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Search of human proteins with 218505831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505831 TRAF4 associated factor 1 isoform b [Homo sapiens]
(286 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505831 TRAF4 associated factor 1 isoform b [Homo sapiens] 567 e-162
gi|218505827 TRAF4 associated factor 1 isoform a [Homo sapiens] 540 e-154
gi|218505833 TRAF4 associated factor 1 isoform c [Homo sapiens] 455 e-128
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 46 4e-05
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap... 46 4e-05
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap... 46 4e-05
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap... 46 4e-05
gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens] 42 5e-04
gi|56790919 haspin [Homo sapiens] 42 5e-04
gi|110349797 homer 2 isoform 4 [Homo sapiens] 42 6e-04
gi|110349794 homer 2 isoform 3 [Homo sapiens] 42 8e-04
gi|4506467 radixin [Homo sapiens] 41 0.001
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 41 0.001
gi|33946313 ninein isoform 4 [Homo sapiens] 40 0.002
gi|33946321 ninein isoform 5 [Homo sapiens] 40 0.002
gi|148536871 ninein isoform 1 [Homo sapiens] 40 0.002
gi|148536869 ninein isoform 2 [Homo sapiens] 40 0.002
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 40 0.003
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 39 0.004
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 39 0.007
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 38 0.009
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 38 0.009
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 38 0.009
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 38 0.009
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 38 0.009
gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo sa... 38 0.009
gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo s... 38 0.009
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 38 0.009
gi|31542661 transmembrane protein 57 [Homo sapiens] 38 0.009
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 38 0.009
>gi|218505831 TRAF4 associated factor 1 isoform b [Homo sapiens]
Length = 286
Score = 567 bits (1462), Expect = e-162
Identities = 286/286 (100%), Positives = 286/286 (100%)
Query: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK
Sbjct: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
Query: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV
Sbjct: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
Query: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ
Sbjct: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
Query: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE 240
LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE
Sbjct: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE 240
Query: 241 STTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNHGILHQM 286
STTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNHGILHQM
Sbjct: 241 STTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNHGILHQM 286
>gi|218505827 TRAF4 associated factor 1 isoform a [Homo sapiens]
Length = 316
Score = 540 bits (1392), Expect = e-154
Identities = 274/274 (100%), Positives = 274/274 (100%)
Query: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK
Sbjct: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
Query: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV
Sbjct: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
Query: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ
Sbjct: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
Query: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE 240
LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE
Sbjct: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQE 240
Query: 241 STTDHMDSMLLLETLQEELKLFNETAKKQMEELQ 274
STTDHMDSMLLLETLQEELKLFNETAKKQMEELQ
Sbjct: 241 STTDHMDSMLLLETLQEELKLFNETAKKQMEELQ 274
>gi|218505833 TRAF4 associated factor 1 isoform c [Homo sapiens]
Length = 241
Score = 455 bits (1170), Expect = e-128
Identities = 228/228 (100%), Positives = 228/228 (100%)
Query: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK
Sbjct: 1 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
Query: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV
Sbjct: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
Query: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ
Sbjct: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
Query: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDP 228
LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDP
Sbjct: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDP 228
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/166 (26%), Positives = 79/166 (47%), Gaps = 24/166 (14%)
Query: 118 KEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKD 177
K+ + KQ++ END KL+ E + +A + A +N + Y E+EL+
Sbjct: 257 KQESLEKQINDLKSENDALN-EKLKSEEQKRRAREKANLKNPQIMYL-------EQELES 308
Query: 178 KNQLLEAVNKQLHQ---KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSET 234
+LE N++LHQ KL + + + + T V+ L++F+ E++ L +
Sbjct: 309 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ------ENEELKARMDKHM 362
Query: 235 LASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNH 280
SRQ ST + +L E+L++E K+ + ME ++ W H
Sbjct: 363 AISRQLST----EQAVLQESLEKESKV---NKRLSMENEELLWKLH 401
>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
Length = 1270
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/166 (26%), Positives = 79/166 (47%), Gaps = 24/166 (14%)
Query: 118 KEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKD 177
K+ + KQ++ END KL+ E + +A + A +N + Y E+EL+
Sbjct: 1091 KQESLEKQINDLKSENDALN-EKLKSEEQKRRAREKANLKNPQIMYL-------EQELES 1142
Query: 178 KNQLLEAVNKQLHQ---KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSET 234
+LE N++LHQ KL + + + + T V+ L++F+ E++ L +
Sbjct: 1143 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ------ENEELKARMDKHM 1196
Query: 235 LASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNH 280
SRQ ST + +L E+L++E K+ + ME ++ W H
Sbjct: 1197 AISRQLST----EQAVLQESLEKESKV---NKRLSMENEELLWKLH 1235
>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
Length = 1216
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/166 (26%), Positives = 79/166 (47%), Gaps = 24/166 (14%)
Query: 118 KEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKD 177
K+ + KQ++ END KL+ E + +A + A +N + Y E+EL+
Sbjct: 1037 KQESLEKQINDLKSENDALN-EKLKSEEQKRRAREKANLKNPQIMYL-------EQELES 1088
Query: 178 KNQLLEAVNKQLHQ---KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSET 234
+LE N++LHQ KL + + + + T V+ L++F+ E++ L +
Sbjct: 1089 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ------ENEELKARMDKHM 1142
Query: 235 LASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNH 280
SRQ ST + +L E+L++E K+ + ME ++ W H
Sbjct: 1143 AISRQLST----EQAVLQESLEKESKV---NKRLSMENEELLWKLH 1181
>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
Length = 517
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/166 (26%), Positives = 79/166 (47%), Gaps = 24/166 (14%)
Query: 118 KEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKD 177
K+ + KQ++ END KL+ E + +A + A +N + Y E+EL+
Sbjct: 338 KQESLEKQINDLKSENDALN-EKLKSEEQKRRAREKANLKNPQIMYL-------EQELES 389
Query: 178 KNQLLEAVNKQLHQ---KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSET 234
+LE N++LHQ KL + + + + T V+ L++F+ E++ L +
Sbjct: 390 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ------ENEELKARMDKHM 443
Query: 235 LASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQIAWMNH 280
SRQ ST + +L E+L++E K+ + ME ++ W H
Sbjct: 444 AISRQLST----EQAVLQESLEKESKV---NKRLSMENEELLWKLH 482
>gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]
Length = 636
Score = 42.4 bits (98), Expect = 5e-04
Identities = 56/213 (26%), Positives = 93/213 (43%), Gaps = 32/213 (15%)
Query: 84 KTVYSLQPPSALSGGQPADTQTRATSKSLLPV---RSKEVDVSKQLHS---GGPENDVTK 137
K V Q S +G P A K + + RS+ ++V+KQ + K
Sbjct: 275 KAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQK 334
Query: 138 ITKLRRENG--QMKATDT-ATRRNVRKGYKP---LSKQKSEEELKDKNQLLEAVNKQLHQ 191
IT+LR++ Q + TD A R ++ + L+K K E E DK QL A K+L Q
Sbjct: 335 ITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLT-AEAKELRQ 393
Query: 192 KLTETQGELKDLT-------QKVELLEKFRDNCLAILESKGLDPAL-----GSETLASRQ 239
K+ Q +L LT ++++ L K + L+I P G+ L +Q
Sbjct: 394 KVKYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQ 453
Query: 240 ESTTDHMDSMLLLETLQEELKLFNETAKKQMEE 272
E T + E L++++K+F E +++ +
Sbjct: 454 ELVTQN-------ELLKQQVKIFEEDFQRERSD 479
>gi|56790919 haspin [Homo sapiens]
Length = 798
Score = 42.4 bits (98), Expect = 5e-04
Identities = 46/188 (24%), Positives = 75/188 (39%), Gaps = 20/188 (10%)
Query: 18 LSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKD-----CGQDRRAPGVQ 72
L++ C P P + +A L + V +G L E D C Q+ G +
Sbjct: 172 LASPCPGSPTPRD--SVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAK 229
Query: 73 PCRLV--TMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGG 130
R+V T S+ ++ L ++ G P D++ RA K++ K K + G
Sbjct: 230 DTRMVHQTRASLRSVLFGL-----MNSGTPEDSEFRADGKNMRESCCKR----KLVVGNG 280
