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Search of human proteins with 219521893
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219521893 coiled-coil transcriptional coactivator isoform 2
[Homo sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219521893 coiled-coil transcriptional coactivator isoform 2 [... 1182 0.0
gi|14149742 coiled-coil transcriptional coactivator isoform 1 [H... 1141 0.0
gi|119943086 Tax1 (human T-cell leukemia virus type I) binding p... 190 3e-48
gi|21361682 Tax1 (human T-cell leukemia virus type I) binding pr... 186 7e-47
gi|31982906 cingulin-like 1 [Homo sapiens] 88 3e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 83 6e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 82 1e-15
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 81 2e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens] 81 2e-15
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens] 81 2e-15
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 81 3e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 80 5e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 80 5e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 80 5e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 80 5e-15
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 80 7e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 79 1e-14
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 79 1e-14
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 78 2e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 78 2e-14
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 78 2e-14
gi|16262452 cingulin [Homo sapiens] 77 5e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 76 1e-13
gi|71061468 centromere protein E [Homo sapiens] 75 2e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 3e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 3e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 3e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 3e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 3e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 3e-13
>gi|219521893 coiled-coil transcriptional coactivator isoform 2
[Homo sapiens]
Length = 606
Score = 1182 bits (3058), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD
Sbjct: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
Query: 61 YHTFVWSSVPESTTDGSPIHTSVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQL 120
YHTFVWSSVPESTTDGSPIHTSVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQL
Sbjct: 61 YHTFVWSSVPESTTDGSPIHTSVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQL 120
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT
Sbjct: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK
Sbjct: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL
Sbjct: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
Query: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 360
EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT
Sbjct: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 360
Query: 361 QNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEA 420
QNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEA
Sbjct: 361 QNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEA 420
Query: 421 RLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPA 480
RLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPA
Sbjct: 421 RLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPA 480
Query: 481 GPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELG 540
GPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELG
Sbjct: 481 GPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELG 540
Query: 541 SAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQ 600
SAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQ
Sbjct: 541 SAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQ 600
Query: 601 DPFTFE 606
DPFTFE
Sbjct: 601 DPFTFE 606
>gi|14149742 coiled-coil transcriptional coactivator isoform 1 [Homo
sapiens]
Length = 691
Score = 1141 bits (2951), Expect = 0.0
Identities = 606/691 (87%), Positives = 606/691 (87%), Gaps = 85/691 (12%)
Query: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD
Sbjct: 1 MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD 60
Query: 61 YHTFVWSSVPESTTDGSPIHTSVQFQ---------------------------------E 87
YHTFVWSSVPESTTDGSPIHTSVQFQ E
Sbjct: 61 YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE 120
Query: 88 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 147
PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR
Sbjct: 121 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 180
Query: 148 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 207
VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI
Sbjct: 181 VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI 240
Query: 208 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL-------------- 253
SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL
Sbjct: 241 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL 300
Query: 254 --------------------------------------EPLKEQLRGAQELAASSQQKAT 275
EPLKEQLRGAQELAASSQQKAT
Sbjct: 301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT 360
Query: 276 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 335
LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE
Sbjct: 361 LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE 420
Query: 336 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 395
AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR
Sbjct: 421 AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR 480
Query: 396 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 455
VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE
Sbjct: 481 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE 540
Query: 456 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 515
DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE
Sbjct: 541 DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE 600
Query: 516 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 575
DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK
Sbjct: 601 DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK 660
Query: 576 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 606
ERFPAESDKDALEDHMDGHFFFSTQDPFTFE
Sbjct: 661 ERFPAESDKDALEDHMDGHFFFSTQDPFTFE 691
>gi|119943086 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform b [Homo sapiens]
Length = 747
Score = 190 bits (483), Expect = 3e-48
Identities = 188/746 (25%), Positives = 308/746 (41%), Gaps = 188/746 (25%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
Query: 75 DGSPIH---------------------------------TSVQFQEPRPMDELVTLEEAD 101
+GS ++ T QF+ P++EL+T+E+ +
Sbjct: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
Query: 102 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 161
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
Query: 162 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Query: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPL------------------------- 256
+D +K E+E+L QLK + +KE + L+
Sbjct: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
Query: 257 ----------------KEQLRGAQELAASSQQKATLLGE--------------------- 279
KE L+ L SS++ L E
Sbjct: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
Query: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
Query: 340 KILKLS------------AEILRLEKAVQE-------------ERTQNQ----------- 363
+ LKL E RL+K + + ++T NQ
Sbjct: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
Query: 364 ---------VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 414
V + A E D +V + E+ K K+ LQ+EK + +Y
Sbjct: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
Query: 415 MRKLEARLE-------KVADEKWNEDATTED--EEAAVGLSCPA--ALTDSEDES--PED 461
+L A++E K+A+ E A +D +E L PA + D D + P++
Sbjct: 556 ADEL-AKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEDGADGAFYPDE 614
Query: 462 MRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVL 521
++ PP + G VV SQPA + S P S+ EDE
Sbjct: 615 IQRPPVRVPSWG-----------LEDNVVCSQPA---RNFSRPDGLEDSEDSKEDEN--- 657
Query: 522 MAAVQSGGEEANLLLPELGSAFYDMASGFTV------------GTLSETSTGGPATPTWK 569
V + + + L G+ F S F V ++ WK
Sbjct: 658 ---VPTAPDPPSQHLRGHGTGFC-FDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWK 713
Query: 570 ECPICKERFPAESDKDALEDHMDGHF 595
CP+C E+FP + D+ E H+ HF
Sbjct: 714 VCPMCSEQFPPDYDQQVFERHVQTHF 739
>gi|21361682 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform a [Homo sapiens]
Length = 789
Score = 186 bits (471), Expect = 7e-47
Identities = 181/753 (24%), Positives = 304/753 (40%), Gaps = 187/753 (24%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F NVA++Y+PN +ECHYTL P P DW+GIFKV + RDY+TF+WS +PE
Sbjct: 17 VIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYV 76
Query: 75 DGSPIH---------------------------------TSVQFQEPRPMDELVTLEEAD 101
+GS ++ T QF+ P++EL+T+E+ +
Sbjct: 77 EGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMED-E 135
Query: 102 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 161
G SD+L+V KA +L+ +++++ +E+ +L++L LE + +LR +V +ER L ++
Sbjct: 136 GNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKER 195
Query: 162 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
+L + KG++ + E + ++ D ++ +LE+DI +++ K + KE ELD L
Sbjct: 196 CDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSL 255
Query: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPL------------------------- 256
+D +K E+E+L QLK + +KE + L+
Sbjct: 256 KDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVI 315
Query: 257 ----------------KEQLRGAQELAASSQQKATLLGE--------------------- 279
KE L+ L SS++ L E
Sbjct: 316 THFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAK 375
Query: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
EL+ A RDRT+A+LH +RLE +V +LA+ LK + +++ L+ +
Sbjct: 376 ELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREV 435
Query: 340 KILKLS------------AEILRLEKAVQE-------------ERTQNQ----------- 363
+ LKL E RL+K + + ++T NQ
Sbjct: 436 EDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTD 495
Query: 364 ---------VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 414
V + A E D +V + E+ K K+ LQ+EK + +Y
Sbjct: 496 PATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKY 555
Query: 415 MRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGD 474
+L A++E KW E E + L A + D+ E + P ER
Sbjct: 556 ADEL-AKMEL----KWKEQVKIA-ENVKLEL---AEVQDNYKELKRSLENP----AERKM 602
Query: 475 PGSSPAGPR-------EASPLVVISQPAPI----SPHLSGPAEDSSSDSEAEDEKSVLMA 523
G + P+ + ++ +S P+ +P+ S D + + DE
Sbjct: 603 EGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPV 662
Query: 524 AVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATP----------------- 566
V S G E N++ + F G S+ P P
Sbjct: 663 RVPSWGLEDNVVCSQPARNF-SRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFD 721
Query: 567 ----TWKECPICKERFPAESDKDALEDHMDGHF 595
K+CP+C+ FP D+ E+H++ H+
Sbjct: 722 SSFDVHKKCPLCELMFPPNYDQSKFEEHVESHW 754
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 87.8 bits (216), Expect = 3e-17
Identities = 81/316 (25%), Positives = 145/316 (45%), Gaps = 16/316 (5%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L++Q +E +E + L Q + EG ELR ++EL + Q TE+ + +S
Sbjct: 654 LRSQHNEKVEENSTLQQRLEESEG---ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
H E+ + R++G + +L+ + D+Q + ++ KE + D LR + LT L
Sbjct: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDL---LIAKEEQEDLLRKRERELT----AL 763
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 295
G LKE + +Q E++ LKEQ + S ++AT E LAS + ++ A
Sbjct: 764 KGALKEEVSSHDQ---EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
Query: 296 HRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
+ E N +L L+ Q ++ L K+ + K EI +LE+A+
Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
Query: 356 ---QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
++E + + L E +++ LS++ +E +L L+ ++KEQL+ K E+
Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
Query: 413 EYMRKLEARLEKVADE 428
L +EK+ E
Sbjct: 941 NERWHLGKTIEKLQKE 956
Score = 68.2 bits (165), Expect = 2e-11
Identities = 85/360 (23%), Positives = 154/360 (42%), Gaps = 50/360 (13%)
Query: 116 LQNQLDE-SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ-YKGIS 173
LQNQLDE ++ R +L +++ QL+ + E E R A Q+ LME+ +
Sbjct: 971 LQNQLDEYKEKNRRELAEMQRQLKEKTLEA-----EKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
R+ E +R +L + D LE +++ S L+D L ++ E
Sbjct: 1026 RAQDEALTKRQLLEQTLKD-------LEYELEAKSH-----------LKDDRSRLVKQME 1067
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
+ QL E++ ++E++ ++L ++ ++ S +Q L E L AA +D
Sbjct: 1068 DKVSQL-EMELEEERNNSDLL--------SERISRSREQMEQLRNELLQERAARQDLECD 1118
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEK----CQWSKERAGLLQSVEAEKDKILKLSAEIL 349
++ R + ++ R+ L + K Q A L +E+E+ L
Sbjct: 1119 KISLER-QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR 1177
Query: 350 RLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ 409
RLE+ V+E Q L +KD ++L KR++ E + L+ K++LQ E +
Sbjct: 1178 RLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
Query: 410 ELLEYMRKLEARLE--------KVADEKWNEDATTEDEEAAVGLS---CPAALTDSEDES 458
E ++ L+ +L K K +D +D+ + G S P + T S+D +
Sbjct: 1238 EQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDST 1297
Score = 65.9 bits (159), Expect = 1e-10
Identities = 77/337 (22%), Positives = 153/337 (45%), Gaps = 36/337 (10%)
Query: 115 VLQNQLDESQQERNDL-MQLKL------QLEGQVTELRSRVQELERALATARQEHTELME 167
VL ++ + S+Q++ M++KL +L+G+ EL RV +L+R + + + + E
Sbjct: 805 VLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 168 QYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA 227
K + GEI + + L + +++ + +S + E EL+ + +
Sbjct: 865 TLK---KYEGEIRQLEEALVHAR----------KEEKEAVSAR-RALENELEAAQGNLSQ 910
Query: 228 LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 287
T+EQ++L +LKE KEQ L LK ++ + + +K L +E+A A
Sbjct: 911 TTQEQKQLSEKLKEESEQKEQ----LRRLKNEMENERWHLGKTIEK---LQKEMADIVEA 963
Query: 288 RDRTIAELHRSRLEVAEVNGR-LAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSA 346
+ EL E E N R LAE+ LKE+ + K R ++ +D++ +
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM----QDEMRLMEE 1019
Query: 347 EILRLEKAVQEERTQNQVFK---TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ 403
E+ ++A E T+ Q+ + +L E ++ + R + ++ + L+ E E+
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
Query: 404 LQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
+ L E + + ++E++ +E E A +D E
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116
Score = 59.3 bits (142), Expect = 1e-08
Identities = 73/351 (20%), Positives = 145/351 (41%), Gaps = 57/351 (16%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQ-VTELRSRVQ---ELERALATARQEHTELMEQYK 170
+L N L E + +D + K+ L + + L+SR + + E +L+EQ
Sbjct: 558 ILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKS 617
Query: 171 GISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR 230
++ E+ + + + Q + + +++ + + K E L+ ++
Sbjct: 618 KLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG 677
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDR 290
E K L +L +V+ ++EQ + E+ L++QL + + +EL SA + DR
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQDQL--------------SEMHDELDSAKRSEDR 723
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 350
E G L EE Q ++ LL + E ++D + K E+
Sbjct: 724 --------------------EKGA-LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA 762
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL---------------- 394
L+ A++EE + + +L + D+ L L ES E T+ L
Sbjct: 763 LKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 395 --RVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 443
++LQ+E E+LQ +EL + +L+ ++E + ++ T + E +
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI 873
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 83.2 bits (204), Expect = 6e-16
Identities = 80/355 (22%), Positives = 159/355 (44%), Gaps = 34/355 (9%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TE 164
K + +L++ ++ +L K +LE + +EL+ + +LE LA +E
Sbjct: 918 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKN 977
Query: 165 LMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDT 224
L E+ G+ ++T+E+ L + + ED + T+++ + E ++D L +
Sbjct: 978 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS 1037
Query: 225 VKA-------LTREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASS 270
++ L R + KL G LK +++ DK+Q + L+ +L
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Query: 271 QQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL 330
Q + L ++L A + EL R A+V ++L L E+ E AG
Sbjct: 1098 QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL--EEISERLEEAGG 1155
Query: 331 LQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTEL 390
SV+ E +K K AE ++ + ++E Q++ L ++ S+ +L E ++ L
Sbjct: 1156 ATSVQIEMNK--KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE---QIDNL 1210
Query: 391 RSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA---DEKWNEDATTEDE 439
+ + L+KEK + + E ++ +E + K +A LEK+ +++ NE + +E
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEE 1265
Score = 77.4 bits (189), Expect = 4e-14
Identities = 72/320 (22%), Positives = 142/320 (44%), Gaps = 16/320 (5%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
LQ LD + RN+ +++K ++EG + E+ ++ R A A+++ L K
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
R++ ++ E I+ R+ A + EL ++ E EL + V+ L
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1716
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ L+ Q K++ AD Q + E+E ++ R A+E A + A ++ EEL
Sbjct: 1717 HSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK----E 1772
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAE 347
T A L R + + + + +L L E + K LQ +EA ++ +L AE
Sbjct: 1773 QDTSAHLERMKKNMEQT---IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
R ++V+ R + K EL + + L + + +L+ ++ +++ E+ +E+
Sbjct: 1830 QKRNAESVKGMRKSERRIK-ELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Query: 408 KQELLEYMRKLEARLEKVAD 427
L RK++ L++ +
Sbjct: 1889 ANTNLSKFRKVQHELDEAEE 1908
Score = 67.8 bits (164), Expect = 3e-11
Identities = 68/329 (20%), Positives = 147/329 (44%), Gaps = 32/329 (9%)
Query: 118 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHG 177
+ +++ + + +L ++ LE Q+ E RS+ +E +R++ + +L + +SR
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR--- 1289
Query: 178 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEV----------ELDRLRDTVKA 227
++ E+ ++S+ + +LED + + E+V K + D LR+ +
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 228 LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLL--GEELASAA 285
T + +L L + ++ Q + E + ++ +EL + ++ A L EE A
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 286 AARDRTIAEL-HRSRLEVAEV-----NGRLAELGLHLKEEK-----CQWSKERAGLLQSV 334
A+ ++ + HR + E+ ++ A L K+ +W ++ +
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Query: 335 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL 394
E+ + + LS E+ +L+ A +E + FK RE + ++S+ +L +
Sbjct: 1468 ESSQKEARSLSTELFKLKNAYEESLEHLETFK----RENKNLQEEISDLTEQLGSSGKTI 1523
Query: 395 RVLQKEKEQLQEEKQELLEYMRKLEARLE 423
L+K ++QL+ EK EL + + EA LE
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLE 1552
Score = 66.2 bits (160), Expect = 8e-11
Identities = 73/339 (21%), Positives = 142/339 (41%), Gaps = 38/339 (11%)
Query: 117 QNQLDESQQER---NDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
Q LD+ Q E N L + K++LE QV +L +++ ++ + +L K
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK--- 1060
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
+T+E I++LE+D Q + E++ K+ EL+ L ++
Sbjct: 1061 -----LTQES-------------IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS 1102
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
+L +LKE+QA E+ E ELE + ++L + ++ + E L A A I
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 353
+ E ++ L E L + K+ A D + +L +I L++
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA----------DSVAELGEQIDNLQR 1212
Query: 354 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 413
Q+ + FK EL + S++ Q+ ++K L ++ R L+ + + + + +E
Sbjct: 1213 VKQKLEKEKSEFKLEL-DDVTSNMEQIIKAKANLEKM---CRTLEDQMNEHRSKAEETQR 1268
Query: 414 YMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALT 452
+ L ++ K+ E +++EA + LT
Sbjct: 1269 SVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307
Score = 58.9 bits (141), Expect = 1e-08
Identities = 73/338 (21%), Positives = 148/338 (43%), Gaps = 32/338 (9%)
Query: 117 QNQLDESQQERN-----------DLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL 165
+ QLDE ++++ D L QL+ ++ EL++R++ELE L R ++
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 166 MEQYKGISRSHGEITEERD----ILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
+ +SR EI+E + S Q + R E + + + E L E L
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 222 R----DTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLL 277
R D+V L + + L ++++ +K + + EL+ + + + A+ ++ L
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 278 GEEL---ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 334
+++ S A R++ +L R ++ NG EL L E++ S+ G L
Sbjct: 1253 EDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG---ELSRQLDEKEALISQLTRGKLTYT 1309
Query: 335 EAEKDKILKLSAEIL---RLEKAVQEERTQNQVFKTELAREKDSSLV---QLSESKRELT 388
+ +D +L E+ L A+Q R + + + E ++ LS++ E+
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 389 ELRSALRV-LQKEKEQLQEEKQELLEYMRKLEARLEKV 425
+ R+ + E+L+E K++L + +++ E +E V
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Score = 46.2 bits (108), Expect = 9e-05
Identities = 47/196 (23%), Positives = 88/196 (44%), Gaps = 30/196 (15%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
KL ++K + E+ E E+ +KE+ +E S+ + L E++ S +
Sbjct: 831 KLYFKIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL-------LQ 882
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 353
E + +L+V LA+ EE+C + K+KI +L A++ + +
Sbjct: 883 EKNDLQLQVQAEQDNLADA-----EERCD------------QLIKNKI-QLEAKVKEMNE 924
Query: 354 AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLE 413
+++E N EL +K + SE KR++ +L L ++KEK + + + L E
Sbjct: 925 RLEDEEEMN----AELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE 980
Query: 414 YMRKLEARLEKVADEK 429
M L+ + K+ EK
Sbjct: 981 EMAGLDEIIAKLTKEK 996
Score = 37.0 bits (84), Expect = 0.053
Identities = 37/204 (18%), Positives = 90/204 (44%), Gaps = 18/204 (8%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY---------- 169
+++ ++ DL QL+ ++E V E R+ ++ ++A+ A EL ++
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1783
Query: 170 KGISRSHGEITEERDILS--------RQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
K + ++ ++ D +Q AR+ ELE++++ ++ + +
Sbjct: 1784 KNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKS 1843
Query: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
+K LT + E+ L +Q ++ + +++ K Q A+E A ++ K + EL
Sbjct: 1844 ERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Query: 282 ASAAAARDRTIAELHRSRLEVAEV 305
A D +++++ R + ++
Sbjct: 1904 DEAEERADIAESQVNKLRAKSRDI 1927
Score = 37.0 bits (84), Expect = 0.053
Identities = 43/170 (25%), Positives = 80/170 (47%), Gaps = 43/170 (25%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEG---QVTELRSRVQELERALATARQEHTELMEQYKGI 172
LQ++LDE++Q + L+G Q+ +L +RV+ELE L ++ + E + KG+
Sbjct: 1793 LQHRLDEAEQ---------IALKGGKKQLQKLEARVRELENELEAEQKRNAESV---KGM 1840
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
+S I E L+ Q + +L L+D + D+L+ VKA R+
Sbjct: 1841 RKSERRIKE----LTYQTEEDRKNLLRLQDLV--------------DKLQLKVKAYKRQA 1882
Query: 233 EKL-------LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKAT 275
E+ L + ++VQ + +++E + + Q+ +L A S+ T
Sbjct: 1883 EEAEEQANTNLSKFRKVQHELDEAEERADIAESQV---NKLRAKSRDIGT 1929
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 82.0 bits (201), Expect = 1e-15
Identities = 80/333 (24%), Positives = 152/333 (45%), Gaps = 28/333 (8%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
KA+ LQN+LD + + ++ L S++Q+ + L ++ L + +
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 172 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 231
+ + E+++ + + ++L L+ + +KV ++ L + K L ++
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 232 QEKLLGQLKE-------VQADKEQSEAELEPLKEQLRGAQELAASSQQKA----TLLGEE 280
E L +L+E ++ K + + EL+ L L +++A++ ++K LL EE
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE 1460
Query: 281 ---LASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE 337
A A RDR AE + + R E L KEE + +K+ ++ + +
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSL-ARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 338 KDKILKLSAEILR----LEKAVQEERTQNQVFKTELAREKDSSL---VQLSESKRELTEL 390
KD + K E+ + LE+ V+E RTQ + + EL +D+ L V + K +
Sbjct: 1520 KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE-- 1577
Query: 391 RSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 423
R LQ EQ +E+K+ L++ +R+LEA LE
Sbjct: 1578 ----RDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Score = 78.6 bits (192), Expect = 2e-14
Identities = 82/347 (23%), Positives = 162/347 (46%), Gaps = 33/347 (9%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+ +L + ++ R +L + K +L+G+ T+L+ ++ EL+ + + + + E+ +G
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQE 233
+ T ++ + + A+I EL++D + SEK + E + L + ++AL E E
Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQEDFE--SEKASRNKAEKQKRDLSEELEALKTELE 1156
Query: 234 KLL---GQLKEVQADKEQSEAEL-EPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
L +E++ +EQ AEL + L+E+ + + +Q+ EEL+
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
R A L +++ + N LA L++ K + +R L V+ K+ + + L
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE--GDRL 1274
Query: 350 RLEKAVQEERTQNQVFKTELARE----------KDSSLVQ---------LSESKRELTEL 390
R+E A + + QN++ E KD++ ++ L E R+ L
Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334
Query: 391 RSALRVLQKEKEQLQEEKQELLEYMRKLEARL----EKVADEKWNED 433
S +R L++EK LQE+++E E + LE ++ ++AD K D
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/367 (22%), Positives = 158/367 (43%), Gaps = 48/367 (13%)
Query: 122 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE 181
E+++ R L K +LE + +L SRV+E E + E ++ + + E
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 182 ERDILSRQQGDHVARILELEDDIQTISEK----VLTKEVELDRLRDTVKALTREQEK--- 234
R L ++ A+I ++E++I + ++ + K++ DR+ + L E+EK
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 235 ----------LLGQLKEVQADKEQSEAELEPLKEQLRG--------AQELAASSQQKATL 276
++ L+E +E++ ELE K +L G EL A +
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 277 LG---EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKERAGL 330
L EEL A A D + + V E+ ++AEL + EK + K++ L
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 331 LQSVEAEKDKI--------------LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSS 376
+ +EA K ++ K E+ L+KA++EE ++ ++ + ++
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 377 LVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATT 436
L +LSE +L + + L+K K+ L+ + +EL ++ L+ + ++ DA
Sbjct: 1205 LEELSE---QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 437 EDEEAAV 443
++ A V
Sbjct: 1262 QELHAKV 1268
Score = 70.1 bits (170), Expect = 6e-12
Identities = 68/318 (21%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L + D+ + ++L + K LE QV E+R++++ELE L L + +
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
ERD+ +R + + E+ + + ++V E EL+ R ++K+
Sbjct: 1576 F-----ERDLQTRDEQN--------EEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 295
LK+++A E + + + +QLR Q Q+ EL A A+RD A+
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-------ELEEARASRDEIFAQS 1675
Query: 296 HRSRLEVAEVNGRLAEL----------GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
S ++ + + +L H ++E+ + + E A D+ +L
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
A I +LE+ ++EE++ ++ + + +Q+ EL RSA + ++QL+
Sbjct: 1736 ARIAQLEEELEEEQSNMELLNDRFRK----TTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 406 EEKQELLEYMRKLEARLE 423
+ +EL +++LE ++
Sbjct: 1792 RQNKELKAKLQELEGAVK 1809
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/383 (21%), Positives = 162/383 (42%), Gaps = 39/383 (10%)
Query: 108 LVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELME 167
L++ + L+ +L++ +++R + K ++E + +L ++++ +A ++ +L
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQA 1652
Query: 168 QYKGISRSHGEITEERDILSRQQGDHV-------ARILELEDDIQTISEKVLTKEVELDR 220
Q K R E RD + Q + A IL+L++++ + E E D
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 221 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
L D + + LL + + ++A Q E ELE + + + + + L E
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 281 LA---SAAAARDRTIAELHRSRLEV----------------AEVNGRLAELGLHLKEEKC 321
LA SAA D +L R E+ A ++ A++G L+E+
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG-QLEEQLE 1831
Query: 322 QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----AREKDSSL 377
Q +KERA + V + K+ ++ + V++ER +K ++ AR K
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQ-------VEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 378 VQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTE 437
QL E++ E T ++ R LQ+E + E + L + L+ RL + ++ +
Sbjct: 1885 -QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGR 1943
Query: 438 DEEAAVGLSCPAALTDSEDESPE 460
+ G S + D+E ++ +
Sbjct: 1944 RQLHLEGASLELSDDDTESKTSD 1966
Score = 69.7 bits (169), Expect = 7e-12
Identities = 79/360 (21%), Positives = 164/360 (45%), Gaps = 43/360 (11%)
Query: 140 QVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILE 199
QVT +Q + L +++ T++ + + + R H ++ EE++IL+ Q + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ----LQAETE 901
Query: 200 LEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQ 259
L + + + ++ K+ EL+ + +++ E+E+ + + +Q +K++ +A ++ L+EQ
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEE---RNQILQNEKKKMQAHIQDLEEQ 958
Query: 260 L---RGAQEL----AASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAE- 311
L GA++ +++ K + EE+ + I E +AE + +LAE
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 312 --------------------LGLHL-KEEKCQWSKERAGLLQSVEAE--KDKILKLSAEI 348
L L KEEK + E+A E +D+I +L A+I
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 349 --LRLEKAVQEERTQNQVFK-TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
L+L+ A +EE Q + + + K+++L + E + ++ EL+ + + + +
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 406 EEKQELLEYMRKLEARLEKVAD--EKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMR 463
++K++L E + L+ LE D E T ++E A T + + +DMR
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Score = 60.5 bits (145), Expect = 4e-09
Identities = 81/376 (21%), Positives = 166/376 (44%), Gaps = 54/376 (14%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L QL+++++ + +L + K LE EL V+ L++ A + + +L Q +
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ---VQEL 1264
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL--------DRLRDTVKA 227
H +++E D L + + +++ D++ T+ E+ K ++ +L+DT +
Sbjct: 1265 HAKVSEG-DRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323
Query: 228 L---TREQEKLLGQLKEVQADK----EQSEAELEP---LKEQLRGAQELAASSQQK---- 273
L TR++ L ++++++ +K EQ E E E L++Q+ Q A +++K
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 274 -----------------ATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHL 316
A L + L A A D+ +R + E+ ++ L H
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD----HQ 1439
Query: 317 KEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSS 376
++ K++ Q + EK + + E R E +E+ T+ LAR + +
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK----ALSLARALEEA 1495
Query: 377 LVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV---ADEKWNED 433
L E +R+ +LR+ + L K+ + + EL + R LE ++E++ +E +E
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 434 ATTEDEEAAVGLSCPA 449
TED + + ++ A
Sbjct: 1556 QATEDAKLRLEVNMQA 1571
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 81.3 bits (199), Expect = 2e-15
Identities = 81/347 (23%), Positives = 150/347 (43%), Gaps = 32/347 (9%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
K +LQ QL + + R+ Q + + EL +V+EL+ + TARQE E Q
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 172 IS---RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
+ RS + E++ +++++ +L++ +Q + E + + L+ +
Sbjct: 676 LELQLRSEQQKATEKERVAQEKD-------QLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 229 TREQEKLLGQLK-EVQADKEQSEAELEPLKEQLRGA-------QELAASSQQKATLLGEE 280
EQ++ + +LK E ++ EQ + E + L+E+ G Q+L + Q + +L E
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
Query: 281 LASAAAARDRTIAELHRSRLEVAEVNGRL-------AELGLHLKEEKCQWSKERAGLLQS 333
LA A AA+ +E + EVA R A+ G +E+ +E Q
Sbjct: 789 LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848
Query: 334 VEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSA 393
++ K+K+ + + +Q R QN++ EL +L Q+ E + +L
Sbjct: 849 LQEAKEKVAGIES-----HSELQISRQQNEL--AELHANLARALQQVQEKEVRAQKLADD 901
Query: 394 LRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
L LQ++ +E L +RK + E + E E A D +
Sbjct: 902 LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948
Score = 77.8 bits (190), Expect = 3e-14
Identities = 78/323 (24%), Positives = 150/323 (46%), Gaps = 24/323 (7%)
