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Search of human proteins with 218083720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo
sapiens]
(440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo s... 862 0.0
gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo s... 857 0.0
gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo sa... 537 e-153
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 70 4e-12
gi|242332545 coiled-coil domain containing 121-like [Homo sapiens] 69 6e-12
gi|16262452 cingulin [Homo sapiens] 68 2e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 66 7e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 66 7e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 66 7e-11
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 66 7e-11
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 66 7e-11
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 66 7e-11
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 66 7e-11
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 66 7e-11
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 64 3e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 63 5e-10
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 1e-09
gi|148746195 trichohyalin [Homo sapiens] 59 7e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 59 7e-09
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 59 1e-08
gi|221139761 zinc finger protein 853 [Homo sapiens] 58 1e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 3e-08
gi|50083279 centrosome protein 4 [Homo sapiens] 57 3e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 57 3e-08
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 57 3e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 57 3e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 57 3e-08
gi|166295204 hypothetical protein LOC80127 [Homo sapiens] 57 4e-08
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 57 4e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 56 6e-08
>gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo
sapiens]
Length = 440
Score = 862 bits (2228), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL
Sbjct: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
Query: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL
Sbjct: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
Query: 121 DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL 180
DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL
Sbjct: 121 DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL 180
Query: 181 LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR 240
LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR
Sbjct: 181 LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR 240
Query: 241 YAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK 300
YAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK
Sbjct: 241 YAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK 300
Query: 301 TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRE 360
TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRE
Sbjct: 301 TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRE 360
Query: 361 NQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
NQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ
Sbjct: 361 NQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
Query: 421 DVPKTTPSLPQGTKSRINPK 440
DVPKTTPSLPQGTKSRINPK
Sbjct: 421 DVPKTTPSLPQGTKSRINPK 440
>gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo
sapiens]
Length = 442
Score = 857 bits (2215), Expect = 0.0
Identities = 440/442 (99%), Positives = 440/442 (99%), Gaps = 2/442 (0%)
Query: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL
Sbjct: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
Query: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL
Sbjct: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
Query: 121 DSR--FAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 178
DSR FAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK
Sbjct: 121 DSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 180
Query: 179 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 238
QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA
Sbjct: 181 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
Query: 239 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 298
SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA
Sbjct: 241 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 300
Query: 299 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 358
SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN
Sbjct: 301 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
Query: 359 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 418
RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN
Sbjct: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 420
Query: 419 RQDVPKTTPSLPQGTKSRINPK 440
RQDVPKTTPSLPQGTKSRINPK
Sbjct: 421 RQDVPKTTPSLPQGTKSRINPK 442
>gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo
sapiens]
Length = 278
Score = 537 bits (1384), Expect = e-153
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 163 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 222
MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS
Sbjct: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
Query: 223 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 282
YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE
Sbjct: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
Query: 283 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 342
IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL
Sbjct: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
Query: 343 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 402
KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL
Sbjct: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
Query: 403 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 440
IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK
Sbjct: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 70.1 bits (170), Expect = 4e-12
Identities = 77/279 (27%), Positives = 145/279 (51%), Gaps = 22/279 (7%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN-RFFLEY 204
E+L ++E ++K+ +AE T L ++ A K L+E+ L ++K +V AE R E
Sbjct: 325 ERLQELE-KIKDLHMAEKTKLITQLRDA----KNLIEQ---LEQDKGMVIAETKRQMHET 376
Query: 205 LTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKR 264
L K EE + ++ + GE R ++E + R A L+ AL + + + +R
Sbjct: 377 LEMKEEEIAQLRSRI--KQMTTQGEELREQKEKSERAA--FEELEKALSTAQKTEEA-RR 431
Query: 265 KLQAMRD--IAILKEKQEKEIQTLQEETKKVQAETAS-KTREVQAQLLQEKRLLEKQLSE 321
KL+A D I +++ E+E +LQ+E +V+ E + + Q+ + ++L EK+L+
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491
Query: 322 PDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTAT 381
++ L K + RE + Q +K+A ++ EY I++E +Q + L+ +E +K T
Sbjct: 492 KEQELTKKLQTREREFQEQ-MKVALEKSQSEY-LKISQEKEQQESLALEELELQKKAILT 549
Query: 382 QSHLENRKQQLQQE-QWYLESLIQARQRLQGSHNQCLNR 419
+S EN+ + LQQE + Y +++ L+ S + N+
Sbjct: 550 ES--ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Score = 57.4 bits (137), Expect = 3e-08
Identities = 63/307 (20%), Positives = 140/307 (45%), Gaps = 32/307 (10%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN----RFF 201
EK+ + K K++ ++ D I+Q + + ++ E++ E L ++ E R
Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
Query: 202 LEYLTNKTEEYTEQPEKVWNSYLQK-------SGEIERRRQESASRYAEQISVL-KTALL 253
++ +T + EE EQ EK + ++ + + E R++ + EQI + KT+
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 254 QKENIQSSLKRKLQAMRDIAILK-EKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEK 312
++ ++Q L R Q + D+ E+Q ++Q L E+ + + +K + + + QE+
Sbjct: 451 ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 313 RLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS---CGINRENQQFKKELL 369
+ + S+ + + + K ++ ++ + L+L K + E + +E + ++ +L
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 370 QL---IEQAQKLTATQS-----HLENRKQQ--------LQQEQWYLESLIQARQRLQGSH 413
+L +E++ + QS HLE K + +++ + LESL + L
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630
Query: 414 NQCLNRQ 420
Q L +Q
Sbjct: 631 LQVLKQQ 637
Score = 49.3 bits (116), Expect = 7e-06
Identities = 63/278 (22%), Positives = 114/278 (41%), Gaps = 33/278 (11%)
Query: 156 KEKIVAEMTDLNKHIKQAQTQ----RKQLLEESRELHREKLLVQAENRFF------LEYL 205
K+K + T +K+ Q Q K+ E+ +++ K + +N+ F +E
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 206 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 265
+K E+ E S + E+E + VLK QK+ L +K
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 266 LQAMRDIAILKEKQEKE----IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSE 321
LQ +++ K+ + KE I TL+ + ++AE +K +E++ L K E
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS------KE 1619
Query: 322 PDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIE--QAQKLT 379
+ + L R E K LK A++ I KK+LL +E + Q
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKI-----------AAIKKQLLSQMEEKEEQYKK 1668
Query: 380 ATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCL 417
T+SHL +LQ+ + + L + + ++ S ++ L
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Score = 47.0 bits (110), Expect = 3e-05
Identities = 66/315 (20%), Positives = 142/315 (45%), Gaps = 40/315 (12%)
Query: 144 KPEKLTK-VETRLKE-----KIVAEMTDLNK-HIKQAQTQRKQLLEESRELHREKLLVQA 196
K ++LTK ++TR +E K+ E + I Q + Q++ L E EL ++ +L ++
Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551
Query: 197 ENRFFLEYLTNKTEEYTEQP-------EKVWNSYLQKSGEIERRRQESASRYAEQISVL- 248
EN+ L L + E Y + EK +S ++ + +++ ++I+V+
Sbjct: 552 ENK--LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV 609
Query: 249 ---KTALLQKENIQSSL-KRKLQAMR-----DIAILKEKQEKEIQTLQEETKKVQAETAS 299
KT L ++ Q +L KLQ ++ ++ L+EK E+E +TL ++ + +
Sbjct: 610 EKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 669
Query: 300 KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR 359
+ E + L K+ + LS +L + R +L + LK + E ++
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVL--KARHKLEEELSVLKDQTDKMKQELEAKMDE 727
Query: 360 ENQQFKKELLQLIEQAQ------------KLTATQSHLENRKQQLQQEQWYLESLIQARQ 407
+ ++++ +I++ + ++ + L+ R + L++ Q ++E+L +
Sbjct: 728 QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIK 787
Query: 408 RLQGSHNQCLNRQDV 422
R +G Q + DV
Sbjct: 788 RSEGELQQASAKLDV 802
Score = 46.6 bits (109), Expect = 4e-05
Identities = 67/332 (20%), Positives = 141/332 (42%), Gaps = 22/332 (6%)
Query: 116 QDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQT 175
Q E +S + + L Y S + + K ++ TK KE ++ +M + K + T
Sbjct: 869 QLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILT 928
Query: 176 QRKQLLEESRELHREKLLVQAENR-FFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRR 234
Q+ E+S + E+ + +N+ +E + K +E E +K L + ++++
Sbjct: 929 QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK---KLLDQEAKLKKEL 985
Query: 235 QESASRYAEQ-----ISVLKTALLQKENIQSSLKR-KLQAMRDIAILKEKQEKEIQTLQE 288
+ +A +++ +L+ A I ++ R + I L E +E+ +
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVIS 1045
Query: 289 ETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRR-LLGKRKRRELNMKAQALKLAAK 347
+K + A + +E+ LQEK E++++E ++ LL ++ E+N + LK
Sbjct: 1046 IWEKKLNQQAEELQEIHEIQLQEK---EQEVAELKQKILLFGCEKEEMNKEITWLKEEG- 1101
Query: 348 RFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE----NRKQQLQQEQWYLESLI 403
+ +N +Q K++ + AQ T ++HLE + + L++ + E L+
Sbjct: 1102 ---VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV 1158
Query: 404 QARQRLQGSHNQCLNRQDVPKTTPSLPQGTKS 435
+ + + + KTT Q KS
Sbjct: 1159 ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Score = 40.8 bits (94), Expect = 0.002
Identities = 62/263 (23%), Positives = 120/263 (45%), Gaps = 23/263 (8%)
Query: 148 LTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTN 207
L + ET+LK + DLNK +K+ ++QL+E K+L + + R E LT+
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE-------LKMLAEEDKRKVSE-LTS 1176
Query: 208 KTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 267
K + E+ + + +S+ + + +E + E + +E++++ +K ++ L+ K
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKSLEDKSLE-FKKLSEELAIQLDICCKK--TEALLEAKTN 1233
Query: 268 AMRDIAILKEKQ-EKEIQTLQEETKKVQAETASKT---REVQAQLLQ---EKRLLEKQLS 320
+ +I+ K I Q T KV+ KT E++AQL Q E+ L
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 321 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQK-LT 379
+ +L K + + +MKA L ++ + G QQ E I Q +K L+
Sbjct: 1294 QATHQLEEKENQIK-SMKADIESLVTEKEALQKEGG---NQQQAASEKESCITQLKKELS 1349
Query: 380 ATQSHLENRKQQLQQEQWYLESL 402
+ + K++L++++ + SL
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSL 1372
Score = 40.0 bits (92), Expect = 0.004
Identities = 50/247 (20%), Positives = 115/247 (46%), Gaps = 26/247 (10%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K + K+ + D+ K +++ + + L ++ +EL + + +R +E LT+K
Sbjct: 1822 KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY 1881
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ Q + + + + +E +E + + Q +L Q +++ L A
Sbjct: 1882 EKL--QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG---AE 1936
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R+ K+K KEI LQ++ + ++ E QE +L+K+ + +R K
Sbjct: 1937 RE----KQKLGKEIVRLQKDLRMLRKEHQ-----------QELEILKKEYDQ-EREEKIK 1980
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA--TQSHLEN 387
+++ +L +K + K+ + E++ + ++ Q+ + + + I +AQ++ A +SH E
Sbjct: 1981 QEQEDLELKHNS---TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEE 2037
Query: 388 RKQQLQQ 394
Q L++
Sbjct: 2038 TNQLLKK 2044
Score = 34.7 bits (78), Expect = 0.18
Identities = 69/319 (21%), Positives = 124/319 (38%), Gaps = 58/319 (18%)
Query: 144 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQ-RKQLL---EESRELHRE--------- 190
K E+L +E RL+ + A++ +L + +Q +KQLL EE E +++
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 191 --KLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS----RYAEQ 244
KL + LE E + V S + E+ +S Y E+
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 245 ISVLKTALLQK------------ENIQSSLKRKLQAMRDIAILKEKQEKE---------- 282
ISVL+ L +K E + S + + Q + L+ + K+
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797
Query: 283 IQTLQEETKKVQAETASKT-REVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 341
+ L+E+ KK A +E +Q K+ LE + + L +E + Q
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL------QEKELTCQI 1851
Query: 342 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQS-HLENRKQQLQQEQWYLE 400
L+ K E + R+ + + E+ +L + +KL A Q N+ +L +E +
Sbjct: 1852 LEQKIK----ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907
Query: 401 S---LIQAR--QRLQGSHN 414
S L+Q + ++ HN
Sbjct: 1908 SKSHLVQPKLLSNMEAQHN 1926
Score = 32.0 bits (71), Expect = 1.1
Identities = 46/226 (20%), Positives = 99/226 (43%), Gaps = 49/226 (21%)
Query: 224 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ---------------- 267
+++ + +R +E+ + EQ ++L + +KE +Q L +LQ
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLLTS---EKEALQEQLDERLQELEKIKDLHMAEKTKL 344
Query: 268 --AMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------LQEK 312
+RD L E+ E++ + ETK+ ET E AQL L+E+
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 313 R---------LLEKQLSEPDRRLLGKRK-RRELNMKAQALKLAAKRFIFEYSCGINRENQ 362
+ LEK LS + +RK + E++ + + ++ ++ E + +E
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE----EERISLQQELS 460
Query: 363 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQR 408
+ K+E++ +++++ + + + K+ ++EQ L +Q R+R
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ-ELTKKLQTRER 505
Score = 32.0 bits (71), Expect = 1.1
Identities = 34/129 (26%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSE-LHSCRDLQDECLDSRFAEGPR 129
E +L+ STL RE TQ+ L +T+ E ++ ++++ E L+S E
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQ-KEQELEMTIKETINKAQEVEAELLESH-QEETN 2039
Query: 130 RLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHR 189
+LL K + L + R +E + A ++ ++ QTQ LEE ++ ++
Sbjct: 2040 QLLKKIAE------KDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ----LEELQKKYQ 2089
Query: 190 EKLLVQAEN 198
+K L Q EN
Sbjct: 2090 QK-LEQEEN 2097
>gi|242332545 coiled-coil domain containing 121-like [Homo sapiens]
Length = 439
Score = 69.3 bits (168), Expect = 6e-12
Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)
Query: 166 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
L++ + + Q+L E+ L RE L ++ ENR + Y++ + + + ++
Sbjct: 41 LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+I +R E AS Y + ++ LL+ E + + +++Q ++ +L+ +Q I+
Sbjct: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 345
L+ E ++ E V+ + L++K E++ + + L +R RE
Sbjct: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
Query: 346 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
A R + ++ I +N + ++ELL L+ + Q L T+ L +++QL +E
Sbjct: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 67.8 bits (164), Expect = 2e-11
Identities = 79/349 (22%), Positives = 151/349 (43%), Gaps = 62/349 (17%)
Query: 104 VTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEM 163
V L +L R+L +E L EG +R+ ++ +LT ++ LKE++ +
Sbjct: 464 VLLKDLLETRELLEEVL-----EGKQRVEEQLR------LRERELTALKGALKEEVASRD 512
Query: 164 TDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV--WN 221
