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Search of human proteins with 218563726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
(755 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 1525 0.0
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 791 0.0
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 635 0.0
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 626 e-179
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 483 e-136
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 148 2e-35
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 143 7e-34
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 143 7e-34
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 143 7e-34
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 139 7e-33
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 132 2e-30
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 88 3e-17
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 83 8e-16
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 83 8e-16
gi|29788755 SET binding factor 2 [Homo sapiens] 82 1e-15
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 76 1e-13
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 75 2e-13
gi|239735519 SET binding factor 1 [Homo sapiens] 75 3e-13
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 74 4e-13
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 72 2e-12
gi|209863002 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862998 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862994 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|18860873 MAP-kinase activating death domain-containing protei... 52 2e-06
gi|209862987 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862983 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862979 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862975 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209862971 MAP-kinase activating death domain-containing prote... 52 2e-06
gi|209571517 MAP-kinase activating death domain-containing prote... 52 2e-06
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 1525 bits (3949), Expect = 0.0
Identities = 755/755 (100%), Positives = 755/755 (100%)
Query: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
Sbjct: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
Query: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
Sbjct: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN 180
ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVN 180
Query: 181 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP 240
NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP
Sbjct: 181 NMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP 240
Query: 241 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST 300
MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST
Sbjct: 241 MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQST 300
Query: 301 ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL 360
ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL
Sbjct: 301 ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQL 360
Query: 361 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKA 420
FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKA
Sbjct: 361 FKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKGGALFNTAMTKA 420
Query: 421 TPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEK 480
TPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEK
Sbjct: 421 TPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEK 480
Query: 481 RKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTP 540
RKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTP
Sbjct: 481 RKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTP 540
Query: 541 YSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLC 600
YSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLC
Sbjct: 541 YSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLC 600
Query: 601 GGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSLFILKEENSNKHLGADNVSDP 660
GGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSLFILKEENSNKHLGADNVSDP
Sbjct: 601 GGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSLFILKEENSNKHLGADNVSDP 660
Query: 661 TSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLGRHSSTFVPWEKEGKEAKETS 720
TSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLGRHSSTFVPWEKEGKEAKETS
Sbjct: 661 TSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLGRHSSTFVPWEKEGKEAKETS 720
Query: 721 EDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT 755
EDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT
Sbjct: 721 EDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT 755
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 791 bits (2043), Expect = 0.0
Identities = 394/417 (94%), Positives = 395/417 (94%), Gaps = 20/417 (4%)
Query: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
Sbjct: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
Query: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
Sbjct: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 121 ELENDLNETLRSLYNHPVPKANTPVNLSV--------------------HSYFIAPDVTG 160
ELENDLNETLRSLYNHPVPKANTPVNLSV HSYFIAPDVTG
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTG 180
Query: 161 LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY 220
LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY
Sbjct: 181 LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY 240
Query: 221 WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDL 280
WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDL
Sbjct: 241 WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDL 300
Query: 281 NNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESF 340
NNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESF
Sbjct: 301 NNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESF 360
Query: 341 VKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 397
VKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGG +
Sbjct: 361 VKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGKDK 417
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 635 bits (1637), Expect = 0.0
Identities = 355/699 (50%), Positives = 461/699 (65%), Gaps = 40/699 (5%)
Query: 1 MDCRTKANPDRTFDLVLKVKCHASEN--EDPVVLWKFPEDFGDQEILQSVPKFCFPFDVE 58
M R K NP+ TF++ ++V + DP V +FPED+ DQE+LQ++ KFCFPF V+
Sbjct: 1 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 60
Query: 59 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL 118
++ +QVGQ+FTFVLTDI+SKQRFGFCRL+SG C CILSYLPWFEV+YKLLN LADY
Sbjct: 61 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 120
Query: 119 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD 178
K EN NE L +L+ P+P V+LSVHSYF PD LP+IPE+RNLTEYFVAVD
Sbjct: 121 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD 180
Query: 179 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC 238
VNNML LYASML+ERRI+II SKLSTLTACIHGSAA+LYPMYWQH+YIPVLPPHLLDYCC
Sbjct: 181 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC 240
Query: 239 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ 298
APMPYLIGIH SL+E+V+N +L+DVV+LNVDTNTLE+PF DL +LP+DV+S+LKN+LKK
Sbjct: 241 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV 300
Query: 299 STATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN 357
ST TGDGVARAFL+AQAA FGSYR+AL+ +P EPITFCEE+FV H RS M+QFL+ A
Sbjct: 301 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ 360
Query: 358 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKG-GALFNTA 416
LQLFKQFIDGRL LN+G GFSDVFEEEI G + G + + Y QW+ TV+KG GA+ NT
Sbjct: 361 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSD-KLYHQWLSTVRKGSGAILNTV 419
Query: 417 MTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSSSVQY-----TPVYKLH 471
TKA PA++T YKFAK+HAK+G+KEVK++LK K+ E+ + Q +P+ +
Sbjct: 420 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAENGCAPTPEEQLPKTAPSPLVEAK 479
Query: 472 NEKGGNSEKR---KLAQAR------LKRPLKSL--DG---ALYDDEDDDDIERASKLSSE 517
+ K + Q R +KRP ++ +G ++ E + S
Sbjct: 480 DPKLREDRRPITVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQPQPYRTLRESDSA 539
Query: 518 DGEEASAYLYESDDSVETRVKTP-YSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRS 576
+G+EA + + S P + +DLL ++ L ++ Q L AKSL+ R+
Sbjct: 540 EGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLDMEAALQ-PLGQAKSLEDLRA 598
Query: 577 MDDI-------DYKPTNKSNAPSENNLAFLCGGSGDQAE-WNLGQDDSALHGKHLPPSPR 628
D+ DY+ + + + + + W+LGQDD A+ K PP+
Sbjct: 599 PKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSK--PPAAS 656
Query: 629 KRVSSSGLTDSLFILKEENSNKHL----GADNVSDPTSG 663
