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Search of human proteins with 218083716
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo
sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo s... 868 0.0
gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo s... 857 0.0
gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo sa... 537 e-153
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 70 4e-12
gi|242332545 coiled-coil domain containing 121-like [Homo sapiens] 69 7e-12
gi|16262452 cingulin [Homo sapiens] 69 7e-12
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 66 7e-11
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 66 7e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 65 1e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 65 1e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 65 1e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 65 1e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 65 1e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 65 1e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 65 1e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 65 1e-10
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 65 1e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 64 3e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 63 6e-10
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 62 8e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 62 1e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 62 1e-09
gi|148746195 trichohyalin [Homo sapiens] 59 7e-09
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 59 7e-09
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 59 1e-08
gi|221139761 zinc finger protein 853 [Homo sapiens] 58 2e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 58 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 3e-08
gi|50083279 centrosome protein 4 [Homo sapiens] 57 3e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 57 3e-08
>gi|218083716 coiled-coil domain containing 121 isoform 1 [Homo
sapiens]
Length = 442
Score = 868 bits (2242), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL
Sbjct: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
Query: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL
Sbjct: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
Query: 121 DSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 180
DSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK
Sbjct: 121 DSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 180
Query: 181 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA
Sbjct: 181 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
Query: 241 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 300
SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA
Sbjct: 241 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 300
Query: 301 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN
Sbjct: 301 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
Query: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 420
RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN
Sbjct: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 420
Query: 421 RQDVPKTTPSLPQGTKSRINPK 442
RQDVPKTTPSLPQGTKSRINPK
Sbjct: 421 RQDVPKTTPSLPQGTKSRINPK 442
>gi|218083720 coiled-coil domain containing 121 isoform 2 [Homo
sapiens]
Length = 440
Score = 857 bits (2215), Expect = 0.0
Identities = 440/442 (99%), Positives = 440/442 (99%), Gaps = 2/442 (0%)
Query: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL
Sbjct: 1 MGSRGQGSHSKKTRSMPVILSPQRTGSGATGGPAARAYSVAEAVKQFRAGPAGTGAGCSL 60
Query: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL
Sbjct: 61 QGCWAAPRPFEHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECL 120
Query: 121 DSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 180
DSR FAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK
Sbjct: 121 DSR--FAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRK 178
Query: 181 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA
Sbjct: 179 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 238
Query: 241 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 300
SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA
Sbjct: 239 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 298
Query: 301 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN
Sbjct: 299 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 358
Query: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 420
RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN
Sbjct: 359 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 418
Query: 421 RQDVPKTTPSLPQGTKSRINPK 442
RQDVPKTTPSLPQGTKSRINPK
Sbjct: 419 RQDVPKTTPSLPQGTKSRINPK 440
>gi|39979626 coiled-coil domain containing 121 isoform 3 [Homo
sapiens]
Length = 278
Score = 537 bits (1384), Expect = e-153
Identities = 278/278 (100%), Positives = 278/278 (100%)
Query: 165 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 224
MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS
Sbjct: 1 MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 60
Query: 225 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 284
YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE
Sbjct: 61 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE 120
Query: 285 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 344
IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL
Sbjct: 121 IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQAL 180
Query: 345 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 404
KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL
Sbjct: 181 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 240
Query: 405 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 442
IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK
Sbjct: 241 IQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK 278
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 70.1 bits (170), Expect = 4e-12
Identities = 77/279 (27%), Positives = 145/279 (51%), Gaps = 22/279 (7%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN-RFFLEY 206
E+L ++E ++K+ +AE T L ++ A K L+E+ L ++K +V AE R E
Sbjct: 325 ERLQELE-KIKDLHMAEKTKLITQLRDA----KNLIEQ---LEQDKGMVIAETKRQMHET 376
Query: 207 LTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKR 266
L K EE + ++ + GE R ++E + R A L+ AL + + + +R
Sbjct: 377 LEMKEEEIAQLRSRI--KQMTTQGEELREQKEKSERAA--FEELEKALSTAQKTEEA-RR 431
Query: 267 KLQAMRD--IAILKEKQEKEIQTLQEETKKVQAETAS-KTREVQAQLLQEKRLLEKQLSE 323
KL+A D I +++ E+E +LQ+E +V+ E + + Q+ + ++L EK+L+
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491
Query: 324 PDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTAT 383
++ L K + RE + Q +K+A ++ EY I++E +Q + L+ +E +K T
Sbjct: 492 KEQELTKKLQTREREFQEQ-MKVALEKSQSEY-LKISQEKEQQESLALEELELQKKAILT 549
Query: 384 QSHLENRKQQLQQE-QWYLESLIQARQRLQGSHNQCLNR 421
+S EN+ + LQQE + Y +++ L+ S + N+
Sbjct: 550 ES--ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Score = 57.4 bits (137), Expect = 3e-08
Identities = 63/307 (20%), Positives = 140/307 (45%), Gaps = 32/307 (10%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAEN----RFF 203
EK+ + K K++ ++ D I+Q + + ++ E++ E L ++ E R
Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
Query: 204 LEYLTNKTEEYTEQPEKVWNSYLQK-------SGEIERRRQESASRYAEQISVL-KTALL 255
++ +T + EE EQ EK + ++ + + E R++ + EQI + KT+
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 256 QKENIQSSLKRKLQAMRDIAILK-EKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEK 314
++ ++Q L R Q + D+ E+Q ++Q L E+ + + +K + + + QE+
Sbjct: 451 ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 315 RLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS---CGINRENQQFKKELL 371
+ + S+ + + + K ++ ++ + L+L K + E + +E + ++ +L
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 372 QL---IEQAQKLTATQS-----HLENRKQQ--------LQQEQWYLESLIQARQRLQGSH 415
+L +E++ + QS HLE K + +++ + LESL + L
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630
Query: 416 NQCLNRQ 422
Q L +Q
Sbjct: 631 LQVLKQQ 637
Score = 51.2 bits (121), Expect = 2e-06
Identities = 82/374 (21%), Positives = 153/374 (40%), Gaps = 52/374 (13%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGP 130
E K E+S+L+ +L Q+ ++ SL+ + + S R DE +C+ +
Sbjct: 1360 EELKEKKVEISSLSKQLTDLNVQLQNSI--SLSEKEAAISSLRKQYDE---EKCELLDQV 1414
Query: 131 RRLLPPYHSLINNFVKPEKLTKVE---------TRLKEKIVAEMTDLNKHIKQAQTQ--- 178
+ L S + + EK++ +E + K+K + T +K+ Q Q
Sbjct: 1415 QDL-----SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469
Query: 179 -RKQLLEESRELHREKLLVQAENRFF------LEYLTNKTEEYTEQPEKVWNSYLQKSGE 231
K+ E+ +++ K + +N+ F +E +K E+ E S + E
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
Query: 232 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKE----IQT 287
+E + VLK QK+ L +KLQ +++ K+ + KE I T
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 347
L+ + ++AE +K +E++ L K E + + L R E K LK
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKS------KEEELKALEDRLESESAAKLAELKRK 1643
Query: 348 AKRFIFEYSCGINRENQQFKKELLQLIE--QAQKLTATQSHLENRKQQLQQEQWYLESLI 405
A++ I KK+LL +E + Q T+SHL +LQ+ + + L
Sbjct: 1644 AEQKI-----------AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 406 QARQRLQGSHNQCL 419
+ + ++ S ++ L
Sbjct: 1693 EKLKSVESSQSETL 1706
Score = 47.4 bits (111), Expect = 3e-05
Identities = 66/337 (19%), Positives = 142/337 (42%), Gaps = 22/337 (6%)
Query: 113 RDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHI 172
+DL + + + + L Y S + + K ++ TK KE ++ +M + K
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENR-FFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 231
+ TQ+ E+S + E+ + +N+ +E + K +E E +K L + +
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK---KLLDQEAK 980
Query: 232 IERRRQESASRYAEQ-----ISVLKTALLQKENIQSSLKR-KLQAMRDIAILKEKQEKEI 285
+++ + +A +++ +L+ A I ++ R + I L E +E+
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040
Query: 286 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRR-LLGKRKRRELNMKAQAL 344
+ +K + A + +E+ LQEK E++++E ++ LL ++ E+N + L
Sbjct: 1041 NDVISIWEKKLNQQAEELQEIHEIQLQEK---EQEVAELKQKILLFGCEKEEMNKEITWL 1097
Query: 345 KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE----NRKQQLQQEQWY 400
K + +N +Q K++ + AQ T ++HLE + + L++ +
Sbjct: 1098 KEEG----VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 401 LESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKS 437
E L++ + + + KTT Q KS
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190
Score = 47.0 bits (110), Expect = 3e-05
Identities = 66/315 (20%), Positives = 142/315 (45%), Gaps = 40/315 (12%)
Query: 146 KPEKLTK-VETRLKE-----KIVAEMTDLNK-HIKQAQTQRKQLLEESRELHREKLLVQA 198
K ++LTK ++TR +E K+ E + I Q + Q++ L E EL ++ +L ++
Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551
Query: 199 ENRFFLEYLTNKTEEYTEQP-------EKVWNSYLQKSGEIERRRQESASRYAEQISVL- 250
EN+ L L + E Y + EK +S ++ + +++ ++I+V+
Sbjct: 552 ENK--LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV 609
Query: 251 ---KTALLQKENIQSSL-KRKLQAMR-----DIAILKEKQEKEIQTLQEETKKVQAETAS 301
KT L ++ Q +L KLQ ++ ++ L+EK E+E +TL ++ + +
Sbjct: 610 EKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIE 669
Query: 302 KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR 361
+ E + L K+ + LS +L + R +L + LK + E ++
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVL--KARHKLEEELSVLKDQTDKMKQELEAKMDE 727
Query: 362 ENQQFKKELLQLIEQAQ------------KLTATQSHLENRKQQLQQEQWYLESLIQARQ 409
+ ++++ +I++ + ++ + L+ R + L++ Q ++E+L +
Sbjct: 728 QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIK 787
Query: 410 RLQGSHNQCLNRQDV 424
R +G Q + DV
Sbjct: 788 RSEGELQQASAKLDV 802
Score = 40.8 bits (94), Expect = 0.002
Identities = 62/263 (23%), Positives = 120/263 (45%), Gaps = 23/263 (8%)
Query: 150 LTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTN 209
L + ET+LK + DLNK +K+ ++QL+E K+L + + R E LT+
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE-------LKMLAEEDKRKVSE-LTS 1176
Query: 210 KTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 269
K + E+ + + +S+ + + +E + E + +E++++ +K ++ L+ K
Sbjct: 1177 KLKTTDEEFQSLKSSHEKSNKSLEDKSLE-FKKLSEELAIQLDICCKK--TEALLEAKTN 1233
Query: 270 AMRDIAILKEKQ-EKEIQTLQEETKKVQAETASKT---REVQAQLLQ---EKRLLEKQLS 322
+ +I+ K I Q T KV+ KT E++AQL Q E+ L
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 323 EPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQK-LT 381
+ +L K + + +MKA L ++ + G QQ E I Q +K L+
Sbjct: 1294 QATHQLEEKENQIK-SMKADIESLVTEKEALQKEGG---NQQQAASEKESCITQLKKELS 1349
Query: 382 ATQSHLENRKQQLQQEQWYLESL 404
+ + K++L++++ + SL
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSL 1372
Score = 40.0 bits (92), Expect = 0.004
Identities = 50/247 (20%), Positives = 115/247 (46%), Gaps = 26/247 (10%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K + K+ + D+ K +++ + + L ++ +EL + + +R +E LT+K
Sbjct: 1822 KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY 1881
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ Q + + + + +E +E + + Q +L Q +++ L A
Sbjct: 1882 EKL--QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG---AE 1936
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R+ K+K KEI LQ++ + ++ E QE +L+K+ + +R K
Sbjct: 1937 RE----KQKLGKEIVRLQKDLRMLRKEHQ-----------QELEILKKEYDQ-EREEKIK 1980
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTA--TQSHLEN 389
+++ +L +K + K+ + E++ + ++ Q+ + + + I +AQ++ A +SH E
Sbjct: 1981 QEQEDLELKHNS---TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEE 2037
Query: 390 RKQQLQQ 396
Q L++
Sbjct: 2038 TNQLLKK 2044
Score = 34.7 bits (78), Expect = 0.18
Identities = 69/319 (21%), Positives = 124/319 (38%), Gaps = 58/319 (18%)
Query: 146 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQ-RKQLL---EESRELHRE--------- 192
K E+L +E RL+ + A++ +L + +Q +KQLL EE E +++
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 193 --KLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS----RYAEQ 246
KL + LE E + V S + E+ +S Y E+
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 247 ISVLKTALLQK------------ENIQSSLKRKLQAMRDIAILKEKQEKE---------- 284
ISVL+ L +K E + S + + Q + L+ + K+
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL 1797
Query: 285 IQTLQEETKKVQAETASKT-REVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 343
+ L+E+ KK A +E +Q K+ LE + + L +E + Q
Sbjct: 1798 QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL------QEKELTCQI 1851
Query: 344 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQS-HLENRKQQLQQEQWYLE 402
L+ K E + R+ + + E+ +L + +KL A Q N+ +L +E +
Sbjct: 1852 LEQKIK----ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907
Query: 403 S---LIQAR--QRLQGSHN 416
S L+Q + ++ HN
Sbjct: 1908 SKSHLVQPKLLSNMEAQHN 1926
Score = 32.0 bits (71), Expect = 1.2
Identities = 46/226 (20%), Positives = 99/226 (43%), Gaps = 49/226 (21%)
Query: 226 LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ---------------- 269
+++ + +R +E+ + EQ ++L + +KE +Q L +LQ
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLLTS---EKEALQEQLDERLQELEKIKDLHMAEKTKL 344
Query: 270 --AMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------LQEK 314
+RD L E+ E++ + ETK+ ET E AQL L+E+
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 315 R---------LLEKQLSEPDRRLLGKRK-RRELNMKAQALKLAAKRFIFEYSCGINRENQ 364
+ LEK LS + +RK + E++ + + ++ ++ E + +E
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE----EERISLQQELS 460
Query: 365 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQR 410
+ K+E++ +++++ + + + K+ ++EQ L +Q R+R
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ-ELTKKLQTRER 505
Score = 31.2 bits (69), Expect = 2.0
Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 16/131 (12%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSE-LHSCRDLQDECLDSRCKFAEG 129
E +L+ STL RE TQ+ L +T+ E ++ ++++ E L+S E
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQ-KEQELEMTIKETINKAQEVEAELLESH---QEE 2037
Query: 130 PRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESREL 189
+LL K + L + R +E + A ++ ++ QTQ LEE ++
Sbjct: 2038 TNQLLKKIAE------KDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ----LEELQKK 2087
Query: 190 HREKLLVQAEN 200
+++K L Q EN
Sbjct: 2088 YQQK-LEQEEN 2097
>gi|242332545 coiled-coil domain containing 121-like [Homo sapiens]
Length = 439
Score = 69.3 bits (168), Expect = 7e-12
Identities = 51/230 (22%), Positives = 110/230 (47%), Gaps = 12/230 (5%)
Query: 168 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
L++ + + Q+L E+ L RE L ++ ENR + Y++ + + + ++
Sbjct: 41 LSEQLDTCEESVDQVLRENAFLDREALRLREENRLYASYVSARAQRCAKAIVRLDEQNRV 100
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+I +R E AS Y + ++ LL+ E + + +++Q ++ +L+ +Q I+
Sbjct: 101 DLAQIHWQRAELASLYHGREDGVRAQLLEMEARAAQMAQQVQELQPYKVLQLEQLARIRA 160
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 347
L+ E ++ E V+ + L++K E++ + + L +R RE
Sbjct: 161 LERELLHMRVEHTQLLHRVKRRFLEDKAAFEREARQRVQSL-ARRAERE----------- 208
Query: 348 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
A R + ++ I +N + ++ELL L+ + Q L T+ L +++QL +E