Query: 114 TVLQNQLDESQQERNDLMQLK----LQLEGQVTELRSRVQELERALATARQEHTELMEQY 169
T LQ+ + Q + +L Q +L QV L S + L + QE L +Q
Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQA 528
Query: 170 KGISRSHGEITEERDILS---RQQGDHVARIL-ELEDDIQTISEKV-LTKEVELDRLRDT 224
K + ++++ S R Q + ++ L + E ++ ++EK T++ +L
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 225 VKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASA 284
+ + LK+++A +++ A+LE L++QL+ A E S+Q T E A
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKL 344
+ + A + +R E E ++AEL L L+ E +++A + V EKD
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSE-----QQKATEKERVAQEKD----- 698
Query: 345 SAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL 404
+L++ +Q + +V K L EK + L E +R ++EL++ R L ++ ++
Sbjct: 699 -----QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753
Query: 405 QEEKQELLEYMRKLEARLEKVAD 427
++E +E + LEARL+++ +
Sbjct: 754 RKELEEERAGRKGLEARLQQLGE 776
Score = 66.6 bits (161), Expect = 6e-11
Identities = 77/353 (21%), Positives = 155/353 (43%), Gaps = 34/353 (9%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATAR----QEHTELMEQYKGISR 174
QL+ +QE L QL+ +V L + + E L R +E +L +
Sbjct: 414 QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS 473
Query: 175 SHGEITEERDILSRQQGDHVAR----ILELEDDIQTISEKVLTKEVELDRLRDTVK---- 226
S +++ ++ L + H AR + L ++ T++ + ++ EL L+ K
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 227 --ALTREQEK-----LLGQLKEVQADKEQSEAELEPLKEQLRG-----AQELAASSQQKA 274
A T +Q++ L Q++++ + +Q E +L+ + E+ AQ+LA +++++
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 275 TLLGEELAS-----AAAARDRTIAELHRSRLEVAEVNGRLAELGL-HLKEEKCQWSKERA 328
L E A+ A E+ + +L+VA A+ + + EK + S++
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 329 GLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELT 388
L VE + + + A++ LE ++ E+ Q K +A+EKD QL K L
Sbjct: 654 ELQACVETARQEQHEAQAQVAELELQLRSEQ-QKATEKERVAQEKDQLQEQLQALKESLK 712
Query: 389 ELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 441
+ +L ++EK + + +E + +L+A + ++ E E+E A
Sbjct: 713 VTKGSL---EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Score = 66.2 bits (160), Expect = 8e-11
Identities = 87/400 (21%), Positives = 177/400 (44%), Gaps = 56/400 (14%)
Query: 97 LEEADGGSDILLVVPKATVLQNQ---LDESQQER--NDLMQLKLQLEGQVTELRSRVQEL 151
LEE ++ L + T+ Q Q ++SQ +R N L + L ++ E S +Q+L
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337
Query: 152 ERALATARQEHTELMEQY--------KGISRSHGE---ITEERDILSRQQGDHVARILEL 200
+ AL +EH++ +++ K +S + + + E+ +IL + + +L
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL 397
Query: 201 EDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL------- 253
+D+ +VL ++L+ L+ L +L +++ ++ ++ Q EA+L
Sbjct: 398 QDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457
Query: 254 EPLKEQLRGAQELAASSQQKATLLGEELASAAAARD-RTIAELHRSRLEVAEVNGRLAEL 312
E K+QL SS + EEL A+ A R A++ E+ +N + +
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517
Query: 313 GLHLKEEKCQWSKERAGLLQSVEAE-------KDKILKLSAEILRLEKAVQEERTQNQVF 365
L K Q +++A L Q+++ + + ++ +LS+ + + E+ ++E + +
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 366 KTELA--------------REKDSSLVQLSESKRE----LTELRSALRVLQKEKE----- 402
+ + A RE+D++L QL ++E L L+ L+V + ++
Sbjct: 578 RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTS 637
Query: 403 --QLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
Q Q EK EL + +L+A +E E+ A + E
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE 677
Score = 63.9 bits (154), Expect = 4e-10
Identities = 76/333 (22%), Positives = 147/333 (44%), Gaps = 40/333 (12%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE----HTELME 167
+A L+ L+ + R + L+GQ+ E + + ALA+A++E T++ +
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 168 QYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA 227
K ++ R R+ + I LE+++ ++ +VL KE E L+ V A
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKN----SLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 228 LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 287
+ + +KL +L+ +QA+ + +A + ++++ L EE+ S
Sbjct: 1258 ESEKSQKLEERLRLLQAETASN-----------------SARAAERSSALREEVQSLREE 1300
Query: 288 RDRTIAELHRSRLEVAEVNGRLAELGLHLK--EEKCQWSKERAGLLQSVEAEKDKILKLS 345
++ R E+ R ELG LK +EK + KE+A L +++ E L
Sbjct: 1301 AEKQRVASENLRQELTSQAERAEELGQELKAWQEKF-FQKEQA--LSTLQLEHTSTQALV 1357
Query: 346 AEILRLEKAVQ----EERTQNQVFKTELAREKDSS---LVQLSESKRELTE---LRSALR 395
+E+L + Q E+ + + EL + K ++ +L ++REL E LR +
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA 1417
Query: 396 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
++ +QL+ EK E + L+ +A+E
Sbjct: 1418 EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Score = 61.2 bits (147), Expect = 3e-09
Identities = 81/338 (23%), Positives = 144/338 (42%), Gaps = 54/338 (15%)
Query: 117 QNQLDESQQE----RNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
+ +L++S+Q R +L++ + +L G++ LR +V E ER R E EQ +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQREL-GELIPLRQKVAEQERTAQQLRAEKASYAEQLSML 1440
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
++HG + EE +R G+ + + L EVELD+ R
Sbjct: 1441 KKAHGLLAEE----NRGLGERA-----------NLGRQFL--EVELDQAR---------- 1473
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
EK + +L V+AD E AE++ +E A+EL + A A+ + +
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQ--REAQSTARELEVMT-----------AKYEGAKVKVL 1520
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
E R + E ++ ++ +L + +E+ Q + L S +A K + KL
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKL-------- 1572
Query: 353 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
KAVQ + ++Q L + + QLS+ ++ + + + + +++ QEL
Sbjct: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 413 EYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAA 450
E +R LE +L+K E E E GL A
Sbjct: 1633 EQLRSLE-QLQKENKELRAEAERLGHELQQAGLKTKEA 1669
Score = 57.8 bits (138), Expect = 3e-08
Identities = 69/323 (21%), Positives = 141/323 (43%), Gaps = 48/323 (14%)
Query: 147 RVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 206
+++ L++ LA R EL E+ E R +L+ + +A + + D +
Sbjct: 215 QMRRLKKQLADERSNRDEL----------ELELAENRKLLTEKDAQ-IAMMQQRIDRLAL 263
Query: 207 ISEKVLTKEVE---LDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRG- 262
++EK +E L+ LRD ++LT + L Q ++++ +K Q + ++ L E+
Sbjct: 264 LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDL 323
Query: 263 ---AQELAASSQQKATLLGE-------------------ELASAAAARDRTIAELHRSRL 300
+E A+ QQ L E E +AA +D+ E L
Sbjct: 324 SFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383
Query: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV---EAEKDKILKLSAEILRLEKAVQE 357
+ G+L++L HL + + +E+ +L V E K + L+A +L+ V+
Sbjct: 384 Q-----GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
Query: 358 ERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRK 417
T+ + +L E+ + + +T+L+S++ L + KE+L++ Q + +
Sbjct: 439 LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ---AHGAR 495
Query: 418 LEARLEKVADEKWNEDATTEDEE 440
L A++ + E +AT + ++
Sbjct: 496 LTAQVASLTSELTTLNATIQQQD 518
Score = 56.6 bits (135), Expect = 6e-08
Identities = 88/376 (23%), Positives = 145/376 (38%), Gaps = 65/376 (17%)
Query: 124 QQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEER 183
+Q+ + L+ E ELER A + + E+ R +T+ER
Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQER 1013
Query: 184 DILSRQQGDHVARILELEDDIQ-----------TISEKV---LT----KEVELDRLRDTV 225
A ELE +Q T+ E + LT K+ EL +LR
Sbjct: 1014 GRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073
Query: 226 KALTREQEKL---LGQLKEVQADKE---------QSEA---------ELEPLKEQLRGAQ 264
A +E E+L + QLKE A KE QSEA +LE L+ ++ +
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133
Query: 265 ELAASSQQKATLLGEELASAAAAR--------------DRTIAELHRSRLEVAEVNGRLA 310
+ Q++A L L + A+R + EL S+ +A LA
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 311 ELGLHLKEE---KCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
+++ + +W + A Q E + I L E+ L + V E+ +++ K
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 368 ELAREKDSSLVQLSESKRELTELRSALRVLQ--KEKEQLQEEKQELLEYMRKLEARLEKV 425
+ E + S Q E + L + +A + + L+EE Q L E EA ++V
Sbjct: 1254 LVMAESEKS--QKLEERLRLLQAETASNSARAAERSSALREEVQSLRE-----EAEKQRV 1306
Query: 426 ADEKWNEDATTEDEEA 441
A E ++ T++ E A
Sbjct: 1307 ASENLRQELTSQAERA 1322
Score = 55.8 bits (133), Expect = 1e-07
Identities = 106/460 (23%), Positives = 178/460 (38%), Gaps = 115/460 (25%)
Query: 109 VVPKATVLQNQLDESQQE--------RNDLMQLKLQLEGQVTELRSRVQELERALATARQ 160
+V + + + ++SQQE + LM LK + E + R +QE + +A +
Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE----KARQELQEAKEKVAGI-E 860
Query: 161 EHTELMEQYKGISRSHGEITEERDILSR---QQGDHVARILELEDDIQTISEKVLTKEVE 217
H+EL ISR E+ E L+R Q + R +L DD+ T+ EK+ E
Sbjct: 861 SHSELQ-----ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE 915
Query: 218 LDRLRDTVK--------------------------------------------ALTREQE 233
+ RL V+ A+ RE E
Sbjct: 916 VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 234 KLLGQLKEVQA-----------DKEQSEAELEPLKEQLRGAQ-ELAASSQQKATL----- 276
++ +L+ ++A ++ Q E E+ L ++ AQ +LA +A L
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 277 ------------LGEELASAAAARDRTIAELHRSR-LEVAEVNG--RLAELGLHLKEEKC 321
L E LA A ++ EL + R LE A++ L + LKE+
Sbjct: 1036 NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095
Query: 322 QWSKERAG-------LLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL----- 369
+ KE A E K+ L AE+ +LE+ Q+++ Q + L
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA 1155
Query: 370 -AREKDSSLV----QLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
E+DS+L QL E +EL +SAL Q+E + + Q+ + + +A++ +
Sbjct: 1156 SRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215
Query: 425 VADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRL 464
E +++ E V + L + E ES E RL
Sbjct: 1216 GRQEAERKNSLISSLEEEVSILNRQVL-EKEGESKELKRL 1254
Score = 54.7 bits (130), Expect = 2e-07
Identities = 72/330 (21%), Positives = 141/330 (42%), Gaps = 29/330 (8%)
Query: 140 QVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILE 199
++ ELR + + L L ++ +L + + R +++EE LS + + + + +
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 200 LEDDIQTIS-----------EKVLTKEVELDRLRDTVKALTREQEKLLGQ-------LKE 241
L+D + ++ EK E EL K L + E L G+ L +
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 242 VQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 301
+Q + Q + E+ QL ++ AA+ T L + R + A+L R
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 302 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE----KDKILKLSAEILRLEKAVQE 357
E +L+ L L+ S+ + L Q+ +A ++ L++E+ L +Q+
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516
Query: 358 ERTQNQVFKTELAREKDSSLVQLSESKRELTE-LRSALRVLQ---KEKEQLQEEKQELLE 413
+ + K + A+EK + L Q + + + ++ LR + L K+KEQ +E E E
Sbjct: 517 QDQELAGLKQQ-AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 414 YMRKLEARLEKVADEKWNEDATTEDEEAAV 443
R+ A+ A E+ +A+ + +AA+
Sbjct: 576 ATRQDHAQQLATAAEE--REASLRERDAAL 603
Score = 54.7 bits (130), Expect = 2e-07
Identities = 74/363 (20%), Positives = 156/363 (42%), Gaps = 44/363 (12%)
Query: 86 QEPRPMDELVTLEEADGGSDILLVVPKATVLQNQL----DESQQERNDLMQLKLQLEGQV 141
++ + ++E + L +A+ S+ +++ L+ ++ +E++++R L+ +L Q
Sbjct: 1260 EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQA 1319
Query: 142 TELRSRVQEL----------ERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQG 191
QEL E+AL+T + EHT E+ + + + Q
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVS-------ELLPAKHLCQQLQA 1372
Query: 192 DHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQ---LKEVQADKEQ 248
+ A ++++ + EL R + + L ++K+ Q ++++A+K
Sbjct: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKAS 1432
Query: 249 SEAELEPLK-------EQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 301
+L LK E+ RG E A +Q L EL A R++ + EL R
Sbjct: 1433 YAEQLSMLKKAHGLLAEENRGLGERANLGRQ---FLEVELDQA---REKYVQELAAVR-- 1484
Query: 302 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQ 361
A+ RLAE+ + E ++E + E K K+L+ + + + Q
Sbjct: 1485 -ADAETRLAEV----QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
Query: 362 NQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 421
+VF+ E ++ + +L++S + + L+ +Q + + Q+E Q L + +L+A+
Sbjct: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
Query: 422 LEK 424
L +
Sbjct: 1600 LSQ 1602
Score = 53.9 bits (128), Expect = 4e-07
Identities = 79/386 (20%), Positives = 157/386 (40%), Gaps = 60/386 (15%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQEL------ERALATARQEHTELMEQYKGISR 174
DE + E + +L + + Q+ ++ R+ L + A +E EL ++ + ++
Sbjct: 231 DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E ++ L ++ +I +L ++ +S K+ L +L+D + LT E K
Sbjct: 291 RLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK 350
Query: 235 LLGQL--KEVQADKEQSEA----------------ELEPLKEQLRGAQELAASSQQKATL 276
+ K+ Q +KE S A +L L+E L Q+ Q+K +
Sbjct: 351 ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD--NPPQEKGEV 408
Query: 277 LGE---------ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKER 327
LG+ E A+ AA + A + E + +L H +EEK Q S
Sbjct: 409 LGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI 468
Query: 328 AGLLQSV----EAEKD--------------KILKLSAEILRLEKAVQEERTQNQVFKTEL 369
L S+ +A+++ ++ L++E+ L +Q++ + K +
Sbjct: 469 TDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ- 527
Query: 370 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 429
A+EK + L Q + + + A + L+ + EQL ++ + ++++ + E +
Sbjct: 528 AKEKQAQLAQTLQQQEQ------ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581
Query: 430 WNEDATTEDEEAAVGLSCPAALTDSE 455
+ AT +E A AAL E
Sbjct: 582 AQQLATAAEEREASLRERDAALKQLE 607
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/227 (21%), Positives = 103/227 (45%), Gaps = 10/227 (4%)
Query: 116 LQNQLDESQQER-NDLMQLKLQLEGQVTELRSRVQELERALA--TARQE--HTELMEQYK 170
L+ +LD+++++ +L ++ E ++ E++ Q R L TA+ E +++E+ +
Sbjct: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524
Query: 171 GISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR 230
++T + + L Q + ++ EL + + ++ +L ++ +
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQ 1584
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDR 290
E ++L QL E+QA Q E E K Q+ A+ + +Q+ L E+L S ++
Sbjct: 1585 EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL----EQ 1640
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE 337
E R E + L + GL KE + Q + ++S+EA+
Sbjct: 1641 LQKENKELRAEAERLGHELQQAGLKTKEAE-QTCRHLTAQVRSLEAQ 1686
Score = 43.1 bits (100), Expect = 7e-04
Identities = 45/196 (22%), Positives = 83/196 (42%), Gaps = 18/196 (9%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
K VL+ + Q+ER L QLE E +V+EL + LA + Q ++ K
Sbjct: 1516 KVKVLEER-QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 172 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTI------------SEKVLTKEVE-- 217
+ GE +E L Q + A++ + E + ++K +E++
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 218 ---LDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKA 274
L++L+ K L E E+L +L++ +++E L Q+R + A + Q+
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694
Query: 275 TLLGEELASAAAARDR 290
LG+ + A + R
Sbjct: 1695 RDLGKFQVATDALKSR 1710
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 81.3 bits (199), Expect = 2e-15
Identities = 79/339 (23%), Positives = 152/339 (44%), Gaps = 31/339 (9%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TE 164
K + +L++ ++ +L K +LE + +EL+ + +LE LA +E
Sbjct: 920 KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979
Query: 165 LMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDT 224
L E+ G+ ++T+E+ L + + ED + ++S+ + E ++D L +
Sbjct: 980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGS 1039
Query: 225 VKA-------LTREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASS 270
++ L R + KL G LK +++ DK Q E +L+ + +
Sbjct: 1040 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDE 1099
Query: 271 QQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL 330
Q A L ++L A + EL R A+V ++L L E+ E AG
Sbjct: 1100 QVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSREL--EEISERLEEAGG 1157
Query: 331 LQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTEL 390
SV+ E +K K AE ++ + ++E Q++ L ++ S+ +L E ++ L
Sbjct: 1158 ATSVQIEMNK--KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE---QIDNL 1212
Query: 391 RSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA 426
+ + L+KEK + + E ++ +E + K +A LEKV+
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS 1251
Score = 79.0 bits (193), Expect = 1e-14
Identities = 74/324 (22%), Positives = 151/324 (46%), Gaps = 24/324 (7%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
LQ LD + RN+++++K ++EG + E+ ++ R A A+++ L K
Sbjct: 1599 LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
R++ ++ E I+ R+ A + EL ++ E EL + V+ L
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ L+ Q K++++D Q ++E+E ++ R A+E A + A ++ EEL
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKK----E 1774
Query: 289 DRTIAELHRSRLE----VAEVNGRLAEL-GLHLKEEKCQWSKERAGLLQSVEAEKDKILK 343
T A L R + + ++ RL E + LK K Q K A ++ +E E + K
Sbjct: 1775 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEA-RVRELEGELEAEQK 1833
Query: 344 LSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ 403
+AE ++ + E R + ++TE E +L++L + + +L+ ++ +++ E+
Sbjct: 1834 RNAESVKGMRK-SERRIKELTYQTE---EDKKNLLRLQDL---VDKLQLKVKAYKRQAEE 1886
Query: 404 LQEEKQELLEYMRKLEARLEKVAD 427
+E+ L RK++ L++ +
Sbjct: 1887 AEEQANTNLSKFRKVQHELDEAEE 1910
Score = 62.8 bits (151), Expect = 9e-10
Identities = 63/308 (20%), Positives = 134/308 (43%), Gaps = 20/308 (6%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGE 178
+L+E+Q+ ND + +L+ + EL +++E E ++ + +Q + + R E
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 179 ITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQ 238
+ ++ L+ + D + E+ E E + + + L++ ++
Sbjct: 1324 EGKAKNALAHA-------LQSARHDCDLLREQY---EEETEAKAELQRVLSKANSEVAQW 1373
Query: 239 LKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRS 298
+ + D Q ELE K++L AQ L +++ + + +S + R E+
Sbjct: 1374 RTKYETDAIQRTEELEEAKKKL--AQRLQ-DAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430
Query: 299 RLEVAEVNGRLAELGL---HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
++V N A L + + +W ++ +E+ + + LS E+ +L+ A
Sbjct: 1431 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY 1490
Query: 356 QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYM 415
+E + FK RE + ++S+ +L E + L+K ++QL+ EK EL +
Sbjct: 1491 EESLEHLETFK----RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSAL 1546
Query: 416 RKLEARLE 423
+ EA LE
Sbjct: 1547 EEAEASLE 1554
Score = 57.4 bits (137), Expect = 4e-08
Identities = 71/342 (20%), Positives = 147/342 (42%), Gaps = 33/342 (9%)
Query: 105 DILLVVPKATVLQNQLDESQQERNDLM-QLKLQLEGQVTELRSRVQE---LERALATARQ 160
D+++ V ++ LD+ Q+ + ++ + K + E +EL S +E L L +
Sbjct: 1429 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN 1488
Query: 161 EHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR 220
+ E +E + R + + EE L+ Q G+ + ELE + +++ +++EL
Sbjct: 1489 AYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK----VRKQLEVEKLELQS 1544
Query: 221 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELE-PLKEQLRGAQELAASSQQKATLLGE 279
+ +A +E G++ Q + Q +AE+E L E+ ++ + Q+ L
Sbjct: 1545 ALEEAEASLEHEE---GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQT 1601
Query: 280 ELASAAAARDRTI-------AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQ 332
L + +R+ + +L+ ++++ N AE +K + + L
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661
Query: 333 SVEAEKD----------KILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSE 382
+V A D + L AE+ L V++ ++ + EL + S VQL
Sbjct: 1662 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI--ETSERVQLLH 1719
Query: 383 SKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
S+ T L + + ++ + QLQ E +E ++ R E + +K
Sbjct: 1720 SQN--TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKK 1759
Score = 55.5 bits (132), Expect = 1e-07
Identities = 76/383 (19%), Positives = 153/383 (39%), Gaps = 56/383 (14%)
Query: 104 SDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHT 163
+D L + K + +++ + D L LQL+ ++ E ++R++ELE L R
Sbjct: 1073 NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARA 1132
Query: 164 ELMEQYKGISRSHGEITE--------------------------ERDI------------ 185
++ + +SR EI+E RD+
Sbjct: 1133 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 186 -LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQA 244
L ++ D VA + E D++Q + +K+ ++ E D V + + K L++V
Sbjct: 1193 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSR 1252
Query: 245 DKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 304
E E E+ + + + + K ELA ++ I++L R +L +
Sbjct: 1253 TLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Query: 305 VNGRLAELGLHLKEE---------KCQWSKERAGLL-QSVEAEKDKILKLSAEILRLEKA 354
++ +L L+EE Q ++ LL + E E + +L + +
Sbjct: 1313 ---QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 355 VQEERTQ---NQVFKTELAREKDSSLVQ-LSESKRELTELRSALRVLQKEKEQLQEEKQE 410
V + RT+ + + +TE E L Q L +++ + + + L+K K +LQ E ++
Sbjct: 1370 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 411 LLEYMRKLEARLEKVADEKWNED 433
L+ + + A + ++ N D
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFD 1452
Score = 44.3 bits (103), Expect = 3e-04
Identities = 62/319 (19%), Positives = 141/319 (44%), Gaps = 25/319 (7%)
Query: 138 EGQVTELRSRVQELERALATARQE----HTELMEQYKGISRSHGEITEER--DILSRQQG 191
EGQ + R ++L +L + HT++ + G+ E+ +ER I++R Q
Sbjct: 734 EGQFIDSRKGTEKLLSSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRDERLSRIITRMQA 792
Query: 192 DHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE----KLLGQLKEVQADKE 247
+++ +E +K++ + L ++ ++A + KL ++K + E
Sbjct: 793 QARGQLMRIE------FKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAE 846
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
+E E+ +KE+ +E S+ + L E++ S ++ ++ + + +
Sbjct: 847 -TEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
R +L + K Q + + + +E E++ +L+A+ +LE E + +
Sbjct: 906 RCDQL----IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 368 ELAR---EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
LA+ EK ++ ++ E+ L + L KEK+ LQE Q+ L+ ++ E ++
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 425 VADEKWNEDATTEDEEAAV 443
++ K + +D E ++
Sbjct: 1022 LSKSKVKLEQQVDDLEGSL 1040
Score = 38.5 bits (88), Expect = 0.018
Identities = 37/207 (17%), Positives = 91/207 (43%), Gaps = 18/207 (8%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY---------- 169
+++ ++ +DL QL+ ++E V E R+ ++ ++A+ A EL ++
Sbjct: 1726 INQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1785
Query: 170 KGISRSHGEITEERDILS--------RQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
K + ++ ++ D +Q AR+ ELE +++ ++ + +
Sbjct: 1786 KNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKS 1845
Query: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
+K LT + E+ L +Q ++ + +++ K Q A+E A ++ K + EL
Sbjct: 1846 ERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1905
Query: 282 ASAAAARDRTIAELHRSRLEVAEVNGR 308
A D +++++ R + ++ +
Sbjct: 1906 DEAEERADIAESQVNKLRAKSRDIGAK 1932
>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
Length = 446
Score = 81.3 bits (199), Expect = 2e-15
Identities = 68/265 (25%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
V F +V + YIP V CHYT +P DWIGIF+V R+Y+TF+W ++P
Sbjct: 23 VIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLN 82
Query: 75 DGSPIHTSVQFQE---PRP--------MDELVTLEEA--------DGGSDILLVVPKATV 115
+ S VQF+ P+ +DE + A + DIL+V
Sbjct: 83 NKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTT---- 138
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
Q +++E +Q +L + +L+ L+ + +++ L +QE E ++
Sbjct: 139 -QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK-KQEELETLQS------- 189
Query: 176 HGEITEERDILSRQQGDH-VARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
I ++ ++ ++Q D+ +L+L++ Q +S + + +D+L+ + +E EK
Sbjct: 190 ---INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
Query: 235 LLGQLKEVQADKEQSEAELEPLKEQ 259
L VQ D++++E +LE LK++
Sbjct: 247 L------VQGDQDKTE-QLEQLKKE 264
Score = 46.6 bits (109), Expect = 7e-05
Identities = 45/228 (19%), Positives = 99/228 (43%), Gaps = 17/228 (7%)
Query: 199 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
E E+DI V+T + E++ + K L +E ++L +Q +AEL+ +E
Sbjct: 128 ENEEDIL-----VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
Query: 259 QLRGAQ----ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
+L Q +L +++ EL + +E + + V ++ +L+
Sbjct: 183 ELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
+ E+ Q +++ L+ ++ E D + E + +K +++ Q + +T +++
Sbjct: 243 EM-EKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
Query: 375 SSLVQLSESKRELTELRSALRVLQKEKEQLQ-------EEKQELLEYM 415
+ + + + L+E LQ++KE+L+ E LL YM
Sbjct: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/143 (23%), Positives = 71/143 (49%), Gaps = 12/143 (8%)
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL---QSVEAEKDKI-------- 341
AEL + + E+ + +L L +KE+K W E L Q + +E +K+
Sbjct: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ 234
Query: 342 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 401
+LS + +EK VQ ++ + + + +L +E D + L+E +++ +L + +++ +
Sbjct: 235 AQLSTQEKEMEKLVQGDQDKTEQLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
Query: 402 EQLQEEKQELLEYMRKLEARLEK 424
+++QEL++ L RL +
Sbjct: 294 TTAMKKQQELMDENFDLSKRLSE 316
Score = 38.5 bits (88), Expect = 0.018
Identities = 29/123 (23%), Positives = 64/123 (52%), Gaps = 9/123 (7%)
Query: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 360
E+ + N L + LK+ K+ + + ++ +++++ L + +LE V+E
Sbjct: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE--- 200
Query: 361 QNQVFKTELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQL---QEEKQELLEY 414
Q ++TEL + K+ + SE+++ + +L++ L +KE E+L ++K E LE
Sbjct: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Query: 415 MRK 417
++K
Sbjct: 261 LKK 263
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 80.9 bits (198), Expect = 3e-15
Identities = 82/327 (25%), Positives = 154/327 (47%), Gaps = 24/327 (7%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
A LQ+ LD + RND ++LK ++EG + E+ ++ R +A ++ + Q K
Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS 1657
Query: 173 S-------RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTV 225
RS+ ++ E+ I+ R+ G + + E++ ++ E EL D V
Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717
Query: 226 KALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAA 285
+ L + L+ K+++AD Q +AE+E ++ R A+E A + A ++ EEL
Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK-- 1775
Query: 286 AARDRTIAELHRSRLE----VAEVNGRLAEL-GLHLKEEKCQWSKERAGLLQSVEAEKDK 340
T A L R + V ++ RL E L LK K Q K ++ +E E D
Sbjct: 1776 --EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-LENRVRELENELDV 1832
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
K AE L+ A + ER ++ T A E ++++L + + +L++ ++ +++
Sbjct: 1833 EQKRGAEALK--GAHKYERKVKEM--TYQAEEDHKNILRLQDL---VDKLQAKVKSYKRQ 1885
Query: 401 KEQLQEEKQELLEYMRKLEARLEKVAD 427
E+ +E+ L R+++ LE+ A+
Sbjct: 1886 AEEAEEQANTQLSRCRRVQHELEEAAE 1912
Score = 77.0 bits (188), Expect = 5e-14
Identities = 100/480 (20%), Positives = 205/480 (42%), Gaps = 50/480 (10%)
Query: 83 VQFQEPRPMDELVTLEEADGG--SDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQ 140
+Q Q + L+ EE G +L+ K L +L+E ++ ++L+ K LE +
Sbjct: 891 LQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950
Query: 141 VTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL 200
+ L+ + +LE L +E + K +S + E L++++ +
Sbjct: 951 CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT 1010
Query: 201 EDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE-PLKEQ 259
DD+Q +KV L ++ ++ T + E L Q K+++AD E+++ +LE LK
Sbjct: 1011 LDDLQVEEDKV----NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMS 1066
Query: 260 LRGAQELAASSQQKATLLGE---ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHL 316
+L QQ L + EL+ A D + + ++ E+ R+ EL +
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126
Query: 317 KEE---KCQWSKERAGLLQSVEAEKDKI--------------LKLSAEILRLEKAVQEER 359
+ E + + K+R+ L + +E +++ K AE ++ + ++E
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 360 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 419
Q++ L +++ S+ +L E + LQ+ K++L++EK EL + +
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQ----------IDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 420 ARLEKVADEKWNED---ATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPG 476
+ +E ++ K N + T ED+ + + A + + + D+ + L +
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEI-----KAKDEQQTQLIHDLNMQKARLQTQNGEL 1291
Query: 477 SSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDE-KSVLMAAVQSGGEEANLL 535
S +E+ +ISQ L+ E+ E E + K+ + A+QS + +LL
Sbjct: 1292 SHRVEEKES----LISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLL 1347
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/383 (20%), Positives = 156/383 (40%), Gaps = 42/383 (10%)
Query: 89 RPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRV 148
R ++E EA + L Q+D Q+ + L + K +L+ ++ ++ S +
Sbjct: 1180 RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI 1239
Query: 149 QEL-------ERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELE 201
+ L ER T + +E+ + + ++ ++ ++ L Q G+
Sbjct: 1240 EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE--------- 1290
Query: 202 DDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADK-------EQSEAELE 254
+S +V KE + +L + +ALT++ E+L Q++E K + S + +
Sbjct: 1291 -----LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCD 1345
Query: 255 PLKEQLRGAQELAASSQQKATLLGEELA-------SAAAARDRTIAELHR---SRLEVAE 304
L+EQ QE A Q+ + E+A + A R + E + RL+ AE
Sbjct: 1346 LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405
Query: 305 VNGRLAELG-LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQ 363
N A L++ K + E L++ +E L + +K + E + +
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD 1465
Query: 364 VFKTEL---AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEA 420
+ EL +E S +L + + E+ L L++E + LQEE +L E + +
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525
Query: 421 RLEKVADEKWNEDATTEDEEAAV 443
L++ K + D + A+
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVAL 1548
Score = 61.2 bits (147), Expect = 3e-09
Identities = 65/320 (20%), Positives = 146/320 (45%), Gaps = 31/320 (9%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS--- 173
+ +LDESQ E + L ++ ++R+ +E+ L T R+E+ L E+ ++
Sbjct: 1461 KQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520
Query: 174 ----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 229
++ E + + ++ +++ D + E+E ++ K+L ++EL +++ +
Sbjct: 1521 AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV 1580
Query: 230 REQEKLLGQLKE-----VQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASA 284
E+++ + QLK +A + +AE+ + LR +++ + LG
Sbjct: 1581 IEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHS---- 1636
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKL 344
+R +AE + + V G+L + LHL ++ + +++ L VE +L+
Sbjct: 1637 ----NRQMAETQK---HLRTVQGQLKDSQLHL-DDALRSNEDLKEQLAIVERRNGLLLE- 1687
Query: 345 SAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL 404
E+ ++ A+++ ++ + EL D VQL S+ T L + + L+ + Q
Sbjct: 1688 --ELEEMKVALEQTERTRRLSEQELLDASDR--VQLLHSQN--TSLINTKKKLEADIAQC 1741
Query: 405 QEEKQELLEYMRKLEARLEK 424
Q E + ++ R E + +K
Sbjct: 1742 QAEVENSIQESRNAEEKAKK 1761
Score = 57.8 bits (138), Expect = 3e-08
Identities = 74/333 (22%), Positives = 153/333 (45%), Gaps = 34/333 (10%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ +L S+ R +L + + L + +L+ +VQ L A + L++ +
Sbjct: 864 KEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKV 923
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTIS------EKVLTK--------EVELDRLR 222
E+TE + + VA+ LED ++ E LTK E ++ L
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 223 DTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL- 281
+ + AL KL + K +Q +Q+ +L+ ++++ G ++ A +Q+ L L
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 282 ------ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL----L 331
A A+ + +L S+ + ++ ++ LK+++ + S+ +A + +
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEE---RTQNQVFKTELAREKDSSLVQLSESKRELT 388
S++ +K KI +L A I LE+ ++ E R + + +++LARE L ++SE E +
Sbjct: 1104 HSLQFQK-KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE----LEEISERLEEAS 1158
Query: 389 ELRSALRVLQKEKE-QLQEEKQELLEYMRKLEA 420
SA + K++E + Q+ +++L E + EA
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Score = 53.1 bits (126), Expect = 7e-07
Identities = 74/340 (21%), Positives = 143/340 (42%), Gaps = 48/340 (14%)
Query: 129 DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSR 188
D +Q +LE +L R+QE E TA + L K R GE+ D++
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE---KTKQRLQGEV---EDLMRD 1435
Query: 189 QQGDHVARILELEDDIQTISEKVLTK--------EVELDRLRDTVKALTRE-------QE 233
+ H A D Q +KVL + + EL+ + ++L+ E E
Sbjct: 1436 LERSHTA--CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
+++ QL+ ++ + + + E+ L EQ+ + +++ L+ +E + A +
Sbjct: 1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG 1553