++ +Q Q +QL ++ ++ +++AE + + E E E+ W
Sbjct: 513 QEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ 572
Query: 222 SYLQKSGE-----------IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 270
S QK+ E + ++E E+I VL+ L Q + R
Sbjct: 573 SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-------RASAGDTR 625
Query: 271 DIAILKEKQEKEIQTLQEETKKVQAETAS-------KTREVQAQL------------LQE 311
+ +LK KE+ QEE K++QAE S + RE++ QL L+E
Sbjct: 626 QVEVLK----KELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE 681
Query: 312 KRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSC-GINRENQQFKKELLQ 370
+ L ++ + R+ + + ++ +A+A L +R E + EN +F++ +L
Sbjct: 682 QNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG 741
Query: 371 LIEQAQKL-------TATQSHLENRKQQLQQEQWYLESLIQARQRLQGS 412
L +Q ++ A ++ L ++ Q+L+ E+ LE + A Q +GS
Sbjct: 742 LEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Score = 49.7 bits (117), Expect = 5e-06
Identities = 59/242 (24%), Positives = 104/242 (42%), Gaps = 30/242 (12%)
Query: 202 LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+E L K +E ++ +K+ S + ++E + +E SR E + K Q +
Sbjct: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEE-CSRLQELLERRKGEAQQSNKELQN 426
Query: 262 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK---------TREVQAQLLQEK 312
+KR L D L+ E ++ LQ + K VQ +K TRE+ ++L+ K
Sbjct: 427 MKRLLDQGED---LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK 483
Query: 313 RLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLI 372
+ +E+QL + + REL ALK A K + + QQ++++ QL
Sbjct: 484 QRVEEQL---------RLRERELT----ALKGALKEEVASRDQEVEHVRQQYQRDTEQLR 530
Query: 373 EQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCL---NRQDVPKTTPSL 429
Q T + LE +Q++ L+ ++ G H Q + N++D+ T L
Sbjct: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETG-HWQSMFQKNKEDLRATKQEL 589
Query: 430 PQ 431
Q
Sbjct: 590 LQ 591
Score = 43.1 bits (100), Expect = 5e-04
Identities = 52/249 (20%), Positives = 109/249 (43%), Gaps = 30/249 (12%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYL 205
E+ ++ R +++ E+ + + KQA Q + LE+ +E R + + A+
Sbjct: 841 EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE-VADAQ-------- 891
Query: 206 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 265
+ +++ + EK + EI+R RQ + AE+ TA L KE + L+
Sbjct: 892 -RQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAER----DTARLDKELLAQRLQGL 946
Query: 266 LQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRR 325
Q + ++ + ++++ L+E+ +++ E + V+ L Q+ +
Sbjct: 947 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL-LTDRVNRGRDQVDQLRTE 1005
Query: 326 LLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHL 385
L+ +R R+ +++ + L R+N+ K L E QK +A+ S L
Sbjct: 1006 LMQERSARQ-DLECDKISL-------------ERQNKDLKTRLAS-SEGFQKPSASLSQL 1050
Query: 386 ENRKQQLQQ 394
E++ Q LQ+
Sbjct: 1051 ESQNQLLQE 1059
Score = 41.2 bits (95), Expect = 0.002
Identities = 59/279 (21%), Positives = 123/279 (44%), Gaps = 50/279 (17%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
+TR E + E+ + +K+ Q +R+ +E HR++ L + L ++ E
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQS--QEVAGRHRDREL--EKQLAVLRVEADRGRE 678
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASR-----------YAEQISVLKTALLQKENIQS 260
EQ N LQK+ + R+ E AS+ ++ + ++T L + +
Sbjct: 679 LEEQ-----NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEND 733
Query: 261 SLKRKL----QAMRDIAILKEKQEKEIQTLQEETKKVQAE------TASKTREVQAQLLQ 310
+R++ Q +++ L + E L+++ ++++AE + ++E + L
Sbjct: 734 EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAA 793
Query: 311 EKRLLEKQLSEPDRRL--LGKR------------KRRELNMKAQALKLAAKRFIFEYSCG 356
KR LE +L E R L LG+ K+RE+ + +A KR +
Sbjct: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDR 853
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+N+E ++ ++ Q ++Q Q+ LE+ K++ ++E
Sbjct: 854 LNKELEKIGEDSKQALQQ------LQAQLEDYKEKARRE 886
Score = 35.8 bits (81), Expect = 0.079
Identities = 62/276 (22%), Positives = 111/276 (40%), Gaps = 41/276 (14%)
Query: 154 RLKEKIVAEMT--DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
RL++ + A D + K+ QR Q LE+ E K Q + L+ L K
Sbjct: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAE---NKKRSQDDRARQLKGLEEKVSR 973
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK-RKLQAMR 270
+ ++ N+ + + R R +Q+ L+T L+Q+ + + L+ K+ R
Sbjct: 974 LETELDEEKNTVELLTDRVNRGR--------DQVDQLRTELMQERSARQDLECDKISLER 1025
Query: 271 DIAILKEKQ----------------EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 314
LK + E + Q LQE ++QAE KT E+++
Sbjct: 1026 QNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE---RLQAEEREKTVLQSTNRKLERKV 1082
Query: 315 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ 374
E + D R ++ +L+++ +AL KR + E I R + KK ++ EQ
Sbjct: 1083 KELSIQIEDERQHVNDQKDQLSLRVKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Query: 375 AQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 410
+ L+ R + L+++ W S A L+
Sbjct: 1139 HE----VNEQLQARIKSLEKDSWRKASRSAAESALK 1170
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2271 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2316
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2437 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2546
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1360 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1414
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1415 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2119
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE 2145
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1596
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1652
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1653 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1709
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1710 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1764 ---MEVLLASKARAE 1775
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1985 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2028
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2087 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2137 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2235
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 391 QLQQE 395
+++
Sbjct: 2296 LAEED 2300
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1694
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1041
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1222 WLQDARRRQEQIQ 1234
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2275 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2320
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2441 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2550
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2601
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1364 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1418
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1419 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1475
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1595
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2123
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQE 2149
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1600
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1656
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1657 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1713
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1714 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1768 ---MEVLLASKARAE 1779
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1989 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2032
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2091 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2141 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2120
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2239
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299
Query: 391 QLQQE 395
+++
Sbjct: 2300 LAEED 2304
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1698
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRK 1904
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1114 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1229
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 987 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1045
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1046 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1105
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1226 WLQDARRRQEQIQ 1238
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2271 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2316
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2437 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2546
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1360 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1414
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1415 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2119
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE 2145
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1596
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1652
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1653 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1709
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1710 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1764 ---MEVLLASKARAE 1775
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1985 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2028
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2087 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2137 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2235
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 391 QLQQE 395
+++
Sbjct: 2296 LAEED 2300
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1694
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1041
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1222 WLQDARRRQEQIQ 1234
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2239 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2284
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2405 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2457
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2514
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2565
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1328 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1382
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1383 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1439
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1559
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2087
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQE 2113
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1564
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1620
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1621 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1677
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1678 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1731
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1732 ---MEVLLASKARAE 1743
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1953 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 1996
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2055 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2105 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2084
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2203
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263
Query: 391 QLQQE 395
+++
Sbjct: 2264 LAEED 2268
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1662
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRK 1868
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1078 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1193
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 951 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1009
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1010 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1069
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1190 WLQDARRRQEQIQ 1202
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2408 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2453
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2574 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2626
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2683
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2734
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1497 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1551
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1552 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1608
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1728
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2256
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQE 2282
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1733
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1789
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1790 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1846
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1847 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1900
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1901 ---MEVLLASKARAE 1912
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 2122 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2165
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2224 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2274 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2253
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2372
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432
Query: 391 QLQQE 395
+++
Sbjct: 2433 LAEED 2437
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1831
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRK 2037
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1247 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1362
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 1120 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1178
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1179 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1238
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1359 WLQDARRRQEQIQ 1371
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2249 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2294
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2415 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2467
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2524
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2575
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1338 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1392
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1393 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1449
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1569
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2097
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQE 2123
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1574
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1630
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1631 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1687
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1688 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1741
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1742 ---MEVLLASKARAE 1753
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1963 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2006
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2065 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2115 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2094
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2213
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273
Query: 391 QLQQE 395
+++
Sbjct: 2274 LAEED 2278
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1672
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRK 1878
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1088 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1203
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 961 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1019
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1020 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1079
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1200 WLQDARRRQEQIQ 1212
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2257 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2302
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2423 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2475
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2532
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2583
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1346 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1400
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1401 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1457
