

>gi|219803769 trichoplein [Homo sapiens]
          Length = 498

 Score =  971 bits (2510), Expect = 0.0
 Identities = 498/498 (100%), Positives = 498/498 (100%)

Query: 1   MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
           MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY
Sbjct: 1   MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
           QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH
Sbjct: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120

Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180

Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
           EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE
Sbjct: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240

Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
           QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300

Query: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
           QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360

Query: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
           REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420

Query: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
           REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM
Sbjct: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480

Query: 481 AEQGYRPKPYGHPKIAWN 498
           AEQGYRPKPYGHPKIAWN
Sbjct: 481 AEQGYRPKPYGHPKIAWN 498


>gi|14150056 trichoplein [Homo sapiens]
          Length = 498

 Score =  971 bits (2510), Expect = 0.0
 Identities = 498/498 (100%), Positives = 498/498 (100%)

Query: 1   MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60
           MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY
Sbjct: 1   MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY 60

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
           QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH
Sbjct: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120

Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA
Sbjct: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180

Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
           EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE
Sbjct: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240

Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
           QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300

Query: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
           QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360

Query: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420
           REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR 420

Query: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
           REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM
Sbjct: 421 REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480

Query: 481 AEQGYRPKPYGHPKIAWN 498
           AEQGYRPKPYGHPKIAWN
Sbjct: 481 AEQGYRPKPYGHPKIAWN 498


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  145 bits (367), Expect = 6e-35
 Identities = 129/497 (25%), Positives = 243/497 (48%), Gaps = 52/497 (10%)

Query: 22  RQREQEARLRQQWEQNSRYFRMSDICSSKQAE--WSSKTSYQRSMHAYQREKMKEEKRRS 79
           +++EQE  L +  EQ+ +  R+      ++ E  W  +  +Q      +RE+ + E+ + 
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQ------EREERRAEEEQL 193

Query: 80  LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLL 139
              +  +  +   EEQ L  REL ELR       R+ RE+  K +  +E Q ++  E+  
Sbjct: 194 QSCKGHETEEFPDEEQ-LRRRELLELR-------RKGREE--KQQQRRERQDRVFQEEEE 243

Query: 140 YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEE------------KKQQEATAEQENKRY 187
            E W+K    LR+ E  L ++      E+Q+EE            +++QE   +Q+  R 
Sbjct: 244 KE-WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302

Query: 188 ENE----YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQEN 243
           E +     E  RRE  E  + ++ERR+ +++ + + L ++ EE + +++   + ++ +E 
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ 362

Query: 244 LLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRR 298
            L++  E ER E++ ++ +  R++ +L R  + +   QL      RR QQ++ E +  RR
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL-RR 421

Query: 299 ILQALLEKEDE--SQRLHLARREQVMADVA-----WMKQAIEEQLQLERAREAELQMLLR 351
             Q   E+E+E   Q+    RREQ +         W+K+  E +   +  R+ +L+    
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481

Query: 352 EEAKEMWEKREAEWARERSAR--DRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLI 409
           EE +E W K E E  RE+  R   +L  E    R+Q+++ + E+ R  Q   L+  +QL 
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR--LRSEQQLR 539

Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
           R  EE RE   + +EE    +  R+Q L+ +  ERR Q  + +++  ++  +  + E+L 
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599

Query: 470 DALLQQEAETMAEQGYR 486
             L ++E E + ++  R
Sbjct: 600 QRLKREEVERLEQEERR 616



 Score =  139 bits (351), Expect = 5e-33
 Identities = 139/503 (27%), Positives = 239/503 (47%), Gaps = 39/503 (7%)

Query: 13  QQRLNQQLARQ----REQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
           ++R  QQL R+    REQ+ R  QQ  +  +  R   +   +Q     +   ++ +   Q
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 429

Query: 69  REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL--------QERRIREQH 120
            E+  E+K    E R ++L++  +E +D L RE E  R             QE   RE+ 
Sbjct: 430 EEERHEQKHEQ-ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 121 GKLKSA-KEEQRKLIAEQLLYEHWKKNNPKL-REMELDLHQKHVVNSWEMQKE-EKKQQE 177
            KL+   + EQ++   +QL  E  ++   +L R+ E +  Q+ + +  ++++E E+++++
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 178 ATAEQENKRYENEY--ERARREALER----MKAEEERRQLEDKLQAEALLQQMEELKLKE 231
               +E KR E E   +R +RE  ER    +K EEERRQ   K + E  L+Q   LK +E
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ--RLKREE 606

Query: 232 VEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQE 291
           VE    + EQE   +QR + E  EEER+Q +  + + +  R  +     Q  RR Q+++ 
Sbjct: 607 VE----RLEQEERREQRLKREEPEEERRQ-QLLKSEEQEERRQQQLRREQQERREQRLKR 661

Query: 292 ELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR 351
           E E +R   +   E E+E +   LA  EQ  A      +  + Q QLE   +A    +  
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721

Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNR------RAQEESLKHR 405
              K+  ++R  E   +R  R+  +      R  + Q++ EQ R      +A+E+S + R
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781

Query: 406 EQLIRN--LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEAR 463
           ++L     L E RE   R +E  ++ +    +E E +   R+ +  E + Q  EEEE+ +
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841

Query: 464 RVEQLSDALLQQEAETMAEQGYR 486
           R E+     LQ+E + + E   R
Sbjct: 842 RRERAQQ--LQEEEDGLQEDQER 862



 Score =  138 bits (347), Expect = 1e-32
 Identities = 125/507 (24%), Positives = 239/507 (47%), Gaps = 43/507 (8%)

Query: 18  QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
           ++L  +  Q  R  Q+ E+  R     ++   +Q E   +   +R      R K +EE+R
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL--RRKQEEERR 315

Query: 78  RSLEARREKLRQLMQEEQ---DLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
              E RRE+  +  Q+E+     L RE EE R     +E+    +  +L+  +EE+R+  
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR-- 373

Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEE--------KKQQEATAEQENKR 186
            +QL  E   +   +LR  +    ++ +    ++++E+        +++Q+   EQE +R
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 187 YENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
           +E ++E+ RRE  +R+K E+E R+  D L+ E   ++ E+ + K+    +LK++QE   +
Sbjct: 434 HEQKHEQERRE--QRLKREQEERR--DWLKREEETERHEQERRKQ----QLKRDQEEERR 485

Query: 247 QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE- 305
           +RW     EE R+Q E   Q+    +  R +   +     +++Q+ L +++++ +   E 
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 306 -----KEDESQRLHLARREQVMA-------DVAWMKQAIEEQLQLERAREAEL-QMLLRE 352
                K +E +RL   RREQ +        D    ++    Q +L+R +E  L Q L RE
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605

Query: 353 EAK--EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIR 410
           E +  E  E+RE    RE    +R   + L   ++Q + + +Q RR Q+E  +  ++L R
Sbjct: 606 EVERLEQEERREQRLKREEPEEER--RQQLLKSEEQEERRQQQLRREQQE--RREQRLKR 661

Query: 411 NLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
             EE R   R ++E  E+ +     E E + A  R+++     Q + E E   R  ++  
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721

Query: 471 ALLQQEAETMAEQGYRPKPYGHPKIAW 497
              +QE +   ++    +     ++ W
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQW 748



 Score =  137 bits (344), Expect = 3e-32
 Identities = 136/526 (25%), Positives = 251/526 (47%), Gaps = 56/526 (10%)

Query: 13   QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
            ++R  Q+  RQ  ++ +L+Q+ EQ             ++ ++  +   Q+      RE+ 
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE---- 128
            ++ +R+  E +  K  +L QEE+ LL  E E+ RL    +ER+ RE+  +L+  +E    
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEE-ELQQEEEQLLG 1065

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
            E+R+    Q L   ++K     +E E  L ++      + ++ + +++E   ++E +   
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125

Query: 189  NEYERARREALERMKAEEERRQLEDK--LQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
             E E+ RR+ LER   EEE  Q E++  L+ E   ++ +EL+ +  E  +L++E+E LL+
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185

Query: 247  QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRT-------------------- 286
            +  E  R E ER+    +R++ EL R  R Q      +R+                    
Sbjct: 1186 EEQEKRRQERERQ----YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 287  ---------QQIQEELEADRRI---LQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
                     +Q+++    DR+    LQ LL ++ E  R    RR Q   D  + +   EE
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ-QRDRHFPE---EE 1297

Query: 335  QLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSE---VLTGRQQQIQEKI 391
            QL+ E  +EA+ +    +E K++  + E E  R R   DR   E   +L  R++Q   + 
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLL-REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356

Query: 392  EQNRRAQEESLKHREQLIRNLEEVRELARREKEES--EKLKSARKQELEAQVAERRLQAW 449
            E++R+ +EE L+H+EQ  + LEE + L R+E+E    ++ +  R QE E Q+ + R + +
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416

Query: 450  -EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPK 494
             E +QQ   +E + +  E+      Q+      E+  + +   H K
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462



 Score =  135 bits (341), Expect = 7e-32
 Identities = 123/454 (27%), Positives = 221/454 (48%), Gaps = 36/454 (7%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
           K+A    K S  +     + ++  E + R LE    + R+  ++EQ+    E EE     
Sbjct: 99  KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158

Query: 110 NLQERRIR----EQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNS 165
              E+R R    E+  + +   +E+ +  AE+   +  K +  +    E  L ++ ++  
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218

Query: 166 WEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
               +EEK+QQ    E++++ ++ E E+  R+    ++ EEE+ Q E++ Q +  LQ+ E
Sbjct: 219 RRKGREEKQQQR--RERQDRVFQEEEEKEWRKRETVLRKEEEKLQ-EEEPQRQRELQEEE 275

Query: 226 ELKLKEVEATKLKKEQENLLKQRWELERLEE-ERKQMEAFRQKAELGRFLRHQYNAQLSR 284
           E +L+++E  +L++E++   +Q+  L R ++  RKQ E  R++ E  R  + +   Q  R
Sbjct: 276 E-QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334

Query: 285 RTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA 344
           R QQ++ E E  R   Q L  +++E +R    RREQ   +    +Q +  + QL R ++ 
Sbjct: 335 REQQLRREQEERRE--QQLRREQEEERREQQLRREQ---EEERREQQLRREQQLRREQQL 389

Query: 345 ELQMLLREE---AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
             +  LR E    +E   +RE +  RE+  R          R+QQ++ + E+ R  Q+  
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLR----------REQQLRREQEEERHEQKHE 439

Query: 402 LKHREQ-LIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
            + REQ L R  EE R+  +RE+E     +  RKQ+L+    E R + W   ++EE  E+
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 461 EARRVEQL--------SDALLQQEAETMAEQGYR 486
           + RR +QL           L +QE E   +Q  R
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLR 533



 Score =  131 bits (329), Expect = 2e-30
 Identities = 131/495 (26%), Positives = 229/495 (46%), Gaps = 60/495 (12%)

Query: 10   WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
            W  ++R ++Q  ++ EQ      QW+   +  R     S++      +    R+    QR
Sbjct: 748  WQEEERAHRQ-QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806

Query: 70   EKM------KEEKRRSLEARREKLRQLMQEEQDLLAREL------EELRLSMNLQERRIR 117
            E+       ++E+RR     REK  Q ++EE+ L  RE       EE  L  + + RR +
Sbjct: 807  EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866

Query: 118  EQHG--KLKSAKEEQRK-----LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQK 170
            EQ    K +   EE+RK     L A+  L E  +K    L+E E +L ++      E +K
Sbjct: 867  EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE------EREK 920

Query: 171  EEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLK 230
              +++QE    +E +  + E +  R E  +R + E ER+  +DK      LQQ EE  L 
Sbjct: 921  RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK-----LQQKEEQLLG 975

Query: 231  EVEATKLKKEQENLLKQRWELERLEEE--------RKQME---AFRQKAELGRFLRHQYN 279
            E    + ++E+E   ++  EL++ EE+        R++ E    +R+K EL      Q  
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL-----QQEE 1030

Query: 280  AQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLE 339
             QL R  ++ +   E +R+  +    +++E Q L   R  +        +Q +E Q + E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR-------RRQELERQYRKE 1083

Query: 340  RAREAELQMLLREE-AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ 398
               + E + LLREE  K   ++RE +   E   +      +   R+++ ++++E+  R +
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143

Query: 399  EESLKHREQLIRNLEEVR---ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQE 455
            EE  +  EQL+R   E R   EL R+ +EE E      +++L  +  E+R Q  E   +E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 456  EEEEEEARRVEQLSD 470
            EEE +  +R ++  D
Sbjct: 1202 EEELQRQKRKQRYRD 1216



 Score =  130 bits (328), Expect = 2e-30
 Identities = 143/558 (25%), Positives = 243/558 (43%), Gaps = 92/558 (16%)

Query: 13  QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSS-----KQAEWSSKTSYQRSMHAY 67
           Q R  QQL R++E+E R  Q+ EQ  R  R+           K+ E + +   +R     
Sbjct: 418 QLRREQQLRREQEEE-RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476

Query: 68  QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELR---LSMNLQERRIREQHGKLK 124
           +R++ +E + R L+   E+ R+  +  +  L RE EE R   L    +E R++++    +
Sbjct: 477 KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536

Query: 125 SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
             + EQ +   + L  E  K+   + RE  L   Q+   +    ++EE++QQ    EQE 
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596

Query: 185 KRYEN---------EYERARREALERMKAEEERRQ--LEDKLQAEALLQQMEELKLKEVE 233
           +  +          E E  R + L+R + EEERRQ  L+ + Q E   QQ+   + +  E
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656

Query: 234 ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF------------LRHQYNAQ 281
               ++E+E  L+QR + E  EEER++ E   ++ E  R             L  + +A+
Sbjct: 657 QRLKREEEEERLEQRLKREH-EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715

Query: 282 LSR--------RTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIE 333
            S+          Q+ ++E E  RR  ++ L+ ++E +     + E+   D  W  QA E
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775

Query: 334 E--------------------QLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
           +                    QL+ E  ++ E + L  EE KE   ++  E  +E    +
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835

Query: 374 RLMSEVLTGRQQQIQE------KIEQNRRAQ------------EESLKHREQLIRNLEEV 415
                    R QQ+QE      + ++ RR+Q            EE  K R   +     +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895

Query: 416 RELARRE----KEESEKLKSARKQELEAQVAERRLQAWEADQQEEE----EEEEARRVEQ 467
           +E  R+E    +EE E+L+   +++   Q  ER+ +  E  QQEEE    EE E RR ++
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 468 -----LSDALLQQEAETM 480
                  D  LQQ+ E +
Sbjct: 956 RERQYRKDKKLQQKEEQL 973



 Score =  130 bits (326), Expect = 4e-30
 Identities = 136/489 (27%), Positives = 241/489 (49%), Gaps = 59/489 (12%)

Query: 13  QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
           ++   +Q   +REQ+ R  QQ E+  +  R       ++ E   +   +      Q  + 
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQ---EERREQQLRREQEEERREQQLRRE 367

Query: 73  KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR-EQHGKLKSAKEEQR 131
           +EE+RR  + RRE+  QL +E+Q  L RE +  R     +E+++R EQ  + +     ++
Sbjct: 368 QEEERREQQLRREQ--QLRREQQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 423

Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
           +L  EQ    H +K+  + RE  L   Q+     W  ++EE ++ E   E+  ++ + + 
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEER-RDWLKREEETERHEQ--ERRKQQLKRDQ 480

Query: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
           E  RRE   +++ EE R Q E + Q                   +L++EQE   +QR  L
Sbjct: 481 EEERRERWLKLEEEERREQQERREQ-------------------QLRREQEERREQR--L 519

Query: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQ 311
           +R EEE +  +  R + +L R  + +   QL +R +  ++ LE +RR  +  L++E E +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRR-EQEERREQLLKREE--EKRLEQERR--EQRLKREQEER 574

Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA 371
           R  L +RE+       +K+  EE+L+ +R +  E++ L +EE +E   KRE E   ER  
Sbjct: 575 RDQLLKREEERRQQR-LKREQEERLE-QRLKREEVERLEQEERREQRLKRE-EPEEERRQ 631

Query: 372 RDRLMSEVLTGRQQQI----QEKIEQNRRAQEESLKHREQLIRNLEEVR---ELARREKE 424
           +     E    RQQQ+    QE+ EQ  + +EE  +  ++L R  EE R   ELA  E+E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 425 ES-EKLKSARKQ---ELEAQVAERRLQAW------EADQQEEEEEEEARRVEQLSDALLQ 474
           ++ E++KS   +   +LE++   R+ + +      E  ++ +E+EE+ RR E  S+   Q
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQ 749

Query: 475 QEAETMAEQ 483
           +E     +Q
Sbjct: 750 EEERAHRQQ 758



 Score =  129 bits (324), Expect = 6e-30
 Identities = 136/493 (27%), Positives = 232/493 (47%), Gaps = 71/493 (14%)

Query: 13   QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
            Q+    QL ++ E+  + R + EQ  R  +       K+ E       +R     +RE+ 
Sbjct: 571  QEERRDQLLKREEERRQQRLKREQEERLEQRL-----KREEVERLEQEERREQRLKREEP 625

Query: 73   KEEKRRSL-------EARREKLRQLMQEEQDL-LARELEELRLSMNLQERRIREQHGKLK 124
            +EE+R+ L       E R+++LR+  QE ++  L RE EE RL   L+ R   E+  + +
Sbjct: 626  EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK-REHEEERREQE 684

Query: 125  SAKEEQRKLIAEQLLYEHWKKNNPKLR---EMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
             A+EEQ +        E  K   PK +   E E D  Q  V +    Q+ ++++QE   E
Sbjct: 685  LAEEEQEQA------RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ--E 736

Query: 182  QENKRYENEYERARREALERMKAEEE-RRQLEDKLQAEALLQQMEEL-----KLKEVEAT 235
            ++ +R E+E +    E   R + EEE RR    + QAE   ++  +       L+E    
Sbjct: 737  EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER 796

Query: 236  KLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE--- 292
            +L+ E+    +QR+  E  E+E+++ +   ++ EL +FL  +   Q   R QQ+QEE   
Sbjct: 797  QLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQLQRRERAQQLQEEEDG 855

Query: 293  LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
            L+ D+   ++  ++ D+  R  L    +      + K A++EQL+ E       Q LL+E
Sbjct: 856  LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE-------QQLLQE 908

Query: 353  EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNL 412
            E +E+ ++ E E  R               RQ+Q ++  E+ +  QEE     EQL+R  
Sbjct: 909  EEEEL-QREEREKRR---------------RQEQERQYREEEQLQQEE-----EQLLREE 947

Query: 413  EEVRELARREKE--ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
             E R    RE++  + +KL+   +Q L  +  +RR Q  E   +EEEE      ++Q  +
Sbjct: 948  REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE------LQQEEE 1001

Query: 471  ALLQQEAETMAEQ 483
             LL++E E    Q
Sbjct: 1002 QLLREEREKRRRQ 1014



 Score =  127 bits (318), Expect = 3e-29
 Identities = 133/514 (25%), Positives = 233/514 (45%), Gaps = 57/514 (11%)

Query: 13   QQRLNQQLARQREQEARLRQQWEQNSRYFRMS----------DICSSKQAEWSSKTSYQR 62
            ++RL Q+L R+ E+E R ++  E+     R             + S   A  S   S  R
Sbjct: 665  EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 63   SMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERR------- 115
                 +R + +EEKRR    RRE   Q  +EE+    ++ EE R     Q +        
Sbjct: 725  KQEGQRRRQEQEEKRR----RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780

Query: 116  ---------IREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSW 166
                     +REQ  +   A+E Q++   ++ L E  +K   + +  E +   + +    
Sbjct: 781  RQRLSARPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838

Query: 167  EMQKEEKKQQ---EATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQ 223
            ++Q+ E+ QQ   E    QE++      E+ RR+   R + EEER++    L A+  LQ+
Sbjct: 839  QLQRRERAQQLQEEEDGLQEDQERRRSQEQ-RRDQKWRWQLEEERKRRRHTLYAKPALQE 897

Query: 224  M---EELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEA---FRQKAELGRFLRHQ 277
                E+  L+E E    ++E+E   +Q  E +  EEE+ Q E     R++ E  R    +
Sbjct: 898  QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957

Query: 278  YNAQLSRRTQQIQEEL---EADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
               +  ++ QQ +E+L   E ++R  Q   +K  E + L     EQ++ +    ++  E 
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ-QEEEQLLREEREKRRRQEW 1016

Query: 335  QLQLERAREA---ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI 391
            + Q  +  E    E Q+L  E  K   ++RE ++  E   +      +   R+ + ++++
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 392  EQNRRAQEESLKHREQLIRNLEEVRELARREKE--ESEKLKSARKQELEAQVAERRLQAW 449
            E+  R +EE  +  EQL+R   E R    RE++  E E+L+   +Q L  +  +RR Q  
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ-- 1134

Query: 450  EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            E ++Q  EEEE    V+Q  + LL++E E    Q
Sbjct: 1135 ELERQYREEEE----VQQEEEQLLREEPEKRRRQ 1164



 Score =  123 bits (308), Expect = 4e-28
 Identities = 132/556 (23%), Positives = 243/556 (43%), Gaps = 87/556 (15%)

Query: 13   QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
            ++R  Q+  RQ  +E  L+Q+ EQ  R  R        + ++  +   Q+      RE+ 
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEE 129
            ++ +R+ LE +  +  +L QEE+ LL  E E+ R     Q   E  ++ Q  K +   E+
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218

Query: 130  QRKLIAEQLLYEHWKKN-------------NPKLREMELDLHQKHVVNSWEMQKEEKKQQ 176
            QR  +  Q  +E  K+N             N + R++E D   +   +  ++Q    +QQ
Sbjct: 1219 QRSDLKWQ--WEPEKENAVRDNKVYCKGRENEQFRQLE-DSQLRDRQSQQDLQHLLGEQQ 1275

Query: 177  EATAEQENKRYENEYER-ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEAT 235
            E   EQE +R++         E LER + +E +R+     + + LL++  E K +  E  
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335

Query: 236  KLKKEQENLLKQRWE--LERLEEERKQMEAFRQKAELGR-----------------FLRH 276
            +  +E+E LL++R E  L R E +RK  E   +  E GR                 FL+ 
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395

Query: 277  QYNAQLSRRTQQIQEE-------------------------------------LEADRRI 299
            +   +   R QQ++++                                     LE ++++
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455

Query: 300  LQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQL---ERAREAELQMLLREEAKE 356
             Q    K  E ++L   R EQ +      ++ +EE+ QL   ER R+   Q L  +E + 
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER 1515

Query: 357  MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR 416
             + + E +  R++  R  L  E    +Q + QE+ +Q R+ ++   +  EQL +  EE +
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEE----QQLRRQERGQQRRQDRDRKFREEEQLRQEREE-Q 1570

Query: 417  ELARREKEESEKL--KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
            +L+R+E++   +L  +  R+QE E +  E   Q    + Q++  +E  R+  +  + LLQ
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE-DEQLLQ 1629

Query: 475  QEAETMAEQGYRPKPY 490
            +  E    +  R + +
Sbjct: 1630 EREEQQLHRQERDRKF 1645



 Score =  117 bits (293), Expect = 2e-26
 Identities = 122/470 (25%), Positives = 228/470 (48%), Gaps = 51/470 (10%)

Query: 13   QQRLNQQLARQR------EQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHA 66
            Q+R  QQL RQ       E+E +LR+Q  +  R FR  ++ S +      +   Q     
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQ--ERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 67   YQREKMKEEKR-----RSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHG 121
             QR+ ++EE++     R  + R+++ R+  +EEQ  L +E EE +LS   ++R+ R +  
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ--LRQEREEQQLSRQERDRKFRLEEQ 1586

Query: 122  KLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
            K++  ++E++ +  EQ L    ++   +LR+       +      ++ +E ++QQ    E
Sbjct: 1587 KVRRQEQERKFMEDEQQLRR--QEGQQQLRQER----DRKFREDEQLLQEREEQQLHRQE 1640

Query: 182  QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
            ++ K  E E +  R+E  ++++ + +R+  E+    E LLQ+ EE +L+  E  +  +E+
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREE----EQLLQEGEEQQLRRQERDRKFREE 1696

Query: 242  ENLLKQRWELERLEEERKQMEAFRQ--KAELGRFLRHQYNAQLSRRTQQIQ-EELEADRR 298
            E       +L R E ERK ++  +Q  + EL R  R +   QL + T+Q Q    E  R+
Sbjct: 1697 EQ------QLRRQERERKFLQEEQQLRRQELERKFREE--EQLRQETEQEQLRRQERYRK 1748

Query: 299  ILQA-LLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
            IL+   L  E E Q+L    R++   +   ++Q  EEQ    + R  E     REE +  
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ----QLRSQESDRKFREEEQLR 1804

Query: 358  WEKREAEWA-RERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR 416
             E+ E +   ++R  + R   E     Q Q++E+ ++ R+ ++   +  EQ     +  R
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEE-----QLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVE 466
            E     +EE +K    R+QE E ++ E  ++  + ++Q   +  E +  E
Sbjct: 1860 EEQELWQEEEQK----RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905



 Score =  117 bits (292), Expect = 3e-26
 Identities = 126/511 (24%), Positives = 238/511 (46%), Gaps = 63/511 (12%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            QQL+RQ E++ + R++ +Q  R  R       K  E   +   +R     + E++ +E+ 
Sbjct: 1421 QQLSRQ-ERDRKFREEEQQVRRQER-----ERKFLEEEQQLRQERHRKFREEEQLLQERE 1474

Query: 78   RSLEARREKLRQLMQEEQDLLARELE----ELRLSMNLQERRIREQHGKLKSAKEEQRKL 133
                 R+E+ R+ ++EEQ L  +E +    E  L     ER+  E+  +L   + +++ L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534

Query: 134  IAEQLL------YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK-----QQEATAEQ 182
              EQ L       +  +  + K RE E  L Q+        Q+ ++K     Q+    EQ
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEE-QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593

Query: 183  ENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQE 242
            E K  E+E +  R+E  ++++ E +R+  ED    E LLQ+ EE +L   E  +   E+E
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFRED----EQLLQEREEQQLHRQERDRKFLEEE 1649

Query: 243  NLLKQRWELERLEEER----KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
              L+++   ++L  +R    ++ E   Q+ E  +  R + + +     QQ++ + E +R+
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERK 1708

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
             LQ       E Q+L     E+   +   ++Q  E++   +  R+   + +L EE  ++ 
Sbjct: 1709 FLQ-------EEQQLRRQELERKFREEEQLRQETEQE---QLRRQERYRKILEEE--QLR 1756

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQ-LIRNLEEVRE 417
             +RE +  R R  RDR   E     +Q  QE+ EQ  R+QE   K RE+  +R   E ++
Sbjct: 1757 PEREEQQLR-RQERDRKFRE----EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811

Query: 418  LARREKE-----ESEKLKSARKQELEAQVAERRLQAWEA---------DQQEEEEEEEAR 463
            L  ++++     E E+L+   +++   Q  +R+ +A E          ++QE  +EEE +
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871

Query: 464  RVEQLSDALLQQEAETMAEQGYRPKPYGHPK 494
            R ++    L ++      ++  R +  G  K
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQVGEIK 1902



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 82/325 (25%), Positives = 152/325 (46%), Gaps = 55/325 (16%)

Query: 13   QQRLNQQLARQR------EQEARLR-QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
            Q+R  QQL RQ       E+E +LR Q+ EQ  R+ R       ++ E   +   ++ + 
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF---REEEQLLQEGEEQQLR 1685

Query: 66   AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELE-----ELRLSMNLQERRIREQH 120
              +R++   E+ + L  R+E+ R+ +QEEQ L  +ELE     E +L    ++ ++R Q 
Sbjct: 1686 RQERDRKFREEEQQLR-RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744

Query: 121  GKLKSAKEEQ----------------RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVN 164
               K  +EEQ                RK   E+ L +  ++   +LR  E D   +    
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQ--EREEQQLRSQESDRKFREE-- 1800

Query: 165  SWEMQKEEKKQQEATAEQENKRYENEYERARREALE-RMKAEEERRQLEDKLQAEALLQQ 223
              E  ++E+++Q+   +Q + +Y  E E+ + E  E R++ E +R+   ++  A     +
Sbjct: 1801 --EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858

Query: 224  MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAEL--------GRFLR 275
             EE +L + E  K ++E+E  L++    E +  ++K+ +  RQ  E+        GR L 
Sbjct: 1859 REEQELWQEEEQKRRQERERKLRE----EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914

Query: 276  ---HQYNAQLSRRTQQIQEELEADR 297
               HQ+ A +  R+  + E ++  R
Sbjct: 1915 PGTHQF-ASVPVRSSPLYEYIQEQR 1938


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  133 bits (334), Expect = 4e-31
 Identities = 126/504 (25%), Positives = 253/504 (50%), Gaps = 60/504 (11%)

Query: 19  QLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRR 78
           +LA   + E +L  + E   +  R   +    Q     +  +++     ++EK   ++  
Sbjct: 197 RLAESEKSEIQLNVK-ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 255

Query: 79  SLEARREKLRQL---MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE--EQRKL 133
            +  + E+LR+    M+E+++ + R+ + LR     QE+ +REQ  +L+  K+  EQ + 
Sbjct: 256 KMWRQEERLREQEGKMREQEEKMRRQEKRLRE----QEKELREQEKELREQKKLREQEEQ 311

Query: 134 IAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYER 193
           + EQ   E   +   K+RE E  + ++     WE +K+ ++Q++   +QE + +E + ER
Sbjct: 312 MQEQ--EEKMWEQEEKMREQEEKMWRQEE-RLWEQEKQMREQEQKMRDQEERMWEQD-ER 367