Query: 294 ELH-------RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSA 346
L R +LE+++V L + EE Q + +++++ D ++
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQE 406
+ LRL+K ++ + + + +QL S R++ E + LR +Q QL++
Sbjct: 1614 DALRLKKKMEGDLNEME--------------IQLGHSNRQMAETQKHLRTVQ---GQLKD 1656
Query: 407 EKQELLEYMRKLEARLEKVA-DEKWNEDATTEDEEAAVGL 445
+ L + +R E E++A E+ N E EE V L
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVAL 1696
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/155 (27%), Positives = 73/155 (47%), Gaps = 9/155 (5%)
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEA-- 336
+E+A+ +RT EL RS E+ ++ L + + Q E L+ + E
Sbjct: 851 KEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 337 --EKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL 394
K KIL L A++ L + ++EE N +EL +K + + S KR++ +L L
Sbjct: 911 GLIKSKIL-LEAKVKELTERLEEEEEMN----SELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 395 RVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 429
++KEK + + + L E M LE + K+ EK
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
Score = 33.9 bits (76), Expect = 0.44
Identities = 41/168 (24%), Positives = 73/168 (43%), Gaps = 33/168 (19%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEG---QVTELRSRVQELERALATARQEHTELMEQYKGI 172
LQ++LDE++Q L L+G Q+ +L +RV+ELE L ++ E ++
Sbjct: 1797 LQHRLDEAEQ---------LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY 1847
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
R E+T + + DH IL L+D + D+L+ VK+ R+
Sbjct: 1848 ERKVKEMTYQAE------EDH-KNILRLQDLV--------------DKLQAKVKSYKRQA 1886
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
E+ Q + + + ELE E+ A+ + K+ +G +
Sbjct: 1887 EEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
Score = 30.4 bits (67), Expect = 4.9
Identities = 25/132 (18%), Positives = 57/132 (43%), Gaps = 7/132 (5%)
Query: 91 MDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQE 150
+DE L G I + + L+N+LD Q+ + ++ + E +V E+ + +E
Sbjct: 1801 LDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEE 1860
Query: 151 LERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEK 210
+ + + +L + K R E E Q ++R ++ +++ +E+
Sbjct: 1861 DHKNILRLQDLVDKLQAKVKSYKRQAEEAEE-------QANTQLSRCRRVQHELEEAAER 1913
Query: 211 VLTKEVELDRLR 222
E ++++LR
Sbjct: 1914 ADIAESQVNKLR 1925
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 80.1 bits (196), Expect = 5e-15
Identities = 82/351 (23%), Positives = 160/351 (45%), Gaps = 15/351 (4%)
Query: 97 LEEADGGSDILLVVPK--ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA 154
LE+ D LL K ++ ++ D ++ E + L L + E +ELER
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 155 LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTK 214
+ E +L+ + ++ E+ + + L Q + ++ ELED++Q + L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 215 EVELDRLRDTVKA-LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQK 273
EV + L+ + L E+ + +++Q + E ELE ++Q A AA + +
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR--ALAAAAKKKLE 1623
Query: 274 ATLLGEELA--SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
L EL SA R+ I +L + + ++ + L + ++E +KE
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKA 1682
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
+S+EA+ +++L ++ E+A R Q + K ELA E SSL + + E L
Sbjct: 1683 KSLEAD---LMQLQEDLAAAERA----RKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 442
+ + L++E E+ Q + + + +RK + E++++E E +T + E+A
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/411 (22%), Positives = 178/411 (43%), Gaps = 88/411 (21%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA--------------LAT 157
K LQ + Q+ N+L +L+ Q Q+TE ++ +QE +A LA
Sbjct: 857 KEDELQKTKERQQKAENELKELE-QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 158 ARQEHTELMEQY------------------KGISRSHGEITEE-------RDILSRQQGD 192
+QE E++ + K +++ ++ E+ R L ++
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 193 HVARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQEK-------------L 235
A+I +LED+I + ++ L+KE +L +R+ D L E+EK +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRG-----------AQELAASSQQKATLLGEELASA 284
+ +L+ +E+S ELE LK +L G Q A + + EEL +A
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKI 341
A D IA+ + + ++ E+ G +++L L E+ + K++ L + +EA K ++
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 342 --------------LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREL 387
K E+ L+KA+ EE ++ E+ ++ ++ +L+E +L
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QL 1212
Query: 388 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 438
+ + A L K K+ L++E +L +R L ++V +K +A ++
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/382 (21%), Positives = 175/382 (45%), Gaps = 32/382 (8%)
Query: 92 DELVTLEEADG--GSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ 149
DE++ +++ + + L+ + + L L E +++ +L +LK + E ++EL R++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 150 ELERALATARQEHTELMEQYKG--------ISRSHGEITEERDILSRQQGDHVARILELE 201
+ E++ RQE +L + +G I+ +I E + L++++ + A + L+
Sbjct: 1045 KEEKS----RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 202 DDI---QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
D+I +K+ E + L++ + + + K Q +++ + E + ELE +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 259 QLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE-VAEVNGRLAEL---GL 314
QEL A +Q+ T+L + L + + + E+ + + V E+ +L +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 315 HLKEEKCQWSKERAGLL-------QSVEAEKDKILKLSAEILRLE-KAVQEERTQNQVFK 366
+L + K KE A L Q+ + + K KL A++ L+ K ER + ++
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 367 T--ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+L E +S L+E++ + +L + L + + QE QE + +L +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 425 VADEKWN-EDATTEDEEAAVGL 445
+ +E+ + +D E+ EA L
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNL 1362
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/329 (20%), Positives = 143/329 (43%), Gaps = 36/329 (10%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE-------VELDRLRDTVKALT 229
+ RD + ++ + LE D+ + E + E +E + L + + +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ L + + ++A Q E ELE + + + + Q+A L ELA+ +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----E 1776
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1824
Query: 350 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 398
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1825 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 399 KEKEQLQEEKQELLEYMRKLEARLEKVAD 427
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/413 (20%), Positives = 185/413 (44%), Gaps = 56/413 (13%)
Query: 82 SVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQ----LKLQL 137
S Q Q+ + + + T ++ + + + + + LQ+QLDE + + +L + L +QL
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 138 EGQVTELR---SRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
+L+ S V+ LE ++E L +QY+ + ++ ++ + ++ L ++ D
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD-- 1431
Query: 195 ARILELEDDIQTISEKVLTKEVELDRL--------------RDTVKALTREQEKLLGQLK 240
+++L++ Q +S + K+ + D+L RD +A RE+E L
Sbjct: 1432 -LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
+ +++ ELE + L+ E SS+ EL + A + + E+ +++L
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQL 1548
Query: 301 EVAEVNGRLAE-----LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
E E + E L ++++ K Q+ ++ L E ++K +L ++ E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 356 QEERTQNQVFKT----------ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
++ER Q + +L + DS++ E+ ++L +L++ ++ Q+E E +
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 406 EEKQELL-------EYMRKLEARL-----EKVADEKWNEDATTEDEEAAVGLS 446
+ E+ + + LEA L + A E+ + A E EE A L+
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Score = 63.9 bits (154), Expect = 4e-10
Identities = 75/337 (22%), Positives = 159/337 (47%), Gaps = 39/337 (11%)
Query: 135 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQ----L 896
Query: 195 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE 254
EL + + + ++ K+ EL+ + ++A E+E QL+ + Q +LE
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 255 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
E+ A++ + A ++L D +L + R + E R+++L
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTT 1013
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
+L EE +E+A L ++ + + + +S +RL+K EE+++ ++ K + E D
Sbjct: 1014 NLAEE-----EEKAKNLTKLKNKHESM--ISELEVRLKK---EEKSRQELEKLKRKLEGD 1063
Query: 375 SS--LVQLSESKRELTELRSALRVLQKEKEQLQ----------EEKQELLEYMRKLEARL 422
+S Q+++ + ++ EL+ L K++E+LQ +K L+ +R+LE +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 423 EKVADEKWNEDAT---TEDEEAAVGLSCPAALTDSED 456
+ ++ +E A E ++ +G A T+ ED
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/286 (20%), Positives = 130/286 (45%), Gaps = 21/286 (7%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1770
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 296
+L ++ +++E+ + L+ Q + EL + + + + S AA + IA+L
Sbjct: 1771 NELATERSTAQKNESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 297 ----RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
+ E L + LKE Q ER + E K++ K +A + +L+
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVKQLK 1883
Query: 353 KAVQEERTQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 395
+ ++E ++Q + +L RE D + RE+ L+S LR
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 14/210 (6%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE---LASAAAARDR 290
K L Q+ + + + E EL+ KE+ + A+ +QK + L EE L A
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 350
AE R+ +A L E+ LH E + + ++R Q ++AE+ K++ ++L
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERK---KMAQQMLD 954
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
LE+ ++EE Q +L EK ++ ++ + + E+ + L KE++ L+E +
Sbjct: 955 LEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 411 LLEYMRKLEARLEKVADEKWNEDATTEDEE 440
L + + E + + + K ++ + E
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Score = 36.6 bits (83), Expect = 0.069
Identities = 48/196 (24%), Positives = 83/196 (42%), Gaps = 34/196 (17%)
Query: 97 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 149
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1802
Query: 150 ELERA--------LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVAR--ILE 199
E+E A +A + +L EQ + +R T+ S +Q D + +L+
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-----SLKQKDKKLKEILLQ 1857
Query: 200 LEDDIQTISE----------KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQS 249
+ED+ + + +V + +L+ + + + + KL +L E E
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 250 EAELEPLKEQLRGAQE 265
E+ LK +LR E
Sbjct: 1918 GREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 80.1 bits (196), Expect = 5e-15
Identities = 82/351 (23%), Positives = 160/351 (45%), Gaps = 15/351 (4%)
Query: 97 LEEADGGSDILLVVPK--ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA 154
LE+ D LL K ++ ++ D ++ E + L L + E +ELER
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 155 LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTK 214
+ E +L+ + ++ E+ + + L Q + ++ ELED++Q + L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 215 EVELDRLRDTVKA-LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQK 273
EV + L+ + L E+ + +++Q + E ELE ++Q A AA + +
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR--ALAAAAKKKLE 1630
Query: 274 ATLLGEELA--SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
L EL SA R+ I +L + + ++ + L + ++E +KE
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKA 1689
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
+S+EA+ +++L ++ E+A R Q + K ELA E SSL + + E L
Sbjct: 1690 KSLEAD---LMQLQEDLAAAERA----RKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 442
+ + L++E E+ Q + + + +RK + E++++E E +T + E+A
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/411 (22%), Positives = 178/411 (43%), Gaps = 88/411 (21%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA--------------LAT 157
K LQ + Q+ N+L +L+ Q Q+TE ++ +QE +A LA
Sbjct: 864 KEDELQKTKERQQKAENELKELE-QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 158 ARQEHTELMEQY------------------KGISRSHGEITEE-------RDILSRQQGD 192
+QE E++ + K +++ ++ E+ R L ++
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 193 HVARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQEK-------------L 235
A+I +LED+I + ++ L+KE +L +R+ D L E+EK +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRG-----------AQELAASSQQKATLLGEELASA 284
+ +L+ +E+S ELE LK +L G Q A + + EEL +A
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKI 341
A D IA+ + + ++ E+ G +++L L E+ + K++ L + +EA K ++
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 342 --------------LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREL 387
K E+ L+KA+ EE ++ E+ ++ ++ +L+E +L
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QL 1219
Query: 388 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 438
+ + A L K K+ L++E +L +R L ++V +K +A ++
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/382 (21%), Positives = 175/382 (45%), Gaps = 32/382 (8%)
Query: 92 DELVTLEEADG--GSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ 149
DE++ +++ + + L+ + + L L E +++ +L +LK + E ++EL R++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 150 ELERALATARQEHTELMEQYKG--------ISRSHGEITEERDILSRQQGDHVARILELE 201
+ E++ RQE +L + +G I+ +I E + L++++ + A + L+
Sbjct: 1052 KEEKS----RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 202 DDI---QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
D+I +K+ E + L++ + + + K Q +++ + E + ELE +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 259 QLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE-VAEVNGRLAEL---GL 314
QEL A +Q+ T+L + L + + + E+ + + V E+ +L +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 315 HLKEEKCQWSKERAGLL-------QSVEAEKDKILKLSAEILRLE-KAVQEERTQNQVFK 366
+L + K KE A L Q+ + + K KL A++ L+ K ER + ++
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 367 T--ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+L E +S L+E++ + +L + L + + QE QE + +L +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 425 VADEKWN-EDATTEDEEAAVGL 445
+ +E+ + +D E+ EA L
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNL 1369
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/329 (20%), Positives = 143/329 (43%), Gaps = 36/329 (10%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE-------VELDRLRDTVKALT 229
+ RD + ++ + LE D+ + E + E +E + L + + +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ L + + ++A Q E ELE + + + + Q+A L ELA+ +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----E 1783
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1831
Query: 350 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 398
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1832 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 399 KEKEQLQEEKQELLEYMRKLEARLEKVAD 427
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/413 (20%), Positives = 185/413 (44%), Gaps = 56/413 (13%)
Query: 82 SVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQ----LKLQL 137
S Q Q+ + + + T ++ + + + + + LQ+QLDE + + +L + L +QL
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 138 EGQVTELR---SRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
+L+ S V+ LE ++E L +QY+ + ++ ++ + ++ L ++ D
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD-- 1438
Query: 195 ARILELEDDIQTISEKVLTKEVELDRL--------------RDTVKALTREQEKLLGQLK 240
+++L++ Q +S + K+ + D+L RD +A RE+E L
Sbjct: 1439 -LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
+ +++ ELE + L+ E SS+ EL + A + + E+ +++L
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQL 1555
Query: 301 EVAEVNGRLAE-----LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
E E + E L ++++ K Q+ ++ L E ++K +L ++ E +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 356 QEERTQNQVFKT----------ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
++ER Q + +L + DS++ E+ ++L +L++ ++ Q+E E +
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 406 EEKQELL-------EYMRKLEARL-----EKVADEKWNEDATTEDEEAAVGLS 446
+ E+ + + LEA L + A E+ + A E EE A L+
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Score = 63.9 bits (154), Expect = 4e-10
Identities = 75/337 (22%), Positives = 159/337 (47%), Gaps = 39/337 (11%)
Query: 135 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQ----L 903
Query: 195 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE 254
EL + + + ++ K+ EL+ + ++A E+E QL+ + Q +LE
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 255 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
E+ A++ + A ++L D +L + R + E R+++L
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTT 1020
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
+L EE +E+A L ++ + + + +S +RL+K EE+++ ++ K + E D
Sbjct: 1021 NLAEE-----EEKAKNLTKLKNKHESM--ISELEVRLKK---EEKSRQELEKLKRKLEGD 1070
Query: 375 SS--LVQLSESKRELTELRSALRVLQKEKEQLQ----------EEKQELLEYMRKLEARL 422
+S Q+++ + ++ EL+ L K++E+LQ +K L+ +R+LE +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 423 EKVADEKWNEDAT---TEDEEAAVGLSCPAALTDSED 456
+ ++ +E A E ++ +G A T+ ED
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/286 (20%), Positives = 130/286 (45%), Gaps = 21/286 (7%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1777
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 296
+L ++ +++E+ + L+ Q + EL + + + + S AA + IA+L
Sbjct: 1778 NELATERSTAQKNESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 297 ----RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
+ E L + LKE Q ER + E K++ K +A + +L+
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVKQLK 1890
Query: 353 KAVQEERTQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 395
+ ++E ++Q + +L RE D + RE+ L+S LR
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 14/210 (6%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE---LASAAAARDR 290
K L Q+ + + + E EL+ KE+ + A+ +QK + L EE L A
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 350
AE R+ +A L E+ LH E + + ++R Q ++AE+ K++ ++L
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERK---KMAQQMLD 961
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
LE+ ++EE Q +L EK ++ ++ + + E+ + L KE++ L+E +
Sbjct: 962 LEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 411 LLEYMRKLEARLEKVADEKWNEDATTEDEE 440
L + + E + + + K ++ + E
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Score = 36.6 bits (83), Expect = 0.069
Identities = 48/196 (24%), Positives = 83/196 (42%), Gaps = 34/196 (17%)
Query: 97 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 149
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1809
Query: 150 ELERA--------LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVAR--ILE 199
E+E A +A + +L EQ + +R T+ S +Q D + +L+
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-----SLKQKDKKLKEILLQ 1864
Query: 200 LEDDIQTISE----------KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQS 249
+ED+ + + +V + +L+ + + + + KL +L E E
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 250 EAELEPLKEQLRGAQE 265
E+ LK +LR E
Sbjct: 1925 GREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 80.1 bits (196), Expect = 5e-15
Identities = 82/351 (23%), Positives = 160/351 (45%), Gaps = 15/351 (4%)
Query: 97 LEEADGGSDILLVVPK--ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA 154
LE+ D LL K ++ ++ D ++ E + L L + E +ELER
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 155 LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTK 214
+ E +L+ + ++ E+ + + L Q + ++ ELED++Q + L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 215 EVELDRLRDTVKA-LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQK 273
EV + L+ + L E+ + +++Q + E ELE ++Q A AA + +
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR--ALAAAAKKKLE 1630
Query: 274 ATLLGEELA--SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
L EL SA R+ I +L + + ++ + L + ++E +KE
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKA 1689
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
+S+EA+ +++L ++ E+A R Q + K ELA E SSL + + E L
Sbjct: 1690 KSLEAD---LMQLQEDLAAAERA----RKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 442
+ + L++E E+ Q + + + +RK + E++++E E +T + E+A
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/411 (22%), Positives = 178/411 (43%), Gaps = 88/411 (21%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA--------------LAT 157
K LQ + Q+ N+L +L+ Q Q+TE ++ +QE +A LA
Sbjct: 864 KEDELQKTKERQQKAENELKELE-QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 158 ARQEHTELMEQY------------------KGISRSHGEITEE-------RDILSRQQGD 192
+QE E++ + K +++ ++ E+ R L ++
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 193 HVARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQEK-------------L 235
A+I +LED+I + ++ L+KE +L +R+ D L E+EK +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRG-----------AQELAASSQQKATLLGEELASA 284
+ +L+ +E+S ELE LK +L G Q A + + EEL +A
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKI 341
A D IA+ + + ++ E+ G +++L L E+ + K++ L + +EA K ++
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 342 --------------LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREL 387
K E+ L+KA+ EE ++ E+ ++ ++ +L+E +L
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QL 1219
Query: 388 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 438
+ + A L K K+ L++E +L +R L ++V +K +A ++
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/382 (21%), Positives = 175/382 (45%), Gaps = 32/382 (8%)
Query: 92 DELVTLEEADG--GSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ 149
DE++ +++ + + L+ + + L L E +++ +L +LK + E ++EL R++
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 150 ELERALATARQEHTELMEQYKG--------ISRSHGEITEERDILSRQQGDHVARILELE 201
+ E++ RQE +L + +G I+ +I E + L++++ + A + L+
Sbjct: 1052 KEEKS----RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 202 DDI---QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
D+I +K+ E + L++ + + + K Q +++ + E + ELE +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 259 QLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE-VAEVNGRLAEL---GL 314
QEL A +Q+ T+L + L + + + E+ + + V E+ +L +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 315 HLKEEKCQWSKERAGLL-------QSVEAEKDKILKLSAEILRLE-KAVQEERTQNQVFK 366
+L + K KE A L Q+ + + K KL A++ L+ K ER + ++
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 367 T--ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+L E +S L+E++ + +L + L + + QE QE + +L +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 425 VADEKWN-EDATTEDEEAAVGL 445
+ +E+ + +D E+ EA L
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNL 1369
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/329 (20%), Positives = 143/329 (43%), Gaps = 36/329 (10%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE-------VELDRLRDTVKALT 229
+ RD + ++ + LE D+ + E + E +E + L + + +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ L + + ++A Q E ELE + + + + Q+A L ELA+ +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----E 1783
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1831
Query: 350 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 398
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1832 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 399 KEKEQLQEEKQELLEYMRKLEARLEKVAD 427
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/413 (20%), Positives = 185/413 (44%), Gaps = 56/413 (13%)
Query: 82 SVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQ----LKLQL 137
S Q Q+ + + + T ++ + + + + + LQ+QLDE + + +L + L +QL
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 138 EGQVTELR---SRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
+L+ S V+ LE ++E L +QY+ + ++ ++ + ++ L ++ D
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD-- 1438
Query: 195 ARILELEDDIQTISEKVLTKEVELDRL--------------RDTVKALTREQEKLLGQLK 240
+++L++ Q +S + K+ + D+L RD +A RE+E L
Sbjct: 1439 -LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
+ +++ ELE + L+ E SS+ EL + A + + E+ +++L
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQL 1555
Query: 301 EVAEVNGRLAE-----LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
E E + E L ++++ K Q+ ++ L E ++K +L ++ E +
Sbjct: 1556 EELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 356 QEERTQNQVFKT----------ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
++ER Q + +L + DS++ E+ ++L +L++ ++ Q+E E +
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 406 EEKQELL-------EYMRKLEARL-----EKVADEKWNEDATTEDEEAAVGLS 446
+ E+ + + LEA L + A E+ + A E EE A L+
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Score = 63.9 bits (154), Expect = 4e-10
Identities = 75/337 (22%), Positives = 159/337 (47%), Gaps = 39/337 (11%)
Query: 135 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q +
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQ----L 903
Query: 195 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE 254
EL + + + ++ K+ EL+ + ++A E+E QL+ + Q +LE
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 255 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
E+ A++ + A ++L D +L + R + E R+++L
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTT 1020
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
+L EE +E+A L ++ + + + +S +RL+K EE+++ ++ K + E D
Sbjct: 1021 NLAEE-----EEKAKNLTKLKNKHESM--ISELEVRLKK---EEKSRQELEKLKRKLEGD 1070
Query: 375 SS--LVQLSESKRELTELRSALRVLQKEKEQLQ----------EEKQELLEYMRKLEARL 422
+S Q+++ + ++ EL+ L K++E+LQ +K L+ +R+LE +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 423 EKVADEKWNEDAT---TEDEEAAVGLSCPAALTDSED 456
+ ++ +E A E ++ +G A T+ ED
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/286 (20%), Positives = 130/286 (45%), Gaps = 21/286 (7%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1777
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 296
+L ++ +++E+ + L+ Q + EL + + + + S AA + IA+L
Sbjct: 1778 NELATERSTAQKNESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 297 ----RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
+ E L + LKE Q ER + E K++ K +A + +L+
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVKQLK 1890
Query: 353 KAVQEERTQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 395
+ ++E ++Q + +L RE D + RE+ L+S LR
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 14/210 (6%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE---LASAAAARDR 290
K L Q+ + + + E EL+ KE+ + A+ +QK + L EE L A
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 350
AE R+ +A L E+ LH E + + ++R Q ++AE+ K++ ++L
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERK---KMAQQMLD 961
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
LE+ ++EE Q +L EK ++ ++ + + E+ + L KE++ L+E +
Sbjct: 962 LEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 411 LLEYMRKLEARLEKVADEKWNEDATTEDEE 440
L + + E + + + K ++ + E
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Score = 37.7 bits (86), Expect = 0.031
Identities = 48/193 (24%), Positives = 83/193 (43%), Gaps = 34/193 (17%)
Query: 97 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 149
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1809
Query: 150 ELERA--------LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVAR--ILE 199
E+E A +A + +L EQ + +R T+ S +Q D + +L+
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-----SLKQKDKKLKEILLQ 1864
Query: 200 LEDDIQTISE----------KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQS 249
+ED+ + + +V + +L+ + + + + KL +L E E
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 250 EAELEPLKEQLRG 262
E+ LK +LRG
Sbjct: 1925 GREVNALKSKLRG 1937
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 80.1 bits (196), Expect = 5e-15
Identities = 82/351 (23%), Positives = 160/351 (45%), Gaps = 15/351 (4%)
Query: 97 LEEADGGSDILLVVPK--ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA 154
LE+ D LL K ++ ++ D ++ E + L L + E +ELER
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 155 LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTK 214
+ E +L+ + ++ E+ + + L Q + ++ ELED++Q + L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 215 EVELDRLRDTVKA-LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQK 273
EV + L+ + L E+ + +++Q + E ELE ++Q A AA + +
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR--ALAAAAKKKLE 1623
Query: 274 ATLLGEELA--SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
L EL SA R+ I +L + + ++ + L + ++E +KE
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS-RDEIFATAKENEKKA 1682
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
+S+EA+ +++L ++ E+A R Q + K ELA E SSL + + E L
Sbjct: 1683 KSLEAD---LMQLQEDLAAAERA----RKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 442
+ + L++E E+ Q + + + +RK + E++++E E +T + E+A
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/411 (22%), Positives = 178/411 (43%), Gaps = 88/411 (21%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA--------------LAT 157
K LQ + Q+ N+L +L+ Q Q+TE ++ +QE +A LA
Sbjct: 857 KEDELQKTKERQQKAENELKELE-QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 158 ARQEHTELMEQY------------------KGISRSHGEITEE-------RDILSRQQGD 192
+QE E++ + K +++ ++ E+ R L ++
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 193 HVARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQEK-------------L 235
A+I +LED+I + ++ L+KE +L +R+ D L E+EK +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRG-----------AQELAASSQQKATLLGEELASA 284
+ +L+ +E+S ELE LK +L G Q A + + EEL +A
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 285 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKI 341
A D IA+ + + ++ E+ G +++L L E+ + K++ L + +EA K ++
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 342 --------------LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREL 387
K E+ L+KA+ EE ++ E+ ++ ++ +L+E +L
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE---QL 1212
Query: 388 TELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 438
+ + A L K K+ L++E +L +R L ++V +K +A ++
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263
Score = 70.1 bits (170), Expect = 6e-12
Identities = 81/382 (21%), Positives = 175/382 (45%), Gaps = 32/382 (8%)
Query: 92 DELVTLEEADG--GSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQ 149
DE++ +++ + + L+ + + L L E +++ +L +LK + E ++EL R++
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 150 ELERALATARQEHTELMEQYKG--------ISRSHGEITEERDILSRQQGDHVARILELE 201
+ E++ RQE +L + +G I+ +I E + L++++ + A + L+
Sbjct: 1045 KEEKS----RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 202 DDI---QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
D+I +K+ E + L++ + + + K Q +++ + E + ELE +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 259 QLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE-VAEVNGRLAEL---GL 314
QEL A +Q+ T+L + L + + + E+ + + V E+ +L +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 315 HLKEEKCQWSKERAGLL-------QSVEAEKDKILKLSAEILRLE-KAVQEERTQNQVFK 366
+L + K KE A L Q+ + + K KL A++ L+ K ER + ++
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 367 T--ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+L E +S L+E++ + +L + L + + QE QE + +L +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 425 VADEKWN-EDATTEDEEAAVGL 445
+ +E+ + +D E+ EA L
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNL 1362
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/329 (20%), Positives = 143/329 (43%), Gaps = 36/329 (10%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ +L++ +++R K +LEG + +L + + A ++ +L Q K R
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE-------VELDRLRDTVKALT 229
+ RD + ++ + LE D+ + E + E +E + L + + +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ L + + ++A Q E ELE + + + + Q+A L ELA+ +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----E 1776
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
R+ A+ + S + E + LH E G ++S K I L A+I
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLH----------EMEGAVKS--KFKSTIAALEAKIA 1824
Query: 350 RLEKAVQEERTQNQVFKTELAREKDSSLVQL---SESKRELTEL--------RSALRVLQ 398
+LE+ V++E + Q T+ ++KD L ++ E +R++ E + ++ L+
Sbjct: 1825 QLEEQVEQEAREKQA-ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 399 KEKEQLQEEKQELLEYMRKLEARLEKVAD 427
++ E+ +EE Q + RKL+ L++ +
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/413 (20%), Positives = 185/413 (44%), Gaps = 56/413 (13%)
Query: 82 SVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQ----LKLQL 137
S Q Q+ + + + T ++ + + + + + LQ+QLDE + + +L + L +QL
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 138 EGQVTELR---SRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
+L+ S V+ LE ++E L +QY+ + ++ ++ + ++ L ++ D
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD-- 1431
Query: 195 ARILELEDDIQTISEKVLTKEVELDRL--------------RDTVKALTREQEKLLGQLK 240
+++L++ Q +S + K+ + D+L RD +A RE+E L
Sbjct: 1432 -LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
+ +++ ELE + L+ E SS+ EL + A + + E+ +++L
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQL 1548