S+ L +SL + + + + + V PT G
Sbjct: 657 PEKPSALLGNSLALPRRPQNRDSILNPSDKEEVPTPTLG 695
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 626 bits (1614), Expect = e-179
Identities = 307/458 (67%), Positives = 371/458 (81%), Gaps = 5/458 (1%)
Query: 1 MDCRTKANPDRTFDLVLKVKCHASEN--EDPVVLWKFPEDFGDQEILQSVPKFCFPFDVE 58
M R K NP+ TF++ ++V + DP V +FPED+ DQE+LQ++ KFCFPF V+
Sbjct: 1 MGSRIKQNPETTFEVYVEVAYPRTGGTLSDPEVQRQFPEDYSDQEVLQTLTKFCFPFYVD 60
Query: 59 RVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYL 118
++ +QVGQ+FTFVLTDI+SKQRFGFCRL+SG C CILSYLPWFEV+YKLLN LADY
Sbjct: 61 SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILSYLPWFEVFYKLLNILADYT 120
Query: 119 AKELENDLNETLRSLYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESRNLTEYFVAVD 178
K EN NE L +L+ P+P V+LSVHSYF PD LP+IPE+RNLTEYFVAVD
Sbjct: 121 TKRQENQWNELLETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENRNLTEYFVAVD 180
Query: 179 VNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCC 238
VNNML LYASML+ERRI+II SKLSTLTACIHGSAA+LYPMYWQH+YIPVLPPHLLDYCC
Sbjct: 181 VNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCC 240
Query: 239 APMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQ 298
APMPYLIGIH SL+E+V+N +L+DVV+LNVDTNTLE+PF DL +LP+DV+S+LKN+LKK
Sbjct: 241 APMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQSLPNDVISSLKNRLKKV 300
Query: 299 STATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN 357
ST TGDGVARAFL+AQAA FGSYR+AL+ +P EPITFCEE+FV H RS M+QFL+ A
Sbjct: 301 STTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQ 360
Query: 358 LQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQQWVHTVKKG-GALFNTA 416
LQLFKQFIDGRL LN+G GFSDVFEEEI G + G + + Y QW+ TV+KG GA+ NT
Sbjct: 361 LQLFKQFIDGRLDLLNSGEGFSDVFEEEINMGEYAGSD-KLYHQWLSTVRKGSGAILNTV 419
Query: 417 MTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEED 454
TKA PA++T YKFAK+HAK+G+KEVK++LK K+ E+
Sbjct: 420 KTKANPAMKTVYKFAKDHAKMGIKEVKNRLKQKDIAEN 457
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 483 bits (1243), Expect = e-136
Identities = 278/601 (46%), Positives = 366/601 (60%), Gaps = 46/601 (7%)
Query: 1 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 60
M+ R + FD + C AS EDP +L +FP DF DQE +Q VPKFCFPFDVER
Sbjct: 1 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 60
Query: 61 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 120
+ QHFTF LTD+ +RFGFCRL +G CLCILS+LPWFEV+YKLLNT+ D LA+
Sbjct: 61 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 120
Query: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVHS----------------------YFIAPDV 158
+ + E L++L+ + V L + S F+APD
Sbjct: 121 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 180
Query: 159 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 218
LP+IPE+RNLTE VAV N++ L+A++L ERR+++ +SKLSTLT+C+H S ALLYP
Sbjct: 181 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 240
Query: 219 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 278
M W+H+ IP LPPHLLDYCCAPMPYLIG+H+SL ERV+ K+LEDVV+LNVD NTLE+ F+
Sbjct: 241 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 300
Query: 279 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 338
D+ LP DVVS L+ +L+K + A G+GV+R FL+AQA LFG YRDAL PG+P+TF EE
Sbjct: 301 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 360
Query: 339 SFVKHR-SSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 397
F+ + + ++ F A++LQLFKQFI+ RL KLN G GFSD FE+EIT G G R
Sbjct: 361 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR 420
Query: 398 SYQQWVHTVKK-GGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG 456
SYQ W +KK GGAL ++ K PAV+ Y+ AK+ GLK V+S L +K+ +
Sbjct: 421 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ 476
Query: 457 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL 514
S L + ++ + Q K RPL+ S L + + L
Sbjct: 477 RGGS----LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL 532
Query: 515 SSEDGEEASAYLYESDDSVETRVKTPYSG---EMDLLGEILDTLSTHSSDQGKLAAAKSL 571
S ED E + E+ DS + G E+DLL EILD+LS + G L ++SL
Sbjct: 533 SPED--EGCPWAEEALDS-------SFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSL 583
Query: 572 D 572
D
Sbjct: 584 D 584
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 148 bits (373), Expect = 2e-35
Identities = 119/401 (29%), Positives = 199/401 (49%), Gaps = 43/401 (10%)