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1458 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1577
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1996
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2105
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQE 2131
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1582
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1638
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1639 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1695
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1696 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1749
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1750 ---MEVLLASKARAE 1761
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1971 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2014
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2073 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2123 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2102
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2221
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281
Query: 391 QLQQE 395
+++
Sbjct: 2282 LAEED 2286
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1680
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRK 1886
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1096 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1211
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1212 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 969 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1027
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1028 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1087
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1208 WLQDARRRQEQIQ 1220
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 65.9 bits (159), Expect = 7e-11
Identities = 79/351 (22%), Positives = 150/351 (42%), Gaps = 43/351 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
E QV + +A L+V E R L +E L + A + L EK+
Sbjct: 2298 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKML-------------KEKM 2343
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREKLL 193
V+ + K AE+ K + Q Q +R +QL EE++ E R++ L
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
+ L+ + + E+ + +++ EI + + E++++++T +
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE +
Sbjct: 2464 QRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2516
Query: 314 LLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKELL 369
L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQERQ 2573
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2624
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 202
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1387 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1441
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1442 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1498
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 308
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1499 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 309 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 356
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1618
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 410
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 151 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 204
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 205 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 261
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037
Query: 262 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 309
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
Query: 310 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 369
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2146
Query: 370 QLIEQAQKLTATQSHLENRKQQLQQE 395
EQAQ Q+ E +++ +QE
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQE 2172
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1623
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 276
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1679
Query: 277 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1680 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1736
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1737 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1790
Query: 396 QWYLESLIQARQRLQ 410
+E L+ ++ R +
Sbjct: 1791 ---MEVLLASKARAE 1802
Score = 42.4 bits (98), Expect = 8e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 2012 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2055
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2114 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 385
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2164 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 386 E---NRKQQLQQEQWYL--ESLIQARQRLQ 410
E ++K L +E L E+ ARQR Q
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2143
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 272 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 331
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2262
Query: 332 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 390
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 391 QLQQE 395
+++
Sbjct: 2323 LAEED 2327
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1721
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 264
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 265 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 314
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 315 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 368
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQ 394
Q ++ ++ +E R QL++
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRK 1927
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 168 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1137 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1252
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Score = 30.4 bits (67), Expect = 3.3
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 210
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1068
Query: 211 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1069 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1128
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 324
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 325 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 381 TQSHLENRKQQLQ 393
R++Q+Q
Sbjct: 1249 WLQDARRRQEQIQ 1261
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 63.9 bits (154), Expect = 3e-10
Identities = 61/273 (22%), Positives = 132/273 (48%), Gaps = 25/273 (9%)
Query: 137 SLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 196
S++ +F+K +++ + KE+ + + + ++A+ R+Q +EE + E++ ++
Sbjct: 514 SVMKSFIKRNTPLRMDPKEKER---QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR 570
Query: 197 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQK 255
E R L + E + E+ QK +I+ + +++ R AE+ + K A +
Sbjct: 571 EER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM 628
Query: 256 ENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL 315
E +++ K++ +A R + +E++E+ Q L ++ K+ + E K E A+ L E+R
Sbjct: 629 EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE--AKRLAEQREQ 686
Query: 316 EKQLSEPDRRLLGKRKRRELNMKAQALKLA------------AKRFIFEYSCGINRENQQ 363
E++ E + +++RRE + Q +LA A+R + E + + +Q
Sbjct: 687 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 746
Query: 364 FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 396
++EL + +K Q L R+ Q +QE+
Sbjct: 747 LQREL-----EEKKKKEEQQRLAERQLQEEQEK 774
Score = 56.2 bits (134), Expect = 6e-08
Identities = 79/326 (24%), Positives = 144/326 (44%), Gaps = 43/326 (13%)
Query: 106 LSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTD 165
+SEL + L+DE L + PR P + V+P + T + T + +++ T
Sbjct: 457 VSELDEEQHLEDEEL-----QPPRSKTPSSPCPASKVVRPLR-TFLHTVQRNQMLMTPTS 510
Query: 166 LNKHIKQAQTQRKQLLE-ESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYL 224
+ + ++ +R L + +E R++L E L K E + +KV
Sbjct: 511 APRSVMKSFIKRNTPLRMDPKEKERQRL----------ENLRRKEEAEQLRRQKVEEDKR 560
Query: 225 QKSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEI 283
++ E++ +R+E L+ L +E + Q ++K Q + A + EK EK
Sbjct: 561 RRLEEVKLKREER----------LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
Query: 284 QTLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE--- 334
+ E K + A K EV+A+ QE +RL Q E +RR LL K+K E
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQER 670
Query: 335 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 394
L A+A +LA +R E RE ++ ++E + + Q+ + L ++++ +Q
Sbjct: 671 LRKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRREQ 724
Query: 395 EQWYLESLIQARQRLQGSHNQCLNRQ 420
E+ E +Q R++ + L R+
Sbjct: 725 ERLQAERELQEREKALRLQKEQLQRE 750
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/256 (21%), Positives = 118/256 (46%), Gaps = 38/256 (14%)
Query: 143 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF- 201
++ +K+ + + R E++ + + + + QA+ + +Q+ EE ++ Q E +F
Sbjct: 550 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK--------QIEQKFAQ 601
Query: 202 LEYLTNKTEEYTEQPEKVWN-SYLQKSGEIE-RRRQESASRYAEQISVLKTALLQKENIQ 259
++ T K +E EK + +K E+E RR+QE +R + + +E +Q
Sbjct: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
Query: 260 SSLKRKLQAMRDIAILKE-----KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 314
+ + + +R A K +QE+ Q +E+ ++ Q + RE + QL +++R
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Query: 315 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ 374
E++ + + REL + +AL+L ++ + RE ++ KK+ E+
Sbjct: 722 REQERLQAE---------RELQEREKALRLQKEQ--------LQRELEEKKKK-----EE 759
Query: 375 AQKLTATQSHLENRKQ 390
Q+L Q E K+
Sbjct: 760 QQRLAERQLQEEQEKK 775
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 63.2 bits (152), Expect = 5e-10
Identities = 79/353 (22%), Positives = 155/353 (43%), Gaps = 46/353 (13%)
Query: 82 TLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDE-----CLDSRFAEGPRRLLPPYH 136
+L + EL+ Q+ A SL V S+ + +DLQ + L+ R E ++L
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL----- 774
Query: 137 SLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 196
+ EK TRL + +E + K Q + KQ+L++ E ++ +Q
Sbjct: 775 -------EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 197 ENRFFLEYLTNKTEEYTEQPEKV----------WNSYLQKSGEIERRRQESASRYAEQIS 246
E L N+ + + +KV ++ K ++ + S S + ++
Sbjct: 828 EE------LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 247 VLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 306
K A+L E LK +LQ + + K++KE++ E+ K+ + + +Q
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTL---KEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 307 QLLQEKRLLEKQLSEPDRRLLG-----KRKRRELNMKAQALKLAAKRFIFEYSCGINREN 361
QL+Q + L KQ + +++L G K+ + + +AL+ K + + + N+
Sbjct: 939 QLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 362 QQFKKELLQLIEQAQKLTATQSHLENRKQ---QLQQEQWYLES-LIQARQRLQ 410
QQ + +L + +K++ Q++ E ++ QLQ + + ES L+ RQ L+
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/307 (21%), Positives = 135/307 (43%), Gaps = 35/307 (11%)
Query: 144 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 203
K ++L K+ T+L +++ A++ D +H Q ++ K+ E+ L ++ E
Sbjct: 679 KQQELNKITTQL-DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT-----------E 726
Query: 204 YLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS-- 261
L + ++ +V S Q +++++RQ + + K ++KE + S+
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 262 -LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS 320
L++K +A+ I KQE+E Q L+++ + + ET + E+ ++ L+K
Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 321 EPDRRLLG-KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 379
E + + + +L+ + +LK + F +ENQ+ K +L L + ++L
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEF--------EKENQKGKAAILDLEKTCKELK 898
Query: 380 -ATQSHLENR-------KQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQ 431
Q +EN K+ L++E+ E+ Q + L Q + Q+ K Q
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEK---EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 432 GTKSRIN 438
+ IN
Sbjct: 956 QLQGNIN 962
Score = 50.1 bits (118), Expect = 4e-06
Identities = 68/288 (23%), Positives = 129/288 (44%), Gaps = 27/288 (9%)
Query: 154 RLKEKIVAEMTDLNK-HIKQAQTQR--KQLLEESRELHREKLLVQAENRFFLEYLTNKTE 210
+L+ ++ A T L++ H++ ++ ++L EE E+ + ++AE + L+ + E
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ-LQQQREEKE 406
Query: 211 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 270
++ Q + N K E ER+ E+ R EQ + L+ KE + L+ KL +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 271 DIAILKEKQEKEIQTLQEETKK-------VQAETASKTREVQAQLLQEKRLLEKQLSEPD 323
+ K E+Q ++TK+ +Q T +K RE Q L Q R Q+ + D
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR----QIGDKD 522
Query: 324 RR------LLGKRKRRELNMKAQALKLAAKRFIFEYSCGI----NRENQQFKKELLQLIE 373
++ LL K K ++ + L AK E + +N ++++ QL E
Sbjct: 523 QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582
Query: 374 QAQKLTATQSHL-ENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+ + + + EN Q+Q+++ +L + L+ S N+ LN Q
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE-LNSQ 629
Score = 44.3 bits (103), Expect = 2e-04
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 41/291 (14%)
Query: 156 KEKIVAEMTDLNKHIKQAQTQRKQLLEES----RELHREKLLVQAENRFFLEYLTNKTEE 211
+ K++ E+ ++Q +++Q L+E +++ +EK L + E L N+ +
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE-------LVNEKSK 1125
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
E E ++ EI + +E S E I + T L + + K +LQ D
Sbjct: 1126 LAEIEE----IKCRQEKEITKLNEELKSHKLESIKEI-TNLKDAKQLLIQQKLELQGKAD 1180
Query: 272 -IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL---LQEKRLLEKQLSEPDRRL- 326
+ E++++ Q L+++ KK + E + E +A+L ++EK + K+ E + +L
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 327 ---------LGKRK-------RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQ 370
LG K RR ++ Q L + + E + + NQ ++ LL+
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV---QNNQDERRALLE 1297
Query: 371 LIEQAQ-KLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
+ + ++ Q+ + +++L ++ L + Q LQ H Q LNR+
Sbjct: 1298 RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348
Score = 43.9 bits (102), Expect = 3e-04
Identities = 64/295 (21%), Positives = 128/295 (43%), Gaps = 34/295 (11%)
Query: 147 KLTKVETRLKEKIVAE---MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 203
KL + T+ +++ AE ++ L + +++Q KQL + E L + + + E
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 204 YLTNKTEEYTEQPEKVWNS--YLQKSGEIERRRQESASRYAEQISVLKTAL--LQKENI- 258
L+ E+ ++ N +Q+ + ++ +++ +Q+ AL +QKE
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 259 -QSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAET---ASKTREVQAQLLQEKRL 314
+ L + + +I +K +QEKEI L EE K + E+ + ++ + L+Q+K
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 315 LE------KQLSEPDRR----LLGKRKRRELNMKAQALKLAAKRF--IFEYSCGINRENQ 362
L+ K E ++R L + K+ E +K + ++ AK I E G+ + +
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 363 QFKKELLQLIEQAQKLTATQ----------SHLENRKQQLQQEQWYLESLIQARQ 407
K +Q+ + L + S LE + L+ E LE+ +Q Q
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
Score = 43.5 bits (101), Expect = 4e-04
Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 28/205 (13%)
Query: 113 RDLQDECLDSR-FAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIK 171
+DLQ + + ++E ++ L Y L KP+ L + AE+ L + ++
Sbjct: 93 QDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS-------AELQSLEQQLE 145
Query: 172 QAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 231
+AQT+ + ++ ++L +K A + + +Y E+ S + + +
Sbjct: 146 EAQTENFNI-KQMKDLFEQKAAQLATE------IADIKSKYDEE-----RSLREAAEQKV 193
Query: 232 RRRQESASRYAEQISVLKTALLQKENIQ--SSLKRKL---QAMRDIAILKEKQEKEIQTL 286
R E ++ A I LKT LLQ+ I+ + LK++L Q + D L+ +E+E + L
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE--RERESEKL 251
Query: 287 QEETKKVQAETASKTREVQAQLLQE 311
++E KK+Q++ AS + +QL E
Sbjct: 252 KDECKKLQSQYASSEATI-SQLRSE 275
Score = 35.0 bits (79), Expect = 0.14
Identities = 58/277 (20%), Positives = 111/277 (40%), Gaps = 33/277 (11%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYL 205
+KL+KV LK ++ K ++ + L + +EL + +L VQ EN
Sbjct: 860 DKLSKVSDSLKNS----KSEFEKENQKGKAAILDLEKTCKEL-KHQLQVQMEN------- 907
Query: 206 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 265
T + +K L+K E + + + EQ+ + L Q E + L+
Sbjct: 908 -------TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 266 LQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS----- 320
+ ++ + K+KQ + +Q + + E +K ++ Q QE ++++S
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 321 -----EPDRRLLGKRKRRELNMKA--QALKLAAKRFIFEYSCGINRENQQFKKELLQLIE 373
E ++L RE + A Q LK ++ I+ NQ + +LI+
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN--KLIQ 1078
Query: 374 QAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 410
+ + AT +K+Q QE+ IQ + L+
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 61.6 bits (148), Expect = 1e-09
Identities = 62/275 (22%), Positives = 132/275 (48%), Gaps = 25/275 (9%)