Query: 301 EVAEVNGRLAE-----LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
E E + E L ++++ K Q+ ++ L E ++K +L ++ E +
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 356 QEERTQNQVFKT----------ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
++ER Q + +L + DS++ E+ ++L +L++ ++ Q+E E +
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 406 EEKQELL-------EYMRKLEARL-----EKVADEKWNEDATTEDEEAAVGLS 446
+ E+ + + LEA L + A E+ + A E EE A L+
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Score = 63.9 bits (154), Expect = 4e-10
Identities = 75/337 (22%), Positives = 159/337 (47%), Gaps = 39/337 (11%)
Query: 135 LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHV 194
LQ+ Q E++++ EL++ ++ EL E + + H ++TEE+++L Q +
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKE----LEQKHSQLTEEKNLLQEQ----L 896
Query: 195 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE 254
EL + + + ++ K+ EL+ + ++A E+E QL+ + Q +LE
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 255 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
E+ A++ + A ++L D +L + R + E R+++L
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTT 1013
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
+L EE +E+A L ++ + + + +S +RL+K EE+++ ++ K + E D
Sbjct: 1014 NLAEE-----EEKAKNLTKLKNKHESM--ISELEVRLKK---EEKSRQELEKLKRKLEGD 1063
Query: 375 SS--LVQLSESKRELTELRSALRVLQKEKEQLQ----------EEKQELLEYMRKLEARL 422
+S Q+++ + ++ EL+ L K++E+LQ +K L+ +R+LE +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 423 EKVADEKWNEDAT---TEDEEAAVGLSCPAALTDSED 456
+ ++ +E A E ++ +G A T+ ED
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/286 (20%), Positives = 130/286 (45%), Gaps = 21/286 (7%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L++++ R+++ + E + L + + +L+ LA A + + + + ++
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
R+ L ++ ARI +LE++++ ++ ++ + D V+ T++ E+L
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEE-------EQGNMEAMSDRVRKATQQAEQLS 1770
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 296
+L ++ +++E+ + L+ Q + EL + + + + S AA + IA+L
Sbjct: 1771 NELATERSTAQKNESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 297 ----RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
+ E L + LKE Q ER + E K++ K +A + +L+
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVKQLK 1883
Query: 353 KAVQEERTQNQVF---KTELAREKDSSLVQLSESKRELTELRSALR 395
+ ++E ++Q + +L RE D + RE+ L+S LR
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 50.4 bits (119), Expect = 5e-06
Identities = 49/210 (23%), Positives = 97/210 (46%), Gaps = 14/210 (6%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE---LASAAAARDR 290
K L Q+ + + + E EL+ KE+ + A+ +QK + L EE L A
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 291 TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 350
AE R+ +A L E+ LH E + + ++R Q ++AE+ K++ ++L
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDRG---QQLQAERK---KMAQQMLD 954
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
LE+ ++EE Q +L EK ++ ++ + + E+ + L KE++ L+E +
Sbjct: 955 LEEQLEEEEAARQ----KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 411 LLEYMRKLEARLEKVADEKWNEDATTEDEE 440
L + + E + + + K ++ + E
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Score = 37.7 bits (86), Expect = 0.031
Identities = 48/193 (24%), Positives = 83/193 (43%), Gaps = 34/193 (17%)
Query: 97 LEEADGGSDILLV-VPKATVLQNQL------DESQQERNDLMQLKLQLEGQVTELRSRVQ 149
LEE G + + V KAT QL + S ++N+ + QLE Q ELRS++
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE--SARQQLERQNKELRSKLH 1802
Query: 150 ELERA--------LATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVAR--ILE 199
E+E A +A + +L EQ + +R T+ S +Q D + +L+
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK-----SLKQKDKKLKEILLQ 1857
Query: 200 LEDDIQTISE----------KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQS 249
+ED+ + + +V + +L+ + + + + KL +L E E
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 250 EAELEPLKEQLRG 262
E+ LK +LRG
Sbjct: 1918 GREVNALKSKLRG 1930
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 79.7 bits (195), Expect = 7e-15
Identities = 80/305 (26%), Positives = 130/305 (42%), Gaps = 36/305 (11%)
Query: 129 DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSR 188
D + LQ E EL R QE L A Q+ L K + E+ I
Sbjct: 1465 DAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL--------EQHKIKQE 1516
Query: 189 QQGDHVARILELED-DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 247
+ + +I+ +D D Q +S+K EL +L+ ++ R ++ L LKE + +
Sbjct: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQ 1576
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
AELE LK Q+ S QQ+ +L +L ELH + + +
Sbjct: 1577 AKRAELEKLKSQV-------TSQQQEMAVLDRQLGHKKE-------ELHLLQGSMVQAKA 1622
Query: 308 RLAE---LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQV 364
L E LG EKC +E LL+ + +K + L + E +TQ +
Sbjct: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGE----------LNVQISERKTQLTL 1672
Query: 365 FKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
K E+ +E+++ V L + + TEL++ L +LQ E +LQ K + + + +LE
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVA 1732
Query: 425 VADEK 429
V +EK
Sbjct: 1733 VLEEK 1737
Score = 71.2 bits (173), Expect = 3e-12
Identities = 106/459 (23%), Positives = 190/459 (41%), Gaps = 49/459 (10%)
Query: 114 TVLQNQLDESQQERNDLMQLKLQLEGQVTELR-------SRVQELERALATARQEHTELM 166
T L+N LD Q E ++L LKLQ + +V+EL ELE ++Q+ E+
Sbjct: 1696 TELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIE 1755
Query: 167 EQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQ---TISEKVL--TKEV----- 216
Q + + R EI E SR V + + ++D+Q I EK L TK V
Sbjct: 1756 WQKQLLERDKREI-ERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAE 1814
Query: 217 --------ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAA 268
L++L V+ L +E ++L + D + +L+ +E + QE A
Sbjct: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELA 1874
Query: 269 SSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERA 328
+ Q L ++L +D ++E R + +++E R + KEE+ + ++
Sbjct: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC---QKEEETK-QQQLQ 1930
Query: 329 GLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELT 388
L +E K K+++ RL+K + E ++ + K L ++ +L++ K +L
Sbjct: 1931 VLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLD 1990
Query: 389 ELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCP 448
++ S + ++ LQEE++ + LE L + + +E E+ V S
Sbjct: 1991 QVLSKVLAAEERVRTLQEEER----WCESLEKTLSQTKRQ------LSEREQQLVEKSGE 2040
Query: 449 AALTDSEDES--PEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAE 506
E +S + L L ER A +EA + Q + + +L E
Sbjct: 2041 LLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI----QRSQLEKNL---LE 2093
Query: 507 DSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYD 545
+S + E + + Q E A L+ EL Y+
Sbjct: 2094 QKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYE 2132
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/333 (20%), Positives = 146/333 (43%), Gaps = 20/333 (6%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS- 175
+ +++E +DL+Q K LE +V EL VQ+ ++ LM + + I +S
Sbjct: 1353 EKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE-IEKSL 1411
Query: 176 --HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
H +I +E + + + + R EL + + ++E ++ ++ V+ T +
Sbjct: 1412 KHHEDIVDEIECIEKTL---LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468
Query: 234 KLL---GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQ---KATLLGEELASAAAA 287
LL +E++ +++ L +QLR Q A +Q K + +E+ AA
Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA 1528
Query: 288 RDRTIAELHRSRLEVAEVNGRLA---ELGLHLKEEKCQWSKERAGLLQSVEAE----KDK 340
+D L + + ++ E +L E+ ++ Q KE LLQ+ AE K +
Sbjct: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
+ E+ L++ + ++ + + + + + K L + E+TE + +R ++
Sbjct: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSL 1648
Query: 401 KEQLQEEKQELLEYMRKLEARLEKVADEKWNED 433
E+L +K EL + + + +L + E E+
Sbjct: 1649 LEELSFQKGELNVQISERKTQLTLIKQEIEKEE 1681
Score = 53.5 bits (127), Expect = 5e-07
Identities = 59/323 (18%), Positives = 153/323 (47%), Gaps = 23/323 (7%)
Query: 109 VVPKATVLQ-NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELME 167
++ A +Q +++ +Q RND M L+ T L +++++ E+ ++ A+ +EL +
Sbjct: 404 IIDSAQAVQIKKMEPDEQLRNDHMNLRGH-----TPLDTQLEDKEKKISAAQTRLSELHD 458
Query: 168 QYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL-DRLR---- 222
+ + + TEE +Q + ++ ++ + + + K L+ ++L ++LR
Sbjct: 459 EIEKAEQQILRATEEF-----KQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
Query: 223 DTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELA 282
D + ++++++ G+ KE++ D + + L+ + + + +Q+ ++ ++
Sbjct: 514 DLELQMEKQKQEIAGKQKEIK-DLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQ 572
Query: 283 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 342
+ D ++ + + E+ ++ +L E + E K+ G++ ++ I
Sbjct: 573 QLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEAL---KKDLEGVISGLQEYLGTIK 629
Query: 343 KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES---KRELTELRSALRVLQK 399
+ + + +++E+ TE+ +E+D + ++ ++EL EL SAL+ +
Sbjct: 630 GQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHE 689
Query: 400 EKEQLQEEKQELLEYMRKLEARL 422
LQ+ + +L Y +LEARL
Sbjct: 690 VNASLQQTQGDLSAYEAELEARL 712
Score = 52.8 bits (125), Expect = 9e-07
Identities = 76/381 (19%), Positives = 159/381 (41%), Gaps = 71/381 (18%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+ + + QQE + L + KL L ++ ++ ++QE A+ + ++E + + +
Sbjct: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA--LTREQE 233
T+ +D+L +Q I E + + ++ TK+ +L L++ ++ L Q+
Sbjct: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQ-ELAASSQQKATLLGEELASAAAARDR-- 290
+++ Q +Q ++E E++LE K L+ Q +L + + L + L+ AA +R
Sbjct: 1947 EMMFQ--RLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
Query: 291 ------------------TIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL- 331
T +L ++ E +G L L + +S R L
Sbjct: 2005 TLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLT 2064
Query: 332 QSVEAEKDKI-LKLSAEILR--LEKAVQEERTQNQVFKTELA------------------ 370
+ +AEK LK + +I R LEK + E++ +N + E+A
Sbjct: 2065 ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMK 2124
Query: 371 -------------------REKDSSLVQLSESKRELT-----ELRSALRVLQKEKEQLQE 406
++ + +++S++ R L E+R++L+ L + +L
Sbjct: 2125 ELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPA 2184
Query: 407 EKQELLEYMRKLEARLEKVAD 427
+ + +LE LE LE + +
Sbjct: 2185 DLEAILERNENLEGELESLKE 2205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 70/298 (23%), Positives = 136/298 (45%), Gaps = 48/298 (16%)
Query: 137 LEGQVTELRSRVQ-ELERALATARQEHTELMEQYKGISRSHGEITE--ERDILSRQQGD- 192
L+ Q +E+ +R + E + A R+ E+ Q + ++ E + ER + +R D
Sbjct: 843 LQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902
Query: 193 --HVARILELEDDIQTISEKVLTKEVELDRLRDT-VKALTREQEKLLGQLKEVQADKEQS 249
H ARI ++E++I + E + + E E+ L D ++ E+E++L QL+E++ K+
Sbjct: 903 RQHEARIQQMENEIHYLQENLKSME-EIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961
Query: 250 EAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRL 309
+A+ + EQ+ G + +KA ++LA+ AEL ++ ++ ++G +
Sbjct: 962 DAKSQ---EQVFGLDK-ELKKLKKAVATSDKLAT---------AELTIAKDQLKSLHGTV 1008
Query: 310 AELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL 369
++ ++ERA LQ E K + + ++ R E + E QN L
Sbjct: 1009 MKI-----------NQERAEELQEAERFSRKAAQAARDLTRAEAEI--ELLQN------L 1049
Query: 370 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVAD 427
R+K E T S + ++K E ++ ++ E+ ARL+ V D
Sbjct: 1050 LRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEI--------ARLQNVLD 1099
Score = 45.4 bits (106), Expect = 1e-04
Identities = 79/342 (23%), Positives = 137/342 (40%), Gaps = 67/342 (19%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+ QL E Q N+ LK LEG ++ L+ + ++ A+ E +L ++ + + +
Sbjct: 595 LEEQLTEGQIAANEA--LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQR 652
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
E+ +ERD L I+ + D + + +++ E L + +L + Q L
Sbjct: 653 LTEVEQERDQLE---------IVAM--DAENMRKELAELESALQEQHEVNASLQQTQGDL 701
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 295
E++A +AE LKE+L +K T L +L
Sbjct: 702 SAYEAELEARLNLRDAEANQLKEEL-----------EKVTRL---------------TQL 735
Query: 296 HRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
+S L+ AEL E++ Q K G Q E ++ + +L A++ L+
Sbjct: 736 EQSALQ--------AEL-----EKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
Query: 356 QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR-------------VLQKEKE 402
+ Q + F+ L D LV+ E + ELR L+ VL K
Sbjct: 783 NLLKQQLKDFQNHLNHVVD-GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLA 841
Query: 403 QLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 444
LQ++ E+L K E +V + K E+ + E+ A G
Sbjct: 842 DLQKQFSEILA-RSKWERDEAQVRERKLQEEMALQQEKLATG 882
Score = 43.5 bits (101), Expect = 6e-04
Identities = 41/159 (25%), Positives = 76/159 (47%), Gaps = 19/159 (11%)
Query: 114 TVLQNQ-LDESQQERNDLMQLKLQLEGQVTELRSRVQE-------LERALAT----ARQE 161
++L+NQ L E ++ + LK L+ Q ++L + E +++ +AT A+
Sbjct: 2056 SLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDN 2115
Query: 162 HTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRL 221
H K +++ E TE + ++ Q+ D R +E+ D ++T+ +V D +
Sbjct: 2116 HERARRLMKELNQMQYEYTELKKQMANQK-DLERRQMEISDAMRTLKSEVK------DEI 2168
Query: 222 RDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQL 260
R ++K L + +L L+ + E E ELE LKE L
Sbjct: 2169 RTSLKNLNQFLPELPADLEAILERNENLEGELESLKENL 2207
Score = 38.5 bits (88), Expect = 0.018
Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 26/213 (12%)
Query: 238 QLKEVQADKEQSEAELE-----PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
Q+K+++ D++ + PL QL ++ +++Q + + L +E+ A R
Sbjct: 412 QIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT 471
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
E +LE A +++E G L K+ +G LQ V + + L L L++E
Sbjct: 472 EEF--KQLEEAIQLKKISEAGKDLLY------KQLSGRLQLVNKLRQEALDLE---LQME 520
Query: 353 KAVQE-ERTQNQVFKTELAREK-DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
K QE Q ++ ++A + DS + S K + + L ++ K+ +QL+ E
Sbjct: 521 KQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDE 580
Query: 411 LLEYMRKLEARLEKVADE-KWNEDATTEDEEAA 442
+L +R+ K +E K E+ TE + AA
Sbjct: 581 IL-------SRIAKETEEIKDLEEQLTEGQIAA 606
Score = 31.6 bits (70), Expect = 2.2
Identities = 18/60 (30%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Query: 366 KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 425
+ E++R +D + L KRE +R++ R +KE E+L +LL+ + LE +E++
Sbjct: 1322 ENEVSRLEDI-MQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 79.0 bits (193), Expect = 1e-14
Identities = 77/343 (22%), Positives = 154/343 (44%), Gaps = 35/343 (10%)
Query: 114 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
T L+ +L +++R +L + + +LEG T+L ++ EL+ +A + + + E+ +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
E ++++ ++ + ++I EL++D++ SE+ + E +Q+
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLE--SERASRNKAE-------------KQK 1134
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
+ LG+ + E + ELE + QEL + +Q+ +L + L A + I
Sbjct: 1135 RDLGE------ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 294 ELHRSRLEVAE-----------VNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 342
E+ + + E V L + L+ E+ + + E LLQ + K
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 343 KLSAEILRLEKAVQE-ERTQNQVFK--TELAREKDSSLVQLSESKRELTELRSALRVLQK 399
K+ A++ L+ E ER + ++ T+L E D+ LS+S + ++L L+
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 400 EKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 442
+ + QE QE L +L++V DEK + E+EE A
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Score = 77.8 bits (190), Expect = 3e-14
Identities = 105/441 (23%), Positives = 189/441 (42%), Gaps = 92/441 (20%)
Query: 86 QEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQV---T 142
Q R +E++ EE +++ V K +N+L E + ++ LM KLQL+ Q+ T
Sbjct: 839 QVSRQEEEMMAKEE-----ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 143 ELRSRVQELERALATARQE----------------------HTELMEQYKGISRSHGEIT 180
EL + +EL L +QE E + + I ++
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 181 EERDILSRQQGDHV---ARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQE 233
EE + Q + V A++ +LE++ + ++ L KE +L DR+ + LT E+E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 234 K-------------LLGQLKEVQADKEQSEAELEPLKEQLRG-----AQELAASSQQKAT 275
K ++ L+E +E+ ELE + +L G + ++A Q A
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 276 L------LGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK---- 325
L EEL +A A + A+ + + ++ E+ +++EL L+ E+ +K
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 326 -------------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE 372
E L S A+++ K E+ L+K ++EE ++ E+ R+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM-RQ 1192
Query: 373 KDSSLV-----QLSESKRELTELRSALRVLQKEKEQLQEEKQELLE-------YMRKLEA 420
K S V QL ++KR L A + L+ E+ +L E + LL+ +K+EA
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252
Query: 421 RLEKVADEKWNEDATTEDEEA 441
+L+++ K+NE E A
Sbjct: 1253 QLQEL-QVKFNEGERVRTELA 1272
Score = 76.6 bits (187), Expect = 6e-14
Identities = 69/310 (22%), Positives = 143/310 (46%), Gaps = 17/310 (5%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
D ++ E + L L + E + ELER R E +LM + +S E+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR-DTVKALTREQEKLLGQL 239
+ + L +Q + ++ ELED++Q + L EV L ++ + L E+ +
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584
Query: 240 KEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATL----LGEELASAAAARDRTIAEL 295
K++ + EAELE ++Q + +A ++++K + L + SA RD I +L
Sbjct: 1585 KQLVRQVREMEAELEDERKQ----RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 296 HRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
+ + ++ + L + +EE +KE L+S+EAE +++L E+ E+A
Sbjct: 1641 RKLQAQMKDCMRELDDTRAS-REEILAQAKENEKKLKSMEAE---MIQLQEELAAAERAK 1696
Query: 356 QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYM 415
++ + + E+A + L E +R L + + L++E E+ Q + + + +
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRR----LEARIAQLEEELEEEQGNTELINDRL 1752
Query: 416 RKLEARLEKV 425
+K +++++
Sbjct: 1753 KKANLQIDQI 1762
Score = 72.0 bits (175), Expect = 1e-12
Identities = 82/356 (23%), Positives = 162/356 (45%), Gaps = 53/356 (14%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
++ QL+E + E KL+LE L++ + ER L R E +E E+ K + R
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLE---VNLQAMKAQFERDLQ-GRDEQSE--EKKKQLVRQ 1590
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELD-------RLRDTVKAL 228
E+ E + +Q+ VA +LE D++ + + + D +L+ +K
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 229 TRE-------QEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
RE +E++L Q KE + + EAE+ L+E+L A+ +QQ+ L +E+
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 282 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 341
A+++ + E R + R+A+L L+EE+ + E D++
Sbjct: 1711 ANSSGKGALALEEKRR-------LEARIAQLEEELEEEQ-----------GNTELINDRL 1752
Query: 342 LKLSAEILRLEKAVQEERT---QNQVFKTELAREKDSSLVQLSES--------KRELTEL 390
K + +I ++ + ER+ +N+ + +L R+ V+L E K +T L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 391 RSALRVLQKEKEQLQEEKQELLEYMRKLEARLE----KVADEKWNEDATTEDEEAA 442
+ + L+++ + +E+Q + +R+ E +L+ +V DE+ N + + + A
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Score = 65.1 bits (157), Expect = 2e-10
Identities = 81/361 (22%), Positives = 160/361 (44%), Gaps = 56/361 (15%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELR-----------------SRVQELERA 154
K ++ QL E Q + N+ +++ +L +VT+L+ S++ + A
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 155 LATARQEHTELME----QYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEK 210
L + Q+ EL++ Q +S ++ +E++ Q + LE I T+ +
Sbjct: 1306 LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 211 VLTKEVELD--------------RLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPL 256
V + +++ +L+ ++ L++ E+ + +++ K + + EL+ L
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 257 KEQLRGAQELAASSQQKA----TLLGEE---LASAAAARDRTIAELHRSRLEVAEVNGRL 309
L ++ A + ++K LL EE A A RDR AE + + R
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL-ARA 1484
Query: 310 AELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR----LEKAVQEERTQNQVF 365
E + K E + +K+ ++ + + KD + K E+ + LE+ V+E +TQ +
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 366 KTELAREKDSSL---VQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARL 422
+ EL +D+ L V L K + R LQ EQ +E+K++L+ +R++EA L
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFE------RDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 423 E 423
E
Sbjct: 1599 E 1599
Score = 61.2 bits (147), Expect = 3e-09
Identities = 92/441 (20%), Positives = 179/441 (40%), Gaps = 100/441 (22%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
+T Q +L +++ ++++ L+ E + E +++QE+ + + A +E E +EQ K +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHE--AQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 173 SRS-----------HGEITEERDILSRQQGDHVARILELEDDIQTI-------------- 207
+ GE+ E +L + +GD + ++E +Q +
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 208 SEKVLTKEVELD-------------------------RLRDTVKALTREQEKLLG---QL 239
++KV +VELD +L+DT + L E + L +L
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 240 KEVQADKEQSEAELEPLKEQ----------------------------LRGAQELAASSQ 271
K+V+ +K +LE +E L A+E+ Q
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 272 QKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
+ L + AA D+ E ++RL+ E++ L +L H ++ C K++
Sbjct: 1392 KDLEGLSQRHEEKVAAYDK--LEKTKTRLQ-QELDDLLVDLD-HQRQSACNLEKKQKKFD 1447
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
Q + EK K + E R E +E+ T+ LAR + ++ Q +E +R + R
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETK----ALSLARALEEAMEQKAELERLNKQFR 1503
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV---ADEKWNEDATTEDEEAAVGLSCP 448
+ + L K+ + + EL + R LE ++E++ +E +E TED + + ++
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 449 AALTDSE------DESPEDMR 463
A E DE E+ +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKK 1584
Score = 52.8 bits (125), Expect = 9e-07
Identities = 65/292 (22%), Positives = 131/292 (44%), Gaps = 37/292 (12%)
Query: 119 QLDESQQERNDLM------QLKLQ-LEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
+LD+++ R +++ + KL+ +E ++ +L+ + ERA A+QE EL ++
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 172 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 231
S EE+ L ARI +LE++++ E+ E+ DRL+ + +
Sbjct: 1713 SSGKGALALEEKRRLE-------ARIAQLEEELE---EEQGNTELINDRLKKANLQIDQI 1762
Query: 232 QEKLLGQLKEVQAD---KEQSEAELEPLKEQLRGAQELAASSQQKA--TLLGEELASAAA 286
L + Q + ++Q E + + LK +L+ E S+ KA T L ++A
Sbjct: 1763 NTDLNLERSHAQKNENARQQLERQNKELKVKLQ-EMEGTVKSKYKASITALEAKIAQLEE 1821
Query: 287 ARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSA 346
D E + +V +L ++ L + +E+ ++ E KD+ K S
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDDER-----------RNAEQYKDQADKAST 1870
Query: 347 EILRLEKAVQEERTQNQ---VFKTELAREKDSSLVQLSESKRELTELRSALR 395
+ +L++ ++E + Q + +L RE + + RE++ L++ LR
Sbjct: 1871 RLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 29.6 bits (65), Expect = 8.4
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 4/75 (5%)
Query: 373 KDSSLVQLSE----SKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
K+ LV++ E ++ LTE+ + L EK QLQE+ Q E + E ++ +
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 429 KWNEDATTEDEEAAV 443
K + D EA V
Sbjct: 910 KQELEEICHDLEARV 924
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 79.0 bits (193), Expect = 1e-14
Identities = 79/343 (23%), Positives = 151/343 (44%), Gaps = 39/343 (11%)
Query: 122 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 173
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA------ 227
+ ++T+E+ L + + ED + T+++ E ++D L +++
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCM 1050
Query: 228 -LTREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGE 279
L R + KL G LK + + DK+Q +L+ + ++ Q Q A L +
Sbjct: 1051 DLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQK 1110
Query: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
++ A + E+ R A+ + ++L L+E E AG S + E +
Sbjct: 1111 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERLEEAGGATSAQIEMN 1168
Query: 340 KILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 399
K K AE ++ + ++E Q++ L ++ S+ +L E + LQ+
Sbjct: 1169 K--KREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQ----------IDSLQR 1216
Query: 400 EKEQLQEEKQELLEYMRKLEARLEKVADEKWNED---ATTEDE 439
K++L++EK EL + L + +E V+ K N + T ED+
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQ 1259
Score = 74.3 bits (181), Expect = 3e-13
Identities = 70/330 (21%), Positives = 142/330 (43%), Gaps = 36/330 (10%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
+Q+ LD + RND +++K ++EG + E+ ++ R A A + K
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
R ++ E+ ++ R+ A + EL ++ E EL + V+ L
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ L+ K+++ D Q + E+E + ++ R A+E A + A ++ EEL
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKK----E 1776
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 348
T A L R + + + + +L L L E + +++ K +I KL A +
Sbjct: 1777 QDTSAHLERMKKNMEQT---VKDLQLRLDEAE----------QLALKGGKKQIQKLEARV 1823
Query: 349 LRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRE-----------LTELRSALRVL 397
LE V+ E+ N V + R+ + + +L+ E + +L++ ++
Sbjct: 1824 RELESEVESEQKHN-VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Query: 398 QKEKEQLQEEKQELLEYMRKLEARLEKVAD 427
+++ E+ +E+ L RKL+ LE+ +
Sbjct: 1883 KRQAEEAEEQSNVNLAKFRKLQHELEEAKE 1912
Score = 72.4 bits (176), Expect = 1e-12
Identities = 82/355 (23%), Positives = 164/355 (46%), Gaps = 67/355 (18%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQE-------LERALATARQEHTELMEQY-- 169
QLDE + L + K Q+ EL+ +++E L AL +AR + L EQY
Sbjct: 1294 QLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEE 1353
Query: 170 ---------KGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDR 220
+G+S+++ E+ + R ++ + D + R ELE+ + +++++ E ++
Sbjct: 1354 EQEAKAELQRGMSKANSEVAQWR---TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 221 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAA------------ 268
+ +L + +++L +++++ D E+S A L ++ R ++ A
Sbjct: 1411 VNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE 1470
Query: 269 --SSQQKATLLGEELASAAAARDRTIAELH-------RSRLEVAEVNGRLAELGLH---L 316
+SQ+++ L EL A + ++ L + E++++ ++AE G H L
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 317 KEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAR---EK 373
++ K Q E++ L S+E + + +ILR++ + NQV K+E+ R EK
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL------NQV-KSEIDRKIAEK 1583
Query: 374 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEE---KQELLEYMRKLEARLEKV 425
D L QL R+ LRV++ + L E + + L +K+E L ++
Sbjct: 1584 DEELDQLK---------RNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEM 1629
Score = 69.3 bits (168), Expect = 1e-11
Identities = 84/405 (20%), Positives = 166/405 (40%), Gaps = 83/405 (20%)
Query: 112 KATVLQNQLDESQQERND---------------------LMQLKLQLEGQV--------- 141
K L+ ++ QE+ND L++ K+QLE ++
Sbjct: 873 KRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAED 932
Query: 142 -------------------TELRSRVQELERALATARQEH-------TELMEQYKGISRS 175
+EL+ + +LE LA +E L E+ G+ +
Sbjct: 933 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET 992
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA-------L 228
++T+E+ L + + ED + T+++ E ++D L +++ L
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052
Query: 229 TREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
R + KL G LK + + DK+Q +L+ + ++ Q Q A L +++
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI 1112
Query: 282 ASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKI 341
A + E+ R A+ + ++L L E+ E AG S + E +K
Sbjct: 1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSREL--EEISERLEEAGGATSAQIEMNK- 1169
Query: 342 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 401
K AE ++ + ++E Q++ L ++ S+ +L E ++ L+ + L+KEK
Sbjct: 1170 -KREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE---QIDSLQRVKQKLEKEK 1225
Query: 402 EQLQEEKQEL---LEYMRKLEARLEKVA---DEKWNEDATTEDEE 440
+L+ E +L +E + K +A EK+ +++ +E T E+E+
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ 1270
Score = 63.5 bits (153), Expect = 5e-10
Identities = 66/320 (20%), Positives = 143/320 (44%), Gaps = 23/320 (7%)
Query: 110 VPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRV-QELERALATARQEHTELMEQ 168
+ K T + L E+ Q+ D +Q++ +T+ ++++ Q+++ + QE M+
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
+ + G++ ++ ++ E+D Q ++EK+ KE E+ L+ ++
Sbjct: 1053 ERAKRKLEGDLKLAQE-----------STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDE 1101
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+L ++KE+QA E+ E E+E + A++ + ++ + E L A A
Sbjct: 1102 QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA- 1160
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 348
T A++ ++ AE +L EE + A L+ A D + +L +I
Sbjct: 1161 --TSAQIEMNKKREAEFQKMRRDL-----EESTLQHEATAAALRKKHA--DSVAELGEQI 1211
Query: 349 LRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK 408
L++ Q+ + K E+ + S++ +S++K ++ L E + +EE+
Sbjct: 1212 DSLQRVKQKLEKEKSELKMEI-NDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ 1270
Query: 409 QELLEYMRKLEARLEKVADE 428
Q L+ + +ARL + E
Sbjct: 1271 QRLINELSAQKARLHTESGE 1290
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/376 (20%), Positives = 157/376 (41%), Gaps = 61/376 (16%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L+ SQ+E L +++ E ++ L+R +QE ++L EQ +
Sbjct: 1468 QAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHI 1527
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
E+ + + L ++ + + E E ++ K+L ++EL++++ + E+++ L
Sbjct: 1528 HELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEL 1587
Query: 237 GQLK----------------EVQAD------KEQSEAELEPLKEQLRGAQELAASSQQKA 274
QLK E+++ K++ E +L ++ QL A AA + +
Sbjct: 1588 DQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNL 1647
Query: 275 ----------------TLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKE 318
+ G++ A A L ++ +E + E G + E
Sbjct: 1648 RNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE 1707
Query: 319 EKCQWSKERAGLLQS-----VEAEKDKILKLSAEILRLEKAVQEER----------TQNQ 363
++ + ER LL + + +K +S +E VQE R T
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767
Query: 364 VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL-----QEEKQELLEYMRKL 418
+ EL +E+D+S L K+ + + L++ E EQL +++ Q+L +R+L
Sbjct: 1768 MMAEELKKEQDTS-AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 419 EARLEKVADEKWNEDA 434
E+ +E +++K N +A
Sbjct: 1827 ESEVE--SEQKHNVEA 1840
Score = 40.0 bits (92), Expect = 0.006
Identities = 58/256 (22%), Positives = 103/256 (40%), Gaps = 45/256 (17%)
Query: 231 EQEKLLGQLKE----VQADKEQSEAELEPLKEQ----LRGAQELAASSQQKATLLG---- 278
E EK + +KE + + ++EA+ + L+E+ ++ +L Q +A L
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 279 --EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGL---LQS 333
++L + I E+ + E+N L L++E + K+ L L
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 334 VEAEK----DKILKLSAEILRLE----------KAVQEERTQN--------------QVF 365
VE EK +K+ L+ E+ L+ KA+QE Q
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 366 KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKV 425
KT+L ++ D L + K+ +L A R L+ + + QE + ++L +L+K
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKK 1087
Query: 426 ADEKWNEDATTEDEEA 441
E N EDE+A
Sbjct: 1088 EFEMSNLQGKIEDEQA 1103
Score = 38.1 bits (87), Expect = 0.024
Identities = 37/200 (18%), Positives = 84/200 (42%), Gaps = 27/200 (13%)
Query: 110 VPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY 169
+ A ++ +L + Q L ++K +E V +L+ R+ E E+ ++ + +E
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE-- 1820
Query: 170 KGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 229
AR+ ELE ++++ + + L + VK LT
Sbjct: 1821 -------------------------ARVRELESEVESEQKHNVEAVKGLRKHERRVKELT 1855
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ E+ + +Q ++ + +++ K Q A+E + + K L EL A D
Sbjct: 1856 YQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERAD 1915
Query: 290 RTIAELHRSRLEVAEVNGRL 309
+++++ R++ EV+ ++
Sbjct: 1916 IAESQVNKLRVKSREVHTKV 1935
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.2 bits (191), Expect = 2e-14
Identities = 80/325 (24%), Positives = 146/325 (44%), Gaps = 26/325 (8%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
+Q+ LD + RND ++LK ++EG + E+ ++ R A A + + K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
RS ++ E+ ++ R+ A I EL ++ E EL + V+ L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ L+ K+++ D Q + E+E + ++ R A+E A + A ++ EEL
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK----E 1778
Query: 289 DRTIAELHRSRLE----VAEVNGRLAEL-GLHLKEEKCQWSKERAGLLQSVEAEKDKILK 343
T A L R + V ++ RL E L LK K Q K A ++ +E E + K
Sbjct: 1779 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-RVRELEGEVESEQK 1837