Query: 131 PENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELK--DKNQLLEAVNKQ 188
PE T RR GQ + + VR+ ++ S K + D+ + + K
Sbjct: 281 PEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKS 340
Query: 189 LHQKLTET 196
HQ+ TET
Sbjct: 341 KHQEATET 348
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 42.0 bits (97), Expect = 6e-04
Identities = 48/170 (28%), Positives = 77/170 (45%), Gaps = 19/170 (11%)
Query: 106 RATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKP 165
R T S D K H+G P N T L+ EN ++K T + NV
Sbjct: 133 RETPSSTQASSVNGTDDEKASHAG-PAN-----THLKSENDKLKIALTQSAANV------ 180
Query: 166 LSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKG 225
K + E K+KN L+ ++L +L E + ELKDL ++ E++ + C + S+
Sbjct: 181 --KNEINRE-KEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYV--SEK 235
Query: 226 LDPA-LGSETLASRQES-TTDHMDSMLLLETLQEELKLFNETAKKQMEEL 273
L+ A ++ L + S TD +S L+ ELK F E ++++L
Sbjct: 236 LEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 285
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 41.6 bits (96), Expect = 8e-04
Identities = 45/155 (29%), Positives = 74/155 (47%), Gaps = 19/155 (12%)
Query: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ 180
D K H+G P N T L+ EN ++K T + NV K + E K+KN
Sbjct: 137 DDEKASHAG-PAN-----THLKSENDKLKIALTQSAANV--------KNEINRE-KEKNT 181
Query: 181 LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPA-LGSETLASRQ 239
L+ ++L +L E + ELKDL ++ E++ + C + S+ L+ A ++ L +
Sbjct: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYV--SEKLEAAERDNQNLEDKV 239
Query: 240 ES-TTDHMDSMLLLETLQEELKLFNETAKKQMEEL 273
S TD +S L+ ELK F E ++++L
Sbjct: 240 RSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 274
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 40.8 bits (94), Expect = 0.001
Identities = 39/158 (24%), Positives = 67/158 (42%), Gaps = 11/158 (6%)
Query: 134 DVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKL 193
+V ++ RE K + A N +K + K+K E ++K +L+E + KQ+ ++
Sbjct: 301 EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIE-REKEELMERL-KQIEEQT 358
Query: 194 TETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLE 253
+ Q EL++ T+K L++ R E + E ++ + D M + E
Sbjct: 359 IKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQ---E 415
Query: 254 TLQEELKLFN------ETAKKQMEELQIAWMNHGILHQ 285
L EL F E AKK+ EE W + Q
Sbjct: 416 QLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQ 453
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 40.8 bits (94), Expect = 0.001
Identities = 45/180 (25%), Positives = 77/180 (42%), Gaps = 12/180 (6%)
Query: 97 GGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTK--ITKLRRENGQMKATDTA 154
G + + T TS++L +R + S Q+ E K + K++ + Q K A
Sbjct: 795 GARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEA 854
Query: 155 TRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFR 214
RR+ SK + ELK + L++ K+L Q+L + GE + T + EL R
Sbjct: 855 YRRDAT------SKDQLISELKATRKRLDSELKELRQELMQVHGEKR--TAEAELSRLHR 906
Query: 215 DNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEELQ 274
+ L+ L ++ ++ H+ S+ + + NE KKQ+EELQ
Sbjct: 907 EVAQVRQHMADLEGHL--QSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQ 964
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 66/136 (48%), Gaps = 16/136 (11%)
Query: 132 ENDVTKITKLRRENGQMKA----TDTATRRN--VRKGYKPLSKQKSEEELKDKNQLLEAV 185
E D KL NG + T+T + N V+K + L KQ SE LK KNQ L+
Sbjct: 1541 EEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE--LKIKNQQLDLE 1598
Query: 186 NKQLHQKLTETQGELKDLTQKVE--LLEKFRDNCLAILESKGLDPALGSETLASRQESTT 243
N +L QK ++ Q +L++L Q++ L +K ++ + LE + E ++E
Sbjct: 1599 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER------EQEKFNLKEELER 1652
Query: 244 DHMDSMLLLETLQEEL 259
+ S L+ +L+ EL
Sbjct: 1653 CKVQSSTLVSSLEAEL 1668
Score = 32.3 bits (72), Expect = 0.49
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 22/185 (11%)
Query: 110 KSLLPVRSKEVDVSKQLHSGGPENDVTKITK-LRRENGQMKATDTATRRN-VRKGYKPLS 167
KS L V +E + KQ +V + K L+ G+ A + AT + + K LS
Sbjct: 1792 KSDLRVTQQEKEALKQ--------EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1843
Query: 168 KQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----------FRDNC 217
K + + ++ QLL N++L + T+ EL +KV LE
Sbjct: 1844 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1903
Query: 218 LAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL--QI 275
+ E + L + Q + M LE E + L NE KK+ +L Q+
Sbjct: 1904 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1963
Query: 276 AWMNH 280
M H
Sbjct: 1964 MEMQH 1968
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 66/136 (48%), Gaps = 16/136 (11%)