Query: 194 ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEAT------KLKKEQENLLKQ 247
            R E  ERM+ +E+  + E+K+Q E  +++ E+ K++E E T      K++K++EN+ +Q
Sbjct: 368 LR-EKEERMREQEKMWEQEEKMQEEERIREREK-KMREEEETMREQEEKMQKQEENMWEQ 425

Query: 248 R----------------WELERLEEERK----QMEAFRQKAEL-GRFLRHQYNAQLSRRT 286
                            WE E+++E+ +    Q E  R + E+ G+  +     ++  + 
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 485

Query: 287 QQIQEELEADRRILQALLEKEDE--SQRLHLARREQVMADVAWMKQAIEEQLQLERAREA 344
            Q+ E+ E  R   Q + ++E+    Q   L  +E+ M +   M Q  E+  + ++ +E 
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545

Query: 345 ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
           E +   +EE     + RE E  RER  + R   E++  +++++QE+ E+  R QEE +  
Sbjct: 546 EKKTWDQEE-----KMREEERMREREKKMREEEEMMREQEEKMQEQ-EEKMREQEEKMWE 599

Query: 405 REQLIRNLEEV---RELARREKEESEKLKSARKQ--ELEAQVAERRLQAWEADQQEEEEE 459
           +E+ ++  EE    +E    E+EE +K++   +   E E ++ E+  + WE +++  E+E
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659

Query: 460 EEARRVEQLSDALLQQEAETMAEQ 483
           E+ R  E+     +Q + E M EQ
Sbjct: 660 EKMREQEE----KMQGQEEKMREQ 679



 Score =  132 bits (332), Expect = 7e-31
 Identities = 119/501 (23%), Positives = 248/501 (49%), Gaps = 46/501 (9%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++RL +Q  + REQE ++R+Q E+  R          K+     K   Q      Q 
Sbjct: 258 WRQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQEKELREQKKLREQEEQMQEQE 316

Query: 70  EKMKEEKRRSLEARREKLRQ---LMQEEQDLLARE--LEELRLSMNLQERRIREQHGKLK 124
           EKM E++ +  E   +  RQ   L ++E+ +  +E  + +    M  Q+ R+RE+  +++
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376

Query: 125 SAK---EEQRKLIAEQLLYEHWKKNNPK---LREMELDLHQKHVVNSWEMQKEEKKQQEA 178
             +   E++ K+  E+ + E  KK   +   +RE E  + QK   N WE Q+E++ QQ+ 
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKM-QKQEENMWE-QEEKEWQQQR 434

Query: 179 TAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
             EQ+ K +E E  + + E +   + EE+ R  E+    E  + + E+++ +E +  + +
Sbjct: 435 LPEQKEKLWEQEKMQEQEEKI--WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492

Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
           ++  +  ++ W+ E  E   +Q E  R+K E     R +   ++ ++ ++++EE +   +
Sbjct: 493 EKMRDQEQKMWDQE--ERMWEQDERLREKEE-----RMREQKKMWQQEEKMREEKKTQEQ 545

Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQL--ERAREAELQML-----LR 351
             +   ++E   +   +  RE+ M +   M +  EE++Q   E+ RE E +M      ++
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ 605

Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIE------QNRRAQEESLKHR 405
           E+ ++MWE+ E  W +E   + +   E++  +++++QE+ E      +  R QEE ++ +
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665

Query: 406 EQLIRNLEE-VRELARREKEESEKLKSA----RKQELEAQVAERRL-----QAWEADQQE 455
           E+ ++  EE +RE   + + + EK++      R QE +    E ++     + W  ++  
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725

Query: 456 EEEEEEARRVEQLSDALLQQE 476
           E+EE    + E++ + L + E
Sbjct: 726 EKEERIRDQKEKMQERLPEHE 746



 Score =  129 bits (325), Expect = 5e-30
 Identities = 127/474 (26%), Positives = 231/474 (48%), Gaps = 52/474 (10%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEE-QDLLARELEELRLS 108
           K AE   K     S  +  +  +KE KR+ LE  +  L Q+     Q+ + R+ EELR  
Sbjct: 188 KNAELQEKLRLAESEKSEIQLNVKELKRK-LERAKFLLPQVQTNTLQEEMWRQEEELREQ 246

Query: 109 ----------MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
                     M  QE R+REQ GK++  +E+ R+   E+ L E  K+    LRE E +L 
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR--QEKRLREQEKE----LREQEKELR 300

Query: 159 QKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERM-KAEEERRQLEDKL-- 215
           ++  +   E Q +E  Q+E   EQE K  E E +  R+E  ER+ + E++ R+ E K+  
Sbjct: 301 EQKKLREQEEQMQE--QEEKMWEQEEKMREQEEKMWRQE--ERLWEQEKQMREQEQKMRD 356

Query: 216 QAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLR 275
           Q E + +Q E L+ KE    +  +EQE + +Q  +++  E  R++ +  R++ E  R   
Sbjct: 357 QEERMWEQDERLREKE----ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE 412

Query: 276 HQYNAQLSRRTQQIQEELEADRRILQA--LLEKED-ESQRLHLARREQVMADVAWMKQAI 332
            +   Q     +Q ++E +  R   Q   L E+E  + Q   +  +E+ + D   M    
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 472

Query: 333 EEQLQLERAREAELQML-----LREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQI 387
           ++  + E+ RE E QM      +R++ ++MW++ E  W ++   R++        +  Q 
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532

Query: 388 QEKIEQNRRAQEESLK--HREQLIRNLEEVRELARREKEESEKLKSARK--QELEAQVAE 443
           +EK+ + ++ QE+  K   +E+ +R  E +RE  ++ +EE E ++   +  QE E ++ E
Sbjct: 533 EEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMRE 592

Query: 444 RRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAW 497
           +  + WE +++ +E+EE+           + ++ E M EQ    K     ++ W
Sbjct: 593 QEEKMWEQEEKMQEQEEK-----------MWEQEEKMWEQEEEDKMQEQEEMMW 635



 Score =  127 bits (319), Expect = 2e-29
 Identities = 121/469 (25%), Positives = 232/469 (49%), Gaps = 69/469 (14%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
           W  ++RL +Q  + REQE ++R Q    WEQ+ R     +    ++  W  +   Q    
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393

Query: 66  AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKL-- 123
             +REK   E+  ++  + EK+++   +E+++  +E +E       Q++R+ EQ  KL  
Sbjct: 394 IREREKKMREEEETMREQEEKMQK---QEENMWEQEEKEW------QQQRLPEQKEKLWE 444

Query: 124 KSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--QQEATAE 181
           +   +EQ + I EQ           K+R+ E            EM  +EKK  +QE   E
Sbjct: 445 QEKMQEQEEKIWEQ---------EEKIRDQE------------EMWGQEKKMWRQEKMRE 483

Query: 182 QENKRYENEYERARREAL-----ERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEAT 235
           QE++ +E E +   +E       ERM  ++ER R+ E++++ +  + Q EE K++E + T
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE-KMREEKKT 542

Query: 236 KLKKEQENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
           +   EQE   K+ W+ E ++ EE +  E  ++  E    +R Q         +++QE+ E
Sbjct: 543 Q---EQE---KKTWDQEEKMREEERMREREKKMREEEEMMREQ--------EEKMQEQEE 588

Query: 295 ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEA 354
             R   + + E+E++ Q       EQ   +  W +Q  E+++Q +     E +  ++E+ 
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQ--EEKMW-EQEEEDKMQEQEEMMWEQEEKMQEQE 645

Query: 355 KEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE 414
           ++MWE+ E    RE+  + R   E + G++++++E+ E+  + QEE ++ +E+ +R  EE
Sbjct: 646 EKMWEQEEK--MREQEEKMREQEEKMQGQEEKMREQ-EEKMQGQEEKMREQEEKMRGQEE 702

Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEAR 463
            +   + EK   ++ K   ++E+  +  E R++  +   QE   E E R
Sbjct: 703 -KMWGQEEKMWGQEEKMWGQEEMREK--EERIRDQKEKMQERLPEHEER 748



 Score =  102 bits (253), Expect = 1e-21
 Identities = 117/483 (24%), Positives = 220/483 (45%), Gaps = 66/483 (13%)

Query: 19  QLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRR 78
           Q A ++ ++  L +  +   R           Q   S+ +++ +    Y  E  KE    
Sbjct: 112 QDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDAL 171

Query: 79  SLEARR-----EKLRQLMQEEQDLLA-RELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
           SLE  R     E+L++   E Q+ L   E E+  + +N++E +      KL+ AK    +
Sbjct: 172 SLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK-----RKLERAKFLLPQ 226

Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
           +    L  E W++   +LRE E  + +K     W  ++  ++Q+    EQE K    E +
Sbjct: 227 VQTNTLQEEMWRQEE-ELREQEKKI-RKQEEKMWRQEERLREQEGKMREQEEKMRRQE-K 283

Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELE 252
           R R +  E  + E+E R+ +   + E  +Q+ EE   ++ E  K+++++E + +Q    E
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE--KMREQEEKMWRQE---E 338

Query: 253 RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
           RL E+ KQM    QK                    Q +   E D R    L EKE+    
Sbjct: 339 RLWEQEKQMREQEQKMR-----------------DQEERMWEQDER----LREKEERM-- 375

Query: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
                REQ   +  W ++  E+  + ER RE E +M  REE + M E+ E    +E +  
Sbjct: 376 -----REQ---EKMWEQE--EKMQEEERIREREKKM--REEEETMREQEEKMQKQEENMW 423

Query: 373 DRLMSEVLTGRQQQIQEKI--EQNRRAQEESLKHREQLIRNLEEV--------RELARRE 422
           ++   E    R  + +EK+  ++  + QEE +  +E+ IR+ EE+        R+   RE
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 483

Query: 423 KEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQL--SDALLQQEAETM 480
           +E+    +  + ++ E ++ ++  + WE D++  E+EE  R  +++   +  +++E +T 
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543

Query: 481 AEQ 483
            ++
Sbjct: 544 EQE 546



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 72/295 (24%), Positives = 140/295 (47%), Gaps = 27/295 (9%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++++  Q  +  +QE R+   WEQ+ R     +    ++  W  +   +      ++
Sbjct: 489 WEQEEKMRDQEQKMWDQEERM---WEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545

Query: 70  EKM---KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSA 126
           EK    +EEK R  E  RE+ +++ +EE+  + RE EE    M  QE ++REQ  K+   
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEE--MMREQEE---KMQEQEEKMREQEEKMWEQ 600

Query: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186
           +E+ ++   +      W++      + E D  Q+     WE +++ ++Q+E   EQE K 
Sbjct: 601 EEKMQEQEEKM-----WEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655

Query: 187 YENEYERARREALERMKAEEERRQ-LEDKLQAEALLQQMEELKLKEVEATKLKKEQENLL 245
            E E         E+M+ +EE+ Q  E+K++ +    Q +E K++E E  K++ ++E + 
Sbjct: 656 REQE---------EKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE-EKMRGQEEKMW 705

Query: 246 KQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
            Q  ++   EE+    E  R+K E  R  + +   +L    ++  E      ++L
Sbjct: 706 GQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVL 760



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 113/492 (22%), Positives = 217/492 (44%), Gaps = 69/492 (14%)

Query: 4   PTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSS-KTSYQR 62
           P LP +    ++  Q    + +++    +QW       R +D    K    ++ +T+   
Sbjct: 5   PHLPPHPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSE 64

Query: 63  SMHAYQREKM-----KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR 117
             H+ + EK      +E  RR +EA+   +R        +L  +  EL  ++   +   R
Sbjct: 65  GCHSPEDEKKASHQHQEALRREIEAQDHTIR--------ILTCQKTELETALYYSQDAAR 116

Query: 118 E-QHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQ 176
           + + G L  +K+   +L      +  W       R +         V++W  +K ++  +
Sbjct: 117 KFEDGNLGESKDLAGRL------HHSWHFAGELQRALS-------AVSTWH-KKADRYIE 162

Query: 177 EATAEQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEAT 235
           E T E++    E        E L++  AE +E+ +L +  ++E  L  ++ELK K   A 
Sbjct: 163 ELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLN-VKELKRKLERAK 221

Query: 236 KLKKE------QENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            L  +      QE + +Q  EL   E++ RKQ E   ++ E           +L  +  +
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-----------RLREQEGK 270

Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQM 348
           ++E+ E  RR  + L E+E E +      REQ         +  EEQ+Q +  +  E + 
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKL------REQEEQMQEQEEKMWEQEE 324

Query: 349 LLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQL 408
            +RE+ ++MW + E  W +E+  R+          Q+Q     E+    Q+E L+ +E+ 
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMRE----------QEQKMRDQEERMWEQDERLREKEER 374

Query: 409 IRNLEEVRELARREKEES---EKLKSARKQELEAQVAERRLQAWEADQQEEEEEE-EARR 464
           +R  E++ E   + +EE    E+ K  R++E   +  E ++Q  E +  E+EE+E + +R
Sbjct: 375 MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 434

Query: 465 VEQLSDALLQQE 476
           + +  + L +QE
Sbjct: 435 LPEQKEKLWEQE 446



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 79/385 (20%), Positives = 164/385 (42%), Gaps = 42/385 (10%)

Query: 123 LKSAKEEQRKLIAEQLLYEHWKK-NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
           + S K  Q KL   +  +  +++ N   +     D  +K + N      E    +   + 
Sbjct: 12  MMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNG--TNPETTTSEGCHSP 69

Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
           ++ K+  ++++ A R  +E           +      AL    +  +  E       K+ 
Sbjct: 70  EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDL 129

Query: 242 ENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
              L   W     L+     +  + +KA+       +Y  +L++    +  EL  +    
Sbjct: 130 AGRLHHSWHFAGELQRALSAVSTWHKKAD-------RYIEELTKERDALSLELYRNTITN 182

Query: 301 QALLEKEDESQ---RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
           + L +K  E Q   RL  + + ++  +V  +K+      +LERA+    Q+      +EM
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKR------KLERAKFLLPQVQTNTLQEEM 236

Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE---- 413
           W  R+ E  RE+  + R   E +  ++++++E+ E   R QEE ++ +E+ +R  E    
Sbjct: 237 W--RQEEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMRRQEKRLREQEKELR 293

Query: 414 -EVRELARREK---------EESEKL--KSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
            + +EL  ++K         E+ EK+  +  + +E E ++  +  + WE ++Q  E+E++
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 353

Query: 462 ARRVEQL---SDALLQQEAETMAEQ 483
            R  E+     D  L+++ E M EQ
Sbjct: 354 MRDQEERMWEQDERLREKEERMREQ 378


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score =  132 bits (331), Expect = 1e-30
 Identities = 129/519 (24%), Positives = 251/519 (48%), Gaps = 69/519 (13%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSS--------K 57
           W  ++RL +Q  + REQE ++R Q    WEQ+ R     +    ++  W          K
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKK 431

Query: 58  TSYQRSMHAYQREKMKEEKR-RSLEARREKLRQLMQEEQDLLARELEEL--RLSMNLQER 114
              Q      Q EKM+EE+R R  E +  +  + M+E+++ + ++ E +  +     Q++
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491

Query: 115 RIREQHGKLKSAK----------EEQRKLIAEQLLYEHWKK--NNPKLREMELDLHQKHV 162
           R+ EQ  KL   +          E++ K+  ++ ++   KK     K+RE E  + ++  
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551

Query: 163 VNSWEMQK---EEKKQQEATAEQENKRYENEY----ERARREALERMKAEEER-RQLEDK 214
               + QK   +E++ ++ T EQE K ++ E     E   RE  ++M+ EEE  R+ E+K
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 215 LQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFR---QKAELG 271
           +Q +    Q +E K+ E E  K+++++E + +Q  E +  E+E K  E  R   QK +L 
Sbjct: 612 MQEQEEKMQEQEEKMWEQEE-KMQEQEEKMWEQ--EEKMWEQEEKMWEQQRLPEQKEKLW 668

Query: 272 RFLRHQYNAQLSRRTQQIQEELEADRRILQALLE-------KEDESQRLHLARREQVMAD 324
              + Q   ++  + ++I E+ + +++  +   +       +E+ES R     RE+ M +
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR----EREKKMRE 724

Query: 325 VAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ 384
              M +  EE++Q +  +  E +  + E+ ++MWE+ E  W ++R    +   ++    +
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEK 782

Query: 385 QQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAER 444
            Q QEKI +    QEE ++ +E+ +R  EE      + + + EK+   R QE +    E 
Sbjct: 783 MQEQEKIWE----QEEKMRDQEEKMRGQEE------KMRGQEEKM---RGQEEKMWGQEE 829

Query: 445 RLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
           ++  W  +++   +EE+    E+  +  +Q + E M EQ
Sbjct: 830 KM--WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866



 Score =  130 bits (328), Expect = 2e-30
 Identities = 125/511 (24%), Positives = 243/511 (47%), Gaps = 72/511 (14%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTS--------YQ 61
           W  ++RL +Q    REQE  LR+Q E   +  +M +    ++  W  +          ++
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQE---QEEKMWEQEEKMREQEEKMWR 373

Query: 62  RSMHAYQREKM---KEEKRRSLEARR----EKLRQLMQ--EEQDLLARELEELRLSMNLQ 112
           +    +++EK    +E+K R  E R     E+LR+  +   EQ+ +  ++E++R     +
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR-----E 428

Query: 113 ERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKK---NNPKLREMELDLHQKHVVNSWEM- 168
           E++++EQ    K  ++++ K+  E+ + E  KK       +RE E +  QK   N WE  
Sbjct: 429 EKKMQEQE---KKTRDQEEKMQEEERIREREKKMREEEETMREQE-EKMQKQEENMWEQE 484

Query: 169 -----------QKEEKKQQEATAEQENKRYENEYERARREAL----ERMKAEEERRQLED 213
                      QKE+  +QE   EQE K +E E +   +E +    ++M  +E+ R+ ED
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544

Query: 214 KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF 273
           ++  +    + +E K+ + E    KK QE   K   + E++ EE +  E  ++  E    
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 604

Query: 274 LRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAW-MKQAI 332
           +R Q         +++QE+ E  +   + + E+E++ Q       EQ   +  W  ++ +
Sbjct: 605 MREQ--------EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ--EEKMWEQEEKM 654

Query: 333 EEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIE 392
            EQ +L   +E   +    +E ++M E+ E  W +E+  +           Q+Q ++  +
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK---------TQEQEKKTWD 705

Query: 393 QNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD 452
           Q +  +EES++ RE+ +R  EE+     RE+EE  + +  + QE E ++ E+  + WE +
Sbjct: 706 QEKMREEESMREREKKMREEEEM----MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQE 761

Query: 453 QQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
           ++  E++    + E+L +    QE E + EQ
Sbjct: 762 EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792



 Score =  120 bits (301), Expect = 3e-27
 Identities = 101/444 (22%), Positives = 221/444 (49%), Gaps = 52/444 (11%)

Query: 13  QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAY- 67
           ++++ ++    REQE ++++Q    WEQ  + ++   +   K+  W  +   ++    + 
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515

Query: 68  QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAK 127
           Q EK+++++    + ++   ++ M+E++D +  + E++R     QE+++ +Q  +++   
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD----QEQKMWDQEERMEKKT 571

Query: 128 EEQRKLIAEQ----LLYEHWKKNNPKLREME---LDLHQKHVVNSWEMQKEEKK---QQE 177
           +EQ K   +Q       E  ++   K+RE E    +  +K      +MQ++E+K   Q+E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631

Query: 178 ATAEQENKRYENEYERARRE----ALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
              EQE K +E E +   +E      +R+  ++E+    +K+Q +  +Q+ EE   K  E
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEE---KIWE 688

Query: 234 ATKLKKEQENLLKQRWELERLEEE---RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ 290
             K++K+ +   K+ W+ E++ EE   R++ +  R++ E+ R    +   Q  +  +Q +
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748

Query: 291 EELEADRRI----------------LQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
           E  E + ++                 + L E E   ++  +  +E+ M D     +  EE
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808

Query: 335 QL--QLERAREAELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEK 390
           ++  Q E+ R  E +M  +EE  +MW + E  W +E     ++  M E + G++++++E+
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEE--KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866

Query: 391 IEQNRRAQEESLKHREQLIRNLEE 414
            E+  R QEE ++ +E+ +R  EE
Sbjct: 867 -EEKMRGQEEKMREQEEKMRGQEE 889



 Score =  110 bits (276), Expect = 2e-24
 Identities = 127/485 (26%), Positives = 221/485 (45%), Gaps = 79/485 (16%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEE-QDLLARELEELRLS 108
           K AE   K     S  +  +  +KE KR+ LE  +  L Q+     Q+ + R+ EELR  
Sbjct: 226 KNAELQEKLPLAESEKSEIQLNVKELKRK-LERAKFLLPQVQTNTLQEEMWRQEEELREQ 284

Query: 109 ----------MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH 158
                     M  QE R+REQ GK++  +E+             W++   +LRE E +L 
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKM------------WRQEK-RLREQEKELR 331

Query: 159 QKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEER--------RQ 210
           ++        QKE ++Q+E   EQE K +E E +   RE  E+M  +EER        R+
Sbjct: 332 EQE--KELREQKELREQEEQMQEQEEKMWEQEEKM--REQEEKMWRQEERLWEQEKQMRE 387

Query: 211 LEDKL--QAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKA 268
            E K+  Q E + +Q E L+ KE    + +K  E + K R E +  E+E+K  +   +  
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447

Query: 269 ELGRFLRHQYNAQLSRRTQQIQEE-LEADRRILQALLEKEDESQRLHLARRE-------Q 320
           E  R    +   +    T + QEE ++     +    EKE + QRL   + +       Q
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507

Query: 321 VMADVAW-MKQAIEEQLQL----------ERAREAELQML-----LREEAKEMW------ 358
              +  W  ++ I +Q ++          E+ RE E QM      +R++ ++MW      
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567

Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
           EK+  E  ++   ++  M E    R ++ ++K+    R +EE ++ +E+ ++  EE    
Sbjct: 568 EKKTQEQEKKTWDQEEKMRE--EERMREREKKM----REEEEMMREQEEKMQEQEE---- 617

Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
             +E+EE    +  + QE E ++ E+  + WE +++  E++    + E+L +    QE E
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677

Query: 479 TMAEQ 483
            M EQ
Sbjct: 678 KMQEQ 682



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 99/456 (21%), Positives = 206/456 (45%), Gaps = 65/456 (14%)

Query: 51  QAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARR--------EKLRQLMQEEQDLLAREL 102
           Q   S+ ++  +    Y  E  KE    SLE  R        +K    +QE+  L   E 
Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEK 241

Query: 103 EELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHV 162
            E++L+       ++E   KL+ AK    ++    L  E W++   +LRE E  + +K  
Sbjct: 242 SEIQLN-------VKELKRKLERAKFLLPQVQTNTLQEEMWRQEE-ELREQEKKI-RKQE 292

Query: 163 VNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQ 222
              W  ++  ++Q+    EQE K +  E +R R +  E  + E+E R+ ++  + E  +Q
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQE-KRLREQEKELREQEKELREQKELREQEEQMQ 351

Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
           + EE   ++ E  K+++++E + +Q    ERL E+ KQM    QK         + + +L
Sbjct: 352 EQEEKMWEQEE--KMREQEEKMWRQE---ERLWEQEKQMREQEQKMRDQEERMWEQDERL 406

Query: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
             + ++++E+ +   ++ +   EK+ + Q      +E+ M +   +++  E++++ E   
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER-EKKMREEEET 465

Query: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
             E +  ++++ + MWE+ E EW ++R          L  +++++ E  ++  + QEE +
Sbjct: 466 MREQEEKMQKQEENMWEQEEKEWQQQR----------LPEQKEKLWE--QEKMQEQEEKI 513

Query: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
             +E+ IR+ EE   +  +EK+                        W  ++  E+E++  
Sbjct: 514 WEQEEKIRDQEE---MWGQEKK-----------------------MWRQEKMREQEDQMW 547

Query: 463 RRVEQLSDALLQQEAETMAEQGYRPKPYGHPKIAWN 498
            + E++ D   Q++     E+    K     K  W+
Sbjct: 548 EQEEKMRD---QEQKMWDQEERMEKKTQEQEKKTWD 580



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 60/271 (22%), Positives = 131/271 (48%), Gaps = 20/271 (7%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++++ +Q  +  EQE ++   WEQ  + +    +   K+  W  +   ++     Q 
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKM---WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQE 683

Query: 70  EKMKEEKRRSLEARREKLR----QLMQEEQDLLARE--LEELRLSMNLQERRIREQHGKL 123
           EK+ E+++   + + ++ +    + M+EE+ +  RE  + E    M  QE +++EQ  K+
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743

Query: 124 KSAKEEQRKLIAEQLLYEH----WKKNNPKLREMELDLHQKHVVNS--WEMQKEEKKQQE 177
           +  +EE  +   E+ ++E     W++     ++ +L  H+K       WE +++ + Q+E
Sbjct: 744 QEQEEEMWE--QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE 801

Query: 178 ATAEQENKRYENEYERARREALERMKAEEERRQ-LEDKLQAEALLQQMEELKLKEVEATK 236
               QE K    E +   +E  E+M  +EE+    E+K+  +      +E K++E    +
Sbjct: 802 KMRGQEEKMRGQEEKMRGQE--EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859

Query: 237 LKKEQENLLKQRWELERLEEERKQMEAFRQK 267
            +K +E   K R + E++ E+ ++M    +K
Sbjct: 860 EEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  130 bits (328), Expect = 2e-30
 Identities = 117/485 (24%), Positives = 240/485 (49%), Gaps = 44/485 (9%)

Query: 28  ARLRQQWEQNSRYFRMSDICSSKQ-------AEWSSKTSYQRSMHAYQREKMKE--EKRR 78
           A+L+ Q E+N  + R++     K         EW  K   Q      Q EK++E  EK R
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 338

Query: 79  SLEA----RREKLR---QLMQEEQDLLARELE---ELRLSMNLQERRIREQHGKLKSAKE 128
             E     + EK+R   ++M E+++ + R+ E   E    M  QE  + E+  K++  +E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 398

Query: 129 E--QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186
           +  +++ I EQ   E  ++   K+RE E    Q+     W  +++ ++Q+E   EQE K 
Sbjct: 399 KMHEQEKIREQ---EEKRQEEEKIREQEK--RQEQEAKMWRQEEKIREQEEKIREQEKKM 453

Query: 187 YENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL-KLKEVEATKLKKEQENLL 245
           +  E E+   +  E+++ EE+R++ E+  + E  + + EE+ + KE    K+ +++E + 
Sbjct: 454 WRQE-EKIHEQ--EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE----KMHEQEEKIR 506

Query: 246 KQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
           KQ  ++ R EE+ R+Q E  R++ E  +  R +   +      + +E++    +I +   
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEE--KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564

Query: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAE 364
            +E E +      + +   +  W ++    + + +R  + E      E+ +E  EK + +
Sbjct: 565 RQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624

Query: 365 WARERSARDRLMS-EVLTGRQQQIQEKIEQNRRAQEESLKHREQLI-RNLEEVRELARRE 422
             + R   +++   E +T  Q++   + E+    QEE ++ +E+ + R  E++RE  ++ 
Sbjct: 625 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684

Query: 423 KEESEKLKSARK--QELEAQVAERRLQAWEADQQEEEEEEEARRVEQL---SDALLQQEA 477
           +E+ EK++   +  QE E ++ E+  +  E +++ +E+EE+ RR E+     +  L+Q+ 
Sbjct: 685 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744

Query: 478 ETMAE 482
           E M E
Sbjct: 745 EKMQE 749



 Score =  118 bits (295), Expect = 1e-26
 Identities = 111/429 (25%), Positives = 222/429 (51%), Gaps = 52/429 (12%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAEWSSKTSYQRSMH 65
           W  ++++ +Q     E+E ++R+Q    WE+  +  R  ++   K+ +       +  MH
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE---LEEKMH 401

Query: 66  AYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKS 125
             ++ + +EEKR+  E  RE+ ++  QE++  + R+ E++R     QE +IREQ  K+  
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIRE----QEEKIREQEKKMWR 455

Query: 126 AKE---EQRKLIAEQLLYEH---WKKNNPKLREMELDLHQKHVVNSWE--MQKEEKK--- 174
            +E   EQ K+  E+   E    W++   K+ E E    QK  ++  E  ++K+E+K   
Sbjct: 456 QEEKIHEQEKIREEEKRQEQEEMWRQEE-KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514

Query: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEA 234
           Q+E   EQE K  E E +  R+E  E+++ +EE  + E+K+  +  + + E+   ++ + 
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQE--EKIREQEEMWREEEKMHEQEKIWEEEK---RQEQE 569

Query: 235 TKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
            K+ +++E + +Q  ++ R EE+ ++ E  RQ+ E   + + +   ++  + ++IQE+ E
Sbjct: 570 DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE---KIREQEEKIQEQEE 626

Query: 295 ADRRILQALLEKED--ESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQM-- 348
             R   + + E+E+  + Q   +  +E+ M +     Q  EE +  Q E+ RE E ++  
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686

Query: 349 ---LLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHR 405
               +RE+ + M E+ E  W +E         E +  +++++QE+ E+ RR QEE +  +
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQE---------EKMCEQEEKMQEQEEKMRR-QEEKMWEQ 736

Query: 406 EQLIRNLEE 414
           E  +R  EE
Sbjct: 737 EVRLRQQEE 745



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 126/498 (25%), Positives = 238/498 (47%), Gaps = 74/498 (14%)