Query: 344 LSAEILR-LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+AE ++ L K E R + ++TE R+ L L + +L++ ++ +++ E
Sbjct: 1838 RNAEAVKGLRK--HERRVKELTYQTEEDRKNILRLQDL------VDKLQAKVKSYKRQAE 1889
Query: 403 QLQEEKQELLEYMRKLEARLEKVAD 427
+ +E+ L RKL+ LE+ +
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEE 1914
Score = 77.8 bits (190), Expect = 3e-14
Identities = 76/343 (22%), Positives = 153/343 (44%), Gaps = 39/343 (11%)
Query: 122 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 173
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA------ 227
+ ++T+E+ L + + ED + T+++ + E ++D L +++
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 228 -LTREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGE 279
L R + KL G LK +++ +K+Q + +L+ + ++ Q Q L +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK 1112
Query: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
++ A + E+ R A+ + ++L L+E E AG S + E +
Sbjct: 1113 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERLEEAGGATSAQIEMN 1170
Query: 340 KILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 399
K K AE ++ + ++E Q++ L ++ S+ +L E + LQ+
Sbjct: 1171 K--KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ----------IDNLQR 1218
Query: 400 EKEQLQEEKQELLEYMRKLEARLEKVADEKWNED---ATTEDE 439
K++L++EK E+ + L + +E V+ K N + T ED+
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Score = 64.3 bits (155), Expect = 3e-10
Identities = 73/320 (22%), Positives = 140/320 (43%), Gaps = 45/320 (14%)
Query: 117 QNQLDESQQER---NDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
Q LD+ Q E N L + K++LE QV +L +++ ++ + +L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL-------- 1061
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
E D+ Q+ I+++E++ Q + EK+ KE E+ L+ + E E
Sbjct: 1062 --------EGDLKLAQES-----IMDIENEKQQLDEKLKKKEFEISNLQSKI-----EDE 1103
Query: 234 KLLG-----QLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ LG ++KE+QA E+ E E+E + A++ + ++ + E L A A
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA- 1162
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 348
T A++ ++ AE +L EE + A L+ A D + +L +I
Sbjct: 1163 --TSAQIEMNKKREAEFQKMRRDL-----EEATLQHEATAATLRKKHA--DSVAELGEQI 1213
Query: 349 LRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK 408
L++ Q+ + K E+ + S++ +S++K L ++ L E + +EE+
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEI-DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272
Query: 409 QELLEYMRKLEARLEKVADE 428
Q L+ + RL+ + E
Sbjct: 1273 QRLINDLTAQRGRLQTESGE 1292
Score = 60.1 bits (144), Expect = 6e-09
Identities = 79/434 (18%), Positives = 177/434 (40%), Gaps = 97/434 (22%)
Query: 97 LEEADGGSDILLVVPKATVLQNQLDESQQERND--------------------------- 129
L+ A+ ++ + + ++++L +S+ +R +
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 130 --------LMQLKLQLEGQV----------------------------TELRSRVQELER 153
L++ K+QLE ++ +EL+ + +LE
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 154 ALATARQEH-------TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 206
LA +E L E+ G+ + ++T+E+ L + + ED + T
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 207 ISEKVLTKEVELDRLRDTVKA-------LTREQEKLLGQLK-------EVQADKEQSEAE 252
+++ + E ++D L +++ L R + KL G LK +++ +K+Q + +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 253 LEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 312
L+ + ++ Q Q L +++ A + E+ R A+ + ++L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 313 GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE 372
L E+ E AG S + E +K K AE ++ + ++E Q++ L ++
Sbjct: 1146 SREL--EEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 373 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA--- 426
S+ +L E ++ L+ + L+KEK +++ E +L +E + K + LEK+
Sbjct: 1202 HADSVAELGE---QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 427 DEKWNEDATTEDEE 440
+++ +E + E+E+
Sbjct: 1259 EDQLSELKSKEEEQ 1272
Score = 58.9 bits (141), Expect = 1e-08
Identities = 84/371 (22%), Positives = 148/371 (39%), Gaps = 76/371 (20%)
Query: 118 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL----------ME 167
+QL+ ++E +L Q L Q+ E R+ ELE+ QE EL +E
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 168 QYKG---------------ISRSHGEITEERDILSRQQGDHVARILE-----LEDDIQTI 207
+G + R E EE D L R +H+ RI+E L+ +I++
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR---NHI-RIVESMQSTLDAEIRSR 1614
Query: 208 SEKVLTK----------EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLK 257
++ + K E++L+ R G LK+ Q + + E LK
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674
Query: 258 EQLRGAQELAASSQQKATLLGEELASAAAA-----RDRTIAELHRSRLEVAE-------V 305
EQL A +++A LL E+ A R R IAE + L+ +E
Sbjct: 1675 EQL-------AMVERRANLLQAEIEELRATLEQTERSRKIAE--QELLDASERVQLLHTQ 1725
Query: 306 NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEE------- 358
N L L+ + Q E +LQ ++K K + + + +++E
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785
Query: 359 ----RTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 414
+ Q K R ++ + L K+++ +L + +R L+ E E Q+ E ++
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG 1845
Query: 415 MRKLEARLEKV 425
+RK E R++++
Sbjct: 1846 LRKHERRVKEL 1856
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 69/345 (20%)
Query: 116 LQNQLDESQQERNDLMQLKLQ-------LEGQVTELRSRVQELERALATARQEHTELMEQ 168
L+ QL+E + +N L L Q E + EL+RAL+ A E + +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 169 YKGISRSHGEITEE--RDILSRQQG--DHV----ARILELEDDIQTISEKVLTKEVELDR 220
Y+ + E EE + + R Q +HV A+ LE Q + +V ++++R
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 221 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
AL ++Q L E + E++ AELE +SQ++A LG E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELE--------------ASQKEARSLGTE 1486
Query: 281 LASAAAARDRTIAELH-------RSRLEVAEVNGRLAELGLHLKE----------EKCQW 323
L A + ++ +L + E++++ ++AE G + E EKC+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCEL 1546
Query: 324 SKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 383
S+E E+ KIL++ E+ +++ V + EKD + QL
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK-----------IAEKDEEIDQLK-- 1593
Query: 384 KRELTELRSALRVLQKEKEQLQEE---KQELLEYMRKLEARLEKV 425
R+ +R+++ + L E + + + +K+E L ++
Sbjct: 1594 -------RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/353 (19%), Positives = 160/353 (45%), Gaps = 30/353 (8%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY-KGISRSHG 177
+L+ SQ+E L +++ E +++ L+R +QE ++L EQ +G R H
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH- 1530
Query: 178 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG 237
E+ + + + +++ + A + E E ++ K+L ++EL++++ V E+++ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 238 QLKE-----VQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
QLK V++ + +AE+ + +R +++ + L +R
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNH--------ANRMA 1642
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
AE R+ G L + +HL + + + L + + + + L AEI L
Sbjct: 1643 AEALRN---YRNTQGILKDTQIHLDDA----LRSQEDLKEQLAMVERRANLLQAEIEELR 1695
Query: 353 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
+++ ++ + EL S VQL ++ T L + + L+ + Q+Q E +++L
Sbjct: 1696 ATLEQTERSRKIAEQELL--DASERVQLLHTQN--TSLINTKKKLETDISQMQGEMEDIL 1751
Query: 413 EYMRKLEARLEK-VADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRL 464
+ R E + +K + D + ++++ + L + + +++ +D++L
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE---RMKKNMEQTVKDLQL 1801
Score = 40.8 bits (94), Expect = 0.004
Identities = 38/200 (19%), Positives = 86/200 (43%), Gaps = 27/200 (13%)
Query: 110 VPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY 169
+ A ++ +L + Q L ++K +E V +L+ R+ E E+ ++ + +E
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE-- 1822
Query: 170 KGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 229
AR+ ELE ++++ ++ L + VK LT
Sbjct: 1823 -------------------------ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ E+ + +Q ++ +A+++ K Q A+E + ++ K L EL A D
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Query: 290 RTIAELHRSRLEVAEVNGRL 309
+++++ R++ EV+ ++
Sbjct: 1918 IAESQVNKLRVKSREVHTKV 1937
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 78.2 bits (191), Expect = 2e-14
Identities = 80/325 (24%), Positives = 146/325 (44%), Gaps = 26/325 (8%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
+Q+ LD + RND ++LK ++EG + E+ ++ R A A + + K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH 1662
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
RS ++ E+ ++ R+ A I EL ++ E EL + V+ L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ L+ K+++ D Q + E+E + ++ R A+E A + A ++ EEL
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK----E 1778
Query: 289 DRTIAELHRSRLE----VAEVNGRLAEL-GLHLKEEKCQWSKERAGLLQSVEAEKDKILK 343
T A L R + V ++ RL E L LK K Q K A ++ +E E + K
Sbjct: 1779 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA-RVRELEGEVESEQK 1837
Query: 344 LSAEILR-LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+AE ++ L K E R + ++TE R+ L L + +L++ ++ +++ E
Sbjct: 1838 RNAEAVKGLRK--HERRVKELTYQTEEDRKNILRLQDL------VDKLQAKVKSYKRQAE 1889
Query: 403 QLQEEKQELLEYMRKLEARLEKVAD 427
+ +E+ L RKL+ LE+ +
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEE 1914
Score = 77.8 bits (190), Expect = 3e-14
Identities = 76/343 (22%), Positives = 153/343 (44%), Gaps = 39/343 (11%)
Query: 122 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 173
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 933 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 992
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA------ 227
+ ++T+E+ L + + ED + T+++ + E ++D L +++
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 228 -LTREQEKLLGQLK-------EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGE 279
L R + KL G LK +++ +K+Q + +L+ + ++ Q Q L +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK 1112
Query: 280 ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 339
++ A + E+ R A+ + ++L L+E E AG S + E +
Sbjct: 1113 KIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE--ISERLEEAGGATSAQIEMN 1170
Query: 340 KILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQK 399
K K AE ++ + ++E Q++ L ++ S+ +L E + LQ+
Sbjct: 1171 K--KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ----------IDNLQR 1218
Query: 400 EKEQLQEEKQELLEYMRKLEARLEKVADEKWNED---ATTEDE 439
K++L++EK E+ + L + +E V+ K N + T ED+
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261
Score = 64.3 bits (155), Expect = 3e-10
Identities = 73/320 (22%), Positives = 140/320 (43%), Gaps = 45/320 (14%)
Query: 117 QNQLDESQQER---NDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
Q LD+ Q E N L + K++LE QV +L +++ ++ + +L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL-------- 1061
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
E D+ Q+ I+++E++ Q + EK+ KE E+ L+ + E E
Sbjct: 1062 --------EGDLKLAQES-----IMDIENEKQQLDEKLKKKEFEISNLQSKI-----EDE 1103
Query: 234 KLLG-----QLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ LG ++KE+QA E+ E E+E + A++ + ++ + E L A A
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA- 1162
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 348
T A++ ++ AE +L EE + A L+ A D + +L +I
Sbjct: 1163 --TSAQIEMNKKREAEFQKMRRDL-----EEATLQHEATAATLRKKHA--DSVAELGEQI 1213
Query: 349 LRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK 408
L++ Q+ + K E+ + S++ +S++K L ++ L E + +EE+
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEI-DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272
Query: 409 QELLEYMRKLEARLEKVADE 428
Q L+ + RL+ + E
Sbjct: 1273 QRLINDLTAQRGRLQTESGE 1292
Score = 60.1 bits (144), Expect = 6e-09
Identities = 79/434 (18%), Positives = 177/434 (40%), Gaps = 97/434 (22%)
Query: 97 LEEADGGSDILLVVPKATVLQNQLDESQQERND--------------------------- 129
L+ A+ ++ + + ++++L +S+ +R +
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 130 --------LMQLKLQLEGQV----------------------------TELRSRVQELER 153
L++ K+QLE ++ +EL+ + +LE
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 154 ALATARQEH-------TELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 206
LA +E L E+ G+ + ++T+E+ L + + ED + T
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 207 ISEKVLTKEVELDRLRDTVKA-------LTREQEKLLGQLK-------EVQADKEQSEAE 252
+++ + E ++D L +++ L R + KL G LK +++ +K+Q + +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 253 LEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 312
L+ + ++ Q Q L +++ A + E+ R A+ + ++L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 313 GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE 372
L E+ E AG S + E +K K AE ++ + ++E Q++ L ++
Sbjct: 1146 SREL--EEISERLEEAGGATSAQIEMNK--KREAEFQKMRRDLEEATLQHEATAATLRKK 1201
Query: 373 KDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVA--- 426
S+ +L E ++ L+ + L+KEK +++ E +L +E + K + LEK+
Sbjct: 1202 HADSVAELGE---QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTL 1258
Query: 427 DEKWNEDATTEDEE 440
+++ +E + E+E+
Sbjct: 1259 EDQLSELKSKEEEQ 1272
Score = 58.9 bits (141), Expect = 1e-08
Identities = 84/371 (22%), Positives = 148/371 (39%), Gaps = 76/371 (20%)
Query: 118 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL----------ME 167
+QL+ ++E +L Q L Q+ E R+ ELE+ QE EL +E
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLE 1558
Query: 168 QYKG---------------ISRSHGEITEERDILSRQQGDHVARILE-----LEDDIQTI 207
+G + R E EE D L R +H+ RI+E L+ +I++
Sbjct: 1559 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR---NHI-RIVESMQSTLDAEIRSR 1614
Query: 208 SEKVLTK----------EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLK 257
++ + K E++L+ R G LK+ Q + + E LK
Sbjct: 1615 NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLK 1674
Query: 258 EQLRGAQELAASSQQKATLLGEELASAAAA-----RDRTIAELHRSRLEVAE-------V 305
EQL A +++A LL E+ A R R IAE + L+ +E
Sbjct: 1675 EQL-------AMVERRANLLQAEIEELRATLEQTERSRKIAE--QELLDASERVQLLHTQ 1725
Query: 306 NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEE------- 358
N L L+ + Q E +LQ ++K K + + + +++E
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1785
Query: 359 ----RTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 414
+ Q K R ++ + L K+++ +L + +R L+ E E Q+ E ++
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG 1845
Query: 415 MRKLEARLEKV 425
+RK E R++++
Sbjct: 1846 LRKHERRVKEL 1856
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 69/345 (20%)
Query: 116 LQNQLDESQQERNDLMQLKLQ-------LEGQVTELRSRVQELERALATARQEHTELMEQ 168
L+ QL+E + +N L L Q E + EL+RAL+ A E + +
Sbjct: 1321 LKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK 1380
Query: 169 YKGISRSHGEITEE--RDILSRQQG--DHV----ARILELEDDIQTISEKVLTKEVELDR 220
Y+ + E EE + + R Q +HV A+ LE Q + +V ++++R
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 221 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
AL ++Q L E + E++ AELE +SQ++A LG E
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELE--------------ASQKEARSLGTE 1486
Query: 281 LASAAAARDRTIAELH-------RSRLEVAEVNGRLAELGLHLKE----------EKCQW 323
L A + ++ +L + E++++ ++AE G + E EKC+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCEL 1546
Query: 324 SKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 383
S+E E+ KIL++ E+ +++ V + EKD + QL
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK-----------IAEKDEEIDQLK-- 1593
Query: 384 KRELTELRSALRVLQKEKEQLQEE---KQELLEYMRKLEARLEKV 425
R+ +R+++ + L E + + + +K+E L ++
Sbjct: 1594 -------RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/353 (19%), Positives = 160/353 (45%), Gaps = 30/353 (8%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY-KGISRSHG 177
+L+ SQ+E L +++ E +++ L+R +QE ++L EQ +G R H
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH- 1530
Query: 178 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG 237
E+ + + + +++ + A + E E ++ K+L ++EL++++ V E+++ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 238 QLKE-----VQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
QLK V++ + +AE+ + +R +++ + L +R
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNH--------ANRMA 1642
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
AE R+ G L + +HL + + + L + + + + L AEI L
Sbjct: 1643 AEALRN---YRNTQGILKDTQIHLDDA----LRSQEDLKEQLAMVERRANLLQAEIEELR 1695
Query: 353 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
+++ ++ + EL S VQL ++ T L + + L+ + Q+Q E +++L
Sbjct: 1696 ATLEQTERSRKIAEQELL--DASERVQLLHTQN--TSLINTKKKLETDISQMQGEMEDIL 1751
Query: 413 EYMRKLEARLEK-VADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRL 464
+ R E + +K + D + ++++ + L + + +++ +D++L
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE---RMKKNMEQTVKDLQL 1801
Score = 40.8 bits (94), Expect = 0.004
Identities = 38/200 (19%), Positives = 86/200 (43%), Gaps = 27/200 (13%)
Query: 110 VPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY 169
+ A ++ +L + Q L ++K +E V +L+ R+ E E+ ++ + +E
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE-- 1822
Query: 170 KGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 229
AR+ ELE ++++ ++ L + VK LT
Sbjct: 1823 -------------------------ARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
+ E+ + +Q ++ +A+++ K Q A+E + ++ K L EL A D
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERAD 1917
Query: 290 RTIAELHRSRLEVAEVNGRL 309
+++++ R++ EV+ ++
Sbjct: 1918 IAESQVNKLRVKSREVHTKV 1937
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 78.2 bits (191), Expect = 2e-14
Identities = 85/358 (23%), Positives = 161/358 (44%), Gaps = 50/358 (13%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
LQ + D SQ E+N+L++++LQL+ ++ +L+ + ++ Q EL+ + + +
Sbjct: 374 LQKKYDTSQDEQNELLKMQLQLQTELRQLK-----VMKSTLVENQSEKELLCRLQKLHLQ 428
Query: 176 HGEITEERD-ILSRQQG------DHVARILELEDDIQTI---SEKVLTKEVELDRLRDTV 225
H +T E++ +L RQQ H A + L D + + +EK +L ++
Sbjct: 429 HQNVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLY 488
Query: 226 KALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGE--ELAS 283
+A E E+ +++ D + EL+ LK ++ + + TLL EL
Sbjct: 489 QASKDELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRLTELQE 548
Query: 284 AAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEE--KCQWSKERAGLL---------- 331
A + + +L + E+ E R+ E L+EE + ++GLL
Sbjct: 549 KYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKL 608
Query: 332 ----------QSVEAEKDKILKLSAEILRLEKAVQEE--RTQNQVFKTELAREKDSSLVQ 379
Q ++ E+ K+++ +L+ + + EE R + F+ L DS L +
Sbjct: 609 EDLCELQLLYQGMQEEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAK 668
Query: 380 LSESKRE-----LTELRSALRVL----QKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
S+ R L E AL+V+ Q ++E LQ+E+ LLE ++L+A L+ +E
Sbjct: 669 SSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEE 726
Score = 56.6 bits (135), Expect = 6e-08
Identities = 71/339 (20%), Positives = 143/339 (42%), Gaps = 35/339 (10%)
Query: 94 LVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER 153
+ + E D L P+ +L+ QL +++++ + + + + EL ++EL+
Sbjct: 277 MTSAESQTSEMDFLEPDPEMQLLRQQLRDAEEQMHGM-------KNKCQELCCELEELQH 329
Query: 154 ALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLT 213
+ +E L + K + ++L Q V + EL+ + T+ +K T
Sbjct: 330 HRQVSEEEQRRLQRELK---------CAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDT 380
Query: 214 KEVELDRLRDTVKALTREQEKLLGQLKEVQAD--KEQSEAELEPLKEQLRGAQELAASSQ 271
+ E + L L E L QLK +++ + QSE EL ++L + +
Sbjct: 381 SQDEQNELLKMQLQLQTE----LRQLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEK 436
Query: 272 QKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL 331
+K ++L + + L + E N + E L+E K + +
Sbjct: 437 EKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQASK---- 492
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQV--FKTELAREKDSSLVQLSESKRELTE 389
+E +K +L ++L + ++E + + + K + A + D+ L +L TE
Sbjct: 493 DELERQKHMYDQLEQDLLLCQLELKELKASHPIPEDKGKCANKCDTLLSRL-------TE 545
Query: 390 LRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
L+ + QKE QLQ E+ ELLE R+++ ++ +E
Sbjct: 546 LQEKYKASQKEMGQLQMEQCELLEDQRRMQEEQGQLQEE 584
Score = 53.9 bits (128), Expect = 4e-07
Identities = 60/235 (25%), Positives = 97/235 (41%), Gaps = 29/235 (12%)
Query: 215 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPL--KEQLRGAQELAASSQQ 272
E EL+ LR V L E E + +E+ E EL+ L E+L AQ+ ++Q
Sbjct: 55 ETELEELRAQVLQLVAELE----ETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQ 110
Query: 273 KATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQ 332
L GE + R+ H E+ E+ E LHL + + Q S +A
Sbjct: 111 IQQLQGE----LRSLREEISLLEHEKESELKEI-----EQELHLAQAEIQ-SLRQAAEDS 160
Query: 333 SVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES--------- 383
+ E E D I L ++ R++ +++ ++ E+A + ++ SE
Sbjct: 161 ATEHESD-IASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDY 219
Query: 384 ---KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDAT 435
+ EL ELR L +E LQE L + LE+ + A E+W + T
Sbjct: 220 SGLQEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQT 274
Score = 53.1 bits (126), Expect = 7e-07
Identities = 83/385 (21%), Positives = 163/385 (42%), Gaps = 46/385 (11%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+ + +E ++E + + ++Q G V L R L+ E EL Q + +
Sbjct: 16 EEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKH---RGLSLTETELEELRAQ---VLQLV 69
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISE--KVLTKEV-----ELDRLRDTVKALT 229
E+ E R++ + + D + LED+ ++ +V TK++ EL LR+ + L
Sbjct: 70 AELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLE 129
Query: 230 REQEKLLGQLKEVQADKEQSEAELEPLKEQLRGA----QELAASSQQKATLLGEELASAA 285
E+E +LKE++ + ++AE++ L++ + + AS Q+ + EL
Sbjct: 130 HEKE---SELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELEDME 186
Query: 286 AARDRTIAELHRSRLEV----AEVNGRLAELGLHLKEEKCQWSKERAGLL-QSVEAEKDK 340
R E+ R E+ +E +G L +E+ Q +ER L + A ++
Sbjct: 187 RIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRERYHFLNEEYRALQES 246
Query: 341 ILKLSAEILRLEKAVQEERT----QNQVFKTELAREKDSSL-------------VQLSES 383
L+ ++ LE + T Q+Q A + S + QL ++
Sbjct: 247 NSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQLLRQQLRDA 306
Query: 384 KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK---WNEDATTEDEE 440
+ ++ +++ + L E E+LQ +Q E R+L+ L+ +E + T++EE
Sbjct: 307 EEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEE 366
Query: 441 AAVGLSCPAALTD-SEDESPEDMRL 464
L D S+DE E +++
Sbjct: 367 LKSRLCTLQKKYDTSQDEQNELLKM 391
Score = 47.4 bits (111), Expect = 4e-05
Identities = 55/234 (23%), Positives = 107/234 (45%), Gaps = 11/234 (4%)
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLR---GAQELAASSQQKATLLGEELASAAAA 287
E E LL L E + ++E+ E E+E +EQ++ L+ + + +L EL A
Sbjct: 5 EGEVLLPALYEEEEEEEEEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTETELEELRAQ 64
Query: 288 RDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE 347
+ +AEL +R + EL L++E+ +++ + ++ + ++ L E
Sbjct: 65 VLQLVAELEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREE 124
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
I LE + E + + + LA+ + SL Q +E TE S + LQ++ ++Q E
Sbjct: 125 ISLLEHEKESELKEIEQ-ELHLAQAEIQSLRQAAED--SATEHESDIASLQEDLCRMQNE 181
Query: 408 KQELLEYMRKLEARLE-KVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPE 460
LE M ++ E ++A + + + + ++GLS + L + E E
Sbjct: 182 ----LEDMERIRGDYEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE 231
Score = 42.0 bits (97), Expect = 0.002
Identities = 81/375 (21%), Positives = 139/375 (37%), Gaps = 81/375 (21%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DE E D+ + E V ++ ++Q ++ +++EH++L EQ + + ++
Sbjct: 837 DEEPAEPEDMERF----EEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLK 892
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
EE D R+ + + LE Q ++ + +L L+ +A EQ +LL
Sbjct: 893 EELDACEREFKECM-ECLEKPMAPQNDKNEIKELQTKLRELQLQYQASMDEQGRLL---- 947
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
+EQ E +L+ +E+LR +E S
Sbjct: 948 ---VVQEQLEGQLQCCQEELRQLREKRPS------------------------------- 973
Query: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 360
V E G+ A ++ + K S +E D + S E++ KA Q
Sbjct: 974 VVKEARGKNANKNMNKNANGVKMKKVTKPC--SDTSESDLETRKSLEVVLYYKASQ---- 1027
Query: 361 QNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE------KQELLEY 414
K L + E K E+ E + +V ++ KEQ +E E +
Sbjct: 1028 -----------RKLDGLAKEEEKKEEMEEEKK--QVKEEAKEQCGDELVAEPADPEEAKS 1074
Query: 415 MRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGD 474
E E +E+ ED+ E+++A DS ESPE+ P L E
Sbjct: 1075 TEDQEENEEDKEEEEKEEDSEEEEDDA-----------DSSLESPEENN--PLRLSESKK 1121
Query: 475 PGSSPAGPREASPLV 489
+P P + PLV
Sbjct: 1122 SSPTPNPPIFSLPLV 1136
Score = 40.4 bits (93), Expect = 0.005
Identities = 71/300 (23%), Positives = 122/300 (40%), Gaps = 49/300 (16%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
K+L +L+ VQA + S+ E L+EQ+ +++ E ++ +A
Sbjct: 855 KVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMA 914
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 353
+ E+ E+ +L EL L Q S + G L V+ + + L+ E LR +
Sbjct: 915 P-QNDKNEIKELQTKLRELQLQY-----QASMDEQGRLLVVQEQLEGQLQCCQEELRQLR 968
Query: 354 -----AVQEERTQN---QVFKTELAREKDSSLVQLSESKRELTELRSALRVL-------- 397
V+E R +N + K + S++ E R +L V+
Sbjct: 969 EKRPSVVKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQR 1028
Query: 398 --------QKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDA-TTEDEEAAVGLSCP 448
+++KE+++EEK+++ E ++ + E VA+ E+A +TED+E
Sbjct: 1029 KLDGLAKEEEKKEEMEEEKKQVKEEAKE-QCGDELVAEPADPEEAKSTEDQEENE----- 1082
Query: 449 AALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVI----SQPAPISPHLSGP 504
D E+E E+ E D SS P E +PL + S P P P S P
Sbjct: 1083 ---EDKEEEEKEEDSEE-----EEDDADSSLESPEENNPLRLSESKKSSPTPNPPIFSLP 1134
Score = 37.4 bits (85), Expect = 0.040
Identities = 36/156 (23%), Positives = 73/156 (46%), Gaps = 12/156 (7%)
Query: 106 ILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL 165
+ L +PK+ +L E + DL +L+L +G E + +Q + L +E E+
Sbjct: 588 LTLPLPKSGLLLKS-QELLTKLEDLCELQLLYQGMQEEQKKLIQNQDCVL----KEQLEI 642
Query: 166 MEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT--ISEKVLTKEVELDRLRD 223
E+ + SH + ++L +A+ + + Q+ + E++ +V D +
Sbjct: 643 HEELRRFKESHFQ-----EVLENPDDSKLAKSSKCNRNKQSKLLMEQMQALQVMYDAGQA 697
Query: 224 TVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQ 259
+ L +EQ +LL + K +QAD + E++ L+ Q
Sbjct: 698 KQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQ 733
Score = 36.2 bits (82), Expect = 0.090
Identities = 56/340 (16%), Positives = 137/340 (40%), Gaps = 30/340 (8%)
Query: 115 VLQNQ---LDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
++QNQ L E + +L + K +V E + + + ++ LMEQ +
Sbjct: 628 LIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNRNKQSKLLMEQMQA 687
Query: 172 ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE 231
+ + ++++L ++QG + L+ D+Q E++ +V+ ++ ++++ +
Sbjct: 688 LQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMSLESYGKS 747
Query: 232 QEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRT 291
++ + + + + + E + Q +S + + SA+ A ++
Sbjct: 748 YGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQ----TSSKSFLKSYDSSTSASEAYGKS 803
Query: 292 IAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRL 351
S + + G + K + E + +E ++ ++K+ ++ +
Sbjct: 804 YCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVVKVLIKLQAV 863
Query: 352 E---KAVQEERTQ-NQVFKTELAREKD-------------------SSLVQLSESKRELT 388
+ + QEE +Q + + LA++KD + K E+
Sbjct: 864 QAMYQISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAPQNDKNEIK 923
Query: 389 ELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
EL++ LR LQ + + +E+ LL +LE +L+ +E
Sbjct: 924 ELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEE 963
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 77.0 bits (188), Expect = 5e-14
Identities = 100/382 (26%), Positives = 170/382 (44%), Gaps = 41/382 (10%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQV---TELRSRVQEL-ERALATARQEHTELME 167
K LQ +LDE ++R L ++ LE Q+ TE SR+QEL ER A+Q + EL
Sbjct: 367 KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN 426
Query: 168 QYK----GISRSHG---EITEERDILSRQQGDHVARILELEDDIQT--ISEKVLTKEVEL 218
+ G HG ++ E ++ L QG A+ + L+D ++T + E+VL +
Sbjct: 427 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK--- 483
Query: 219 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLG 278
R+ + ++ RE L G LKE A ++Q E+E +++Q + E S Q AT
Sbjct: 484 QRVEEQLRLRERELTALKGALKEEVASRDQ---EVEHVRQQYQRDTEQLRRSMQDATQDH 540
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEK 338
L + + L R E +E G + KE+ + +K+ L+ + E
Sbjct: 541 AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED-LRATKQELLQLRMEKEEM 599
Query: 339 DKILKLSAEILRLE----KAVQEERTQNQVFKTELAR----------EKDSSLVQLSESK 384
++ L E+L+ E +A + Q +V K EL R E+ S V
Sbjct: 600 EEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRD 659
Query: 385 RELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 444
REL + + LRV +L+E+ +L + +++L E+ + K E E +G
Sbjct: 660 RELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAK----MVAEAEATVLG 715
Query: 445 ---LSCPAALTDSEDESPEDMR 463
+ L ++++E+ E R
Sbjct: 716 QRRAAVETTLRETQEENDEFRR 737
Score = 67.4 bits (163), Expect = 4e-11
Identities = 87/333 (26%), Positives = 153/333 (45%), Gaps = 59/333 (17%)
Query: 114 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
++ Q ++ + + +L+QL+++ E EL +++ L+R L AR
Sbjct: 573 SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARA------------- 619
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
S G+ T + ++L ++ +L +++++ + + ++EV R RD RE E
Sbjct: 620 -SAGD-TRQVEVLKKE-------LLRTQEELKELQAERQSQEVA-GRHRD------RELE 663
Query: 234 KLLGQLKEVQADK----EQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 289
K L L+ V+AD+ E+ +L+ +QLR E A+ ++ A L AA +
Sbjct: 664 KQLAVLR-VEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVE 722
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL---QSVEAE-KDKILKLS 345
T+ E E R LGL Q KE GL+ ++VEA +DK+ +L
Sbjct: 723 TTLRETQEENDEF-----RRRILGLE------QQLKETRGLVDGGEAVEARLRDKLQRLE 771
Query: 346 AEILRLEKAV---QEERTQNQVFKTELA---REKDSSLVQLSESK----RELTELRSALR 395
AE +LE+A+ QEE K L E L +L + + R L E
Sbjct: 772 AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE 831
Query: 396 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
VL++ K +L+E+K+ L + +L LEK+ ++
Sbjct: 832 VLRRGKAELEEQKRLLDRTVDRLNKELEKIGED 864
Score = 66.6 bits (161), Expect = 6e-11
Identities = 74/295 (25%), Positives = 123/295 (41%), Gaps = 21/295 (7%)
Query: 129 DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSR 188
+L + LQL+ + +LR +E +A A E T L ++ + + E EE D R
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
Query: 189 QQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQ 248
RIL LE ++ V E RLRD ++ L E+++L L Q ++
Sbjct: 738 -------RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Query: 249 SEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR 308
A L+ +L AQ A Q+ L L R+ L R + E+ E
Sbjct: 791 LAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQRE----VLRRGKAELEEQKRL 846
Query: 309 LAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTE 368
L L +E E+ G E K + +L A++ ++ + E Q +
Sbjct: 847 LDRTVDRLNKE-----LEKIG-----EDSKQALQQLQAQLEDYKEKARREVADAQRQAKD 896
Query: 369 LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 423
A E + + LS + E+ LR AL+ Q E++ + +K+ L + ++ LE E
Sbjct: 897 WASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAE 951
Score = 63.2 bits (152), Expect = 7e-10
Identities = 71/329 (21%), Positives = 137/329 (41%), Gaps = 17/329 (5%)
Query: 116 LQNQLDE-SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
L +L++ + + L QL+ QLE + R V + +R A+ +E + G+SR
Sbjct: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQ---AKDWASEAEKTSGGLSR 910
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
EI R L Q E D + +++L + L L + R Q+
Sbjct: 911 LQDEIQRLRQALQASQA---------ERDTARLDKELLAQR--LQGLEQEAENKKRSQDD 959
Query: 235 LLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAE 294
QLK ++ + E EL+ K + + + + L EL +AR +
Sbjct: 960 RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECD 1019
Query: 295 LHRSRLEVAEVNGRLAEL-GLHLKEEKCQWSKERAGLLQS-VEAEKDKILKLSAEILRLE 352
+ ++ RLA G + + LLQ ++AE+ + L + +LE
Sbjct: 1020 KISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLE 1079
Query: 353 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
+ V+E Q + + + +KD +++ KR++ E + L +++ Q E +E
Sbjct: 1080 RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQH 1139
Query: 413 EYMRKLEARLEKVADEKWNEDATTEDEEA 441
E +L+AR++ + + W + + + E A
Sbjct: 1140 EVNEQLQARIKSLEKDSWRKASRSAAESA 1168
Score = 56.6 bits (135), Expect = 6e-08
Identities = 88/381 (23%), Positives = 166/381 (43%), Gaps = 66/381 (17%)
Query: 111 PKATVLQNQLDESQQERNDLMQLKLQLEGQVT----ELRSRVQELERALATARQEHTELM 166
P VL L E+++ ++++ K ++E Q+ EL + L+ +A+ QE +
Sbjct: 460 PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVR 519
Query: 167 EQYKG----ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 222
+QY+ + RS + T++ +L ++ A + L+ +++ SE+ + + +
Sbjct: 520 QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK 579
Query: 223 DTVKALTREQEKLLGQLKEVQADKEQSEAEL----EPLKEQLRGAQELAASSQQKATL-- 276
+ ++A +E L +++ +KE+ E EL E L+ +L A+ A ++Q L
Sbjct: 580 EDLRATKQE-------LLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKK 632