Sbjct: 209 AVRALVAHTQAIKADNGRLRQELLLLLRRTQLLHHTRRQLLEQREQLHRE 258
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 69.3 bits (168), Expect = 7e-12
Identities = 78/351 (22%), Positives = 151/351 (43%), Gaps = 64/351 (18%)
Query: 104 VTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVA 163
V L +L R+L +E L+ + + E R ++ +LT ++ LKE++ +
Sbjct: 464 VLLKDLLETRELLEEVLEGKQRVEEQLR-------------LRERELTALKGALKEEVAS 510
Query: 164 EMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV-- 221
++ +Q Q +QL ++ ++ +++AE + + E E E+
Sbjct: 511 RDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGH 570
Query: 222 WNSYLQKSGE-----------IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQA 270
W S QK+ E + ++E E+I VL+ L Q +
Sbjct: 571 WQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA-------RASAGD 623
Query: 271 MRDIAILKEKQEKEIQTLQEETKKVQAETAS-------KTREVQAQL------------L 311
R + +LK KE+ QEE K++QAE S + RE++ QL L
Sbjct: 624 TRQVEVLK----KELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSC-GINRENQQFKKEL 370
+E+ L ++ + R+ + + ++ +A+A L +R E + EN +F++ +
Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
Query: 371 LQLIEQAQKL-------TATQSHLENRKQQLQQEQWYLESLIQARQRLQGS 414
L L +Q ++ A ++ L ++ Q+L+ E+ LE + A Q +GS
Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGS 790
Score = 49.7 bits (117), Expect = 5e-06
Identities = 59/242 (24%), Positives = 104/242 (42%), Gaps = 30/242 (12%)
Query: 204 LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+E L K +E ++ +K+ S + ++E + +E SR E + K Q +
Sbjct: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEE-CSRLQELLERRKGEAQQSNKELQN 426
Query: 264 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASK---------TREVQAQLLQEK 314
+KR L D L+ E ++ LQ + K VQ +K TRE+ ++L+ K
Sbjct: 427 MKRLLDQGED---LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK 483
Query: 315 RLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLI 374
+ +E+QL + + REL ALK A K + + QQ++++ QL
Sbjct: 484 QRVEEQL---------RLRERELT----ALKGALKEEVASRDQEVEHVRQQYQRDTEQLR 530
Query: 375 EQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCL---NRQDVPKTTPSL 431
Q T + LE +Q++ L+ ++ G H Q + N++D+ T L
Sbjct: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETG-HWQSMFQKNKEDLRATKQEL 589
Query: 432 PQ 433
Q
Sbjct: 590 LQ 591
Score = 43.1 bits (100), Expect = 5e-04
Identities = 52/249 (20%), Positives = 109/249 (43%), Gaps = 30/249 (12%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYL 207
E+ ++ R +++ E+ + + KQA Q + LE+ +E R + + A+
Sbjct: 841 EEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE-VADAQ-------- 891
Query: 208 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 267
+ +++ + EK + EI+R RQ + AE+ TA L KE + L+
Sbjct: 892 -RQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAER----DTARLDKELLAQRLQGL 946
Query: 268 LQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRR 327
Q + ++ + ++++ L+E+ +++ E + V+ L Q+ +
Sbjct: 947 EQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVEL-LTDRVNRGRDQVDQLRTE 1005
Query: 328 LLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHL 387
L+ +R R+ +++ + L R+N+ K L E QK +A+ S L
Sbjct: 1006 LMQERSARQ-DLECDKISL-------------ERQNKDLKTRLAS-SEGFQKPSASLSQL 1050
Query: 388 ENRKQQLQQ 396
E++ Q LQ+
Sbjct: 1051 ESQNQLLQE 1059
Score = 41.2 bits (95), Expect = 0.002
Identities = 59/279 (21%), Positives = 123/279 (44%), Gaps = 50/279 (17%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
+TR E + E+ + +K+ Q +R+ +E HR++ L + L ++ E
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQS--QEVAGRHRDREL--EKQLAVLRVEADRGRE 678
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASR-----------YAEQISVLKTALLQKENIQS 262
EQ N LQK+ + R+ E AS+ ++ + ++T L + +
Sbjct: 679 LEEQ-----NLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEND 733
Query: 263 SLKRKL----QAMRDIAILKEKQEKEIQTLQEETKKVQAE------TASKTREVQAQLLQ 312
+R++ Q +++ L + E L+++ ++++AE + ++E + L
Sbjct: 734 EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAA 793
Query: 313 EKRLLEKQLSEPDRRL--LGKR------------KRRELNMKAQALKLAAKRFIFEYSCG 358
KR LE +L E R L LG+ K+RE+ + +A KR +
Sbjct: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDR 853
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+N+E ++ ++ Q ++Q Q+ LE+ K++ ++E
Sbjct: 854 LNKELEKIGEDSKQALQQ------LQAQLEDYKEKARRE 886
Score = 35.8 bits (81), Expect = 0.080
Identities = 62/276 (22%), Positives = 111/276 (40%), Gaps = 41/276 (14%)
Query: 156 RLKEKIVAEMT--DLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
RL++ + A D + K+ QR Q LE+ E K Q + L+ L K
Sbjct: 917 RLRQALQASQAERDTARLDKELLAQRLQGLEQEAE---NKKRSQDDRARQLKGLEEKVSR 973
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK-RKLQAMR 272
+ ++ N+ + + R R +Q+ L+T L+Q+ + + L+ K+ R
Sbjct: 974 LETELDEEKNTVELLTDRVNRGR--------DQVDQLRTELMQERSARQDLECDKISLER 1025
Query: 273 DIAILKEKQ----------------EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 316
LK + E + Q LQE ++QAE KT E+++
Sbjct: 1026 QNKDLKTRLASSEGFQKPSASLSQLESQNQLLQE---RLQAEEREKTVLQSTNRKLERKV 1082
Query: 317 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ 376
E + D R ++ +L+++ +AL KR + E I R + KK ++ EQ
Sbjct: 1083 KELSIQIEDERQHVNDQKDQLSLRVKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQ 1138
Query: 377 AQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 412
+ L+ R + L+++ W S A L+
Sbjct: 1139 HE----VNEQLQARIKSLEKDSWRKASRSAAESALK 1170
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 65.9 bits (159), Expect = 7e-11
Identities = 87/357 (24%), Positives = 154/357 (43%), Gaps = 46/357 (12%)
Query: 116 QDECLDSRCKFAEGPRRLLPPY--HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIK 173
Q+E S C+ A RRL +L+N V T+V LK+ + E + KHIK
Sbjct: 184 QEEDRSSSCREAVLQRRLQQTIKERALLNAHV-----TQVTESLKQ-VQLERDEYAKHIK 237
Query: 174 QAQTQRKQLL------------EESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV 221
+ + ++ + E+ R++HR +Q R E E + P V
Sbjct: 238 GERARWQERMWKMSVEARTLKEEKKRDIHR----IQELERSLSELKNQMAEPPSLAPPAV 293
Query: 222 WNSYLQKSGEIERRRQE---------SASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 272
+ Q E + RQE S + +S+L Q+ Q + R+ +A R
Sbjct: 294 TSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQR 353
Query: 273 -----DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL--EKQLSEPD 325
+ E+ ++ +TLQE+ ++++ + ++ + +E+RL EK+L + +
Sbjct: 354 VREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQE 413
Query: 326 RRLLGKRKRRELNMKAQALKLAAK--RFIFEYSCGINRENQQFKKELLQLIEQAQKLTAT 383
RL K +R + + AL K + + E C N + KK LQL +Q ++L
Sbjct: 414 ERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNE-KKSALQLEQQVKELQEK 472
Query: 384 --QSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSR 438
+ HLE Q+ QQ + L SL+ G + ++ P+ TP++P+ +SR
Sbjct: 473 LDEEHLEAASQRNQQLETQL-SLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESR 528
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 65.9 bits (159), Expect = 7e-11
Identities = 87/357 (24%), Positives = 154/357 (43%), Gaps = 46/357 (12%)
Query: 116 QDECLDSRCKFAEGPRRLLPPY--HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIK 173
Q+E S C+ A RRL +L+N V T+V LK+ + E + KHIK
Sbjct: 184 QEEDRSSSCREAVLQRRLQQTIKERALLNAHV-----TQVTESLKQ-VQLERDEYAKHIK 237
Query: 174 QAQTQRKQLL------------EESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV 221
+ + ++ + E+ R++HR +Q R E E + P V
Sbjct: 238 GERARWQERMWKMSVEARTLKEEKKRDIHR----IQELERSLSELKNQMAEPPSLAPPAV 293
Query: 222 WNSYLQKSGEIERRRQE---------SASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 272
+ Q E + RQE S + +S+L Q+ Q + R+ +A R
Sbjct: 294 TSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQR 353
Query: 273 -----DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL--EKQLSEPD 325
+ E+ ++ +TLQE+ ++++ + ++ + +E+RL EK+L + +
Sbjct: 354 VREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQE 413
Query: 326 RRLLGKRKRRELNMKAQALKLAAK--RFIFEYSCGINRENQQFKKELLQLIEQAQKLTAT 383
RL K +R + + AL K + + E C N + KK LQL +Q ++L
Sbjct: 414 ERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNE-KKSALQLEQQVKELQEK 472
Query: 384 --QSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSR 438
+ HLE Q+ QQ + L SL+ G + ++ P+ TP++P+ +SR
Sbjct: 473 LDEEHLEAASQRNQQLETQL-SLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESR 528
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2271 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2314
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2435 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2544
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1360 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1414
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1415 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2119
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE 2145
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1596
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1652
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1653 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1709
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1710 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1764 ---MEVLLASKARAE 1775
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1985 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2028
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2087 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2137 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2235
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 393 QLQQE 397
+++
Sbjct: 2296 LAEED 2300
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1694
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1041
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1222 WLQDARRRQEQIQ 1234
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2275 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2318
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2379 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2438
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2439 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2548
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2601
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1364 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1418
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1419 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1475
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1536 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1595
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2123
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQE 2149
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1600
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1656
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1657 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1713
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1714 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1768 ---MEVLLASKARAE 1779
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1989 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2032
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2091 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2141 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2120
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2239
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299
Query: 393 QLQQE 397
+++
Sbjct: 2300 LAEED 2304
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1698
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRK 1904
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1114 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1229
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 987 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1045
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1046 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1105
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1226 WLQDARRRQEQIQ 1238
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2271 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2314
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2435 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2544
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2597
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1360 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1414
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1415 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1532 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1591
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2119
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE 2145
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1596
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1652
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1653 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1709
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1710 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1764 ---MEVLLASKARAE 1775
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1985 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2028
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2087 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2137 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2116
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2235
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295
Query: 393 QLQQE 397
+++
Sbjct: 2296 LAEED 2300
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1694
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRK 1900
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1225
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1041
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1042 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1101
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1222 WLQDARRRQEQIQ 1234
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2239 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2282
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2343 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2402
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2403 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2512
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2565
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1328 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1382
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1383 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1439
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1500 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1559
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2087
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQE 2113
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1564
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1620
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1621 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1677
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1678 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1731
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1732 ---MEVLLASKARAE 1743
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1953 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 1996
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2055 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2105 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2084
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2203
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263
Query: 393 QLQQE 397
+++
Sbjct: 2264 LAEED 2268
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1662
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRK 1868
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1078 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1193
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 951 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1009
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1010 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1069
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1190 WLQDARRRQEQIQ 1202
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2408 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2451
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2512 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2571
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2572 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2625 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2681
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2734
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1497 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1551
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1552 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1608
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1669 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1728