Query: 33 WKFPEDFGDQEILQSVPKFCFPFDVERVSQNQ-VGQHFTFVLTDIESKQRFGFCR-LTSG 90
+KF + DQ L+++P+FCFP + V Q + F+FVLT + +RFG+CR L G
Sbjct: 598 FKFMREAEDQ--LKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPG 655
Query: 91 GT-----ICLCILSYLPWFEVYYKLLNTLADY--LAKELENDLNETLRSLYNHPVPKANT 143
G CI+S L F ++ ++L+ + ++ L L +RS+ P P
Sbjct: 656 GKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPL---MRSVMEAPFPALGK 712
Query: 144 PVNLSVHSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIIS 199
+ + +V L +SR + F ++ V +++ ++AS+L ERR++ I+
Sbjct: 713 TILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIA 772
Query: 200 SKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKS 259
KLS L+ C H AL+YP WQH YIPVLPP ++D C+P P+LIG+ SS + ++
Sbjct: 773 DKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELP 832
Query: 260 LEDVVMLN-VDTNTLESPFSDLNNLPSDVVSALKNKLKK-------------------QS 299
LE+V++++ V++ L + + LP + AL++ L++ +S
Sbjct: 833 LEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPES 892
Query: 300 TATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSS-VMKQFLETAINL 358
+ + V+ AF+R + G Y L E T E+F K SS ++ FLE +
Sbjct: 893 SPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMET 952
Query: 359 QLFKQFIDGRLAKLNAGRGFSDV----FEEEITSGGFCGGN 395
Q+F+ FI R + +G +V + E + SG G N
Sbjct: 953 QMFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVN 993
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 143 bits (360), Expect = 7e-34
Identities = 105/378 (27%), Positives = 183/378 (48%), Gaps = 42/378 (11%)
Query: 42 QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95
+E L+++P+FCFP + + ++ F+F+LT + +RFG+CR L SG L
Sbjct: 736 EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 795
Query: 96 -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETL-----RSLYNHPVPKANTPVNLSV 149
C++S L F ++ K+L+ + E ++ L RSL P P + +
Sbjct: 796 YCVISRLGCFGLFSKVLDEV------ERRRGISAALVYPFMRSLMESPFPAPGKTIKVKT 849
Query: 150 HSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 205
+V L +SR + F + V +++++AS+L ERR++ ++ KLSTL
Sbjct: 850 FLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTL 909
Query: 206 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 265
++C H ALLYP WQH +IPVLP ++D C P P+L+G+ SS + ++K +E+ +M
Sbjct: 910 SSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALM 969
Query: 266 LNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG---------------VARA 309
+N+ ++ D + LP + +AL+ L++++ V+
Sbjct: 970 VNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEV 1029
Query: 310 FLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGR 368
F+R G Y L F E+F K S +++FLE + Q+F FI R
Sbjct: 1030 FIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDR 1089
Query: 369 LAKLNAGRGFSDVFEEEI 386
+ +G +FE+ +
Sbjct: 1090 ELRKCRAKG---LFEQRV 1104
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 143 bits (360), Expect = 7e-34
Identities = 105/378 (27%), Positives = 183/378 (48%), Gaps = 42/378 (11%)
Query: 42 QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95
+E L+++P+FCFP + + ++ F+F+LT + +RFG+CR L SG L
Sbjct: 736 EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 795
Query: 96 -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETL-----RSLYNHPVPKANTPVNLSV 149
C++S L F ++ K+L+ + E ++ L RSL P P + +
Sbjct: 796 YCVISRLGCFGLFSKVLDEV------ERRRGISAALVYPFMRSLMESPFPAPGKTIKVKT 849
Query: 150 HSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 205
+V L +SR + F + V +++++AS+L ERR++ ++ KLSTL
Sbjct: 850 FLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTL 909
Query: 206 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 265
++C H ALLYP WQH +IPVLP ++D C P P+L+G+ SS + ++K +E+ +M
Sbjct: 910 SSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALM 969
Query: 266 LNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG---------------VARA 309
+N+ ++ D + LP + +AL+ L++++ V+
Sbjct: 970 VNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEV 1029
Query: 310 FLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGR 368
F+R G Y L F E+F K S +++FLE + Q+F FI R
Sbjct: 1030 FIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDR 1089
Query: 369 LAKLNAGRGFSDVFEEEI 386
+ +G +FE+ +
Sbjct: 1090 ELRKCRAKG---LFEQRV 1104
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 143 bits (360), Expect = 7e-34