Query: 277 ----LGEELASAAAARD-RTIAELHRSR-----LEVAEVNGRLAELGLHLKEEKCQWSKE 326
EEL A R + +A HR R L V V A+ G L+E+ Q K
Sbjct: 633 ELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE---ADRGRELEEQNLQLQKT 689
Query: 327 RAGLLQSVE-AEKDKIL-KLSAEIL-----RLEKAVQEERTQNQVFKTEL---------- 369
L Q E A K K++ + A +L +E ++E + +N F+ +
Sbjct: 690 LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKET 749
Query: 370 -----------AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 418
AR +D L +L K++L E AL Q+E+ L K+ L + +
Sbjct: 750 RGLVDGGEAVEARLRDK-LQRLEAEKQQLEE---ALNASQEEEGSLAAAKRALEARLEEA 805
Query: 419 EARLEKVADEKWNEDATTEDE 439
+ L ++ E+ + E+E
Sbjct: 806 QRGLARLGQEQQTLNRALEEE 826
Score = 47.0 bits (110), Expect = 5e-05
Identities = 61/267 (22%), Positives = 119/267 (44%), Gaps = 37/267 (13%)
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
GE+T + + L R+ + V + +LE + ++ K E RL++
Sbjct: 362 GELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQEL------------ 409
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA---ARDRTIA 293
L+ + + +QS EL+ +K L ++L + + L +L A++ +
Sbjct: 410 --LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
Query: 294 ELHRSRLEVAEV--NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL-----KLSA 346
+L +R + EV + E L L+E + K G L+ A +D+ + +
Sbjct: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALK---GALKEEVASRDQEVEHVRQQYQR 524
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLV-----QLSESKRELTELRSALRVLQKEK 401
+ +L +++Q+ + V + E R+K S+LV +L E+ E +S + QK K
Sbjct: 525 DTEQLRRSMQDATQDHAVLEAE--RQKMSALVRGLQRELEETSEETGHWQS---MFQKNK 579
Query: 402 EQLQEEKQELLEYMRKLEARLEKVADE 428
E L+ KQELL+ + E E++ ++
Sbjct: 580 EDLRATKQELLQLRMEKEEMEEELGEK 606
Score = 39.7 bits (91), Expect = 0.008
Identities = 49/223 (21%), Positives = 98/223 (43%), Gaps = 11/223 (4%)
Query: 208 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELA 267
S K + + EL R V+ L R+ ++ + + ++++ + E +LE E+ QEL
Sbjct: 354 STKAVAGQGELTR---KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELL 410
Query: 268 ASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL--GLHLKEEKCQWSK 325
+ +A +EL + D+ H +V E+ +L + KE +
Sbjct: 411 ERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLL 470
Query: 326 ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKR 385
E LL+ V K ++ E LRL + +E K E+A + +R
Sbjct: 471 ETRELLEEVLEGKQRV----EEQLRLRE--RELTALKGALKEEVASRDQEVEHVRQQYQR 524
Query: 386 ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
+ +LR +++ ++ L+ E+Q++ +R L+ LE+ ++E
Sbjct: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEE 567
Score = 36.6 bits (83), Expect = 0.069
Identities = 43/185 (23%), Positives = 85/185 (45%), Gaps = 27/185 (14%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRV------QELERALATARQEHTELMEQY 169
L+ +L + + R DL K+ LE Q +L++R+ Q+ +L+ ++ L E+
Sbjct: 1002 LRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERL 1061
Query: 170 KGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 229
+ R + L R+ + +++ED+ Q +++ + D+L VKAL
Sbjct: 1062 QAEEREKTVLQSTNRKLERKVKE---LSIQIEDERQHVND-------QKDQLSLRVKALK 1111
Query: 230 R-------EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQE----LAASSQQKATLLG 278
R E E+L G K+ Q + E+ E L+ +++ ++ A+ S ++ L
Sbjct: 1112 RQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKN 1171
Query: 279 EELAS 283
E L+S
Sbjct: 1172 EGLSS 1176
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 75.9 bits (185), Expect = 1e-13
Identities = 76/333 (22%), Positives = 149/333 (44%), Gaps = 41/333 (12%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+ + + QQ+R + Q LQL+ ++ +L S++ E ER L A
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA----------------- 433
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKV---LTKEVELDRLRDTVKALTREQ 232
HG + E+R + S + D ++ +L+ + + E++ +T EL D K +EQ
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
Query: 233 EKL----LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLL---GEELASAA 285
+ L +L+E Q D EQ ++ ++++ + L S++ +LL E+L +
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKI 553
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
A + A L++ + + + ++ +L LK + + + L V+ +K +
Sbjct: 554 QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQ 613
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ-- 403
+L LE +V E +Q ++EK S L ++K EL A + Q+ Q
Sbjct: 614 DRVLSLETSVNELNSQ-----LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668
Query: 404 -------LQEEKQELLEYMRKLEARLEKVADEK 429
LQ+++QEL + +L+ K+ D++
Sbjct: 669 LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ 701
Score = 73.2 bits (178), Expect = 7e-13
Identities = 99/420 (23%), Positives = 185/420 (44%), Gaps = 55/420 (13%)
Query: 80 HTSVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLK----- 134
+ +Q QE +P D LVT A+ S L+ QL+E+Q E ++ Q+K
Sbjct: 116 YQGLQQQEAKP-DGLVTDSSAELQS-----------LEQQLEEAQTENFNIKQMKDLFEQ 163
Query: 135 --LQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGD 192
QL ++ +++S+ E A Q+ T L E+ + ++ E +L R +
Sbjct: 164 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE--LLQRPGIE 221
Query: 193 HVARILELEDDIQTISEKV-LTKEVELDRLRDTVKALTRE---QEKLLGQLKEVQADKEQ 248
VA + + +QT+ + + L +E E ++L+D K L + E + QL+ A Q
Sbjct: 222 DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 249 SEA----ELEPLKEQL-------RGAQELAASSQQKATLLGEELASAAAARDRTIAELHR 297
A EL+ LK + + E +Q T L E+ + ++ A LH+
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Query: 298 SRLEVAEVNGRL--AELGLH-LKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKA 354
L+ ++ RL +E LH + E + + L + + + K L AE K
Sbjct: 342 KDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF----KQ 397
Query: 355 VQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR-VLQKEKEQLQEEKQELLE 413
+Q++R + + +L E + +L E++R+L E L+ Q E+L +++Q++ +
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457
Query: 414 YMRKLEARLEKVADEKWNEDATTE----------DEEAAVGLSCPAALTDSEDESPEDMR 463
KL +RLE+ EK + E+ A+ S A L +++++ + +R
Sbjct: 458 LQLKL-SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Score = 70.1 bits (170), Expect = 6e-12
Identities = 87/389 (22%), Positives = 176/389 (45%), Gaps = 52/389 (13%)
Query: 110 VPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELER-------------ALA 156
V +T LQ+QLD+++Q+ + L+ ++ E ++ ++++ R AL
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 157 TARQEHTELMEQ-----YKGISRSHGEIT-----EERDILSRQQGDHVARILELEDDI-- 204
+E+ L+E+ Y I GE +E++ ++Q + L+ + +
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 205 ---QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLR 261
+ + ++V ++ L +D V +L +L QL E + Q + +++ E L
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 262 GAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRL-------AELGL 314
A+ AA + Q+A L + A +D+ EL++ ++ +V +L ++L
Sbjct: 653 SAE--AAKTAQRADLQNHLDTAQNALQDKQ-QELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRL----EKAVQEERTQNQVFK---- 366
HLKE K ++ L Q E + +I KL A+ L + E+A+Q+ + Q Q+
Sbjct: 710 HLKEYK----EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
Query: 367 --TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
TEL+++ + +S ++ +L + AL ++++ + +EEKQ L + L +
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
Query: 425 VADEKWNEDATTEDEEAAVGLSCPAALTD 453
+E N TT E V + A +T+
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTE 854
Score = 67.4 bits (163), Expect = 4e-11
Identities = 65/324 (20%), Positives = 147/324 (45%), Gaps = 28/324 (8%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+NQ + +Q + +L + + + + RV LE ++ + +++L E + +S+
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV---NELNSQLNESKEKVSQL 640
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
+I + ++L + A+ +L++ + T + K+ EL+++ T + +++
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI-------TTQLDQV 693
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 295
+L++ Q Q E+ L+ KE+ ++ + + L + A++++ + +L
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 296 HRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV 355
+ R ++ R EL L+ EK S R L + EA L + +L K
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA-------LESIKQKLTKQE 806
Query: 356 QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYM 415
+E++ Q F+T E+K + EL + ++ E ++++ EK+ L+ +
Sbjct: 807 EEKQILKQDFET-----------LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 416 RKLEARLEKVADEKWNEDATTEDE 439
++ +L KV+D N + E E
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKE 879
Score = 66.2 bits (160), Expect = 8e-11
Identities = 89/392 (22%), Positives = 166/392 (42%), Gaps = 60/392 (15%)
Query: 108 LVVPKATVLQNQLDESQQERN--DLMQLKLQLEGQVTELRSRVQ-------ELERALATA 158
L+ + T+ QN+ +E Q + N +L Q Q + Q+ L+ ++ ELE L
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 159 -RQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILEL---EDDIQTISEKVLTK 214
Q EL + + IS + ++ + Q D R EL D++++ EK+
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 215 EVELDRLRD-------------TVKA-LTREQEKLLGQLKE-------VQADKEQSEAEL 253
+ +L R+ T KA L ++ K QL+E +Q +K E EL
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1119
Query: 254 EPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL----EVAEVNGRL 309
K +L +E+ +++ T L EEL S + I L ++ + E+ G+
Sbjct: 1120 VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 310 AELGLHLKEEKCQWSKERAGLLQSVEAEKDKI--------LKLSAEILRLEKAVQEERTQ 361
L +++EK + + L V+ E++++ KL +EI E +++
Sbjct: 1180 DSLKAAVEQEK----RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235
Query: 362 NQVFKTELA----------REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL 411
++ +E SS ++SE +++ +LR + VL+ + Q+E++ L
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Query: 412 LEYMRKLEARLEKVADEKWNEDATTEDEEAAV 443
LE K E +EK+ + ++ AAV
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Score = 64.7 bits (156), Expect = 2e-10
Identities = 66/330 (20%), Positives = 139/330 (42%), Gaps = 16/330 (4%)
Query: 109 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
+V T++ N E ++E L +L+ Q + + +L LA QE +++
Sbjct: 230 LVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQE 289
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
+ + S E+T++ L+ +L+ E D + EK + V ++ T+
Sbjct: 290 LQKLKSSVNELTQKNQTLTE-------NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK 342
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAAR 288
+ ++L +L + + EL E + +E + + K L E R
Sbjct: 343 DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 348
+ + + E+ +++ +L E L E + ++R + + ++ ++ L ++
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 349 LRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEK 408
RLE+ ++E+ T + TEL + D + Q E + + LR Q + EQ+ +
Sbjct: 463 SRLEEQLKEKVTNS----TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Query: 409 QELLEYMRKLEARLEKVAD-----EKWNED 433
+ + ++ LEA L+K + EK ED
Sbjct: 519 GDKDQKIQNLEALLQKSKENISLLEKERED 548
Score = 62.4 bits (150), Expect = 1e-09
Identities = 86/355 (24%), Positives = 167/355 (47%), Gaps = 35/355 (9%)
Query: 117 QNQLDESQQERN------DLMQLKLQ-LEGQVTELRSRVQELERALATARQEHTELMEQY 169
QN L + QQE N D + KLQ + ++L S ++E + + Q+ EL Q
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 170 KGISRSHGEI--TEERDILSRQQG-----DHVARILELEDDIQTISEKVLTKEVELDRLR 222
K + E+ ++E+ + QQ D R EL ++ E V + ++L +
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 223 DTVKA----LTREQEKLLGQLKEVQADKEQSEAELEPLKEQLR-GAQELAASSQQKATLL 277
+ +++ LT+++E+ ++ + ++++ + E L +++ EL +K L+
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 278 GEELASAAAARDRTIAELHRSRLEVAEVN--GRLAELGLH--LKEEKCQWS-------KE 326
EL++ + L S+ E + N G+ A L L KE K Q KE
Sbjct: 853 -TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 327 RAGLLQSVEAEKDKILKLSAEILRL-EKAVQEERTQNQVFKTELAREKD-SSLVQLSESK 384
+ L +S+E EK+ +L E+ + E+ +Q + T Q K E + + + L Q SE K
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 385 RELTE-LRSALRVLQKEKEQLQEE-KQELLEYMRKLEARLEKVADEKWNEDATTE 437
++ E L+ L++ +K +L+ + +Q+L + ++L A EK++ + N + + E
Sbjct: 972 KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/362 (20%), Positives = 156/362 (43%), Gaps = 62/362 (17%)
Query: 112 KATVLQNQLDESQQE------------------RNDLMQLKLQLE----------GQVTE 143
K +VLQN ++SQ+ R DL ++ +L Q+
Sbjct: 1013 KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 144 LRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDD 203
+QEL+ A AT Q+ + +Q + ++ +I +E+ + ++ + +++ E+E+
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE- 1131
Query: 204 IQTISEKVLTKE------------VELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEA 251
I+ EK +TK E+ L+D + L +++ +L G+ ++A EQ +
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191
Query: 252 ELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAE 311
+ LK+Q++ +E + K + +E + +++ + E A++ ++
Sbjct: 1192 NQQILKDQVKKEEE-----ELKKEFIEKEAKLHSEIKEKEVGMKKHEENE-AKLTMQITA 1245
Query: 312 LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAR 371
L +L K +W + + + L+ + LR E AV E QN
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSE---------LEKQTDDLRGEIAVLEATVQNN------QD 1290
Query: 372 EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWN 431
E+ + L + + + E+ +L++ + LQ++ + QEL + L+ + + + KW
Sbjct: 1291 ERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWA 1350
Query: 432 ED 433
ED
Sbjct: 1351 ED 1352
Score = 60.1 bits (144), Expect = 6e-09
Identities = 80/406 (19%), Positives = 164/406 (40%), Gaps = 54/406 (13%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
++N L E ++ + L + K EL S ++L +A T +Q E + I+
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 964
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
+++ + QG+ +L+ + + +++ EL ++ + L EK
Sbjct: 965 KQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQ----------KATLLGEELASAA 285
K++Q+D E+EL ++ L+ +E + +Q+ L +EL +A
Sbjct: 1025 QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 286 AARDRTIA-------------------------ELHRSRLEVAEV-------NGRLAELG 313
A ++ A EL + ++AE+ + +L
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 314 LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 373
LK K + KE L + + + L+L + L+ AV++E+ Q+ K ++ +E+
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 374 DSSLVQLSESKRELTELRSALRVLQKEKE----QLQEEKQELLEYMRKLEARLEKVADE- 428
+ E K+E E + L KEKE + +E + +L + L L V E
Sbjct: 1205 E-------ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW 1257
Query: 429 KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGD 474
+ ++ +E E+ L A+ ++ ++ +D R C +G+
Sbjct: 1258 QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
Score = 57.4 bits (137), Expect = 4e-08
Identities = 92/406 (22%), Positives = 169/406 (41%), Gaps = 83/406 (20%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI--- 172
L Q +E Q + D L + + Q EL +R+Q L + E LM + +
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 173 -SRSHGEITEERDILSRQQGDHVARILELEDDIQTIS-----------------EKVLTK 214
S+ + + ++ A IL+LE + + +K L K
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK 921
Query: 215 EVE---------------LDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQ 259
E E L + ++T+K +E+++L G + E++ EQ + ++E L+ +
Sbjct: 922 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981
Query: 260 LRGA----QELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV-----AEVNGRLA 310
L+ A EL QQ+ T +ELA A + + + E ++ GR +
Sbjct: 982 LKIAVLQKTELENKLQQQLTQAAQELA-AEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040
Query: 311 EL-----GLHLKEEKCQWSKE-----------RAGLLQSVEAEKDKILKLSA----EILR 350
EL L EEK ++E + L+Q ++ K + + SA ++
Sbjct: 1041 ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 351 LEKAVQEERTQNQVFKTELAREKDSSLVQLSESK----RELTELRSALRVLQ----KEKE 402
KA+Q+ + + + + EL EK S L ++ E K +E+T+L L+ + KE
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEK-SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159
Query: 403 QLQEEKQELLEYMRKLEARLEK----VADEKWNE----DATTEDEE 440
L++ KQ L++ +L+ + + V EK N+ D ++EE
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1205
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/260 (25%), Positives = 114/260 (43%), Gaps = 34/260 (13%)
Query: 202 DDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG-QLKEVQADK--EQSEAELEPLKE 258
DD+ + ++V + L + + L +E EK G Q +E + D S AEL+ L++
Sbjct: 83 DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142
Query: 259 QLRGAQ-------ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAE 311
QL AQ ++ +QKA L E+A + D RS E AE ++
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-----ERSLREAAE--QKVTR 195
Query: 312 LGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAR 371
L L +E + LLQ E +LK E+++++ + + + +L
Sbjct: 196 LTEELNKEATVIQDLKTELLQRPGIEDVAVLK--KELVQVQTLMDNMTLERERESEKLKD 253
Query: 372 EKDSSLVQLSESKRELTELRSAL-----------RVLQKEK---EQLQEEKQELLEYMRK 417
E Q + S+ +++LRS L + LQK K +L ++ Q L E + K
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 418 LEARLEKVADEKWNEDATTE 437
E K+ +EK NE++ ++
Sbjct: 314 KEQDYTKL-EEKHNEESVSK 332
Score = 45.4 bits (106), Expect = 1e-04
Identities = 51/218 (23%), Positives = 96/218 (44%), Gaps = 21/218 (9%)
Query: 215 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKA 274
E L RD V L +E + L LKE + E+ + EL E+ +G Q+ A
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL----EKYQGLQQQEAKPDGLV 130
Query: 275 TLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 334
T EL S + E + + A+L + + K ++ +ER+
Sbjct: 131 TDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERS----LR 186
Query: 335 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL 394
EA + K+ +L+ E+ +E T Q KTEL + + ++ K+EL ++++ +
Sbjct: 187 EAAEQKVTRLTEEL-------NKEATVIQDLKTELLQR--PGIEDVAVLKKELVQVQTLM 237
Query: 395 RVL----QKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
+ ++E E+L++E ++L EA + ++ E
Sbjct: 238 DNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
Score = 33.5 bits (75), Expect = 0.58
Identities = 39/176 (22%), Positives = 72/176 (40%), Gaps = 21/176 (11%)
Query: 99 EADGGSDILLVVPKATVLQ---NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERAL 155
E G +D L KA V Q NQ Q + + +LK + + +L S ++E E +
Sbjct: 1174 ELQGKADSL----KAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 156 ATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKE 215
+ +L Q ++ + G + +E R R+ ELE + ++ E
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQR-------RVSELEKQTDDLRGEIAVLE 1282
Query: 216 VELDRLRDTVKALTR-------EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQ 264
+ +D +AL E EKL ++ E+Q + + A ++ L + + Q
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 74.7 bits (182), Expect = 2e-13
Identities = 81/324 (25%), Positives = 147/324 (45%), Gaps = 31/324 (9%)
Query: 116 LQNQLDESQ---QERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
LQ L+E + QE++DL QL+ L+ + +L+S + + + + EQ +
Sbjct: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM-------NIDTQEQLRNA 969
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRD-------TV 225
S + E + L + + V+R L +E++ ++ K V +D+ +D T+
Sbjct: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
Query: 226 KALTREQE---------KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATL 276
A ++ E L+ + E+Q E AE E LK L+ E+ +Q++ L
Sbjct: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 277 LGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEA 336
LG+EL + + E++ RLAE+ LK EK Q +E+ L +V+
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLLNVQE 1148
Query: 337 EKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRV 396
E ++ K EI L+ ++ + + +TE E L + E + +T+ R L+
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETE-RLELAQKLNENYEEVKSITKERKVLKE 1207
Query: 397 LQKEKEQLQEEKQELLEYMRKLEA 420
LQK + E+ L Y+R++EA
Sbjct: 1208 LQK---SFETERDHLRGYIREIEA 1228
Score = 63.9 bits (154), Expect = 4e-10
Identities = 81/341 (23%), Positives = 151/341 (44%), Gaps = 45/341 (13%)
Query: 112 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 171
K LQ + E Q+ N++ QLK QLE + + L++ E E+ L T + + T +E+ K
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT--VEREKTLITEKLQQT--LEEVK- 925
Query: 172 ISRSHGEITEERDILSRQQGDHVARILELEDDIQ-TISEKVLTKEVELDRLRDTVKALTR 230
+T+E+D L + Q +L+ DI T++ + T+E +LR+ +++L +
Sbjct: 926 ------TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQE----QLRNALESLKQ 975
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA-ARD 289
QE + ++ + ++ E E Q+ +K L + + A +D
Sbjct: 976 HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035
Query: 290 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
I E R + + L ++ L+SV AEK+++ E +
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQM------------------LESVIAEKEQLKTDLKENI 1077
Query: 350 RLEKAVQEE-RTQNQVFKTE---LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
+ QEE R K + +A+EK+ ++ + E R L L+++ +QLQ
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 406 EEKQELLEY------MRKLEARLEKVADEKWNEDATTEDEE 440
E++Q+LL M+K +E + +E N++ T E E
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME 1178
Score = 60.5 bits (145), Expect = 4e-09
Identities = 64/314 (20%), Positives = 141/314 (44%), Gaps = 48/314 (15%)
Query: 136 QLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 195
++E ++ E ++QE ++ L ++E +E+ ++ I E+ + L + + +
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183
Query: 196 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELE- 254
+L ++ + + K +TKE ++ L++ K+ E++ L G ++E++A Q++ EL+
Sbjct: 1184 LAQKLNENYEEV--KSITKERKV--LKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239
Query: 255 ---PLKEQLRGAQELAASSQQKATLL--GEELASAAAARDRTIAELHRSR------LEVA 303
LKE EL S +K + ++L + I LH + EV+
Sbjct: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 304 EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQ 363
E + EL L + QS + + ++ E LRL + QE + + +
Sbjct: 1300 ETQETMNELELLTE--------------QSTTKDSTTLARIEMERLRLNEKFQESQEEIK 1345
Query: 364 VFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 423
L +E+D+ L++ L+ + +QL+E +E L +++ +++ E
Sbjct: 1346 ----SLTKERDN--------------LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 424 KVADEKWNEDATTE 437
+ + K ++ TT+
Sbjct: 1388 QSLNMKEKDNETTK 1401
Score = 60.5 bits (145), Expect = 4e-09
Identities = 92/370 (24%), Positives = 153/370 (41%), Gaps = 58/370 (15%)
Query: 119 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGE 178
QL E QQ+ ++ + +++ ++ E+ + EL+ T TE +E + ++ ++ E
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
Query: 179 ---ITEERDILSRQQG------DHV-ARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
IT+ER +L Q DH+ I E+E E++ + L ++T+ L
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELA-----ASSQQKATLLGEELAS 283
R + Q+ Q D E+S +L+ L QEL S Q+ E L
Sbjct: 1255 RRSVSEKTAQIINTQ-DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTE 1313
Query: 284 AAAARDRT-IAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 342
+ +D T +A + RL RL E +EE +KER L EA + K
Sbjct: 1314 QSTTKDSTTLARIEMERL-------RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD 1366
Query: 343 KLSAEILRLEKAVQEERTQNQ---------------VFKTELAREKDSSLVQ-----LSE 382
+L I +QE +++ + V + E + KDS+L++ L
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGL 1426
Query: 383 SKR-------------ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 429
SKR E +L+ VLQ E +QL+E +E++ + E L KVA
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL-KVAHCC 1485
Query: 430 WNEDATTEDE 439
E T +E
Sbjct: 1486 LKEQEETINE 1495
Score = 60.5 bits (145), Expect = 4e-09
Identities = 68/308 (22%), Positives = 149/308 (48%), Gaps = 20/308 (6%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQ---VTELRSRVQELERALATARQEHTELMEQYKGI 172
L+ ++E+Q++ +++ QLK Q++ Q +++L L + L +E +M++ +
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVE--LDRLRDTVKALTR 230
R + ERD L + AR LE++ +++T ++L+KE + +D+LR+ + T
Sbjct: 1895 RRVEETLKLERDQLKESLQETKARDLEIQQELKT--ARMLSKEHKETVDKLREKISEKTI 1952
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDR 290
+ + L + + + ++ EL+ + QL +E S +K + E+L A++
Sbjct: 1953 QISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM-EQLKKQFEAQNL 2011
Query: 291 TIAELHRSRLEVA-EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEIL 349
++ + ++ +++ L E+ + KE E + +S++ E+D+ + E++
Sbjct: 2012 SMQSVRMDNFQLTKKLHESLEEIRIVAKER-----DELRRIKESLKMERDQFIATLREMI 2066
Query: 350 ---RLEKAVQEER---TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ 403
R V+ E+ + Q TE REK S + +L + E+ + L L + E+
Sbjct: 2067 ARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK 2126
Query: 404 LQEEKQEL 411
E ++EL
Sbjct: 2127 EIEFQKEL 2134
Score = 58.9 bits (141), Expect = 1e-08
Identities = 75/348 (21%), Positives = 159/348 (45%), Gaps = 36/348 (10%)
Query: 92 DELVTLEEA-DGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQE 150
D L T++EA + D L + T+ + Q +S+QE++ M+ K + + T++ S +++
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK---DNETTKIVSEMEQ 1408
Query: 151 LERALATARQEHTELMEQYKGISRSHGE---ITEERDILSRQQGDHVARILELEDDIQTI 207
+ + + E++ K + SH E + +E+D L R Q + +L+++I+ I
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468
Query: 208 SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQS----EAELEPLKEQLRG- 262
K L E EL +EQE+ + +L+ ++KE + +LE + ++L+
Sbjct: 1469 VAKHLETEEELK----VAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524
Query: 263 AQEL-----------AASSQQKATLLGEELASAAAARDRTIAELHRSRLEVA-EVNGRLA 310
QE+ + Q+K L ++ A+D + + LE+ +
Sbjct: 1525 IQEIYEKEEQFNIKQISEVQEKVNEL-KQFKEHRKAKDSALQSIESKMLELTNRLQESQE 1583
Query: 311 ELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELA 370
E+ + +KE+ +E + ++++ E+D++ + + EI+ K QE+ + Q K
Sbjct: 1584 EIQIMIKEK-----EEMKRVQEALQIERDQLKENTKEIVAKMKESQEK--EYQFLKMTAV 1636
Query: 371 REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 418
E + ++ K + + L ++ E +L + E LE MR +
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Score = 57.0 bits (136), Expect = 5e-08
Identities = 69/341 (20%), Positives = 147/341 (43%), Gaps = 41/341 (12%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEI 179
++E+Q++ ++ LK Q E Q L + +E Q E +E+ + +++ ++
Sbjct: 1636 VNETQEKMCEIEHLKEQFETQKLNL----ENIETENIRLTQILHENLEEMRSVTKERDDL 1691
Query: 180 TE-------ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE- 231
ERD L + + R LE +++++ + + + +D+LR V T E
Sbjct: 1692 RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI 1751
Query: 232 ----------QEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
+ L Q ++Q + + L+ +E + + + + K + + ++L
Sbjct: 1752 SNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL 1811
Query: 282 ASAAAARDRTIAELHRS-------RLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 334
++ A I EL + + +V E +++E+ E+ + K+++ L +
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM-----EQLKKQIKDQSLTLSKL 1866
Query: 335 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSAL 394
E E + + E L K+V +ER + + L E+D L E+K E++ L
Sbjct: 1867 EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 395 ---RVLQKEK----EQLQEEKQELLEYMRKLEARLEKVADE 428
R+L KE ++L+E+ E + ++ L+K DE
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
Score = 55.8 bits (133), Expect = 1e-07
Identities = 78/388 (20%), Positives = 163/388 (42%), Gaps = 60/388 (15%)
Query: 95 VTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERA 154
+TLE + ++ L + K ++ +ER L +L+ E + LR ++E+E
Sbjct: 1172 LTLEHME--TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEAT 1229
Query: 155 LATARQE----------HTELMEQYK--------------GISRSHGEITEERDILSRQQ 190
++E H E +++ + + +SH ++ EE +L +Q
Sbjct: 1230 GLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ 1289
Query: 191 G-----DHVARILELEDDIQTISEKVLTKE------VELDRLR---------DTVKALTR 230
V+ E ++++ ++E+ TK+ +E++RLR + +K+LT+
Sbjct: 1290 ELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK 1349
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE-----LASAA 285
E++ L + ++ +Q + E ++E L QE + +Q + ++ + S
Sbjct: 1350 ERDNLKTIKEALEVKHDQLK---EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEM 1406
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV-EAEKDKILKL 344
+ L R +E+ ++ RL E H + + K+ LQ V ++E D++ +
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQES--HDEMKSVAKEKDDLQRLQEVLQSESDQLKEN 1464
Query: 345 SAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQL 404
EI+ +EE E + V LSE + E++ ++ L + ++L
Sbjct: 1465 IKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN---DKL 1521
Query: 405 QEEKQELLEYMRKLEARLEKVADEKWNE 432
Q + QE+ E + + EK NE
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNE 1549
Score = 55.1 bits (131), Expect = 2e-07
Identities = 65/312 (20%), Positives = 138/312 (44%), Gaps = 23/312 (7%)
Query: 114 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS 173
TV + ES R++ ++LK +++ T + +++ + + ++ K +
Sbjct: 632 TVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ 691
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQE 233
+ EIT+ ++ + + LELE I T +K L KEVE + RE+
Sbjct: 692 SAFNEITKLTSLIDGKVPKDLLCNLELEGKI-TDLQKELNKEVEENE-------ALREEV 743
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
LL +LK + ++ E+ E++ E+L + S + K L E+ + +
Sbjct: 744 ILLSELKSLPSEVERLRKEIQDKSEEL----HIITSEKDK---LFSEVVHKESRVQGLLE 796
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEK---CQWSKERAGLLQSVEAEKDKILKLSAEILR 350
E+ +++ ++A + K + ++ +L+ E +I+ LS E +
Sbjct: 797 EIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
Query: 351 LEKAVQEERTQNQVFKT----ELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQE 406
+ ++ +T+ +KT E RE L ++ + K +L S L+ +++EK + E
Sbjct: 857 FDSSLGALKTELS-YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE 915
Query: 407 EKQELLEYMRKL 418
+ Q+ LE ++ L
Sbjct: 916 KLQQTLEEVKTL 927
Score = 48.9 bits (115), Expect = 1e-05
Identities = 71/315 (22%), Positives = 137/315 (43%), Gaps = 52/315 (16%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQY--KGISRSHG 177
L E ++ N+L + E +++ ++ +++ + L QE E EQ+ K IS
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQE 1545
Query: 178 EITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG 237
++ E + ++ A +Q+I K+L L ++ ++ + +E+E
Sbjct: 1546 KVNELKQFKEHRKAKDSA--------LQSIESKMLELTNRLQESQEEIQIMIKEKE---- 1593
Query: 238 QLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHR 297
++K VQ E + E + LKE + SQ+K + A
Sbjct: 1594 EMKRVQ---EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA--------------- 1635
Query: 298 SRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQE 357
V E ++ E+ HLKE Q+ ++ L+++E E ++ ++ E L ++V +
Sbjct: 1636 ----VNETQEKMCEIE-HLKE---QFETQKLN-LENIETENIRLTQILHENLEEMRSVTK 1686
Query: 358 ERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRK 417
ER + + L E+D QL E+ RE + R L+K+ E+L+ L E+
Sbjct: 1687 ERDDLRSVEETLKVERD----QLKENLRE-----TITRDLEKQ-EELKIVHMHLKEHQET 1736
Query: 418 LEARLEKVADEKWNE 432
++ +L + EK NE
Sbjct: 1737 ID-KLRGIVSEKTNE 1750
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/317 (20%), Positives = 127/317 (40%), Gaps = 51/317 (16%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRV----QELERALATARQEHTELMEQYKG 171
+Q + D Q N + + + TE R +E E+ L + ++++ +L + Y+
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348
Query: 172 ISRSHGEITEERDILSRQQGDHVA---------RILELEDDIQTISEKVLTKEVELDRLR 222
+ S + + HV +I ELE+ + E + KE ++ +++
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQ 2408
Query: 223 DTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELA 282
+E E + ++QA +S LE KE ++ Q+ A +
Sbjct: 2409 -------KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPY-------- 2453
Query: 283 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL 342
+ E+ ++ +L ++ L + ++ KE + +VE +K+ I
Sbjct: 2454 ----------------KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR 2497
Query: 343 KLSAEILRLEKA----VQEERTQNQVFKTELAREKDSSLVQLSES---KRELTELRSALR 395
L + R ++A V E T Q L S +VQ +++ K E L +
Sbjct: 2498 LLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
Query: 396 VLQKEKEQLQEEKQELL 412
L+++ EQL ++K ELL
Sbjct: 2558 KLKQQNEQLIKQKNELL 2574
Score = 47.0 bits (110), Expect = 5e-05
Identities = 65/361 (18%), Positives = 145/361 (40%), Gaps = 43/361 (11%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L+ ++ + +E + + K +L +V SRVQ L + + + YK
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD-- 816
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
+E D + + ++ + ++++++ E + ++ AL E
Sbjct: 817 -----QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYK 871
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL-------------- 281
+L+E + ++ E+E LKEQL + +++ TL+ E+L
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Query: 282 -------ASAAAARDRTIAELH---RSRLEVAE-VNGRLAELGLH---LKEEKCQWSKER 327
S RD+ +++H ++ E + L L H + K + S+E
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
Query: 328 AGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQ----LSES 383
+ L E + + +++ ++K E Q ++ KD+ +++ +
Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV---KDNEIIEQQRKIFSL 1048
Query: 384 KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE-KWNEDATTEDEEAA 442
+E EL+ L + EKEQL+ + +E +E + + L + DE K ++ +++ A
Sbjct: 1049 IQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHA 1108
Query: 443 V 443
+
Sbjct: 1109 I 1109
Score = 46.2 bits (108), Expect = 9e-05
Identities = 68/372 (18%), Positives = 154/372 (41%), Gaps = 61/372 (16%)