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2256
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQE 2282
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1733
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1789
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1790 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1846
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1847 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1900
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1901 ---MEVLLASKARAE 1912
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 2122 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2165
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2224 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2274 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2253
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2372
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432
Query: 393 QLQQE 397
+++
Sbjct: 2433 LAEED 2437
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1831
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRK 2037
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1247 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1362
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 1120 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1178
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1179 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1238
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1359 WLQDARRRQEQIQ 1371
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2249 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2292
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2353 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2412
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2413 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2466 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2522
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2575
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1338 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1392
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1393 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1449
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1510 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1569
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2097
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQE 2123
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1574
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1630
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1631 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1687
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1688 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1741
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1742 ---MEVLLASKARAE 1753
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1963 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2006
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2065 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2115 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2094
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2213
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273
Query: 393 QLQQE 397
+++
Sbjct: 2274 LAEED 2278
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1672
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRK 1878
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1088 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1203
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 961 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1019
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1020 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1079
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1200 WLQDARRRQEQIQ 1212
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2257 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2300
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2361 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2420
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2421 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2474 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2530
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2583
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1346 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1400
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1401 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1457
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1458 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1518 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1577
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1996
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2105
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQE 2131
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1582
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1638
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1639 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1695
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1696 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1749
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1750 ---MEVLLASKARAE 1761
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 1971 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2014
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2073 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2123 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2102
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2221
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281
Query: 393 QLQQE 397
+++
Sbjct: 2282 LAEED 2286
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1680
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRK 1886
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1096 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1211
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1212 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 969 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1027
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1028 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1087
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1208 WLQDARRRQEQIQ 1220
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 65.1 bits (157), Expect = 1e-10
Identities = 79/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E QV + +A L+V E R L +E L + AE + E
Sbjct: 2298 EKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAEKMLK---------------E 2341
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQR---------KQLLEESR------ELHREK 193
K+ V+ + K AE+ K + Q Q +R +QL EE++ E R++
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Query: 194 LLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA 253
L + L+ + + E+ + +++ EI + + E++++++T
Sbjct: 2402 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2461
Query: 254 LLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE 313
+Q++ +R +A+ ++ E+E + LQ+E K +Q ++ Q QLLQE
Sbjct: 2462 EIQRQQSDHDAERLREAIAEL-------EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 314 KRLLEKQ-LSEPDRRLLGKRKRRELNMKAQAL---KLAAKRFIFEYSCGINRENQQFKKE 369
+ L++ LSE D L +R + K + L ++A + + E R+ QQ ++E
Sbjct: 2515 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ---QRQQQQMEQE 2571
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+L+ ++ Q E ++ Q+E LE + ++ L NQ L Q
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ 2624
Score = 59.3 bits (142), Expect = 7e-09
Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 39/296 (13%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIK-QAQTQRKQLLEESRE--LHREKLLVQAENRFFL 204
E+L +VE L+++ ++ + + K QA+ + K+L + +E + RE+ V A+ +
Sbjct: 1387 ERLAEVEAALEKQ--RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ--- 1441
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
+E +Q + + +Q + S R E+I V++ L E +
Sbjct: 1442 ---KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1498
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL-------------- 310
+ +LQA+R A E Q+++ Q E ++ + + + R+ + +L
Sbjct: 1499 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 311 ---LQEKRLLEKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIF-EYSCG 358
LQ L Q E +RRL R E ++ +L +KR F E +
Sbjct: 1559 QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ 1618
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ--EQWYLESLIQARQRLQ 412
+ R Q+ + QL E+A++ Q+ E +++ ++ E+W L++ R RLQ
Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Score = 48.9 bits (115), Expect = 9e-06
Identities = 63/266 (23%), Positives = 117/266 (43%), Gaps = 32/266 (12%)
Query: 153 VETRLKEKIVAEMTDLNKH---IKQAQTQRKQLLEESRELHR--EKLLV-QAENRFFLEY 206
+E RL + A ++L + ++ QR+Q+ EE L EK +AE L
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 207 LTNKTEEYT---EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS 263
+ + E+ EQ E Q + E ERRR+E+ R + ++ + A Q++
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037
Query: 264 LKRKLQAMRDIAILKEKQEKE----IQTLQEET-KKVQAE-------TASKTREVQAQLL 311
++R + + L+E+ E+E +Q QE K++QAE K +E+Q L
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
Query: 312 QEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELL 371
QE+ +L++ E + + E ++A+ ++R + E ++ K+
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--------EEAERLKQ--- 2146
Query: 372 QLIEQAQKLTATQSHLENRKQQLQQE 397
EQAQ Q+ E +++ +QE
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQE 2172
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/255 (20%), Positives = 118/255 (46%), Gaps = 19/255 (7%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E++ + + + ++QA+ +R + ++ + E + +AE + KT +
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRS--AEAELQSKRASFAEKTAQLERSL 1623
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK 278
++ + Q E ERR Q+ A + + + +L+ +LQA ++A
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA-EEVA--- 1679
Query: 279 EKQEKEIQTLQEETKKVQAETASKTR-EVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
Q+K + + E +K +AE ++ R + + Q ++++ L E++L E R+L ++ L
Sbjct: 1680 --QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRL 1736
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ + ++L A+ E ++ Q ++EL +L +A T + LE +++ E
Sbjct: 1737 AAEQELIRLRAETEQGE------QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1790
Query: 398 QWYLESLIQARQRLQ 412
+E L+ ++ R +
Sbjct: 1791 ---MEVLLASKARAE 1802
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 38/270 (14%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
+ E R+++ + AE ++A QRK LEE + R K V+ R L +
Sbjct: 2012 EAEERVQKSLAAE--------EEAARQRKAALEE---VERLKAKVEEARR-----LRERA 2055
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
E+ + + ++ QK + E + A + EQ L+ L Q++++ L+ + +A
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
R A +E +E +Q + E A R+V+ ++ E+ + + +
Sbjct: 2114 RRAA--EEAEEARVQA--------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ----AQKLTATQSHL 387
+ R+E +A A + A++ + E ++ KK Q + Q Q+LT + L
Sbjct: 2164 KLRKEAEQEA-ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 388 E---NRKQQLQQEQWYL--ESLIQARQRLQ 412
E ++K L +E L E+ ARQR Q
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/245 (19%), Positives = 106/245 (43%), Gaps = 7/245 (2%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E L++ + E + L++ +A+ R+ EE+ E + A++R +E + E
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVE----EAER 2143
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
+ E+ + Q E+ R+E+ A + + AL QK+ + +++ +
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 274 IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK 333
K + E+E+ TL+ + ++ + E+Q +L E +Q S+ + L R
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRV 2262
Query: 334 RRELNMKAQA-LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ E K +A ++ + I R Q+ +++ Q+ E+A +L+ +Q
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 393 QLQQE 397
+++
Sbjct: 2323 LAEED 2327
Score = 38.1 bits (87), Expect = 0.016
Identities = 58/266 (21%), Positives = 109/266 (40%), Gaps = 23/266 (8%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
K L+ ++ AE K + QA+ ++++ E R K QA + E +
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQEL 1721
Query: 212 EEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQKENIQSSLKR---- 266
E+ + E L E+ R R E+ Q+ + A LQ+E ++ KR
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 267 ----KLQAMRDIAIL-KEKQEKEIQTLQEETKKVQAETASKTREV-----QAQLLQEKRL 316
K++A ++ + K + E+E ++ E++K+ A + RE+ + + L E+
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 317 LEKQLSEPDRRLLGKRKRRELNMK------AQALKLAAKRFIFEYSCGINRENQQFKKEL 370
++QL+E D R L K A LK A+ + E R + + E
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQ 396
Q ++ ++ +E R QL++
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRK 1927
Score = 35.4 bits (80), Expect = 0.10
Identities = 37/152 (24%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 170 KHIKQAQTQRKQLLE-ESRELHREKLLVQAE-NRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+ +K+AQ L E E+ + +KL QAE + + L ++ E E++ + +
Sbjct: 1137 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ E+ER R+ A +VL +++ ++ L R+L+ R+ A + +Q
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESA---DPLGAWLQD 1252
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
+ +++QA + ++ V+ QL QE+ LLE+
Sbjct: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Score = 30.4 bits (67), Expect = 3.4
Identities = 50/253 (19%), Positives = 98/253 (38%), Gaps = 17/253 (6%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLL------EESRELHREKLLVQAENRFFLEYLTNKTE 212
++ ++E+ D+ ++ +T+ L E +RE +++ Q + + +E L
Sbjct: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPAREC-AQRIAEQQKAQAEVEGLGKGVA 1068
Query: 213 EYTEQPEKVWN-SYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAM 271
+ + EKV + R E EQ+ L L+K S + R Q
Sbjct: 1069 RLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA 1128
Query: 272 RDIAILKEKQEKEIQTLQEETKKVQAETASKTR-----EVQAQLLQEKRLLEKQLSEPDR 326
++ E+Q KE Q + +++A AS + E Q R + E
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 327 RLLGKRKRRELNMKAQALKLAAK----RFIFEYSCGINRENQQFKKELLQLIEQAQKLTA 382
RL + R++ ++ ++A + + + RE +Q ++L E A L A
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 383 TQSHLENRKQQLQ 395
R++Q+Q
Sbjct: 1249 WLQDARRRQEQIQ 1261
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 65.1 bits (157), Expect = 1e-10
Identities = 89/357 (24%), Positives = 157/357 (43%), Gaps = 46/357 (12%)
Query: 116 QDECLDSRCKFAEGPRRLLPPY--HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIK 173
Q+E S C+ A RRL +L+N V T+V LK+ + E + KHIK
Sbjct: 184 QEEDRSSSCREAVLHRRLQQTIKERALLNAHV-----TQVTESLKQ-VQLERDEYAKHIK 237
Query: 174 QAQTQRKQLL------------EESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKV 221
+ + ++ + E+ R++HR +Q R E + + P V
Sbjct: 238 GERARWQERMWKMSVEARTLKEEKKRDIHR----IQELERSLSELKNQMAKPPSLAPPAV 293
Query: 222 WNSYLQKSGEIERRRQE---------SASRYAEQISVLKTALLQKENIQSSLKRK--LQA 270
+ Q E + RQE S + +S+L Q+ Q + R+ +Q
Sbjct: 294 TSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQR 353
Query: 271 MRDIAILKEKQEK---EIQTLQEETKKVQAETASKTREVQAQLLQEKRLL--EKQLSEPD 325
+R+ L E+ E+ + +TLQE+ ++++ + ++ + +E+RL EK+L + +
Sbjct: 354 VREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQE 413
Query: 326 RRLLGKRKRRELNMKAQALKLAAK--RFIFEYSCGINRENQQFKKELLQLIEQAQKLTAT 383
RL K +R + + AL K + + E C N + KK LQL +Q ++L
Sbjct: 414 ERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNE-KKSALQLEQQVKELQEK 472
Query: 384 --QSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSR 438
+ HLE QQ QQ + L SL+ G + ++ P+ TP++P+ +SR
Sbjct: 473 LDEEHLEAASQQNQQLETQL-SLVALPGEGDGGQHLDSEEEEAPRPTPNIPEDLESR 528
Score = 38.5 bits (88), Expect = 0.012
Identities = 63/279 (22%), Positives = 125/279 (44%), Gaps = 27/279 (9%)
Query: 165 MTDLNKHIKQAQTQRKQL---LEESRELHREKLLVQAE-----NRFFLEYLTNKTEEYTE 216
++ LN++I+ + Q+KQ+ LEE+++ + E Q E N LE KT Y
Sbjct: 85 ISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLY-- 142
Query: 217 QPEKVWNSYLQKSGEIERRRQESASRYAE-QISVLKTALLQKENIQSS------LKRKL- 268
++ + ++S ++ R Q S R E + ++ + Q+E +SS L R+L
Sbjct: 143 HTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQ 202
Query: 269 QAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL 328
Q +++ A+L + + E K+VQ E + ++ + + + + K E R
Sbjct: 203 QTIKERALL----NAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVE--ART 256
Query: 329 LGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE 388
L + K+R+++ + Q L+ + + + + + QL ++A+ L LE
Sbjct: 257 LKEEKKRDIH-RIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLE 315
Query: 389 NRKQQLQQEQWYLESLI-QARQRLQGSHNQCLNRQDVPK 426
+ Q + L L + +QRLQ + L Q+V +
Sbjct: 316 GKLQSQVENNQALSLLSKEQKQRLQ-EQEEMLREQEVQR 353