Query: 132 ENDVTKITKLRRENGQMKA----TDTATRRN--VRKGYKPLSKQKSEEELKDKNQLLEAV 185
E D KL NG + T+T + N V+K + L KQ SE LK KNQ L+
Sbjct: 1535 EEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE--LKIKNQQLDLE 1592
Query: 186 NKQLHQKLTETQGELKDLTQKVE--LLEKFRDNCLAILESKGLDPALGSETLASRQESTT 243
N +L QK ++ Q +L++L Q++ L +K ++ + LE + E ++E
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER------EQEKFNLKEELER 1646
Query: 244 DHMDSMLLLETLQEEL 259
+ S L+ +L+ EL
Sbjct: 1647 CKVQSSTLVSSLEAEL 1662
Score = 32.3 bits (72), Expect = 0.49
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 22/185 (11%)
Query: 110 KSLLPVRSKEVDVSKQLHSGGPENDVTKITK-LRRENGQMKATDTATRRN-VRKGYKPLS 167
KS L V +E + KQ +V + K L+ G+ A + AT + + K LS
Sbjct: 1786 KSDLRVTQQEKEALKQ--------EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 168 KQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----------FRDNC 217
K + + ++ QLL N++L + T+ EL +KV LE
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1897
Query: 218 LAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL--QI 275
+ E + L + Q + M LE E + L NE KK+ +L Q+
Sbjct: 1898 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1957
Query: 276 AWMNH 280
M H
Sbjct: 1958 MEMQH 1962
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 66/136 (48%), Gaps = 16/136 (11%)
Query: 132 ENDVTKITKLRRENGQMKA----TDTATRRN--VRKGYKPLSKQKSEEELKDKNQLLEAV 185
E D KL NG + T+T + N V+K + L KQ SE LK KNQ L+
Sbjct: 1535 EEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE--LKIKNQQLDLE 1592
Query: 186 NKQLHQKLTETQGELKDLTQKVE--LLEKFRDNCLAILESKGLDPALGSETLASRQESTT 243
N +L QK ++ Q +L++L Q++ L +K ++ + LE + E ++E
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER------EQEKFNLKEELER 1646
Query: 244 DHMDSMLLLETLQEEL 259
+ S L+ +L+ EL
Sbjct: 1647 CKVQSSTLVSSLEAEL 1662
Score = 32.3 bits (72), Expect = 0.49
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 22/185 (11%)
Query: 110 KSLLPVRSKEVDVSKQLHSGGPENDVTKITK-LRRENGQMKATDTATRRN-VRKGYKPLS 167
KS L V +E + KQ +V + K L+ G+ A + AT + + K LS
Sbjct: 1786 KSDLRVTQQEKEALKQ--------EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 168 KQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----------FRDNC 217
K + + ++ QLL N++L + T+ EL +KV LE
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1897
Query: 218 LAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL--QI 275
+ E + L + Q + M LE E + L NE KK+ +L Q+
Sbjct: 1898 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1957
Query: 276 AWMNH 280
M H
Sbjct: 1958 MEMQH 1962
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/136 (30%), Positives = 66/136 (48%), Gaps = 16/136 (11%)
Query: 132 ENDVTKITKLRRENGQMKA----TDTATRRN--VRKGYKPLSKQKSEEELKDKNQLLEAV 185
E D KL NG + T+T + N V+K + L KQ SE LK KNQ L+
Sbjct: 1535 EEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE--LKIKNQQLDLE 1592
Query: 186 NKQLHQKLTETQGELKDLTQKVE--LLEKFRDNCLAILESKGLDPALGSETLASRQESTT 243
N +L QK ++ Q +L++L Q++ L +K ++ + LE + E ++E
Sbjct: 1593 NTELSQKNSQNQEKLQELNQRLTEMLCQKEKEPGNSALEER------EQEKFNLKEELER 1646
Query: 244 DHMDSMLLLETLQEEL 259
+ S L+ +L+ EL
Sbjct: 1647 CKVQSSTLVSSLEAEL 1662
Score = 32.3 bits (72), Expect = 0.49
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 22/185 (11%)
Query: 110 KSLLPVRSKEVDVSKQLHSGGPENDVTKITK-LRRENGQMKATDTATRRN-VRKGYKPLS 167
KS L V +E + KQ +V + K L+ G+ A + AT + + K LS
Sbjct: 1786 KSDLRVTQQEKEALKQ--------EVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS 1837
Query: 168 KQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----------FRDNC 217
K + + ++ QLL N++L + T+ EL +KV LE
Sbjct: 1838 WDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGT 1897
Query: 218 LAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL--QI 275
+ E + L + Q + M LE E + L NE KK+ +L Q+
Sbjct: 1898 MNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQL 1957
Query: 276 AWMNH 280
M H
Sbjct: 1958 MEMQH 1962
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 39.7 bits (91), Expect = 0.003
Identities = 61/302 (20%), Positives = 118/302 (39%), Gaps = 35/302 (11%)
Query: 3 APEAPP--LDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEK 60
+PE P +V + T + LP ++ L + +AG L +
Sbjct: 105 SPETPDSSASKVLKREGTDTTAKTSKLPTRPASTGVAGASSSLGPSGSASAGELSSSEPS 164
Query: 61 DCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEV 120
Q A + P ++T V + S PS G A Q R + L +R K
Sbjct: 165 TPAQTPLAAPIIPTPVLTSPGAVPPLPS---PSKEEEGLRA--QVRDLEEKLETLRLKRA 219
Query: 121 DVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPL-----SKQKSEEEL 175
+ +L E ++ +++ +M+ +R +++ K +K++ EE+
Sbjct: 220 EDKAKLKE--LEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEM 277