Query: 17  NQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEK 76
           ++Q A  + QEA LR++ E      R   I + ++ E      Y  S HA ++  ++ E 
Sbjct: 109 DEQKASHQHQEA-LRRELEAQVHTIR---ILTCQKTELQMALYY--SQHAVKQ--LEGEA 160

Query: 77  RRSLEARREKLRQLMQEEQDLLA---------RELEELR-----LSMNLQERRIREQHGK 122
           R  +    +  +   + EQ L A         R +EEL      LS+ L    I ++  K
Sbjct: 161 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220

Query: 123 LKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
            K+AK +++  + E    E   + K+   KL   +L L Q+ +    E     K+ Q  +
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--QAEADHLGKELQSVS 278

Query: 180 AEQENKRYENE-YERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKL 237
           A+ + +  ENE + R  ++  E+M  +EE+ ++ E+K+Q +    + +E K++E E  K+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE-KM 337

Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
           ++++E +    WE E  E+ R+Q E   +K E           ++ R+ + + E+ E  R
Sbjct: 338 RRQEEMM----WEKE--EKMRRQEEMMWEKEE-----------KMRRQEEMMWEKEEKMR 380

Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
           R  + + EKE++ + L     E+ M +   +++  E++ + E+ RE E +   +E+  +M
Sbjct: 381 RQEEMMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKM 432

Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQI--QEKI-EQNRRAQEESLKHREQLIRNLEE 414
           W  R+ E  RE+  + R   + +  ++++I  QEKI E+ +R ++E +  +E+ I   EE
Sbjct: 433 W--RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE 490

Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
           +     +  E+ EK+   RKQE +          W   Q+E+  E+E +  EQ      Q
Sbjct: 491 IWRQKEKMHEQEEKI---RKQEEKV---------WR--QEEKIREQEEKIREQEEKMWRQ 536

Query: 475 QEAETMAEQGYRPKPYGH 492
           +E     E+ +R +   H
Sbjct: 537 EEKIREQEEMWREEEKMH 554



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 83/340 (24%), Positives = 169/340 (49%), Gaps = 36/340 (10%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQ--NSRYFRMSDICSSKQAEWSSKTSYQRSMHAY 67
           W  ++++ +Q  + REQE ++ +Q E+       R  +    ++  W  +         +
Sbjct: 433 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW 492

Query: 68  -QREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
            Q+EKM  +EEK R  E +  +  + ++E+++ + RE EE    M  QE +IREQ    +
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI-REQEE---KMWRQEEKIREQEEMWR 548

Query: 125 SAKE--EQRKLIAEQLLYEH----WKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA 178
             ++  EQ K+  E+   E     W++   K+RE E  +        W  +++ ++Q+E 
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEE-KIREQEEKV--------WRQEEKIREQEEK 599

Query: 179 TAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
             EQE K ++ E E+ R +  +  + EE+ R+ E+K++ +  + Q +E K+ E E  K+ 
Sbjct: 600 RQEQEEKMWKQE-EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE-EKMC 657

Query: 239 KEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
           +++E + +Q   + R EE+ R+Q +  R++ E  R        Q  +  +Q ++  E + 
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 717

Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
           +     +++++E  R    R+E+ M +     +  EE++Q
Sbjct: 718 K-----MQEQEEKMR----RQEEKMWEQEVRLRQQEEKMQ 748



 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 67/276 (24%), Positives = 134/276 (48%), Gaps = 25/276 (9%)

Query: 13  QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEWSSKTSYQRSMHAY 67
           Q+ + +Q  +  EQE ++R+Q    W Q  +     + I   ++  W  +   +     +
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547

Query: 68  QREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL---QERRIREQHGKLK 124
           + E+   E+ +  E  +       QE++D + R+ E++R        QE +IREQ  K +
Sbjct: 548 REEEKMHEQEKIWEEEKR------QEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601

Query: 125 SAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
             +E+   Q + I EQ   E  ++   K+RE E  + ++  +   E +++  +Q+E   E
Sbjct: 602 EQEEKMWKQEEKIREQ--EEKIQEQEEKIREQEEKIREQEEMTQ-EQEEKMGEQEEKMCE 658

Query: 182 QENKRYENEYERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKLKKE 240
           QE K  E E    R+E  E+++ +E++ R+ E+K++ +  + Q +E K+ E E      E
Sbjct: 659 QEEKMQEQEETMWRQE--EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC--E 714

Query: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRH 276
           QE  ++++ E  R +EE+   +  R + +  +   H
Sbjct: 715 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 76/374 (20%), Positives = 170/374 (45%), Gaps = 47/374 (12%)

Query: 123 LKSAKEEQRKLI-AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
           + S +  Q KL  A++ L +H  + NP +     D  +K + N    +        +  +
Sbjct: 50  MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPED 109

Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
           ++   ++++      EAL        RR+LE          Q+  +++   + T+L   Q
Sbjct: 110 EQKASHQHQ------EAL--------RRELE---------AQVHTIRILTCQKTEL---Q 143

Query: 242 ENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQ 301
             L   +  +++LE E + +    +  +  +F      A  +  TQ+     +ADR I +
Sbjct: 144 MALYYSQHAVKQLEGEARDL--ISRLHDSWKFAGELEQALSAVATQK----KKADRYIEE 197

Query: 302 ALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKR 361
             L KE ++  L L R      ++      ++E+LQL  + ++E+Q+ ++E  +++   +
Sbjct: 198 --LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK 255

Query: 362 EAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARR 421
                ++  A    + + L     ++Q ++E+N      + +  E++ R  E+++E   +
Sbjct: 256 LLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 315

Query: 422 EKEESEKLKSARK--QELEAQVAERRLQAWEADQ----QEE---EEEEEARRVEQL---S 469
            +E+ EK++   +  +E E ++  +    WE ++    QEE   E+EE+ RR E++    
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375

Query: 470 DALLQQEAETMAEQ 483
           +  ++++ E M E+
Sbjct: 376 EEKMRRQEEMMWEK 389


>gi|94721321 coiled-coil domain containing 11 [Homo sapiens]
          Length = 514

 Score =  129 bits (325), Expect = 5e-30
 Identities = 99/420 (23%), Positives = 213/420 (50%), Gaps = 15/420 (3%)

Query: 51  QAEWSSKTSYQRSMHAYQREKMKEEKRR---SLEARREKLRQLMQEEQDLLARELEELRL 107
           +AEW       + + +  R ++K+  +    ++E RR KLR+L+  E++    E++  + 
Sbjct: 63  KAEWDQHNDC-KILDSLVRARIKDAVQGFIINIEERRNKLRELLALEENEYFTEMQLKKE 121

Query: 108 SMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
           ++  ++ R+RE+   LK   E++R+    + L + +++   +LR   L +HQK V    +
Sbjct: 122 TIEEKKDRMREKTKLLKEKNEKERQDFVAEKLDQQFRERCEELRVELLSIHQKKVCEERK 181

Query: 168 MQ---KEEKKQQEATAEQE-NKRYENEYERARREALERMKAEEERRQLEDKLQAE-ALLQ 222
            Q    EE  +Q+   EQ  +K +E +     R A E+ +A+E RRQ E        L  
Sbjct: 182 AQIAFNEELSRQKLVEEQMFSKLWEED-----RLAKEKREAQEARRQKELMENTRLGLNA 236

Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
           Q+  +K +      LK+E+  L++      + E E+  ++  + K E    L+     ++
Sbjct: 237 QITSIKAQRQATQLLKEEEARLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERI 296

Query: 283 SRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAR 342
               Q+ ++E + + +++Q  L+   E       +RE ++ +     + + ++ + E+A+
Sbjct: 297 EHIQQEYRDEQDLNMKLVQRALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQ 356

Query: 343 EAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL 402
           E E   +L E+  +   +++ E   E+ AR +L+ EV+  R+ Q+QEK+++  + QEE  
Sbjct: 357 EKEFDRILEEDKAKKLAEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERA 416

Query: 403 KHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
             ++ +  +L+E+    +      ++L    +++L+ Q+A ++ Q+ EA+++E+  E EA
Sbjct: 417 MEQKHINESLKELNCEEKENFARRQRLAQEYRKQLQMQIAYQQ-QSQEAEKEEKRREFEA 475



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 98/420 (23%), Positives = 206/420 (49%), Gaps = 40/420 (9%)

Query: 74  EEKRRSLEARREKLRQLMQEEQDLLARELEE---LRLSMNLQERRIREQHGKLKSAKEEQ 130
           E  RRS +     L  +   E+D L  E ++    ++  +L   RI++         EE+
Sbjct: 38  ERIRRSHQKHNAILASIKSSERDRLKAEWDQHNDCKILDSLVRARIKDAVQGFIINIEER 97

Query: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
           R  + E L  E     N    EM+L   +K  +   E +K+  +++    +++N++   +
Sbjct: 98  RNKLRELLALEE----NEYFTEMQL---KKETI---EEKKDRMREKTKLLKEKNEKERQD 147

Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
           +   + +   R + EE R +L    Q +   ++  ++   E E ++ K  +E +  + WE
Sbjct: 148 FVAEKLDQQFRERCEELRVELLSIHQKKVCEERKAQIAFNE-ELSRQKLVEEQMFSKLWE 206

Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLS-----RRTQQIQEELEADRRILQ---A 302
            +RL +E+++ +  R++ EL    R   NAQ++     R+  Q+ +E EA  R+++   A
Sbjct: 207 EDRLAKEKREAQEARRQKELMENTRLGLNAQITSIKAQRQATQLLKEEEA--RLVESNNA 264

Query: 303 LLEKEDESQRLHLARREQVMADVAWMKQAIEEQL---QLERAREAELQMLLREEAKEMWE 359
            ++ E+E   L   + +Q    +  +++A++E++   Q E   E +L M L + A +  +
Sbjct: 265 QIKHENEQDMLKKQKAKQETRTI--LQKALQERIEHIQQEYRDEQDLNMKLVQRALQDLQ 322

Query: 360 KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELA 419
           +   E  +++  R+ ++      R+Q+I  K    RR +E++ +     I   ++ ++LA
Sbjct: 323 E---EADKKKQKREDMI------REQKIYHKYLAQRREEEKAQEKEFDRILEEDKAKKLA 373

Query: 420 RREKEESEKLKSARKQELEAQVAERRLQAWEADQQE-EEEEEEARRVEQLSDALLQQEAE 478
            ++KE   + K AR+Q ++  +  R+LQ  E  Q+E +E+EE A   + ++++L +   E
Sbjct: 374 EKDKELRLE-KEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 88/387 (22%), Positives = 173/387 (44%), Gaps = 33/387 (8%)

Query: 14  QRLNQQLARQREQEARLRQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
           ++L+QQ  R+R +E R+        +    R + I  +++         Q     ++ ++
Sbjct: 151 EKLDQQF-RERCEELRVELLSIHQKKVCEERKAQIAFNEELSRQKLVEEQMFSKLWEEDR 209

Query: 72  MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
           + +EKR + EARR+K  +LM           E  RL +N Q   I+ Q    +  KEE+ 
Sbjct: 210 LAKEKREAQEARRQK--ELM-----------ENTRLGLNAQITSIKAQRQATQLLKEEEA 256

Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQE-NKRYENE 190
           +L+         +     L++ +     + ++     ++ E  QQE   EQ+ N +    
Sbjct: 257 RLVESNNAQIKHENEQDMLKKQKAKQETRTILQKALQERIEHIQQEYRDEQDLNMKLVQR 316

Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
             +  +E  ++ K + E    E K+  + L Q+ EE K +E E  ++ +E     K +  
Sbjct: 317 ALQDLQEEADKKKQKREDMIREQKIYHKYLAQRREEEKAQEKEFDRILEED----KAKKL 372

Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
            E+ +E R + EA RQ  +     R     +  +R  + QEE   +++ +   L++ +  
Sbjct: 373 AEKDKELRLEKEARRQLVDEVMCTRKLQVQEKLQREAKEQEERAMEQKHINESLKELNCE 432

Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
           ++ + ARR++       + Q   +QLQ++ A + + Q   +EE +  +   EA  A  + 
Sbjct: 433 EKENFARRQR-------LAQEYRKQLQMQIAYQQQSQEAEKEEKRREF---EAGVAANKM 482

Query: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRA 397
             D+ + EVL+   Q + + I   R+A
Sbjct: 483 CLDK-VQEVLS-THQVLPQNIHPMRKA 507


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1671 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1850 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1957

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2018 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2077 DQLRGEAE 2084



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1342 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1461 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1514 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1560

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1561 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1616

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1734

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1735 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 477  AETMAE 482
            A    E
Sbjct: 1793 AGRFRE 1798



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2156

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2572

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1959

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1960 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2134

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2192

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2370

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1422

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1423 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1517

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1518 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1622 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1667

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1725



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2481

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2600

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2655

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTV 2679



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1283

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1284 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1341 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1445 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1562 QVQVALETAQRSAE 1575



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1015 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1187

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1305

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1419

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1478

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1479 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2452 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2505 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1675 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1733

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1854 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1961

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2022 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2081 DQLRGEAE 2088



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1346 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1465 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1518 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1564

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1565 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1620

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1738

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1739 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796

Query: 477  AETMAE 482
            A    E
Sbjct: 1797 AGRFRE 1802



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2160

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2576

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1963

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1964 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2138

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2196

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2374

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1368

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1426

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1427 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1521

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1522 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1565

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1625

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1626 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1671

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1729



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2485

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2604

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2659

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2660 QRLQEAGILSAEELQRLAQGHTTV 2683



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1173 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1232

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1233 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1287

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1288 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1345 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1449 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1565

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1566 QVQVALETAQRSAE 1579



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1019 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1077

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1137

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1138 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1191

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1309

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1310 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1369

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1370 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1423

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1482

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1483 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2456 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2508

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2509 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2726


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1671 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1729

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1850 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1957

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2018 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2077 DQLRGEAE 2084



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1342 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1461 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1514 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1560

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1561 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1616

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1734

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1735 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 477  AETMAE 482
            A    E
Sbjct: 1793 AGRFRE 1798



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2156

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2572

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2573 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1959

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1960 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2134

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2192

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2370

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1364

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1422

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1423 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1517

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1518 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1621

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1622 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1667

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1725



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2481

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2600

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2655

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2656 QRLQEAGILSAEELQRLAQGHTTV 2679



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1169 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1229 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1283

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1284 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1341 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1445 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1561

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1562 QVQVALETAQRSAE 1575



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1015 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1073

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1133

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1134 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1187

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1305

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1306 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1365

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1366 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1419

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1478

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1479 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2452 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2504

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2505 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2722


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1639 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1697

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1818 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1925

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 1986 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2045 DQLRGEAE 2052



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1310 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1429 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1482 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1528

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1529 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1584

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1702

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1703 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760

Query: 477  AETMAE 482
            A    E
Sbjct: 1761 AGRFRE 1766



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2124

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2540

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2541 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1927

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1928 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2102

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2160

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2338

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1332

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1390

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1391 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1485

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1486 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1529

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1589

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1590 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1635

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1693



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2449

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2568

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2569 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2623

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2624 QRLQEAGILSAEELQRLAQGHTTV 2647



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1137 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1196

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1197 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1251

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1252 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1308

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1309 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1413 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1529

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1530 QVQVALETAQRSAE 1543



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 983  PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1041

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1101

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1102 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1155

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1273

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1274 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1333

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1334 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1387

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1446

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1447 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2420 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2472

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2473 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2690


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1808 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1866

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1987 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 2094

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2155 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2214 DQLRGEAE 2221



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1479 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1598 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1651 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1697

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1698 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1753

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1871

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1872 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929

Query: 477  AETMAE 482
            A    E
Sbjct: 1930 AGRFRE 1935



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2293

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2709

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 2096

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 2097 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2271

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2329

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2507

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1559

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1560 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1654

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1655 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1698

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1758

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1759 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1804

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1862



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2618

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2737

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2738 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2792

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2793 QRLQEAGILSAEELQRLAQGHTTV 2816



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1306 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1365

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1366 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1420

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1421 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1477

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1478 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1582 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1698

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1699 QVQVALETAQRSAE 1712



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1152 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1270

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1271 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1324

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1442

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1443 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1502

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1503 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1556

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1615

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1616 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2589 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2641

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2642 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2859


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1649 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1707

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1828 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1935

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 1996 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2055 DQLRGEAE 2062



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1320 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1439 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1492 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1538

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1539 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1594

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1712

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1713 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770

Query: 477  AETMAE 482
            A    E
Sbjct: 1771 AGRFRE 1776



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2134

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2550

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2551 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1937

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1938 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2112

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2170

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2348

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1400

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1401 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1495

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1496 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1539

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1599

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1600 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1645

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1703



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2169

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2459

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2578

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2579 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2633

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2634 QRLQEAGILSAEELQRLAQGHTTV 2657



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1147 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1206

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1207 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1261

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1262 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1318

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1319 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1423 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1539

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1540 QVQVALETAQRSAE 1553



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 993  PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1111

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1112 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1165

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1283

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1284 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1343

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1344 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1397

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1456

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1457 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2430 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2482

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2483 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1657 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1715

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1775

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1836 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1943

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2004 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2063 DQLRGEAE 2070



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1328 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1447 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1500 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1546

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1547 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1602

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1663 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1720

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1721 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778

Query: 477  AETMAE 482
            A    E
Sbjct: 1779 AGRFRE 1784



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2142

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2262

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2558

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2559 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1945

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1946 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2120

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2178

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2356

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1350

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1408

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1409 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1503

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1504 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1547

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1607

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1608 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1653

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1711



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2177

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2357

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2467

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2586

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2587 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2641

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2642 QRLQEAGILSAEELQRLAQGHTTV 2665



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1155 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1214

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1215 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1269

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1270 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1326

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1327 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1431 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1547

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1548 QVQVALETAQRSAE 1561



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1001 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1059

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1119

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1120 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1173

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1291

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1351

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1352 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1405

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1464

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1465 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2438 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2490

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2491 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2708


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  126 bits (316), Expect = 5e-29
 Identities = 129/488 (26%), Positives = 241/488 (49%), Gaps = 41/488 (8%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            ++ A+Q+ +  R R++ E+    +++    + +    + + + Q+S+   + EK KEE  
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697

Query: 78   RSLEARREKLRQLMQEEQDLLARELEELR-LSMNLQERRIREQHGKLK-----SAKEEQR 131
            R    RR K  +    +++L  +ELE+ R L+    ++R+  +   ++        E+QR
Sbjct: 1698 REAR-RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1756

Query: 132  KLIAEQL--LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA--TAEQENKRY 187
            +L+ E+L  L         K +E+E +L +        +  + + ++E+  T+E+  +R 
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1816

Query: 188  ENEYERARREALE----RMKAEEERRQL----EDKLQAEALLQQMEELKLKEV-EATKLK 238
            E E  R R  A E    R  AEE +RQ     ED  +  A  +++   KL  + EAT+LK
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876

Query: 239  KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
             E E  LK         E+  + E  R+ AE   F R +   Q ++    I+E L   R+
Sbjct: 1877 TEAEIALK---------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927

Query: 299  ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               + LE++       L +R QV  ++  +K + E+    +   E EL   +R  A++  
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR-IRSNAED-- 1984

Query: 359  EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVR-- 416
              R  E A   +AR R ++     R+++ +E+++++  A+EE+ + R+  +  +E ++  
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 417  -ELARREKEESEKLKSARKQELEAQVAERRLQAWE-----ADQQEEEEEEEARRVEQLSD 470
             E ARR +E +E+ +SAR+ +L  + A++RLQA E     A QQ+E+E ++  + EQ   
Sbjct: 2045 VEEARRLRERAEQ-ESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 471  ALLQQEAE 478
              L+ EAE
Sbjct: 2104 DQLRGEAE 2111



 Score =  103 bits (256), Expect = 5e-22
 Identities = 122/486 (25%), Positives = 230/486 (47%), Gaps = 54/486 (11%)

Query: 22   RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLE 81
            R+ E+E RL +Q     R  R++++ ++ + +     ++ ++    +RE  + ++R   E
Sbjct: 1369 RRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427

Query: 82   A-RREKLRQLMQEEQDLLARELEELRLSMNLQ---ERRIREQHGKLKSAKEEQRKLIAEQ 137
              RRE+     Q+++  +  EL++LR S   +   + R  E   + +   EE+ +++  Q
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487

Query: 138  LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARRE 197
            L     ++      E EL   +       E  + +K+Q +  AE+  ++ ++E +R R+ 
Sbjct: 1488 LEATERQRGGA---EGELQALRARA----EEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540

Query: 198  ALE---RMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
             +E   R+KAE E  +     + +  LQ +EEL+L+  EA       E  L+Q  E+ER 
Sbjct: 1541 EVELASRVKAEAEAAR-----EKQRALQALEELRLQAEEA-------ERRLRQA-EVERA 1587

Query: 255  EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
             + +  +E  ++ AE          A  + +T Q++  L+ +  +  A L +E E +   
Sbjct: 1588 RQVQVALETAQRSAEAEL---QSKRASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQ 1643

Query: 315  LARREQVMADVA-----WMKQAIEE-QLQLERAREAELQMLLREEAKEMWEKREAEWAR- 367
             A  E+   +       W  +A E  +L+L+    A+ + L + EA++  E+ E E  R 
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703

Query: 368  ----ERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL-------KHREQLIRNLEEVR 416
                E++ R R ++E    +Q+Q+ E   Q R A E+ L       +  EQ  + LEE  
Sbjct: 1704 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-- 1761

Query: 417  ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
            ELAR ++E +   +  ++QELEA++A+ R +       +   EEE+R   + S   L+ E
Sbjct: 1762 ELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819

Query: 477  AETMAE 482
            A    E
Sbjct: 1820 AGRFRE 1825



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 117/527 (22%), Positives = 241/527 (45%), Gaps = 65/527 (12%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            +R   Q  RQ E+  RL+Q  E+ ++    +   + K  + + + + +R+    Q E+  
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA----QAEQAA 2183

Query: 74   EEKRRSLEARREK--------LRQLMQEEQDL--LARELEELRLSMNLQERRIREQHGKL 123
              ++++ +A  EK        LRQ  Q EQ+L  L  +LEE     NL +  ++    + 
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243

Query: 124  KSAKEE----QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
              A  +    + +L + ++  E   K   ++      L  +   N+    +EE ++ +  
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303

Query: 180  AEQENK-----------RYENEYERARREALERMKAEEERRQLED--KLQAEA-LLQQME 225
            AE+  +           R   E + A++ AL     +E+ + +++  +L+AEA LLQQ +
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363

Query: 226  ELKLKEVEATKLKKEQ--ENLLKQRWELER-LEEERKQM-----EAFRQKAELGRFLRHQ 277
            EL  ++    +  KEQ  + L ++    +R LE ER++      EA R K  +    R Q
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423

Query: 278  YNAQ--LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARRE---------QVMADVA 326
              A+    R  +Q +E  E   R   A  EK    Q L + R++         + +A++ 
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483

Query: 327  WMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSA---RDRLMSEVLTGR 383
              K+ ++++ +L + +  E+Q + +E+  +  +  +  +  E+ +   R+R + +     
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543

Query: 384  QQQIQEKI-------EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE 436
            +Q  Q+++       E+ +R Q++  + R++L+ ++EE    ARR + E+E+    +++E
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQEE 2599

Query: 437  LEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            L+    +RR Q     ++ +   E+ + +E+   A L    E  A Q
Sbjct: 2600 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646



 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 128/515 (24%), Positives = 246/515 (47%), Gaps = 60/515 (11%)

Query: 17   NQQLARQR---EQEARLRQQWEQNSRYFRMS-DICSSKQAEWSSKTSYQRSMHAYQREKM 72
            + +L RQ+   E   R R+Q E+     + S +  ++ +AE   +    RS      + +
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN---AEDTL 1986

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            + +++  LEA R+  RQL  EE+       E ++ S+  +E   R++   L+  +  + K
Sbjct: 1987 RSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHV-----VNSWEMQKEEKKQQEATAEQEN--K 185
            +   + L E  ++ + +  ++  +  QK +      +++ +Q++E++ Q+   ++++   
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2104

Query: 186  RYENEYERARREALE----RMKAEEE----RRQLEDKLQAEALLQQMEELKLKEVE---- 233
            +   E E ARR A E    R++AE E    RRQ+E   +AE L Q  EE      +    
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQAQAA 2161

Query: 234  ATKLKKEQENLLKQRWELERLEEERKQ-----MEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            A KL+KE E    +R + E+    +KQ     ME  ++ AE  + LR +   +    T +
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLRQKAQVEQELTTLR 2219

Query: 289  IQ-EELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE-- 345
            +Q EE +  + +L   L++          +R QV  ++  ++  +EE  +L+   EAE  
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279

Query: 346  ---------LQMLLREEAKEMWEKRE----AEWARERSARDRLMSEVLTGRQQQIQEK-I 391
                      Q  L+EEA++M +  E       A + +AR R ++E    +Q+ + EK +
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339

Query: 392  EQNRRAQEES--LKHREQLIRNLEEV-RELARREKEESEKLKSARKQELEAQVAERRLQA 448
            ++  +A +E+  LK   +L++  +E+ +E ARR +E+ E++  A++   E Q  +R L+A
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQLAEETQGFQRTLEA 2397

Query: 449  WEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
                Q E   E E  ++     +  Q  AE  A++
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/480 (25%), Positives = 216/480 (45%), Gaps = 78/480 (16%)

Query: 23   QREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSL-- 80
            Q   E+ +++  +  + Y  ++ + +S+  ++ S+T  +        E+ + E+R  L  
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTL-TSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1391

Query: 81   -EARREKLRQLMQEEQDLLAR-ELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQL 138
             EA  EK RQL +      A+ E E   L   +QE  +R +   + +  ++Q++ I E+L
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA--QQQKRSIQEEL 1449

Query: 139  LYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE--RARR 196
                      +LR+            S E + + K +Q   AE+   R E E    R + 
Sbjct: 1450 ---------QQLRQ------------SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488

Query: 197  EALERMK--AEEERRQLEDKLQ-AEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
            EA ER +  AE E + L  + + AEA  +Q +E    E E  + + + E+  K++ E+E 
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQE----EAERLRRQVQDESQRKRQAEVEL 1544

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL-----EADRRILQALLEKED 308
                + + EA R+K                +R  Q  EEL     EA+RR+ QA +E+  
Sbjct: 1545 ASRVKAEAEAAREK----------------QRALQALEELRLQAEEAERRLRQAEVERAR 1588

Query: 309  ESQ-RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML--LREEAKEMWEKR-EAE 364
            + Q  L  A+R       +      E+  QLER+ + E   +  LREEA+   +++ EAE
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE 1648

Query: 365  WARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKE 424
             ARE + R+  +        + ++ +++    AQ++SL   E            A ++KE
Sbjct: 1649 RAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAE------------AEKQKE 1694

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            E+E+    R +  E  V +R L   E ++Q +  E  A++       L++  AET  EQG
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAET--EQG 1752



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 127/564 (22%), Positives = 249/564 (44%), Gaps = 98/564 (17%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNS-RYFRMSDICSSKQAEWSSKTSYQRSMHA------ 66
            Q   ++L ++ EQEA  R Q EQ + R  + +D    K  +++ +T  Q++         
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2218

Query: 67   --------YQREKMKEEKRRSLEARREKLRQLMQEEQDLLA-----RELEELRLSMNLQE 113
                    +Q+  + EE +R      E  RQ  Q E++L +      EL +L+  +  + 
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278

Query: 114  RRI--REQHGKLKSAKEEQRKL--IAEQLL-YEHWKKNNPKLREM-ELDLHQKHVVNSWE 167
            R +  R++    +  +EE  K+  +AE+        +   +LR++ E DL Q+  +    
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338

Query: 168  MQKEEKKQQEAT-----AEQENKRYENEYERARR----------------EALERMKAEE 206
            ++++ +  QEAT     AE   ++ E   E+ARR                +  +R    E
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2398

Query: 207  ERRQLEDKLQAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEER---- 258
             +RQLE   +AE L  ++ E+       E +A + +K+ E + ++    E   +E+    
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458

Query: 259  KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARR 318
            + +E  RQ+++       +  A+L R  +++Q+E     ++LQ       +S+ +   ++
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA----KLLQL------KSEEMQTVQQ 2508

Query: 319  EQVMADVAWMKQAI--EEQLQLERAR-----EAELQMLLREE---AKEMWEKREAEWARE 368
            EQ++ +   ++Q+   E+   L+R R     +A+L+ L ++E   A+++ E+++ +  + 
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568

Query: 369  RSARDRLMSEVLTGRQQQIQ------------EKIEQNRRAQEESL-----KHREQLIRN 411
               R RL++ +   R++Q +            +++EQ RR QEE L     + REQL + 
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QL 2627

Query: 412  LEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDA 471
            LEE    A    EE    + A  + L          A +    E E E     + +   A
Sbjct: 2628 LEEQHRAALAHSEEVTASQVAATKTL-----PNGRDALDGPAAEAEPEHSFDGLRRKVSA 2682

Query: 472  LLQQEAETMAEQGYRPKPYGHPKI 495
               QEA  ++ +  +    GH  +
Sbjct: 2683 QRLQEAGILSAEELQRLAQGHTTV 2706



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 102/434 (23%), Positives = 189/434 (43%), Gaps = 57/434 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLA------RELEELRLSMNLQERRIREQHGKLKSAKE 128
            E+   +E  RE++ QL++  Q +LA      RELE+L   +             L+ A+ 
Sbjct: 1196 ERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1255

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             Q ++ A  L      +   +  +  L+  ++H     E Q+  K+   A      K YE
Sbjct: 1256 RQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI-----KDYE 1310