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 63.9 bits (154), Expect = 3e-10
Identities = 61/273 (22%), Positives = 132/273 (48%), Gaps = 25/273 (9%)
Query: 139 SLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 198
S++ +F+K +++ + KE+ + + + ++A+ R+Q +EE + E++ ++
Sbjct: 514 SVMKSFIKRNTPLRMDPKEKER---QRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR 570
Query: 199 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALLQK 257
E R L + E + E+ QK +I+ + +++ R AE+ + K A +
Sbjct: 571 EER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM 628
Query: 258 ENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL 317
E +++ K++ +A R + +E++E+ Q L ++ K+ + E K E A+ L E+R
Sbjct: 629 EEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE--AKRLAEQREQ 686
Query: 318 EKQLSEPDRRLLGKRKRRELNMKAQALKLA------------AKRFIFEYSCGINRENQQ 365
E++ E + +++RRE + Q +LA A+R + E + + +Q
Sbjct: 687 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ 746
Query: 366 FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 398
++EL + +K Q L R+ Q +QE+
Sbjct: 747 LQREL-----EEKKKKEEQQRLAERQLQEEQEK 774
Score = 55.5 bits (132), Expect = 1e-07
Identities = 79/328 (24%), Positives = 144/328 (43%), Gaps = 45/328 (13%)
Query: 106 LSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEM 165
+SEL + L+DE L + PR P + V+P + T + T + +++
Sbjct: 457 VSELDEEQHLEDEEL-------QPPRSKTPSSPCPASKVVRPLR-TFLHTVQRNQMLMTP 508
Query: 166 TDLNKHIKQAQTQRKQLLE-ESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNS 224
T + + ++ +R L + +E R++L E L K E + +KV
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMDPKEKERQRL----------ENLRRKEEAEQLRRQKVEED 558
Query: 225 YLQKSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEK 283
++ E++ +R+E L+ L +E + Q ++K Q + A + EK EK
Sbjct: 559 KRRRLEEVKLKREER----------LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 608
Query: 284 EIQTLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE- 336
+ E K + A K EV+A+ QE +RL Q E +RR LL K+K E
Sbjct: 609 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
Query: 337 --LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQL 394
L A+A +LA +R E RE ++ ++E + + Q+ + L ++++
Sbjct: 669 ERLRKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 395 QQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+QE+ E +Q R++ + L R+
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRE 750
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/256 (21%), Positives = 118/256 (46%), Gaps = 38/256 (14%)
Query: 145 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF- 203
++ +K+ + + R E++ + + + + QA+ + +Q+ EE ++ Q E +F
Sbjct: 550 LRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK--------QIEQKFAQ 601
Query: 204 LEYLTNKTEEYTEQPEKVWN-SYLQKSGEIE-RRRQESASRYAEQISVLKTALLQKENIQ 261
++ T K +E EK + +K E+E RR+QE +R + + +E +Q
Sbjct: 602 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
Query: 262 SSLKRKLQAMRDIAILKE-----KQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 316
+ + + +R A K +QE+ Q +E+ ++ Q + RE + QL +++R
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Query: 317 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQ 376
E++ + + REL + +AL+L ++ + RE ++ KK+ E+
Sbjct: 722 REQERLQAE---------RELQEREKALRLQKEQ--------LQRELEEKKKK-----EE 759
Query: 377 AQKLTATQSHLENRKQ 392
Q+L Q E K+
Sbjct: 760 QQRLAERQLQEEQEKK 775
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 62.8 bits (151), Expect = 6e-10
Identities = 70/343 (20%), Positives = 149/343 (43%), Gaps = 44/343 (12%)
Query: 88 RELQTQVPDASAHSLAVTLSELHS---CRDLQDECL---DSRCKFAEGPRRLLPPYHSLI 141
+EL+ Q+ + + + L ++ + + L++E + D CK A+ + L
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 142 NNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENR 201
N + E+ +K +LK K A +TDL + +++ + QR++L + R+L +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS-------- 1057
Query: 202 FFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQ 261
T+ +++ E ++ +Q + + E Q + +R E+ + AL + ++
Sbjct: 1058 ------TDLSDQIAELQAQIAELKMQLAKK-EEELQAALARVEEEAAQKNMALKKIRELE 1110
Query: 262 SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQL 321
S + + + + K EK+ + L EE + ++ E AQ QE R
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ--QELR------ 1162
Query: 322 SEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 381
++ +E+N+ + L+ AK + I Q+ + + +L EQ ++
Sbjct: 1163 ---------SKREQEVNILKKTLEEEAK----THEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 382 ATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDV 424
+++LE KQ L+ E+ L + + + LQG + R+ V
Sbjct: 1210 RVKANLEKAKQTLENERGELAN--EVKVLLQGKGDSEHKRKKV 1250
Score = 55.1 bits (131), Expect = 1e-07
Identities = 62/279 (22%), Positives = 119/279 (42%), Gaps = 30/279 (10%)
Query: 145 VKPEKLTKVETRLKEKIV---AEMTDLNKHIKQAQTQRKQLLEE----SRELHREKLLVQ 197
VK + +V T L +K+ E+ ++ + Q+ ++ +L ++ +L + L+Q
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 198 AENRFFLEYLT---------NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQIS 248
ENR L T N E E+ E+ ++ ++ + + + + + +
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 249 VLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKV------QAETA-- 300
L+TA K +Q L+ Q + +K EK LQ+E + Q ++A
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 301 --SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCG 358
K ++ L +EK + K E DR + + RE KA +L A + + E
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDR---AEAEAREKETKALSLARALEEAM-EQKAE 1494
Query: 359 INRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ R N+QF+ E+ L+ + + LE K+ L+Q+
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Score = 43.1 bits (100), Expect = 5e-04
Identities = 78/374 (20%), Positives = 164/374 (43%), Gaps = 50/374 (13%)
Query: 74 TNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSC-----RDLQDE--CLDSRCKF 126
+ KL+++ + RE Q + + + H+L ++ LH+ + ++D CL++
Sbjct: 1328 STKLKQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA--- 1383
Query: 127 AEGPRRLLPPYHSLINNFVKP----EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL 182
E R+L L + +KL K +TRL++++ + DL+ + A K+
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 183 LEESRELHREKLLVQ--AENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
+ + L EK + AE R E + E + +++ E+ER ++
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 241 SRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK------- 293
+ + +S K+++ S+ ++ R + E+Q +E++T EE +
Sbjct: 1504 TEMEDLMS-------SKDDVGKSVHELEKSKRAL----EQQVEEMKTQLEELEDELQATE 1552
Query: 294 --------KVQAETASKTREVQA---QLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKA- 341
+QA A R++Q Q ++K+ L +Q+ E + L +RK+R + + A
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612
Query: 342 QALKLAAKRFIFEY-SCGINREN--QQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 398
+ L++ K S NR+ +Q +K Q+ + ++L T++ E Q ++ +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 399 WYLESLIQARQRLQ 412
L+S+ +LQ
Sbjct: 1673 KKLKSMEAEMIQLQ 1686
Score = 42.7 bits (99), Expect = 7e-04
Identities = 53/270 (19%), Positives = 115/270 (42%), Gaps = 35/270 (12%)
Query: 168 LNKHIKQAQTQRKQLLEESRELHREKLLV----QAENRFFLEYLTNKTEEYTEQPEKVWN 223
L + +++ +TQ ++L +E + KL + QA F L + E+ E+ +++
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 224 SYLQKSGEIERRRQESASRYAEQISV---LKT--------------ALLQKENIQSSLKR 266
+ E+E R++ + A + + LK A+ Q +Q+ +K
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 267 KLQAMRDIAILKEK-------QEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
++ + D +E+ EK++++++ E ++Q E A+ R + + L ++
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 320 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQK 379
+ + L ++R L + L+ + E N + KK LQ+ +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELE----EEQGNTELINDRLKKANLQIDQINTD 1765
Query: 380 LTATQSHL---ENRKQQLQQEQWYLESLIQ 406
L +SH EN +QQL+++ L+ +Q
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Score = 37.0 bits (84), Expect = 0.036
Identities = 56/251 (22%), Positives = 111/251 (44%), Gaps = 37/251 (14%)
Query: 170 KHIKQAQTQRKQLLEESRELH--REKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
K + Q Q ++++ + EL REK L AENR TE T Q + + LQ
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRL--------TEMETLQSQLMAEK-LQ 884
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQK-----ENIQSSLKRKLQAMRDIAILKEKQE 282
+++ + A AE++ TA Q+ ++++ ++ + + + + K+K +
Sbjct: 885 LQEQLQAETELCAE--AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 283 KEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQ 342
+ IQ L+E+ ++ ++ E + K+L E+Q+ D+ N K
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ-----------NCKLA 991
Query: 343 ALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 402
K + I E++ + E ++ K L + K A + LE R L++E+ +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSK----SLAKLKNKHEAMITDLEER---LRREEKQRQ 1044
Query: 403 SLIQARQRLQG 413
L + R++L+G
Sbjct: 1045 ELEKTRRKLEG 1055
Score = 33.9 bits (76), Expect = 0.30
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 49/231 (21%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHRE------KLLVQAENRFFLEYL 207
E +LK + AEM L + + A+ ++Q +E EL E K + E + LE
Sbjct: 1672 EKKLKS-MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 208 TNKTEEYTEQPE---KVWNSYLQKSG----------EIER---RRQESASRYAE-QISVL 250
+ EE E+ + ++ N L+K+ +ER ++ E+A + E Q L
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 251 KTALLQKEN-IQSSLKRKLQAMR-DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 308
K L + E ++S K + A+ IA L+E+ + E + Q K+V+ T K ++V
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR-RTEKKLKDVLL 1849
Query: 309 Q---------------------LLQEKRLLEKQLSEPDRRLLGKRK-RREL 337
Q L Q KR LE+ E R +RK +REL
Sbjct: 1850 QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 62.4 bits (150), Expect = 8e-10
Identities = 76/321 (23%), Positives = 139/321 (43%), Gaps = 39/321 (12%)
Query: 150 LTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLL------------EESRELHREKLLVQ 197
+T+V LK+ + E + KHIK + + ++ + E+ R++HR +Q
Sbjct: 215 VTQVTESLKQ-VQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHR----IQ 269
Query: 198 AENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQE---------SASRYAEQIS 248
R E E + P V + Q E + RQE S + +S
Sbjct: 270 ELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALS 329
Query: 249 VLKTALLQKENIQSSLKRKLQAMR-----DIAILKEKQEKEIQTLQEETKKVQAETASKT 303
+L Q+ Q + R+ +A R + E+ ++ +TLQE+ ++++ +
Sbjct: 330 LLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLR 389
Query: 304 REVQAQLLQEKRLL--EKQLSEPDRRLLGKRKRRELNMKAQALKLAAK--RFIFEYSCGI 359
++ + +E+RL EK+L + + RL K +R + + AL K + + E C
Sbjct: 390 KQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSF 449
Query: 360 NRENQQFKKELLQLIEQAQKLTAT--QSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 417
N + KK LQL +Q ++L + HLE Q QQ + L SL+ G +
Sbjct: 450 EDLNNE-KKSALQLEQQVKELQEKLDEEHLEAASHQNQQLETQL-SLVALPGEGDGGQHL 507
Query: 418 CLNRQDVPKTTPSLPQGTKSR 438
++ P+ TP++P+ +SR
Sbjct: 508 DSEEEEAPRPTPNIPEDLESR 528
Score = 37.4 bits (85), Expect = 0.027
Identities = 59/269 (21%), Positives = 118/269 (43%), Gaps = 37/269 (13%)
Query: 165 MTDLNKHIKQAQTQRKQL---LEESRELHREKLLVQAE-----NRFFLEYLTNKTEEYTE 216
++ LN++I+ + Q+KQ+ LEE+++ + E Q E N LE KT Y
Sbjct: 85 ISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLY-- 142
Query: 217 QPEKVWNSYLQKSGEIERRRQESASRYAE-QISVLKTALLQKENIQSSLKRKLQAMRDI- 274
++ + ++S ++ R Q S R E + ++ + Q+E +SS R+ R +
Sbjct: 143 HTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLQRWLQ 202
Query: 275 AILKEKQ--EKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKR 332
+KE+ + + E K+VQ E + ++ + R +
Sbjct: 203 QTIKERALLNAHVTQVTESLKQVQLERDEYAKHIKGE-----------------RARWQE 245
Query: 333 KRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA-QKLTATQSHLENRK 391
+ +++++A+ LK KR I + R + K ++ + A +T+ L++
Sbjct: 246 RMWKMSVEARTLKEEKKRDIHRIQ-ELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEA 304
Query: 392 QQLQQEQWYLESLIQARQRLQGSHNQCLN 420
+ L+QE LE +Q+ Q +NQ L+
Sbjct: 305 KHLRQEVEGLEGKLQS----QVENNQALS 329
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 62.0 bits (149), Expect = 1e-09
Identities = 78/353 (22%), Positives = 154/353 (43%), Gaps = 44/353 (12%)
Query: 82 TLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDE---CLDSRCKFAEGPRRLLPPYH 138
+L + EL+ Q+ A SL V S+ + +DLQ + D + E ++L
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL----- 774
Query: 139 SLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 198
+ EK TRL + +E + K Q + KQ+L++ E ++ +Q
Sbjct: 775 -------EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 199 ENRFFLEYLTNKTEEYTEQPEKV----------WNSYLQKSGEIERRRQESASRYAEQIS 248
E L N+ + + +KV ++ K ++ + S S + ++
Sbjct: 828 EE------LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 249 VLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 308
K A+L E LK +LQ + + K++KE++ E+ K+ + + +Q
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTL---KEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 309 QLLQEKRLLEKQLSEPDRRLLG-----KRKRRELNMKAQALKLAAKRFIFEYSCGINREN 363
QL+Q + L KQ + +++L G K+ + + +AL+ K + + + N+
Sbjct: 939 QLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997
Query: 364 QQFKKELLQLIEQAQKLTATQSHLENRKQ---QLQQEQWYLES-LIQARQRLQ 412
QQ + +L + +K++ Q++ E ++ QLQ + + ES L+ RQ L+
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Score = 54.7 bits (130), Expect = 2e-07
Identities = 65/307 (21%), Positives = 135/307 (43%), Gaps = 35/307 (11%)
Query: 146 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 205
K ++L K+ T+L +++ A++ D +H Q ++ K+ E+ L ++ E
Sbjct: 679 KQQELNKITTQL-DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT-----------E 726
Query: 206 YLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSS-- 263
L + ++ +V S Q +++++RQ + + K ++KE + S+
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 264 -LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS 322
L++K +A+ I KQE+E Q L+++ + + ET + E+ ++ L+K
Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 323 EPDRRLLG-KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 381
E + + + +L+ + +LK + F +ENQ+ K +L L + ++L
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEF--------EKENQKGKAAILDLEKTCKELK 898
Query: 382 -ATQSHLENR-------KQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQ 433
Q +EN K+ L++E+ E+ Q + L Q + Q+ K Q
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEK---EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955
Query: 434 GTKSRIN 440
+ IN
Sbjct: 956 QLQGNIN 962
Score = 50.1 bits (118), Expect = 4e-06
Identities = 68/288 (23%), Positives = 129/288 (44%), Gaps = 27/288 (9%)
Query: 156 RLKEKIVAEMTDLNK-HIKQAQTQR--KQLLEESRELHREKLLVQAENRFFLEYLTNKTE 212
+L+ ++ A T L++ H++ ++ ++L EE E+ + ++AE + L+ + E
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ-LQQQREEKE 406
Query: 213 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 272
++ Q + N K E ER+ E+ R EQ + L+ KE + L+ KL +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 273 DIAILKEKQEKEIQTLQEETKK-------VQAETASKTREVQAQLLQEKRLLEKQLSEPD 325
+ K E+Q ++TK+ +Q T +K RE Q L Q R Q+ + D
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR----QIGDKD 522
Query: 326 RR------LLGKRKRRELNMKAQALKLAAKRFIFEYSCGI----NRENQQFKKELLQLIE 375
++ LL K K ++ + L AK E + +N ++++ QL E
Sbjct: 523 QKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582
Query: 376 QAQKLTATQSHL-ENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+ + + + EN Q+Q+++ +L + L+ S N+ LN Q
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE-LNSQ 629
Score = 44.3 bits (103), Expect = 2e-04
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 41/291 (14%)
Query: 158 KEKIVAEMTDLNKHIKQAQTQRKQLLEES----RELHREKLLVQAENRFFLEYLTNKTEE 213
+ K++ E+ ++Q +++Q L+E +++ +EK L + E L N+ +
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE-------LVNEKSK 1125
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
E E ++ EI + +E S E I + T L + + K +LQ D
Sbjct: 1126 LAEIEE----IKCRQEKEITKLNEELKSHKLESIKEI-TNLKDAKQLLIQQKLELQGKAD 1180
Query: 274 -IAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQL---LQEKRLLEKQLSEPDRRL- 328
+ E++++ Q L+++ KK + E + E +A+L ++EK + K+ E + +L
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 329 ---------LGKRK-------RRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQ 372
LG K RR ++ Q L + + E + + NQ ++ LL+
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV---QNNQDERRALLE 1297
Query: 373 LIEQAQ-KLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
+ + ++ Q+ + +++L ++ L + Q LQ H Q LNR+
Sbjct: 1298 RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRK 1348
Score = 43.9 bits (102), Expect = 3e-04
Identities = 64/295 (21%), Positives = 128/295 (43%), Gaps = 34/295 (11%)
Query: 149 KLTKVETRLKEKIVAE---MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 205
KL + T+ +++ AE ++ L + +++Q KQL + E L + + + E
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 206 YLTNKTEEYTEQPEKVWNS--YLQKSGEIERRRQESASRYAEQISVLKTAL--LQKENI- 260
L+ E+ ++ N +Q+ + ++ +++ +Q+ AL +QKE