Query: 176 KDKNQLLE--AVNKQLHQKLTET-QGELKDLTQKVELLEKFRDNCLAILESKGLDPALGS 232
D +E ++K++ ++ E+ Q E++ L ++V+ L + A +E KG D A S
Sbjct: 278 ADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASS 337
Query: 233 ETLASRQESTT------------------DHMDSMLLLETLQEELKLFNETAKKQMEELQ 274
L +E +H+ L+E +EL++ + ++ EEL
Sbjct: 338 YQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELS 397
Query: 275 IA 276
A
Sbjct: 398 QA 399
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 39.3 bits (90), Expect = 0.004
Identities = 50/202 (24%), Positives = 92/202 (45%), Gaps = 26/202 (12%)
Query: 81 SVVKTVYSLQPPSALSGGQPADTQTRA-----TSKSLLPVRSKEVDVSKQLHSGGPEND- 134
S +K+ + PS S D Q A T L VR + D ++QL E D
Sbjct: 227 SPIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQ 286
Query: 135 -VTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKL 193
V ++ K+++EN Q+ A + R + + + L++K +E +L +L
Sbjct: 287 LVLELQKVKQENIQLAADARSAR----------AYRDELDSLREKANRVE----RLELEL 332
Query: 194 TETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHM--DSMLL 251
T + +L D+ +E+ R++ + ++E+K + L + A+R H L
Sbjct: 333 TRCKEKLHDVDFYKARMEELREDNIILIETKAM---LEEQLTAARARGDKVHELEKENLQ 389
Query: 252 LETLQEELKLFNETAKKQMEEL 273
L++ +L+L +T KK++EEL
Sbjct: 390 LKSKLHDLELDRDTDKKRIEEL 411
Score = 35.8 bits (81), Expect = 0.044
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 26/122 (21%)
Query: 167 SKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDL--------------TQKVELLEK 212
S+ SE +KD +E NK LHQ +TE G+L L +K E EK
Sbjct: 577 SQVSSEARMKD----VEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEK 632
Query: 213 FRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEE 272
+ E G LA + S + + LE + L+L N T +K ++
Sbjct: 633 LERELQRLQEENG--------RLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDT 684
Query: 273 LQ 274
LQ
Sbjct: 685 LQ 686
Score = 33.5 bits (75), Expect = 0.22
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 10/140 (7%)
Query: 136 TKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTE 195
TK+ ++ REN Q++ R+NV K L K+ E L+ Q + A N +L Q L
Sbjct: 721 TKLAQMERENQQLEREKEELRKNVDL-LKALGKK--SERLELSYQSVSAENLRLQQSLES 777
Query: 196 TQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETL 255
+ + + L ++ LE R LE+ L A + + D + L
Sbjct: 778 SSHKTQTLESELGELEAERQALRRDLEALRL-------ANAQLEGAEKDRKALEQEVAQL 830
Query: 256 QEELKLFNETAKKQMEELQI 275
+++ KL + AK+ +++++
Sbjct: 831 EKDKKLLEKEAKRLWQQVEL 850
Score = 32.3 bits (72), Expect = 0.49
Identities = 48/183 (26%), Positives = 75/183 (40%), Gaps = 40/183 (21%)
Query: 132 ENDVTKITKLRRENGQMKATDTATRRNVR-------------KGYKPLSKQKSEEELKDK 178
E+ K L E G+++A A RR++ K K L ++ ++ E KDK
Sbjct: 776 ESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLE-KDK 834
Query: 179 NQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALG--SETLA 236
+LLE K+L Q++ L D T K+ +EK ES+ LD L +
Sbjct: 835 -KLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEK---------ESRALDKELARCRDAAG 884
Query: 237 SRQESTTDHMD-------SMLLLETLQEELKL-------FNETAKKQMEELQIAWMNHGI 282
+E D+ D L TL+E+L L + K +EL+ +N +
Sbjct: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944
Query: 283 LHQ 285
L Q
Sbjct: 945 LLQ 947
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 38.5 bits (88), Expect = 0.007
Identities = 55/187 (29%), Positives = 83/187 (44%), Gaps = 25/187 (13%)
Query: 96 SGGQPAD-TQTRATSKSLLPVRSKEVDVSK----QLHSGGPENDVTKITKLRRENGQMKA 150
SG AD Q S++LL KEV +L + E+ V + T LRREN ++
Sbjct: 1461 SGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQET-LRRENKNLQE 1519
Query: 151 TDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQG-----ELKDLTQ 205
+ VR+G K L+ E++ +L+E ++ L ET+G E K L
Sbjct: 1520 EISNLTNQVREGTKNLT------EMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHF 1573
Query: 206 KVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNET 265
++ELLE A LE K + E +Q+ T D + S L E + ++
Sbjct: 1574 QLELLE-----AKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEA---KSRIEVTR 1625
Query: 266 AKKQMEE 272
KK+MEE
Sbjct: 1626 LKKKMEE 1632
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 38.1 bits (87), Expect = 0.009
Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 33/263 (12%)
Query: 40 AADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQ 99
++ L + +AG L + Q A + P ++T V + S PS G
Sbjct: 30 SSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPS---PSKEEEGL 86
Query: 100 PADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNV 159
A Q R + L +R K + +L E ++ +++ +M+ +R +
Sbjct: 87 RA--QVRDLEEKLETLRLKRAEDKAKLKE--LEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 160 RKGYKPL-----SKQKSEEELKDKNQLLE--AVNKQLHQKLTET-QGELKDLTQKVELLE 211