Identities = 105/378 (27%), Positives = 183/378 (48%), Gaps = 42/378 (11%)
Query: 42 QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95
+E L+++P+FCFP + + ++ F+F+LT + +RFG+CR L SG L
Sbjct: 316 EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 375
Query: 96 -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETL-----RSLYNHPVPKANTPVNLSV 149
C++S L F ++ K+L+ + E ++ L RSL P P + +
Sbjct: 376 YCVISRLGCFGLFSKVLDEV------ERRRGISAALVYPFMRSLMESPFPAPGKTIKVKT 429
Query: 150 HSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 205
+V L +SR + F + V +++++AS+L ERR++ ++ KLSTL
Sbjct: 430 FLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTL 489
Query: 206 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 265
++C H ALLYP WQH +IPVLP ++D C P P+L+G+ SS + ++K +E+ +M
Sbjct: 490 SSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALM 549
Query: 266 LNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG---------------VARA 309
+N+ ++ D + LP + +AL+ L++++ V+
Sbjct: 550 VNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEV 609
Query: 310 FLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGR 368
F+R G Y L F E+F K S +++FLE + Q+F FI R
Sbjct: 610 FIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDR 669
Query: 369 LAKLNAGRGFSDVFEEEI 386
+ +G +FE+ +
Sbjct: 670 ELRKCRAKG---LFEQRV 684
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 139 bits (351), Expect = 7e-33
Identities = 112/408 (27%), Positives = 205/408 (50%), Gaps = 48/408 (11%)
Query: 15 LVLKVKCHASENE-DPVVLWKFPEDF----GDQE----ILQSVPKFCFPFDVERVSQNQV 65
LV+ +K SE++ +P++ ++FP+ G QE +L+++P FCFP E S +
Sbjct: 58 LVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEY 117
Query: 66 GQH-FTFVLTDIESKQRFGFCR--LTSGGTICL----CILSYLPWFEVYYKLLNTLADYL 118
+ F+FVLT+++ ++ G+CR L +G L CI+S + F ++ K+L+ +
Sbjct: 118 PRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEV---- 173
Query: 119 AKELENDLNETLRSLYNHPVPKANTPV---NLSVHSYFIAPDVTGLPTIPESRNLTEYFV 175
E + ++ + + + +A P +++ S+ PD +G I +R L +
Sbjct: 174 --EKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFI--PD-SGTEFISLTRPLDSHLE 228
Query: 176 AVDVNNML---------QLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYI 226
VD +++L Q++AS + ER+I+ ++ LSTL+ CIH +AALLYP W H YI
Sbjct: 229 HVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYI 288
Query: 227 PVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN---- 282
PV+P LL C P P+++G+ + V + +E+V+++N+ T D +
Sbjct: 289 PVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPP 348
Query: 283 -LPSDVVSALKNKLKKQSTA--TGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEES 339
L D++ +L + + TA + V+ F++ + G Y ++ + F E S
Sbjct: 349 KLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERS 408
Query: 340 FVKH-RSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEI 386
F K S ++F++ + QLF FI N G+ F+++I
Sbjct: 409 FCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGY---FQQKI 453
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 132 bits (331), Expect = 2e-30
Identities = 105/387 (27%), Positives = 189/387 (48%), Gaps = 36/387 (9%)
Query: 29 PVVLWKFP--EDFGD------QEILQSVPKFCFPFDVERVSQNQV-GQHFTFVLTDIESK 79
P V+ +FP +D G +E L+ +PKFCFP + + +++ + F+FVLT +
Sbjct: 453 PQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGS 512
Query: 80 QRFGFCR----LTSGGTI--CLCILSYLPWFEVYYKLLNTLADYLAKELENDL-NETLRS 132
+ FG+C+ + G + C++S L F ++ K+L+ + +E+ L +RS
Sbjct: 513 RWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEK--RREMSPALVYPFMRS 570
Query: 133 LYNHPVPKANTPVNLSVHSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYAS 188
+ P P + + + + L +SR + F + V +++++ AS
Sbjct: 571 VMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCAS 630
Query: 189 MLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIH 248
+L ERR++ +++ LSTL+ C H A LYP WQH YIPVLP ++D C+P P+LIGI
Sbjct: 631 LLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGIL 690
Query: 249 SSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN-LPSDVVSALKNKLKK---------- 297
S + ++++ +E+V+++++ + SD + LP + +AL L++
Sbjct: 691 SCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQN 750
Query: 298 --QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVK-HRSSVMKQFLET 354
Q V+ AF+R L G Y + F E F K H S ++ FL+
Sbjct: 751 FSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFLDL 810