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 261 -QSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAET---ASKTREVQAQLLQEKRL 316
+ L + + +I +K +QEKEI L EE K + E+ + ++ + L+Q+K
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 317 LE------KQLSEPDRR----LLGKRKRRELNMKAQALKLAAKRF--IFEYSCGINRENQ 364
L+ K E ++R L + K+ E +K + ++ AK I E G+ + +
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 365 QFKKELLQLIEQAQKLTATQ----------SHLENRKQQLQQEQWYLESLIQARQ 409
K +Q+ + L + S LE + L+ E LE+ +Q Q
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
Score = 42.7 bits (99), Expect = 7e-04
Identities = 51/206 (24%), Positives = 98/206 (47%), Gaps = 28/206 (13%)
Query: 113 RDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHI 172
+DLQ + + ++E ++ L Y L KP+ L + AE+ L + +
Sbjct: 93 QDLQASLKEEKW-YSEELKKELEKYQGLQQQEAKPDGLVTDSS-------AELQSLEQQL 144
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 232
++AQT+ + ++ ++L +K A + + +Y E+ S + + +
Sbjct: 145 EEAQTENFNI-KQMKDLFEQKAAQLATE------IADIKSKYDEE-----RSLREAAEQK 192
Query: 233 ERRRQESASRYAEQISVLKTALLQKENIQ--SSLKRKL---QAMRDIAILKEKQEKEIQT 287
R E ++ A I LKT LLQ+ I+ + LK++L Q + D L+ +E+E +
Sbjct: 193 VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE--RERESEK 250
Query: 288 LQEETKKVQAETASKTREVQAQLLQE 313
L++E KK+Q++ AS + +QL E
Sbjct: 251 LKDECKKLQSQYASSEATI-SQLRSE 275
Score = 35.0 bits (79), Expect = 0.14
Identities = 58/277 (20%), Positives = 111/277 (40%), Gaps = 33/277 (11%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYL 207
+KL+KV LK ++ K ++ + L + +EL + +L VQ EN
Sbjct: 860 DKLSKVSDSLKNS----KSEFEKENQKGKAAILDLEKTCKEL-KHQLQVQMEN------- 907
Query: 208 TNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRK 267
T + +K L+K E + + + EQ+ + L Q E + L+
Sbjct: 908 -------TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 268 LQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLS----- 322
+ ++ + K+KQ + +Q + + E +K ++ Q QE ++++S
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 323 -----EPDRRLLGKRKRRELNMKA--QALKLAAKRFIFEYSCGINRENQQFKKELLQLIE 375
E ++L RE + A Q LK ++ I+ NQ + +LI+
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN--KLIQ 1078
Query: 376 QAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 412
+ + AT +K+Q QE+ IQ + L+
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 61.6 bits (148), Expect = 1e-09
Identities = 62/275 (22%), Positives = 132/275 (48%), Gaps = 25/275 (9%)
Query: 139 SLINNFVKPEKLTKVETRLK--EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLV 196
S++ +F+K +++ + EK + +L + ++A+ R+Q +EE + E++ +
Sbjct: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKL 572
Query: 197 QAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESAS-RYAEQISVLKTALL 255
+ E R L + E + E+ QK +I+ + +++ R AE+ + K A
Sbjct: 573 KREER--LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAK 630
Query: 256 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 315
+ E +++ K++ +A R + +E++E+ Q L ++ K+ + E K E A+ L E+R
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE--AKRLAEQR 688
Query: 316 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLA------------AKRFIFEYSCGINREN 363
E++ E + +++RRE + Q +LA A+R + E + +
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK 748
Query: 364 QQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 398
+Q ++EL + +K Q L R+ Q +QE+
Sbjct: 749 EQLQREL-----EEKKKKEEQQRLAERQLQEEQEK 778
Score = 60.1 bits (144), Expect = 4e-09
Identities = 67/279 (24%), Positives = 128/279 (45%), Gaps = 33/279 (11%)
Query: 120 LDSRCKFAEGPRRLLPPYHSLIN-NFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQ 178
+D +C F E R+ L ++ +K+ + + R E++ + + + + QA+ +
Sbjct: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARER 587
Query: 179 RKQLLEESRELHREKLLVQAENRFF-LEYLTNKTEEYTEQPEKVWN-SYLQKSGEIE-RR 235
+Q+ EE ++ Q E +F ++ T K +E EK + +K E+E RR
Sbjct: 588 VEQMKEEKKK--------QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 639
Query: 236 RQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKV 295
+QE +R + + +E +Q + + + +R A K E+ Q +E+ ++
Sbjct: 640 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 699
Query: 296 QAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKR--KRRELNMKAQALKLAAKRFIF 353
Q + RE QE+R E+QL+E +RR +R REL + +AL+L ++
Sbjct: 700 QERREQERRE------QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQ--- 750
Query: 354 EYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQ 392
+ RE ++ KK+ E+ Q+L Q E K+
Sbjct: 751 -----LQRELEEKKKK-----EEQQRLAERQLQEEQEKK 779
Score = 54.3 bits (129), Expect = 2e-07
Identities = 79/327 (24%), Positives = 141/327 (43%), Gaps = 39/327 (11%)
Query: 106 LSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEM 165
+SEL + L+DE L + PR P + V+P + T + T + +++
Sbjct: 457 VSELDEEQHLEDEEL-------QPPRSKTPSSPCPASKVVRPLR-TFLHTVQRNQMLMTP 508
Query: 166 TDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSY 225
T + + ++ +R L K + R LE L K E + +KV
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMD-----PKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDK 563
Query: 226 LQKSGEIERRRQESASRYAEQISVLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKE 284
++ E++ +R+E L+ L +E + Q ++K Q + A + EK EK
Sbjct: 564 RRRLEEVKLKREER----------LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Query: 285 IQTLQEETKKVQAETASKTREVQAQLLQE---KRLLEKQLSEPDRR---LLGKRKRRE-- 336
+ E K + A K EV+A+ QE +RL Q E +RR LL K+K E
Sbjct: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE 673
Query: 337 -LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 395
L A+A +LA +R E RE ++ ++E + + Q+ + L ++++ +
Sbjct: 674 RLRKAAEAKRLAEQR---EQE---RREQERREQERREQERREQERREQERQLAEQERRRE 727
Query: 396 QEQWYLESLIQARQRLQGSHNQCLNRQ 422
QE+ E +Q R++ + L R+
Sbjct: 728 QERLQAERELQEREKALRLQKEQLQRE 754
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 59.3 bits (142), Expect = 7e-09
Identities = 67/272 (24%), Positives = 130/272 (47%), Gaps = 32/272 (11%)
Query: 173 KQAQTQRKQLLEESRELHREKLL--VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSG 230
++ Q +R+Q L ++L RE+ L Q E R ++ + E+ ++ ++ +L++
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 231 EIER----RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 286
E ER RR++ R E+ + L++E + +R+ Q +R +E++E+ Q
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-----REQEERREQ 517
Query: 287 TL--QEETKKVQAETASKTR------EVQAQLL---QEKRLLEKQLSEPDRRLLGKRKRR 335
L QEE +++Q S+ + E + QLL +EKRL +++ + +R +R+ +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 336 ELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA----QKLTATQSHLENRK 391
L + + + KR E R Q+ K+E ++ +EQ Q+L + E R+
Sbjct: 578 LLKREEERRQQRLKREQEE------RLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 392 QQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 423
Q L+ E+ Q R+ Q Q L R++
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Score = 58.2 bits (139), Expect = 2e-08
Identities = 70/251 (27%), Positives = 117/251 (46%), Gaps = 28/251 (11%)
Query: 174 QAQTQRKQLLEESRELHREKLLVQAE--NRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 231
+ Q +R++LLE R+ EK + E +R F E + E+ + E V +K E
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQE----EEEKEWRKRETVLRKEEEKLQE 262
Query: 232 IERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEE 291
E +RQ EQ+ L+ L++E + +++ Q +R L+ KQE+E + QEE
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 292 TKKVQ--AETASKTREVQAQLLQEKRLLEKQL---SEPDRRLLGKRKRRELNMKAQALKL 346
++ Q E + RE Q + QE+R E+QL E +RR R+ +E + Q L+
Sbjct: 321 RREQQERREQQEERREQQLRREQEER-REQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 347 AAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQ 406
+ R QQ ++E Q + + Q+L Q R+QQL++EQ
Sbjct: 380 EQQL----------RREQQLRRE--QQLRREQQLRREQQ--LRREQQLRREQQLRREQQL 425
Query: 407 ARQRLQGSHNQ 417
R++ + H Q
Sbjct: 426 RREQEEERHEQ 436
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/274 (25%), Positives = 129/274 (47%), Gaps = 28/274 (10%)
Query: 173 KQAQTQRKQL-----LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
+++Q QR+ LEE R+ R L + + E L + + E+ E+ LQ
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ---EQLRKEQQLLQEEEEE-----LQ 914
Query: 228 KSGEIERRRQESASRYAE--QISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEI 285
+ +RRRQE +Y E Q+ + LL++E + +R+ + R K+ Q+KE
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREK---RRRQERERQYRKDKKLQQKEE 971
Query: 286 QTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK---RKRRELNMKAQ 342
Q L EE +K + + K + +L QE+ L ++ E RR + RK+ EL + +
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031
Query: 343 AL--KLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLE---NRKQQLQQE 397
L + KR + E RE ++ ++E QL+ + ++ T + LE ++++LQQE
Sbjct: 1032 QLLREEREKRRLQERERQY-REEEELQQEEEQLLGE-ERETRRRQELERQYRKEEELQQE 1089
Query: 398 QWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSL 431
+ L ++R Q QC +++ + L
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQL 1123
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/251 (21%), Positives = 114/251 (45%), Gaps = 12/251 (4%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQ----LLEESRELHREKLLVQAENRFFLEYLTN 209
E +L+ + + E+ + KQ Q + +Q EE +E + + +++ E E
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 210 KTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 269
+ E E+ E++ Q+ ER+ +E + + L+ ++ Q +R+ Q
Sbjct: 267 RQRELQEEEEQLRKLERQELRR-ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 270 AMRDIAILKEKQEKEIQTLQEETKKVQA--ETASKTREVQAQLLQEKRLLEKQLSEPDRR 327
R+ +E++E++++ QEE ++ Q E + RE Q + QE+ E+QL +
Sbjct: 326 ERREQQ--EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 328 LLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHL 387
++ RRE ++ + ++ E R QQ ++E EQ ++ +
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 388 ENRKQQLQQEQ 398
E R+Q+L++EQ
Sbjct: 441 ERREQRLKREQ 451
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/282 (21%), Positives = 132/282 (46%), Gaps = 34/282 (12%)
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLE-----YLTNKTEEYTEQPEKVWNSYLQ 227
+Q + QR EE +E R + + + FLE + ++ E+ + + +
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 228 KSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
+ + +RR Q+ + E+ + L K +Q L+++ Q +++ +++E+E +
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKR------------LLEKQLSEPDRRLLG----K 331
QE+ ++ + E + ++ + QLL+E+R +K+L + + +LLG K
Sbjct: 923 RQEQERQYREE--EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 332 RKRRELNMK---AQALKLAAKRFIFEYSCGINRE--NQQFKK--ELLQLIEQAQKLTATQ 384
R+R+E K + L+ ++ + E R+ +Q++K EL Q EQ + +
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 385 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPK 426
L+ R++Q ++E E L Q ++L G + RQ++ +
Sbjct: 1041 RRLQERERQYREE----EELQQEEEQLLGEERETRRRQELER 1078
Score = 53.5 bits (127), Expect = 4e-07
Identities = 47/237 (19%), Positives = 109/237 (45%), Gaps = 17/237 (7%)
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 232
++ Q +R+Q L +E RE+ L + E L+ ++ + E+ L++ E
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 233 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 292
++ R + + LL++E + +++L+ ++ + + + +E++ L++E
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKRE--EERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 293 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 352
++ Q + E + Q L + E++ + RR +R+ + L + + +L +
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR--- 671
Query: 353 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 409
+ RE+++ ++E +L E+ Q + E K ++ + QW LES ARQ
Sbjct: 672 ------LKREHEEERRE-QELAEEEQ-----EQARERIKSRIPKWQWQLESEADARQ 716
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/292 (22%), Positives = 126/292 (43%), Gaps = 9/292 (3%)
Query: 116 QDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQA 175
Q+E + R K E RL S + E+ + + +E+ E + +K+
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 176 QTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERR 235
Q +R+ L + E R++ L + + + L + E EQ E+ ++ E ERR
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 236 RQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILK---EKQEKEIQTLQEET 292
+Q S E+ + Q+E + LKR+ + R LK E++ +E + +EE
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 293 KKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 352
++ + S+ + Q QL E + ++ R+ G+R+R+E K + + +
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 353 FEYSCGINRENQQFKKELLQLIEQ------AQKLTATQSHLENRKQQLQQEQ 398
E + +E +Q + Q + Q+L+A E R++QL+ E+
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/302 (19%), Positives = 138/302 (45%), Gaps = 33/302 (10%)
Query: 138 HSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQ 197
H+L E+L K + L+E+ + +++ + ++++ E+ R+ E+ L Q
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEE--------EEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 198 AENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI------ERRRQESASRYAEQISVLK 251
E + E + + E+ + QK ++ +RRRQE +Y E+
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE--- 995
Query: 252 TALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLL 311
LQ+E Q + + + R + +++ E+Q QEE + ++ E + + + +
Sbjct: 996 ---LQQEEEQLLREEREKRRRQEWERQYRKKDELQ--QEEEQLLREEREKRRLQERERQY 1050
Query: 312 QEKRLLEKQLSEPDRRLLGK----RKRRELN---MKAQALKLAAKRFIFEYSCGINRENQ 364
+E E++L + + +LLG+ R+R+EL K + L+ ++ + E R+ +
Sbjct: 1051 RE----EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 365 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDV 424
+ + + ++Q ++ + + R+Q+L+++ E + Q ++L + RQ++
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Query: 425 PK 426
+
Sbjct: 1167 ER 1168
Score = 50.8 bits (120), Expect = 2e-06
Identities = 66/282 (23%), Positives = 119/282 (42%), Gaps = 40/282 (14%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF---- 203
EK + E + + E+ + + + + ++++L E R+ E+ L Q E +
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 204 -------LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQ 256
LE K EE ++ E++ +K ER RQ R E++ + LL+
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQ---CREEEELQQEEEQLLR 1125
Query: 257 KENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL 316
+E + +R+ + R +E Q++E Q L+EE +K + + + + +L QE+
Sbjct: 1126 EEREK---RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 317 L------------EKQLSEPDRRLLGKRKRR--------ELNMKAQALKLAAKRFIFEYS 356
L E+Q E + KRK+R +L + + K A R Y
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 357 CGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQ 398
G REN+QF++ + Q Q HL +Q+ +EQ
Sbjct: 1243 KG--RENEQFRQLEDSQLRDRQSQQDLQ-HLLGEQQERDREQ 1281
Score = 48.9 bits (115), Expect = 9e-06
Identities = 49/278 (17%), Positives = 125/278 (44%), Gaps = 15/278 (5%)
Query: 145 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFL 204
++ E+ + E +L+ + E + +Q + +R+Q L ++L RE+ L + E +
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL-RREQQLRR 397
Query: 205 EYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSL 264
E + ++ + + L++ ++ R ++E ++E + L
Sbjct: 398 EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH----------EQERREQRL 447
Query: 265 KRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEP 324
KR+ + RD LK ++E E + ++++ + + RE +L +E+R +++ E
Sbjct: 448 KREQEERRD--WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 325 DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 384
R + +R + + + + +R E + RE ++ +++LL+ E+ + +
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LRREQEERREQLLKREEEKRLEQERR 563
Query: 385 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQ 422
R+Q+ +++Q + +QRL+ + L ++
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Score = 48.9 bits (115), Expect = 9e-06
Identities = 61/267 (22%), Positives = 119/267 (44%), Gaps = 27/267 (10%)
Query: 164 EMTDLNKHIKQAQTQRKQLLEESRELHRE--KLLVQAENRFFLEYLTNKTEEYTEQPEKV 221
++ D +Q+Q + LL E +E RE + Q +R F E + EE E +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 222 WNSY-----LQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 276
S L++ E +RRRQE+ ++ E+ +L+ +R+ Q +R
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ-------------EREEQPLRRQER 1358
Query: 277 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRE 336
++ +E+E++ ++ K ++ E + +E + + L+E++ L Q E +++L R R+
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ--EREQQLRQDRDRKF 1416
Query: 337 LNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQ 396
+ Q + R E + R+ ++ K +E+ Q+L + ++QL Q
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERK-----FLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 397 EQWYLESLIQARQRLQGSHNQCLNRQD 423
E+ + Q R R Q L RQ+
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQE 1498
Score = 48.1 bits (113), Expect = 2e-05
Identities = 54/254 (21%), Positives = 114/254 (44%), Gaps = 42/254 (16%)
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 232
++ Q Q ++L E + +++ L Q + + E L + +E+ E+ E+ + ++
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER-----RAEEEQL 193
Query: 233 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ----TL 288