++ K +K++ EE+ D +E ++K++ ++ E+ Q E++ L ++V+ L
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 212 KFRDNCLAILESKGLDPALGSETLASRQESTT------------------DHMDSMLLLE 253
+ A +E KG D A S L +E +H+ L+E
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 262
Query: 254 TLQEELKLFNETAKKQMEELQIA 276
+EL++ + ++ EEL A
Sbjct: 263 KKNQELEVVRQQRERLQEELSQA 285
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 38.1 bits (87), Expect = 0.009
Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 33/263 (12%)
Query: 40 AADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQ 99
++ L + +AG L + Q A + P ++T V + S PS G
Sbjct: 30 SSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPS---PSKEEEGL 86
Query: 100 PADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNV 159
A Q R + L +R K + +L E ++ +++ +M+ +R +
Sbjct: 87 RA--QVRDLEEKLETLRLKRAEDKAKLKE--LEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 160 RKGYKPL-----SKQKSEEELKDKNQLLE--AVNKQLHQKLTET-QGELKDLTQKVELLE 211
++ K +K++ EE+ D +E ++K++ ++ E+ Q E++ L ++V+ L
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202
Query: 212 KFRDNCLAILESKGLDPALGSETLASRQESTT------------------DHMDSMLLLE 253
+ A +E KG D A S L +E +H+ L+E
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 262
Query: 254 TLQEELKLFNETAKKQMEELQIA 276
+EL++ + ++ EEL A
Sbjct: 263 KKNQELEVVRQQRERLQEELSQA 285
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 38.1 bits (87), Expect = 0.009
Identities = 54/263 (20%), Positives = 107/263 (40%), Gaps = 33/263 (12%)
Query: 40 AADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQPPSALSGGQ 99
++ L + +AG L + Q A + P ++T V + S PS G
Sbjct: 164 SSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPS---PSKEEEGL 220
Query: 100 PADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNV 159
A Q R + L +R K + +L E ++ +++ +M+ +R +
Sbjct: 221 RA--QVRDLEEKLETLRLKRAEDKAKLKE--LEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
Query: 160 RKGYKPL-----SKQKSEEELKDKNQLLE--AVNKQLHQKLTET-QGELKDLTQKVELLE 211
++ K +K++ EE+ D +E ++K++ ++ E+ Q E++ L ++V+ L
Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 336
Query: 212 KFRDNCLAILESKGLDPALGSETLASRQESTT------------------DHMDSMLLLE 253
+ A +E KG D A S L +E +H+ L+E
Sbjct: 337 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 396
Query: 254 TLQEELKLFNETAKKQMEELQIA 276
+EL++ + ++ EEL A
Sbjct: 397 KKNQELEVVRQQRERLQEELSQA 419
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 38.1 bits (87), Expect = 0.009
Identities = 38/145 (26%), Positives = 73/145 (50%), Gaps = 21/145 (14%)
Query: 132 ENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQ 191
+N ++ L +EN Q+ + RRNV + K S + ++ +L++K LE+ +QL +
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNV-ESLKCASMKMAQLQLENKE--LESEKEQLKK 739
Query: 192 KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLL 251
L + K K E LE + +GLD + ++ L E++ +
Sbjct: 740 GLELLKASFK----KTERLE---------VSYQGLD--IENQRLQKTLENSNKKIQQ--- 781
Query: 252 LETLQEELKLFNETAKKQMEELQIA 276
LE+ ++L++ N+T +K +EEL+I+
Sbjct: 782 LESELQDLEMENQTLQKNLEELKIS 806
Score = 37.7 bits (86), Expect = 0.012
Identities = 44/171 (25%), Positives = 75/171 (43%), Gaps = 18/171 (10%)
Query: 116 RSKEVDVSKQLHSGGPENDVT--KITKLRRENGQMKATDTATRRNVRK----GYKPLSKQ 169
R+ E+ + Q G N++T ++ KL EN + T R V K L +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 170 KSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----FRDNC---LAILE 222
K + L K ++LE Q Q L Q KDL ++ LEK R+N + ILE
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 223 SKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL 273
+ + L + RQ S + + ++ +++E K+ +E+ K+ +L
Sbjct: 558 QE--NEHLNQTVSSLRQRS---QISAEARVKDIEKENKILHESIKETSSKL 603
Score = 31.6 bits (70), Expect = 0.84
Identities = 45/185 (24%), Positives = 75/185 (40%), Gaps = 34/185 (18%)
Query: 113 LPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVR------------ 160
L V + +D+ Q EN KI +L E ++ + ++N+
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 161 -KGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK------- 212
K K L ++ S+ E KDK QL E NK+L Q+ L++ K+ LEK
Sbjct: 814 EKENKSLEQETSQLE-KDKKQL-EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 213 ----FRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKK 268
++++C+ + E L E + +T D + L E L E KL +
Sbjct: 872 EIGIYKESCVRLKE-------LEKENKELVKRATIDIKTLVTLREDLVSE-KLKTQQMNN 923
Query: 269 QMEEL 273
+E+L
Sbjct: 924 DLEKL 928
Score = 29.6 bits (65), Expect = 3.2
Identities = 30/139 (21%), Positives = 70/139 (50%), Gaps = 15/139 (10%)