Query: 137 SLINNFVKPEKLTKVETRLK--EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLV 194
S++ +F+K +++ + EK + +L + ++A+ R+Q +EE + E++ +
Sbjct: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKL 572
Query: 195 QAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALL 253
+ E R L + E + E+ QK +I+ + +++ R AE+ + K A
Sbjct: 573 KREER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 630
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
+ E +++ K++ +A R + +E++E+ Q L ++ K+ + E K E A+ L E+R
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE--AKRLAEQR 688
Query: 314 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLA------------AKRFIFEYSCGINREN 361
E++ E + +++RRE + Q +LA A+R + E + +
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 748
Query: 362 QQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 396
+Q ++EL + +K Q L R+ Q +QE+
Sbjct: 749 EQLQREL-----EEKKKKEEQQRLAERQLQEEQEK 778
Score = 55.1 bits (131), Expect = 1e-07
Identities = 79/325 (24%), Positives = 141/325 (43%), Gaps = 37/325 (11%)
Query: 106 LSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTD 165
+SEL + L+DE L + PR P + V+P + T + T + +++ T
Sbjct: 457 VSELDEEQHLEDEEL-----QPPRSKTPSSPCPASKVVRPLR-TFLHTVQRNQMLMTPTS 510
Query: 166 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+ + ++ +R L K + R LE L K E + +KV +
Sbjct: 511 APRSVMKSFIKRNTPLRMD-----PKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRR 565
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEIQ 284
+ E++ +R+E L+ L +E + Q ++K Q + A + EK EK +
Sbjct: 566 RLEEVKLKREER----------LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Query: 285 TLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE---L 335
E K + A K EV+A+ QE +RL Q E +RR LL K+K E L
Sbjct: 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 675
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
A+A +LA +R E RE ++ ++E + + Q+ + L ++++ +QE
Sbjct: 676 RKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRREQE 729
Query: 396 QWYLESLIQARQRLQGSHNQCLNRQ 420
+ E +Q R++ + L R+
Sbjct: 730 RLQAERELQEREKALRLQKEQLQRE 754
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/256 (21%), Positives = 118/256 (46%), Gaps = 38/256 (14%)
Query: 143 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF- 201
++ +K+ + + R E++ + + + + QA+ + +Q+ EE ++ Q E +F
Sbjct: 554 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK--------QIEQKFAQ 605
Query: 202 LEYLTNKTEEYTEQPEKVWN-SYLQKSGEIE-RRRQESASRYAEQISVLKTALLQKENIQ 259
++ T K +E EK + +K E+E RR+QE +R + + +E +Q
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 665
Query: 260 SSLKRKLQAMRDIAILKE-----KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 314
+ + + +R A K +QE+ Q +E+ ++ Q + RE + QL +++R
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Query: 315 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ 374
E++ + + REL + +AL+L ++ + RE ++ KK+ E+
Sbjct: 726 REQERLQAE---------RELQEREKALRLQKEQ--------LQRELEEKKKK-----EE 763
Query: 375 AQKLTATQSHLENRKQ 390
Q+L Q E K+
Sbjct: 764 QQRLAERQLQEEQEKK 779
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 59.3 bits (142), Expect = 7e-09
Identities = 67/272 (24%), Positives = 130/272 (47%), Gaps = 32/272 (11%)
Query: 171 KQAQTQRKQLLEESRELHREKLL--VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSG 228
++ Q +R+Q L ++L RE+ L Q E R ++ + E+ ++ ++ +L++
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 229 EIER----RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 284
E ER RR++ R E+ + L++E + +R+ Q +R +E++E+ Q
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-----REQEERREQ 517
Query: 285 TL--QEETKKVQAETASKTR------EVQAQLL---QEKRLLEKQLSEPDRRLLGKRKRR 333
L QEE +++Q S+ + E + QLL +EKRL +++ + +R +R+ +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 334 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA----QKLTATQSHLENRK 389
L + + + KR E R Q+ K+E ++ +EQ Q+L + E R+
Sbjct: 578 LLKREEERRQQRLKREQEE------RLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 390 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 421
Q L+ E+ Q R+ Q Q L R++
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Score = 58.2 bits (139), Expect = 1e-08
Identities = 70/251 (27%), Positives = 117/251 (46%), Gaps = 28/251 (11%)
Query: 172 QAQTQRKQLLEESRELHREKLLVQAE--NRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 229
+ Q +R++LLE R+ EK + E +R F E + E+ + E V +K E
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQE----EEEKEWRKRETVLRKEEEKLQE 262
Query: 230 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 289
E +RQ EQ+ L+ L++E + +++ Q +R L+ KQE+E + QEE
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 290 TKKVQ--AETASKTREVQAQLLQEKRLLEKQL---SEPDRRLLGKRKRRELNMKAQALKL 344
++ Q E + RE Q + QE+R E+QL E +RR R+ +E + Q L+
Sbjct: 321 RREQQERREQQEERREQQLRREQEER-REQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 345 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 404
+ R QQ ++E Q + + Q+L Q R+QQL++EQ
Sbjct: 380 EQQL----------RREQQLRRE--QQLRREQQLRREQQ--LRREQQLRREQQLRREQQL 425
Query: 405 ARQRLQGSHNQ 415
R++ + H Q
Sbjct: 426 RREQEEERHEQ 436
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/274 (25%), Positives = 129/274 (47%), Gaps = 28/274 (10%)
Query: 171 KQAQTQRKQL-----LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
+++Q QR+ LEE R+ R L + + E L + + E+ E+ LQ
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ---EQLRKEQQLLQEEEEE-----LQ 914
Query: 226 KSGEIERRRQESASRYAE--QISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 283
+ +RRRQE +Y E Q+ + LL++E + +R+ + R K+ Q+KE
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREK---RRRQERERQYRKDKKLQQKEE 971
Query: 284 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK---RKRRELNMKAQ 340
Q L EE +K + + K + +L QE+ L ++ E RR + RK+ EL + +
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031
Query: 341 AL--KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE---NRKQQLQQE 395
L + KR + E RE ++ ++E QL+ + ++ T + LE ++++LQQE
Sbjct: 1032 QLLREEREKRRLQERERQY-REEEELQQEEEQLLGE-ERETRRRQELERQYRKEEELQQE 1089
Query: 396 QWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSL 429
+ L ++R Q QC +++ + L
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/251 (21%), Positives = 114/251 (45%), Gaps = 12/251 (4%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQ----LLEESRELHREKLLVQAENRFFLEYLTN 207
E +L+ + + E+ + KQ Q + +Q EE +E + + +++ E E
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 208 KTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 267
+ E E+ E++ Q+ ER+ +E + + L+ ++ Q +R+ Q
Sbjct: 267 RQRELQEEEEQLRKLERQELRR-ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 268 AMRDIAILKEKQEKEIQTLQEETKKVQA--ETASKTREVQAQLLQEKRLLEKQLSEPDRR 325
R+ +E++E++++ QEE ++ Q E + RE Q + QE+ E+QL +
Sbjct: 326 ERREQQ--EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 326 LLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHL 385
++ RRE ++ + ++ E R QQ ++E EQ ++ +
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 386 ENRKQQLQQEQ 396
E R+Q+L++EQ
Sbjct: 441 ERREQRLKREQ 451
Score = 53.9 bits (128), Expect = 3e-07
Identities = 60/266 (22%), Positives = 117/266 (43%), Gaps = 44/266 (16%)
Query: 171 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 230
+ Q +RKQ L+ +E R + ++ E E + ++ + E+ L++ E
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 231 ERRRQ----------ESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQE 280
ER +Q E R + + + L++E + LKR+ + RD +LK ++E
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD-QLLKREEE 584
Query: 281 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 340
+ Q L+ E ++ + E K EV+ +E+R + EP+ +RR+ +K++
Sbjct: 585 RRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKREEPE------EERRQQLLKSE 637
Query: 341 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKL---TATQSHLENRKQQLQQE-- 395
+ ++ + RE Q+ +++ L+ E+ ++L + E R+Q+L +E
Sbjct: 638 EQEERRQQ-------QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 396 --------------QWYLESLIQARQ 407
QW LES ARQ
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQ 716
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/282 (21%), Positives = 132/282 (46%), Gaps = 34/282 (12%)
Query: 171 KQAQTQRKQLLEESRELHREKLLVQAENRFFLE-----YLTNKTEEYTEQPEKVWNSYLQ 225
+Q + QR EE +E R + + + FLE + ++ E+ + + +
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 285
+ + +RR Q+ + E+ + L K +Q L+++ Q +++ +++E+E +
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 286 LQEETKKVQAETASKTREVQAQLLQEKR------------LLEKQLSEPDRRLLG----K 329
QE+ ++ + E + ++ + QLL+E+R +K+L + + +LLG K
Sbjct: 923 RQEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 330 RKRRELNMK---AQALKLAAKRFIFEYSCGINRE--NQQFKK--ELLQLIEQAQKLTATQ 382
R+R+E K + L+ ++ + E R+ +Q++K EL Q EQ + +
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 383 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPK 424
L+ R++Q ++E E L Q ++L G + RQ++ +
Sbjct: 1041 RRLQERERQYREE----EELQQEEEQLLGEERETRRRQELER 1078
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/302 (19%), Positives = 138/302 (45%), Gaps = 33/302 (10%)
Query: 136 HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQ 195
H+L E+L K + L+E+ + +++ + ++++ E+ R+ E+ L Q
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEE--------EEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 196 AENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI------ERRRQESASRYAEQISVLK 249
E + E + + E+ + QK ++ +RRRQE +Y E+
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE--- 995
Query: 250 TALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLL 309
LQ+E Q + + + R + +++ E+Q QEE + ++ E + + + +
Sbjct: 996 ---LQQEEEQLLREEREKRRRQEWERQYRKKDELQ--QEEEQLLREEREKRRLQERERQY 1050
Query: 310 QEKRLLEKQLSEPDRRLLGK----RKRRELN---MKAQALKLAAKRFIFEYSCGINRENQ 362
+E E++L + + +LLG+ R+R+EL K + L+ ++ + E R+ +
Sbjct: 1051 RE----EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 363 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDV 422
+ + + ++Q ++ + + R+Q+L+++ E + Q ++L + RQ++
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Query: 423 PK 424
+
Sbjct: 1167 ER 1168
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/282 (23%), Positives = 119/282 (42%), Gaps = 40/282 (14%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF---- 201
EK + E + + E+ + + + + ++++L E R+ E+ L Q E +
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 202 -------LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQ 254
LE K EE ++ E++ +K ER RQ R E++ + LL+
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ---CREEEELQQEEEQLLR 1125
Query: 255 KENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 314
+E + +R+ + R +E Q++E Q L+EE +K + + + + +L QE+
Sbjct: 1126 EEREK---RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 315 L------------EKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIFEYS 354
L E+Q E + KRK+R +L + + K A R Y
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 355 CGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 396
G REN+QF++ + Q Q HL +Q+ +EQ
Sbjct: 1243 KG--RENEQFRQLEDSQLRDRQSQQDLQ-HLLGEQQERDREQ 1281
Score = 50.1 bits (118), Expect = 4e-06
Identities = 59/260 (22%), Positives = 118/260 (45%), Gaps = 10/260 (3%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYL 205
E+ ++ R +EK + + + ++ + +R QLL+ E +++L + E R + L
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE-QRL 602
Query: 206 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 265
+ E EQ E+ ++ E ERR+Q S E+ + Q+E + LKR+
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 266 LQAMRDIAILK---EKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEP 322
+ R LK E++ +E + +EE ++ + S+ + Q QL E + ++
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 323 DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ------AQ 376
R+ G+R+R+E K + + + E + +E +Q + Q + Q
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 377 KLTATQSHLENRKQQLQQEQ 396
+L+A E R++QL+ E+
Sbjct: 783 RLSARPPLREQRERQLRAEE 802
Score = 48.9 bits (115), Expect = 9e-06
Identities = 49/278 (17%), Positives = 125/278 (44%), Gaps = 15/278 (5%)
Query: 143 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFL 202
++ E+ + E +L+ + E + +Q + +R+Q L ++L RE+ L + E +
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL-RREQQLRR 397
Query: 203 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 262
E + ++ + + L++ ++ R ++E ++E + L
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH----------EQERREQRL 447
Query: 263 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEP 322
KR+ + RD LK ++E E + ++++ + + RE +L +E+R +++ E
Sbjct: 448 KREQEERRD--WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 323 DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 382
R + +R + + + + +R E + RE ++ +++LL+ E+ + +
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LRREQEERREQLLKREEEKRLEQERR 563
Query: 383 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 420
R+Q+ +++Q + +QRL+ + L ++
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Score = 48.9 bits (115), Expect = 9e-06
Identities = 61/267 (22%), Positives = 119/267 (44%), Gaps = 27/267 (10%)
Query: 162 EMTDLNKHIKQAQTQRKQLLEESRELHRE--KLLVQAENRFFLEYLTNKTEEYTEQPEKV 219
++ D +Q+Q + LL E +E RE + Q +R F E + EE E +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 220 WNSY-----LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 274
S L++ E +RRRQE+ ++ E+ +L+ +R+ Q +R
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ-------------EREEQPLRRQER 1358
Query: 275 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 334
++ +E+E++ ++ K ++ E + +E + + L+E++ L Q E +++L R R+
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ--EREQQLRQDRDRKF 1416
Query: 335 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 394
+ Q + R E + R+ ++ K +E+ Q+L + ++QL Q
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERK-----FLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 395 EQWYLESLIQARQRLQGSHNQCLNRQD 421
E+ + Q R R Q L RQ+
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQE 1498
Score = 48.5 bits (114), Expect = 1e-05
Identities = 70/316 (22%), Positives = 139/316 (43%), Gaps = 25/316 (7%)
Query: 121 DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL 180
D +F E + L + + K + E R +E+ + + + +++ + +RK L
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ-GRKFLEEEQRLRRQERERKFL 1393
Query: 181 LEES--RELHREKLLVQAENRFFLEY-----LTNKTEEYTEQPEKVWNSYLQKS--GEIE 231
EE R RE+ L Q +R F E + ++ E+ ++V ++ E +
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 232 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKL---QAMRDIAILKEKQEKEIQTLQE 288
+ RQE ++ E+ +L+ Q+ + Q ++ L Q +R ++ +E+E+++ +
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Query: 289 ETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE---LNMKAQALKLA 345
E K ++ E ++ Q + LQE++ L +Q RR RK RE L + + +L+
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 346 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQA 405
+ E E Q+ +++ EQ +K + L ++ Q Q Q +
Sbjct: 1574 RQ----ERDRKFRLEEQKVRRQ-----EQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 406 RQRLQGSHNQCLNRQD 421
Q LQ Q L+RQ+
Sbjct: 1625 EQLLQEREEQQLHRQE 1640
Score = 48.1 bits (113), Expect = 2e-05
Identities = 54/254 (21%), Positives = 114/254 (44%), Gaps = 42/254 (16%)
Query: 171 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 230
++ Q Q ++L E + +++ L Q + + E L + +E+ E+ E+ + ++
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER-----RAEEEQL 193
Query: 231 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ----TL 286
+ + + ++ + + LL+ K++ + R + +E++EKE + L
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 287 QEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 346
++E +K+Q E + RE+Q + E+QL + +R+ L +R+R+E + Q L+
Sbjct: 254 RKEEEKLQEEEPQRQRELQEE--------EEQLRKLERQEL-RRERQEEEQQQQRLR--- 301
Query: 347 KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQAR 406
RE Q +K+ + EQ + E R+QQ ++EQ Q R
Sbjct: 302 ------------REQQLRRKQEEERREQQE---------ERREQQERREQQEERREQQLR 340
Query: 407 QRLQGSHNQCLNRQ 420
+ + Q L R+
Sbjct: 341 REQEERREQQLRRE 354
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/249 (22%), Positives = 106/249 (42%), Gaps = 45/249 (18%)
Query: 171 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 230
KQ +R+Q EE R +L Q E R + +E ++ + W ++ E
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAH-----RQQQEEEQRRDFTWQWQAEEKSER 779
Query: 231 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 290
R+R + EQ +R+L+A +E+Q++E + L EE
Sbjct: 780 GRQRLSARPPLREQ-----------------RERQLRA-------EERQQREQRFLPEEE 815
Query: 291 KKVQAETASKTREVQAQLLQEKRLLEKQ------------LSEPDRRLLGKRKRRELNMK 338
+K Q + RE + Q L+E+ L+++ L E R + +RR+ +
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 339 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWY 398
Q + +R Y+ +E + +++LLQ E+ ++L + E R++Q Q+ Q+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ--EEEEEL--QREEREKRRRQEQERQYR 931
Query: 399 LESLIQARQ 407
E +Q +
Sbjct: 932 EEEQLQQEE 940
Score = 47.8 bits (112), Expect = 2e-05
Identities = 63/260 (24%), Positives = 115/260 (44%), Gaps = 35/260 (13%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E +L+ K E + + ++ Q +R E+ E ++L + E R + + EE