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             +    + + LE + +  ++ +++    +E+++Q+  +L+    E T L  +    + + 
Sbjct: 1311 LQLVTYKAQ-LEPVASPAKKPKVQSG--SESVIQEYVDLRTHYSELTTLTSQYIKFISET 1367

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED 308
              L R+EEE +              L  Q  A+   R  +++  LE  R++ +A  + + 
Sbjct: 1368 --LRRMEEEER--------------LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411

Query: 309  ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARE 368
            +++R     ++++  +V   ++A  +  Q +R+ + ELQ L +    E+  K     A E
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471

Query: 369  RSARDRLMSEVLTGRQQ--------------------QIQEKIEQNRRAQEESLKHREQL 408
            RS R R+  E+   R Q                    + +E   Q R+AQEE+ + R Q+
Sbjct: 1472 RS-RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530

Query: 409  IRNLEEVR----ELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARR 464
                +  R    ELA R K E+E  +   KQ     + E RLQA EA+++  + E E  R
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAR--EKQRALQALEELRLQAEEAERRLRQAEVERAR 1588

Query: 465  VEQLSDALLQQEAE 478
              Q++    Q+ AE
Sbjct: 1589 QVQVALETAQRSAE 1602



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 121/527 (22%), Positives = 227/527 (43%), Gaps = 64/527 (12%)

Query: 7    PSYWCSQQRLNQQLARQREQE------ARLRQQWEQNSRYFRMSDICSSKQAEWS---SK 57
            P+  C+Q+   QQ A Q E E      ARL  + E+       S    + ++E      K
Sbjct: 1042 PARECAQRIAEQQKA-QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1100

Query: 58   TSYQRSMHAYQREKMKEEKR--RSLEARREKLR---QLMQEEQDLLAR--ELEELRLSMN 110
                RS+ A   EK+K      R  +   E LR   + ++E Q + A   ELE  + S+ 
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK 1160

Query: 111  LQERRIREQHGKLKSAKEEQR--KLIAEQLLYEHWKKNNPKLREMELDLHQKHV---VNS 165
                +   Q     + ++E R  + + E+L   H +      R++E++  ++ V   +  
Sbjct: 1161 KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE------RDVEVERWRERVAQLLER 1214

Query: 166  WE--MQKEEKKQQEATAEQENKRYENEYE----------RARREALERMKAEEERRQLED 213
            W+  + + + +Q+E        RY  E            R R+E ++ M   + +   E 
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQME-----AFRQKA 268
              Q +ALL+++E    K  E  +  K+  N +K  +EL+ L   + Q+E     A + K 
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQ-LVTYKAQLEPVASPAKKPKV 1332

Query: 269  ELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWM 328
            + G     Q    L     ++        + +   L + +E +RL   +R +    +A +
Sbjct: 1333 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV 1392

Query: 329  KQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            + A+E+Q QL  A  A+ +     EAKE+ ++ + E  R   A      +     ++ IQ
Sbjct: 1393 EAALEKQRQLAEAH-AQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ-----KRSIQ 1446

Query: 389  EKIEQNRRAQEESLKHR-------EQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
            E+++Q R++ E  ++ +       E+    +EE   + R + E +E+ +   + EL+A  
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL- 1505

Query: 442  AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
               R +A EA+ Q+ + +EEA R+ +      Q++ +   E   R K
Sbjct: 1506 ---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 51/345 (14%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEE 75
            +++  AR  E   R R+Q E+       +++ + ++         QR    +  E+++E 
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478

Query: 76   KRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIA 135
                LE  +EKL    Q+E  LL  + EE++     QE+ ++E     +S   E+  L+ 
Sbjct: 2479 IAE-LEREKEKL----QQEAKLLQLKSEEMQTVQ--QEQLLQETQALQQSFLSEKDSLLQ 2531

Query: 136  EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQE----------ATAEQENK 185
             +   E  K    KL +    L Q  V  + ++++E+++QQ+          A+ E+  +
Sbjct: 2532 RERFIEQEKA---KLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584

Query: 186  RYENEYERARREALERMKAEEERRQLEDKL----------------QAEALLQQMEELKL 229
            R     E  RR+  E  + E++RRQ E+ L                Q  A L   EE+  
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644

Query: 230  KEVEATK-LKKEQENLLKQRWELE----------RLEEERKQMEAFRQKAELGRFLRHQY 278
             +V ATK L   ++ L     E E          ++  +R Q        EL R  +   
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2704

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMA 323
                  R + ++  L+    I   LL+  +E   ++ A + Q+++
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  123 bits (309), Expect = 3e-28
 Identities = 122/519 (23%), Positives = 245/519 (47%), Gaps = 61/519 (11%)

Query: 12  SQQRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQA-----EWSSKTSYQRSMH 65
           SQ  + Q     R+  +RL   W+      + +S + + K+      E  +K     S+ 
Sbjct: 210 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 269

Query: 66  AYQREKMKEEKRRSLEARREKLRQLMQEEQDL------LARELEELRLSMNLQERRIREQ 119
            Y+     EE +      +EKL+ +  E+ ++      L R+LE  +L +  Q+ +    
Sbjct: 270 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 329

Query: 120 HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
           H   K  +    KL A+    E W + N +  E      Q+  +  WE + +E  Q+E  
Sbjct: 330 HLG-KELQSVSAKLQAQVEENELWNRLNQQQEEKMW--RQEEKIQEWEEKIQE--QEEKI 384

Query: 180 AEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
            EQE K  E E +  R+E +   K E+ RRQ E   + E  +++ EE+  ++ E  K+++
Sbjct: 385 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE--KIRE 442

Query: 240 EQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
            +E + +Q  ++   EE+R++ E  R++ +     R +  A++ R+ ++I+E+ E  R  
Sbjct: 443 LEEKMHEQE-KIREQEEKRQEEEKIREQEK-----RQEQEAKMWRQEEKIREQEEKIREQ 496

Query: 300 LQALLEKED---ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA--ELQMLLREEA 354
            + +  +E+   E +++    + Q   ++   ++ I EQ ++ R +E   E +  +R++ 
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556

Query: 355 KEMW--------------EKREAEWARERSARDR-----------LMSEVLTGRQQQIQE 389
           ++MW              E+ E  W +E   R++              E +T  Q++   
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616

Query: 390 KIEQNRRAQEESLKHREQLIRNLEE-VRELARREKEESEKLKSARK--QELEAQVAERRL 446
           + E+    QEE ++ +E+ +R  EE +RE  ++ +E+ EK++   +  QE E ++ E+  
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 676

Query: 447 QAWEADQQEEEEEEEARRVEQL---SDALLQQEAETMAE 482
           +  E +++ +E+EE+ RR E+     +  L+Q+ E M E
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 715



 Score =  115 bits (287), Expect = 1e-25
 Identities = 93/400 (23%), Positives = 210/400 (52%), Gaps = 41/400 (10%)

Query: 86  KLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKK 145
           +L Q  +E+      +++E    +  QE +IREQ  K++  +E+ R+   E+++   W+K
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR--QEEMM---WEK 408

Query: 146 NNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAE 205
                R+ E+          WE +++ ++Q+E   E+E K  E E +   +E   +++ +
Sbjct: 409 EEKMRRQEEM---------MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE---KIREQ 456

Query: 206 EERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFR 265
           EE+RQ E+K++ +   Q+ E    ++ E  K+++++E + +Q  ++ R EE+  + E  R
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEE--KIREQEEKIREQEEKMWRQEEKIHEQEKIR 514

Query: 266 QKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE--SQRLHLARREQVMA 323
           ++       + Q   ++ R+ ++I+E+ E  R+  + + E+E++   Q   + R+E+ M 
Sbjct: 515 EEE------KRQEQEEMWRQEEKIREQEEIWRQ-KEKIHEQEEKIRKQEEKMWRQEEKMH 567

Query: 324 DVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGR 383
           D     +  EE++  +  +  E +  +RE+ +++ E+ E    +E    ++   E +  +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQ--EEKMCEQ 625

Query: 384 QQQIQEKIEQNRRAQEESLKHREQLIRNLEE-VRELARREKEESEKL---------KSAR 433
           ++++QE+ E+ RR QEE ++ +E+ IR  EE +RE     +E+ EK+         +  +
Sbjct: 626 EEKMQEQEEKMRR-QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684

Query: 434 KQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALL 473
            QE E ++  +  + WE + +  ++EE+ +  ++  +A +
Sbjct: 685 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724



 Score =  110 bits (274), Expect = 4e-24
 Identities = 102/416 (24%), Positives = 210/416 (50%), Gaps = 43/416 (10%)

Query: 28  ARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE--EKRRSLEARRE 85
           A+L+ Q E+N  + R++     K      K          Q EK++E  EK R  E +  
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 399

Query: 86  KLRQLMQEEQDLLARELE---ELRLSMNLQERRIREQHGKLKSAKEE--QRKLIAEQLLY 140
           +  ++M E+++ + R+ E   E    M  QE  + E+  K++  +E+  +++ I EQ   
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ--- 456

Query: 141 EHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALE 200
           E  ++   K+RE E    Q+     W  +++ ++Q+E   EQE K +  E E+   +  E
Sbjct: 457 EEKRQEEEKIREQEK--RQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE-EKIHEQ--E 511

Query: 201 RMKAEEERRQLEDKLQAEALLQQMEEL-KLKEVEATKLKKEQENLLKQRWELERLEEE-R 258
           +++ EE+R++ E+  + E  +++ EE+ + KE    K+ +++E + KQ  ++ R EE+  
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKE----KIHEQEEKIRKQEEKMWRQEEKMH 567

Query: 259 KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKED--ESQRLHLA 316
            Q E  R++ E           ++ R+ ++I+E+ E  R   + + E+E+  + Q   + 
Sbjct: 568 DQEEKIREQEE-----------KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMG 616

Query: 317 RREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLM 376
            +E+ M +     Q  EE+++ +  +  E +  +RE+ +++ E+ E    +E    ++  
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ-- 674

Query: 377 SEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSA 432
            E +  +++++QE+ E+ RR QEE +  +E  +R  EE      + +E  E L++A
Sbjct: 675 EEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEE------KMQEHQEHLEAA 723



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 106/434 (24%), Positives = 213/434 (49%), Gaps = 59/434 (13%)

Query: 73  KEEKRRSLEARREKLRQLMQEEQDLLAR---------ELEELRLSMNLQERRIREQHGKL 123
           K E + +L   +  ++QL  E +DL++R         ELE+   ++  Q+++      +L
Sbjct: 200 KTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEEL 259

Query: 124 KSAKEE-QRKLIAEQLLYEHWKKNNPKLREM---------ELDLHQKHVVNSWEMQKEEK 173
              ++    +L    +  E  K+ N KL+E          E+ L+ K +    E  K   
Sbjct: 260 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLL 319

Query: 174 KQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
            QQ+  AE ++   E +   A+      ++A+ E  +L ++L      QQ EE   ++ E
Sbjct: 320 PQQQLQAEADHLGKELQSVSAK------LQAQVEENELWNRLN-----QQQEEKMWRQEE 368

Query: 234 ATKLKKEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
             K+++ +E + +Q  ++   EE+ R+Q E  R++ E+      +   ++ R+ + + E+
Sbjct: 369 --KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM----MWEKEEKMRRQEEMMWEK 422

Query: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352
            E  RR  + + EKE++ + L     E+ M +   +++  E++ + E+ RE E +   +E
Sbjct: 423 EEKMRRQEEMMWEKEEKIREL-----EEKMHEQEKIREQEEKRQEEEKIREQEKR---QE 474

Query: 353 EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQI--QEKI-EQNRRAQEESLKHREQLI 409
           +  +MW  R+ E  RE+  + R   E +  ++++I  QEKI E+ +R ++E +  +E+ I
Sbjct: 475 QEAKMW--RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 532

Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
           R  EE+     +  E+ EK+   RKQE +    E ++     DQ+E+  E+E +   Q  
Sbjct: 533 REQEEIWRQKEKIHEQEEKI---RKQEEKMWRQEEKMH----DQEEKIREQEEKVWRQ-- 583

Query: 470 DALLQQEAETMAEQ 483
           +  ++++ E + EQ
Sbjct: 584 EEKIREQEEKIREQ 597



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 94/428 (21%), Positives = 182/428 (42%), Gaps = 87/428 (20%)

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
           Q++ H +Q     E  RR LEA+   +R        +L  +  EL++++   +  +++  
Sbjct: 172 QKASHQHQ-----EALRRELEAQVHTIR--------ILTCQKTELQMALYYSQHAVKQLE 218

Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           G       E R LI+                     LH     +SW+   E ++   A A
Sbjct: 219 G-------EARDLISR--------------------LH-----DSWKFAGELEQALSAVA 246

Query: 181 EQENK--RYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLK 238
            Q+ K  RY  E  + R    + +  E  R  + D+   E   +  E+L+L E E ++++
Sbjct: 247 TQKKKADRYIEELTKER----DALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 302

Query: 239 KEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
              + L                    ++K E  + L  Q   QL      + +EL++   
Sbjct: 303 LNVKEL--------------------KRKLERAKLLLPQQ--QLQAEADHLGKELQSVSA 340

Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
            LQA +E+ +   RL+  + E++      + Q  EE++Q +  +  E +  +RE+ ++M 
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKI-QEWEEKIQEQEEKIREQEEKIREQEEKMR 399

Query: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
            + E  W +E   R          RQ+++  + E+  R QEE +  +E+ IR LEE    
Sbjct: 400 RQEEMMWEKEEKMR----------RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 449

Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
             + +E+ EK +   K   + +  E+  + W   +QEE+  E+  ++ +  + + +QE +
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMW---RQEEKIREQEEKIREQEEKMWRQEEK 506

Query: 479 TMAEQGYR 486
              ++  R
Sbjct: 507 IHEQEKIR 514



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 87/350 (24%), Positives = 163/350 (46%), Gaps = 75/350 (21%)

Query: 13  QQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSDICSSKQAE--------WSSKTSY 60
           ++++ +Q  + REQE ++R+Q    WE+  +  R  ++   K+ +        W  +   
Sbjct: 381 EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI 440

Query: 61  ---QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIR 117
              +  MH  ++ + +EEKR+  E  RE+ ++  QE++  + R+ E++R     QE +IR
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIRE----QEEKIR 494

Query: 118 EQHGKLKSAKE---EQRKLIAEQLLYEH---WKKNNPKLREMELDLHQKHVVNSWE--MQ 169
           EQ  K+   +E   EQ K+  E+   E    W++   K+RE E    QK  ++  E  ++
Sbjct: 495 EQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE-KIREQEEIWRQKEKIHEQEEKIR 553

Query: 170 KEEKK------------------------QQEATAEQENKRYENE-----YERARREALE 200
           K+E+K                        Q+E   EQE K  E E      E   +E  E
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613

Query: 201 RMKAEEER--------RQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR---W 249
           +M  +EE+        ++ E+K++ +    + +E K++E E  K+++++E + +Q    W
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQE-EKIREQEEMMQEQEEKMW 672

Query: 250 ELE----RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEA 295
           E E      EE+ ++ E   ++ E   + +     Q   + Q+ QE LEA
Sbjct: 673 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 39/153 (25%), Positives = 78/153 (50%), Gaps = 13/153 (8%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++++ +Q  + REQE ++R+Q E              K  E   K   Q      Q 
Sbjct: 581 WRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640

Query: 70  EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
           EK++E++++ +  + EK+R     EQ+ + +E EE    M  QE ++ EQ  K++  +E+
Sbjct: 641 EKIREQEKK-IREQEEKIR-----EQEEMMQEQEE---KMWEQEEKMCEQEEKMQEQEEK 691

Query: 130 QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHV 162
            R+   E+ ++E  ++   + +E ++  HQ+H+
Sbjct: 692 MRR--QEEKMWE--QEVRLRQQEEKMQEHQEHL 720


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  123 bits (308), Expect = 4e-28
 Identities = 122/512 (23%), Positives = 243/512 (47%), Gaps = 61/512 (11%)

Query: 12  SQQRLNQQLARQREQEARLRQQWEQNSRYFR-MSDICSSKQA-----EWSSKTSYQRSMH 65
           SQ  + Q     R+  +RL   W+      + +S + + K+      E  +K     S+ 
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 208

Query: 66  AYQREKMKEEKRRSLEARREKLRQLMQEEQDL------LARELEELRLSMNLQERRIREQ 119
            Y+     EE +      +EKL+ +  E+ ++      L R+LE  +L +  Q+ +    
Sbjct: 209 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268

Query: 120 HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
           H   K  +    KL A+    E W + N +  E      Q+  +  WE + +E  Q+E  
Sbjct: 269 HLG-KELQSVSAKLQAQVEENELWNRLNQQQEEKMW--RQEEKIQEWEEKIQE--QEEKI 323

Query: 180 AEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
            EQE K  E E +  R+E +   K E+ RRQ E   + E  ++++EE+  ++ E  K+++
Sbjct: 324 REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE--KIRE 381

Query: 240 EQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRI 299
            +E + +Q  ++   EE+R++ E  R++ +     R +  A++ R+ ++I+E+ E  R  
Sbjct: 382 LEEKMHEQE-KIREQEEKRQEEEKIREQEK-----RQEQEAKMWRQEEKIREQEEKIREQ 435

Query: 300 LQALLEKED---ESQRLHLARREQVMADVAWMKQAIEEQLQLERAREA------------ 344
            + +  +E+   E +++    + Q   ++   ++ I EQ ++ R +E             
Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495

Query: 345 ----------ELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQN 394
                     + +  +RE+ ++MW  R+ E  RE+  + R   E +  +++ +QE+ E+ 
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMW--RQEEKIREQEEKIREQEEKIREQEEMMQEQ-EEK 552

Query: 395 RRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQ 454
              QEE ++ +E++ R  E++RE   + +E+ EK+   R+QE +    E +++  E   Q
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI---REQEEKIWEQEEKIREQEEMMQ 609

Query: 455 EEEE---EEEARRVEQLSDALLQQEAETMAEQ 483
           E+EE   E+E +  EQ  +  +Q++ E M  Q
Sbjct: 610 EQEEKMWEQEEKMCEQ--EEKMQEQEEKMRRQ 639



 Score =  117 bits (294), Expect = 2e-26
 Identities = 110/469 (23%), Positives = 237/469 (50%), Gaps = 58/469 (12%)

Query: 12  SQQRLNQQLARQREQEARL---RQQWEQNSRYF--RMSDICSSKQAEWSSKTSYQRSMHA 66
           S+ +LN +  +++ + A+L   +QQ +  + +    +  + +  QA+      + R ++ 
Sbjct: 238 SEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-LNQ 296

Query: 67  YQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL---QERRIREQHG 121
            Q EKM  +EEK +  E + ++  + ++E+++ +  + E++R    +   +E ++R Q  
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE 356

Query: 122 KLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK---KQQEA 178
            +   +E+ R+L  E++++E       K+RE+E  +H++  +   E +++E+   ++QE 
Sbjct: 357 MMWEKEEKMRRL--EEMMWE----KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410

Query: 179 TAEQENKRYENE-----YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
             EQE K +  E      E   RE  ++M  +EE+   ++K++ E   Q+ EE+  +E +
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 470

Query: 234 ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
                +EQE + +Q+ ++   E+ RKQ E   ++ E           ++  + ++I+E+ 
Sbjct: 471 I----REQEEIWRQKEKMHEQEKIRKQEEKVWRQEE-----------KMHDQEEKIREQE 515

Query: 294 EADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
           E   R  + + E+E++ +      REQ            EE +Q +  +  E +  ++E+
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQ------------EEMMQEQEEKMGEQEEKMQEQ 563

Query: 354 AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
            K    +R+ E  RE+  + R   E +  ++++I E+ E+  R QEE ++ +E+ +   E
Sbjct: 564 EKM---RRQEEKIREQEEKIREQKEKIREQEEKIWEQ-EEKIREQEEMMQEQEEKMWEQE 619

Query: 414 EVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA 462
           E  ++  +E++  E+ +  R+QE +    E RL+  E   QE +E  EA
Sbjct: 620 E--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666



 Score =  113 bits (283), Expect = 3e-25
 Identities = 109/454 (24%), Positives = 223/454 (49%), Gaps = 37/454 (8%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
           K A+   K     S  +  +  +KE KR+   A+    +Q +Q E D L +EL+ +   +
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL 281

Query: 110 NLQERRIREQHGKLKSAKEE----QRKLIAE-----QLLYEHWKKNNPKLREMELDLHQK 160
             Q     E   +L   +EE    Q + I E     Q   E  ++   K+RE E  + ++
Sbjct: 282 QAQVEE-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340

Query: 161 HVVNSWEMQKEEKKQQEATAEQENK--RYEN---EYERARREALERMKAEEERRQLEDKL 215
             +  WE +++ ++Q+E   E+E K  R E    E E   RE  E+M  +E+ R+ E+K 
Sbjct: 341 EEM-MWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 399

Query: 216 QAEALLQQMEELKLKEV----EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG 271
           Q E  +++ E+ + +E     +  K+++++E + +Q  ++ R EE+  + E  R++    
Sbjct: 400 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE--- 456

Query: 272 RFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQA 331
              + Q   ++ R+ ++I+E+ E  R+  +   +++   Q   + R+E+ M D     + 
Sbjct: 457 ---KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513

Query: 332 IEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI 391
            EE++  +  +  E +  +RE+ +++ E+ E    +E    +++  +    ++Q+   + 
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE----EKMGEQEEKMQEQEKMRRQ 569

Query: 392 EQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEA 451
           E+  R QEE ++ +++ IR  EE       E+EE  + +    QE E ++ E+  +  E 
Sbjct: 570 EEKIREQEEKIREQKEKIREQEE----KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625

Query: 452 DQQEEEEEEEARRVEQL---SDALLQQEAETMAE 482
           +++ +E+EE+ RR E+     +  L+Q+ E M E
Sbjct: 626 EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659



 Score =  107 bits (266), Expect = 3e-23
 Identities = 103/439 (23%), Positives = 214/439 (48%), Gaps = 80/439 (18%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++++ +   + +EQE ++R+Q E              K  E   K   Q  M   + 
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEE--------------KIREQEEKMRRQEEMMWEKE 348

Query: 70  EKMKEEKRRSLEARREKLRQL--MQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAK 127
           EKM+ ++    E + EK+R+L  M  E++   RELEE    M+ QE +IREQ  K     
Sbjct: 349 EKMRRQEEMMWE-KEEKMRRLEEMMWEKEEKIRELEE---KMHEQE-KIREQEEK----- 398

Query: 128 EEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRY 187
                           ++   K+RE E    Q+     W  +++ ++Q+E   EQE K +
Sbjct: 399 ----------------RQEEEKIREQE--KRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440

Query: 188 ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEEL---KLKEVEATKLKKEQENL 244
             E E+   +  E+++ EE+R++ E+  + E  +++ EE+   K K  E  K++K++E +
Sbjct: 441 RQE-EKIHEQ--EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497

Query: 245 LKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
            +Q  ++   EE+ ++ E                  ++ R+ ++I+E+ E  R   + + 
Sbjct: 498 WRQEEKMHDQEEKIREQE-----------------EKMWRQEEKIREQEEKIREQEEKIR 540

Query: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE--AELQMLLREEAKEMWEKRE 362
           E+E+  Q      +E+ M +    ++ ++EQ ++ R  E   E +  +RE+ +++ E+ E
Sbjct: 541 EQEEMMQ-----EQEEKMGE---QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592

Query: 363 AEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARRE 422
             W +E   R++   E++  +++++ E+ E+    +E+  +  E++ R  E++ E   R 
Sbjct: 593 KIWEQEEKIREQ--EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650

Query: 423 KEESEKLKSARKQELEAQV 441
           +++ EK++   ++ LEA +
Sbjct: 651 RQQEEKMQE-HQEHLEAAI 668



 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 117/490 (23%), Positives = 234/490 (47%), Gaps = 65/490 (13%)

Query: 17  NQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEK 76
           ++Q A  + QEA LR++ E      R   I + ++ E      Y  S HA ++  ++ E 
Sbjct: 109 DEQKASHQHQEA-LRRELEAQVHTIR---ILTCQKTELQMALYY--SQHAVKQ--LEGEA 160

Query: 77  RRSLEARREKLRQLMQEEQDLLA---------RELEELR-----LSMNLQERRIREQHGK 122
           R  +    +  +   + EQ L A         R +EEL      LS+ L    I ++  K
Sbjct: 161 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 220

Query: 123 LKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEAT 179
            K+AK +++  + E    E   + K+   KL   +L L Q+ +    E     K+ Q  +
Sbjct: 221 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL--QAEADHLGKELQSVS 278

Query: 180 AEQENKRYENE-YERARREALERMKAEEER-RQLEDKLQAEALLQQMEELKLKEVEATKL 237
           A+ + +  ENE + R  ++  E+M  +EE+ ++ E+K+Q +    + +E K++E E  K+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE-KM 337

Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
           ++++E +    WE E  E+ R+Q E   +K E  R L      +   + ++++E++    
Sbjct: 338 RRQEEMM----WEKE--EKMRRQEEMMWEKEEKMRRLEEMM-WEKEEKIRELEEKMHEQE 390

Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
           +I +   EK  E +++    + Q      W ++        E+ RE E +  +RE+ K+M
Sbjct: 391 KIREQE-EKRQEEEKIREQEKRQEQEAKMWRQE--------EKIREQEEK--IREQEKKM 439

Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRE 417
           W + E    +E+             R+++ +++ E+  R QEE ++ +E++ R  E++ E
Sbjct: 440 WRQEEKIHEQEKI------------REEEKRQEQEEMWR-QEEKIREQEEIWRQKEKMHE 486

Query: 418 LARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEEEEEEARRVEQL---SDALL 473
             +  K+E +  +   K  + E ++ E+  + W  +++  E+EE+ R  E+     + ++
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546

Query: 474 QQEAETMAEQ 483
           Q++ E M EQ
Sbjct: 547 QEQEEKMGEQ 556



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 104/438 (23%), Positives = 199/438 (45%), Gaps = 49/438 (11%)

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
           Q++ H +Q     E  RR LEA+   +R        +L  +  EL++++   +  +++  
Sbjct: 111 QKASHQHQ-----EALRRELEAQVHTIR--------ILTCQKTELQMALYYSQHAVKQLE 157

Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           G       E R LI+   L++ WK           +L Q     + + +K ++  +E T 
Sbjct: 158 G-------EARDLISR--LHDSWKFAG--------ELEQALSAVATQKKKADRYIEELTK 200

Query: 181 EQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
           E++    E        E L+   A+ +E+ QL +  ++E  L  ++ELK K +E  KL  
Sbjct: 201 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-VKELKRK-LERAKLLL 258

Query: 240 EQENLLKQRWEL-ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
            Q+ L  +   L + L+    +++A  ++ EL   L  Q   ++ R+ ++IQE  E  + 
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE 318

Query: 299 ILQALLEKEDE--SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKE 356
             + + E+E++   Q   + R+E++M    W K   EE+++ +     E +  +R   + 
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMM----WEK---EEKMRRQEEMMWEKEEKMRRLEEM 371

Query: 357 MWEKREA-EWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE- 414
           MWEK E      E+      + E    RQ++ + + ++ R+ QE  +  +E+ IR  EE 
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431

Query: 415 VRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQ 474
           +RE  ++   + EK+    K   E    E+R +  E  +QEE+  E+     Q      Q
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREE----EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ 487

Query: 475 QEAETMAEQGYRPKPYGH 492
           ++     E+ +R +   H
Sbjct: 488 EKIRKQEEKVWRQEEKMH 505


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score =  107 bits (267), Expect = 3e-23
 Identities = 101/449 (22%), Positives = 217/449 (48%), Gaps = 68/449 (15%)

Query: 15  RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
           ++ +Q  + REQE ++R+Q  Q             ++ +   +    R      RE+  +
Sbjct: 53  QVREQEGQVREQEGQVREQEGQ----------VREQEGQVREQEGQVREQEGQVREQEGQ 102

Query: 75  EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
            + +  + R ++ +   QE Q      + E    +  QE ++REQ G+++    EQ   +
Sbjct: 103 VREQEGQVREQEGQVREQEGQ------VREQEGQVREQEGQVREQEGQVR----EQEGQV 152

Query: 135 AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERA 194
            EQ      ++   ++RE E  +         E + + ++Q+    EQE +  E E +  
Sbjct: 153 REQ--EGQVREQEGQVREQEGQVR--------EQEGQVREQEGQVREQEGQMGEQEGQMG 202

Query: 195 RREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
            +E  E+M  +EE+ Q +++   E    Q E+++ +E +   + +++E + KQ  ++++ 
Sbjct: 203 EQE--EQMGEQEEQMQKQEEQMGE----QEEQMRKQEEQ---MGEQEEQVQKQEEQVQKQ 253

Query: 255 EEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
           EE+ RKQ E  R++ E    +R Q    L ++ Q  QEE   ++   + + E+E++ +  
Sbjct: 254 EEQMRKQEEQMREQEEQ---MREQEEQMLKQKEQTEQEEQTGEQE--EQMREQEEQMREQ 308

Query: 314 HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
               REQ            EEQ++ +  +  + +  + E+ ++MWE++E  W +E     
Sbjct: 309 EEQMREQ------------EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE----- 351

Query: 374 RLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSAR 433
               E +  +++Q+Q++ EQ R+ +E+  K  EQ+ +  E++R+   +  E+ E++   +
Sbjct: 352 ----EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQK 407

Query: 434 KQ--ELEAQVAERRLQAWEADQQEEEEEE 460
           +Q  E E Q+ E++ Q  + ++   E++E
Sbjct: 408 EQMREQEEQMGEQKEQMRKQEEHMGEQKE 436