Query: 137 KITKLRRENGQMKATDTATRRNV---RKGYKPLSK-QKSEEELKDKNQLLEAVNKQLHQK 192
K+ +L+ EN ++++ ++ + + +K + + S + L +NQ L+ + ++K
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 193 LTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLL 252
+ + + EL+DL + + L+K + + SK L+ L E + QE++ L
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELK--ISSKRLE-QLEKENKSLEQETSQ--------L 827
Query: 253 ETLQEELKLFNETAKKQME 271
E +++L+ N+ ++Q E
Sbjct: 828 EKDKKQLEKENKRLRQQAE 846
Score = 28.5 bits (62), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 12/81 (14%)
Query: 132 ENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQ 191
EN +I L +EN + T ++ R+ S+ +E +KD +E NK LH+
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQR--------SQISAEARVKD----IEKENKILHE 594
Query: 192 KLTETQGELKDLTQKVELLEK 212
+ ET +L + + ++K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKK 615
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 38.1 bits (87), Expect = 0.009
Identities = 38/145 (26%), Positives = 73/145 (50%), Gaps = 21/145 (14%)
Query: 132 ENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQ 191
+N ++ L +EN Q+ + RRNV + K S + ++ +L++K LE+ +QL +
Sbjct: 683 KNLTFQLESLEKENSQLDEENLELRRNV-ESLKCASMKMAQLQLENKE--LESEKEQLKK 739
Query: 192 KLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLL 251
L + K K E LE + +GLD + ++ L E++ +
Sbjct: 740 GLELLKASFK----KTERLE---------VSYQGLD--IENQRLQKTLENSNKKIQQ--- 781
Query: 252 LETLQEELKLFNETAKKQMEELQIA 276
LE+ ++L++ N+T +K +EEL+I+
Sbjct: 782 LESELQDLEMENQTLQKNLEELKIS 806
Score = 37.7 bits (86), Expect = 0.012
Identities = 44/171 (25%), Positives = 75/171 (43%), Gaps = 18/171 (10%)
Query: 116 RSKEVDVSKQLHSGGPENDVT--KITKLRRENGQMKATDTATRRNVRK----GYKPLSKQ 169
R+ E+ + Q G N++T ++ KL EN + T R V K L +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 170 KSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK----FRDNC---LAILE 222
K + L K ++LE Q Q L Q KDL ++ LEK R+N + ILE
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 223 SKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQMEEL 273
+ + L + RQ S + + ++ +++E K+ +E+ K+ +L
Sbjct: 558 QE--NEHLNQTVSSLRQRS---QISAEARVKDIEKENKILHESIKETSSKL 603
Score = 31.6 bits (70), Expect = 0.84
Identities = 45/185 (24%), Positives = 75/185 (40%), Gaps = 34/185 (18%)
Query: 113 LPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVR------------ 160
L V + +D+ Q EN KI +L E ++ + ++N+
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 161 -KGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEK------- 212
K K L ++ S+ E KDK QL E NK+L Q+ L++ K+ LEK
Sbjct: 814 EKENKSLEQETSQLE-KDKKQL-EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 213 ----FRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKK 268
++++C+ + E L E + +T D + L E L E KL +
Sbjct: 872 EIGIYKESCVRLKE-------LEKENKELVKRATIDIKTLVTLREDLVSE-KLKTQQMNN 923
Query: 269 QMEEL 273
+E+L
Sbjct: 924 DLEKL 928
Score = 29.6 bits (65), Expect = 3.2
Identities = 30/139 (21%), Positives = 70/139 (50%), Gaps = 15/139 (10%)
Query: 137 KITKLRRENGQMKATDTATRRNV---RKGYKPLSK-QKSEEELKDKNQLLEAVNKQLHQK 192
K+ +L+ EN ++++ ++ + + +K + + S + L +NQ L+ + ++K
Sbjct: 719 KMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK 778
Query: 193 LTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLL 252
+ + + EL+DL + + L+K + + SK L+ L E + QE++ L
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELK--ISSKRLE-QLEKENKSLEQETSQ--------L 827
Query: 253 ETLQEELKLFNETAKKQME 271
E +++L+ N+ ++Q E
Sbjct: 828 EKDKKQLEKENKRLRQQAE 846
Score = 28.5 bits (62), Expect = 7.1
Identities = 21/81 (25%), Positives = 38/81 (46%), Gaps = 12/81 (14%)
Query: 132 ENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQ 191
EN +I L +EN + T ++ R+ S+ +E +KD +E NK LH+
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQR--------SQISAEARVKD----IEKENKILHE 594
Query: 192 KLTETQGELKDLTQKVELLEK 212
+ ET +L + + ++K
Sbjct: 595 SIKETSSKLSKIEFEKRQIKK 615
>gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo
sapiens]
Length = 395
Score = 38.1 bits (87), Expect = 0.009
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 19/140 (13%)
Query: 148 MKATDTATRRNVRKGYKPLSKQ-KSEEE---LKDKNQLLEAVNKQLHQKLTETQGELKDL 203
+K A ++ Y+ + +Q KSE+E LKD + +A +++L QKL + EL+ L
Sbjct: 222 LKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERF-QARSQELEQKLLCKEQELEQL 280
Query: 204 TQKVELLEKFRDNCLAILESKGLDPA------LGSETLASRQESTT-DHMDSMLLLETLQ 256
TQK + LE C A+ K A L ++ LA E T+ + D+ LE+LQ
Sbjct: 281 TQKQKRLE---GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ 337
Query: 257 EE-LKLFNETAKKQMEELQI 275
+E KL E K+ME ++
Sbjct: 338 QEACKLHQE---KEMEVYRV 354