+ + + ++ + + LL+ K++ + R + +E++EKE + L
Sbjct: 194 QSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 289 QEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 348
++E +K+Q E + RE+Q + E+QL + +R+ L +R+R+E + Q L+
Sbjct: 254 RKEEEKLQEEEPQRQRELQEE--------EEQLRKLERQEL-RRERQEEEQQQQRLR--- 301
Query: 349 KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQAR 408
RE Q +K+ + EQ + E R+QQ ++EQ Q R
Sbjct: 302 ------------REQQLRRKQEEERREQQE---------ERREQQERREQQEERREQQLR 340
Query: 409 QRLQGSHNQCLNRQ 422
+ + Q L R+
Sbjct: 341 REQEERREQQLRRE 354
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/249 (22%), Positives = 106/249 (42%), Gaps = 45/249 (18%)
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 232
KQ +R+Q EE R +L Q E R + +E ++ + W ++ E
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAH-----RQQQEEEQRRDFTWQWQAEEKSER 779
Query: 233 ERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEET 292
R+R + EQ +R+L+A +E+Q++E + L EE
Sbjct: 780 GRQRLSARPPLREQ-----------------RERQLRA-------EERQQREQRFLPEEE 815
Query: 293 KKVQAETASKTREVQAQLLQEKRLLEKQ------------LSEPDRRLLGKRKRRELNMK 340
+K Q + RE + Q L+E+ L+++ L E R + +RR+ +
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 341 AQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWY 400
Q + +R Y+ +E + +++LLQ E+ ++L + E R++Q Q+ Q+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ--EEEEEL--QREEREKRRRQEQERQYR 931
Query: 401 LESLIQARQ 409
E +Q +
Sbjct: 932 EEEQLQQEE 940
Score = 48.1 bits (113), Expect = 2e-05
Identities = 65/299 (21%), Positives = 124/299 (41%), Gaps = 30/299 (10%)
Query: 146 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 205
+P + + + + +E+ + K +++ Q R+Q E ++L Q + +
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Query: 206 YLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQK--ENIQSS 263
K E +Q + + E + RRQE ++ E+ L+ +K E Q
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 264 LKRKLQAM----RDIAILKEKQ------------EKEIQTLQEETKKVQAETASKTREVQ 307
+R+ Q + RD L+E+Q E+E+++ + E K ++ E ++ Q
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 308 AQLLQEKRLLEKQLSEPDRRLLGKRKRRE---LNMKAQALKLAAKRFIFEYSCGINRENQ 364
+ LQE++ L +Q RR RK RE L + + +L+ + E E Q
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ----ERDRKFRLEEQ 1586
Query: 365 QFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 423
+ +++ EQ +K + L ++ Q Q Q + Q LQ Q L+RQ+
Sbjct: 1587 KVRRQ-----EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Score = 48.1 bits (113), Expect = 2e-05
Identities = 67/308 (21%), Positives = 133/308 (43%), Gaps = 35/308 (11%)
Query: 125 KFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLE 184
KF E ++L H F + E+L ++ R ++++ + D K +++ Q R+Q E
Sbjct: 1447 KFLEEEQQLRQERH---RKFREEEQL--LQEREEQQLHRQERD-RKFLEEEQQLRRQ--E 1498
Query: 185 ESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYA 244
R+ ++L Q R FLE EE ++ +LQ+ ++ R+ + R
Sbjct: 1499 RDRKFREQELRSQEPERKFLE------EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 245 EQISVLKTALLQKENIQSSLKRKLQ----AMRDIAILKEKQEKEIQT------LQEETKK 294
+ L++E + L R+ + + + + +++QE++ QE ++
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 295 VQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFE 354
++ E K RE + QLLQE+ + E DR+ L + + + Q L+ R E
Sbjct: 1613 LRQERDRKFREDE-QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 355 YSCGINRENQQ----------FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 404
+ +Q F++E QL Q ++ Q + R+Q+L+++ E L
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 405 IQARQRLQ 412
Q ++ Q
Sbjct: 1732 RQETEQEQ 1739
Score = 47.8 bits (112), Expect = 2e-05
Identities = 63/260 (24%), Positives = 115/260 (44%), Gaps = 35/260 (13%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E +L+ K E + + ++ Q +R E+ E ++L + E R + + EE
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERR----EQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 214 YTEQPEKVWNSYLQKSGEIERR----RQESASRYAEQISVLKTALLQKENIQSSLKRKLQ 269
EQ L++ E ERR R+E R +Q+ + L++E L+R+ Q
Sbjct: 359 RREQ-------QLRREQEEERREQQLRREQQLRREQQLR--REQQLRRE---QQLRREQQ 406
Query: 270 AMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQE--------KRLLEKQL 321
R+ + +E+Q + Q L+ E ++ + E + + +L +E KR E +
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 322 SEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLT 381
E +RR ++ +E + + LKL + E R QQ ++E + EQ K
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEE----ERREQQERREQQLRREQEERREQRLKRQ 522
Query: 382 ATQSHLENR---KQQLQQEQ 398
+ L+ R +QQL++EQ
Sbjct: 523 EEEERLQQRLRSEQQLRREQ 542
Score = 45.8 bits (107), Expect = 8e-05
Identities = 52/254 (20%), Positives = 115/254 (45%), Gaps = 22/254 (8%)
Query: 173 KQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEI 232
+Q + + +QL E E RE+ L + + E + ++ + + L++ ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401
Query: 233 ERRRQ---ESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQ 289
R +Q E R +Q+ + L++E + ++K + R LK +QE+ L+
Sbjct: 402 RREQQLRREQQLRREQQLR--REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 290 EETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAK 349
E + + E + ++++ +E+R +L E +RR +++RRE ++ + + +
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE--QQERREQQLRREQEERREQ 517
Query: 350 RFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQ 409
R + Q+ ++ L Q + Q+L Q E R+Q L++E+ E ++ +
Sbjct: 518 RL----------KRQEEEERLQQRLRSEQQLRREQE--ERREQLLKREE---EKRLEQER 562
Query: 410 RLQGSHNQCLNRQD 423
R Q + R+D
Sbjct: 563 REQRLKREQEERRD 576
Score = 40.8 bits (94), Expect = 0.002
Identities = 66/310 (21%), Positives = 133/310 (42%), Gaps = 49/310 (15%)
Query: 125 KFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQ-TQRKQLL 183
KF E + L ++ + K + E +L+ + E +H + + + +QLL
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ---EREQQLRHDRDRKFREEEQLL 1676
Query: 184 EESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRY 243
+E E ++L Q +R F E EE + ++ +LQ+ ++ R+ E R
Sbjct: 1677 QEGEE---QQLRRQERDRKFRE------EEQQLRRQERERKFLQEEQQLRRQELERKFRE 1727
Query: 244 AEQI----------------SVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQT 287
EQ+ +L+ L+ E + L+R+ RD K ++E++++
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ---ERD---RKFREEEQLRQ 1781
Query: 288 LQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLA 347
+EE + E+ K RE + QL QE+ E+QL R + + +L ++ Q +L
Sbjct: 1782 EREEQQLRSQESDRKFRE-EEQLRQERE--EQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838
Query: 348 AKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQA 407
+ R+ Q +E E++++ E +K++ ++E+ E I+
Sbjct: 1839 QE-----------RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887
Query: 408 RQRLQGSHNQ 417
+Q+ + H Q
Sbjct: 1888 QQKEEQRHRQ 1897
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 59.3 bits (142), Expect = 7e-09
Identities = 60/257 (23%), Positives = 116/257 (45%), Gaps = 28/257 (10%)
Query: 157 LKEKIVAEMTDLNKHIKQAQTQRKQLLEESREL-HREKLLVQAENRFFLEYLTNKTEEYT 215
L+ + AE + +T + QL E+++EL H + L A+ L K ++++
Sbjct: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE--LAAFRTKVQDHS 1203
Query: 216 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 275
+ ++ W + + + + R+ S E++S+L +L+KE LKR + A +
Sbjct: 1204 KAEDE-WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE-- 1260
Query: 276 ILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRR 335
+K E+ ++ LQ ET A A ++ ++ ++ + EKQ R+ + R+
Sbjct: 1261 -KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ------RVASENLRQ 1313
Query: 336 ELNMKA-------QALKLAAKRFIFEYSCGI------NRENQQFKKELLQLIEQAQKLTA 382
EL +A Q LK ++F F+ + + Q ELL Q+L A
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKF-FQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
Query: 383 TQSHLENR-KQQLQQEQ 398
Q+ E R +++L+Q +
Sbjct: 1373 EQAAAEKRHREELEQSK 1389
Score = 50.8 bits (120), Expect = 2e-06
Identities = 56/253 (22%), Positives = 109/253 (43%), Gaps = 28/253 (11%)
Query: 158 KEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQ 217
K+++ + +TDL I +Q K+ LE++ + H +L Q + + T E T
Sbjct: 461 KQQLSSLITDLQSSISNL-SQAKEELEQASQAHGARLTAQ---------VASLTSELTTL 510
Query: 218 PEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAIL 277
+ Q+ E+ +Q++ + A+ L L Q+E L+ +++ +
Sbjct: 511 NATIQ----QQDQELAGLKQQAKEKQAQ----LAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 278 KEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRREL 337
KE+Q KE+ QE T++ A+ + E + L+E+ KQL L K K +L
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL-----EALEKEKAAKL 617
Query: 338 NMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQE 397
+ Q L++A E Q ++E +L + ++L A + + Q +
Sbjct: 618 EILQQQLQVAN-----EARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 398 QWYLESLIQARQR 410
LE +++ Q+
Sbjct: 673 VAELELQLRSEQQ 685
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/289 (24%), Positives = 129/289 (44%), Gaps = 28/289 (9%)
Query: 145 VKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF- 203
++P++L ++ + E + + + K + +T++ Q+ + +L E + + R F
Sbjct: 273 LEPKELEELRDK-NESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 204 --LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQ 261
L+ L + E TE+ K +L+K ++E ++ SA+ ++ K +LQ +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGK--L 387
Query: 262 SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAET-ASKTREVQAQLLQEKRLLEKQ 320
S L+ L ++D +EK E LQ ET K +A T A+ ++QA++ +LE +
Sbjct: 388 SQLEEHLSQLQDNP-PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV----EMLETE 442
Query: 321 LSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQ-- 378
+ + +LL +R E K I + I+ +Q KE L+ QA
Sbjct: 443 RGQQEAKLLAERGHFEEE------KQQLSSLITDLQSSISNLSQ--AKEELEQASQAHGA 494
Query: 379 KLTA----TQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 423
+LTA S L +QQ+ L L Q + Q Q L +Q+
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Score = 45.8 bits (107), Expect = 8e-05
Identities = 57/212 (26%), Positives = 93/212 (43%), Gaps = 34/212 (16%)
Query: 154 ETRLKE-KIVAEMTDLNKHIKQAQTQ--RKQLLEESRELH--REKLLVQAEN-RFFLEYL 207
ETRL E + A+ T + A+ + + ++LEE + R+KL Q E F
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 208 TNKTEEYT------EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQ 261
T + EE + +Q KV L+ Q+ A R Q++ L+ L QKE
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Query: 262 SSLKRKLQAMRDIAILKEKQEKEIQ-------TLQEETKKVQAETASKTREVQAQLLQEK 314
K +++ + K++Q +E+Q LQ+E K+++AE E+Q L+ K
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTK 1667
Query: 315 -------------RLLEKQLSEPDRRL--LGK 331
R LE Q++ D++L LGK
Sbjct: 1668 EAEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 39.7 bits (91), Expect = 0.006
Identities = 75/353 (21%), Positives = 144/353 (40%), Gaps = 37/353 (10%)
Query: 76 KLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLP 135
K E +A +LQ Q+ A SL VT L + + L+ + + L
Sbjct: 686 KATEKERVAQEKDQLQEQL-QALKESLKVTKGSLEEEKRRAADALEEQQRCIS---ELKA 741
Query: 136 PYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNK-HIKQAQTQRKQLLEESRELHREKL 194
SL+ + K + E ++ + A + L + H + + R++L E H
Sbjct: 742 ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT--- 798
Query: 195 LVQAENRFFLEYLTNKTEEY--TEQPEKVWNSYLQKS-----GEIERRRQE---SASRYA 244
++E ++ + E Y ++Q E + + Q+ E E+ RQE + + A
Sbjct: 799 -AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 245 --EQISVLKTALLQKE--NIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETA 300
E S L+ + Q E + ++L R LQ +++ + +K ++ TLQE+ E A
Sbjct: 858 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 301 SKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
V+ Q++ + + EP R G R+ L + ++F C
Sbjct: 918 RLETLVRKAGEQQETASRELVKEPAR--AGDRQPEWLE------EQQGRQF-----CSTQ 964
Query: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ-QEQWYLESLIQARQRLQ 412
Q ++E Q+ + ++L A + ++Q+ + Q++ + L Q R R Q
Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
Score = 39.7 bits (91), Expect = 0.006
Identities = 54/279 (19%), Positives = 115/279 (41%), Gaps = 22/279 (7%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQL---LEESRELHREKLLVQAENRFFLEYLT 208
K ETR +V + K +++ + RK L L++ E H+ + V
Sbjct: 740 KAETR---SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 209 NKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKL 268
+ E EQ K ++ ++ + ++ + + + EQ+ LK E + + +
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK------EECEKARQELQ 850
Query: 269 QAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRL 328
+A +A ++ E +I Q E ++ A A ++VQ + ++ ++L + LS ++
Sbjct: 851 EAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD-DLSTLQEKM 909
Query: 329 LGKRKR----RELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 384
K L KA + A R + + ++ +E +Q ++ +TQ
Sbjct: 910 AATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEE-----QQGRQFCSTQ 964
Query: 385 SHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQD 423
+ L+ +++ +Q LE L A QG + +Q+
Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE 1003
Score = 38.1 bits (87), Expect = 0.016
Identities = 65/361 (18%), Positives = 142/361 (39%), Gaps = 46/361 (12%)
Query: 110 HSCRDLQDEC----------LDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKE 159
H C+ LQ E L+ + A G R L + + + + R +
Sbjct: 1365 HLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ 1424
Query: 160 KIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEY-LTNKTEEYTEQP 218
++ AE + + + L EE+R L L R FLE L E+Y ++
Sbjct: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL----GRQFLEVELDQAREKYVQEL 1480
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA----LLQKENIQSSLKRKLQAMRDI 274
V + E++R Q +A + + A L +++ Q ++ + +
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540
Query: 275 AILKEKQEKEIQTL--------------QEETKKVQAETA----------SKTREVQAQL 310
+ + +Q K+++ L Q++ K VQA+ ++ E+QAQL
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 311 LQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKEL 370
Q+++ E + ++ +++ N + Q +L + + + + + E ++ EL
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQE-QLRSLEQLQKENKELRAEAERLGHEL 1659
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPS 430
Q + ++ T HL + + L+ + + + ++ + Q + + +R+ P+ P
Sbjct: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE--PQAKPQ 1717
Query: 431 L 431
L
Sbjct: 1718 L 1718
Score = 37.4 bits (85), Expect = 0.027
Identities = 53/288 (18%), Positives = 126/288 (43%), Gaps = 48/288 (16%)
Query: 161 IVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEK 220
+ +E+T LN I+Q + L ++++E QA+ L+ ++ Q E+
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEK-------QAQLAQTLQQQEQASQGLRHQVEQ 555
Query: 221 VWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEK 280
+ +S QK +++ ++ + + L TA ++E +SL+ + A++ + L+++
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE---ASLRERDAALKQLEALEKE 612
Query: 281 QEKEIQTLQEETK--------------KVQAETASKTREV-----------------QAQ 309
+ +++ LQ++ + + Q E A +R+V QAQ
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 310 LLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKE 369
+ + + L + + + +++ +L + QALK + K + G E ++ +
Sbjct: 673 VAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK-----VTKGSLEEEKRRAAD 727
Query: 370 LLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 417
L+ EQ + ++ ++ + +Q ++E+ LE R+ L+ Q
Sbjct: 728 ALE--EQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Score = 33.9 bits (76), Expect = 0.30
Identities = 56/293 (19%), Positives = 125/293 (42%), Gaps = 36/293 (12%)
Query: 148 EKLTKVETRLKEKIVA---EMTDLNKHIKQAQTQ------RKQLLEESRELHREKLLVQA 198
EK+ +E+ + +I E+ +L+ ++ +A Q R Q L + +EK+ +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATS 913
Query: 199 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERR--RQESASRYAEQISVLKTALLQ 256
+ LE L K E E + ++G+ + ++ ++ + L+ +
Sbjct: 914 KEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMERE 973
Query: 257 KENIQSSLKRKLQAMRDIAILKEK----QEKEIQTLQEETKKVQAETA---SKTREVQAQ 309
E + + L+R A+ + +++ QE+E+ L +E + QA+ A + E++ +
Sbjct: 974 AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMR 1033
Query: 310 L---LQEKRLLEKQLSEPDRRLLGKRKRRELNM-KAQALKLAAKRFIFEYSCGINRENQQ 365
L L E+R+ L E L +++ ++ + K + L+ A + + E + + +Q
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 366 FKKELLQLIE--------------QAQKLTATQSHLENRKQQLQQEQWYLESL 404
K+ + KL A ++ + +QQ Q++Q +SL
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Score = 31.2 bits (69), Expect = 2.0
Identities = 59/269 (21%), Positives = 104/269 (38%), Gaps = 40/269 (14%)
Query: 150 LTKVETRLKEKIVAEMTDLNKHIKQAQT---QRKQLLEESRELHREKLLVQAENRFFLEY 206
L + E +LKE + H +Q T +R+ L E ++ ++ E LE
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619
Query: 207 LTNKTEEYTEQPEKVWNSYLQKSGE--------------IERRRQESASRYAEQISVLKT 252
L + + E + S Q E +E RQE A Q++ L+
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA-QVAELEL 678
Query: 253 ALLQKENIQSSLKR----KLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 308
L ++ + +R K Q + LKE + +L+EE K+ A+ + + +
Sbjct: 679 QLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEE-KRRAADALEEQQRCIS 737
Query: 309 QLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKK 368