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERR----EQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 212 YTEQPEKVWNSYLQKSGEIERR----RQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 267
EQ L++ E ERR R+E R +Q+ + L++E L+R+ Q
Sbjct: 359 RREQ-------QLRREQEEERREQQLRREQQLRREQQLR--REQQLRRE---QQLRREQQ 406
Query: 268 AMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE--------KRLLEKQL 319
R+ + +E+Q + Q L+ E ++ + E + + +L +E KR E +
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 320 SEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 379
E +RR ++ +E + + LKL + E R QQ ++E + EQ K
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEE----ERREQQERREQQLRREQEERREQRLKRQ 522
Query: 380 ATQSHLENR---KQQLQQEQ 396
+ L+ R +QQL++EQ
Sbjct: 523 EEEERLQQRLRSEQQLRREQ 542
Score = 47.4 bits (111), Expect = 3e-05
Identities = 66/310 (21%), Positives = 134/310 (43%), Gaps = 35/310 (11%)
Query: 121 DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL 180
+ +F E ++L H F + E+L ++ R ++++ + D K +++ Q R+Q
Sbjct: 1445 ERKFLEEEQQLRQERH---RKFREEEQL--LQEREEQQLHRQERD-RKFLEEEQQLRRQ- 1497
Query: 181 LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR 240
E R+ ++L Q R FLE EE ++ +LQ+ ++ R+ + R
Sbjct: 1498 -ERDRKFREQELRSQEPERKFLE------EEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 241 YAEQISVLKTALLQKENIQSSLKRKLQ----AMRDIAILKEKQEKEIQT------LQEET 290
+ L++E + L R+ + + + + +++QE++ QE
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610
Query: 291 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 350
++++ E K RE + QLLQE+ + E DR+ L + + + Q L+ R
Sbjct: 1611 QQLRQERDRKFREDE-QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 351 FEYSCGINRENQQ----------FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 400
E + +Q F++E QL Q ++ Q + R+Q+L+++ E
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 401 SLIQARQRLQ 410
L Q ++ Q
Sbjct: 1730 QLRQETEQEQ 1739
Score = 45.8 bits (107), Expect = 8e-05
Identities = 52/254 (20%), Positives = 115/254 (45%), Gaps = 22/254 (8%)
Query: 171 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 230
+Q + + +QL E E RE+ L + + E + ++ + + L++ ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 231 ERRRQ---ESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQ 287
R +Q E R +Q+ + L++E + ++K + R LK +QE+ L+
Sbjct: 402 RREQQLRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 288 EETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK 347
E + + E + ++++ +E+R +L E +RR +++RRE ++ + + +
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE--QQERREQQLRREQEERREQ 517
Query: 348 RFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 407
R + Q+ ++ L Q + Q+L Q E R+Q L++E+ E ++ +
Sbjct: 518 RL----------KRQEEEERLQQRLRSEQQLRREQE--ERREQLLKREE---EKRLEQER 562
Query: 408 RLQGSHNQCLNRQD 421
R Q + R+D
Sbjct: 563 REQRLKREQEERRD 576
Score = 41.6 bits (96), Expect = 0.001
Identities = 66/312 (21%), Positives = 134/312 (42%), Gaps = 49/312 (15%)
Query: 121 DSRFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQ-TQRKQ 179
D +F E + L ++ + K + E +L+ + E +H + + + +Q
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ---EREQQLRHDRDRKFREEEQ 1674
Query: 180 LLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS 239
LL+E E ++L Q +R F E EE + ++ +LQ+ ++ R+ E
Sbjct: 1675 LLQEGEE---QQLRRQERDRKFRE------EEQQLRRQERERKFLQEEQQLRRQELERKF 1725
Query: 240 RYAEQI----------------SVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 283
R EQ+ +L+ L+ E + L+R+ RD K ++E+++
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ---ERD---RKFREEEQL 1779
Query: 284 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALK 343
+ +EE + E+ K RE + QL QE+ E+QL R + + +L ++ Q +
Sbjct: 1780 RQEREEQQLRSQESDRKFRE-EEQLRQERE--EQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 344 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLI 403
L + R+ Q +E E++++ E +K++ ++E+ E I
Sbjct: 1837 LRQE-----------RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 404 QARQRLQGSHNQ 415
+ +Q+ + H Q
Sbjct: 1886 RRQQKEEQRHRQ 1897
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 59.3 bits (142), Expect = 7e-09
Identities = 60/257 (23%), Positives = 116/257 (45%), Gaps = 28/257 (10%)
Query: 155 LKEKIVAEMTDLNKHIKQAQTQRKQLLEESREL-HREKLLVQAENRFFLEYLTNKTEEYT 213
L+ + AE + +T + QL E+++EL H + L A+ L K ++++
Sbjct: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE--LAAFRTKVQDHS 1203
Query: 214 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 273
+ ++ W + + + + R+ S E++S+L +L+KE LKR + A +
Sbjct: 1204 KAEDE-WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE-- 1260
Query: 274 ILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRR 333
+K E+ ++ LQ ET A A ++ ++ ++ + EKQ R+ + R+
Sbjct: 1261 -KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ------RVASENLRQ 1313
Query: 334 ELNMKA-------QALKLAAKRFIFEYSCGI------NRENQQFKKELLQLIEQAQKLTA 380
EL +A Q LK ++F F+ + + Q ELL Q+L A
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKF-FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
Query: 381 TQSHLENR-KQQLQQEQ 396
Q+ E R +++L+Q +
Sbjct: 1373 EQAAAEKRHREELEQSK 1389
Score = 50.8 bits (120), Expect = 2e-06
Identities = 56/253 (22%), Positives = 109/253 (43%), Gaps = 28/253 (11%)
Query: 156 KEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQ 215
K+++ + +TDL I +Q K+ LE++ + H +L Q + + T E T
Sbjct: 461 KQQLSSLITDLQSSISNL-SQAKEELEQASQAHGARLTAQ---------VASLTSELTTL 510
Query: 216 PEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAIL 275
+ Q+ E+ +Q++ + A+ L L Q+E L+ +++ +
Sbjct: 511 NATIQ----QQDQELAGLKQQAKEKQAQ----LAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 276 KEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 335
KE+Q KE+ QE T++ A+ + E + L+E+ KQL L K K +L
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL-----EALEKEKAAKL 617
Query: 336 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ Q L++A E Q ++E +L + ++L A + + Q +
Sbjct: 618 EILQQQLQVAN-----EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 396 QWYLESLIQARQR 408
LE +++ Q+
Sbjct: 673 VAELELQLRSEQQ 685
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/289 (24%), Positives = 129/289 (44%), Gaps = 28/289 (9%)
Query: 143 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF- 201
++P++L ++ + E + + + K + +T++ Q+ + +L E + + R F
Sbjct: 273 LEPKELEELRDK-NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 202 --LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQ 259
L+ L + E TE+ K +L+K ++E ++ SA+ ++ K +LQ +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGK--L 387
Query: 260 SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAET-ASKTREVQAQLLQEKRLLEKQ 318
S L+ L ++D +EK E LQ ET K +A T A+ ++QA++ +LE +
Sbjct: 388 SQLEEHLSQLQDNP-PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV----EMLETE 442
Query: 319 LSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQ-- 376
+ + +LL +R E K I + I+ +Q KE L+ QA
Sbjct: 443 RGQQEAKLLAERGHFEEE------KQQLSSLITDLQSSISNLSQ--AKEELEQASQAHGA 494
Query: 377 KLTA----TQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 421
+LTA S L +QQ+ L L Q + Q Q L +Q+
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Score = 45.8 bits (107), Expect = 8e-05
Identities = 57/212 (26%), Positives = 93/212 (43%), Gaps = 34/212 (16%)
Query: 152 ETRLKE-KIVAEMTDLNKHIKQAQTQ--RKQLLEESRELH--REKLLVQAEN-RFFLEYL 205
ETRL E + A+ T + A+ + + ++LEE + R+KL Q E F
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 206 TNKTEEYT------EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQ 259
T + EE + +Q KV L+ Q+ A R Q++ L+ L QKE
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Query: 260 SSLKRKLQAMRDIAILKEKQEKEIQ-------TLQEETKKVQAETASKTREVQAQLLQEK 312
K +++ + K++Q +E+Q LQ+E K+++AE E+Q L+ K
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTK 1667
Query: 313 -------------RLLEKQLSEPDRRL--LGK 329
R LE Q++ D++L LGK
Sbjct: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 39.7 bits (91), Expect = 0.005
Identities = 54/279 (19%), Positives = 115/279 (41%), Gaps = 22/279 (7%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQL---LEESRELHREKLLVQAENRFFLEYLT 206
K ETR +V + K +++ + RK L L++ E H+ + V
Sbjct: 740 KAETR---SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 207 NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKL 266
+ E EQ K ++ ++ + ++ + + + EQ+ LK E + + +
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK------EECEKARQELQ 850
Query: 267 QAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL 326
+A +A ++ E +I Q E ++ A A ++VQ + ++ ++L + LS ++
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEKM 909
Query: 327 LGKRKR----RELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 382
K L KA + A R + + ++ +E +Q ++ +TQ
Sbjct: 910 AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEE-----QQGRQFCSTQ 964
Query: 383 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 421
+ L+ +++ +Q LE L A QG + +Q+
Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE 1003
Score = 38.9 bits (89), Expect = 0.009
Identities = 75/351 (21%), Positives = 143/351 (40%), Gaps = 35/351 (9%)
Query: 76 KLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPY 135
K E +A +LQ Q+ A SL VT L + + L+ + L
Sbjct: 686 KATEKERVAQEKDQLQEQL-QALKESLKVTKGSLEEEKRRAADALEEQ-QRCISELKAET 743
Query: 136 HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNK-HIKQAQTQRKQLLEESRELHREKLLV 194
SL+ + K + E ++ + A + L + H + + R++L E H
Sbjct: 744 RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT----A 799
Query: 195 QAENRFFLEYLTNKTEEY--TEQPEKVWNSYLQKS-----GEIERRRQE---SASRYA-- 242
++E ++ + E Y ++Q E + + Q+ E E+ RQE + + A
Sbjct: 800 ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGI 859
Query: 243 EQISVLKTALLQKE--NIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK 300
E S L+ + Q E + ++L R LQ +++ + +K ++ TLQE+ E A
Sbjct: 860 ESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL 919
Query: 301 TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRE 360
V+ Q++ + + EP R G R+ L + ++F C
Sbjct: 920 ETLVRKAGEQQETASRELVKEPAR--AGDRQPEWLE------EQQGRQF-----CSTQAA 966
Query: 361 NQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ-QEQWYLESLIQARQRLQ 410
Q ++E Q+ + ++L A + ++Q+ + Q++ + L Q R R Q
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
Score = 37.7 bits (86), Expect = 0.021
Identities = 48/275 (17%), Positives = 120/275 (43%), Gaps = 11/275 (4%)
Query: 163 MTDLNKHIKQAQTQRKQLLEESRELHREKLL-----VQAENRFFLEYLTNKTEEYTEQPE 217
+ + N+ + + +Q LE + REK + V+A+ L + + + + E
Sbjct: 1447 LAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELE 1506
Query: 218 KVWNSYLQKSGEI--ERRR-QESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 274
+ Y ++ ER+R QE + Q+ L+ ++ L +KL +
Sbjct: 1507 VMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASK 1566
Query: 275 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 334
+++++ K +Q E+++ ++ E+QAQL Q+++ E + ++ +++
Sbjct: 1567 VQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 335 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 394
N + Q +L + + + + + E ++ EL Q + ++ T HL + + L+
Sbjct: 1627 QNQELQE-QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 395 EQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSL 429
+ + + ++ + Q + + +R+ P+ P L
Sbjct: 1686 QVAHADQQLRDLGKFQVATDALKSRE--PQAKPQL 1718
Score = 37.4 bits (85), Expect = 0.027
Identities = 53/288 (18%), Positives = 126/288 (43%), Gaps = 48/288 (16%)
Query: 159 IVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEK 218
+ +E+T LN I+Q + L ++++E QA+ L+ ++ Q E+
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEK-------QAQLAQTLQQQEQASQGLRHQVEQ 555
Query: 219 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 278
+ +S QK +++ ++ + + L TA ++E +SL+ + A++ + L+++
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE---ASLRERDAALKQLEALEKE 612
Query: 279 QEKEIQTLQEETK--------------KVQAETASKTREV-----------------QAQ 307
+ +++ LQ++ + + Q E A +R+V QAQ
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 308 LLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKE 367
+ + + L + + + +++ +L + QALK + K + G E ++ +
Sbjct: 673 VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK-----VTKGSLEEEKRRAAD 727
Query: 368 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 415
L+ EQ + ++ ++ + +Q ++E+ LE R+ L+ Q
Sbjct: 728 ALE--EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Score = 33.9 bits (76), Expect = 0.30
Identities = 56/293 (19%), Positives = 125/293 (42%), Gaps = 36/293 (12%)
Query: 146 EKLTKVETRLKEKIVA---EMTDLNKHIKQAQTQ------RKQLLEESRELHREKLLVQA 196
EK+ +E+ + +I E+ +L+ ++ +A Q R Q L + +EK+ +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATS 913
Query: 197 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERR--RQESASRYAEQISVLKTALLQ 254
+ LE L K E E + ++G+ + ++ ++ + L+ +
Sbjct: 914 KEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMERE 973
Query: 255 KENIQSSLKRKLQAMRDIAILKEK----QEKEIQTLQEETKKVQAETA---SKTREVQAQ 307
E + + L+R A+ + +++ QE+E+ L +E + QA+ A + E++ +
Sbjct: 974 AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR 1033
Query: 308 L---LQEKRLLEKQLSEPDRRLLGKRKRRELNM-KAQALKLAAKRFIFEYSCGINRENQQ 363
L L E+R+ L E L +++ ++ + K + L+ A + + E + + +Q
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 364 FKKELLQLIE--------------QAQKLTATQSHLENRKQQLQQEQWYLESL 402
K+ + KL A ++ + +QQ Q++Q +SL
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Score = 31.2 bits (69), Expect = 2.0
Identities = 59/269 (21%), Positives = 104/269 (38%), Gaps = 40/269 (14%)
Query: 148 LTKVETRLKEKIVAEMTDLNKHIKQAQT---QRKQLLEESRELHREKLLVQAENRFFLEY 204
L + E +LKE + H +Q T +R+ L E ++ ++ E LE
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619
Query: 205 LTNKTEEYTEQPEKVWNSYLQKSGE--------------IERRRQESASRYAEQISVLKT 250
L + + E + S Q E +E RQE A Q++ L+
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA-QVAELEL 678
Query: 251 ALLQKENIQSSLKR----KLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 306
L ++ + +R K Q + LKE + +L+EE K+ A+ + + +
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEE-KRRAADALEEQQRCIS 737
Query: 307 QLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKK 366
+L E R L +Q KR+R+EL + K R + + E + ++
Sbjct: 738 ELKAETRSLVEQ---------HKRERKELEEERAGRKGLEAR-LQQLGEAHQAETEVLRR 787
Query: 367 ELLQLIEQAQKLTATQSHLENRKQQLQQE 395
EL + + A Q E+ +QL +E
Sbjct: 788 ELAEAM-------AAQHTAESECEQLVKE 809
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 58.5 bits (140), Expect = 1e-08
Identities = 55/254 (21%), Positives = 117/254 (46%), Gaps = 16/254 (6%)
Query: 156 KEKIVAEMTDLNKHIKQAQTQ-RKQLLEESRELHREKLLV----QAENRFFLEYLTNKTE 210
++K + +L + ++ + + R+Q++E+ + E+ L+ + E LEY+ E
Sbjct: 236 RQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQE 295
Query: 211 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA-LLQKENIQSSLKRKLQAM 269
E + E+ L+ EI+R E+ + AE ++ K A + E + + R+ +
Sbjct: 296 EDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFE 355
Query: 270 RDIAILKEKQEKEI---QTLQEETKKVQAET----ASKTREVQAQLLQEKRLLEKQLSEP 322
+ ++ ++EKEI + +QE+ + QAE A + +EV + + K +
Sbjct: 356 AEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKME 415
Query: 323 DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 382
L K + ++ K AL + +R E+ + + +Q +KE L E+ +K T
Sbjct: 416 TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL---EEEKKATGRL 472
Query: 383 SHLENRKQQLQQEQ 396
H ++Q+++ Q
Sbjct: 473 QHANELRRQVRENQ 486
Score = 31.6 bits (70), Expect = 1.5
Identities = 33/164 (20%), Positives = 68/164 (41%), Gaps = 13/164 (7%)
Query: 155 LKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTE 214
L+ K E+ D K+ + RK++ E EL + +L A L + + E
Sbjct: 389 LRAKRNQEVADREWRRKEKENARKKM-ETEAELRKSRLEQVAFKEHALAVQVQRDRDEFE 447
Query: 215 QPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 274
+ + ++K E ++ ++A ++ +EN Q ++ ++ +
Sbjct: 448 RILRAQREQIEKERLEEEKKATGRLQHANELR-----RQVRENQQKEVQNRIATFEEGRR 502
Query: 275 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ 318
LKE+ +K + + E +K K E++A L EK +E +
Sbjct: 503 LKEEAQKRRERIDEIKRK-------KLEELRATGLPEKYCIEAE 539
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 58.2 bits (139), Expect = 1e-08
Identities = 64/272 (23%), Positives = 136/272 (50%), Gaps = 28/272 (10%)
Query: 135 YHSLINNFVKPE-KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLL 193
+ S+ + +KPE +L + +L+ + V E L + +Q QTQ+ Q E + L +++ L
Sbjct: 138 HQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQ---EQQVLQQQEQL 194
Query: 194 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
Q + L + +E +Q + LQ+ ++++++ + +Q L L
Sbjct: 195 QQQVQE---QQLLQQQQEQLQQQQ-----LLQQQEQLQQQQFQQQQEQLQQQQQL-LLLQ 245
Query: 254 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
Q+ +Q L ++ QA +L+++Q + LQ++ Q E + ++ Q Q+++
Sbjct: 246 QQGQLQQQLLQQQQAQLQQQLLEQQQAQ----LQQQLLLQQQEQLQQQQQQQLLQQQQEQ 301
Query: 314 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR----ENQQFKKEL- 368
L ++QL P L + E+ ++ + L +++ + + + R E QQ +++L
Sbjct: 302 LQQQQLQPPP---LEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQ 358
Query: 369 LQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 400
L+L E+ Q+L + LE ++QQL+Q++ LE
Sbjct: 359 LKLQEELQQL---EQQLEQQQQQLEQQEVQLE 387
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/250 (24%), Positives = 116/250 (46%), Gaps = 37/250 (14%)
Query: 179 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 238