Query: 119 QLDESQQERNDLMQLK----------LQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
Q+ E Q++ N+L Q K +E ++ EL +R+QE +++E ++++
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE-------SQEEIQIMIKE 1591
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELED-------------------DIQTISE 209
+ + R + ERD L + VA++ E ++ +I+ + E
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
Query: 210 KVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADK-------EQSEAELEPLKEQLRG 262
+ T+++ L+ + LT+ + L +++ V ++ E + E + LKE LR
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRE 1711
Query: 263 AQELAASSQQKATLLGEELASAAAARDR-------TIAELHRSRLEVAEVNGRLAELGLH 315
Q++ ++ L D+ E+ + ++ N L L
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 316 LKEE------KCQWSKERAGLLQSVEAEK-DKILKLSAEILRLEKAVQEERTQNQVFKTE 368
++EE + +E L+ + +EK DK+ + ++ +QE+ + + + +
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 369 LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
L K ++E++++++E+ + ++ + L + + E L +KL LE++
Sbjct: 1832 LITLKK----DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSV 1887
Query: 429 KWNEDATTEDEE 440
D EE
Sbjct: 1888 MKERDNLRRVEE 1899
Score = 42.7 bits (99), Expect = 0.001
Identities = 78/394 (19%), Positives = 161/394 (40%), Gaps = 56/394 (14%)
Query: 88 PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR 147
P DE +T + + + P + ++ R ++M LK QLE L +R
Sbjct: 310 PVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEE--VSLETR 367
Query: 148 VQELERALATARQEHTELM-----EQYKGISR---SHGEITEERDI-------------- 185
Q +E+ E +L+ E+ + ++R + +T ++++
Sbjct: 368 AQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGK 427
Query: 186 LSRQQGDHVARILELEDDIQTISEKV---LTKEV------ELDRLRDTVKALTR------ 230
+++ + + A + +I T + K+ L +E+ E D +T+ L+
Sbjct: 428 INKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPA 487
Query: 231 ----EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA 286
QE + +L ++AD + + E L+ + +E+ ++K L E
Sbjct: 488 TKLLNQENIESELNSLRADYDNLVLDYEQLRTE---KEEMELKLKEKNDLDEFEALERKT 544
Query: 287 ARDRTIAELH-----RSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQS-VEAEKDK 340
+D+ + +H ++ ++ AEV + E L K E + +++ LQ ++++K +
Sbjct: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604
Query: 341 ILK--LSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQ 398
+K LS + +E Q ++T L +++S+ L EL E L
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF--LRSENLELKEKMKELATTY 662
Query: 399 KEKEQLQEEKQELLEYMRKLEARLEKVADEKWNE 432
K+ E + Q LE +K++ LEK +NE
Sbjct: 663 KQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 74.3 bits (181), Expect = 3e-13
Identities = 91/374 (24%), Positives = 165/374 (44%), Gaps = 28/374 (7%)
Query: 70 PESTTDGSPIHTSVQFQEPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERND 129
PE+TT G + + E + E I ++ + T LQ L SQ
Sbjct: 96 PETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVK- 154
Query: 130 LMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQ 189
QLEG+ +L SR+ + + Q + + Q K R E+T+ERD LS +
Sbjct: 155 ------QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 208
Query: 190 QGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR--EQEKLLGQLKEVQADKE 247
+ EL++ + EK+ E E ++ VK L R E+ KLL +++QA+ +
Sbjct: 209 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
EL+ + +L+ E + L ++ ++ I E ++ E
Sbjct: 269 HLGKELQSVSAKLQAQVE----ENELWNRLNQQQEEKMWRQEEKIQEWEE---KIQEQEE 321
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVF-K 366
++ E +EEK + +E+ + + EK++ ++ E++ EK + R + ++ K
Sbjct: 322 KIRE-----QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM-WEKEEKMRRQEEMMWEK 375
Query: 367 TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVA 426
E R ++ + + E REL E ++ ++EK + QEEK++ E +R+ E R E+ A
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEE-----KMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430
Query: 427 DEKWNEDATTEDEE 440
E+ E EE
Sbjct: 431 KMWRQEEKIREQEE 444
Score = 58.2 bits (139), Expect = 2e-08
Identities = 63/336 (18%), Positives = 158/336 (47%), Gaps = 31/336 (9%)
Query: 124 QQERNDLMQLKL-QLEGQVTELRSRVQELERALATARQE--------HTELMEQYKGISR 174
+QE+ + K+ + E ++ E +++E E+ + ++ E ++ + + R
Sbjct: 421 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 480
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL----DRLRDTVKALTR 230
+I E+ +I +++ H E E+ I+ EKV +E ++ +++R+ + + R
Sbjct: 481 QEEKIHEQEEIWRQKEKMH-----EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR 535
Query: 231 EQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDR 290
++EK+ Q +E+ ++E+ + + +E+ R QE Q++ EE + R
Sbjct: 536 QEEKIREQ-EEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594
Query: 291 TIAELHRSRLEVA---EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE 347
E + + E E R E + +EEK + +E+ + + E+++ + E
Sbjct: 595 EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
+ ++ +E+ + + E RE++ + + E RE E+ +Q+++E++ E+
Sbjct: 655 KMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM------MQEQEEKMWEQ 708
Query: 408 KQELLEYMRKLEARLEKV---ADEKWNEDATTEDEE 440
++++ E K++ + EK+ ++ W ++ +E
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744
Score = 57.8 bits (138), Expect = 3e-08
Identities = 66/335 (19%), Positives = 155/335 (46%), Gaps = 24/335 (7%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q ++ E +++R + +++ Q + Q E + QE + R++ ++ EQ K + R
Sbjct: 403 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-----IREQEEKIREQEKKMWRQE 457
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEV---ELDRLRDTVKALTREQE 233
+I E+ I ++ + E+ I E KE + +++R + + R++E
Sbjct: 458 EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE 517
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
K+ Q ++++ +E+ + E ++EQ +E +Q+ E+ R
Sbjct: 518 KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEE 577
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKE-EKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
++ +V ++ E +E E+ W +E + + +++KI + +I E
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQE-----EKIREQEEKIQEQEEKIREQE 632
Query: 353 KAV--QEERTQNQVFKT----ELAREKDSSLVQLSESK-RELTELRSALRVLQKEKEQLQ 405
+ + QEE TQ Q K E E++ + + E+ R+ ++R + +++++E+++
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 406 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
E+++ + E K+ + EK+ ++ E+ E EE
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQ---EEKMQEQEE 724
Score = 57.0 bits (136), Expect = 5e-08
Identities = 55/334 (16%), Positives = 148/334 (44%), Gaps = 15/334 (4%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
+E E+ + M+ + ++ + E R +E+ +E E M + + I +
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 414
Query: 181 EERDILSRQQG-DHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQL 239
EE I +++ + A++ E+ I+ EK+ +E ++ R + + EQEK+ +
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI----HEQEKIREEE 470
Query: 240 KEV-------QADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
K Q +K + E+ KE++ +E ++K E++
Sbjct: 471 KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQE 530
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
++ R ++ E E ++EK ++R + +++KI + ++ R E
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE 590
Query: 353 KAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELL 412
+ ++E+ + Q + ++ ++++ Q + + + ++R +++++E QE+++++
Sbjct: 591 EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 413 EYMRKL---EARLEKVADEKWNEDATTEDEEAAV 443
E K+ E ++++ + W ++ ++E +
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKI 684
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 74.3 bits (181), Expect = 3e-13
Identities = 85/353 (24%), Positives = 154/353 (43%), Gaps = 59/353 (16%)
Query: 122 ESQQERN-DLMQLKLQLEGQVTELRSRVQELERALATARQEH-------TELMEQYKGIS 173
E ++E N +L K +LE + +EL+ + +LE LA +E L E+ G+
Sbjct: 928 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD 987
Query: 174 RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA------ 227
+ ++T E+ L + + ED + ++++ E +++ L +++
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 1047
Query: 228 -LTREQEKLLGQLK-------EVQADKEQSEAELEP-------LKEQLRGAQELAASSQQ 272
L R + KL G LK +++ DK+Q + L+ L+ ++ Q L Q+
Sbjct: 1048 DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQK 1107
Query: 273 KATLLG---EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAG 329
K L EEL A T A+ + R + A L EL L+E AG
Sbjct: 1108 KIKELQARIEELEEEIEAERATRAKTEKQRSDYAR---ELEELSERLEE---------AG 1155
Query: 330 LLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTE 389
+ S + E +K K AE L+L + ++E Q++ L ++ S+ +L E
Sbjct: 1156 GVTSTQIELNK--KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ------ 1207
Query: 390 LRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED---ATTEDE 439
+ LQ+ K++L++EK E + L + +E V+ K N + T ED+
Sbjct: 1208 ----IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256
Score = 68.2 bits (165), Expect = 2e-11
Identities = 69/332 (20%), Positives = 150/332 (45%), Gaps = 34/332 (10%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
L + ++ + + +L ++ LE Q++E R + +E++R+L+ + + L + +SR
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR- 1290
Query: 176 HGEITEERDILSR---------QQGDHVARILELEDDIQ-TISEKVLTKEVELDRLRDTV 225
++ E+ I+S+ QQ + + R LE E+ + ++ + + + D LR+
Sbjct: 1291 --QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQY 1348
Query: 226 -----------KALTREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKA 274
+AL++ ++ + + D Q ELE K++L AQ L S+++
Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL--AQRL-QDSEEQV 1405
Query: 275 TLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELG---LHLKEEKCQWSKERAGLL 331
+ + AS + R E+ ++V N A L + + +W +
Sbjct: 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQ 1465
Query: 332 QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELR 391
+EA + LS E+ +L+ A +E Q + K RE + ++++ ++ E
Sbjct: 1466 AELEASLKESRSLSTELFKLKNAYEEALDQLETVK----RENKNLEQEIADLTEQIAENG 1521
Query: 392 SALRVLQKEKEQLQEEKQELLEYMRKLEARLE 423
+ L+K ++Q++ EK ++ + + EA LE
Sbjct: 1522 KTIHELEKSRKQIELEKADIQLALEEAEAALE 1553
Score = 64.7 bits (156), Expect = 2e-10
Identities = 74/338 (21%), Positives = 144/338 (42%), Gaps = 43/338 (12%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-- 173
+Q+ LD + RN+ ++LK ++EG + E+ ++ R A + + Q K
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 174 -----RSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
R ++ E+ I+ R+ A + EL ++ E EL + V+ L
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 229 TREQEKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL-----AS 283
+ L+ K+++ D Q ++E+E R A+E A + A ++ EEL S
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS 1777
Query: 284 AAAAR-----DRTIAEL-HR-----------SRLEVAEVNGRLAELGLHLKEEKCQWSKE 326
A R ++T+ +L HR + ++ ++ R+ EL L+ E+ + ++
Sbjct: 1778 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837
Query: 327 RAGLLQSVEAEKDKILKLSAE---ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 383
GL + K+ + + +LRL+ V + + + + +K + A E D ++
Sbjct: 1838 VKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQ-AEEAD------EQA 1890
Query: 384 KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 421
LT+ R A Q E E+ +E + KL A+
Sbjct: 1891 NAHLTKFRKA----QHELEEAEERADIAESQVNKLRAK 1924
Score = 62.8 bits (151), Expect = 9e-10
Identities = 79/367 (21%), Positives = 151/367 (41%), Gaps = 57/367 (15%)
Query: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQE-------LERALATARQEHTELMEQ 168
L Q+D Q+ + L + K + + ++ +L S ++ LE+ T + +E +
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAL 228
+ I RS E+T ++ L + G+ +S ++ KE + +L + +A
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGE--------------LSRQLEEKESIVSQLSRSKQAF 1309
Query: 229 TREQEKLLGQLKEVQADK-------EQSEAELEPLKEQLRGAQELAASSQQKATLLGEEL 281
T++ E+L QL+E K + S + + L+EQ QE A Q+ + E+
Sbjct: 1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1369
Query: 282 A---------------SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKE 326
A A+ + L S +V VN + A L++ K + E
Sbjct: 1370 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS----LEKTKQRLQGE 1425
Query: 327 RAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL---AREKDSSLVQLSES 383
L+ VE L + +K + E +T+ + + EL +E S +L +
Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485
Query: 384 KRELTELRSALRVLQKEKEQLQEEKQELLEY-------MRKLEARLEKVADEKWNEDATT 436
K E L +++E + L++E +L E + +LE +++ EK +
Sbjct: 1486 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545
Query: 437 EDEEAAV 443
E+ EAA+
Sbjct: 1546 EEAEAAL 1552
Score = 58.9 bits (141), Expect = 1e-08
Identities = 90/438 (20%), Positives = 178/438 (40%), Gaps = 94/438 (21%)
Query: 97 LEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALA 156
L+ A+ ++ + + +++L +S+ +R +L + + L + +L+ +VQ L
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL 900
Query: 157 TARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISE------- 209
A + +L++ + E+TE + + A+ +LED+ + +
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 210 --------------KVLTKEVELDRLRDTVKALTREQE---------------------- 233
KV EL L +T+ LTRE++
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020
Query: 234 ------KLLGQLKEVQADKEQSE---AELEPLKEQLRGAQELAASSQQKATLLGEELASA 284
KL Q++++++ EQ + +LE K +L G +LA S ++L
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 285 AAARDRTIAELHRSRLE------------VAEVNGRLAELGLHLKEEKCQWSK------- 325
+D +L +S++E + E+ R+ EL ++ E+ +K
Sbjct: 1081 LKKKDFEYCQL-QSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Query: 326 ------------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREK 373
E AG + S + E +K K AE L+L + ++E Q++ L ++
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNK--KREAEFLKLRRDLEEATLQHEAMVAALRKKH 1197
Query: 374 DSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVAD--E 428
S+ +L E ++ L+ + L+KEK + + E +L +E + K +A LEK+ E
Sbjct: 1198 ADSVAELGE---QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254
Query: 429 KWNEDATTEDEEAAVGLS 446
+A ++EE LS
Sbjct: 1255 DQLSEARGKNEEIQRSLS 1272
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/359 (21%), Positives = 154/359 (42%), Gaps = 24/359 (6%)
Query: 89 RPMDELVT-LEEADGGSDILLVVPKATV-----LQNQLDESQQERNDLMQ-LKLQLEGQV 141
R ++EL LEEA G + + + K L+ L+E+ + ++ L+ + V
Sbjct: 1142 RELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV 1201
Query: 142 TELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEER---DILSRQQGDHVARIL 198
EL ++ L+R +E +E + +S S +++ + + + R D ++
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR 1261
Query: 199 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQL-KEVQADKEQSEAELEPLK 257
++IQ ++ T++ L + E+E ++ QL + QA +Q+E L+
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Query: 258 EQLRGAQELA---ASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
E+ + LA SS+ LL E+ + L ++ EVA+ + +
Sbjct: 1322 EENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI 1381
Query: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
EE + K+ A LQ E +++ ++A+ LEK ++R Q +V + E+
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSE---EQVEAVNAKCASLEKT--KQRLQGEVEDLMVDVERA 1436
Query: 375 SSLVQLSESKRE-----LTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 428
+SL + K+ L E ++ Q E E +E + L + KL+ E+ D+
Sbjct: 1437 NSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Score = 53.5 bits (127), Expect = 5e-07
Identities = 60/325 (18%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 117 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
Q +L+ S +E L +L+ E +++ ++R QE +L EQ ++
Sbjct: 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524
Query: 177 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL 236
E+ + R + ++ D + E E ++ K+L ++EL +++ + E+++ +
Sbjct: 1525 HELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEI 1584
Query: 237 GQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELH 296
QLK + E ++ A + S+ +A L +++ + ++ +
Sbjct: 1585 EQLKR----------NYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHAN 1634
Query: 297 RSRLE----VAEVNGRLAELGLHLKE---------EKCQWSKERAGLLQSVEAEKDKILK 343
R E + V G+L + LHL + E+ + RA LLQ AE +++
Sbjct: 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ---AEVEELRA 1691
Query: 344 LSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES-KRELTELRSALRVLQKEKE 402
+ R K ++E + + +L +++SL+ + + +L +L+S + ++
Sbjct: 1692 TLEQTERARKLAEQELLDSNE-RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDAR 1750
Query: 403 QLQEEKQELLEYMRKLEARLEKVAD 427
+E+ ++ + + L+K D
Sbjct: 1751 NAEEKAKKAITDAAMMAEELKKEQD 1775
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/213 (21%), Positives = 97/213 (45%), Gaps = 8/213 (3%)
Query: 234 KLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
KL ++K + E +E E+ +KE+ + ++ A S+ K L E+L + ++
Sbjct: 832 KLFFKIKPLLKSAE-TEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEK 353
++ + + R +L + K Q + + + E E++ +L+A+ +LE
Sbjct: 891 QVQAESENLLDAEERCDQL----IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLED 946
Query: 354 AVQEERTQNQVFKTELAR---EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 410
E + + LA+ EK ++ ++ EL+ L + L +EK+ LQE Q+
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 411 LLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 443
L+ ++ E ++ + K + ED E+++
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL 1039
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/311 (24%), Positives = 141/311 (45%), Gaps = 33/311 (10%)
Query: 109 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
V + T L+ QL+E+ ++N L + +L+ + TE + ++E L + R + EL
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL--- 2240
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELE-DDIQTISEKVLTKEV---ELDRLRDT 224
S+ I E L + D+ R L+ E + ++ ++E+ V E RLR
Sbjct: 2241 ----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 225 VKALTREQ----EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
+ +Q EK+L + + + + +AE E L++Q AQE A Q+ + ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 281 LASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 340
LA RT+ + +LE++ R LK + S+ +A + + + +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAER-------LKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
++ ++ R E A QE+ T Q + +Q +S + LR A+ L++E
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLE-----------IQRQQSDHDAERLREAIAELERE 2458
Query: 401 KEQLQEEKQEL 411
KE+LQ+E + L
Sbjct: 2459 KEKLQQEAKLL 2469
Score = 69.7 bits (169), Expect = 7e-12
Identities = 76/330 (23%), Positives = 138/330 (41%), Gaps = 28/330 (8%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
A +Q + E QQ + QL G+ R +E E A A +E + Q +
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
R E+ +R Q A L E + E + E LR +A E
Sbjct: 2115 ERLKQSAEEQAQ--ARAQAQAAAEKLRKEAE----QEAARRAQAEQAALRQK-QAADAEM 2167
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
EK ++ K Q E EL L+ QL ++ L E AA R +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
EL R+++ E++ A + E + +++ + ++ E +K+ +++ E RL
Sbjct: 2228 EELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 353 KAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVLQKEKE------- 402
A QE Q+ + +LA+++ + L + ++ +E T L++ +LQ++KE
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 403 QLQEEKQELLE--------YMRKLEARLEK 424
+LQE+K+++ + + R LEA ++
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/362 (24%), Positives = 159/362 (43%), Gaps = 50/362 (13%)
Query: 84 QFQEPRPMDELVTLEEADGGSDILLVVPKATVLQN--QLDESQQERN-DLMQLKLQLEG- 139
Q + R V LE A ++ L +A+ + QL+ S QE + + QL+ + E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 140 --QVTELRSRVQELERAL---------ATARQEHTELMEQYKGISRSHGEIT-EERDILS 187
Q E +E ER L A + E + Q K ++++ E EE + +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 188 RQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 247
R++G + + Q + ++ L ++ EL++ R + +++ +L ++A+ E
Sbjct: 1674 RRRG---------KAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
Q E + + L+E+L Q AA++ QK L ELA A + +A R+
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA--------- 1774
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
EE+ + + E++ Q +EAE + +L+ E RL +E + Q Q+ +
Sbjct: 1775 ----------EEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 368 ELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+ AR++ + L+E E T L++ + KEKE E + L E RLE+
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 425 VA 426
A
Sbjct: 1883 QA 1884
Score = 67.4 bits (163), Expect = 4e-11
Identities = 106/457 (23%), Positives = 200/457 (43%), Gaps = 91/457 (19%)
Query: 86 QEPRPMDELVTL----EEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLE 138
Q+ + EL TL EE D ++L L KA + SQ E +L +++Q+E
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME 2238
Query: 139 GQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARIL 198
++++L++R++ RAL +++T+ Q + + ++ EE LS AR+
Sbjct: 2239 -ELSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLR 2294
Query: 199 EL-EDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQS- 249
+L E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 250 ------------------------EAELEPLK----EQLRG---AQELAASSQQKATLLG 278
AE E LK E R A+E A +++A +G
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 279 EELASAAAA--------------RDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEE 319
E+L A R ++ + R R +AE+ +L L LK E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 320 KCQWSK------ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQN 362
+ Q + E L QS +EKD +L+ + E +LE+ Q+E R +
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 363 QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARL 422
Q + ++ +E+ + + E++R E +R Q+E +QL++++++ E + + RL
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 423 E---KVADEKWNEDATTEDEEAAVGLSCPAALTDSED 456
++ +E+ +E A ++ L + D
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 30/336 (8%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DESQ++R Q +++L +V +E +RAL + + E + + ++ E+
Sbjct: 1505 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA--EVE 1558
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
R + + + EL+ + +EK E L V L E E+ Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
E + +E++E ELE + QL+ + L Q + + LA A A + + AE R
Sbjct: 1619 EAERAREEAERELE--RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 301 EVAEVNG-RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE------------ 347
AE R EL E++ Q ++ G Q A + ++++L AE
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAE---GTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 348 --ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
+ RL++ + Q + ELA+ + V L+ R E RS +K K++L+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRLE 1790
Query: 406 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 441
E E + + ARL +A+E + E++ A
Sbjct: 1791 AEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAA 1825
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 47/333 (14%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQE----LERALATARQEHTELMEQYKGISRS 175
L++ +Q Q K Q E + EL+ R+QE E A A+Q+ + E+ + + +S
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
E +I ++ + A L + +E+ + RL+ ++A R++
Sbjct: 1429 -----SEAEIQAKARQAEAAERSRLR----------IEEEIRVVRLQ--LEATERQRGGA 1471
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELAS-------AAAAR 288
G+L+ ++A E++EA+ +E+ + Q+ ELAS AA +
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAE 347
R + L RL+ E RL + + + + Q + E A +S EAE + K + +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEK 1588
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
+LE+++QEE V +L E + Q +E++R E ++E E+ Q +
Sbjct: 1589 TAQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLK 1637
Query: 408 KQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
E L +L + E+VA +K A E ++
Sbjct: 1638 ANEAL----RLRLQAEEVAQQKSLAQAEAEKQK 1666
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/304 (22%), Positives = 126/304 (41%), Gaps = 27/304 (8%)
Query: 120 LDESQQERN---DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+D QQ+R+ +L QL+ E ++ + + ER+ +E + Q + R
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 177 GEI----------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 226
G EE + RQ + R L +Q S++ EVEL
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 227 ALTREQEKLLGQLKEVQADKEQSEAELEPLK-EQLRGAQELAASSQQKATLLGEELASAA 285
RE+++ L L+E++ E++E L + E+ R Q ++Q+ A EL S
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE---AELQSKR 1582
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
A+ A+L RS E +L E E + Q E + E E ++ +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEA----ERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
E LRL +E Q + + E ++K+ + E++R A+R + +++L+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELE 1695
Query: 406 EEKQ 409
+++Q
Sbjct: 1696 KQRQ 1699
Score = 56.6 bits (135), Expect = 6e-08
Identities = 81/361 (22%), Positives = 152/361 (42%), Gaps = 21/361 (5%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+L ++ ++ R+ + K +LE + R +E R A A + + + +R
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E ER + + A L+ E +I + KE E +RLR + ++ +
Sbjct: 1827 QRAEA--ERVLAEKLAAIGEATRLKTEAEIA-----LKEKEAENERLRRLAEDEAFQRRR 1879
Query: 235 LLGQLKEVQADKEQSEAELEPLKE-QLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
L Q + +AD E+ A+L + +L + L + ++ + EE+ + A+ ++ A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEE-------KCQWSKERAGLLQSVEAEKDKILKLSA 346
LE+ + AE L KE+ + Q + E + E K L
Sbjct: 1940 GKAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ--- 403
E R KA EE + K E AR Q S + +L + + R+ +EK
Sbjct: 1999 EAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 404 LQEEKQELLEYMRKLEARLEKVADE-KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDM 462
+Q+++QEL + +++ ++ L+++ E + A E EEA V AA + + E E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 463 R 463
+
Sbjct: 2118 K 2118
Score = 53.9 bits (128), Expect = 4e-07
Identities = 80/345 (23%), Positives = 150/345 (43%), Gaps = 37/345 (10%)
Query: 123 SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEE 182
++Q N + +LQL +L ++ + E ++++Y + + E+T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVDLRTHYSELTT- 1328
Query: 183 RDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEV 242
L+ Q ++ L ++ + ++E+ +E E RL + V+A +Q +L +
Sbjct: 1329 ---LTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAE-VEAALEKQRQLAEAHAQA 1382
Query: 243 QADKEQSEAELEP-LKEQLRGAQELAASSQQKATLLGEEL-------ASAAAARDRTIAE 294
+A E+ EL+ ++E++ +E A +QQ+ + EEL + A+ R
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 295 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL--QSVEAEKDKILKLSAEILRLE 352
RSRL + E R+ L L E + ++ L ++ EAE K + E RL
Sbjct: 1443 AERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-RQAQEEAERLR 1500
Query: 353 KAVQEERTQNQVFKTEL----------AREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+ VQ+E + + + EL AREK +L L E + + E LR Q E E
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVE 1558
Query: 403 QLQEEKQELLEYMRKLEARLE----KVADEKWNEDATTEDEEAAV 443
+ ++ + L R EA L+ A++ + + ++E AV
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Score = 48.9 bits (115), Expect = 1e-05
Identities = 85/401 (21%), Positives = 156/401 (38%), Gaps = 96/401 (23%)
Query: 117 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 169
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 974 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 170 KGISRSHGEITEERD-ILSRQQGDHVARILELE-------------------DDIQTIS- 208
+G+ + ++ E + +L+ + A L E + ++TIS
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1093
Query: 209 --------EKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQL 260
E+VL E + V A E E LK+++A E + + L+++L
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 261 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR---LAELGLHL- 316
RGAQE+ QQ+ GE R+R L R + +A+ + R L +LG L
Sbjct: 1154 RGAQEVGERLQQRH---GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 317 ------------------KEEKCQ------------WSKERAGLLQSVEAEKDKILKLSA 346
++E+ Q ++ LL+ +E +K+ +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR 1270
Query: 347 EILRLEKAVQEERTQNQVFKTEL-----------AREKDSSLVQ----LSESKRELTELR 391
+ A+++ Q +K +L + S++Q L ELT L
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 392 S--------ALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
S LR +++E+ ++++ E E + ++EA LEK
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 49/219 (22%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+ Q+++ ++QQ R + + + Q+E QE +R +A+ + E +G+ R
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQME----------QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E+ ++ + RQQ E++L +E + RLR+ ++ L +
Sbjct: 2569 KQEEL-QQLEQQRRQQ------------------EELLAEENQ--RLREQLQLLEEQHRA 2607
Query: 235 LLGQLKEVQA----------------DKEQSEAELEPLKEQLRGAQELAASSQQKATLLG 278
L +EV A D +EAE E + LR ++++A Q+A +L
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR--RKVSAQRLQEAGILS 2665
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 317
E A T+ EL R + GR + GL LK
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/311 (24%), Positives = 141/311 (45%), Gaps = 33/311 (10%)
Query: 109 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
V + T L+ QL+E+ ++N L + +L+ + TE + ++E L + R + EL
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL--- 2244
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELE-DDIQTISEKVLTKEV---ELDRLRDT 224
S+ I E L + D+ R L+ E + ++ ++E+ V E RLR
Sbjct: 2245 ----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 225 VKALTREQ----EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
+ +Q EK+L + + + + +AE E L++Q AQE A Q+ + ++
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 281 LASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 340
LA RT+ + +LE++ R LK + S+ +A + + + +
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAER-------LKLRVAEMSRAQARAEEDAQRFRKQ 2413
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
++ ++ R E A QE+ T Q + +Q +S + LR A+ L++E
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLE-----------IQRQQSDHDAERLREAIAELERE 2462
Query: 401 KEQLQEEKQEL 411
KE+LQ+E + L
Sbjct: 2463 KEKLQQEAKLL 2473
Score = 69.7 bits (169), Expect = 7e-12
Identities = 76/330 (23%), Positives = 138/330 (41%), Gaps = 28/330 (8%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
A +Q + E QQ + QL G+ R +E E A A +E + Q +
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
R E+ +R Q A L E + E + E LR +A E
Sbjct: 2119 ERLKQSAEEQAQ--ARAQAQAAAEKLRKEAE----QEAARRAQAEQAALRQK-QAADAEM 2171
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
EK ++ K Q E EL L+ QL ++ L E AA R +
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
EL R+++ E++ A + E + +++ + ++ E +K+ +++ E RL
Sbjct: 2232 EELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 353 KAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVLQKEKE------- 402
A QE Q+ + +LA+++ + L + ++ +E T L++ +LQ++KE
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 403 QLQEEKQELLE--------YMRKLEARLEK 424
+LQE+K+++ + + R LEA ++
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/362 (24%), Positives = 159/362 (43%), Gaps = 50/362 (13%)
Query: 84 QFQEPRPMDELVTLEEADGGSDILLVVPKATVLQN--QLDESQQERN-DLMQLKLQLEG- 139
Q + R V LE A ++ L +A+ + QL+ S QE + + QL+ + E
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617
Query: 140 --QVTELRSRVQELERAL---------ATARQEHTELMEQYKGISRSHGEIT-EERDILS 187
Q E +E ER L A + E + Q K ++++ E EE + +
Sbjct: 1618 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Query: 188 RQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 247
R++G + + Q + ++ L ++ EL++ R + +++ +L ++A+ E
Sbjct: 1678 RRRG---------KAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
Q E + + L+E+L Q AA++ QK L ELA A + +A R+
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA--------- 1778
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
EE+ + + E++ Q +EAE + +L+ E RL +E + Q Q+ +
Sbjct: 1779 ----------EEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 368 ELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+ AR++ + L+E E T L++ + KEKE E + L E RLE+
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 425 VA 426
A
Sbjct: 1887 QA 1888
Score = 67.4 bits (163), Expect = 4e-11
Identities = 106/457 (23%), Positives = 200/457 (43%), Gaps = 91/457 (19%)
Query: 86 QEPRPMDELVTL----EEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLE 138
Q+ + EL TL EE D ++L L KA + SQ E +L +++Q+E
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME 2242
Query: 139 GQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARIL 198
++++L++R++ RAL +++T+ Q + + ++ EE LS AR+
Sbjct: 2243 -ELSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLR 2298
Query: 199 EL-EDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQS- 249
+L E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 250 ------------------------EAELEPLK----EQLRG---AQELAASSQQKATLLG 278
AE E LK E R A+E A +++A +G
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 279 EELASAAAA--------------RDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEE 319
E+L A R ++ + R R +AE+ +L L LK E
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478
Query: 320 KCQWSK------ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQN 362