Query: 355 AINLQLFKQFIDGRLAKLNAGRGFSDV 381
+ Q+F FI R + + +G ++
Sbjct: 811 FMETQMFAGFIQDRELRKSGVKGLFEI 837
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 87.8 bits (216), Expect = 3e-17
Identities = 90/368 (24%), Positives = 146/368 (39%), Gaps = 62/368 (16%)
Query: 50 KFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYK 109
+F P+ E +S+ Q+ H +LT +E K + C+C+LS+ P+FE + K
Sbjct: 38 QFYEPYSRELLSEKQL-MHLG-LLTPVERKM----VSKSINTNKCICLLSHWPFFEAFRK 91
Query: 110 LLNTLADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGL 161
L + +E ++ ++++ P P P V LSVH I
Sbjct: 92 FLMFIYKLSVSGPHPLPIEKHISHFMQNI---PFPSPQRPRILVQLSVHDALILSQPVST 148
Query: 162 PTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYW 221
P N + + + N L +L E +I++ S + + LT A+++P W
Sbjct: 149 PLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQW 208
Query: 222 QHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTL----ESPF 277
Q YIP+ P L AP+P+++G+ S + + +DVV +++DTN L E
Sbjct: 209 QCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD--LHDPPQDVVCIDLDTNMLYVSDEKKN 266
Query: 278 SDLNNLPSDVVSALKNKLKK---------QSTATGDG----------------------V 306
+ LP L + LKK Q T G +
Sbjct: 267 MNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEI 326
Query: 307 ARAFLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINL 358
AFLR A++ YR LR P T F + F+K R +F
Sbjct: 327 QEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKT 386
Query: 359 QLFKQFID 366
Q+F +FI+
Sbjct: 387 QIFIRFIE 394
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 83.2 bits (204), Expect = 8e-16
Identities = 100/425 (23%), Positives = 158/425 (37%), Gaps = 95/425 (22%)
Query: 31 VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84
++ ++P ED+ + +SVP FC P S+ + TFVLT +++ +G
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
Query: 85 C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113
RL G T C+C+LS+ P+F+ + K L
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
Query: 114 LADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGLPTIP 165
L Y +E ++ + + P P P V LS H I P
Sbjct: 332 LYRYSISGPHVLPIEKHISHFMHKV---PFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
Query: 166 ESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIY 225
+ + N + L + E +I+I S + S LT+ ++++P +W Y
Sbjct: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
Query: 226 IPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN--- 282
+P+ P L D AP P+++GI S + DV ++VDTNT+ S D N
Sbjct: 449 VPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI-SQIGDKKNVAW 505
Query: 283 --LPSDVVSALKNKL--------KKQSTATGDG-----------------------VARA 309
LP L N L K Q DG + A
Sbjct: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
Query: 310 FLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINLQLF 361
FL A++ YR LR P E T F ++F++ R ++F Q+F
Sbjct: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMF 625
Query: 362 KQFID 366
+FI+
Sbjct: 626 IRFIE 630
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 83.2 bits (204), Expect = 8e-16
Identities = 100/425 (23%), Positives = 158/425 (37%), Gaps = 95/425 (22%)
Query: 31 VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84
++ ++P ED+ + +SVP FC P S+ + TFVLT +++ +G
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
Query: 85 C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113
RL G T C+C+LS+ P+F+ + K L
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
Query: 114 LADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGLPTIP 165
L Y +E ++ + + P P P V LS H I P
Sbjct: 332 LYRYSISGPHVLPIEKHISHFMHKV---PFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
Query: 166 ESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIY 225
+ + N + L + E +I+I S + S LT+ ++++P +W Y
Sbjct: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
Query: 226 IPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN--- 282
+P+ P L D AP P+++GI S + DV ++VDTNT+ S D N
Sbjct: 449 VPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI-SQIGDKKNVAW 505
Query: 283 --LPSDVVSALKNKL--------KKQSTATGDG-----------------------VARA 309
LP L N L K Q DG + A
Sbjct: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
Query: 310 FLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINLQLF 361
FL A++ YR LR P E T F ++F++ R ++F Q+F