 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 100/432 (23%), Positives = 217/432 (50%), Gaps = 33/432 (7%)

Query: 71  KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNL------QERRIREQHGKLK 124
           ++  E+ +   A  ++  QL++ E+  +   ++EL+  +        QE ++REQ G+++
Sbjct: 3   RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62

Query: 125 SAK---EEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
             +    EQ   + EQ      ++   ++RE E  + ++      E + + ++Q+    E
Sbjct: 63  EQEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVRE 119

Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
           QE +  E E +   +E   R +  + R Q     + E  +++ E  +++E E     +EQ
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQV--REQ 176

Query: 242 ENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQ 301
           E  ++++ E +  E+E +  E   Q  E    +  Q   Q+ ++ +Q+ E+ E  R+  +
Sbjct: 177 EGQVREQ-EGQVREQEGQMGEQEGQMGEQEEQMGEQ-EEQMQKQEEQMGEQEEQMRKQEE 234

Query: 302 ALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQMLLREEAKEMWE 359
            + E+E++ Q+    + EQV      M++  EEQ+  Q E+ RE E QML ++E  E  E
Sbjct: 235 QMGEQEEQVQK----QEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQTEQEE 289

Query: 360 K--REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEV-- 415
           +   + E  RE+  + R   E +  +++Q++E+ EQ  + +E+  + +EQ+    E++  
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349

Query: 416 --RELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD--A 471
              ++  +E++  ++ +  RKQE + +  E +++  E +Q  ++EE+   + EQ+ +   
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQE-EQMRKQEEQMGEQKEQMGEQKE 408

Query: 472 LLQQEAETMAEQ 483
            ++++ E M EQ
Sbjct: 409 QMREQEEQMGEQ 420



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 65/245 (26%), Positives = 120/245 (48%), Gaps = 27/245 (11%)

Query: 13  QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
           ++++ +Q  +  EQE ++R+Q EQ        +    KQ E   K   Q      Q E+M
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGE----QEEQVQKQEEQVQK---QEEQMRKQEEQM 264

Query: 73  KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
           +E++ +  E   + L+Q  Q EQ+    E EE    M  QE ++REQ  +++  +E+ R+
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEE---QMREQEEQMREQEEQMREQEEQMRE 321

Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
                   E   K   ++ E +  +        WE +++  KQ+E   EQE +  + E E
Sbjct: 322 ------QEEQMGKQEEQMWEQKEQM--------WEQKEQMWKQEEQMGEQEEQMQKQE-E 366

Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELE 252
           + R++  +  K EE+ R+ E++++ +   +QM E K +  E  +  +EQE  + ++ E  
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQE--EQMGEQKEQMGEQKEQMREQEEQMGEQKEQM 424

Query: 253 RLEEE 257
           R +EE
Sbjct: 425 RKQEE 429



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 62/277 (22%), Positives = 127/277 (45%), Gaps = 27/277 (9%)

Query: 212 EDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER--LEEERKQMEAFRQKAE 269
           E+  +  A LQ  EEL+L E E ++++   + L K++ E ++  L +E +  E   Q  E
Sbjct: 7   EELKEKNAELQ--EELQLVETEKSEIQLHIKEL-KRKLETDKIPLPQEGQVREQEGQVRE 63

Query: 270 LGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMK 329
               +R Q   Q+  +  Q++E+    R     + E+E + +      REQ         
Sbjct: 64  QEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ--------- 113

Query: 330 QAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQE 389
              E Q++ +  +  E +  +RE+  ++ E+      RE+  + R     +  ++ Q++E
Sbjct: 114 ---EGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVRE 168

Query: 390 KIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAW 449
           + E   R QE  ++ +E  +R  E+  ++  +E +  E+ +   +QE + Q  E ++   
Sbjct: 169 Q-EGQVREQEGQVREQEGQVR--EQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM--- 222

Query: 450 EADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYR 486
             +Q+E+  ++E +  EQ      Q+E     E+  R
Sbjct: 223 -GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258



 Score = 36.2 bits (82), Expect = 0.071
 Identities = 22/88 (25%), Positives = 42/88 (47%), Gaps = 4/88 (4%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQR 69
           W  ++++ +Q  + ++QE ++R+Q EQ     R  +    KQ E   K   Q      Q 
Sbjct: 348 WKQEEQMGEQEEQMQKQEEQVRKQEEQ----MRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403

Query: 70  EKMKEEKRRSLEARREKLRQLMQEEQDL 97
            + KE+ R   E   E+  Q+ ++E+ +
Sbjct: 404 GEQKEQMREQEEQMGEQKEQMRKQEEHM 431


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  105 bits (263), Expect = 7e-23
 Identities = 121/458 (26%), Positives = 225/458 (49%), Gaps = 69/458 (15%)

Query: 61   QRSMHAYQREKMKEEKR-RSLEARREKLRQLMQEEQDLLARELEELRLSMNLQ----ERR 115
            Q  +    R+K+    R R LE  +  L++  QEE++   + LE+  L++  Q    +++
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQE-QQEEEEEARKNLEKQVLALQSQLADTKKK 1379

Query: 116  IREQHGKLKSAKEEQRKLIAEQ-----------LLYEHWKKNNPKLREMELDL-----HQ 159
            + +  G ++S +E ++KL+ +            L Y+  +K   +L++   DL     HQ
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439

Query: 160  KHVVNSWEMQKEEKKQQEATAEQEN--KRYENEYERARREALER-MKAEEERRQLEDKLQ 216
            + V ++  ++K++KK  +  AE+++   RY  E +RA  EA E+  KA    R LE+ L+
Sbjct: 1440 RQVASN--LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALE 1497

Query: 217  A--------EALLQQMEEL---------KLKEVEATKLKKEQENLLKQRWELERLEEERK 259
            A        + L   ME+L          + E+E +K   EQ+ + + R +LE LE+E +
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ-VEEMRTQLEELEDELQ 1556

Query: 260  QMEAFRQKAELG-RFLRHQYNAQLSRRTQQIQEE---LEADRRILQALLEKEDESQRLHL 315
              E  + + E+  + ++ Q+   L  R +Q +E+   L    R L+A LE E + + L +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616

Query: 316  ARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRL 375
            A ++++  D+  ++  IE      +AR+  ++ L + +A+    +RE E A  R++RD +
Sbjct: 1617 ASKKKMEIDLKDLEAQIE---AANKARDEVIKQLRKLQAQMKDYQRELEEA--RASRDEI 1671

Query: 376  MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSA--- 432
             ++  +   ++  + +E      +E L   E+  R+ E+ R+    E   S   KSA   
Sbjct: 1672 FAQ--SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 433  RKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
             K+ LEA++A          Q EEE EEE   +E L+D
Sbjct: 1730 EKRRLEARIA----------QLEEELEEEQSNMELLND 1757



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 108/483 (22%), Positives = 220/483 (45%), Gaps = 72/483 (14%)

Query: 20   LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            LAR  E+    ++++E+ ++  R  M D+ SSK           +++H  ++ K      
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKD-------DVGKNVHELEKSK------ 1534

Query: 78   RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHG--KLKSAKEEQRKLI 134
            R+LE + E++R  ++E E +L A E  +LRL +N+Q  + + +          EE+++L+
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594

Query: 135  AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQENKRYEN 189
             +Q+            RE+E +L  +    +  +  ++K     K  EA  E  NK  + 
Sbjct: 1595 IKQV------------RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642

Query: 190  EYERARR---EALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLK 246
              ++ R+   +  +  +  EE R   D++ A++   +  E KLK +EA  L+ ++E    
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQS---KESEKKLKSLEAEILQLQEELASS 1699

Query: 247  QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
            +R      E+ER ++      +  G+        +L  R  Q++EELE ++  ++ L ++
Sbjct: 1700 ERAR-RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758

Query: 307  ------EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAK----- 355
                  + ++    LA            +Q +E Q +  +A+  EL+  ++ + K     
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818

Query: 356  ------EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLI 409
                  ++ E+ E E A+ER+A ++L+        ++ ++K+++     E+  +H +Q  
Sbjct: 1819 LEAKIGQLEEQLEQE-AKERAAANKLV--------RRTEKKLKEIFMQVEDERRHADQYK 1869

Query: 410  RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
              +E+      R K+   +L+ A ++   A  + R+LQ  E D   E  E  +R V  L 
Sbjct: 1870 EQMEKAN---ARMKQLKRQLEEAEEEATRANASRRKLQR-ELDDATEANEGLSREVSTLK 1925

Query: 470  DAL 472
            + L
Sbjct: 1926 NRL 1928



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 110/531 (20%), Positives = 227/531 (42%), Gaps = 98/531 (18%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ-REKM 72
            +R +QQL    E++  L +Q +  +  F  ++   ++ A  + K   +  +H  + R + 
Sbjct: 879  ERKHQQLL---EEKNILAEQLQAETELFAEAEEMRARLA--AKKQELEEILHDLESRVEE 933

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARE---LEELRLSMNLQERRIREQHGKLKSAKEE 129
            +EE+ + L+  ++K++  +Q+ ++ L  E    ++L+L     E +I++   ++   +++
Sbjct: 934  EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993

Query: 130  QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYEN 189
              K I E+ L E       ++ E    L ++    +  + K   KQ+   ++ E +  + 
Sbjct: 994  NSKFIKEKKLMED------RIAECSSQLAEEEE-KAKNLAKIRNKQEVMISDLEERLKKE 1046

Query: 190  EYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLK------EVEATKLKKEQEN 243
            E  R   E  +R K + E   L+D  Q   L  Q++ELKL+      E++    + + E 
Sbjct: 1047 EKTRQELEKAKR-KLDGETTDLQD--QIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103

Query: 244  LLKQ---------RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
            L K          + ++  L+E+ +  +A R KAE              ++ + + EELE
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAE--------------KQKRDLSEELE 1149

Query: 295  ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL------------------ 336
            A +  L+  L+     Q L   +REQ   +VA +K+A+EE+                   
Sbjct: 1150 ALKTELEDTLDTTAAQQELR-TKREQ---EVAELKKALEEETKNHEAQIQDMRQRHATAL 1205

Query: 337  -----QLERAREAELQMLLREEAKEMWEKR---EAEWARERSARDRLMSEVLTGRQQQIQ 388
                 QLE+A+  +  +   ++  E   K    E +  ++  A      + L  + Q++ 
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265

Query: 389  EKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL------------------- 429
             K+ +  R + E  +   +L   L+ V  L    +++  K                    
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325

Query: 430  -KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAET 479
             ++ +K  L +++ +   +     +Q+EEEEE  + +E+   AL  Q A+T
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 92/384 (23%), Positives = 174/384 (45%), Gaps = 37/384 (9%)

Query: 107  LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSW 166
            L +  QE  ++ +  +L   KE+Q K+  E  L E  +K+   L E  +   Q       
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGE--LEEMERKHQQLLEEKNILAEQLQAETEL 902

Query: 167  EMQKEEKKQQEATAEQE--------NKRYENEYERARREALERMKAEEERRQLEDKLQAE 218
              + EE + + A  +QE          R E E ER +    E+ K +   + LE++L  E
Sbjct: 903  FAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962

Query: 219  ALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQY 278
               +Q  +L+    EA K+KK +E +L    +  +  +E+K ME   + AE    L  + 
Sbjct: 963  EGARQKLQLEKVTAEA-KIKKMEEEILLLEDQNSKFIKEKKLME--DRIAECSSQLAEE- 1018

Query: 279  NAQLSRRTQQIQEELEADRRILQALLEKEDES-QRLHLARREQVMADVAWMKQAIEEQLQ 337
              + ++   +I+ + E     L+  L+KE+++ Q L  A+R+          Q  E Q Q
Sbjct: 1019 -EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077

Query: 338  LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
            ++   E +LQ+  +EE  +    R  +    ++   +++ E L  +  ++QE  E  + +
Sbjct: 1078 ID---ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE-LQAQIAELQEDFESEKAS 1133

Query: 398  QEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKSARKQEL---EAQ 440
            + ++ K +  L   LE ++              EL  + ++E  +LK A ++E    EAQ
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193

Query: 441  VAERRLQAWEADQQEEEEEEEARR 464
            + + R +   A ++  E+ E+A+R
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKR 1217



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 98/415 (23%), Positives = 184/415 (44%), Gaps = 58/415 (13%)

Query: 75   EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
            E  ++   + EK ++ + EE + L  ELE+  L     ++ +R         K EQ    
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDT-LDTTAAQQELR--------TKREQEVAE 1178

Query: 135  AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEM--QKEEKKQQEATAEQENKRYENEYE 192
             ++ L E  K +  +++    D+ Q+H     E+  Q E+ K+ +A  E+  +  E + +
Sbjct: 1179 LKKALEEETKNHEAQIQ----DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234

Query: 193  RARREA--LERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE-QENLLKQRW 249
                E   L+++KAE E ++   KL A     Q++EL  K  E  +L+ E  E   K + 
Sbjct: 1235 ELACEVKVLQQVKAESEHKR--KKLDA-----QVQELHAKVSEGDRLRVELAEKASKLQN 1287

Query: 250  ELERL-----EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALL 304
            EL+ +     E E+K ++  +  A L         +QL    + +QEE      +   + 
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASL--------ESQLQDTQELLQEETRQKLNLSSRIR 1339

Query: 305  EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKR--- 361
            + E+E   L   + E+  A     KQ +  Q QL   ++     L   E+ E  +K+   
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 362  EAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE-------- 413
            +AE   +R     L  + L   + ++Q++++         L H+ Q+  NLE        
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDD----LTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 414  ---EVRELARREKEESEKLKS-ARKQELEAQVAERRL-QAWEADQQEEEEEEEAR 463
               E + ++ R  EE ++ ++ AR++E +A    R L +A EA ++ E + ++ R
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 72/275 (26%), Positives = 145/275 (52%), Gaps = 35/275 (12%)

Query: 222  QQMEELKLKEVEATKLKKEQENLLKQRWELERLEE------ERKQMEAFRQKAELGRFLR 275
            +Q EEL+ K+ E  K+K++Q    K   ELE +E       E K + A + +AE   F  
Sbjct: 849  RQEEELQAKDEELLKVKEKQT---KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 276  -HQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEE 334
              +  A+L+ + Q+++E L      L++ +E+E+E  ++    ++++ A +  +++ ++E
Sbjct: 906  AEEMRARLAAKKQELEEILHD----LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961

Query: 335  Q------LQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQ 388
            +      LQLE+   AE ++   EE   + E + +++ +E+    +LM + +     Q+ 
Sbjct: 962  EEGARQKLQLEKV-TAEAKIKKMEEEILLLEDQNSKFIKEK----KLMEDRIAECSSQLA 1016

Query: 389  EKIEQNRRAQEESLKHREQLIRNLEE---VRELARREKEESEKLKSARKQELEAQVAERR 445
            E+ E+ +   +   K +E +I +LEE     E  R+E E++++       +L+ Q+AE  
Sbjct: 1017 EEEEKAKNLAKIRNK-QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE-- 1073

Query: 446  LQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM 480
            LQA    Q +E + + A++ E+L  AL + + ET+
Sbjct: 1074 LQA----QIDELKLQLAKKEEELQGALARGDDETL 1104



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 103/409 (25%), Positives = 170/409 (41%), Gaps = 71/409 (17%)

Query: 111  LQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWK------KNNPKLR--EMELDLHQKHV 162
            L  +   ++  +L + K  QR   A  L   HW+      K  P L+    E +L  K  
Sbjct: 801  LARKAFAKKQQQLSALKVLQRNCAA-YLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDE 859

Query: 163  VNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQ 222
                E+ K ++KQ +   E E      E ER  ++ LE      E+ Q E +L AEA   
Sbjct: 860  ----ELLKVKEKQTKVEGELE------EMERKHQQLLEEKNILAEQLQAETELFAEA--- 906

Query: 223  QMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQL 282
              EE++ +       K+E E +L         EEER Q+    +K             ++
Sbjct: 907  --EEMRAR---LAAKKQELEEILHDLESRVEEEEERNQILQNEKK-------------KM 948

Query: 283  SRRTQQIQEELEADRRILQAL-LEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERA 341
                Q ++E+L+ +    Q L LEK     ++     E ++ +    K   E++L  +R 
Sbjct: 949  QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008

Query: 342  REAELQMLLREE-AKEMWEKREAEWARERSARDRLMSE------------VLTGRQQQIQ 388
             E   Q+   EE AK + + R  +        +RL  E             L G    +Q
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 389  EKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARK--QELEAQVAE--- 443
            ++I +  +AQ + LK   QL +  EE++    R  +E+    +A K  +EL+AQ+AE   
Sbjct: 1069 DQIAE-LQAQIDELK--LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 444  ----RRLQAWEADQQEEEEEEEARRVE-QLSDAL----LQQEAETMAEQ 483
                 +    +A++Q+ +  EE   ++ +L D L     QQE  T  EQ
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score =  102 bits (253), Expect = 1e-21
 Identities = 120/500 (24%), Positives = 227/500 (45%), Gaps = 96/500 (19%)

Query: 12  SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
           SQ  + Q     R+  +RL   W+               +   S+  + ++    Y  E 
Sbjct: 137 SQHAVKQLEGEARDLISRLHDSWK----------FAGELEQALSAVATQKKKADRYIEEL 186

Query: 72  MKEEKRRSLEARR-----EKLRQL---MQEEQDLLARELEELRLSMNLQERRIREQHGKL 123
            KE    SLE  R     E+L++    +QE+  L+  E  E++L+       ++E   KL
Sbjct: 187 TKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-------VKELKRKL 239

Query: 124 KSAK----EEQRKLIAEQL---LYEHWKKNNPKLREMEL--DLHQKHVVNSWEMQKEEKK 174
           + AK    ++Q +  A+ L   L     K   ++ E EL   L+Q+     W  +++ ++
Sbjct: 240 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299

Query: 175 QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEA 234
           ++E   EQE K  E E +  R+E +   K E+ RRQ E   + E  ++++EE   K  E 
Sbjct: 300 REEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE---KMHEQ 356

Query: 235 TKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE 294
            K+++++E    +R E E++ E+ K               R +  A++ R+ ++I+E+ E
Sbjct: 357 EKIREQEE----KRQEEEKIREQEK---------------RQEQEAKMWRQEEKIREQEE 397

Query: 295 ADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEA 354
             R   + + E+E++                           Q E+  E E +M  +EE 
Sbjct: 398 KIREQEEMMQEQEEKMGE------------------------QEEKMWEQEEEMQEQEEK 433

Query: 355 KEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKI----EQNRRAQEESLKHREQ--- 407
                +R+ E  RE+  + R   E +  +++ +QE+     EQ  +  E+  K +EQ   
Sbjct: 434 M----RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489

Query: 408 LIRNLEEVRELARREKEESEKLKSARK--QELEAQVAERRLQAWEADQQEEEEEEEARRV 465
           + R  E++RE  ++ +E+ EK++   +  QE E ++ E+  +  E +++ +E+EE+ RR 
Sbjct: 490 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 549

Query: 466 EQL---SDALLQQEAETMAE 482
           E+     +  L+Q+ E M E
Sbjct: 550 EEKMREQEVRLRQQEEKMQE 569



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 110/435 (25%), Positives = 210/435 (48%), Gaps = 52/435 (11%)

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
           Q++ H +Q     E  RR LEA+ + +R        +L  +  EL++++   +  +++  
Sbjct: 99  QKASHQHQ-----EALRRELEAQVQTIR--------ILTCQKTELQMALYYSQHAVKQLE 145

Query: 121 GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           G       E R LI+   L++ WK           +L Q     + + +K ++  +E T 
Sbjct: 146 G-------EARDLISR--LHDSWKFAG--------ELEQALSAVATQKKKADRYIEELTK 188

Query: 181 EQENKRYENEYERARREALERMKAE-EERRQLEDKLQAEALLQQMEELKLKEVEATKLKK 239
           E++    E        E L+   A+ +E+ QL +  ++E  L  ++ELK K +E  KL  
Sbjct: 189 ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLN-VKELKRK-LERAKLLL 246

Query: 240 EQENLLKQRWEL-ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRR 298
            Q+ L  +   L + L+    +++A  ++ EL   L  Q   ++ R+ ++IQE  E  + 
Sbjct: 247 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQE 306

Query: 299 ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL--QLERAREAELQMLLREEAKE 356
             + + E+E++     + R+E++M +     +  EE +  + E+ RE E +M  +E+ +E
Sbjct: 307 QEEKIREQEEK-----MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 361

Query: 357 MWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE-V 415
             EKR+ E  + R    R   E    RQ++   + E+  R QEE ++ +E+ +   EE +
Sbjct: 362 QEEKRQEE-EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420

Query: 416 RELARREKEESEKLK----SARKQELEAQVAERRLQAWEADQQEEEE---EEEARRVEQL 468
            E     +E+ EK++      R+QE + +  E +++  E   QE+EE   E+E +  EQ 
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ- 479

Query: 469 SDALLQQEAETMAEQ 483
            +A +Q++ E M  Q
Sbjct: 480 -EAKMQEQEEKMRRQ 493



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 89/385 (23%), Positives = 167/385 (43%), Gaps = 51/385 (13%)

Query: 123 LKSAKEEQRKLI-AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAE 181
           + S +  Q KL  A++ L +H  + NP +     D  +K + N    +        +  E
Sbjct: 38  MMSKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSP-E 96

Query: 182 QENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQ 241
            E K      E  RRE   +++        + +LQ  AL      +K  E EA  L    
Sbjct: 97  DEQKASHQHQEALRRELEAQVQTIRILTCQKTELQM-ALYYSQHAVKQLEGEARDLISR- 154

Query: 242 ENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
              L   W+    LE+    +   ++KA+       +Y  +L++    +  EL  +    
Sbjct: 155 ---LHDSWKFAGELEQALSAVATQKKKAD-------RYIEELTKERDALSLELYRNTITD 204

Query: 301 QALLEKEDESQ-RLHLARRE--QVMADVAWMKQAIE--------EQLQLE------RARE 343
           + L EK  + Q +L L   E  ++  +V  +K+ +E        +QLQ E        + 
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264

Query: 344 AELQMLLREEAKEMW-----EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQ 398
              ++  + E  E+W     ++ E  W +E   ++R         +++IQE+ E+  R Q
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER---------EEKIQEQ-EEKIREQ 314

Query: 399 EESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEE 458
           EE ++ +E+++   EE  ++ R+E+   EK +  R+ E +    E+  +  E  Q+EE+ 
Sbjct: 315 EEKMRRQEEMMWEKEE--KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372

Query: 459 EEEARRVEQLSDALLQQEAETMAEQ 483
            E+ +R EQ  +A + ++ E + EQ
Sbjct: 373 REQEKRQEQ--EAKMWRQEEKIREQ 395


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 101/429 (23%), Positives = 203/429 (47%), Gaps = 48/429 (11%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
           K AE   K     S  +  +  +K+ KR+   A+    +Q +Q E D L +EL+ +  S 
Sbjct: 219 KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV--SA 276

Query: 110 NLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQ 169
            LQ +    +   L + ++E++    E+ + E       K+ E EL + ++     W  +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQ----EEKMCEQELKIREQEE-KMWRQE 331

Query: 170 KEEKKQQEATAEQENKRYENE-----YERARREALERMKAEEER-RQLEDKLQAEALLQQ 223
           ++  +Q+E   EQE+K +  E      E   RE  E+M  +EE+ R+ ++K+Q +     
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391

Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
            +E K++E E  + +K      K R + E++ E+ ++M  +RQ+ ++             
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKI------------- 436

Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
           R  +++ ++ E   R ++  +++E+E  +    + E++        Q  EE++Q +  + 
Sbjct: 437 RELEEMMQDQEEKLREVEEKMQEEEEKMQ---EQEEKI--------QRQEEKIQEQEEKT 485

Query: 344 AELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
              + LL++E K +WE+ E  W +E     ++  M E     Q+Q ++  EQ  R  ++ 
Sbjct: 486 WRQEKLLKQEEK-IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544

Query: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
            K +EQ +R L+E+ E   +  +++E L  A ++        +RL       Q E + +E
Sbjct: 545 EKMQEQEVR-LQELEERLGKLGQKAELLGGAGRES-----GSQRLPTLTPILQVELKSQE 598

Query: 462 ARRVEQLSD 470
           A+ ++Q  D
Sbjct: 599 AQSLQQQQD 607



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 94/344 (27%), Positives = 171/344 (49%), Gaps = 34/344 (9%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEW--SSKTSYQR 62
           W  ++++ +Q  +  EQE ++R+Q    W Q  +     + I   +   W    K   Q 
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQE 359

Query: 63  SMHAYQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
                Q EKM  +EEK R  + + ++  + M  +++ +  + E+ +  M  QE+++REQ 
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419

Query: 121 GKLKSAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--- 174
            K++  +EE   Q + I E  L E  +    KLRE+E  + ++      +MQ++E+K   
Sbjct: 420 EKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLREVEEKMQEEEE----KMQEQEEKIQR 473

Query: 175 QQEATAEQENKRYENEYERARREAL----ERMKAEEERR-QLEDKLQAEALLQQMEELKL 229
           Q+E   EQE K +  E    + E +    E+M  +EE+  + E+K+Q +    Q +E K+
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKM 533

Query: 230 KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAE-LGRFLRHQYNAQLSRRTQQ 288
           +E E  +L +++E + +Q   L+ LEE   ++    QKAE LG   R   + +L   T  
Sbjct: 534 REQE-VRLWQQEEKMQEQEVRLQELEE---RLGKLGQKAELLGGAGRESGSQRLPTLTPI 589

Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAI 332
           +Q EL++     Q+L +++D   R HL +       +A  K+A+
Sbjct: 590 LQVELKSQE--AQSLQQQQDH-YRGHLQQYVAAYQQLASGKEAL 630



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 113/490 (23%), Positives = 227/490 (46%), Gaps = 82/490 (16%)

Query: 22  RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHA-----YQREKMKEEK 76
           +  E+    R++      + R+ ++ + K+ E S         HA     Y  +  KE  
Sbjct: 141 KMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERD 200

Query: 77  RRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
             SLE  R  +    +E ++  A   E+LRL +  ++  I+     LK   E  + L+ +
Sbjct: 201 APSLELYRNTITD--EELKEKNAELQEKLRL-VESEKSEIQLNVKDLKRKLERAQLLLPQ 257

Query: 137 QLLYEHWKKNNPKLR----EMELDLHQKHVVNSWEMQKEEK--KQQEATAEQENKRYENE 190
           Q L     +   +L+    +++  + +  + N    Q+EEK  +Q+E   EQE K  E E
Sbjct: 258 QQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQE 317

Query: 191 YERARREALERM-KAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRW 249
            +   RE  E+M + EE+  + E+K++ +      +E K++E E  K+++++E + +Q  
Sbjct: 318 LKI--REQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEE-KIREQEEKMWRQE- 373

Query: 250 ELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE 309
                E+ R+Q E  +++ E           ++ R+ ++I+E+               +E
Sbjct: 374 -----EKIREQDEKIQEQEE-----------EMWRQEEKIREQ---------------EE 402

Query: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE-AKEMWEKREAEWARE 368
            ++  + R+E+ M +            Q E+ RE E +M  +EE  +E+ E  + +  + 
Sbjct: 403 KRQEKMWRQEKKMRE------------QDEKIREQEEEMWRQEEKIRELEEMMQDQEEKL 450

Query: 369 RSARDRLMSEVLTGRQQQIQEKI---EQNRRAQEESLKHREQLIRNLEEVRELARR---- 421
           R   +++  E    + Q+ +EKI   E+  + QEE    +E+L++  E++ E   +    
Sbjct: 451 REVEEKMQEE--EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508

Query: 422 -----EKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDAL--LQ 474
                E+EE  + +  + Q  E ++ E+ ++ W   QQEE+ +E+  R+++L + L  L 
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW---QQEEKMQEQEVRLQELEERLGKLG 565

Query: 475 QEAETMAEQG 484
           Q+AE +   G
Sbjct: 566 QKAELLGGAG 575



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 96/452 (21%), Positives = 219/452 (48%), Gaps = 58/452 (12%)

Query: 70  EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
           +K  +E + S + R+EK+ +     +  +  +   LRL             G++ + K  
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRL-------------GEVTAQKRP 171

Query: 130 QRKLIAEQLLYEHWKKNNPKLREM-------ELDLHQKHVVNSWEMQKEEKKQQEATAEQ 182
           +  L+ E L ++H  +    + ++        L+L++  + +  E++++  + QE     
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDE-ELKEKNAELQEKLRLV 230

Query: 183 ENKRYE---------NEYERAR------REALERMKAEEERRQLEDKLQAEA-------L 220
           E+++ E          + ERA+      +  +E  +  +E + +  KLQA+        L
Sbjct: 231 ESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNL 290

Query: 221 LQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNA 280
           L Q +E K+   E  K+++++E + +Q  EL+  E+E K      +  E    +R Q + 
Sbjct: 291 LNQQQEEKMWRQEE-KIQEQEEKMCEQ--ELKIREQEEKMWRQEEKMHEQEEKIREQED- 346

Query: 281 QLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAW-MKQAIEEQLQLE 339
           ++ R+ ++I+E+ E  R   + +  +E++ +      +EQ   +  W  ++ I EQ +  
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ--EEEMWRQEEKIREQEEKR 404

Query: 340 RAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQE 399
           + +    +  +RE+ +++ E+ E  W +E   R+  + E++  ++++++E +E+  + +E
Sbjct: 405 QEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLRE-VEEKMQEEE 461