+ Q + E L QS +EKD +L+ + E +LE+ Q+E R +
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538
Query: 363 QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARL 422
Q + ++ +E+ + + E++R E +R Q+E +QL++++++ E + + RL
Sbjct: 2539 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Query: 423 E---KVADEKWNEDATTEDEEAAVGLSCPAALTDSED 456
++ +E+ +E A ++ L + D
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 30/336 (8%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DESQ++R Q +++L +V +E +RAL + + E + + ++ E+
Sbjct: 1509 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA--EVE 1562
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
R + + + EL+ + +EK E L V L E E+ Q
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
E + +E++E ELE + QL+ + L Q + + LA A A + + AE R
Sbjct: 1623 EAERAREEAERELE--RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 301 EVAEVNG-RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE------------ 347
AE R EL E++ Q ++ G Q A + ++++L AE
Sbjct: 1681 GKAEEQAVRQRELAEQELEKQRQLAE---GTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Query: 348 --ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
+ RL++ + Q + ELA+ + V L+ R E RS +K K++L+
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRLE 1794
Query: 406 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 441
E E + + ARL +A+E + E++ A
Sbjct: 1795 AEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAA 1829
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 47/333 (14%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQE----LERALATARQEHTELMEQYKGISRS 175
L++ +Q Q K Q E + EL+ R+QE E A A+Q+ + E+ + + +S
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
E +I ++ + A L + +E+ + RL+ ++A R++
Sbjct: 1433 -----SEAEIQAKARQAEAAERSRLR----------IEEEIRVVRLQ--LEATERQRGGA 1475
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELAS-------AAAAR 288
G+L+ ++A E++EA+ +E+ + Q+ ELAS AA +
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAE 347
R + L RL+ E RL + + + + Q + E A +S EAE + K + +
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEK 1592
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
+LE+++QEE V +L E + Q +E++R E ++E E+ Q +
Sbjct: 1593 TAQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLK 1641
Query: 408 KQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
E L +L + E+VA +K A E ++
Sbjct: 1642 ANEAL----RLRLQAEEVAQQKSLAQAEAEKQK 1670
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/304 (22%), Positives = 126/304 (41%), Gaps = 27/304 (8%)
Query: 120 LDESQQERN---DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+D QQ+R+ +L QL+ E ++ + + ER+ +E + Q + R
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472
Query: 177 GEI----------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 226
G EE + RQ + R L +Q S++ EVEL
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVELASRVKAEA 1529
Query: 227 ALTREQEKLLGQLKEVQADKEQSEAELEPLK-EQLRGAQELAASSQQKATLLGEELASAA 285
RE+++ L L+E++ E++E L + E+ R Q ++Q+ A EL S
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE---AELQSKR 1586
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
A+ A+L RS E +L E E + Q E + E E ++ +
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEA----ERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
E LRL +E Q + + E ++K+ + E++R A+R + +++L+
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELE 1699
Query: 406 EEKQ 409
+++Q
Sbjct: 1700 KQRQ 1703
Score = 56.6 bits (135), Expect = 6e-08
Identities = 81/361 (22%), Positives = 152/361 (42%), Gaps = 21/361 (5%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+L ++ ++ R+ + K +LE + R +E R A A + + + +R
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E ER + + A L+ E +I + KE E +RLR + ++ +
Sbjct: 1831 QRAEA--ERVLAEKLAAIGEATRLKTEAEIA-----LKEKEAENERLRRLAEDEAFQRRR 1883
Query: 235 LLGQLKEVQADKEQSEAELEPLKE-QLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
L Q + +AD E+ A+L + +L + L + ++ + EE+ + A+ ++ A
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEE-------KCQWSKERAGLLQSVEAEKDKILKLSA 346
LE+ + AE L KE+ + Q + E + E K L
Sbjct: 1944 GKAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ--- 403
E R KA EE + K E AR Q S + +L + + R+ +EK
Sbjct: 2003 EAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 404 LQEEKQELLEYMRKLEARLEKVADE-KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDM 462
+Q+++QEL + +++ ++ L+++ E + A E EEA V AA + + E E +
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 463 R 463
+
Sbjct: 2122 K 2122
Score = 53.9 bits (128), Expect = 4e-07
Identities = 80/345 (23%), Positives = 150/345 (43%), Gaps = 37/345 (10%)
Query: 123 SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEE 182
++Q N + +LQL +L ++ + E ++++Y + + E+T
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVDLRTHYSELTT- 1332
Query: 183 RDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEV 242
L+ Q ++ L ++ + ++E+ +E E RL + V+A +Q +L +
Sbjct: 1333 ---LTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAE-VEAALEKQRQLAEAHAQA 1386
Query: 243 QADKEQSEAELEP-LKEQLRGAQELAASSQQKATLLGEEL-------ASAAAARDRTIAE 294
+A E+ EL+ ++E++ +E A +QQ+ + EEL + A+ R
Sbjct: 1387 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 295 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL--QSVEAEKDKILKLSAEILRLE 352
RSRL + E R+ L L E + ++ L ++ EAE K + E RL
Sbjct: 1447 AERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-RQAQEEAERLR 1504
Query: 353 KAVQEERTQNQVFKTEL----------AREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+ VQ+E + + + EL AREK +L L E + + E LR Q E E
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVE 1562
Query: 403 QLQEEKQELLEYMRKLEARLE----KVADEKWNEDATTEDEEAAV 443
+ ++ + L R EA L+ A++ + + ++E AV
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Score = 48.9 bits (115), Expect = 1e-05
Identities = 85/401 (21%), Positives = 156/401 (38%), Gaps = 96/401 (23%)
Query: 117 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 169
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 978 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1037
Query: 170 KGISRSHGEITEERD-ILSRQQGDHVARILELE-------------------DDIQTIS- 208
+G+ + ++ E + +L+ + A L E + ++TIS
Sbjct: 1038 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1097
Query: 209 --------EKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQL 260
E+VL E + V A E E LK+++A E + + L+++L
Sbjct: 1098 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1157
Query: 261 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR---LAELGLHL- 316
RGAQE+ QQ+ GE R+R L R + +A+ + R L +LG L
Sbjct: 1158 RGAQEVGERLQQRH---GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214
Query: 317 ------------------KEEKCQ------------WSKERAGLLQSVEAEKDKILKLSA 346
++E+ Q ++ LL+ +E +K+ +
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR 1274
Query: 347 EILRLEKAVQEERTQNQVFKTEL-----------AREKDSSLVQ----LSESKRELTELR 391
+ A+++ Q +K +L + S++Q L ELT L
Sbjct: 1275 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1334
Query: 392 S--------ALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
S LR +++E+ ++++ E E + ++EA LEK
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 49/219 (22%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+ Q+++ ++QQ R + + + Q+E QE +R +A+ + E +G+ R
Sbjct: 2523 LFQDEVAKAQQLREEQQRQQQQME----------QERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E+ ++ + RQQ E++L +E + RLR+ ++ L +
Sbjct: 2573 KQEEL-QQLEQQRRQQ------------------EELLAEENQ--RLREQLQLLEEQHRA 2611
Query: 235 LLGQLKEVQA----------------DKEQSEAELEPLKEQLRGAQELAASSQQKATLLG 278
L +EV A D +EAE E + LR ++++A Q+A +L
Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR--RKVSAQRLQEAGILS 2669
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 317
E A T+ EL R + GR + GL LK
Sbjct: 2670 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2708
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/311 (24%), Positives = 141/311 (45%), Gaps = 33/311 (10%)
Query: 109 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
V + T L+ QL+E+ ++N L + +L+ + TE + ++E L + R + EL
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL--- 2240
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELE-DDIQTISEKVLTKEV---ELDRLRDT 224
S+ I E L + D+ R L+ E + ++ ++E+ V E RLR
Sbjct: 2241 ----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 225 VKALTREQ----EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
+ +Q EK+L + + + + +AE E L++Q AQE A Q+ + ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 281 LASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 340
LA RT+ + +LE++ R LK + S+ +A + + + +
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAER-------LKLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
++ ++ R E A QE+ T Q + +Q +S + LR A+ L++E
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLE-----------IQRQQSDHDAERLREAIAELERE 2458
Query: 401 KEQLQEEKQEL 411
KE+LQ+E + L
Sbjct: 2459 KEKLQQEAKLL 2469
Score = 69.7 bits (169), Expect = 7e-12
Identities = 76/330 (23%), Positives = 138/330 (41%), Gaps = 28/330 (8%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
A +Q + E QQ + QL G+ R +E E A A +E + Q +
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
R E+ +R Q A L E + E + E LR +A E
Sbjct: 2115 ERLKQSAEEQAQ--ARAQAQAAAEKLRKEAE----QEAARRAQAEQAALRQK-QAADAEM 2167
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
EK ++ K Q E EL L+ QL ++ L E AA R +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
EL R+++ E++ A + E + +++ + ++ E +K+ +++ E RL
Sbjct: 2228 EELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 353 KAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVLQKEKE------- 402
A QE Q+ + +LA+++ + L + ++ +E T L++ +LQ++KE
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 403 QLQEEKQELLE--------YMRKLEARLEK 424
+LQE+K+++ + + R LEA ++
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/362 (24%), Positives = 159/362 (43%), Gaps = 50/362 (13%)
Query: 84 QFQEPRPMDELVTLEEADGGSDILLVVPKATVLQN--QLDESQQERN-DLMQLKLQLEG- 139
Q + R V LE A ++ L +A+ + QL+ S QE + + QL+ + E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 140 --QVTELRSRVQELERAL---------ATARQEHTELMEQYKGISRSHGEIT-EERDILS 187
Q E +E ER L A + E + Q K ++++ E EE + +
Sbjct: 1614 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 188 RQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 247
R++G + + Q + ++ L ++ EL++ R + +++ +L ++A+ E
Sbjct: 1674 RRRG---------KAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
Q E + + L+E+L Q AA++ QK L ELA A + +A R+
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA--------- 1774
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
EE+ + + E++ Q +EAE + +L+ E RL +E + Q Q+ +
Sbjct: 1775 ----------EEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 368 ELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+ AR++ + L+E E T L++ + KEKE E + L E RLE+
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 425 VA 426
A
Sbjct: 1883 QA 1884
Score = 67.4 bits (163), Expect = 4e-11
Identities = 106/457 (23%), Positives = 200/457 (43%), Gaps = 91/457 (19%)
Query: 86 QEPRPMDELVTL----EEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLE 138
Q+ + EL TL EE D ++L L KA + SQ E +L +++Q+E
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME 2238
Query: 139 GQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARIL 198
++++L++R++ RAL +++T+ Q + + ++ EE LS AR+
Sbjct: 2239 -ELSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLR 2294
Query: 199 EL-EDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQS- 249
+L E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 250 ------------------------EAELEPLK----EQLRG---AQELAASSQQKATLLG 278
AE E LK E R A+E A +++A +G
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 279 EELASAAAA--------------RDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEE 319
E+L A R ++ + R R +AE+ +L L LK E
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474
Query: 320 KCQWSK------ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQN 362
+ Q + E L QS +EKD +L+ + E +LE+ Q+E R +
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534
Query: 363 QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARL 422
Q + ++ +E+ + + E++R E +R Q+E +QL++++++ E + + RL
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 423 E---KVADEKWNEDATTEDEEAAVGLSCPAALTDSED 456
++ +E+ +E A ++ L + D
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 30/336 (8%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DESQ++R Q +++L +V +E +RAL + + E + + ++ E+
Sbjct: 1505 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA--EVE 1558
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
R + + + EL+ + +EK E L V L E E+ Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
E + +E++E ELE + QL+ + L Q + + LA A A + + AE R
Sbjct: 1619 EAERAREEAERELE--RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 301 EVAEVNG-RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE------------ 347
AE R EL E++ Q ++ G Q A + ++++L AE
Sbjct: 1677 GKAEEQAVRQRELAEQELEKQRQLAE---GTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 348 --ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
+ RL++ + Q + ELA+ + V L+ R E RS +K K++L+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRLE 1790
Query: 406 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 441
E E + + ARL +A+E + E++ A
Sbjct: 1791 AEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAA 1825
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 47/333 (14%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQE----LERALATARQEHTELMEQYKGISRS 175
L++ +Q Q K Q E + EL+ R+QE E A A+Q+ + E+ + + +S
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
E +I ++ + A L + +E+ + RL+ ++A R++
Sbjct: 1429 -----SEAEIQAKARQAEAAERSRLR----------IEEEIRVVRLQ--LEATERQRGGA 1471
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELAS-------AAAAR 288
G+L+ ++A E++EA+ +E+ + Q+ ELAS AA +
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAE 347
R + L RL+ E RL + + + + Q + E A +S EAE + K + +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEK 1588
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
+LE+++QEE V +L E + Q +E++R E ++E E+ Q +
Sbjct: 1589 TAQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLK 1637
Query: 408 KQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
E L +L + E+VA +K A E ++
Sbjct: 1638 ANEAL----RLRLQAEEVAQQKSLAQAEAEKQK 1666
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/304 (22%), Positives = 126/304 (41%), Gaps = 27/304 (8%)
Query: 120 LDESQQERN---DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+D QQ+R+ +L QL+ E ++ + + ER+ +E + Q + R
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468
Query: 177 GEI----------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 226
G EE + RQ + R L +Q S++ EVEL
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 227 ALTREQEKLLGQLKEVQADKEQSEAELEPLK-EQLRGAQELAASSQQKATLLGEELASAA 285
RE+++ L L+E++ E++E L + E+ R Q ++Q+ A EL S
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE---AELQSKR 1582
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
A+ A+L RS E +L E E + Q E + E E ++ +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEA----ERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
E LRL +E Q + + E ++K+ + E++R A+R + +++L+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELE 1695
Query: 406 EEKQ 409
+++Q
Sbjct: 1696 KQRQ 1699
Score = 56.6 bits (135), Expect = 6e-08
Identities = 81/361 (22%), Positives = 152/361 (42%), Gaps = 21/361 (5%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+L ++ ++ R+ + K +LE + R +E R A A + + + +R
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E ER + + A L+ E +I + KE E +RLR + ++ +
Sbjct: 1827 QRAEA--ERVLAEKLAAIGEATRLKTEAEIA-----LKEKEAENERLRRLAEDEAFQRRR 1879
Query: 235 LLGQLKEVQADKEQSEAELEPLKE-QLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
L Q + +AD E+ A+L + +L + L + ++ + EE+ + A+ ++ A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEE-------KCQWSKERAGLLQSVEAEKDKILKLSA 346
LE+ + AE L KE+ + Q + E + E K L
Sbjct: 1940 GKAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ--- 403
E R KA EE + K E AR Q S + +L + + R+ +EK
Sbjct: 1999 EAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 404 LQEEKQELLEYMRKLEARLEKVADE-KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDM 462
+Q+++QEL + +++ ++ L+++ E + A E EEA V AA + + E E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 463 R 463
+
Sbjct: 2118 K 2118
Score = 53.9 bits (128), Expect = 4e-07
Identities = 80/345 (23%), Positives = 150/345 (43%), Gaps = 37/345 (10%)
Query: 123 SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEE 182
++Q N + +LQL +L ++ + E ++++Y + + E+T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVDLRTHYSELTT- 1328
Query: 183 RDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEV 242
L+ Q ++ L ++ + ++E+ +E E RL + V+A +Q +L +
Sbjct: 1329 ---LTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAE-VEAALEKQRQLAEAHAQA 1382
Query: 243 QADKEQSEAELEP-LKEQLRGAQELAASSQQKATLLGEEL-------ASAAAARDRTIAE 294
+A E+ EL+ ++E++ +E A +QQ+ + EEL + A+ R
Sbjct: 1383 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 295 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL--QSVEAEKDKILKLSAEILRLE 352
RSRL + E R+ L L E + ++ L ++ EAE K + E RL
Sbjct: 1443 AERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-RQAQEEAERLR 1500
Query: 353 KAVQEERTQNQVFKTEL----------AREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+ VQ+E + + + EL AREK +L L E + + E LR Q E E
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVE 1558
Query: 403 QLQEEKQELLEYMRKLEARLE----KVADEKWNEDATTEDEEAAV 443
+ ++ + L R EA L+ A++ + + ++E AV
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Score = 48.9 bits (115), Expect = 1e-05
Identities = 85/401 (21%), Positives = 156/401 (38%), Gaps = 96/401 (23%)
Query: 117 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 169
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 974 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 170 KGISRSHGEITEERD-ILSRQQGDHVARILELE-------------------DDIQTIS- 208
+G+ + ++ E + +L+ + A L E + ++TIS
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1093
Query: 209 --------EKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQL 260
E+VL E + V A E E LK+++A E + + L+++L
Sbjct: 1094 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 261 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR---LAELGLHL- 316
RGAQE+ QQ+ GE R+R L R + +A+ + R L +LG L
Sbjct: 1154 RGAQEVGERLQQRH---GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 317 ------------------KEEKCQ------------WSKERAGLLQSVEAEKDKILKLSA 346
++E+ Q ++ LL+ +E +K+ +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR 1270
Query: 347 EILRLEKAVQEERTQNQVFKTEL-----------AREKDSSLVQ----LSESKRELTELR 391
+ A+++ Q +K +L + S++Q L ELT L
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 392 S--------ALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
S LR +++E+ ++++ E E + ++EA LEK
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 49/219 (22%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+ Q+++ ++QQ R + + + Q+E QE +R +A+ + E +G+ R
Sbjct: 2519 LFQDEVAKAQQLREEQQRQQQQME----------QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E+ ++ + RQQ E++L +E + RLR+ ++ L +
Sbjct: 2569 KQEEL-QQLEQQRRQQ------------------EELLAEENQ--RLREQLQLLEEQHRA 2607
Query: 235 LLGQLKEVQA----------------DKEQSEAELEPLKEQLRGAQELAASSQQKATLLG 278
L +EV A D +EAE E + LR ++++A Q+A +L
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR--RKVSAQRLQEAGILS 2665
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 317
E A T+ EL R + GR + GL LK
Sbjct: 2666 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/311 (24%), Positives = 141/311 (45%), Gaps = 33/311 (10%)
Query: 109 VVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ 168
V + T L+ QL+E+ ++N L + +L+ + TE + ++E L + R + EL
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL--- 2208
Query: 169 YKGISRSHGEITEERDILSRQQGDHVARILELE-DDIQTISEKVLTKEV---ELDRLRDT 224
S+ I E L + D+ R L+ E + ++ ++E+ V E RLR
Sbjct: 2209 ----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 225 VKALTREQ----EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEE 280
+ +Q EK+L + + + + +AE E L++Q AQE A Q+ + ++
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2324
Query: 281 LASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDK 340
LA RT+ + +LE++ R LK + S+ +A + + + +
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAER-------LKLRVAEMSRAQARAEEDAQRFRKQ 2377
Query: 341 ILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 400
++ ++ R E A QE+ T Q + +Q +S + LR A+ L++E
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLE-----------IQRQQSDHDAERLREAIAELERE 2426
Query: 401 KEQLQEEKQEL 411
KE+LQ+E + L
Sbjct: 2427 KEKLQQEAKLL 2437
Score = 69.7 bits (169), Expect = 7e-12
Identities = 76/330 (23%), Positives = 138/330 (41%), Gaps = 28/330 (8%)
Query: 113 ATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI 172
A +Q + E QQ + QL G+ R +E E A A +E + Q +
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082
Query: 173 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ 232
R E+ +R Q A L E + E + E LR +A E
Sbjct: 2083 ERLKQSAEEQAQ--ARAQAQAAAEKLRKEAE----QEAARRAQAEQAALRQK-QAADAEM 2135
Query: 233 EKLLGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTI 292
EK ++ K Q E EL L+ QL ++ L E AA R +
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE 352
EL R+++ E++ A + E + +++ + ++ E +K+ +++ E RL
Sbjct: 2196 EELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 353 KAVQEERTQNQVFKTELAREK---DSSLVQLSESKRELTELRSALRVLQKEKE------- 402
A QE Q+ + +LA+++ + L + ++ +E T L++ +LQ++KE
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 403 QLQEEKQELLE--------YMRKLEARLEK 424
+LQE+K+++ + + R LEA ++
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Score = 68.6 bits (166), Expect = 2e-11
Identities = 88/362 (24%), Positives = 159/362 (43%), Gaps = 50/362 (13%)
Query: 84 QFQEPRPMDELVTLEEADGGSDILLVVPKATVLQN--QLDESQQERN-DLMQLKLQLEG- 139
Q + R V LE A ++ L +A+ + QL+ S QE + + QL+ + E
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581
Query: 140 --QVTELRSRVQELERAL---------ATARQEHTELMEQYKGISRSHGEIT-EERDILS 187
Q E +E ER L A + E + Q K ++++ E EE + +
Sbjct: 1582 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Query: 188 RQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKE 247
R++G + + Q + ++ L ++ EL++ R + +++ +L ++A+ E
Sbjct: 1642 RRRG---------KAEEQAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 248 QSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG 307
Q E + + L+E+L Q AA++ QK L ELA A + +A R+
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA--------- 1742
Query: 308 RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 367
EE+ + + E++ Q +EAE + +L+ E RL +E + Q Q+ +
Sbjct: 1743 ----------EEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 368 ELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
+ AR++ + L+E E T L++ + KEKE E + L E RLE+
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 425 VA 426
A
Sbjct: 1851 QA 1852
Score = 67.4 bits (163), Expect = 4e-11
Identities = 106/457 (23%), Positives = 200/457 (43%), Gaps = 91/457 (19%)
Query: 86 QEPRPMDELVTL----EEADGGSDIL---LVVPKATVLQNQLDESQQERNDLMQLKLQLE 138
Q+ + EL TL EE D ++L L KA + SQ E +L +++Q+E
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE-ELFSVRVQME 2206
Query: 139 GQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARIL 198
++++L++R++ RAL +++T+ Q + + ++ EE LS AR+
Sbjct: 2207 -ELSKLKARIEAENRALILRDKDNTQRFLQEE--AEKMKQVAEEAARLS-VAAQEAARLR 2262
Query: 199 EL-EDDI---QTISEKVLTKEV----ELDRLRDTVKALTREQEKLLGQLKEVQADKEQS- 249
+L E+D+ + ++EK+L +++ E RL+ + L +++E Q + +Q DKEQ
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 250 ------------------------EAELEPLK----EQLRG---AQELAASSQQKATLLG 278
AE E LK E R A+E A +++A +G
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 279 EELASAAAA--------------RDRTIAELHRSRLEVAEVNGRLAELG-----LHLKEE 319
E+L A R ++ + R R +AE+ +L L LK E
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442
Query: 320 KCQWSK------ERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEE-------RTQN 362
+ Q + E L QS +EKD +L+ + E +LE+ Q+E R +
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502
Query: 363 QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARL 422
Q + ++ +E+ + + E++R E +R Q+E +QL++++++ E + + RL
Sbjct: 2503 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Query: 423 E---KVADEKWNEDATTEDEEAAVGLSCPAALTDSED 456
++ +E+ +E A ++ L + D
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 30/336 (8%)
Query: 121 DESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEIT 180
DESQ++R Q +++L +V +E +RAL + + E + + ++ E+
Sbjct: 1473 DESQRKR----QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQA--EVE 1526
Query: 181 EERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLK 240
R + + + EL+ + +EK E L V L E E+ Q
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 241 EVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRL 300
E + +E++E ELE + QL+ + L Q + + LA A A + + AE R
Sbjct: 1587 EAERAREEAERELE--RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 301 EVAEVNG-RLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE------------ 347
AE R EL E++ Q ++ G Q A + ++++L AE
Sbjct: 1645 GKAEEQAVRQRELAEQELEKQRQLAE---GTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Query: 348 --ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
+ RL++ + Q + ELA+ + V L+ R E RS +K K++L+
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS---TSEKSKQRLE 1758
Query: 406 EEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 441
E E + + ARL +A+E + E++ A
Sbjct: 1759 AEAGRFRE-LAEEAARLRALAEEAKRQRQLAEEDAA 1793
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 47/333 (14%)
Query: 120 LDESQQERNDLMQLKLQLEGQVTELRSRVQE----LERALATARQEHTELMEQYKGISRS 175
L++ +Q Q K Q E + EL+ R+QE E A A+Q+ + E+ + + +S
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396
Query: 176 HGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKL 235
E +I ++ + A L + +E+ + RL+ ++A R++
Sbjct: 1397 -----SEAEIQAKARQAEAAERSRLR----------IEEEIRVVRLQ--LEATERQRGGA 1439
Query: 236 LGQLKEVQADKEQSEAELEPLKEQLRGAQELAASSQQKATLLGEELAS-------AAAAR 288
G+L+ ++A E++EA+ +E+ + Q+ ELAS AA +
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 289 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAE-KDKILKLSAE 347
R + L RL+ E RL + + + + Q + E A +S EAE + K + +
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETA--QRSAEAELQSKRASFAEK 1556
Query: 348 ILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 407
+LE+++QEE V +L E + Q +E++R E ++E E+ Q +
Sbjct: 1557 TAQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREE-------AERELERWQLK 1605
Query: 408 KQELLEYMRKLEARLEKVADEKWNEDATTEDEE 440
E L +L + E+VA +K A E ++
Sbjct: 1606 ANEAL----RLRLQAEEVAQQKSLAQAEAEKQK 1634
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/304 (22%), Positives = 126/304 (41%), Gaps = 27/304 (8%)
Query: 120 LDESQQERN---DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 176
+D QQ+R+ +L QL+ E ++ + + ER+ +E + Q + R
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436
Query: 177 GEI----------TEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 226
G EE + RQ + R L +Q S++ EVEL
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAER---LRRQVQDESQRKRQAEVELASRVKAEA 1493
Query: 227 ALTREQEKLLGQLKEVQADKEQSEAELEPLK-EQLRGAQELAASSQQKATLLGEELASAA 285
RE+++ L L+E++ E++E L + E+ R Q ++Q+ A EL S
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE---AELQSKR 1550
Query: 286 AARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLS 345
A+ A+L RS E +L E E + Q E + E E ++ +
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEA----ERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 346 AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQ 405
E LRL +E Q + + E ++K+ + E++R A+R + +++L+
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELE 1663
Query: 406 EEKQ 409
+++Q
Sbjct: 1664 KQRQ 1667
Score = 56.6 bits (135), Expect = 6e-08
Identities = 81/361 (22%), Positives = 152/361 (42%), Gaps = 21/361 (5%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+L ++ ++ R+ + K +LE + R +E R A A + + + +R
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1794
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E ER + + A L+ E +I + KE E +RLR + ++ +
Sbjct: 1795 QRAEA--ERVLAEKLAAIGEATRLKTEAEIA-----LKEKEAENERLRRLAEDEAFQRRR 1847
Query: 235 LLGQLKEVQADKEQSEAELEPLKE-QLRGAQELAASSQQKATLLGEELASAAAARDRTIA 293
L Q + +AD E+ A+L + +L + L + ++ + EE+ + A+ ++ A
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907
Query: 294 ELHRSRLEVAEVNGRLAELGLHLKEE-------KCQWSKERAGLLQSVEAEKDKILKLSA 346
LE+ + AE L KE+ + Q + E + E K L
Sbjct: 1908 GKAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966
Query: 347 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ--- 403
E R KA EE + K E AR Q S + +L + + R+ +EK
Sbjct: 1967 EAARQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 404 LQEEKQELLEYMRKLEARLEKVADE-KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDM 462
+Q+++QEL + +++ ++ L+++ E + A E EEA V AA + + E E +
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 463 R 463
+
Sbjct: 2086 K 2086
Score = 53.9 bits (128), Expect = 4e-07
Identities = 80/345 (23%), Positives = 150/345 (43%), Gaps = 37/345 (10%)
Query: 123 SQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEE 182
++Q N + +LQL +L ++ + E ++++Y + + E+T
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE--SVIQEYVDLRTHYSELTT- 1296
Query: 183 RDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEV 242
L+ Q ++ L ++ + ++E+ +E E RL + V+A +Q +L +
Sbjct: 1297 ---LTSQYIKFISETLRRMEEEERLAEQQRAEERE--RLAE-VEAALEKQRQLAEAHAQA 1350
Query: 243 QADKEQSEAELEP-LKEQLRGAQELAASSQQKATLLGEEL-------ASAAAARDRTIAE 294
+A E+ EL+ ++E++ +E A +QQ+ + EEL + A+ R
Sbjct: 1351 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 295 LHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL--QSVEAEKDKILKLSAEILRLE 352
RSRL + E R+ L L E + ++ L ++ EAE K + E RL
Sbjct: 1411 AERSRLRIEE-EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK-RQAQEEAERLR 1468
Query: 353 KAVQEERTQNQVFKTEL----------AREKDSSLVQLSESKRELTELRSALRVLQKEKE 402
+ VQ+E + + + EL AREK +L L E + + E LR Q E E
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR--QAEVE 1526
Query: 403 QLQEEKQELLEYMRKLEARLE----KVADEKWNEDATTEDEEAAV 443
+ ++ + L R EA L+ A++ + + ++E AV
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Score = 48.9 bits (115), Expect = 1e-05
Identities = 85/401 (21%), Positives = 156/401 (38%), Gaps = 96/401 (23%)
Query: 117 QNQLDESQQER--NDLMQLKLQLEGQVTELRSRVQ-----ELERALATARQEHTELMEQY 169
Q +ES+ +R ++L ++LQLE T R++ E R A E + +
Sbjct: 942 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV 1001
Query: 170 KGISRSHGEITEERD-ILSRQQGDHVARILELE-------------------DDIQTIS- 208
+G+ + ++ E + +L+ + A L E + ++TIS
Sbjct: 1002 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1061
Query: 209 --------EKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKEQL 260
E+VL E + V A E E LK+++A E + + L+++L
Sbjct: 1062 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1121
Query: 261 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGR---LAELGLHL- 316
RGAQE+ QQ+ GE R+R L R + +A+ + R L +LG L
Sbjct: 1122 RGAQEVGERLQQRH---GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178
Query: 317 ------------------KEEKCQ------------WSKERAGLLQSVEAEKDKILKLSA 346
++E+ Q ++ LL+ +E +K+ +
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR 1238
Query: 347 EILRLEKAVQEERTQNQVFKTEL-----------AREKDSSLVQ----LSESKRELTELR 391
+ A+++ Q +K +L + S++Q L ELT L
Sbjct: 1239 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1298
Query: 392 S--------ALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 424
S LR +++E+ ++++ E E + ++EA LEK
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339
Score = 35.4 bits (80), Expect = 0.15
Identities = 51/219 (23%), Positives = 91/219 (41%), Gaps = 49/219 (22%)
Query: 115 VLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR 174
+ Q+++ ++QQ R + + + Q+E QE +R +A+ + E +G+ R
Sbjct: 2487 LFQDEVAKAQQLREEQQRQQQQME----------QERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 175 SHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
E+ ++ + RQQ E++L +E + RLR+ ++ L +
Sbjct: 2537 KQEEL-QQLEQQRRQQ------------------EELLAEENQ--RLREQLQLLEEQHRA 2575
Query: 235 LLGQLKEVQA----------------DKEQSEAELEPLKEQLRGAQELAASSQQKATLLG 278
L +EV A D +EAE E + LR ++++A Q+A +L
Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR--RKVSAQRLQEAGILS 2633
Query: 279 EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 317
E A T+ EL R + GR + GL LK
Sbjct: 2634 AEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2672
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,872,425
Number of Sequences: 37866
Number of extensions: 1234865
Number of successful extensions: 17673
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 459
Number of HSP's successfully gapped in prelim test: 1157
Number of HSP's that attempted gapping in prelim test: 7317
Number of HSP's gapped (non-prelim): 5703
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.