++ EE+R RE L Q E + E +QP+ Q E++++ Q+
Sbjct: 77 EIAEETRPGQRELQLQQLEQQ----------PEPQQQPQHEQLQQPQPHLELQQQPQQDG 126
Query: 239 SRYAEQISVLKTALLQKENIQS----SLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQ 294
+ Q LQ+E QS LK +LQ M L+ +Q +E Q LQ++ +++Q
Sbjct: 127 QQQLSQ--------LQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQ 178
Query: 295 AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS 354
+ A + Q+LQ++ L++Q+ E + + ++ + Q +L ++F +
Sbjct: 179 TQQAQ-----EQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-- 231
Query: 355 CGINRENQQFKKELLQLIEQA----QKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 410
+E Q +++LL L +Q Q L Q+ L+ + + QQ Q + L+Q +++LQ
Sbjct: 232 ----QEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQ 287
Query: 411 GSHNQCLNRQ 420
Q L +Q
Sbjct: 288 QQQQQQLLQQ 297
Score = 50.1 bits (118), Expect = 4e-06
Identities = 75/344 (21%), Positives = 155/344 (45%), Gaps = 39/344 (11%)
Query: 95 PDASAHSLAVTLSEL-HSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKLTKVET 153
P A S V SE+ R Q E + + P P H + +P+ +++
Sbjct: 64 PQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQ---QPQPHLELQQ 120
Query: 154 RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLL----VQAENRFFLEYLTNKT 209
+ ++ +++ L + K ++L E + +H+++ L VQ + R + +T
Sbjct: 121 QPQQDGQQQLSQLQQE-KHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQT 179
Query: 210 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 269
++ EQ LQ+ + ++ Q+ + +Q + + LQ++ Q + +LQ
Sbjct: 180 QQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-QEQLQQQ 238
Query: 270 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ---LSEPDRRL 326
+ + +L+++ + + Q LQ++ QA+ + E Q LQ++ LL++Q + ++L
Sbjct: 239 QQLLLLQQQGQLQQQLLQQQ----QAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQL 294
Query: 327 LGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQL-IEQAQKLTATQSHL 385
L +++ + + Q L + E ++ + EL+ + + Q+L + L
Sbjct: 295 LQQQQEQLQQQQLQPPPLEPE------------EEEEVELELMPVDLGSEQELEQQRQEL 342
Query: 386 ENRKQQL--QQEQWYL-----ESLIQARQRLQGSHNQCLNRQDV 422
E R+Q+L QQEQ L E L Q Q+L+ Q L +Q+V
Sbjct: 343 E-RQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQ-LEQQEV 384
Score = 37.0 bits (84), Expect = 0.036
Identities = 39/177 (22%), Positives = 88/177 (49%), Gaps = 17/177 (9%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREK---LLVQAENRFFLEYLT 206
+++ +L ++ A++ +QAQ Q++ LL++ +L +++ LL Q + + + L
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQ 308
Query: 207 NKTEEYTEQPE---KVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK 263
E E+ E ++ L E+E++RQE R E L+++ Q L+
Sbjct: 309 PPPLEPEEEEEVELELMPVDLGSEQELEQQRQE-LERQQE---------LERQQEQRQLQ 358
Query: 264 RKLQA-MRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQL 319
KLQ ++ + E+Q+++++ + + + E ++ +EVQ +L + L+ +L
Sbjct: 359 LKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLEL 415
Score = 36.6 bits (83), Expect = 0.047
Identities = 42/274 (15%), Positives = 118/274 (43%), Gaps = 52/274 (18%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEKL 148
ELQ Q L+ E H Q+ + + ++L P + ++
Sbjct: 117 ELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQ 176
Query: 149 TKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNK 208
+ + +++++ + L Q Q Q +QLL++ +E +++ L+Q + + + +
Sbjct: 177 LQTQQAQEQQVLQQQEQL-----QQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ 231
Query: 209 TEEYTEQPEKVWNSYLQKSGEIERRR-------------QESASRYAEQISVLKTALLQK 255
E+ +Q + + LQ+ G+++++ ++ ++ +Q+ + + LQ+
Sbjct: 232 QEQLQQQQQLL---LLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQ 288
Query: 256 ENIQSSLKRKLQAMRDIAIL------KEKQEKEIQTL----------------------- 286
+ Q L+++ + ++ + +E++E E++ +
Sbjct: 289 QQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQEL 348
Query: 287 --QEETKKVQAETASKTREVQAQLLQEKRLLEKQ 318
Q+E +++Q + + ++++ QL Q+++ LE+Q
Sbjct: 349 ERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQ 382
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.4 bits (137), Expect = 3e-08
Identities = 71/312 (22%), Positives = 138/312 (44%), Gaps = 37/312 (11%)
Query: 139 INNFVKPEKLTKVETRLKEKIVAEMTDLNKH----IKQAQTQRKQLLEESRELHREKLLV 194
I N K K E + ++ + +L K +K+A K L+ +L EKL
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 195 QAENRFFLEYLTNKTEEYTEQPEKVWNS-------YLQKSGEIERRRQESASRYAEQISV 247
Q N LE LT++ E+ E++ + Y ++E ++S E+I+
Sbjct: 919 QQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 248 LKTALLQKENIQSSLKRKLQAMR-DIAILKEKQEKE--IQT---LQEETKKVQAETASKT 301
L+ L + N L+++L+ ++ + LK++Q++E +Q+ + E K + E+ T
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 302 REV-------------QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKR 348
RE+ A L EK+ L+ QL + + + + + L ++ Q + L +
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN-NNLQAQILALQRQTVSLQEQN 1096
Query: 349 FIFE-YSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL----ESLI 403
+ + + EN + L+ Q +L QS LEN + + +E+ L +SLI
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156
Query: 404 QARQRLQGSHNQ 415
+ ++L+ H +
Sbjct: 1157 KDHEKLELLHER 1168
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/261 (24%), Positives = 118/261 (45%), Gaps = 30/261 (11%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E R+K+ I E L++ IK+ ++ ++ E R++ +E LE+ K E
Sbjct: 579 EARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKE-----------LEHYKEKGER 626
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
E ++ +L+K E+ +++ + E+I L+ + E LK+ L + ++
Sbjct: 627 AEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 272 IAILKEKQEKEIQTLQEETKKVQ--AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
+ E EKE L EE +++ E+ AQL E + LE SE ++ G
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE---SEKEQLKKGL 741
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 389
+ K + L+++ + G++ ENQ+ +K L ++ Q+L + LE
Sbjct: 742 ELLKASFKKTERLEVSYQ--------GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 390 QQLQQEQWYLESLIQARQRLQ 410
Q LQ+ LE L + +RL+
Sbjct: 794 QTLQKN---LEELKISSKRLE 811
Score = 48.5 bits (114), Expect = 1e-05
Identities = 76/343 (22%), Positives = 154/343 (44%), Gaps = 30/343 (8%)
Query: 70 FEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPR 129
++ + + EL H E + ++ +L +T ++ + L+ E +S R
Sbjct: 620 YKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEA---LEQE--NSELERENR 673
Query: 130 RLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHR 189
+L S N + E L K ++L E+ + E+ + +K A + QL E++EL
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENL-ELRRNVESLKCASMKMAQLQLENKELES 732
Query: 190 EKLLVQAENRFFLEYLTNKTE--EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISV 247
EK ++ + L+ KTE E + Q + N LQK+ E ++ I
Sbjct: 733 EKEQLK-KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK----------IQQ 781
Query: 248 LKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQ 307
L++ L E +L++ L+ ++ + E+ EKE ++L++ET +++ + + Q
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--------KKQ 833
Query: 308 LLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKE 367
L +E + L +Q D L + + N++ + L+ + I++ SC +E ++ KE
Sbjct: 834 LEKENKRLRQQAEIKD-TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 368 LLQLIE-QAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRL 409
L++ + L + L + K + QQ LE L +++
Sbjct: 893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Score = 45.1 bits (105), Expect = 1e-04
Identities = 56/289 (19%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
++E + K + E+ + N ++ AQ KQ ++ES L E LE ++ +T
Sbjct: 395 EMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWE-----------LEQIS-RT 439
Query: 210 EEYTEQPEKVWNSYLQK--SGEIERRRQESASRYAEQISVLKTA----------LLQKEN 257
E +E P+K + + S + + E+ S + + L+T +L+ E
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 258 IQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
L +K++ + + + +++ + Q L ++ K +A+ ++ ++ ++LE+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 318 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS--------CGINRENQQFKKEL- 368
+ ++ + R+R +++ +A+ + + I S I E +Q KKEL
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 369 --LQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 415
+ E+A++L HLE + LQ++ L+ + + L+ +++
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Score = 42.7 bits (99), Expect = 6e-04
Identities = 51/272 (18%), Positives = 120/272 (44%), Gaps = 27/272 (9%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSR---FAEG 127
+ +T L+E +T ++ + QV +++ +S + +L ++ +Q L++ +
Sbjct: 1086 QRQTVSLQEQNTTLQ-TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 128 PRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVA--------------EMTDLNKHIKQA 173
L Y SLI + K E L + + E +++ E DL Q
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 174 QTQRKQL--LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 231
Q+ QL LE+ ++ +EK+L++ +N E + + ++ + +++ ++Y Q E E
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNH---ETVAAEYKKLCGENDRLNHTYSQLLKETE 1261
Query: 232 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK 291
+ + + S+L + L++ +++ + + + + I K + + L +
Sbjct: 1262 VLQTD----HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317
Query: 292 KVQAETASKTREVQAQLLQEKRLLEKQLSEPD 323
++ E ++Q +LQ + LLE+ + D
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 57.4 bits (137), Expect = 3e-08
Identities = 62/244 (25%), Positives = 111/244 (45%), Gaps = 27/244 (11%)
Query: 154 RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT 213
+ EK++A LN + Q K L + REL K V +E + L+NK E+
Sbjct: 264 KTNEKLIAH---LNIQVDFLQQANKDLEKRIRELMETKETVTSE----VVNLSNKNEKLC 316
Query: 214 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 273
++ ++ Q + ++ER ++E VL+TA + + +KRKL M+D+
Sbjct: 317 QELTEID----QLAQQLERHKEE----------VLETADKELGEAKKEIKRKLSEMQDLE 362
Query: 274 ILKEKQEKEIQTLQEETKKVQAETASKT--REVQAQLLQEKRLLEKQLSE---PDRRLLG 328
K + E+ Q+E +++ E K+ V QL QEK+ L K++ +R+L
Sbjct: 363 ETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTL 422
Query: 329 KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENR 388
+ +R L + + R + + GI E +KKEL +L Q+ + + S+
Sbjct: 423 EVERMRLEHGIKRRDRSPSR-LDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSARE 481
Query: 389 KQQL 392
K +
Sbjct: 482 KSSI 485
Score = 37.0 bits (84), Expect = 0.036
Identities = 52/280 (18%), Positives = 114/280 (40%), Gaps = 15/280 (5%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E A++ L + I + + EE+ + + ++ E F E + KTE+
Sbjct: 695 ESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQ 754
Query: 217 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQA----MRDI 272
E + N + + + S ++ LK L+ ++ +SL+R+L A + ++
Sbjct: 755 ENLAN-----KEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV 809
Query: 273 AILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL---LEKQLSEPDR--RLL 327
+E KE + LQ++ + E + E++A + +++ + + K ++E R L+
Sbjct: 810 GRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLM 869
Query: 328 GKRKRRELNMKAQALKLAAKRFIFEYSC-GINRENQQFKKELLQLIEQAQKLTATQSHLE 386
+++ ++ + L + +E E+ + ELL + + + L LE
Sbjct: 870 AAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLE 929
Query: 387 NRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTT 426
Q+ ES I + + + L Q+ K T
Sbjct: 930 KEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKAT 969
Score = 29.3 bits (64), Expect = 7.4
Identities = 35/183 (19%), Positives = 83/183 (45%), Gaps = 21/183 (11%)
Query: 229 EIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQE 288
E R +E+ Y E + + + + + +++SLK+ + D+ L + +++ L++
Sbjct: 74 ENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
Query: 289 ETKKVQAETASKTREVQAQLLQEKRL--LEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 346
E SK + + Q LQEK L + + R + +R+R +++ ++++
Sbjct: 134 E---------SKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSS 184
Query: 347 -------KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL 399
+I + + Q+ ++E+ QL E KL +S + + +Q++ + +
Sbjct: 185 YPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE---KLAMMESGVRDYSKQIELREREI 241
Query: 400 ESL 402
E L
Sbjct: 242 ERL 244
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/321 (25%), Positives = 140/321 (43%), Gaps = 61/321 (19%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF-LEY 204
+ L +L +++ DLN+ I +Q+KQLLE + ++E EN++ LE
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE-----LENKYAKLEE 2574
Query: 205 LTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENI---QSS 261
++EE E + +N+ LQ+ + + ES Q++ TAL ++ + +
Sbjct: 2575 KLKESEEANEDLRRSFNA-LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
Query: 262 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL------ 315
LK K + + ++ L +K I L+EE VQ E A K E++ +L +E + L
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGI 2693
Query: 316 --------EKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCG--------INR 359
E++++E R L+ + +++ L + + L A+ F S N
Sbjct: 2694 MRNETETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752
Query: 360 ENQQFK-------KELLQLIEQ--------------AQKLTATQ----SHLENRKQQLQQ 394
E + K KEL QL EQ A + +T+ SHLE QQL
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 395 EQWYLESLIQARQRLQGSHNQ 415
+ E L+ +L+ S+NQ
Sbjct: 2813 KD---EQLLHLSSQLEDSYNQ 2830
Score = 52.0 bits (123), Expect = 1e-06
Identities = 56/239 (23%), Positives = 109/239 (45%), Gaps = 29/239 (12%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 216
E + +EM +L K + + + +++QL++E ++ E ++ E +LE + +E +
Sbjct: 1952 ELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE---IRKE---YLEKIQGAQKEPGNKS 2005
Query: 217 E-KVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAIL 275
K L++ + ++ Q+ RY E+IS L+ + E +Q+ ++ +D+ I
Sbjct: 2006 HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT------ESQKDLEIT 2059
Query: 276 KEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK-RRE 334
KE + + E KK QAE AS K LL+ SE R L K ++E
Sbjct: 2060 KENLAQAV----EHRKKAQAELAS-----------FKVLLDDTQSEAARVLADNLKLKKE 2104
Query: 335 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 393
L +++K K+ + + + ++ KE + E+ L + HLE ++Q
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ 2163
Score = 50.1 bits (118), Expect = 4e-06
Identities = 59/278 (21%), Positives = 126/278 (45%), Gaps = 27/278 (9%)
Query: 154 RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT 213
+LK A++T LNK+I++ + Q +L + E+L ++ E K +
Sbjct: 95 KLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ-SEEQLSKHDKSSTEEEMEIEKIKHKL 153
Query: 214 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKL-QAMRDI 272
++ E++ ++ + + + + +S E+ ++K L +KE S+L+ +L Q +
Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 213
Query: 273 A---ILKEKQEK-EIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLG 328
A +++EK + E Q E + +Q T + +V+ ++ Q+ R+L+++L E + L+G
Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQA---DVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 329 K-------------RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA 375
+ ++R + Q ++ A+ + RE + E ++L
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330
Query: 376 QKLT-----ATQSHLENRKQQLQQEQWYLESLIQARQR 408
+KL+ HL + +Q Q Q LES A ++
Sbjct: 331 RKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ 368
Score = 47.4 bits (111), Expect = 3e-05
Identities = 61/278 (21%), Positives = 120/278 (43%), Gaps = 48/278 (17%)
Query: 170 IKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 229
+++ +QL+ E +++ R+K + + +E ++ K ++ ++K
Sbjct: 50 VQERLAYAEQLVVELKDIIRQK-----------DVQLQQKDEALQEERKAADNKIKKLKL 98
Query: 230 IERRRQESASRYAEQI-----SVLKTALLQKENIQSSLKRKLQAMRDIAILKEK-QEKE- 282
+ + S ++Y E++ +VL T +E + K + +I +K K QEKE
Sbjct: 99 HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 283 -IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 341
I TLQ + + QAE +++ + ++E ++++QL E + + + +
Sbjct: 159 LISTLQAQLTQAQAEQPAQS----STEMEEFVMMKQQLQEKEEFI----STLQAQLSQTQ 210
Query: 342 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA-------QKLTATQSHLENRKQQ--- 391
+ AA++ + E + + + ELLQL+ QA QKL Q LE ++
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 392 -------LQQEQWYLES----LIQARQRLQGSHNQCLN 418
LQQE E L Q Q+++ HN N
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRN 308
Score = 44.7 bits (104), Expect = 2e-04
Identities = 66/320 (20%), Positives = 136/320 (42%), Gaps = 60/320 (18%)
Query: 137 SLINNFVKPEKLTKVETRLKEKIVAE-MTDLNKHIKQAQTQR---KQLLEESRELHREKL 192
S + VK + + E++ +I E + +H K+AQ + K LL++++ E
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS---EAA 2092
Query: 193 LVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTAL 252
V A+N +E E V + QK ++ERR +++ ++ ++ ++ L
Sbjct: 2093 RVLADN-------LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 253 --LQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA---- 306
L++E + + + +I + K++KE+Q LQE + A+ T+ + +
Sbjct: 2146 DALRREKVHLE-----ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 307 --QLLQEKRLLEKQLSE------------PDRRLLGKRKRRELNMKAQALKLAAKRF--- 349
+++ E + E++ S+ D + K + R++++ + LK+ R
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 350 --IFEYSCGINRENQQ--------FKKELLQLIEQAQ--------KLTATQSHLENRKQQ 391
I+E + QQ KELL +E+ + +L +S L++ K Q
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320
Query: 392 LQQEQWYLESLIQARQRLQG 411