+L E R L +Q KR+R+EL + K R + + E + ++
Sbjct: 738 ELKAETRSLVEQ---------HKRERKELEEERAGRKGLEAR-LQQLGEAHQAETEVLRR 787
Query: 369 ELLQLIEQAQKLTATQSHLENRKQQLQQE 397
EL + + A Q E+ +QL +E
Sbjct: 788 ELAEAM-------AAQHTAESECEQLVKE 809
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 58.5 bits (140), Expect = 1e-08
Identities = 55/254 (21%), Positives = 117/254 (46%), Gaps = 16/254 (6%)
Query: 158 KEKIVAEMTDLNKHIKQAQTQ-RKQLLEESRELHREKLLV----QAENRFFLEYLTNKTE 212
++K + +L + ++ + + R+Q++E+ + E+ L+ + E LEY+ E
Sbjct: 236 RQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQMLEYMEQLQE 295
Query: 213 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTA-LLQKENIQSSLKRKLQAM 271
E + E+ L+ EI+R E+ + AE ++ K A + E + + R+ +
Sbjct: 296 EDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFE 355
Query: 272 RDIAILKEKQEKEI---QTLQEETKKVQAET----ASKTREVQAQLLQEKRLLEKQLSEP 324
+ ++ ++EKEI + +QE+ + QAE A + +EV + + K +
Sbjct: 356 AEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKME 415
Query: 325 DRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQ 384
L K + ++ K AL + +R E+ + + +Q +KE L E+ +K T
Sbjct: 416 TEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL---EEEKKATGRL 472
Query: 385 SHLENRKQQLQQEQ 398
H ++Q+++ Q
Sbjct: 473 QHANELRRQVRENQ 486
Score = 31.6 bits (70), Expect = 1.5
Identities = 33/164 (20%), Positives = 68/164 (41%), Gaps = 13/164 (7%)
Query: 157 LKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTE 216
L+ K E+ D K+ + RK++ E EL + +L A L + + E
Sbjct: 389 LRAKRNQEVADREWRRKEKENARKKM-ETEAELRKSRLEQVAFKEHALAVQVQRDRDEFE 447
Query: 217 QPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAI 276
+ + ++K E ++ ++A ++ +EN Q ++ ++ +
Sbjct: 448 RILRAQREQIEKERLEEEKKATGRLQHANELR-----RQVRENQQKEVQNRIATFEEGRR 502
Query: 277 LKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQ 320
LKE+ +K + + E +K K E++A L EK +E +
Sbjct: 503 LKEEAQKRRERIDEIKRK-------KLEELRATGLPEKYCIEAE 539
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 58.2 bits (139), Expect = 2e-08
Identities = 64/272 (23%), Positives = 136/272 (50%), Gaps = 28/272 (10%)
Query: 137 YHSLINNFVKPE-KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLL 195
+ S+ + +KPE +L + +L+ + V E L + +Q QTQ+ Q E + L +++ L
Sbjct: 138 HQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQ---EQQVLQQQEQL 194
Query: 196 VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALL 255
Q + L + +E +Q + LQ+ ++++++ + +Q L L
Sbjct: 195 QQQVQE---QQLLQQQQEQLQQQQ-----LLQQQEQLQQQQFQQQQEQLQQQQQL-LLLQ 245
Query: 256 QKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 315
Q+ +Q L ++ QA +L+++Q + LQ++ Q E + ++ Q Q+++
Sbjct: 246 QQGQLQQQLLQQQQAQLQQQLLEQQQAQ----LQQQLLLQQQEQLQQQQQQQLLQQQQEQ 301
Query: 316 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR----ENQQFKKEL- 370
L ++QL P L + E+ ++ + L +++ + + + R E QQ +++L
Sbjct: 302 LQQQQLQPPP---LEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQ 358
Query: 371 LQLIEQAQKLTATQSHLENRKQQLQQEQWYLE 402
L+L E+ Q+L + LE ++QQL+Q++ LE
Sbjct: 359 LKLQEELQQL---EQQLEQQQQQLEQQEVQLE 387
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/250 (24%), Positives = 116/250 (46%), Gaps = 37/250 (14%)
Query: 181 QLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESA 240
++ EE+R RE L Q E + E +QP+ Q E++++ Q+
Sbjct: 77 EIAEETRPGQRELQLQQLEQQ----------PEPQQQPQHEQLQQPQPHLELQQQPQQDG 126
Query: 241 SRYAEQISVLKTALLQKENIQS----SLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQ 296
+ Q LQ+E QS LK +LQ M L+ +Q +E Q LQ++ +++Q
Sbjct: 127 QQQLSQ--------LQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQ 178
Query: 297 AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS 356
+ A + Q+LQ++ L++Q+ E + + ++ + Q +L ++F +
Sbjct: 179 TQQAQ-----EQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-- 231
Query: 357 CGINRENQQFKKELLQLIEQA----QKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 412
+E Q +++LL L +Q Q L Q+ L+ + + QQ Q + L+Q +++LQ
Sbjct: 232 ----QEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQ 287
Query: 413 GSHNQCLNRQ 422
Q L +Q
Sbjct: 288 QQQQQQLLQQ 297
Score = 47.4 bits (111), Expect = 3e-05
Identities = 61/267 (22%), Positives = 125/267 (46%), Gaps = 34/267 (12%)
Query: 173 KQAQTQRKQLLEESRELHREKLL----VQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQK 228
K ++L E + +H+++ L VQ + R + +T++ EQ LQ+
Sbjct: 137 KHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQ 196
Query: 229 SGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTL 288
+ ++ Q+ + +Q + + LQ++ Q + +LQ + + +L+++ + + Q L
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ-QEQLQQQQQLLLLQQQGQLQQQLL 255
Query: 289 QEETKKVQAETASKTREVQAQLLQEKRLLEKQ---LSEPDRRLLGKRKRRELNMKAQALK 345
Q++ QA+ + E Q LQ++ LL++Q + ++LL +++ + + Q
Sbjct: 256 QQQ----QAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPP 311
Query: 346 LAAKRFIFEYSCGINRENQQFKKELLQL-IEQAQKLTATQSHLENRKQQL--QQEQWYL- 401
L + E ++ + EL+ + + Q+L + LE R+Q+L QQEQ L
Sbjct: 312 LEPE------------EEEEVELELMPVDLGSEQELEQQRQELE-RQQELERQQEQRQLQ 358
Query: 402 ----ESLIQARQRLQGSHNQCLNRQDV 424
E L Q Q+L+ Q L +Q+V
Sbjct: 359 LKLQEELQQLEQQLEQQQQQ-LEQQEV 384
Score = 37.0 bits (84), Expect = 0.036
Identities = 39/177 (22%), Positives = 88/177 (49%), Gaps = 17/177 (9%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREK---LLVQAENRFFLEYLT 208
+++ +L ++ A++ +QAQ Q++ LL++ +L +++ LL Q + + + L
Sbjct: 249 QLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQ 308
Query: 209 NKTEEYTEQPE---KVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK 265
E E+ E ++ L E+E++RQE R E L+++ Q L+
Sbjct: 309 PPPLEPEEEEEVELELMPVDLGSEQELEQQRQE-LERQQE---------LERQQEQRQLQ 358
Query: 266 RKLQA-MRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQL 321
KLQ ++ + E+Q+++++ + + + E ++ +EVQ +L + L+ +L
Sbjct: 359 LKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLEL 415
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 57.8 bits (138), Expect = 2e-08
Identities = 77/369 (20%), Positives = 152/369 (41%), Gaps = 39/369 (10%)
Query: 74 TNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRL 133
T +L EL E +T+ +A AH+L S H C L+++ + + AE R L
Sbjct: 1313 TQQLEELKR----QMEEETKAKNAMAHALQ---SSRHDCDLLREQYEEEQEAKAELQRAL 1365
Query: 134 LPPYHSLINNFVKPE----KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESREL 189
+ K E + T+ K+K+ + + ++ + A ++ L + + L
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRL 1425
Query: 190 HRE--KLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKS-GEIERRRQESAS----- 241
E L+ E +K + ++ W L +S E+E ++ES S
Sbjct: 1426 QGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL 1485
Query: 242 -----RYAEQISVLKTALLQKENIQSSLK----------RKLQAMRDIAILKEKQEKEIQ 286
Y E + L+T + +N+Q + + LQ L E+++ ++Q
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQ 1545
Query: 287 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKL 346
EE + SK VQ +L Q K L++++ E D + ++ +R A+AL+
Sbjct: 1546 VALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEI--EQLKRNSQRAAEALQS 1603
Query: 347 AAKRFIFEYSCGINRENQQ---FKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLES 403
I + + + + + +QL +++ TQ HL + QL+ Q +L+
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663
Query: 404 LIQARQRLQ 412
+++ + L+
Sbjct: 1664 ALRSNEDLK 1672
Score = 45.4 bits (106), Expect = 1e-04
Identities = 66/352 (18%), Positives = 142/352 (40%), Gaps = 51/352 (14%)
Query: 89 ELQTQVPDASAHSLAVT--LSELHSCRDLQDECLDS----RCKFAEGPRRLLPPYHSLIN 142
+LQ ++ D HSL + EL + + +E +++ R K + L +
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE 1152
Query: 143 NFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRF 202
+ T + + +K AE + + +++A Q + R+
Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK-------------- 1198
Query: 203 FLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQS 262
+ + E E++ N K ++E+ + E + S ++ K NI+
Sbjct: 1199 ------KQADSVAELGEQIDNLQRVKQ-KLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251
Query: 263 SLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQ------AQLLQEKRL 316
+ + +I E+Q + I L + ++Q + + V+ +QL + K+
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQA 1311
Query: 317 LEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR----ENQQFKKELLQ 372
L +QL E R++ + K + N A AL+ + + C + R E Q+ K EL +
Sbjct: 1312 LTQQLEELKRQMEEETKAK--NAMAHALQSS------RHDCDLLREQYEEEQEAKAELQR 1363
Query: 373 LI-----EQAQKLTATQSHLENRKQQLQQEQWYL-ESLIQARQRLQGSHNQC 418
+ E AQ T ++ R ++L++ + L + L +A + + ++++C
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Score = 42.7 bits (99), Expect = 7e-04
Identities = 46/180 (25%), Positives = 89/180 (49%), Gaps = 18/180 (10%)
Query: 249 VLKTALLQKE--NIQSSLKR-KLQAMRDIAILKEKQEKEIQTLQEETK---KVQAETAS- 301
+LK+A +KE ++ +R K + R A KE +EK + LQE+ +VQ+ET +
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 302 -KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGIN 360
E L++ K LLE ++ E RL + E+N + +A KR + + +
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERL---EEEEEMNSEL----VAKKRNLEDKCSSLK 955
Query: 361 RENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLN 420
R+ + L L + ++ AT++ ++N +++ + + L + ++ LQ +H Q L+
Sbjct: 956 RDIDDLE---LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLD 1012
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/354 (19%), Positives = 144/354 (40%), Gaps = 43/354 (12%)
Query: 89 ELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPE 148
E Q ++ A S +++ +EL R+ +E +D + L L +
Sbjct: 1466 ESQAELEAAQKESRSLS-TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524
Query: 149 KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF----- 203
K + + K+ + E +DL +++ + + EES+ L + L Q ++
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH--EESKILRVQLELSQVKSELDRKVIE 1582
Query: 204 ----LEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQE--------------SASRYAE 245
+E L ++ E + V ++ ++ + R +++ S + AE
Sbjct: 1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 246 QISVLKTALLQKENIQSSLKRKLQAMRDI----AILKEKQEKEIQTLQEETKKVQAETAS 301
L+T Q ++ Q L L++ D+ AI++ + ++ L+E KV E
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE--MKVALEQTE 1700
Query: 302 KTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINR 361
+TR + Q L + + L + L+ +K+ E + +A + E S +R
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD-------IAQCQAEVENSIQESR 1753
Query: 362 ENQQFKKELL----QLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRL 411
++ K+ + + E+ +K T +HLE K+ L+Q L+ + ++L
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Score = 38.5 bits (88), Expect = 0.012
Identities = 59/269 (21%), Positives = 117/269 (43%), Gaps = 31/269 (11%)
Query: 141 INNFVKPEKLTKVETRLKEKIVA--EMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQA 198
+N F K + L K KE + + + +++ +RK+L E+ L +EK +Q
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 199 ENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKE 258
+ + ++TE + E+ ++ +E + +E R E+ + + +K
Sbjct: 894 Q-------VQSETENLMDAEERC-EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 259 NIQ---SSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKR 315
N++ SSLKR + D+ + K EKE + + K + E + + ++L +EK
Sbjct: 946 NLEDKCSSLKRDID---DLELTLTKVEKEKHATENKVKNLSEEMTALEENI-SKLTKEK- 1000
Query: 316 LLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIE 375
K L E ++ L + E + +K+ AK + + + + +Q KK L
Sbjct: 1001 ---KSLQEAHQQTLDDLQVEEDKVNG-LIKINAK--LEQQTDDLEGSLEQEKKLRADLER 1054
Query: 376 QAQKLTA-------TQSHLENRKQQLQQE 397
+KL + LEN KQQ++++
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Score = 33.9 bits (76), Expect = 0.30
Identities = 59/315 (18%), Positives = 133/315 (42%), Gaps = 67/315 (21%)
Query: 148 EKLTKVETR---LKEKIVAEMTDLNKHIKQAQTQRKQLL---EESRELHREKLLVQAENR 201
E+L + E R L+EK+V+ + + N Q Q++ + L+ E L + K+L++A+ +
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVK 924
Query: 202 FFLEYLTNKTEEYTEQPEKVWN------SYLQKSGEIE------RRRQESASRYAEQISV 249
E L + E +E K N S + ++E + + + + +S
Sbjct: 925 ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984
Query: 250 LKTALLQKENIQSSLKRKL-------QAMRDIAILKEK-------------QEKEIQTLQ 289
TAL +ENI K K Q + D+ + ++K Q +++
Sbjct: 985 EMTAL--EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 290 EETKKVQAETASKTREVQAQLLQ----------EKRLLEKQLSEPDRRLLGKRKRRELNM 339
E+ KK++A+ R+++ L +K+ +E++L K++E +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKL-----------KKKEFEL 1091
Query: 340 KAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQW 399
K+ ++ +S ++ ++ + + +L E+ + ++ +E ++ L +E
Sbjct: 1092 SQLQAKIDDEQV---HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE-- 1146
Query: 400 YLESLIQARQRLQGS 414
LE + + + G+
Sbjct: 1147 -LEEISERLEEASGA 1160
Score = 28.9 bits (63), Expect = 9.8
Identities = 44/198 (22%), Positives = 81/198 (40%), Gaps = 20/198 (10%)
Query: 168 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQ 227
L I Q Q + + ++ESR + + E L K E+ T + L+
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLERMKKNLE 1791
Query: 228 KSGEIERRRQESASRYA-----EQISVLKTALLQKEN-IQSSLKRKLQAMR--------- 272
++ + + R + A + A +QI L+ + + EN + KR +A++
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851
Query: 273 -DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
++ E+ K I LQ+ K+QA+ S R QA+ +E+ + + L +
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKR--QAEEAEEQANTQLSRCRRVQHELEE 1909
Query: 332 RKRRELNMKAQALKLAAK 349
R ++Q KL AK
Sbjct: 1910 AAERADIAESQVNKLRAK 1927
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 57.4 bits (137), Expect = 3e-08
Identities = 71/312 (22%), Positives = 138/312 (44%), Gaps = 37/312 (11%)
Query: 141 INNFVKPEKLTKVETRLKEKIVAEMTDLNKH----IKQAQTQRKQLLEESRELHREKLLV 196
I N K K E + ++ + +L K +K+A K L+ +L EKL
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
Query: 197 QAENRFFLEYLTNKTEEYTEQPEKVWNS-------YLQKSGEIERRRQESASRYAEQISV 249
Q N LE LT++ E+ E++ + Y ++E ++S E+I+
Sbjct: 919 QQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 250 LKTALLQKENIQSSLKRKLQAMR-DIAILKEKQEKE--IQT---LQEETKKVQAETASKT 303
L+ L + N L+++L+ ++ + LK++Q++E +Q+ + E K + E+ T
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT 1037
Query: 304 REV-------------QAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKR 350
RE+ A L EK+ L+ QL + + + + + L ++ Q + L +
Sbjct: 1038 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN-NNLQAQILALQRQTVSLQEQN 1096
Query: 351 FIFE-YSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL----ESLI 405
+ + + EN + L+ Q +L QS LEN + + +E+ L +SLI
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156
Query: 406 QARQRLQGSHNQ 417
+ ++L+ H +
Sbjct: 1157 KDHEKLELLHER 1168
Score = 54.7 bits (130), Expect = 2e-07
Identities = 63/261 (24%), Positives = 118/261 (45%), Gaps = 30/261 (11%)
Query: 154 ETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEE 213
E R+K+ I E L++ IK+ ++ ++ E R++ +E LE+ K E
Sbjct: 579 EARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKE-----------LEHYKEKGER 626
Query: 214 YTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRD 273
E ++ +L+K E+ +++ + E+I L+ + E LK+ L + ++
Sbjct: 627 AEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
Query: 274 IAILKEKQEKEIQTLQEETKKVQ--AETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGK 331
+ E EKE L EE +++ E+ AQL E + LE SE ++ G
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE---SEKEQLKKGL 741
Query: 332 RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRK 391
+ K + L+++ + G++ ENQ+ +K L ++ Q+L + LE
Sbjct: 742 ELLKASFKKTERLEVSYQ--------GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 392 QQLQQEQWYLESLIQARQRLQ 412
Q LQ+ LE L + +RL+
Sbjct: 794 QTLQKN---LEELKISSKRLE 811
Score = 47.4 bits (111), Expect = 3e-05
Identities = 67/284 (23%), Positives = 131/284 (46%), Gaps = 24/284 (8%)
Query: 131 RRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELH 190
R+L S N + E L K ++L E+ + E+ + +K A + QL E++EL
Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEENL-ELRRNVESLKCASMKMAQLQLENKELE 731
Query: 191 REKLLVQAENRFFLEYLTNKTE--EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQIS 248
EK ++ + L+ KTE E + Q + N LQK+ E ++ I
Sbjct: 732 SEKEQLK-KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK----------IQ 780
Query: 249 VLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA 308
L++ L E +L++ L+ ++ + E+ EKE ++L++ET +++ + +
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD--------KK 832
Query: 309 QLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKK 368
QL +E + L +Q D L + + N++ + L+ + I++ SC +E ++ K
Sbjct: 833 QLEKENKRLRQQAEIKD-TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 369 ELLQLIE-QAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRL 411
EL++ + L + L + K + QQ LE L +++
Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Score = 45.1 bits (105), Expect = 1e-04
Identities = 56/289 (19%), Positives = 129/289 (44%), Gaps = 39/289 (13%)
Query: 152 KVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKT 211
++E + K + E+ + N ++ AQ KQ ++ES L E LE ++ +T
Sbjct: 395 EMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWE-----------LEQIS-RT 439
Query: 212 EEYTEQPEKVWNSYLQK--SGEIERRRQESASRYAEQISVLKTA----------LLQKEN 259