Sbjct: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMF 625
Query: 362 KQFID 366
+FI+
Sbjct: 626 IRFIE 630
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 82.4 bits (202), Expect = 1e-15
Identities = 90/398 (22%), Positives = 154/398 (38%), Gaps = 64/398 (16%)
Query: 31 VLWKFPE-DFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFC---- 85
++ +FP+ D+ D Q + FC P + + + F VLTDI+S + + C
Sbjct: 27 IIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFY 86
Query: 86 --RLTSGGTI-----------------------CLCILSYLPWFEVYYKLLNTLADYLAK 120
+ GT L ++S L + E++ L +
Sbjct: 87 EAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVD 146
Query: 121 ELENDLNETLRSLYNHPVPKANTPVNL-----SVHSYFIAPDVTGLPTIPESRNLTEYFV 175
L L + +L VP A L P LP S L F
Sbjct: 147 SLNVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALL--FQ 204
Query: 176 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD 235
+ + N+L L+ ++L E +++ S+ L+ +L++P+ + + YIP+LP LL+
Sbjct: 205 QLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLE 264
Query: 236 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESP-FSDLNNLPSDVVSALKNK 294
+P P++IG+HS + + L DV++ ++D T++ P L++LP ++ ++
Sbjct: 265 VLSSPTPFIIGVHS--VFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSA 322
Query: 295 LK---------------------KQSTATGDGVARAFLRAQAALFGSYRDAL---RYKPG 330
L S V FLR A LF YR L R
Sbjct: 323 LSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAE 382
Query: 331 EPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGR 368
I F + +F+ R V FL ++ F F+ R
Sbjct: 383 PVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 76.3 bits (186), Expect = 1e-13
Identities = 58/224 (25%), Positives = 103/224 (45%), Gaps = 15/224 (6%)
Query: 74 TDIESKQRFG---FCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDL---N 127
T + QRF R T + C+C+++ + + + +L L + L +
Sbjct: 183 TPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLES 242
Query: 128 ETLRSLYNHPVPKANTPVNLS-VHSYFIA--PDVTGLPTIPESRNLTEYFVAVDVNNMLQ 184
LY P+P + S V+ I P LP + E F + V N+ Q
Sbjct: 243 YIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFP--VKEVFELLGVENVFQ 300
Query: 185 LYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYL 244
L+ L E +I++ S L AL++P WQH+Y+P+LP LL + AP+PYL
Sbjct: 301 LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL 360
Query: 245 IGIHSSLIE---RVKNKSLEDVVMLNVDTNTLESPFSDLNNLPS 285
+G+HS+ ++ +++ ++ +++D + +E P DL P+
Sbjct: 361 MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELP-EDLPQFPN 403
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 75.1 bits (183), Expect = 2e-13
Identities = 53/198 (26%), Positives = 94/198 (47%), Gaps = 25/198 (12%)
Query: 95 LCILSYLPWFEVYYKLLNTLADYLAKE------LENDLNETLRSLYNHPVPKANTPVNLS 148
+C+++ LP+ + K L L + + LE+ ++ L Y P+P P S
Sbjct: 192 ICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNIL---YEVPLP----PPGRS 244
Query: 149 VHSYFIAPDVTGLPTIPESRNLTEY-----FVAVDVNNMLQLYASMLHERRIVIISSKLS 203
+ Y + V P L++Y F + + N++Q++ +L E +I++ S
Sbjct: 245 LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQ 304
Query: 204 TLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLE-- 261
L G LL+P WQH+Y+P+LP LL + AP+PYL+G+ S E LE
Sbjct: 305 RLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSK--EGTDRSKLELP 362
Query: 262 ---DVVMLNVDTNTLESP 276
++ +++D + +E P
Sbjct: 363 QEANLCFVDIDNHFIELP 380
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 74.7 bits (182), Expect = 3e-13
Identities = 93/409 (22%), Positives = 156/409 (38%), Gaps = 74/409 (18%)
Query: 31 VLWKFPE-DFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRL-- 87
+L +FPE D+ D Q + FC P + + F VLTDI S++ + C
Sbjct: 27 ILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPERNPPTFFVAVLTDINSERHYCACLTFW 86
Query: 88 ----------------------TSGGTI-----------------CLCILSYLPWFEVYY 108
GG L ++S L EV+
Sbjct: 87 EPAEPSQETTRVEDATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSRLDHTEVFR 146
Query: 109 KLLNTLADYLAKELENDLNETLRSLYNHPVPKAN---TPVNLSVHSYFIAPDVTGLPTIP 165
L + + L L + +L VP A ++L + ++P
Sbjct: 147 NSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAGGSQRTISLGAGDRQVIQTPLA-DSLP 205
Query: 166 ESR-NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHI 224
SR ++ F + + N+L L+ + L E +++ +S L G ALL+P+ +
Sbjct: 206 VSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFT 265