L LE + + L+G
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEG 2340
Score = 43.9 bits (102), Expect = 3e-04
Identities = 54/251 (21%), Positives = 114/251 (45%), Gaps = 30/251 (11%)
Query: 144 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 203
KPE++ + E+R K++I + ++ A RK+ L+E++ L E L + +
Sbjct: 1467 KPEEIGE-ESRAKQQI-------QRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
Query: 204 YLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK 263
L + + + Q K ++ L + ++ R + I+ + +LL+ +++ SS +
Sbjct: 1519 SLADVESQVSAQ-NKEKDTVLGRLALLQEERDKL-------ITEMDRSLLENQSLSSSCE 1570
Query: 264 RKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQ---LLQEKRLLEKQ-- 318
A+ + KEK KEI++L+ E K +E+Q + LLQ + +
Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Query: 319 --------LSEPDRRLLGKRKRRELNMKAQALKL-AAKRFIFEYSCGINRENQQFKKELL 369
+ + + L GK + E N K +L A++ + E + + + ++++L
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Query: 370 QLIEQAQKLTA 380
+L E+ +L A
Sbjct: 1691 ELEEENDRLRA 1701
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/240 (21%), Positives = 112/240 (46%), Gaps = 25/240 (10%)
Query: 172 QAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 231
Q T Q+ + +E+ EK+ ++ + +++ T E T++ E+V+
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELK-------VSSTTSELTKKSEEVF----------- 1340
Query: 232 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK 291
+ QE ++ +I LKT + E SL++KL++ + + I + +E+Q +E +
Sbjct: 1341 -QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ-LQIAGLEHLRELQPKLDELQ 1398
Query: 292 KVQAETASKTREVQAQLLQEKRLLEK-QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 350
K+ ++ + QL +++ L K Q ++ L K +L M+A+ K+
Sbjct: 1399 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 351 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 410
E C + ++ ++ +E + +KL Q+ L +RK+ L++ + E L AR ++
Sbjct: 1459 VEL-CEMKQKPEEIGEESRAKQQIQRKL---QAALISRKEALKENKSLQEELSLARGTIE 1514
Score = 36.2 bits (82), Expect = 0.061
Identities = 53/225 (23%), Positives = 97/225 (43%), Gaps = 36/225 (16%)
Query: 144 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL----LEESRELHREKLLVQAENR 199
K ++TK++ L EK ++ L + I++ Q ++ E+ +L+ EK + E +
Sbjct: 871 KELEITKMDQLLLEK-KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Query: 200 FFLEYLT------NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 253
E L +E E+ +V + Q E+ Q S + +LK
Sbjct: 930 TLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK---- 985
Query: 254 QKENIQSSLKRKLQAM---------------RDIAILKEKQEKEIQTLQEETKKVQAETA 298
KEN Q KRKLQA ++A LK++ +KEI + E +V+ +
Sbjct: 986 -KENEQR--KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042
Query: 299 SK---TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 340
+K + V ++ + + L++ +SE + L RK E + A+
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087
Score = 36.2 bits (82), Expect = 0.061
Identities = 71/337 (21%), Positives = 131/337 (38%), Gaps = 54/337 (16%)
Query: 107 SELHSCRDLQDECLDSRFA------EGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIV 160
+E+H D EC+++ + E R+ Y +L F + L + L E
Sbjct: 1701 AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF---QSLMSEKDSLSE--- 1754
Query: 161 AEMTDLNKHIKQAQTQRKQLLEESRELHREKLLV----------QAENRFFLEYLTNKTE 210
E+ DL I+ +++ L E+ E H + V + E + L T T
Sbjct: 1755 -EVQDLKHQIEGNVSKQANL--EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811
Query: 211 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 270
+ K N + K + + + Y +QI LK + E + K Q +
Sbjct: 1812 SESVPSAKSANPAVSK----DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867
Query: 271 DI--AILKEKQEK--EIQTLQEETKKVQA------ETASKTREVQAQLLQEKRLLEKQLS 320
+ +L + K E++ LQEE K+ E S+ +++ +EK LE++L
Sbjct: 1868 NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM 1927
Query: 321 EPDRRLLG------------KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQ---QFK 365
L G + K L + + LK E + + + + +
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 366 KELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 402
KE L+ I+ AQK +SH + ++ L+++Q ++ L
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Score = 35.0 bits (79), Expect = 0.14
Identities = 39/190 (20%), Positives = 71/190 (37%), Gaps = 21/190 (11%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLE---------------------ES 184
EKL K LK +AE T+ + K+ Q + + LL+ E
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
Query: 185 RELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQ 244
+EL+ + +A + + L +E E EK+ K +I +E+ AE
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 245 ISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREV 304
TA E + SS + + + + E K+ Q+L E + E ++
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 305 QAQLLQEKRL 314
+ + ++ L
Sbjct: 1764 EGNVSKQANL 1773
Score = 32.0 bits (71), Expect = 1.1
Identities = 29/177 (16%), Positives = 77/177 (43%), Gaps = 14/177 (7%)
Query: 159 IVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEK 218
+ ++ ++ ++KQ ++++ L+ R+ EKL + + + ++ + ++ T Q +
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 219 VWNSYLQKSGEIER--------RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 270
+ + I++ +S + E + + E+ + L+ K+ A+
Sbjct: 1111 LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE 1170
Query: 271 DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEK---RLLEKQLSEPDR 324
KE+ +K++Q K + + K R ++ +L Q+K L++Q E +
Sbjct: 1171 KE---KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
Score = 29.3 bits (64), Expect = 7.4
Identities = 48/227 (21%), Positives = 98/227 (43%), Gaps = 35/227 (15%)
Query: 187 LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQIS 246
+ +E+ + ++R E N + ++ + L +I + Q+ R QI
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694
Query: 247 VLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEIQT-------LQEETKKV--QAE 296
L+ + + I + +L K + + ++ L E+ +K L EE ++ Q +
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 297 TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFE--YS 354
S E++AQ+ Q LE L+E +R+ R L+ ++Q A + E +S
Sbjct: 755 ELSMVTELRAQVKQ----LEMNLAEAERQ-------RRLDYESQT---AHDNLLTEQIHS 800
Query: 355 CGINRENQQFKKELLQ---------LIEQAQKLTATQSHLENRKQQL 392
I +++ K E+LQ EQ+ + + QS L+N++ ++
Sbjct: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV 847
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 57.0 bits (136), Expect = 3e-08
Identities = 61/270 (22%), Positives = 123/270 (45%), Gaps = 15/270 (5%)
Query: 148 LTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTN 207
L K++ + E + E ++Q Q + L +E + R+ L + EN L L
Sbjct: 137 LFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQ-LQAEVENNQMLSLLNR 195
Query: 208 KTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA----LLQKENIQSSLK 263
+ EE + E+ ++ E E R E R EQ L+ Q+E ++ +
Sbjct: 196 RQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEE 255
Query: 264 RKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLL-QEKRLLEKQ--LS 320
R + + +E+ ++ + L E+ +++ E + RE + +L QE+RL E++ L
Sbjct: 256 RLCEQEERLCEQEERLREQEERLHEQEERL-CEQEERLREQEERLCEQEERLREQEERLC 314
Query: 321 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
E + RL + +E + Q +R + E + +E +Q ++E +L+E+ + L
Sbjct: 315 EQEERL----REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQE--RLLERERLLEE 368
Query: 381 TQSHLENRKQQLQQEQWYLESLIQARQRLQ 410
+ LE + + Q E+ + + +Q +RL+
Sbjct: 369 VEELLEQERLRQQDERLWQQETLQELERLR 398
Score = 40.4 bits (93), Expect = 0.003
Identities = 39/179 (21%), Positives = 85/179 (47%), Gaps = 25/179 (13%)
Query: 259 QSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL---------- 308
+S K K Q +A +++ LQ+ET ++ E S R++QA++
Sbjct: 135 RSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLN 194
Query: 309 -LQEKRLLEKQ--LSEPDRRLLGKRKR---RELNMKAQALKLAAKRFIFEYSCGINRENQ 362
QE+RL E++ L E + RL + +R +E ++ Q +L + E C + +
Sbjct: 195 RRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQE---ERLC---EQEE 248
Query: 363 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 421
+ ++ +L EQ ++L + L ++++L +++ E L + +RL+ + +++
Sbjct: 249 RLREHEERLCEQEERLCEQEERLREQEERLHEQE---ERLCEQEERLREQEERLCEQEE 304
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 57.0 bits (136), Expect = 3e-08
Identities = 78/374 (20%), Positives = 156/374 (41%), Gaps = 51/374 (13%)
Query: 74 TNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGP-RRLL 132
T +L EL E +T+ +A AH+L S H C L+++ + + A+ +R L
Sbjct: 1313 TQQLEELKR----QMEEETKAKNAMAHALQ---SSRHDCDLLREQYEEEQEAKAELQRAL 1365
Query: 133 PPYHSLINNFVKPEKLTKVET---RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHR 189
+S + + TK ET + E++ L + +++A+ + + L +
Sbjct: 1366 SKANSEVAQW-----RTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420
Query: 190 EKLLVQAENRFFLEYLT---------NKTEEYTEQPEKVWNSYLQKS-GEIERRRQESAS 239
K +Q E + L +K + ++ W L +S E+E ++ES S
Sbjct: 1421 TKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS 1480
Query: 240 ----------RYAEQISVLKTALLQKENIQSSLK----------RKLQAMRDIAILKEKQ 279
Y E + L+T + +N+Q + + LQ L E++
Sbjct: 1481 LSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQE 1540
Query: 280 EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA 339
+ ++Q EE + SK VQ +L Q K L++++ E D + ++ +R A
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEI--EQLKRNSQRAA 1598
Query: 340 QALKLAAKRFIFEYSCGINRENQQ---FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 396
+AL+ I + + + + + +QL +++ TQ HL + QL+ Q
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQ 1658
Query: 397 WYLESLIQARQRLQ 410
+L+ +++ + L+
Sbjct: 1659 LHLDDALRSNEDLK 1672
Score = 44.7 bits (104), Expect = 2e-04
Identities = 60/302 (19%), Positives = 128/302 (42%), Gaps = 40/302 (13%)
Query: 146 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL---------LEESRELHREKLLVQA 196
E+ + E L+ KI + +DL + +++ + ++ + + RE +K+
Sbjct: 1123 EEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL 1182
Query: 197 ENRFFLEYLTNKT------EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKT 250
E T T + E E++ N K ++E+ + E + S ++
Sbjct: 1183 EEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ-KLEKEKSELKMEIDDMASNIEA 1241
Query: 251 ALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQ----- 305
K NI+ + + +I E+Q + I L + ++Q + + V+
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301
Query: 306 -AQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR----E 360
+QL + K+ L +QL E R++ + K + N A AL+ + + C + R E
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQMEEETKAK--NAMAHALQSS------RHDCDLLREQYEE 1353
Query: 361 NQQFKKELLQLI-----EQAQKLTATQSHLENRKQQLQQEQWYL-ESLIQARQRLQGSHN 414
Q+ K EL + + E AQ T ++ R ++L++ + L + L +A + + +++
Sbjct: 1354 EQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANS 1413
Query: 415 QC 416
+C
Sbjct: 1414 KC 1415
Score = 42.7 bits (99), Expect = 6e-04
Identities = 46/180 (25%), Positives = 89/180 (49%), Gaps = 18/180 (10%)
Query: 247 VLKTALLQKE--NIQSSLKR-KLQAMRDIAILKEKQEKEIQTLQEETK---KVQAETAS- 299
+LK+A +KE ++ +R K + R A KE +EK + LQE+ +VQ+ET +
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 300 -KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 358
E L++ K LLE ++ E RL + E+N + +A KR + + +
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERL---EEEEEMNSEL----VAKKRNLEDKCSSLK 955
Query: 359 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 418
R+ + L L + ++ AT++ ++N +++ + + L + ++ LQ +H Q L+
Sbjct: 956 RDIDDLE---LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD 1012
Score = 38.5 bits (88), Expect = 0.012
Identities = 59/269 (21%), Positives = 117/269 (43%), Gaps = 31/269 (11%)
Query: 139 INNFVKPEKLTKVETRLKEKIVA--EMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 196
+N F K + L K KE + + + +++ +RK+L E+ L +EK +Q
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 197 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKE 256
+ + ++TE + E+ ++ +E + +E R E+ + + +K
Sbjct: 894 Q-------VQSETENLMDAEERC-EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 257 NIQ---SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 313
N++ SSLKR + D+ + K EKE + + K + E + + ++L +EK
Sbjct: 946 NLEDKCSSLKRDID---DLELTLTKVEKEKHATENKVKNLSEEMTALEENI-SKLTKEK- 1000
Query: 314 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIE 373
K L E ++ L + E + +K+ AK + + + + +Q KK L
Sbjct: 1001 ---KSLQEAHQQTLDDLQVEEDKVNG-LIKINAK--LEQQTDDLEGSLEQEKKLRADLER 1054
Query: 374 QAQKLTA-------TQSHLENRKQQLQQE 395
+KL + LEN KQQ++++
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Score = 37.4 bits (85), Expect = 0.027
Identities = 69/319 (21%), Positives = 125/319 (39%), Gaps = 70/319 (21%)
Query: 157 EKIVAEMTDLNKHIKQAQTQRKQLLEES-------RELHREKLLVQAEN---RFFLEYLT 206
E++V ++ L + K Q + L E+ +E + K LV+ E + LE +
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 207 NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLK-TALLQKENIQSSLKRK 265
E + +V Q E++R+ E E+I LK + E +QS L +
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKD----EEIEQLKRNSQRAAEALQSVLDAE 1608
Query: 266 LQAMRDIAILKEKQEKEIQTLQEE---TKKVQAETASKTREVQAQL----------LQEK 312
+++ D LK+K E ++ ++ + + + AET R VQ QL L+
Sbjct: 1609 IRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSN 1668
Query: 313 RLLEKQLSEPDRR------------LLGKRKRRELNMKAQALKLAAKRFIFEYS------ 354
L++QL+ +RR + ++ R + Q L A+ R +S
Sbjct: 1669 EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLI 1728
Query: 355 ------------CGINREN---------QQFKKELLQ---LIEQAQKLTATQSHLENRKQ 390
C EN ++ KK + + E+ +K T +HLE K+
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 391 QLQQEQWYLESLIQARQRL 409
L+Q L+ + ++L
Sbjct: 1789 NLEQTVKDLQHRLDEAEQL 1807
Score = 33.9 bits (76), Expect = 0.30
Identities = 59/315 (18%), Positives = 133/315 (42%), Gaps = 67/315 (21%)
Query: 146 EKLTKVETR---LKEKIVAEMTDLNKHIKQAQTQRKQLL---EESRELHREKLLVQAENR 199
E+L + E R L+EK+V+ + + N Q Q++ + L+ E L + K+L++A+ +
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVK 924
Query: 200 FFLEYLTNKTEEYTEQPEKVWN------SYLQKSGEIE------RRRQESASRYAEQISV 247
E L + E +E K N S + ++E + + + + +S
Sbjct: 925 ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984
Query: 248 LKTALLQKENIQSSLKRKL-------QAMRDIAILKEK-------------QEKEIQTLQ 287
TAL +ENI K K Q + D+ + ++K Q +++
Sbjct: 985 EMTAL--EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 288 EETKKVQAETASKTREVQAQLLQ----------EKRLLEKQLSEPDRRLLGKRKRRELNM 337
E+ KK++A+ R+++ L +K+ +E++L K++E +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL-----------KKKEFEL 1091
Query: 338 KAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQW 397
K+ ++ +S ++ ++ + + +L E+ + ++ +E ++ L +E
Sbjct: 1092 SQLQAKIDDEQV---HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE-- 1146
Query: 398 YLESLIQARQRLQGS 412
LE + + + G+
Sbjct: 1147 -LEEISERLEEASGA 1160
Score = 28.9 bits (63), Expect = 9.7
Identities = 44/198 (22%), Positives = 81/198 (40%), Gaps = 20/198 (10%)
Query: 166 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
L I Q Q + + ++ESR + + E L K E+ T + L+
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKNLE 1791
Query: 226 KSGEIERRRQESASRYA-----EQISVLKTALLQKEN-IQSSLKRKLQAMR--------- 270
++ + + R + A + A +QI L+ + + EN + KR +A++
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851
Query: 271 -DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
++ E+ K I LQ+ K+QA+ S R QA+ +E+ + + L +
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKR--QAEEAEEQANTQLSRCRRVQHELEE 1909
Query: 330 RKRRELNMKAQALKLAAK 347
R ++Q KL AK
Sbjct: 1910 AAERADIAESQVNKLRAK 1927
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 57.0 bits (136), Expect = 3e-08
Identities = 71/313 (22%), Positives = 138/313 (44%), Gaps = 38/313 (12%)
Query: 139 INNFVKPEKLTKVETRLKEKIVAEMTDLNKH----IKQAQTQRKQLLEESRELHREKLLV 194
I N K K E + ++ + +L K +K+A K L+ +L EKL
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 195 QAENRFFLEYLTNKTEEYTEQPEKVWNS--------YLQKSGEIERRRQESASRYAEQIS 246
Q N LE LT++ E+ E++ + Y ++E ++S E+I+
Sbjct: 919 QQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA 977
Query: 247 VLKTALLQKENIQSSLKRKLQAMR-DIAILKEKQEKE--IQT---LQEETKKVQAETASK 300
L+ L + N L+++L+ ++ + LK++Q++E +Q+ + E K + E+
Sbjct: 978 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1037
Query: 301 TREV-------------QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK 347
TRE+ A L EK+ L+ QL + + + + + L ++ Q + L +
Sbjct: 1038 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN-NNLQAQILALQRQTVSLQEQ 1096
Query: 348 RFIFE-YSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL----ESL 402
+ + + EN + L+ Q +L QS LEN + + +E+ L +SL
Sbjct: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Query: 403 IQARQRLQGSHNQ 415
I+ ++L+ H +
Sbjct: 1157 IKDHEKLELLHER 1169
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/261 (24%), Positives = 118/261 (45%), Gaps = 30/261 (11%)
Query: 152 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 211
E R+K+ I E L++ IK+ ++ ++ E R++ +E LE+ K E
Sbjct: 579 EARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKE-----------LEHYKEKGER 626
Query: 212 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 271
E ++ +L+K E+ +++ + E+I L+ + E LK+ L + ++
Sbjct: 627 AEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 272 IAILKEKQEKEIQTLQEETKKVQ--AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 329