E +E P+K + + S + + E+ S + + L+T +L+ E
Sbjct: 440 SELSEAPQKSLGHEVNELTSSRLLKLEMENQS-LTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 260 IQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEK 319
L +K++ + + + +++ + Q L ++ K +A+ ++ ++ ++LE+
Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 320 QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYS--------CGINRENQQFKKEL- 370
+ ++ + R+R +++ +A+ + + I S I E +Q KKEL
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 371 --LQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQ 417
+ E+A++L HLE + LQ++ L+ + + L+ +++
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Score = 44.3 bits (103), Expect = 2e-04
Identities = 52/272 (19%), Positives = 121/272 (44%), Gaps = 25/272 (9%)
Query: 71 EHRTNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSCRDLQDECLDSRCKFAEGP 130
+ +T L+E +T ++ + QV +++ +S + +L ++ +Q L++ +
Sbjct: 1086 QRQTVSLQEQNTTLQ-TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 131 RRLLPP-YHSLINNFVKPEKLTKVETRLKEKIVA--------------EMTDLNKHIKQA 175
R L Y SLI + K E L + + E +++ E DL Q
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 176 QTQRKQL--LEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 233
Q+ QL LE+ ++ +EK+L++ +N E + + ++ + +++ ++Y Q E E
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNH---ETVAAEYKKLCGENDRLNHTYSQLLKETE 1261
Query: 234 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK 293
+ + + S+L + L++ +++ + + + + I K + + L +
Sbjct: 1262 VLQTD----HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317
Query: 294 KVQAETASKTREVQAQLLQEKRLLEKQLSEPD 325
++ E ++Q +LQ + LLE+ + D
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 57.4 bits (137), Expect = 3e-08
Identities = 62/244 (25%), Positives = 111/244 (45%), Gaps = 27/244 (11%)
Query: 156 RLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYT 215
+ EK++A LN + Q K L + REL K V +E + L+NK E+
Sbjct: 264 KTNEKLIAH---LNIQVDFLQQANKDLEKRIRELMETKETVTSE----VVNLSNKNEKLC 316
Query: 216 EQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIA 275
++ ++ Q + ++ER ++E VL+TA + + +KRKL M+D+
Sbjct: 317 QELTEID----QLAQQLERHKEE----------VLETADKELGEAKKEIKRKLSEMQDLE 362
Query: 276 ILKEKQEKEIQTLQEETKKVQAETASKT--REVQAQLLQEKRLLEKQLSE---PDRRLLG 330
K + E+ Q+E +++ E K+ V QL QEK+ L K++ +R+L
Sbjct: 363 ETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLEQEKQRLSKKVESFAVTERQLTL 422
Query: 331 KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENR 390
+ +R L + + R + + GI E +KKEL +L Q+ + + S+
Sbjct: 423 EVERMRLEHGIKRRDRSPSR-LDTFLKGIEEERDYYKKELERLQHIIQRRSCSTSYSARE 481
Query: 391 KQQL 394
K +
Sbjct: 482 KSSI 485
Score = 37.0 bits (84), Expect = 0.036
Identities = 52/280 (18%), Positives = 114/280 (40%), Gaps = 15/280 (5%)
Query: 159 EKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQP 218
E A++ L + I + + EE+ + + ++ E F E + KTE+
Sbjct: 695 ESAQAQIKILEEKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQ 754
Query: 219 EKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQA----MRDI 274
E + N + + + S ++ LK L+ ++ +SL+R+L A + ++
Sbjct: 755 ENLAN-----KEKAVAQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV 809
Query: 275 AILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRL---LEKQLSEPDR--RLL 329
+E KE + LQ++ + E + E++A + +++ + + K ++E R L+
Sbjct: 810 GRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLM 869
Query: 330 GKRKRRELNMKAQALKLAAKRFIFEYSC-GINRENQQFKKELLQLIEQAQKLTATQSHLE 388
+++ ++ + L + +E E+ + ELL + + + L LE
Sbjct: 870 AAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLE 929
Query: 389 NRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTT 428
Q+ ES I + + + L Q+ K T
Sbjct: 930 KEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDEKAT 969
Score = 29.3 bits (64), Expect = 7.5
Identities = 35/183 (19%), Positives = 83/183 (45%), Gaps = 21/183 (11%)
Query: 231 EIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQE 290
E R +E+ Y E + + + + + +++SLK+ + D+ L + +++ L++
Sbjct: 74 ENARLSRENNELYLELMKLREHSDQHVKELKTSLKKCARETADLKFLNNQYAHKLKLLEK 133
Query: 291 ETKKVQAETASKTREVQAQLLQEKRL--LEKQLSEPDRRLLGKRKRRELNMKAQALKLAA 348
E SK + + Q LQEK L + + R + +R+R +++ ++++
Sbjct: 134 E---------SKAKNERIQQLQEKNLHAVVQTPGGKKRSIAFRRQRMQIDEPVPPSEVSS 184
Query: 349 -------KRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYL 401
+I + + Q+ ++E+ QL E KL +S + + +Q++ + +
Sbjct: 185 YPVPQPDDPYIADLLQVADNRIQELQQEVHQLQE---KLAMMESGVRDYSKQIELREREI 241
Query: 402 ESL 404
E L
Sbjct: 242 ERL 244
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/321 (25%), Positives = 140/321 (43%), Gaps = 61/321 (19%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFF-LEY 206
+ L +L +++ DLN+ I +Q+KQLLE + ++E EN++ LE
Sbjct: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE-----LENKYAKLEE 2574
Query: 207 LTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENI---QSS 263
++EE E + +N+ LQ+ + + ES Q++ TAL ++ + +
Sbjct: 2575 KLKESEEANEDLRRSFNA-LQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
Query: 264 LKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLL------ 317
LK K + + ++ L +K I L+EE VQ E A K E++ +L +E + L
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGI 2693
Query: 318 --------EKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCG--------INR 361
E++++E R L+ + +++ L + + L A+ F S N
Sbjct: 2694 MRNETETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752
Query: 362 ENQQFK-------KELLQLIEQ--------------AQKLTATQ----SHLENRKQQLQQ 396
E + K KEL QL EQ A + +T+ SHLE QQL
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 397 EQWYLESLIQARQRLQGSHNQ 417
+ E L+ +L+ S+NQ
Sbjct: 2813 KD---EQLLHLSSQLEDSYNQ 2830
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/290 (22%), Positives = 126/290 (43%), Gaps = 32/290 (11%)
Query: 108 ELHSCRDLQDECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIVAEMTD 167
EL L++ + + E L + I N+ + +++ L E +EM +
Sbjct: 1904 ELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE---SEMKN 1960
Query: 168 LNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPE-KVWNSYL 226
L K + + + +++QL++E ++ E ++ E +LE + +E + K L
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESE---IRKE---YLEKIQGAQKEPGNKSHAKELQELL 2014
Query: 227 QKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQ 286
++ + ++ Q+ RY E+IS L+ + E +Q+ ++ +D+ I KE + +
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT------ESQKDLEITKENLAQAV- 2067
Query: 287 TLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRK-RRELNMKAQALK 345
E KK QAE AS K LL+ SE R L K ++EL +++K
Sbjct: 2068 ---EHRKKAQAELAS-----------FKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Query: 346 LAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQ 395
K+ + + + ++ KE + E+ L + HLE ++Q
Sbjct: 2114 SQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ 2163
Score = 50.4 bits (119), Expect = 3e-06
Identities = 72/341 (21%), Positives = 146/341 (42%), Gaps = 54/341 (15%)
Query: 97 ASAHSLAVTLSELHSCRDLQ----DECLDSRCKFAEGPRRLLPPYHSLINNFVKPEKLTK 152
A A L V L ++ +D+Q DE L K A+ K+ K
Sbjct: 55 AYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADN-------------------KIKK 95
Query: 153 VETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTE 212
++ K A++T LNK+I++ + Q +L + E+L ++ E K +
Sbjct: 96 LKLHAK----AKLTSLNKYIEEMKAQGGTVLPTEPQ-SEEQLSKHDKSSTEEEMEIEKIK 150
Query: 213 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKL-QAM 271
++ E++ ++ + + + + +S E+ ++K L +KE S+L+ +L Q
Sbjct: 151 HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210
Query: 272 RDIA---ILKEKQEK-EIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRR 327
+ A +++EK + E Q E + +Q T + +V+ ++ Q+ R+L+++L E +
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQA---DVETEMQQKLRVLQRKLEEHEES 267
Query: 328 LLGK-------------RKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLI 374
L+G+ ++R + Q ++ A+ + RE + E ++L
Sbjct: 268 LVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE 327
Query: 375 EQAQKLT-----ATQSHLENRKQQLQQEQWYLESLIQARQR 410
+KL+ HL + +Q Q Q LES A ++
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ 368
Score = 47.4 bits (111), Expect = 3e-05
Identities = 61/278 (21%), Positives = 120/278 (43%), Gaps = 48/278 (17%)
Query: 172 IKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGE 231
+++ +QL+ E +++ R+K + + +E ++ K ++ ++K
Sbjct: 50 VQERLAYAEQLVVELKDIIRQK-----------DVQLQQKDEALQEERKAADNKIKKLKL 98
Query: 232 IERRRQESASRYAEQI-----SVLKTALLQKENIQSSLKRKLQAMRDIAILKEK-QEKE- 284
+ + S ++Y E++ +VL T +E + K + +I +K K QEKE
Sbjct: 99 HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 285 -IQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQA 343
I TLQ + + QAE +++ + ++E ++++QL E + + + +
Sbjct: 159 LISTLQAQLTQAQAEQPAQS----STEMEEFVMMKQQLQEKEEFI----STLQAQLSQTQ 210
Query: 344 LKLAAKRFIFEYSCGINRENQQFKKELLQLIEQA-------QKLTATQSHLENRKQQ--- 393
+ AA++ + E + + + ELLQL+ QA QKL Q LE ++
Sbjct: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Query: 394 -------LQQEQWYLES----LIQARQRLQGSHNQCLN 420
LQQE E L Q Q+++ HN N
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRN 308
Score = 44.7 bits (104), Expect = 2e-04
Identities = 66/320 (20%), Positives = 136/320 (42%), Gaps = 60/320 (18%)
Query: 139 SLINNFVKPEKLTKVETRLKEKIVAE-MTDLNKHIKQAQTQR---KQLLEESRELHREKL 194
S + VK + + E++ +I E + +H K+AQ + K LL++++ E
Sbjct: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS---EAA 2092
Query: 195 LVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTAL 254
V A+N +E E V + QK ++ERR +++ ++ ++ ++ L
Sbjct: 2093 RVLADN-------LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 255 --LQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQA---- 308
L++E + + + +I + K++KE+Q LQE + A+ T+ + +
Sbjct: 2146 DALRREKVHLE-----ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 309 --QLLQEKRLLEKQLSE------------PDRRLLGKRKRRELNMKAQALKLAAKRF--- 351
+++ E + E++ S+ D + K + R++++ + LK+ R
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 352 --IFEYSCGINRENQQ--------FKKELLQLIEQAQ--------KLTATQSHLENRKQQ 393
I+E + QQ KELL +E+ + +L +S L++ K Q
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320
Query: 394 LQQEQWYLESLIQARQRLQG 413
L LE + + L+G
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEG 2340
Score = 43.9 bits (102), Expect = 3e-04
Identities = 54/251 (21%), Positives = 114/251 (45%), Gaps = 30/251 (11%)
Query: 146 KPEKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLE 205
KPE++ + E+R K++I + ++ A RK+ L+E++ L E L + +
Sbjct: 1467 KPEEIGE-ESRAKQQI-------QRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
Query: 206 YLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLK 265
L + + + Q K ++ L + ++ R + I+ + +LL+ +++ SS +
Sbjct: 1519 SLADVESQVSAQ-NKEKDTVLGRLALLQEERDKL-------ITEMDRSLLENQSLSSSCE 1570
Query: 266 RKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQ---LLQEKRLLEKQ-- 320
A+ + KEK KEI++L+ E K +E+Q + LLQ + +
Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Query: 321 --------LSEPDRRLLGKRKRRELNMKAQALKL-AAKRFIFEYSCGINRENQQFKKELL 371
+ + + L GK + E N K +L A++ + E + + + ++++L
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Query: 372 QLIEQAQKLTA 382
+L E+ +L A
Sbjct: 1691 ELEEENDRLRA 1701
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/240 (21%), Positives = 112/240 (46%), Gaps = 25/240 (10%)
Query: 174 QAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIE 233
Q T Q+ + +E+ EK+ ++ + +++ T E T++ E+V+
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELK-------VSSTTSELTKKSEEVF----------- 1340
Query: 234 RRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETK 293
+ QE ++ +I LKT + E SL++KL++ + + I + +E+Q +E +
Sbjct: 1341 -QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ-LQIAGLEHLRELQPKLDELQ 1398
Query: 294 KVQAETASKTREVQAQLLQEKRLLEK-QLSEPDRRLLGKRKRRELNMKAQALKLAAKRFI 352
K+ ++ + QL +++ L K Q ++ L K +L M+A+ K+
Sbjct: 1399 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 353 FEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQ 412
E C + ++ ++ +E + +KL Q+ L +RK+ L++ + E L AR ++
Sbjct: 1459 VEL-CEMKQKPEEIGEESRAKQQIQRKL---QAALISRKEALKENKSLQEELSLARGTIE 1514
Score = 38.1 bits (87), Expect = 0.016
Identities = 68/302 (22%), Positives = 127/302 (42%), Gaps = 42/302 (13%)
Query: 74 TNKLRELSTLAHCSRELQTQVPDASAHSLAVTLSELHSC-RDLQDECLDSRCKFAEGPRR 132
T ++ LS A S++++ +V + + SE + R LQ + + + EG R
Sbjct: 795 TEQIHSLSIEAK-SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 133 ---LLPPYHSLINNFVKPE-KLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQL----LE 184
+ L + E ++TK++ L EK ++ L + I++ Q ++ E
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEK-KRDVETLQQTIEEKDQQVTEISFSMTE 912
Query: 185 ESRELHREKLLVQAENRFFLEYLT------NKTEEYTEQPEKVWNSYLQKSGEIERRRQE 238
+ +L+ EK + E + E L +E E+ +V + Q E+ Q
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQI 972
Query: 239 SASRYAEQISVLKTALLQKENIQSSLKRKLQAM---------------RDIAILKEKQEK 283
S + +LK KEN Q KRKLQA ++A LK++ +K
Sbjct: 973 SKEELQHEFDLLK-----KENEQR--KRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 284 EIQTLQEETKKVQAETASK---TREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMK 340
EI + E +V+ + +K + V ++ + + L++ +SE + L RK E +
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 341 AQ 342
A+
Sbjct: 1086 AE 1087
Score = 38.1 bits (87), Expect = 0.016
Identities = 72/337 (21%), Positives = 130/337 (38%), Gaps = 52/337 (15%)
Query: 107 SELHSCRDLQDECLD----SRCKFAEGPRRLLPPYHSLINNFVKPEKLTKVETRLKEKIV 162
+E+H D EC++ S E R+ Y +L F + L + L E
Sbjct: 1701 AEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF---QSLMSEKDSLSE--- 1754
Query: 163 AEMTDLNKHIKQAQTQRKQLLEESRELHREKLLV----------QAENRFFLEYLTNKTE 212
E+ DL I+ +++ L E+ E H + V + E + L T T
Sbjct: 1755 -EVQDLKHQIEGNVSKQANL--EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811
Query: 213 EYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 272
+ K N + K + + + Y +QI LK + E + K Q +
Sbjct: 1812 SESVPSAKSANPAVSK----DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867
Query: 273 DI--AILKEKQEK--EIQTLQEETKKVQA------ETASKTREVQAQLLQEKRLLEKQLS 322
+ +L + K E++ LQEE K+ E S+ +++ +EK LE++L
Sbjct: 1868 NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM 1927
Query: 323 EPDRRLLG------------KRKRRELNMKAQALKLAAKRFIFEYSCGINRENQ---QFK 367
L G + K L + + LK E + + + + +
Sbjct: 1928 NQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 368 KELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESL 404
KE L+ I+ AQK +SH + ++ L+++Q ++ L
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Score = 35.0 bits (79), Expect = 0.14
Identities = 39/190 (20%), Positives = 71/190 (37%), Gaps = 21/190 (11%)
Query: 148 EKLTKVETRLKEKIVAEMTDLNKHIKQAQTQRKQLLE---------------------ES 186
EKL K LK +AE T+ + K+ Q + + LL+ E
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
Query: 187 RELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQ 246
+EL+ + +A + + L +E E EK+ K +I +E+ AE
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 247 ISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREV 306
TA E + SS + + + + E K+ Q+L E + E ++
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 307 QAQLLQEKRL 316
+ + ++ L
Sbjct: 1764 EGNVSKQANL 1773
Score = 32.0 bits (71), Expect = 1.2
Identities = 29/177 (16%), Positives = 77/177 (43%), Gaps = 14/177 (7%)
Query: 161 IVAEMTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEK 220
+ ++ ++ ++KQ ++++ L+ R+ EKL + + + ++ + ++ T Q +
Sbjct: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 221 VWNSYLQKSGEIER--------RRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMR 272
+ + I++ +S + E + + E+ + L+ K+ A+
Sbjct: 1111 LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE 1170
Query: 273 DIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEK---RLLEKQLSEPDR 326
KE+ +K++Q K + + K R ++ +L Q+K L++Q E +
Sbjct: 1171 KE---KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
Score = 29.3 bits (64), Expect = 7.5
Identities = 48/227 (21%), Positives = 98/227 (43%), Gaps = 35/227 (15%)
Query: 189 LHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQIS 248
+ +E+ + ++R E N + ++ + L +I + Q+ R QI
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694
Query: 249 VLKTALLQKENI-QSSLKRKLQAMRDIAILKEKQEKEIQT-------LQEETKKV--QAE 298
L+ + + I + +L K + + ++ L E+ +K L EE ++ Q +
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 299 TASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFE--YS 356
S E++AQ+ Q LE L+E +R+ R L+ ++Q A + E +S
Sbjct: 755 ELSMVTELRAQVKQ----LEMNLAEAERQ-------RRLDYESQT---AHDNLLTEQIHS 800
Query: 357 CGINRENQQFKKELLQ---------LIEQAQKLTATQSHLENRKQQL 394
I +++ K E+LQ EQ+ + + QS L+N++ ++
Sbjct: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV 847
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,182,351
Number of Sequences: 37866
Number of extensions: 750999
Number of successful extensions: 8536
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 237
Number of HSP's successfully gapped in prelim test: 896
Number of HSP's that attempted gapping in prelim test: 4436
Number of HSP's gapped (non-prelim): 3012
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.