Query: 400 ESLKHREQLIRNLEE-VRELARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEE 457
           E ++ +E+ I+  EE ++E   +   + + LK   K  E E ++  +  + WE +++ +E
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQE 521

Query: 458 EEEEARRVEQL---SDALLQQEAETMAEQGYR 486
           +EE+ +R E+     +  L Q+ E M EQ  R
Sbjct: 522 QEEKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 75/382 (19%), Positives = 174/382 (45%), Gaps = 60/382 (15%)

Query: 152 EMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQEN----KRYENEYERARREALERM 202
           + +LD H    +N  E Q + +     K +E +   E        E   E  +R   +R 
Sbjct: 29  DSDLDFH----INKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRW 84

Query: 203 KAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQRWELERLEEE 257
             +++  + ED  Q +  L+++     ++  +++   + +KK  + + K  ++ +R E+ 
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEV-KSSFK-KRQEKM 142

Query: 258 RKQMEAFRQKAELGR-FLR-HQYNAQLSRRTQQIQEELEADRRILQAL----LEKEDESQ 311
            ++   FR++  + + +LR  +  AQ       ++E L  D  +        L KE ++ 
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAP 202

Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR------EEAKEMWEKREAEW 365
            L L R      ++      ++E+L+L  + ++E+Q+ ++      E A+ +  +++ + 
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262

Query: 366 ARERSARD------RLMSEVLTGR------QQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
             +R  ++      +L ++V          QQQ ++   Q  + QE+  K  EQ ++  E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322

Query: 414 EVRELARREK---EESEKLK---------SARKQELEAQVAERRLQAWEADQQEEEEEEE 461
           +  ++ R+E+   E+ EK++           + +E E ++ E+  + W   +QEE+  E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMW---RQEEKIREQ 379

Query: 462 ARRVEQLSDALLQQEAETMAEQ 483
             ++++  + + +QE E + EQ
Sbjct: 380 DEKIQEQEEEMWRQE-EKIREQ 400


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 101/429 (23%), Positives = 203/429 (47%), Gaps = 48/429 (11%)

Query: 50  KQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSM 109
           K AE   K     S  +  +  +K+ KR+   A+    +Q +Q E D L +EL+ +  S 
Sbjct: 219 KNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSV--SA 276

Query: 110 NLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQ 169
            LQ +    +   L + ++E++    E+ + E       K+ E EL + ++     W  +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQ----EEKMCEQELKIREQEE-KMWRQE 331

Query: 170 KEEKKQQEATAEQENKRYENE-----YERARREALERMKAEEER-RQLEDKLQAEALLQQ 223
           ++  +Q+E   EQE+K +  E      E   RE  E+M  +EE+ R+ ++K+Q +     
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391

Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
            +E K++E E  + +K      K R + E++ E+ ++M  +RQ+ ++             
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKI------------- 436

Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
           R  +++ ++ E   R ++  +++E+E  +    + E++        Q  EE++Q +  + 
Sbjct: 437 RELEEMMQDQEEKLREVEEKMQEEEEKMQ---EQEEKI--------QRQEEKIQEQEEKT 485

Query: 344 AELQMLLREEAKEMWEKREAEWARERS--ARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
              + LL++E K +WE+ E  W +E     ++  M E     Q+Q ++  EQ  R  ++ 
Sbjct: 486 WRQEKLLKQEEK-IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544

Query: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
            K +EQ +R L+E+ E   +  +++E L  A ++        +RL       Q E + +E
Sbjct: 545 EKMQEQEVR-LQELEERLGKLGQKAELLGGAGRES-----GSQRLPTLTPILQVELKSQE 598

Query: 462 ARRVEQLSD 470
           A+ ++Q  D
Sbjct: 599 AQSLQQQQD 607



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 94/344 (27%), Positives = 171/344 (49%), Gaps = 34/344 (9%)

Query: 10  WCSQQRLNQQLARQREQEARLRQQ----WEQNSRYFRMSD-ICSSKQAEW--SSKTSYQR 62
           W  ++++ +Q  +  EQE ++R+Q    W Q  +     + I   +   W    K   Q 
Sbjct: 300 WRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQE 359

Query: 63  SMHAYQREKM--KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH 120
                Q EKM  +EEK R  + + ++  + M  +++ +  + E+ +  M  QE+++REQ 
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419

Query: 121 GKLKSAKEE---QRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKK--- 174
            K++  +EE   Q + I E  L E  +    KLRE+E  + ++      +MQ++E+K   
Sbjct: 420 EKIREQEEEMWRQEEKIRE--LEEMMQDQEEKLREVEEKMQEEEE----KMQEQEEKIQR 473

Query: 175 QQEATAEQENKRYENEYERARREAL----ERMKAEEERR-QLEDKLQAEALLQQMEELKL 229
           Q+E   EQE K +  E    + E +    E+M  +EE+  + E+K+Q +    Q +E K+
Sbjct: 474 QEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKM 533

Query: 230 KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAE-LGRFLRHQYNAQLSRRTQQ 288
           +E E  +L +++E + +Q   L+ LEE   ++    QKAE LG   R   + +L   T  
Sbjct: 534 REQE-VRLWQQEEKMQEQEVRLQELEE---RLGKLGQKAELLGGAGRESGSQRLPTLTPI 589

Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAI 332
           +Q EL++     Q+L +++D   R HL +       +A  K+A+
Sbjct: 590 LQVELKSQE--AQSLQQQQDH-YRGHLQQYVAAYQQLASGKEAL 630



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 90/390 (23%), Positives = 193/390 (49%), Gaps = 48/390 (12%)

Query: 107 LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVV 163
           LS+ L    I ++  K K+A+ +++  + E    E   + K    KL   +L L Q+ + 
Sbjct: 202 LSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQL- 260

Query: 164 NSWEMQKEEKKQQEATAEQENKRYENE-YERARREALERMKAEEERRQLEDKLQAEALLQ 222
              E  +  K+ Q  +A+ + +  ENE +    ++  E+M  +EE+ Q +++   E  L+
Sbjct: 261 -QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELK 319

Query: 223 QMEELKLKEVEATKLKKEQENLLKQRWELERLEEE-RKQMEAFRQKAELGRFLRHQYNAQ 281
             E+ +    +  K+ +++E + +Q  ++ R EE+ R+Q E  R++ E           +
Sbjct: 320 IREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE-----------K 368

Query: 282 LSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERA 341
           + R+ ++I+E+ E        + E+E+E  R     REQ        ++  +E++  +  
Sbjct: 369 MWRQEEKIREQDEK-------IQEQEEEMWRQEEKIREQ--------EEKRQEKMWRQEK 413

Query: 342 REAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
           +  E    +RE+ +EMW + E         + R + E++  ++++++E +E+  + +EE 
Sbjct: 414 KMREQDEKIREQEEEMWRQEE---------KIRELEEMMQDQEEKLRE-VEEKMQEEEEK 463

Query: 402 LKHREQLIRNLEE-VRELARREKEESEKLKSARK-QELEAQVAERRLQAWEADQQEEEEE 459
           ++ +E+ I+  EE ++E   +   + + LK   K  E E ++  +  + WE +++ +E+E
Sbjct: 464 MQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523

Query: 460 EEARRVEQL---SDALLQQEAETMAEQGYR 486
           E+ +R E+     +  L Q+ E M EQ  R
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVR 553



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 96/439 (21%), Positives = 203/439 (46%), Gaps = 66/439 (15%)

Query: 70  EKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEE 129
           +K  +E + S + R+EK+ +     +  +  +   LRL             G++ + K  
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRL-------------GEVTAQKRP 171

Query: 130 QRKLIAEQLLYEHWKKNNPKLREM-------ELDLHQKHVVNSWEMQKEEKKQQEATAEQ 182
           +  L+ E L ++H  +    + ++        L+L++  + +      EE K++ A  ++
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITD------EELKEKNAELQE 225

Query: 183 ENKRYENEYERARREALERMKAEEERRQL---EDKLQAEA--LLQQMEELKLKEVEATKL 237
           + +  E+E    +    + +K + ER QL   + +LQ EA  L ++++ +  K ++A   
Sbjct: 226 KLRLVESEKSEIQLNVKD-LKRKLERAQLLLPQQQLQVEADRLGKELQSVSAK-LQAQVE 283

Query: 238 KKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR 297
           + E  NLL Q+ E +   +E K  E   +  E    +R Q   ++ R+ +++ E+ E  R
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQ-EEKMWRQEEKMHEQEEKIR 342

Query: 298 RILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM 357
                +  +E++ +      REQ            EE++  +  +  E    ++E+ +EM
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQ------------EEKMWRQEEKIREQDEKIQEQEEEM 390

Query: 358 WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE--- 414
           W + E    +E   ++++       RQ++   + ++  R QEE +  +E+ IR LEE   
Sbjct: 391 WRQEEKIREQEEKRQEKMW------RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444

Query: 415 -----VRELARREKEESEKLKSARK--QELEAQVAERRLQAWEAD---QQEEEEEEEARR 464
                +RE+  + +EE EK++   +  Q  E ++ E+  + W  +   +QEE+  E+  +
Sbjct: 445 DQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504

Query: 465 VEQLSDALLQQEAETMAEQ 483
           + +  + + +QE E M EQ
Sbjct: 505 MWRQEEKMWEQE-EKMQEQ 522



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 75/382 (19%), Positives = 174/382 (45%), Gaps = 60/382 (15%)

Query: 152 EMELDLHQKHVVNSWEMQKEEK-----KQQEATAEQEN----KRYENEYERARREALERM 202
           + +LD H    +N  E Q + +     K +E +   E        E   E  +R   +R 
Sbjct: 29  DSDLDFH----INKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTKRW 84

Query: 203 KAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQRWELERLEEE 257
             +++  + ED  Q +  L+++     ++  +++   + +KK  + + K  ++ +R E+ 
Sbjct: 85  DEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEV-KSSFK-KRQEKM 142

Query: 258 RKQMEAFRQKAELGR-FLR-HQYNAQLSRRTQQIQEELEADRRILQAL----LEKEDESQ 311
            ++   FR++  + + +LR  +  AQ       ++E L  D  +        L KE ++ 
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAL 202

Query: 312 RLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR------EEAKEMWEKREAEW 365
            L L R      ++      ++E+L+L  + ++E+Q+ ++      E A+ +  +++ + 
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262

Query: 366 ARERSARD------RLMSEVLTGR------QQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
             +R  ++      +L ++V          QQQ ++   Q  + QE+  K  EQ ++  E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322

Query: 414 EVRELARREK---EESEKLK---------SARKQELEAQVAERRLQAWEADQQEEEEEEE 461
           +  ++ R+E+   E+ EK++           + +E E ++ E+  + W   +QEE+  E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMW---RQEEKIREQ 379

Query: 462 ARRVEQLSDALLQQEAETMAEQ 483
             ++++  + + +QE E + EQ
Sbjct: 380 DEKIQEQEEEMWRQE-EKIREQ 400


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)

Query: 20   LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            LAR  E+    +++ E+ ++  +  M D+ SSK           +++H  ++ K      
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1534

Query: 78   RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
            R+LE + E+++  ++E E +L A E  +LRL +N+Q   ++ Q  +   A++EQ      
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1586

Query: 137  QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
                     N  K R+++  LH+      +E + E++++Q A A    K+ E + +    
Sbjct: 1587 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 197  EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
            +A   +K  EE  +   KLQA+     +++E+ +    E     KE E   K    +L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
            L+E+    E  R++A+L +              +++ EEL +      AL   +DE +RL
Sbjct: 1692 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1734

Query: 314  HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
              AR  Q           +EE+L+ E+     +   +R+ A +  E+   E A ERS   
Sbjct: 1735 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1781

Query: 374  RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
            +  S  + L  + ++++ K+ +   A +   K      E  I  LEE  E   REK+   
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            +S K K  + +E+  QV + R     A+Q +E+ E+   RV+QL   L + E E+     
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 485  YRPK 488
             R K
Sbjct: 1899 NRRK 1902



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)

Query: 13   QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
            QQ+L      QR   A L+    Q W   ++   +  +   ++   + +   Q++    Q
Sbjct: 810  QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 869

Query: 69   RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
            +     K  E+K   L   +  L++ +Q E +L A E EE+R+ +  +++ + E   +++
Sbjct: 870  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 928

Query: 125  SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
            +  EE+     +QL  E       K+ +  LDL ++  +   E  +++ + ++ TAE + 
Sbjct: 929  ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 980

Query: 185  KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
            K+ E+E         +  K  +ER+ LE+++         EE K K +  TKLK + E++
Sbjct: 981  KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1035

Query: 245  LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
            + +    L++ E+ R+++E  ++K E      H+  A L  +  +++ +L      LQA 
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 304  LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
            L + D+     +A++   +  +  ++     ++E L  ERA   + +   R+  +E+   
Sbjct: 1096 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 358  -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
                          ++  A+  +E +   + + E     + Q+QE  +++ +A EE  + 
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 405  REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
             EQ  R   NL++ ++   +E  + + +L+   + + E +  +++L+A   + Q +  + 
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 461  EARRVEQLSDAL--LQQEAETM 480
            E  R E L+D +  LQ E E++
Sbjct: 1272 ERARAE-LNDKVHKLQNEVESV 1292



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)

Query: 15   RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
            RL+ ++A++     ++R+     S      D+ S + A   +K   Q+     + E +K 
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1153

Query: 75   EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            E   +L+  A +++LR   ++E  +L + L+E   S   Q + +R++H +   A EE   
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1207

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
             + EQL  E +K+    L + +  L +++   + E++   + +QE   E + K+ E + +
Sbjct: 1208 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1262

Query: 193  RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
              + +  +  +A  E      KLQ   E++   + E    E +A KL K+  +L  Q  +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1319

Query: 251  LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
             + L +E       RQK  +   LR Q   + +    Q+ EE+EA +      LE+   +
Sbjct: 1320 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1368

Query: 311  QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
              + L+  ++ + D A   +A+EE    ++  + E++ L ++     +E++ A + +   
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1420

Query: 371  ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
             ++RL  E     V    Q+Q+   +E+ +R  ++ L   + +     + R+ A  E  E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 426  SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
             E     L  A ++ LEA +  ER  +  +A+ ++    +++  + V +L  S   L+ +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 477  AETMAEQ 483
             E M  Q
Sbjct: 1541 MEEMKTQ 1547



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)

Query: 173  KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
            K+QQ+ TA +  +R    Y + R           +  L+  + EEE +  ED+LQ     
Sbjct: 808  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867

Query: 222  QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
            QQ  E +LKE+E    +  E++NLL+++ + E     E E  ++    +K EL   L H+
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 926

Query: 278  YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
              A+L     + Q+     +++ Q +L+ E++ +                 ++A  ++LQ
Sbjct: 927  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 970

Query: 338  LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
            LE+   AE ++   E+   + + +  + ++ER   +  +S++ T     + E+ E+ +  
Sbjct: 971  LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1025

Query: 398  QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
             +   KH E +I  LE   +   + ++E EKLK  RK E +A     Q+A+ + Q  E  
Sbjct: 1026 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1082

Query: 453  QQEEEEEEEAR-RVEQLSDALLQQ 475
             Q  ++EEE +  + +L D + Q+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQK 1106



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)

Query: 91   MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
            ++EE+DL   ++     +M    L  +   ++  +L + K  QR   A   L    W + 
Sbjct: 778  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 837

Query: 147  NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
              K++ +     Q+  + + E + ++ K+++  AE E K  E ++ +            E
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 887

Query: 207  ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
            E+  L+++LQAE  L               Q++EE+ L E+EA   ++E      Q    
Sbjct: 888  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 946

Query: 246  KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
            K   ++  LEE+ ++ EA RQK +L +               +    N +LS+  + ++E
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 292  ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
             +     +   L E+E++++ L                 L + E+   ++  +K+ +E  
Sbjct: 1007 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 334  -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
                 EQ+   +A+ AEL+M L    EE +    + + E A++ +A  ++    L G   
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1121

Query: 386  QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
             +QE ++  R A+ ++ K +  L   LE ++              EL  + ++E   LK 
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 432  ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            A  +E    EAQV E R +  +A ++  E+ E+ +R +    A L +  +T+ ++
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1232



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)

Query: 69   REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
            R  +++EKRR LEAR  +L + ++EEQ  +    + +R +    E+   E   +  +A++
Sbjct: 1724 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             +    A Q L    K+   KL EME  +  K             K   A  E +  + E
Sbjct: 1783 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1827

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             + E+   EA E+  A +  +Q + KL+ E LLQ  +E K+ E    + +K    + + +
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
             +LE  EEE +++ A R+K +       + N  + R    ++ +L
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)

Query: 20   LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            LAR  E+    +++ E+ ++  +  M D+ SSK           +++H  ++ K      
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1541

Query: 78   RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
            R+LE + E+++  ++E E +L A E  +LRL +N+Q   ++ Q  +   A++EQ      
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1593

Query: 137  QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
                     N  K R+++  LH+      +E + E++++Q A A    K+ E + +    
Sbjct: 1594 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 197  EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
            +A   +K  EE  +   KLQA+     +++E+ +    E     KE E   K    +L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
            L+E+    E  R++A+L +              +++ EEL +      AL   +DE +RL
Sbjct: 1699 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1741

Query: 314  HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
              AR  Q           +EE+L+ E+     +   +R+ A +  E+   E A ERS   
Sbjct: 1742 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1788

Query: 374  RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
            +  S  + L  + ++++ K+ +   A +   K      E  I  LEE  E   REK+   
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            +S K K  + +E+  QV + R     A+Q +E+ E+   RV+QL   L + E E+     
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 485  YRPK 488
             R K
Sbjct: 1906 NRRK 1909



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)

Query: 13   QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
            QQ+L      QR   A L+    Q W   ++   +  +   ++   + +   Q++    Q
Sbjct: 817  QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 876

Query: 69   RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
            +     K  E+K   L   +  L++ +Q E +L A E EE+R+ +  +++ + E   +++
Sbjct: 877  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 935

Query: 125  SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
            +  EE+     +QL  E       K+ +  LDL ++  +   E  +++ + ++ TAE + 
Sbjct: 936  ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 987

Query: 185  KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
            K+ E+E         +  K  +ER+ LE+++         EE K K +  TKLK + E++
Sbjct: 988  KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1042

Query: 245  LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
            + +    L++ E+ R+++E  ++K E      H+  A L  +  +++ +L      LQA 
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 304  LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
            L + D+     +A++   +  +  ++     ++E L  ERA   + +   R+  +E+   
Sbjct: 1103 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 358  -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
                          ++  A+  +E +   + + E     + Q+QE  +++ +A EE  + 
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 405  REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
             EQ  R   NL++ ++   +E  + + +L+   + + E +  +++L+A   + Q +  + 
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 461  EARRVEQLSDAL--LQQEAETM 480
            E  R E L+D +  LQ E E++
Sbjct: 1279 ERARAE-LNDKVHKLQNEVESV 1299



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)

Query: 15   RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
            RL+ ++A++     ++R+     S      D+ S + A   +K   Q+     + E +K 
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1160

Query: 75   EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            E   +L+  A +++LR   ++E  +L + L+E   S   Q + +R++H +   A EE   
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1214

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
             + EQL  E +K+    L + +  L +++   + E++   + +QE   E + K+ E + +
Sbjct: 1215 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1269

Query: 193  RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
              + +  +  +A  E      KLQ   E++   + E    E +A KL K+  +L  Q  +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1326

Query: 251  LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
             + L +E       RQK  +   LR Q   + +    Q+ EE+EA +      LE+   +
Sbjct: 1327 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1375

Query: 311  QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
              + L+  ++ + D A   +A+EE    ++  + E++ L ++     +E++ A + +   
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1427

Query: 371  ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
             ++RL  E     V    Q+Q+   +E+ +R  ++ L   + +     + R+ A  E  E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 426  SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
             E     L  A ++ LEA +  ER  +  +A+ ++    +++  + V +L  S   L+ +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 477  AETMAEQ 483
             E M  Q
Sbjct: 1548 MEEMKTQ 1554



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)

Query: 173  KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
            K+QQ+ TA +  +R    Y + R           +  L+  + EEE +  ED+LQ     
Sbjct: 815  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874

Query: 222  QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
            QQ  E +LKE+E    +  E++NLL+++ + E     E E  ++    +K EL   L H+
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 933

Query: 278  YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
              A+L     + Q+     +++ Q +L+ E++ +                 ++A  ++LQ
Sbjct: 934  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 977

Query: 338  LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
            LE+   AE ++   E+   + + +  + ++ER   +  +S++ T     + E+ E+ +  
Sbjct: 978  LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1032

Query: 398  QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
             +   KH E +I  LE   +   + ++E EKLK  RK E +A     Q+A+ + Q  E  
Sbjct: 1033 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1089

Query: 453  QQEEEEEEEAR-RVEQLSDALLQQ 475
             Q  ++EEE +  + +L D + Q+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQK 1113



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)

Query: 91   MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
            ++EE+DL   ++     +M    L  +   ++  +L + K  QR   A   L    W + 
Sbjct: 785  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 844

Query: 147  NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
              K++ +     Q+  + + E + ++ K+++  AE E K  E ++ +            E
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 894

Query: 207  ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
            E+  L+++LQAE  L               Q++EE+ L E+EA   ++E      Q    
Sbjct: 895  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 953

Query: 246  KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
            K   ++  LEE+ ++ EA RQK +L +               +    N +LS+  + ++E
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 292  ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
             +     +   L E+E++++ L                 L + E+   ++  +K+ +E  
Sbjct: 1014 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 334  -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
                 EQ+   +A+ AEL+M L    EE +    + + E A++ +A  ++    L G   
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1128

Query: 386  QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
             +QE ++  R A+ ++ K +  L   LE ++              EL  + ++E   LK 
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 432  ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            A  +E    EAQV E R +  +A ++  E+ E+ +R +    A L +  +T+ ++
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1239



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)

Query: 69   REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
            R  +++EKRR LEAR  +L + ++EEQ  +    + +R +    E+   E   +  +A++
Sbjct: 1731 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             +    A Q L    K+   KL EME  +  K             K   A  E +  + E
Sbjct: 1790 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1834

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             + E+   EA E+  A +  +Q + KL+ E LLQ  +E K+ E    + +K    + + +
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
             +LE  EEE +++ A R+K +       + N  + R    ++ +L
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)

Query: 20   LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            LAR  E+    +++ E+ ++  +  M D+ SSK           +++H  ++ K      
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1541

Query: 78   RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
            R+LE + E+++  ++E E +L A E  +LRL +N+Q   ++ Q  +   A++EQ      
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1593

Query: 137  QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
                     N  K R+++  LH+      +E + E++++Q A A    K+ E + +    
Sbjct: 1594 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 197  EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
            +A   +K  EE  +   KLQA+     +++E+ +    E     KE E   K    +L +
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
            L+E+    E  R++A+L +              +++ EEL +      AL   +DE +RL
Sbjct: 1699 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1741

Query: 314  HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
              AR  Q           +EE+L+ E+     +   +R+ A +  E+   E A ERS   
Sbjct: 1742 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1788

Query: 374  RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
            +  S  + L  + ++++ K+ +   A +   K      E  I  LEE  E   REK+   
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            +S K K  + +E+  QV + R     A+Q +E+ E+   RV+QL   L + E E+     
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 485  YRPK 488
             R K
Sbjct: 1906 NRRK 1909



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)

Query: 13   QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
            QQ+L      QR   A L+    Q W   ++   +  +   ++   + +   Q++    Q
Sbjct: 817  QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 876

Query: 69   RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
            +     K  E+K   L   +  L++ +Q E +L A E EE+R+ +  +++ + E   +++
Sbjct: 877  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 935

Query: 125  SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
            +  EE+     +QL  E       K+ +  LDL ++  +   E  +++ + ++ TAE + 
Sbjct: 936  ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 987

Query: 185  KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
            K+ E+E         +  K  +ER+ LE+++         EE K K +  TKLK + E++
Sbjct: 988  KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1042

Query: 245  LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
            + +    L++ E+ R+++E  ++K E      H+  A L  +  +++ +L      LQA 
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102

Query: 304  LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
            L + D+     +A++   +  +  ++     ++E L  ERA   + +   R+  +E+   
Sbjct: 1103 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158

Query: 358  -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
                          ++  A+  +E +   + + E     + Q+QE  +++ +A EE  + 
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 405  REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
             EQ  R   NL++ ++   +E  + + +L+   + + E +  +++L+A   + Q +  + 
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 461  EARRVEQLSDAL--LQQEAETM 480
            E  R E L+D +  LQ E E++
Sbjct: 1279 ERARAE-LNDKVHKLQNEVESV 1299



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)

Query: 15   RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
            RL+ ++A++     ++R+     S      D+ S + A   +K   Q+     + E +K 
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1160

Query: 75   EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            E   +L+  A +++LR   ++E  +L + L+E   S   Q + +R++H +   A EE   
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1214

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
             + EQL  E +K+    L + +  L +++   + E++   + +QE   E + K+ E + +
Sbjct: 1215 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1269

Query: 193  RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
              + +  +  +A  E      KLQ   E++   + E    E +A KL K+  +L  Q  +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1326

Query: 251  LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
             + L +E       RQK  +   LR Q   + +    Q+ EE+EA +      LE+   +
Sbjct: 1327 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1375

Query: 311  QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
              + L+  ++ + D A   +A+EE    ++  + E++ L ++     +E++ A + +   
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1427

Query: 371  ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
             ++RL  E     V    Q+Q+   +E+ +R  ++ L   + +     + R+ A  E  E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 426  SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
             E     L  A ++ LEA +  ER  +  +A+ ++    +++  + V +L  S   L+ +
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 477  AETMAEQ 483
             E M  Q
Sbjct: 1548 MEEMKTQ 1554



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)

Query: 173  KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
            K+QQ+ TA +  +R    Y + R           +  L+  + EEE +  ED+LQ     
Sbjct: 815  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874

Query: 222  QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
            QQ  E +LKE+E    +  E++NLL+++ + E     E E  ++    +K EL   L H+
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 933

Query: 278  YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
              A+L     + Q+     +++ Q +L+ E++ +                 ++A  ++LQ
Sbjct: 934  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 977

Query: 338  LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
            LE+   AE ++   E+   + + +  + ++ER   +  +S++ T     + E+ E+ +  
Sbjct: 978  LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1032

Query: 398  QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
             +   KH E +I  LE   +   + ++E EKLK  RK E +A     Q+A+ + Q  E  
Sbjct: 1033 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1089

Query: 453  QQEEEEEEEAR-RVEQLSDALLQQ 475
             Q  ++EEE +  + +L D + Q+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQK 1113



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)

Query: 91   MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
            ++EE+DL   ++     +M    L  +   ++  +L + K  QR   A   L    W + 
Sbjct: 785  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 844

Query: 147  NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
              K++ +     Q+  + + E + ++ K+++  AE E K  E ++ +            E
Sbjct: 845  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 894

Query: 207  ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
            E+  L+++LQAE  L               Q++EE+ L E+EA   ++E      Q    
Sbjct: 895  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 953

Query: 246  KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
            K   ++  LEE+ ++ EA RQK +L +               +    N +LS+  + ++E
Sbjct: 954  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013

Query: 292  ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
             +     +   L E+E++++ L                 L + E+   ++  +K+ +E  
Sbjct: 1014 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070

Query: 334  -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
                 EQ+   +A+ AEL+M L    EE +    + + E A++ +A  ++    L G   
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1128

Query: 386  QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
             +QE ++  R A+ ++ K +  L   LE ++              EL  + ++E   LK 
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 432  ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            A  +E    EAQV E R +  +A ++  E+ E+ +R +    A L +  +T+ ++
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1239



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)

Query: 69   REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
            R  +++EKRR LEAR  +L + ++EEQ  +    + +R +    E+   E   +  +A++
Sbjct: 1731 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             +    A Q L    K+   KL EME  +  K             K   A  E +  + E
Sbjct: 1790 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1834

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             + E+   EA E+  A +  +Q + KL+ E LLQ  +E K+ E    + +K    + + +
Sbjct: 1835 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
             +LE  EEE +++ A R+K +       + N  + R    ++ +L
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 121/484 (25%), Positives = 219/484 (45%), Gaps = 84/484 (17%)

Query: 20   LARQREQEARLRQQWEQNSRYFR--MSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            LAR  E+    +++ E+ ++  +  M D+ SSK           +++H  ++ K      
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------DVGKNVHELEKSK------ 1534

Query: 78   RSLEARREKLRQLMQE-EQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAE 136
            R+LE + E+++  ++E E +L A E  +LRL +N+Q   ++ Q  +   A++EQ      
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA--LKGQFERDLQARDEQ------ 1586

Query: 137  QLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARR 196
                     N  K R+++  LH+      +E + E++++Q A A    K+ E + +    
Sbjct: 1587 ---------NEEKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 197  EALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQENLLKQ-RWELER 253
            +A   +K  EE  +   KLQA+     +++E+ +    E     KE E   K    +L +
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691

Query: 254  LEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRL 313
            L+E+    E  R++A+L +              +++ EEL +      AL   +DE +RL
Sbjct: 1692 LQEDLAAAERARKQADLEK--------------EELAEELASSLSGRNAL---QDEKRRL 1734

Query: 314  HLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARD 373
              AR  Q           +EE+L+ E+     +   +R+ A +  E+   E A ERS   
Sbjct: 1735 E-ARIAQ-----------LEEELEEEQGNMEAMSDRVRK-ATQQAEQLSNELATERSTAQ 1781