+ E EKE L EE +++ E+ AQL E + LE SE ++ G
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE---SEKEQLKKGL 741
Query: 330 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 389
+ K + L+++ + G++ ENQ+ +K L ++ Q+L + LE
Sbjct: 742 ELLKASFKKTERLEVSYQ--------GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 390 QQLQQEQWYLESLIQARQRLQ 410
Q LQ+ LE L + +RL+
Sbjct: 794 QTLQKN---LEELKISSKRLE 811
Score = 48.5 bits (114), Expect = 1e-05
Identities = 76/343 (22%), Positives = 154/343 (44%), Gaps = 30/343 (8%)
Query: 70 FEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPR 129
++ + + EL H E + ++ +L +T ++ + L+ E +S R
Sbjct: 620 YKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEA---LEQE--NSELERENR 673
Query: 130 RLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHR 189
+L S N + E L K ++L E+ + E+ + +K A + QL E++EL
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENL-ELRRNVESLKCASMKMAQLQLENKELES 732
Query: 190 EKLLVQAENRFFLEYLTNKTE--EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISV 247
EK ++ + L+ KTE E + Q + N LQK+ E ++ I
Sbjct: 733 EKEQLK-KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK----------IQQ 781
Query: 248 LKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQ 307
L++ L E +L++ L+ ++ + E+ EKE ++L++ET +++ + + Q
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--------KKQ 833
Query: 308 LLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKE 367
L +E + L +Q D L + + N++ + L+ + I++ SC +E ++ KE
Sbjct: 834 LEKENKRLRQQAEIKD-TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 368 LLQLIE-QAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRL 409
L++ + L + L + K + QQ LE L +++
Sbjct: 893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Score = 45.1 bits (105), Expect = 1e-04
Identities = 56/289 (19%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 150 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 209
++E + K + E+ + N ++ AQ KQ ++ES L E LE ++ +T
Sbjct: 395 EMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWE-----------LEQIS-RT 439
Query: 210 EEYTEQPEKVWNSYLQK--SGEIERRRQESASRYAEQISVLKTA----------LLQKEN 257
E +E P+K + + S + + E+ S + + L+T +L+ E
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 258 IQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
L +K++ + + + +++ + Q L ++ K +A+ ++ ++ ++LE+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 318 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS--------CGINRENQQFKKEL- 368
+ ++ + R+R +++ +A+ + + I S I E +Q KKEL
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 369 --LQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 415
+ E+A++L HLE + LQ++ L+ + + L+ +++
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Score = 42.7 bits (99), Expect = 6e-04
Identities = 51/272 (18%), Positives = 120/272 (44%), Gaps = 27/272 (9%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSR---FAEG 127
+ +T L+E +T ++ + QV +++ +S + +L ++ +Q L++ +
Sbjct: 1087 QRQTVSLQEQNTTLQ-TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145
Query: 128 PRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVA--------------EMTDLNKHIKQA 173
L Y SLI + K E L + + E +++ E DL Q
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1205
Query: 174 QTQRKQL--LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 231
Q+ QL LE+ ++ +EK+L++ +N E + + ++ + +++ ++Y Q E E
Sbjct: 1206 LKQKGQLEDLEKMLKVEQEKMLLENKNH---ETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
Query: 232 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK 291
+ + + S+L + L++ +++ + + + + I K + + L +
Sbjct: 1263 VLQTD----HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318
Query: 292 KVQAETASKTREVQAQLLQEKRLLEKQLSEPD 323
++ E ++Q +LQ + LLE+ + D
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
>gi|166295204 hypothetical protein LOC80127 [Homo sapiens]
Length = 529
Score = 56.6 bits (135), Expect = 4e-08
Identities = 56/260 (21%), Positives = 122/260 (46%), Gaps = 12/260 (4%)
Query: 162 EMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWN 221
E+T+L++ IK T R L + + +L +++ ++ + L YL + +E EK+
Sbjct: 44 EVTELSR-IKYRDTSRI-LAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQ 101
Query: 222 SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEK 281
+ + + + + +Y QI+ L+ QK + +L+A+R K + E+
Sbjct: 102 QLNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVER 161
Query: 282 EIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 341
E+ L+E + + R ++++ +EK LE++ +E +L +R E ++
Sbjct: 162 ELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQE-AEKKIIMLAERAHHEAIVQLN- 219
Query: 342 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ---QLQQEQWY 398
A R +F+ + + + KE L + +QKL + + L ++K+ L +E+
Sbjct: 220 ---DAGRNVFKENDYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLLVKEK-- 274
Query: 399 LESLIQARQRLQGSHNQCLN 418
+ L+Q R ++Q + +N
Sbjct: 275 IMQLVQQRSQIQTLQKKVVN 294
Score = 44.3 bits (103), Expect = 2e-04
Identities = 66/320 (20%), Positives = 137/320 (42%), Gaps = 51/320 (15%)
Query: 80 LSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLI 139
+S L++ + Q Q D L L+E + + L+ ++ L +H
Sbjct: 79 MSVLSYLKK--QDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQINELEGQFHQ-- 134
Query: 140 NNFVKPEKLTKVETRLKE---------KIVAEMTDLNKHIKQAQTQRKQLLE--ESR--- 185
K +++ + T LK ++ E+ DL ++++ + ++ L ESR
Sbjct: 135 ----KAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLRRLESRFFE 190
Query: 186 ELHR-----EKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR 240
E HR EK ++ R E + + ++ N YLQK+ + ++ +
Sbjct: 191 EKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKE--NDYLQKALAYHLKETDALQK 248
Query: 241 YAEQISVLKTALLQKENIQSSL-KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETAS 299
++++ T LL ++ I L K K+ + +Q +IQTLQ++ ++ +
Sbjct: 249 NSQKLQESHTLLLHQKEINDLLVKEKIMQL-------VQQRSQIQTLQKKVVNLETALSY 301
Query: 300 KTREVQAQL--LQEKRLLEKQLSEPD---RRLLGKRKRRELNMKAQALKLAAKRFIFEYS 354
T+E ++++ LQ+ ++E Q + + + L + K RE+N +K AK + E
Sbjct: 302 MTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKDREMN----RVKKLAKNILDE-- 355
Query: 355 CGINRENQQFKKELLQLIEQ 374
E ++F + L ++Q
Sbjct: 356 ---RTEVERFFLDALHQVKQ 372
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 56.6 bits (135), Expect = 4e-08
Identities = 68/264 (25%), Positives = 124/264 (46%), Gaps = 23/264 (8%)
Query: 154 RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT 213
RLK AE+ ++ Q ++ + L E E +E L Q R + + +E
Sbjct: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQW 784
Query: 214 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 273
++ Y + + E ER Q++A + AE L+ Q E S+L R L+A +
Sbjct: 785 ALQQQRQRLYSEVAEERERLGQQAARQRAE----LEELRQQLEESSSALTRALRA--EFE 838
Query: 274 ILKEKQEK----EIQTLQEETK-KVQAETASKTREVQAQLL-QEKRLLEKQLSEPDRRLL 327
+E+QE+ E+ TL+++ + + QA A +TR+ +A LL +E+ L E+ D+ +
Sbjct: 839 KGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE 898
Query: 328 GKRKRRELNM---KAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSH 384
R E +M K ++ K A R I R +++ EL +L + +KL S
Sbjct: 899 LVIHRLEADMALAKEESEKAAESR--------IKRLRDKYEAELSELEQSERKLQERCSE 950
Query: 385 LENRKQQLQQEQWYLESLIQARQR 408
L+ + + + E L+ L++ ++R
Sbjct: 951 LKGQLGEAEGENLRLQGLVRQKER 974
Score = 46.2 bits (108), Expect = 6e-05
Identities = 46/206 (22%), Positives = 89/206 (43%), Gaps = 29/206 (14%)
Query: 230 IERRRQESASRYAEQISVLKTALL-QKENIQSSLKRKL----QAMRDIAILKEKQEKEIQ 284
+ ++R +A R E L L Q+E+ +++++R L Q + D +L EK E +
Sbjct: 591 LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVA 650
Query: 285 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKL 344
L++E ++ A + + ++ + K L+ + + ++ ++ + + L+
Sbjct: 651 ELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEP 710
Query: 345 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQS-----HLENRK---------- 389
++ I + + R + ELLQ E+A + Q+ LE K
Sbjct: 711 EIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERER 770
Query: 390 ------QQLQQEQWYLESLIQARQRL 409
Q L+QEQW L+ Q RQRL
Sbjct: 771 ARQRFQQHLEQEQWALQ---QQRQRL 793
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/258 (21%), Positives = 112/258 (43%), Gaps = 42/258 (16%)
Query: 155 LKEKIVAEMTDLN-KHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT 213
L ++ +A+ DL + +K+ + + L+ RE H E + + + F++ L + +
Sbjct: 586 LLQRALAQQRDLTARRVKETEKALSRQLQRQRE-HYEATIQR--HLAFIDQLIEDKKVLS 642
Query: 214 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 273
E+ E V E+++ Q R A+ Q+ + +++ ++++
Sbjct: 643 EKCEAV-------VAELKQEDQRCTERVAQA--------------QAQHELEIKKLKELM 681
Query: 274 ILKEKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKR 332
EK +E + + E+TKK++ T E+Q + + K+ + + S + LL +R
Sbjct: 682 SATEKARRE-KWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER 740
Query: 333 RELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQL 392
QA +L RE + +KE L E+ + Q HLE + L
Sbjct: 741 ASQRCLRQAEEL--------------REQLEREKEALGQQERERARQRFQQHLEQEQWAL 786
Query: 393 QQEQWYLES-LIQARQRL 409
QQ++ L S + + R+RL
Sbjct: 787 QQQRQRLYSEVAEERERL 804
Score = 35.8 bits (81), Expect = 0.079
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 7/165 (4%)
Query: 177 RKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVW---NSYLQKSGEIERR 233
R+Q L E R+K + +R + K E ++ + Y + E+E+
Sbjct: 881 REQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQS 940
Query: 234 RQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE----IQTLQEE 289
++ R +E L A + +Q +++K +A+ D + E+ E Q +++E
Sbjct: 941 ERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQE 1000
Query: 290 TKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 334
+ A + +TR+ +A+L + + +L E RR+ R+E
Sbjct: 1001 FEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1045
Score = 28.9 bits (63), Expect = 9.7
Identities = 35/192 (18%), Positives = 84/192 (43%), Gaps = 8/192 (4%)
Query: 78 RELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHS 137
+E + L + +EL+ ++ + + + L + L E + +RL Y +
Sbjct: 873 KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEA 932
Query: 138 LINNFVKPE-KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 196
++ + E KL + + LK ++ E N ++ Q+++ LE+++ ++ + + +
Sbjct: 933 ELSELEQSERKLQERCSELKGQL-GEAEGENLRLQGLVRQKERALEDAQAVNEQ---LSS 988
Query: 197 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKE 256
E + + + E+ E+ + ++ R+Q ++ KTAL +KE
Sbjct: 989 ERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRV---KTALARKE 1045
Query: 257 NIQSSLKRKLQA 268
SSL+ + +A
Sbjct: 1046 EAVSSLRTQHEA 1057
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 56.2 bits (134), Expect = 6e-08
Identities = 59/282 (20%), Positives = 123/282 (43%), Gaps = 38/282 (13%)
Query: 141 NFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRF 200
N + E+ +K +LK K A +TDL + +++ + QR++L + R+L +
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS--------- 1057
Query: 201 FLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQS 260
T+ +++ E ++ +Q + + E Q + +R E+ + AL + ++S
Sbjct: 1058 -----TDLSDQIAELQAQIAELKMQLAKK-EEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 261 SLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS 320
+ + + + K EK+ + L EE + ++ E AQ QE R
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ--QELR------- 1162
Query: 321 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 380
++ +E+N+ + L+ AK + I Q+ + + +L EQ ++
Sbjct: 1163 --------SKREQEVNILKKTLEEEAK----THEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 381 TQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDV 422
+++LE KQ L+ E+ L + + + LQG + R+ V
Sbjct: 1211 VKANLEKAKQTLENERGELAN--EVKVLLQGKGDSEHKRKKV 1250
Score = 55.1 bits (131), Expect = 1e-07
Identities = 62/279 (22%), Positives = 119/279 (42%), Gaps = 30/279 (10%)
Query: 143 VKPEKLTKVETRLKEKIV---AEMTDLNKHIKQAQTQRKQLLEE----SRELHREKLLVQ 195
VK + +V T L +K+ E+ ++ + Q+ ++ +L ++ +L + L+Q
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 196 AENRFFLEYLT---------NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQIS 246
ENR L T N E E+ E+ ++ ++ + + + + + +
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 247 VLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKV------QAETA-- 298
L+TA K +Q L+ Q + +K EK LQ+E + Q ++A
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 299 --SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCG 356
K ++ L +EK + K E DR + + RE KA +L A + + E
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDR---AEAEAREKETKALSLARALEEAM-EQKAE 1494
Query: 357 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 395
+ R N+QF+ E+ L+ + + LE K+ L+Q+
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Score = 43.9 bits (102), Expect = 3e-04
Identities = 78/372 (20%), Positives = 164/372 (44%), Gaps = 48/372 (12%)
Query: 74 TNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSC-----RDLQDE--CLDSRFAE 126
+ KL+++ + RE Q + + + H+L ++ LH+ + ++D CL++ E
Sbjct: 1328 STKLKQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-EE 1385
Query: 127 GPRRLLPPYHSLINNFVKP----EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLE 182
R+L L + +KL K +TRL++++ + DL+ + A K+ +
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 183 ESRELHREKLLVQ--AENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASR 240
+ L EK + AE R E + E + +++ E+ER ++ +
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 241 YAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK--------- 291
+ +S K+++ S+ ++ R + E+Q +E++T EE +
Sbjct: 1506 MEDLMS-------SKDDVGKSVHELEKSKRAL----EQQVEEMKTQLEELEDELQATEDA 1554
Query: 292 ------KVQAETASKTREVQA---QLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA-QA 341
+QA A R++Q Q ++K+ L +Q+ E + L +RK+R + + A +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK 1614
Query: 342 LKLAAKRFIFEY-SCGINREN--QQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWY 398
L++ K S NR+ +Q +K Q+ + ++L T++ E Q ++ +
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 399 LESLIQARQRLQ 410
L+S+ +LQ
Sbjct: 1675 LKSMEAEMIQLQ 1686
Score = 42.7 bits (99), Expect = 6e-04
Identities = 53/270 (19%), Positives = 115/270 (42%), Gaps = 35/270 (12%)
Query: 166 LNKHIKQAQTQRKQLLEESRELHREKLLV----QAENRFFLEYLTNKTEEYTEQPEKVWN 221
L + +++ +TQ ++L +E + KL + QA F L + E+ E+ +++
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 222 SYLQKSGEIERRRQESASRYAEQISV---LKT--------------ALLQKENIQSSLKR 264
+ E+E R++ + A + + LK A+ Q +Q+ +K
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 265 KLQAMRDIAILKEK-------QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEK 317
++ + D +E+ EK++++++ E ++Q E A+ R + + L ++
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 318 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQK 377
+ + L ++R L + L+ + E N + KK LQ+ +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELE----EEQGNTELINDRLKKANLQIDQINTD 1765
Query: 378 LTATQSHL---ENRKQQLQQEQWYLESLIQ 404
L +SH EN +QQL+++ L+ +Q
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Score = 37.0 bits (84), Expect = 0.036
Identities = 56/251 (22%), Positives = 111/251 (44%), Gaps = 37/251 (14%)
Query: 168 KHIKQAQTQRKQLLEESRELH--REKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 225
K + Q Q ++++ + EL REK L AENR TE T Q + + LQ
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRL--------TEMETLQSQLMAEK-LQ 884
Query: 226 KSGEIERRRQESASRYAEQISVLKTALLQK-----ENIQSSLKRKLQAMRDIAILKEKQE 280
+++ + A AE++ TA Q+ ++++ ++ + + + + K+K +
Sbjct: 885 LQEQLQAETELCAE--AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 281 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 340
+ IQ L+E+ ++ ++ E + K+L E+Q+ D+ N K
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ-----------NCKLA 991
Query: 341 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 400
K + I E++ + E ++ K L + K A + LE R L++E+ +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSK----SLAKLKNKHEAMITDLEER---LRREEKQRQ 1044
Query: 401 SLIQARQRLQG 411
L + R++L+G
Sbjct: 1045 ELEKTRRKLEG 1055
Score = 35.0 bits (79), Expect = 0.14
Identities = 64/278 (23%), Positives = 114/278 (41%), Gaps = 48/278 (17%)
Query: 88 RELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRFAEGPRRLLPPYHSLINNFVKPEK 147
R+LQ Q+ D + EL R ++E L ++ E ++L +I E+
Sbjct: 1641 RKLQAQMKDC--------MRELDDTRASREEIL-AQAKENEKKLKSMEAEMIQ---LQEE 1688
Query: 148 LTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTN 207
L E R K + E +L I + + LEE R L E + Q E LE
Sbjct: 1689 LAAAE-RAKRQAQQERDELADEIANSSGKGALALEEKRRL--EARIAQLEEE--LEEEQG 1743
Query: 208 KTEEYTEQPEK-------------VWNSYLQKSG----EIERRRQESA-----------S 239
TE ++ +K + S+ QK+ ++ER+ +E S
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 240 RYAEQISVLKTALLQ-KENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 298
+Y I+ L+ + Q +E + + K + A + + EK+ K++ ++ ++ +
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVR-RTEKKLKDVLLQVDDERRNAEQYK 1862
Query: 299 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK-RREL 335
+ + +L Q KR LE+ E R +RK +REL
Sbjct: 1863 DQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,040,762
Number of Sequences: 37866
Number of extensions: 743883
Number of successful extensions: 8512
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 901
Number of HSP's that attempted gapping in prelim test: 4419
Number of HSP's gapped (non-prelim): 3020
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.