Score = 28.9 bits (63), Expect = 5.4
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)
Query: 140 KLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGE 199
K +E +K T+ R+ K L K++ E+L K + LE LH ET+ E
Sbjct: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAE 304
Query: 200 LKDL-TQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE 258
L EL + + +++ +L E QE M+ + E+LQ E
Sbjct: 305 NTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK---EMEVYRVTESLQRE 361
>gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
sapiens]
Length = 462
Score = 38.1 bits (87), Expect = 0.009
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 19/140 (13%)
Query: 148 MKATDTATRRNVRKGYKPLSKQ-KSEEE---LKDKNQLLEAVNKQLHQKLTETQGELKDL 203
+K A ++ Y+ + +Q KSE+E LKD + +A +++L QKL + EL+ L
Sbjct: 222 LKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERF-QARSQELEQKLLCKEQELEQL 280
Query: 204 TQKVELLEKFRDNCLAILESKGLDPA------LGSETLASRQESTT-DHMDSMLLLETLQ 256
TQK + LE C A+ K A L ++ LA E T+ + D+ LE+LQ
Sbjct: 281 TQKQKRLE---GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ 337
Query: 257 EE-LKLFNETAKKQMEELQI 275
+E KL E K+ME ++
Sbjct: 338 QEACKLHQE---KEMEVYRV 354
Score = 28.9 bits (63), Expect = 5.4
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)
Query: 140 KLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGE 199
K +E +K T+ R+ K L K++ E+L K + LE LH ET+ E
Sbjct: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAE 304
Query: 200 LKDL-TQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE 258
L EL + + +++ +L E QE M+ + E+LQ E
Sbjct: 305 NTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK---EMEVYRVTESLQRE 361
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 38.1 bits (87), Expect = 0.009
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 19/140 (13%)
Query: 148 MKATDTATRRNVRKGYKPLSKQ-KSEEE---LKDKNQLLEAVNKQLHQKLTETQGELKDL 203
+K A ++ Y+ + +Q KSE+E LKD + +A +++L QKL + EL+ L
Sbjct: 222 LKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERF-QARSQELEQKLLCKEQELEQL 280
Query: 204 TQKVELLEKFRDNCLAILESKGLDPA------LGSETLASRQESTT-DHMDSMLLLETLQ 256
TQK + LE C A+ K A L ++ LA E T+ + D+ LE+LQ
Sbjct: 281 TQKQKRLE---GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ 337
Query: 257 EE-LKLFNETAKKQMEELQI 275
+E KL E K+ME ++
Sbjct: 338 QEACKLHQE---KEMEVYRV 354
Score = 28.9 bits (63), Expect = 5.4
Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 4/120 (3%)
Query: 140 KLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGE 199
K +E +K T+ R+ K L K++ E+L K + LE LH ET+ E
Sbjct: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAE 304
Query: 200 LKDL-TQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE 258
L EL + + +++ +L E QE M+ + E+LQ E
Sbjct: 305 NTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK---EMEVYRVTESLQRE 361
>gi|31542661 transmembrane protein 57 [Homo sapiens]
Length = 664
Score = 38.1 bits (87), Expect = 0.009
Identities = 34/137 (24%), Positives = 67/137 (48%), Gaps = 14/137 (10%)
Query: 140 KLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQLLEAVNKQLHQKLTETQGE 199
+L E + K + R V + S+ + E L+++ + LEA K+L + + +
Sbjct: 473 QLMEEKKRKKLEEATAARAV--AFAAASRGECTETLRNRIRELEAEGKKLTMDMKVKEDQ 530
Query: 200 LKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEEL 259
+++L KV+ L K+++N K + + + S + T H+++ L ET + +L
Sbjct: 531 IRELELKVQELRKYKEN------EKDTEVLMSA---LSAMQDKTQHLENSLSAET-RIKL 580
Query: 260 KLFNE--TAKKQMEELQ 274
LF+ AK+Q+E Q
Sbjct: 581 DLFSALGDAKRQLEIAQ 597
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 38.1 bits (87), Expect = 0.009
Identities = 29/105 (27%), Positives = 54/105 (51%), Gaps = 5/105 (4%)
Query: 137 KITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEEL-KDKNQLLEAVNKQLHQKLTE 195
++ KLR E ++ A +TA + + K +++ E EL K + + +VN + +
Sbjct: 749 ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQ 808
Query: 196 TQGELKDLTQKVELL-EKFRDNCLAILESKGLDPALGSETLASRQ 239
EL+ + +++E+L E++ C LE+ L AL +E A RQ
Sbjct: 809 YLEELQSVQRELEVLSEQYSQKC---LENAHLAQALEAERQALRQ 850
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,915,319
Number of Sequences: 37866
Number of extensions: 461454
Number of successful extensions: 2800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 291
Number of HSP's that attempted gapping in prelim test: 2309
Number of HSP's gapped (non-prelim): 793
length of query: 286
length of database: 18,247,518
effective HSP length: 101
effective length of query: 185
effective length of database: 14,423,052
effective search space: 2668264620
effective search space used: 2668264620
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.