Query: 374  RLMS--EVLTGRQQQIQEKIEQNRRAQEESLKHR----EQLIRNLEEVRELARREKE--- 424
            +  S  + L  + ++++ K+ +   A +   K      E  I  LEE  E   REK+   
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 425  ESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQG 484
            +S K K  + +E+  QV + R     A+Q +E+ E+   RV+QL   L + E E+     
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKM---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 485  YRPK 488
             R K
Sbjct: 1899 NRRK 1902



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 107/502 (21%), Positives = 232/502 (46%), Gaps = 53/502 (10%)

Query: 13   QQRLNQQLARQREQEARLR----QQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQ 68
            QQ+L      QR   A L+    Q W   ++   +  +   ++   + +   Q++    Q
Sbjct: 810  QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQ 869

Query: 69   RE----KMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLK 124
            +     K  E+K   L   +  L++ +Q E +L A E EE+R+ +  +++ + E   +++
Sbjct: 870  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEME 928

Query: 125  SAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQEN 184
            +  EE+     +QL  E       K+ +  LDL ++  +   E  +++ + ++ TAE + 
Sbjct: 929  ARLEEEEDR-GQQLQAE-----RKKMAQQMLDLEEQ--LEEEEAARQKLQLEKVTAEAKI 980

Query: 185  KRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENL 244
            K+ E+E         +  K  +ER+ LE+++         EE K K +  TKLK + E++
Sbjct: 981  KKLEDEILVMDD---QNNKLSKERKLLEERISDLTTNLAEEEEKAKNL--TKLKNKHESM 1035

Query: 245  LKQ-RWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
            + +    L++ E+ R+++E  ++K E      H+  A L  +  +++ +L      LQA 
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095

Query: 304  LEKEDESQRLHLARREQVMADVAWMK---QAIEEQLQLERAREAELQMLLREEAKEM--- 357
            L + D+     +A++   +  +  ++     ++E L  ERA   + +   R+  +E+   
Sbjct: 1096 LARLDD----EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 358  -------------WEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
                          ++  A+  +E +   + + E     + Q+QE  +++ +A EE  + 
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 405  REQLIR---NLEEVRELARREKEE-SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEE 460
             EQ  R   NL++ ++   +E  + + +L+   + + E +  +++L+A   + Q +  + 
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 461  EARRVEQLSDAL--LQQEAETM 480
            E  R E L+D +  LQ E E++
Sbjct: 1272 ERARAE-LNDKVHKLQNEVESV 1292



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 109/487 (22%), Positives = 223/487 (45%), Gaps = 55/487 (11%)

Query: 15   RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
            RL+ ++A++     ++R+     S      D+ S + A   +K   Q+     + E +K 
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDL--QEDLDSERAAR--NKAEKQKRDLGEELEALKT 1153

Query: 75   EKRRSLE--ARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRK 132
            E   +L+  A +++LR   ++E  +L + L+E   S   Q + +R++H +   A EE   
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ---AVEE--- 1207

Query: 133  LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
             + EQL  E +K+    L + +  L +++   + E++   + +QE   E + K+ E + +
Sbjct: 1208 -LTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE--VEHKKKKLEAQVQ 1262

Query: 193  RARREALERMKAEEERRQLEDKLQ--AEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
              + +  +  +A  E      KLQ   E++   + E    E +A KL K+  +L  Q  +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE---AEGKAIKLAKDVASLSSQLQD 1319

Query: 251  LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
             + L +E       RQK  +   LR Q   + +    Q+ EE+EA +      LE+   +
Sbjct: 1320 TQELLQEET-----RQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQN-----LERHIST 1368

Query: 311  QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
              + L+  ++ + D A   +A+EE    ++  + E++ L ++     +E++ A + +   
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEG---KKRFQKEIENLTQQ-----YEEKAAAYDKLEK 1420

Query: 371  ARDRLMSE-----VLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
             ++RL  E     V    Q+Q+   +E+ +R  ++ L   + +     + R+ A  E  E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 426  SE----KLKSARKQELEA-QVAERRLQAWEADQQE--EEEEEEARRVEQL--SDALLQQE 476
             E     L  A ++ LEA +  ER  +  +A+ ++    +++  + V +L  S   L+ +
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 477  AETMAEQ 483
             E M  Q
Sbjct: 1541 MEEMKTQ 1547



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 81/324 (25%), Positives = 154/324 (47%), Gaps = 46/324 (14%)

Query: 173  KKQQEATAEQENKRYENEYERAR-----------REALERMKAEEERRQLEDKLQAEALL 221
            K+QQ+ TA +  +R    Y + R           +  L+  + EEE +  ED+LQ     
Sbjct: 808  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867

Query: 222  QQMEELKLKEVEATKLK-KEQENLLKQRWELER---LEEERKQMEAFRQKAELGRFLRHQ 277
            QQ  E +LKE+E    +  E++NLL+++ + E     E E  ++    +K EL   L H+
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL-HE 926

Query: 278  YNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQ 337
              A+L     + Q+     +++ Q +L+ E++ +                 ++A  ++LQ
Sbjct: 927  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----------------EEAARQKLQ 970

Query: 338  LERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA 397
            LE+   AE ++   E+   + + +  + ++ER   +  +S++ T     + E+ E+ +  
Sbjct: 971  LEKV-TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT----NLAEEEEKAKNL 1025

Query: 398  QEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEA-----QVAERRLQAWEAD 452
             +   KH E +I  LE   +   + ++E EKLK  RK E +A     Q+A+ + Q  E  
Sbjct: 1026 TKLKNKH-ESMISELEVRLKKEEKSRQELEKLK--RKLEGDASDFHEQIADLQAQIAELK 1082

Query: 453  QQEEEEEEEAR-RVEQLSDALLQQ 475
             Q  ++EEE +  + +L D + Q+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQK 1106



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 104/475 (21%), Positives = 206/475 (43%), Gaps = 102/475 (21%)

Query: 91   MQEEQDLLARELEELRLSM---NLQERRIREQHGKLKSAKEEQRKLIAEQLLYE-HWKKN 146
            ++EE+DL   ++     +M    L  +   ++  +L + K  QR   A   L    W + 
Sbjct: 778  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRL 837

Query: 147  NPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEE 206
              K++ +     Q+  + + E + ++ K+++  AE E K  E ++ +            E
Sbjct: 838  FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT----------E 887

Query: 207  ERRQLEDKLQAEALL---------------QQMEELKLKEVEATKLKKE------QENLL 245
            E+  L+++LQAE  L               Q++EE+ L E+EA   ++E      Q    
Sbjct: 888  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERK 946

Query: 246  KQRWELERLEEERKQMEAFRQKAELGR--------------FLRHQYNAQLSRRTQQIQE 291
            K   ++  LEE+ ++ EA RQK +L +               +    N +LS+  + ++E
Sbjct: 947  KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006

Query: 292  ELEADRRILQALLEKEDESQRL----------------HLARREQVMADVAWMKQAIE-- 333
             +     +   L E+E++++ L                 L + E+   ++  +K+ +E  
Sbjct: 1007 RIS---DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063

Query: 334  -----EQLQLERAREAELQMLL---REEAKEMWEKREAEWARERSARDRLMSEVLTGRQQ 385
                 EQ+   +A+ AEL+M L    EE +    + + E A++ +A  ++    L G   
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE--LEGHIS 1121

Query: 386  QIQEKIEQNRRAQEESLKHREQLIRNLEEVR--------------ELARREKEESEKLKS 431
             +QE ++  R A+ ++ K +  L   LE ++              EL  + ++E   LK 
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 432  ARKQEL---EAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
            A  +E    EAQV E R +  +A ++  E+ E+ +R +    A L +  +T+ ++
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKE 1232



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 20/225 (8%)

Query: 69   REKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE 128
            R  +++EKRR LEAR  +L + ++EEQ  +    + +R +    E+   E   +  +A++
Sbjct: 1724 RNALQDEKRR-LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 129  EQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
             +    A Q L    K+   KL EME  +  K             K   A  E +  + E
Sbjct: 1783 NES---ARQQLERQNKELRSKLHEMEGAVKSKF------------KSTIAALEAKIAQLE 1827

Query: 189  NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQR 248
             + E+   EA E+  A +  +Q + KL+ E LLQ  +E K+ E    + +K    + + +
Sbjct: 1828 EQVEQ---EAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883

Query: 249  WELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEEL 293
             +LE  EEE +++ A R+K +       + N  + R    ++ +L
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 130/528 (24%), Positives = 228/528 (43%), Gaps = 77/528 (14%)

Query: 12   SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
            ++Q  N       E E R    WE+N+             AE       Q  +   Q EK
Sbjct: 636  AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE------LQADLRDIQEEK 689

Query: 72   MK-----EEKRRSLEARREKLRQLMQE-------------EQDLLARELEELRLSMNLQE 113
             +      E R   EA   +L QL QE             E++ L RE   L + +   E
Sbjct: 690  EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749

Query: 114  RR---IREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNP-KLREMELDLHQKHVVNSWEMQ 169
            R    + EQ   L SAKE     + E  L+E  ++N+  ++ + +L++  + V  + E+ 
Sbjct: 750  RDRQDLAEQLQGLSSAKE-----LLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804

Query: 170  KEEKKQQEATAEQENKRYENEYERARRE----------ALERMKA--EEERRQLEDKLQA 217
            + E +  +   + E  + E E + A R+          ALE+ KA  E+E  QL +K + 
Sbjct: 805  QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864

Query: 218  EALLQQMEELKLKEVEATKLKKEQENLLKQRWELE-RLEEERKQMEAFRQKAELGRFLRH 276
            E    Q E           L K  E+L +++ ELE RL+E++ +MEA + + E  R    
Sbjct: 865  ERSWHQQE-----------LAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913

Query: 277  QYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL 336
                Q+   T++  E +     +LQ   E  D SQ+L   R++  +  +   +     Q 
Sbjct: 914  SALCQMQLETEK--ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQT 971

Query: 337  QLERA----REAELQ-----MLLREEAKEMWEKREAEWARERSARDRLMSEVLTGR--QQ 385
            QL+ A    +EA  Q       L+EE+  + + +     +    + +L+++  + R  +Q
Sbjct: 972  QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031

Query: 386  QIQEKIEQNR---RAQEESLKHREQLIRNLEEVRE----LARREKEESEKLKSARKQELE 438
            ++QEK+ + +   R Q+E  + +  L  +L E  +    L   +    ++L + R+   E
Sbjct: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091

Query: 439  AQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYR 486
            AQ  ++ L A     ++E +E+EA  + Q +  L + EA  + EQ  R
Sbjct: 1092 AQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 104/502 (20%), Positives = 231/502 (46%), Gaps = 61/502 (12%)

Query: 16   LNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK-- 73
            L Q LA + E+   LR Q ++  +   M        +    K + +  +   Q ++++  
Sbjct: 1426 LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKC 1485

Query: 74   -----------EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGK 122
                       +E+ + L  +RE++R+L +++++     LE   L +  +++ I  Q G+
Sbjct: 1486 RSVLEHLPMAVQEREQKLTVQREQIREL-EKDRETQRNVLEHQLLELEKKDQMIESQRGQ 1544

Query: 123  LKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQ--EATA 180
            ++  K++   L+  + L    ++N+ K+        Q+ ++   E Q+E ++      T 
Sbjct: 1545 VQDLKKQ---LVTLECLALELEENHHKME------CQQKLIKELEGQRETQRVALTHLTL 1595

Query: 181  EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATK-LKK 239
            + E +  E + + ++   LE       R   E   + ++  +Q+EEL+ ++   T+ L++
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER 1655

Query: 240  EQENLLKQRWELERLEEER-KQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELE---- 294
              + L+ Q+  ++ LE++R +Q +   +  E  +    +   +L+ + Q +QE  E    
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715

Query: 295  ---ADRRILQALL------EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE 345
               A R  L+ +       EKE E Q+ H+   ++       +K  +E+QLQ    +  E
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE-------LKDQLEQQLQGLHRKVGE 1768

Query: 346  LQMLLREEAKEMWE-KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
              +LL +  +E+   +++ + ARE+             ++Q +Q ++++ +RA  +  + 
Sbjct: 1769 TSLLLSQREQEIVVLQQQLQEAREQGEL----------KEQSLQSQLDEAQRALAQRDQE 1818

Query: 405  REQLIRNLEEVRELARREKEESEKLKSARKQE---LEAQVAERRLQAWEADQQEEEEEEE 461
             E L +  ++ +    R KE+++ L+ A +Q    L+ +  E +    +A + EEE   E
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878

Query: 462  ARRVEQLSDALLQQEAETMAEQ 483
             RRV+ L + L    AE+  ++
Sbjct: 1879 GRRVQALEEVLGDLRAESREQE 1900



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 116/508 (22%), Positives = 226/508 (44%), Gaps = 51/508 (10%)

Query: 13   QQRLNQQLARQREQ------------EARLRQQWEQNSRYFRM---SDICSSKQAEWSSK 57
            QQ+L ++L  QRE             E R ++   Q+S+   +   S + + +  E   +
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE 1631

Query: 58   TSYQRS-MHAYQREK---MKEEKRRSLEARREKLRQLMQEEQ-----DLLARELEELRLS 108
               QR  +   QR+K    ++ +RR  E   +K R  + E+Q      +L  +LE+++LS
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLS 1691

Query: 109  MNLQERRIREQHGKLKSAKEEQR-KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWE 167
            +  + R +  Q   ++   EE +    A++   EH K    + +E E++  Q+H+    E
Sbjct: 1692 LRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL-RDKEKEVECQQEHIHELQE 1750

Query: 168  MQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEE- 226
            ++ + ++Q +    +  +      +R +   + + + +E R Q E  L+ ++L  Q++E 
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE--LKEQSLQSQLDEA 1808

Query: 227  ---LKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
               L  ++ E   L++EQ+    Q    ER++E+   ++   ++A +    RH       
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQE---ERVKEKADALQGALEQAHMTLKERHGELQDHK 1865

Query: 284  RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
             + ++++EEL  + R +QAL   E+    L    REQ  A +A  +Q  E+  + E    
Sbjct: 1866 EQARRLEEELAVEGRRVQAL---EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922

Query: 344  AELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRA---QEE 400
            A     L+ +A      +E E  R  S   R   E    R + +QE + +   A   +E+
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982

Query: 401  SLKHREQLIRNLE----------EVRELARREKEESEKLKSARKQELEAQVAERRLQAWE 450
             L  + +L R+LE          +  +   R+ EE+ +++    Q+ + +  E   Q  +
Sbjct: 1983 HLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ 2042

Query: 451  ADQQEEEEEEEARRVEQLSDALLQQEAE 478
            A  Q +EE    +  EQL +  L Q  +
Sbjct: 2043 ALAQRDEELRHQQEREQLLEKSLAQRVQ 2070



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 121/486 (24%), Positives = 218/486 (44%), Gaps = 50/486 (10%)

Query: 18   QQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKR 77
            +QL ++R +E +   + ++ S    M  I   K+ E   +       H ++ +++K++  
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLE-HMKLILRDKEKEVECQQE-----HIHELQELKDQLE 1756

Query: 78   RSLEARREKLRQ----LMQEEQDL--LARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
            + L+    K+ +    L Q EQ++  L ++L+E R    L+E+ ++ Q  + + A   QR
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA-QR 1815

Query: 132  KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
                E L  E  +    + R  E     +  +    M  +E+  +    +++ +R E E 
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875

Query: 192  --ERARREALERMKAEEERRQLEDKLQAEALLQQM-EELKLKEVEATKLKK---EQENLL 245
              E  R +ALE +  +      E +    AL QQ  E+ +  EVE   L+    + + +L
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935

Query: 246  KQR-WELERLEEE----RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE------LE 294
            K+R  ELE L  E    R Q EA R +AE  +    + +A L  + Q + E+      LE
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLE 1995

Query: 295  ADRRILQALLEK-EDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREE 353
            A    LQA L+  +  S++L  A R Q        +  I++Q    +    +LQ  L + 
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEALRIQ--------EGEIQDQDLRYQEDVQQLQQALAQR 2047

Query: 354  AKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLE 413
             +E+  ++E E   E+S   R+       ++  IQEK    +  +EE ++   Q +R L+
Sbjct: 2048 DEELRHQQEREQLLEKSLAQRV-------QENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100

Query: 414  EVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD--QQEEEEEEEARRVEQLSDA 471
                LA++E+E  E  ++ ++  LEA     +    E    + +  E    R +E+L  A
Sbjct: 2101 --LTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAA 2158

Query: 472  LLQQEA 477
            L Q EA
Sbjct: 2159 LRQTEA 2164



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 129/504 (25%), Positives = 234/504 (46%), Gaps = 75/504 (14%)

Query: 17   NQQLARQREQEARLRQQWE----QNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
            N+++  +RE+   L++Q E    Q         + +   AE   +    R     + EK 
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQ-IQELEKQ 1450

Query: 73   KEEKRRSLEARREKLRQLMQEEQDLLARELEELR--------LSMNLQERRI-----REQ 119
            +E ++ +LE     L++  QE  DL   +++EL         L M +QER       REQ
Sbjct: 1451 REMQKAALELLSLDLKKRNQEV-DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509

Query: 120  HGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVN----SWEMQKEEKK- 174
              +L+  +E QR ++  QLL    K    + +  ++   +K +V     + E+++   K 
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKM 1569

Query: 175  --QQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKE- 231
              QQ+   E E +R        +R AL  +  + E R  E  LQA++   Q+ +L+    
Sbjct: 1570 ECQQKLIKELEGQR------ETQRVALTHLTLDLEERSQE--LQAQS--SQIHDLESHST 1619

Query: 232  VEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQE 291
            V A +L++  + +  QR   E++EE ++Q E   Q  E     R      L +   Q+ E
Sbjct: 1620 VLARELQERDQEVKSQR---EQIEELQRQKEHLTQDLE-----RRDQELMLQKERIQVLE 1671

Query: 292  ELEADRRILQA-LLEKEDESQRLHLARR-EQVMADVAWMKQAIEEQLQLERAREAELQ-- 347
                D+R  Q  +LE++ E  +L L  R  ++      M++  EE     +A+   L+  
Sbjct: 1672 ----DQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727

Query: 348  -MLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESL--KH 404
             ++LR++ KE+ E ++      +  +D+L        +QQ+Q     +R+  E SL    
Sbjct: 1728 KLILRDKEKEV-ECQQEHIHELQELKDQL--------EQQLQGL---HRKVGETSLLLSQ 1775

Query: 405  REQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAER--RLQAWEADQQEEEEEEEA 462
            REQ I  L++  + AR + E  E+   ++  E +  +A+R   L+A + +QQ+ + +EE 
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE- 1834

Query: 463  RRVEQLSDAL---LQQEAETMAEQ 483
             RV++ +DAL   L+Q   T+ E+
Sbjct: 1835 -RVKEKADALQGALEQAHMTLKER 1857



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 132/545 (24%), Positives = 220/545 (40%), Gaps = 131/545 (24%)

Query: 20   LARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
            L  QREQE  + QQ  Q +R                     Q  +     +   +E +R+
Sbjct: 1772 LLSQREQEIVVLQQQLQEARE--------------------QGELKEQSLQSQLDEAQRA 1811

Query: 80   LEARREKLRQLMQEEQDLLARE------LEELRLSMNLQERRIREQHGKLKSAKEEQRKL 133
            L  R ++L  L QE+Q    +E       + L+ ++      ++E+HG+L+  KE+ R+L
Sbjct: 1812 LAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871

Query: 134  IAE--------QLLYEHWKKNNPKLREMELDL----------HQKHVVNSWEMQ------ 169
              E        Q L E       + RE E  L           Q+H V +  +Q      
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA 1931

Query: 170  ----KEEKKQQEAT-AEQENKRYENEYERARREALERM--KAEEERRQLEDKLQAEALLQ 222
                KE  ++ EA  AE ++ R++ E  RAR EAL+    KA    +  E  L  +A L 
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991

Query: 223  QMEELKLKEVEAT------KLKKEQENLLKQRWELE----RLEEERKQMEAFRQKAELGR 272
            +  E     ++A+        ++ +E L  Q  E++    R +E+ +Q++  +  A+   
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQ--QALAQRDE 2049

Query: 273  FLRHQYNA-QLSRRT--QQIQEELEADRRILQALLEKED--------ESQRLHLARREQV 321
             LRHQ    QL  ++  Q++QE +  +++ L    E+E+           +L LA++EQ 
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109

Query: 322  MADVAWMKQA--------------IEEQL----QLERAREAELQMLLREEAKEMWEKREA 363
            + ++   +Q               +EEQ      LE   + EL+ L  + A    E RE 
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERL--QAALRQTEAREI 2167

Query: 364  EWARERSARDRLMSEVLT----------------------GRQQQIQEKIEQNRRAQEES 401
            EW RE+ A+D  +S   T                        QQ++Q+++E  RRA E+ 
Sbjct: 2168 EW-REK-AQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225

Query: 402  LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
              H            EL  R  E+  +L      E E        Q+W   Q+ E  ++ 
Sbjct: 2226 RLHSP----GATSTAELGSR-GEQGVQLGEVSGVEAEPSPDGMEKQSWR--QRLEHLQQA 2278

Query: 462  ARRVE 466
              R+E
Sbjct: 2279 VARLE 2283



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 99/434 (22%), Positives = 177/434 (40%), Gaps = 67/434 (15%)

Query: 92   QEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLR 151
            Q+ +D+L  ++++L   +   E    + H +L+     QR+L   Q     W+     L 
Sbjct: 1256 QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL---QRQLSQNQEEKSKWEGKQNSLE 1312

Query: 152  EMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQL 211
               ++LH+        +++ E ++ EA  E+E  +   E   A+ E L+    E   +  
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372

Query: 212  EDKLQAEALLQQMEELKLK------------------EVEATKLKKEQENLLKQRWELER 253
               +  E L      LKLK                  E++  + K  QENL      L  
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432

Query: 254  LEEE----RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ------EELEADRRILQAL 303
             EEE    R Q++   ++ E+ +      +  L +R Q++       +ELE  R +L+ L
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492

Query: 304  LEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREA 363
                 E ++    +REQ+               +LE+ RE + + +L  +  E+ EK++ 
Sbjct: 1493 PMAVQEREQKLTVQREQIR--------------ELEKDRETQ-RNVLEHQLLEL-EKKDQ 1536

Query: 364  EWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREK 423
                +R     L  +++T   + +  ++E+N    E     +++LI+ LE  RE  R   
Sbjct: 1537 MIESQRGQVQDLKKQLVT--LECLALELEENHHKME----CQQKLIKELEGQRETQRVAL 1590

Query: 424  EESEKLKSARKQELEAQ------------VAERRLQA--WEADQQEEEEEEEARRVEQLS 469
                     R QEL+AQ            V  R LQ    E   Q E+ EE  R+ E L+
Sbjct: 1591 THLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLT 1650

Query: 470  DALLQQEAETMAEQ 483
              L +++ E M ++
Sbjct: 1651 QDLERRDQELMLQK 1664



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 112/473 (23%), Positives = 206/473 (43%), Gaps = 73/473 (15%)

Query: 51   QAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMN 110
            QAE   KT+ ++   A+++E         L  + EK R   Q+E   LA+ LE L     
Sbjct: 835  QAEQEGKTALEQQKAAHEKEV------NQLREKWEKERSWHQQE---LAKALESLEREKM 885

Query: 111  LQERRIREQHGKLKS--AKEEQRKLIAEQLLYE---HWKKNNPKLREMELDLHQKHVVNS 165
              E R++EQ  ++++  A+ E+ +  AE  L +     +K    L E  L   ++    S
Sbjct: 886  ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945

Query: 166  WEMQK-------EEKKQQEATAE-----QENKRYENEYERARREALERMKAEEERRQLED 213
             ++++       ++ K+QE T       QE +R   E  R  R+ L  ++ EE    L+D
Sbjct: 946  QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ-EESSSLLQD 1004

Query: 214  KLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRF 273
            K+    L +Q+E+LK + V     ++  E  ++++   E  E  R Q E  R+KA L   
Sbjct: 1005 KMD---LQKQVEDLKSQLVAQDDSQRLVEQEVQEKLR-ETQEYNRIQKELEREKASLTLS 1060

Query: 274  LRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIE 333
            L  +      +R   +QE     ++ L AL +   E+Q      ++++ A +  ++Q ++
Sbjct: 1061 LMEK-----EQRLLVLQEADSIRQQELSALRQDMQEAQ----GEQKELSAQMELLRQEVK 1111

Query: 334  EQLQLERAREAELQMLLREEAKEMWEK--REAEWARERSAR-------------DRLMSE 378
            E+     A+EA  Q+L   EA  + E+  R + WA+E  A              + L +E
Sbjct: 1112 EKEADFLAQEA--QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE 1169

Query: 379  VLTGRQQQIQEKIEQNRRAQEESL----KHREQL---------IRNLEEVRELARREKEE 425
               G Q Q Q ++     A +++L    + R +L         +  LE  +  AR   + 
Sbjct: 1170 QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKR 1229

Query: 426  SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
               L +   + + + + +     W+  Q  +   ++   V++L + L   EAE
Sbjct: 1230 GPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQ---VQKLEERLTDTEAE 1279



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 110/479 (22%), Positives = 205/479 (42%), Gaps = 46/479 (9%)

Query: 22  RQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSM-HAYQREKMKEEKRRSL 80
           R  E  A L Q  +QN  Y +M  I + ++     +T++   M H     +  +E++ SL
Sbjct: 284 RVTELSALLTQSQKQNEDYEKM--IKALRETVEILETNHTELMEHEASLSRNAQEEKLSL 341

Query: 81  EARREKLRQLMQEEQDLLAREL-EELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLL 139
           +   + + Q+M EE D +A+    E  L ++       +     K+    +  L   +  
Sbjct: 342 QQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQA 401

Query: 140 YEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQ--QEATAEQENKR-----YENEYE 192
            +  ++     +E    L Q+H  + WE + +  +Q  Q+ T E++         + E +
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQH--DQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459

Query: 193 RARREALERMKAEEERRQLEDKLQAEA--LLQQMEELKLKEVEATKLKKEQ-ENLLKQRW 249
              +E     KA EE RQ  + L+ EA  L +   EL+L+   A   K+EQ E L     
Sbjct: 460 SLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR 519

Query: 250 ELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDE 309
           E ERL+E    +EA +Q   L   +              ++E LE+   +   LL +E  
Sbjct: 520 ERERLQEMLMGLEA-KQSESLSELIT-------------LREALESSH-LEGELLRQEQT 564

Query: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML----------LREEAKEMWE 359
                LAR EQ +A+++  +  ++ ++   RA   +L  L          L ++  ++ E
Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE 624

Query: 360 KREAEWARERSARD-RLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVREL 418
           + ++  +R  +A   R   +V     ++ +E + +     E  L+  E+    L+     
Sbjct: 625 ENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684

Query: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEA 477
            + EKEE +K  S  + + EA       Q  +  Q+ + +EE   R  Q  +AL++++A
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATT----QLEQLHQEAKRQEEVLARAVQEKEALVREKA 739



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 113/531 (21%), Positives = 221/531 (41%), Gaps = 88/531 (16%)

Query: 15   RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
            R+ ++L  +RE+ +      E+  R   + +  S +Q E S+     +     Q+E    
Sbjct: 1045 RIQKEL--EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE---- 1098

Query: 75   EKRRSLEARREKLRQLMQE-EQDLLARELE-------------ELRLSMNLQERRIREQH 120
                 L A+ E LRQ ++E E D LA+E +             +LR S+  QE +  +  
Sbjct: 1099 -----LSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153

Query: 121  GKLKSAKEEQRKLIAEQ-------------LLYEHWKKNNPKLREM--ELDLHQKHVVNS 165
             +L+S + +   L AEQ              LY   ++    + E   EL        + 
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213

Query: 166  WEMQKEEKKQQ--------------EATAEQENKRYENEYERARREALERMKAEEERRQL 211
            W ++ ++   +              EA A   +K +++ ++  +   + R + ++   +L
Sbjct: 1214 WGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERL 1273

Query: 212  ED----KLQAEALLQQME-ELKLKEVEATKLKKEQENLLKQRWELER----LEEERKQME 262
             D    K Q    LQ ++ +L   + E +K + +Q +L  +  EL      L+   ++ E
Sbjct: 1274 TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE 1333

Query: 263  AFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQA--LLEKEDESQRLHLARREQ 320
              R +A+  R L       L+ + + +Q  +   R    A  +LE++  + R  L  + +
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393

Query: 321  VMADVAWMKQAIEEQLQLERAREAELQMLL---------REEAKEMWEKREAEWARER-- 369
             +       QA++EQ +L+ A+   LQ  L         REE  E    +  E  ++R  
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREM 1453

Query: 370  -SARDRLMSEVLTGRQQQI---QEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEE 425
              A   L+S  L  R Q++   QE+I++  + +   L+H    ++  E+   + R +  E
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQELEKCR-SVLEHLPMAVQEREQKLTVQREQIRE 1512

Query: 426  SEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQE 476
             EK +  ++  LE Q+        E +++++  E +  +V+ L   L+  E
Sbjct: 1513 LEKDRETQRNVLEHQLL-------ELEKKDQMIESQRGQVQDLKKQLVTLE 1556



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 103/486 (21%), Positives = 194/486 (39%), Gaps = 81/486 (16%)

Query: 20  LARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRS 79
           LA+ +E E   ++  E++    ++      ++AE   + + + S    Q +K  E+  + 
Sbjct: 250 LAKTQELE---KEAHERSQELIQLKSQGDLEKAELQDRVT-ELSALLTQSQKQNEDYEKM 305