Query: 225 YIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESP-FSDLNNL 283
Y+P+LP LL+ P P++IG++++ + + + L DV++ ++D T+ P + L
Sbjct: 266 YVPILPAQLLEVLSTPTPFIIGVNAAF--QAETQELLDVIVADLDGGTVTIPECVHIPPL 323
Query: 284 PSDVVSALKNKLK---------------KQSTATG-----DGVARA-FLRAQAALFGSYR 322
P + S + L +T+T D RA FLR A L YR
Sbjct: 324 PEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSLKMQDKELRAVFLRLFAQLLQGYR 383
Query: 323 ---DALRYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGR 368
+R P I F + +F+ R V FL + F F+ R
Sbjct: 384 WCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSER 432
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 74.3 bits (181), Expect = 4e-13
Identities = 87/386 (22%), Positives = 157/386 (40%), Gaps = 67/386 (17%)
Query: 45 LQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFG------------FCRLTSGGT 92
L ++P+ CFP V ++ + VLTD+ + +G +C +G T
Sbjct: 39 LLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYC-FYNGKT 97
Query: 93 ----------ICLCILSYLPWFEVYYKLLNTLADYLAK----ELENDLNETLRSLYNHPV 138
+C++S P++ L+ L L E+++ + + L P
Sbjct: 98 HRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPS 157
Query: 139 PKANTPVNL--SVHSYFIAPDVTGLPTIPE-SRNLTEYFVAVDVNNMLQLYASMLHERRI 195
P P++L ++ S I P P +L + +LQ+ +L E+RI
Sbjct: 158 PPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRI 216
Query: 196 VIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERV 255
V SS + LT A LYP+ WQH ++P+L +LD+ AP +L+G H E V
Sbjct: 217 VFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEV 276
Query: 256 KNKSLEDVVMLNVD--TNTLESPFSDLNNLPSDVVSALKNKLKK---------------- 297
+K + +V++N+D + T D ++P + A + +++
Sbjct: 277 -SKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLL 335
Query: 298 QSTATGDG--------------VARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH 343
ST +G + + L+ ++F ++ L Y E F E F+K
Sbjct: 336 SSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNY---EHRVFNSEEFLKT 392
Query: 344 RSSVMKQFLETAINLQLFKQFIDGRL 369
R+ QF + ++ +F F+ RL
Sbjct: 393 RAPGDHQFYKQVLDTYMFHSFLKARL 418
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 72.0 bits (175), Expect = 2e-12
Identities = 77/323 (23%), Positives = 126/323 (39%), Gaps = 57/323 (17%)
Query: 95 LCILSYLPWFEVYYKLLNTLADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VN 146
+ +LS P F + L L Y LE ++ + +N P P P V
Sbjct: 318 IAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFI---HNVPFPSPQRPRILVQ 374
Query: 147 LSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLT 206
+S + + P + + ++ + L ++L E ++++ S + LT
Sbjct: 375 MSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLT 434
Query: 207 ACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVML 266
+ ++++P++WQ YIP+ P L D AP+P+++GIHSS + + DV+ +
Sbjct: 435 SVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICV 492
Query: 267 NVDTNT--------LESPFSDLNNLPSDVVSALKNKLKKQSTATGDG------------- 305
++DTNT L SP L P V+ A L +Q T G
Sbjct: 493 DLDTNTLFQTEEKKLLSP-RTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTD 551
Query: 306 --------------VARAFLRAQAALFGSYRDALRYKPGEPI--------TFCEESFVKH 343
V AFLR A L YR LR P F + F+K
Sbjct: 552 YEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS 611
Query: 344 RSSVMKQFLETAINLQLFKQFID 366
R + ++ Q+F QFI+
Sbjct: 612 RERSSHKLYSQLLHTQMFSQFIE 634
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 52.4 bits (124), Expect = 2e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
LC+LS+ P+F + + L TL L +E
Sbjct: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
Query: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
Query: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
Query: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
Query: 284 PSDVVSALKNKLKK 297
P LK LK+
Sbjct: 417 PEPESLELKKHLKQ 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,730,371
Number of Sequences: 37866
Number of extensions: 1298680
Number of successful extensions: 4435
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 4287
Number of HSP's gapped (non-prelim): 133
length of query: 755
length of database: 18,247,518
effective HSP length: 110
effective length of query: 645
effective length of database: 14,082,258
effective search space: 9083056410
effective search space used: 9083056410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.