Query: 80  LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH--GKLKSAKEEQRKLIAEQ 137
           ++A RE +  L     +L+  E     LS N QE ++  Q     +     E+   IA+ 
Sbjct: 306 IKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQG 362

Query: 138 LLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERAR-- 195
             +E+          +ELD     + + ++ Q  +K      +    +R   +  R +  
Sbjct: 363 SGHEN---------SLELD---SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLA 410

Query: 196 --REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
             +EA+  ++ + ++ + E K   + L +   E      +   L+ E ++L K+R  L++
Sbjct: 411 GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQK 470

Query: 254 LEEE-RKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
             EE R+Q+E   Q+A                R +++  EL+      Q   +KE++ + 
Sbjct: 471 AREELRQQLEVLEQEAW---------------RLRRVNVELQLQGDSAQG--QKEEQQEE 513

Query: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
           LHLA RE+             E+LQ         +ML+  EAK+     E    RE    
Sbjct: 514 LHLAVRER-------------ERLQ---------EMLMGLEAKQSESLSELITLREALES 551

Query: 373 DRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL--- 429
             L  E+L   Q ++   + +  ++  E       L   + ++R  A +    +E L   
Sbjct: 552 SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611

Query: 430 KSARKQEL------------EAQVAERRLQAWEADQQEEEEEEEARRVEQLS-DALLQQE 476
           K    Q+L              + AE+   A + D  E E+  EA   +    +A LQ+ 
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

Query: 477 AETMAE 482
            E  AE
Sbjct: 672 EEAGAE 677



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 95/480 (19%), Positives = 188/480 (39%), Gaps = 79/480 (16%)

Query: 24  REQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEAR 83
           RE   +L   W       R  D    K+++W  +  + +     +  ++    R  +  R
Sbjct: 135 REDVEKLTVDWS------RARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFR 188

Query: 84  REKLRQLMQEEQDLLARELEELRLSMNLQE--------RRIREQHGKLKSAKEEQRKLIA 135
           R  L      ++DL+  + E +RLS +L           + RE +G  +    E  +L+ 
Sbjct: 189 RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL 248

Query: 136 EQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERAR 195
             LL         K +E+E + H++          +E  Q ++  + E    ++      
Sbjct: 249 --LL--------AKTQELEKEAHER---------SQELIQLKSQGDLEKAELQDRVTELS 289

Query: 196 REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLE 255
               +  K  E+  ++   L+    + +    +L E EA+  +  QE    ++  L+++ 
Sbjct: 290 ALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQE----EKLSLQQVI 345

Query: 256 EERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHL 315
           ++  Q+    +   + +   H+ + +L        +  +AD+ +            R  L
Sbjct: 346 KDITQV-MVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLV---------RSVL 395

Query: 316 ARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRL 375
            RR Q + D+         + QL   +EA   + L ++  + WE+ E +  R+R  +   
Sbjct: 396 TRRRQAVQDL---------RQQLAGCQEA---VNLLQQQHDQWEE-EGKALRQRLQKLTG 442

Query: 376 MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARR----------EKEE 425
             + L G+   +Q +++   + +E   K RE+L + LE + + A R          + + 
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDS 502

Query: 426 SEKLKSARKQELEAQVAERR-----LQAWEADQQEEEEE----EEARRVEQLSDALLQQE 476
           ++  K  +++EL   V ER      L   EA Q E   E     EA     L   LL+QE
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 88/376 (23%), Positives = 153/376 (40%), Gaps = 71/376 (18%)

Query: 14   QRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMK 73
            Q+L Q LA QR++E R +Q+ EQ         +     A+   +   Q   +  Q E+ +
Sbjct: 2038 QQLQQALA-QRDEELRHQQEREQ---------LLEKSLAQRVQENMIQEKQNLGQ-EREE 2086

Query: 74   EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE-------RRIREQHGKLKSA 126
            EE R   ++ RE    L Q+EQ++L  EL E +   NL+          + EQ  KL S 
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEIL--ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144

Query: 127  KEE-QRKLIAEQLLYEHWKKNNPKLREMELDL-----HQKHVVNSWEMQKEEKKQQEATA 180
            +   QR+L   Q      +    + RE   DL       K  V+S +      +      
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204

Query: 181  EQENKRYENEYERARREALERMKAEE-------------------------ERRQLEDKL 215
            + E +R ++E E  RR ALE+ +                            E     D +
Sbjct: 2205 DSEQQRLQDELELTRR-ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGM 2263

Query: 216  QAEALLQQMEELKLK----EVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG 271
            + ++  Q++E L+      E++ ++L++    L   R  LE++E ER++++    +A   
Sbjct: 2264 EKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQL---RSTLEQVERERRKLKREAMRAAQA 2320

Query: 272  RFLRHQYNAQLSRRTQQ-----------IQEELEADRRILQALLEKEDESQRLHLARREQ 320
              L     A  S  TQQ              EL+ +  +LQA L  E + ++ ++ R  Q
Sbjct: 2321 GSLEIS-KATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQ 2379

Query: 321  VMADVAWMKQAIEEQL 336
               ++A +  ++   L
Sbjct: 2380 TSRELAGLHHSLSHSL 2395



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 90/388 (23%), Positives = 156/388 (40%), Gaps = 57/388 (14%)

Query: 80  LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQ-------RK 132
           +E R   L  +  +   L+  E + L L   + E +      KLK+++E Q       RK
Sbjct: 1   METRSPGLNNMKPQSLQLVLEE-QVLALQQQMAENQAASWR-KLKNSQEAQQRQATLVRK 58

Query: 133 LIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYE 192
           L A+ L Y  W +                         E +K+ EAT     +R+EN  E
Sbjct: 59  LQAKVLQYRSWCQ-------------------------ELEKRLEATGGPIPQRWENVEE 93

Query: 193 RARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLL----KQR 248
               E L R++ E++R +      AE   Q    ++  +V    L+++ E L     + R
Sbjct: 94  PNLDELLVRLEEEQQRCE----SLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRAR 149

Query: 249 WELERLEEERKQMEAFRQ---KAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLE 305
            EL R E + +  + F +   K E GR L   +   ++ R   ++ +   DR +++   E
Sbjct: 150 DELMRKESQWQMEQEFFKGYLKGEHGRLL-SLWREVVTFRRHFLEMKSATDRDLMELKAE 208

Query: 306 KEDES-------QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMW 358
               S        RL +  + +       M      QL L  A+  EL+    E ++E+ 
Sbjct: 209 HVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI 268

Query: 359 EKREAEWARERSARDRL--MSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNL-EEV 415
           + +      +   +DR+  +S +LT  Q+Q  E  E+  +A  E+++  E     L E  
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ-NEDYEKMIKALRETVEILETNHTELMEHE 327

Query: 416 RELARREKEESEKLKSARKQELEAQVAE 443
             L+R  +EE   L+   K   +  V E
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEE 355



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 61/320 (19%)

Query: 195 RREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERL 254
           R   L  MK +  +  LE+  Q  AL QQM E +       KLK  QE   +Q   + +L
Sbjct: 4   RSPGLNNMKPQSLQLVLEE--QVLALQQQMAENQAASWR--KLKNSQEAQQRQATLVRKL 59

Query: 255 EEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLH 314
           + +  Q  ++ Q+ E            + +R + ++E       + + L+  E+E QR  
Sbjct: 60  QAKVLQYRSWCQELEKRL---EATGGPIPQRWENVEEP-----NLDELLVRLEEEQQRC- 110

Query: 315 LARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEM---WEK-------REAE 364
                + +A+V         QL+L   +   +   LRE+ +++   W +       +E++
Sbjct: 111 -----ESLAEV-------NTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQ 158

Query: 365 WARE--------RSARDRLMS---EVLTGRQQQIQEKIEQNRRAQEESLKH--------- 404
           W  E        +    RL+S   EV+T R+  ++ K   +R   E   +H         
Sbjct: 159 WQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLT 218

Query: 405 ---REQLIRNLEEVRELARREKEESEKLKS--ARKQELEAQVAERRLQAWEADQQEEEEE 459
              R  +     E     R +  E  +L    A+ QELE +  ER  +  +   Q + E+
Sbjct: 219 CCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEK 278

Query: 460 EEAR-RVEQLSDALLQQEAE 478
            E + RV +LS  L Q + +
Sbjct: 279 AELQDRVTELSALLTQSQKQ 298


>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
          Length = 1080

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 131/520 (25%), Positives = 229/520 (44%), Gaps = 89/520 (17%)

Query: 12   SQQRLNQQLARQREQ-EARLRQQWEQNSRYFR----MSDICSSKQAEW-------SSKTS 59
            +++ L++QL RQRE  EA +++      +       +S+ C +  AE        + + +
Sbjct: 605  TEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVA 664

Query: 60   YQRSMHAYQREKMKEEKRRSLEARREK-------------LRQLMQEEQDLLARELEELR 106
              ++ H  + +K+KE    + +ARREK             +R L  E Q L+AR  +E+R
Sbjct: 665  QAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVR 724

Query: 107  LSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNS- 165
               +L E  + +   +       Q + + EQL  E       + RE      Q+H+    
Sbjct: 725  RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQE-RERARQRFQQHLEQEQ 783

Query: 166  WEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME 225
            W +Q++ ++     AE+  +         ++ A +R + EE R+QLE+   + AL + + 
Sbjct: 784  WALQQQRQRLYSEVAEERERL-------GQQAARQRAELEELRQQLEES--SSALTRALR 834

Query: 226  ELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRR 285
                   E  K ++EQE   + + EL  L++   Q+E  RQ  E GR  + +  A L  R
Sbjct: 835  ------AEFEKGREEQER--RHQMELNTLKQ---QLELERQAWEAGRTRKEE--AWLLNR 881

Query: 286  TQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAE 345
             Q+++EE+   R          D+   L + R E   AD+A  K+      + E+A E+ 
Sbjct: 882  EQELREEIRKGR----------DKEIELVIHRLE---ADMALAKE------ESEKAAESR 922

Query: 346  LQMLLREEAKEMWEKREAEWA-RERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKH 404
            ++ L  +   E+ E  ++E   +ER +  +       G   ++Q  + Q  RA E++   
Sbjct: 923  IKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 982

Query: 405  REQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE--- 461
             EQL      + ++ R+E E+    + A  +E E + A+  L   +A QQ E EE     
Sbjct: 983  NEQLSSERSNLAQVIRQEFED----RLAASEE-ETRQAKAELATLQARQQLELEEVHRRV 1037

Query: 462  ----ARRVEQLSDALLQQEA--------ETMAEQGYRPKP 489
                AR+ E +S    Q EA        E + EQ  RP P
Sbjct: 1038 KTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTP 1077



 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 110/438 (25%), Positives = 197/438 (44%), Gaps = 73/438 (16%)

Query: 61  QRSMHAYQREKMKEEKRRSLEARREKLRQLMQ----------EEQDLLARELEELRLSMN 110
           QR + A + ++ ++   R L+ +RE     +Q          E++ +L+ + E +   + 
Sbjct: 594 QRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653

Query: 111 LQERRIREQHGKLKSAKEEQRKLI------AEQLLYEHW-KKNNPKLREMELDLHQKHVV 163
            +++R  E+  + ++  E + K +       E+   E W  +   K++E+ +   +  + 
Sbjct: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQ 713

Query: 164 NSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQ 223
                 K+E ++ ++  E E  + +   ERA +  L +  AEE R QLE   + EAL QQ
Sbjct: 714 KLIARHKQEVRRLKSLHEAELLQSD---ERASQRCLRQ--AEELREQLER--EKEALGQQ 766

Query: 224 MEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLS 283
             E           ++ Q++L +++W L++ + +R   E   ++  LG+    Q  A+L 
Sbjct: 767 ERE--------RARQRFQQHLEQEQWALQQ-QRQRLYSEVAEERERLGQQAARQ-RAELE 816

Query: 284 RRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
              QQ++E   A  R L+A  EK  E Q     RR Q+  +       +++QL+LER   
Sbjct: 817 ELRQQLEESSSALTRALRAEFEKGREEQE----RRHQMELNT------LKQQLELER--- 863

Query: 344 AELQMLLREEAKEMWE----KREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRR--- 396
                       + WE    ++E  W   R     L  E+  GR ++I+  I +      
Sbjct: 864 ------------QAWEAGRTRKEEAWLLNRE--QELREEIRKGRDKEIELVIHRLEADMA 909

Query: 397 -AQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAE---RRLQAWEAD 452
            A+EES K  E  I+ L +  E    E E+SE+    R  EL+ Q+ E     L+     
Sbjct: 910 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLV 969

Query: 453 QQEEEEEEEARRV-EQLS 469
           +Q+E   E+A+ V EQLS
Sbjct: 970 RQKERALEDAQAVNEQLS 987



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 89/344 (25%), Positives = 159/344 (46%), Gaps = 38/344 (11%)

Query: 153 MELDLHQKHVVNSWEMQKEEKKQ-----QEATAEQEN--KRYENEYERARREALERMKAE 205
           +EL       V   +++ EEKKQ     Q A A+Q +   R   E E+A    L+R +  
Sbjct: 560 LELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREH 619

Query: 206 EERRQLEDKLQAEALLQQMEELKLK-EVEATKLKKEQENLLKQRWELERLEE-ERKQMEA 263
            E          + L++  + L  K E    +LK+E +   ++  + +   E E K+++ 
Sbjct: 620 YEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKE 679

Query: 264 FRQKAELGRFLRHQYNAQLSRRTQQIQEELEA--DRRILQALLEKEDESQRLHLARREQV 321
                E  R  R ++   +S +T++I+E      +  I + +   + E +RL      ++
Sbjct: 680 LMSATEKAR--REKW---ISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL 734

Query: 322 M-----ADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK--REAEWARERSARDR 374
           +     A    ++QA E + QLER +EA L    RE A++ +++   + +WA ++  R R
Sbjct: 735 LQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRFQQHLEQEQWALQQQ-RQR 792

Query: 375 LMSEVLTGRQQQIQEKIEQNRRAQEESLKHR-----EQLIRNLEEVRELARREKEESEKL 429
           L SEV   R++  Q+   Q  RA+ E L+ +       L R L    E  R E+E   ++
Sbjct: 793 LYSEVAEERERLGQQAARQ--RAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQM 850

Query: 430 K-SARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDAL 472
           + +  KQ+LE +      QAWEA +  +EE     R ++L + +
Sbjct: 851 ELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQELREEI 889


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 96/447 (21%), Positives = 201/447 (44%), Gaps = 45/447 (10%)

Query: 49  SKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLS 108
           S++   S ++  +R +    ++   +++ R+ +  RE+ R+  Q E++   +   E R  
Sbjct: 27  SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKR--ERRRE 84

Query: 109 MNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLH-QKHVVNSWE 167
            +   +R R +  +    KE +R+   E+      ++N  K RE E +   ++      +
Sbjct: 85  KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTD 144

Query: 168 MQKEEKKQQEATAEQE---NKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQM 224
            Q+E ++Q++A  E+E   ++  + + ER R++  ER K  +ERR+ E + + E   +  
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204

Query: 225 EELKLKEVEA---TKLKKEQENLLKQRWELERLEEERKQMEAFRQKA-----ELGRFLRH 276
              + +E E    T+ + E++    +  + +R  E  ++ +A R++A     E  +    
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264

Query: 277 QYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQL 336
           + +    R  +Q + E + DR+  Q   E++ E++R    +RE+        K+  E + 
Sbjct: 265 ERDRDRDRDRRQKERERQTDRK-RQRRTERDRETERKRERQRERERERERNRKRERERER 323

Query: 337 QLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQ--QQIQEKIEQN 394
           + ER R+ E +   RE+ +E   KR+ E  RER+ +        TGR+  +Q + + E+ 
Sbjct: 324 ERERERQRETERD-REKERERKRKRQTEMDRERNRQ--------TGREGRRQAERERERE 374

Query: 395 RRAQEESLKHREQLIRNLE-------------------EVRELARREKEESEKLKSARKQ 435
           R    +S + RE+  R+ +                   E  +   REK+   +    R +
Sbjct: 375 RERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR 434

Query: 436 ELEAQVAERRLQAWEADQQEEEEEEEA 462
           E E Q    R +  + D+Q   + + +
Sbjct: 435 EREKQKGRERDRERQTDRQAGRQRKRS 461



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 103/467 (22%), Positives = 189/467 (40%), Gaps = 62/467 (13%)

Query: 25  EQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKEEKRRSLEARR 84
           +   R RQ+  +  R  R ++  + ++ E   +    R    ++  +   EK R  +  R
Sbjct: 52  DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111

Query: 85  EKLRQLMQEEQDLLARELEELRLSMNLQERRI---REQHGKLKSAKEEQRKLIAEQLLYE 141
           E+ RQ  +E      RE E  R     ++R+    RE+  +  + KE +R+   E+    
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRER--QR 169

Query: 142 HWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALER 201
             ++N  K RE E +  ++      E +++ +K+ +       +  E E ER      ER
Sbjct: 170 QTERNRQKEREREKNRQERR-----ERERQREKENKTEDRHSERGRERERERETETETER 224

Query: 202 MKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLEEERKQM 261
            +  +  R  + K + E   +Q E  +  E E  + K+ +    + R    R +E  +Q 
Sbjct: 225 KRQTDRERDRQRKTERER-EKQAERERASERETERDKERERERDRDRDRDRRQKERERQT 283

Query: 262 EAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQV 321
           +  RQ+               + R ++ + + E  R       E+E E +R     RE+ 
Sbjct: 284 DRKRQRR--------------TERDRETERKRERQR-------ERERERERNRKRERER- 321

Query: 322 MADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLT 381
                      E + + ER RE E     RE+ +E   KR+ E  RER+ +        T
Sbjct: 322 -----------ERERERERQRETERD---REKERERKRKRQTEMDRERNRQ--------T 359

Query: 382 GRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQV 441
           GR+ + Q + E+ R  + +    RE+  R  +  R+   R+KE   + +  R  + E + 
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRD---RQKERERQTEKDRDGQRETEK 416

Query: 442 AERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK 488
              R    E D++ E   E  R  E+       +E +T  + G + K
Sbjct: 417 QRER----EKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 99/436 (22%), Positives = 192/436 (44%), Gaps = 44/436 (10%)

Query: 13  QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRS-MHAYQREK 71
           ++R  +Q  R+ +++   R++ +++ +  R  +    ++ E   +T  +R      +R +
Sbjct: 64  RRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNR 123

Query: 72  MKEEKRRS-LEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQ 130
            KE +R +  E  R + RQ   + +    R+ E+ R     +ER+ + +  + K  + E+
Sbjct: 124 QKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK 183

Query: 131 RKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENE 190
            +    +   +  K+N  + R  E    ++      E + E K+Q +   +++ K     
Sbjct: 184 NRQERRERERQREKENKTEDRHSERG-RERERERETETETERKRQTDRERDRQRKT---- 238

Query: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
            ER R +  ER +A E   + + + + E    +  + + KE E    +K Q    + R E
Sbjct: 239 -EREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR-E 296

Query: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
            ER  E +++ E  R++       R +   +   R ++ Q E E DR       EKE E 
Sbjct: 297 TERKRERQRERERERERN------RKRERERERERERERQRETERDR-------EKERER 343

Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
           +R    +R+  M      +   E + Q ER RE E              +R+ + ARER 
Sbjct: 344 KR----KRQTEMDRERNRQTGREGRRQAERERERE-------------RERDRQSARERE 386

Query: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHRE-QLIRNLEEVRELARREKEESEKL 429
            R+R        RQ++ + + E++R  Q E+ K RE +  R  E  RE   RE+E+ +  
Sbjct: 387 ERERDRDR---DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG-REREKQKGR 442

Query: 430 KSARKQELEAQVAERR 445
           +  R+++ + Q   +R
Sbjct: 443 ERDRERQTDRQAGRQR 458



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 69/306 (22%), Positives = 135/306 (44%), Gaps = 13/306 (4%)

Query: 174 KQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVE 233
           K  +    + N++ E E  R +R+       + ERR+ +D+ +     ++ +  + KE E
Sbjct: 47  KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106

Query: 234 -ATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELG-RFLRHQYNAQLSRRTQQIQE 291
             T  +++++   ++  + ER  E  ++ E  R +   G R    Q +A+  R  Q  +E
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166

Query: 292 ELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLR 351
                 R  Q   E+E E  R     RE+        K+   E    ER RE E +   R
Sbjct: 167 RQRQTERNRQK--EREREKNRQERRERERQRE-----KENKTEDRHSERGRERERE---R 216

Query: 352 EEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRN 411
           E   E   KR+ +  R+R  +     E    R++  + + E+++  + E  + R++  R 
Sbjct: 217 ETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQ 276

Query: 412 LEEVRELARREKEESEK-LKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSD 470
            E  R+  R+ +  +E+  ++ RK+E + +    R +  + +++ E E E  R+ E   D
Sbjct: 277 KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336

Query: 471 ALLQQE 476
              ++E
Sbjct: 337 REKERE 342



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 79/360 (21%), Positives = 155/360 (43%), Gaps = 54/360 (15%)

Query: 12  SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
           +++   +Q  R+R+++    +Q E+                    K   +R     QREK
Sbjct: 155 AEKERERQTDRERQRQTERNRQKERE-----------------REKNRQERRERERQREK 197

Query: 72  MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
             + + R  E  RE+ R+   E +    R+ +             RE+  + K+ +E ++
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTD-------------RERDRQRKTEREREK 244

Query: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
           +   E+      +++  + RE + D  +       E Q + K+Q+    ++E +R + E 
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER-KRER 303

Query: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
           +R R    ER +  E  R+           ++ E  + +E E  + +KE+E   K++ E+
Sbjct: 304 QRERERERERNRKRERERE-----------RERERERQRETERDR-EKERERKRKRQTEM 351

Query: 252 ERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADR-RILQALLEKEDES 310
           +R E  R+     R++AE  R    + + Q +R  ++ + + + DR +  +   EK+ + 
Sbjct: 352 DR-ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410

Query: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
           QR    +RE+        ++  E +   ER RE E Q   RE  +E    R+A   R+RS
Sbjct: 411 QRETEKQRER--------EKDRESERGRERGREREKQK-GRERDRERQTDRQAGRQRKRS 461


>gi|44890059 involucrin [Homo sapiens]
          Length = 585

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 118/513 (23%), Positives = 238/513 (46%), Gaps = 54/513 (10%)

Query: 2   ALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQ 61
           A+  LP   C QQ+   Q     EQE + +Q WEQ+  Y         K      +   +
Sbjct: 66  AVKGLPEQECEQQQKEPQ-----EQELQ-QQHWEQHEEY--------QKAENPEQQLKQE 111

Query: 62  RSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHG 121
           ++    Q  K  EE+++ L+ + ++      E+  +   +L EL        + + +Q G
Sbjct: 112 KTQRDQQLNKQLEEEKKLLDQQLDQELVKRDEQLGMKKEQLLELPEQQEGHLKHLEQQEG 171

Query: 122 KLKSAKEEQRKL-IAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA 180
           +LK  ++++ +L + EQ   +  +   P+ +E +L+L ++      E Q E  +QQE   
Sbjct: 172 QLKHPEQQEGQLELPEQ---QEGQLELPEQQEGQLELPEQQ-----EGQLELPEQQEGQL 223

Query: 181 EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQME----ELKLKEVEATK 236
           E   ++ E + E  +++  +   +E++  QLE   Q E  L+ +E    +L++ E +  +
Sbjct: 224 ELPEQQ-EGQLELPQQQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQ 282

Query: 237 LKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ-EELEA 295
           LK     L +Q  +L+ L+++ KQ E   Q+    + L  Q         Q+ Q E+LE 
Sbjct: 283 LKY----LEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEE 338

Query: 296 DRRILQALLEKEDESQRLHLARREQVMA----DVAWMKQAIEEQLQLERAREAELQM--L 349
               L+ L  ++ E Q  HL  +E  +      V  +KQ  ++Q Q +   E E Q+  L
Sbjct: 339 QEGQLKHL--EQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHL 396

Query: 350 LREEAK-EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQL 408
           +++E + +   ++E +  ++    + L  +V   +  + QE   ++   Q+  L+  EQ 
Sbjct: 397 VQQEGQLKHLVQQEGQLEQQERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQ 456

Query: 409 I---RNLEEVRELARREKEESEKLKSARKQELEAQVAERRL-QAWEADQQE------EEE 458
           +   +NLE+  +     +++  ++K   KQE + ++ E+++ Q    +QQE      E++
Sbjct: 457 VGQPKNLEQEEKQLELPEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQEKHLEHPEQQ 516

Query: 459 EEEARRVEQLSDAL--LQQEAETMAEQGYRPKP 489
           + + + +EQ    L  L+Q+   + +  + P P
Sbjct: 517 DGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAP 549



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 74/313 (23%), Positives = 150/313 (47%), Gaps = 35/313 (11%)

Query: 177 EATAEQENKRY-------ENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKL 229
           E  ++QE K         E E E+ ++E  E+   ++   Q E+  +AE   QQ+++ K 
Sbjct: 54  EVPSKQEEKHMTAVKGLPEQECEQQQKEPQEQELQQQHWEQHEEYQKAENPEQQLKQEKT 113

Query: 230 -KEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQ 288
            ++ +  K  +E++ LL Q+ + E +    K+ E    K E    L  Q    L    QQ
Sbjct: 114 QRDQQLNKQLEEEKKLLDQQLDQELV----KRDEQLGMKKEQLLELPEQQEGHLKHLEQQ 169

Query: 289 IQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQM 348
             +    +++  Q  L ++ E Q L L  ++             E QL+L   +E +L++
Sbjct: 170 EGQLKHPEQQEGQLELPEQQEGQ-LELPEQQ-------------EGQLELPEQQEGQLEL 215

Query: 349 LLREEAK-EMWEKREAEWARERSARDRL-MSEVLTGRQQQIQEKIEQNRRAQEESLKHRE 406
             ++E + E+ E++E +    +    +L +SE     QQ+ Q ++ + +  Q + L+H+E
Sbjct: 216 PEQQEGQLELPEQQEGQLELPQQQEGQLELSE-----QQEGQLELSEQQEGQLKHLEHQE 270

Query: 407 -QLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRV 465
            QL    E++ +L   E++E + LK   +QE + ++ E+++   +  +Q+E + +   + 
Sbjct: 271 GQLEVPEEQMGQLKYLEQQEGQ-LKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQ 329

Query: 466 EQLSDALLQQEAE 478
           E   + L +QE +
Sbjct: 330 EGQLEQLEEQEGQ 342



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 76/371 (20%), Positives = 160/371 (43%), Gaps = 46/371 (12%)

Query: 13  QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
           QQ    +L+ Q+E +  L +Q E   ++    +       E   +  Y        +   
Sbjct: 238 QQEGQLELSEQQEGQLELSEQQEGQLKHLEHQEGQLEVPEEQMGQLKYLEQQEGQLKHLD 297

Query: 73  KEEKRRSL-EARREKLRQLMQEEQDLLARELEELRLSMNLQE----RRIREQHGKLKSAK 127
           ++EK+  L E +  +L+ L Q+E      E +E +L    ++    + + +Q G+L+  +
Sbjct: 298 QQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHLEQQEGQLEHLE 357

Query: 128 EEQRKL-IAEQ--LLYEHWKKNNPKLREMELDLHQ-KHVVNSWEMQKEEKKQQEATAEQE 183
            ++ +L + EQ  L  +  +K   + + +E +  Q KH+V   E Q +   QQE   EQ+
Sbjct: 358 HQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQ-EGQLKHLVQQEGQLEQQ 416

Query: 184 NKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQEN 243
               E + E   ++  +    EE+  QL+   Q +  L+  E+   +     + +K+ E 
Sbjct: 417 ----ERQVEHLEQQVGQLKHLEEQEGQLKHLEQQQGQLEVPEQQVGQPKNLEQEEKQLEL 472

Query: 244 LLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQAL 303
             +Q  +++ LE++  Q+E   Q+    + L  Q            ++ LE         
Sbjct: 473 PEQQEGQVKHLEKQEAQLELPEQQVGQPKHLEQQ------------EKHLEH-------- 512

Query: 304 LEKEDESQRLHLARREQVMADVAWMKQAIEEQL---------QLERAREAELQMLLREEA 354
             ++ + Q  HL ++E  + D+   K  +E+ +          ++ A   + ++LL  E 
Sbjct: 513 -PEQQDGQLKHLEQQEGQLKDLEQQKGQLEQPVFAPAPGQVQDIQPALPTKGEVLLPVEH 571

Query: 355 KEMWEKREAEW 365
           ++  +K+E +W
Sbjct: 572 QQ--QKQEVQW 580



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 17/74 (22%), Positives = 43/74 (58%), Gaps = 2/74 (2%)

Query: 410 RNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLS 469
           +++  V+ L  +E E+ +K    ++QEL+ Q  E+  +  +A+  E++ ++E  + +Q  
Sbjct: 62  KHMTAVKGLPEQECEQQQK--EPQEQELQQQHWEQHEEYQKAENPEQQLKQEKTQRDQQL 119

Query: 470 DALLQQEAETMAEQ 483
           +  L++E + + +Q
Sbjct: 120 NKQLEEEKKLLDQQ 133


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.123    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,037,798
Number of Sequences: 37866
Number of extensions: 903206
Number of successful extensions: 43441
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 769
Number of HSP's successfully gapped in prelim test: 1412
Number of HSP's that attempted gapping in prelim test: 9335
Number of HSP's gapped (non-prelim): 12255
length of query: 498
length of database: 18,247,518
effective HSP length: 106
effective length of query: 392
effective length of database: 14,233,722
effective search space: 5579619024
effective search space used: 5579619024
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press