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Search of human proteins with 217416392
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217416392 pleckstrin homology domain containing, family H
(with MyTH4 domain) member 2 [Homo sapiens]
(1493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217416392 pleckstrin homology domain containing, family H (wi... 2986 0.0
gi|55741447 pleckstrin homology domain containing, family H (wit... 1174 0.0
gi|154354979 myosin X [Homo sapiens] 105 3e-22
gi|189083802 myosin VIIA isoform 2 [Homo sapiens] 81 7e-15
gi|189083798 myosin VIIA isoform 1 [Homo sapiens] 81 7e-15
gi|122937512 myosin VIIB [Homo sapiens] 74 8e-13
gi|40255047 pleckstrin homology domain containing, family H (wit... 68 8e-11
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 62 5e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 59 4e-08
gi|154146216 pleckstrin homology domain containing, family A (ph... 59 5e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 58 6e-08
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [... 57 1e-07
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [... 57 1e-07
gi|21735582 oxysterol-binding protein-like protein 3 isoform c [... 57 1e-07
gi|21735580 oxysterol-binding protein-like protein 3 isoform b [... 57 1e-07
gi|14149704 oxysterol-binding protein-like protein 3 isoform a [... 57 1e-07
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 57 1e-07
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 57 1e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 57 2e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 57 2e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 57 2e-07
gi|50234893 pleckstrin homology domain containing, family A (pho... 56 2e-07
gi|31377720 pleckstrin homology domain containing, family A (pho... 56 2e-07
gi|169208517 PREDICTED: similar to Golgin subfamily A member 8-l... 55 4e-07
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 55 5e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 55 7e-07
gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein... 54 9e-07
gi|4505531 oxysterol binding protein [Homo sapiens] 54 1e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 54 1e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 1e-06
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 2986 bits (7742), Expect = 0.0
Identities = 1493/1493 (100%), Positives = 1493/1493 (100%)
Query: 1 MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF 60
MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF
Sbjct: 1 MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF 60
Query: 61 QQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA 120
QQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA
Sbjct: 61 QQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA 120
Query: 121 KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL 180
KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL
Sbjct: 121 KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL 180
Query: 181 KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN 240
KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN
Sbjct: 181 KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN 240
Query: 241 QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS 300
QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS
Sbjct: 241 QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS 300
Query: 301 RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQW 360
RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQW
Sbjct: 301 RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQW 360
Query: 361 KALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHP 420
KALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHP
Sbjct: 361 KALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHP 420
Query: 421 NSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIR 480
NSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIR
Sbjct: 421 NSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIR 480
Query: 481 PLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPP 540
PLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPP
Sbjct: 481 PLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPP 540
Query: 541 TPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTP 600
TPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTP
Sbjct: 541 TPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTP 600
Query: 601 VYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLS 660
VYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLS
Sbjct: 601 VYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLS 660
Query: 661 SVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSW 720
SVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSW
Sbjct: 661 SVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSW 720
Query: 721 KRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTAD 780
KRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTAD
Sbjct: 721 KRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTAD 780
Query: 781 SPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYY 840
SPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYY
Sbjct: 781 SPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYY 840
Query: 841 FRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLL 900
FRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLL
Sbjct: 841 FRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLL 900
Query: 901 IGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGI 960
IGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGI
Sbjct: 901 IGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGI 960
Query: 961 ISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI 1020
ISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI
Sbjct: 961 ISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI 1020
Query: 1021 CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKY 1080
CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKY
Sbjct: 1021 CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKY 1080
Query: 1081 AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS 1140
AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS
Sbjct: 1081 AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS 1140
Query: 1141 TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ 1200
TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ
Sbjct: 1141 TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ 1200
Query: 1201 QPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA 1260
QPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA
Sbjct: 1201 QPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA 1260
Query: 1261 ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL 1320
ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL
Sbjct: 1261 ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL 1320
Query: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL 1380
STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL
Sbjct: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL 1380
Query: 1381 LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLI 1440
LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLI
Sbjct: 1381 LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLI 1440
Query: 1441 ASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL 1493
ASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL
Sbjct: 1441 ASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL 1493
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 1174 bits (3038), Expect = 0.0
Identities = 609/1080 (56%), Positives = 780/1080 (72%), Gaps = 39/1080 (3%)
Query: 432 PSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSD---RMFGTNRNAISMIRPLRPQETD 488
P S L PK+R P S+ LAKRH SQPQ+ R+ A S + P E +
Sbjct: 306 PGSSLTLPKVRAPGTPRDSIQLAKRHHSQPQVGHGHFGRVVNIETEAFSALHPSGLPELE 365
Query: 489 LDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAY-SKPPTPPLHRF 547
S E E M+ + +SP + E ++V +KPPTPPLH+F
Sbjct: 366 SR---ARSREEPEKMEMEEPPPAGKNEERESPKALGAE----LEEVELGNKPPTPPLHQF 418
Query: 548 PSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKG 607
SWESRIYAVA SG+R+S+ + +++ + + G ++ L+YKN+T PVYT LKG
Sbjct: 419 SSWESRIYAVATSGMRLSDMSPRSNTACCASSPPALVSPGSFSGLVYKNVTVPVYTALKG 478
Query: 608 KATQISSSPFLDDSSGSEEEDSSRSSSRTS--ESDSRSRSGPGSPRAMKRGVSLSSVASE 665
+ATQIS+ PF+D+SSGS+++ SS++S R S S+SR SG GSPRA+KRGVS+SS++SE
Sbjct: 479 RATQISNMPFMDESSGSDDDCSSQASFRISVPSSESRKTSGLGSPRAIKRGVSMSSLSSE 538
Query: 666 SDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGK--NEPLEKSGYLLKMSGKVKSWKRR 723
DYAIPPDA S D++YS+PE KL +T S S+D E LEKSGYLLKM +VK+WKRR
Sbjct: 539 GDYAIPPDACSLDSDYSEPEHKLQRTSSYSTDGLGLGGESLEKSGYLLKMGSQVKTWKRR 598
Query: 724 WFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPN 783
WFVL+ G+++YYKSPSDVIRKPQG ++L++ C I+RG+ QT QL +EK TYYLTADSP+
Sbjct: 599 WFVLRQGQIMYYKSPSDVIRKPQGQVDLNSRCQIVRGEGSQTFQLISEKKTYYLTADSPS 658
Query: 784 ILEEWIKVLQNVLRVQAANPLSLQPEG-KPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFR 842
+LEEWI+VLQ++L+VQA P +L G KPT+KG LTKVKHG+SK VWC L+GK YY+R
Sbjct: 659 LLEEWIRVLQSLLKVQATGPPALLRGGTKPTVKGWLTKVKHGHSKVVWCALVGKIFYYYR 718
Query: 843 SQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASG-RSLLSTHYTIVIHPKDQGPTYLLI 901
S EDK PLG + + +A +EEVDRSCDSDEDYEA G R LLS+H T+VIHP + PTYLLI
Sbjct: 719 SHEDKRPLGCLPVRDAHIEEVDRSCDSDEDYEAGGTRRLLSSHCTLVIHPTEHSPTYLLI 778
Query: 902 GSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGII 961
G+KHEKDTWLYHLTVAAG ++ VG+ +EQL+ KL++ +G+P S +WRHP LC+SK+G+
Sbjct: 779 GTKHEKDTWLYHLTVAAGGSSAKVGTAYEQLIGKLMDGEGDPDSPLWRHPMLCYSKDGLY 838
Query: 962 SPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEIC 1021
+ LTTLPSEALQTEA+KLFK+CQLFIN V++ ++DYH+SLAQ+ALQ+CL HPELQ+EI
Sbjct: 839 ASLTTLPSEALQTEALKLFKSCQLFINVPVEAASVDYHVSLAQTALQVCLVHPELQSEIY 898
Query: 1022 CQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYA 1081
CQL+KQT R PQ +Q WQLLALC LFLP H FLW ++ L+R+AD R+E G+YA
Sbjct: 899 CQLMKQTSCRPPQKY-SLMQCWQLLALCAPLFLPQHHFLWYVKQQLQRHADPRSETGQYA 957
Query: 1082 IYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAST 1141
YCQR VERT + G+REARPSRME++S LLRNP+HHSLPFSIPVHF NG Y VVGFD S+
Sbjct: 958 TYCQRAVERTLRTGEREARPSRMEVVSILLRNPFHHSLPFSIPVHFTNGTYHVVGFDGSS 1017
Query: 1142 TVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQ 1201
TV+EFL LNQ+ GMRKP+ SGFALFTDDPSGRDLEHCLQG++KICD ISKWEQA KE
Sbjct: 1018 TVDEFLQRLNQEIGMRKPSHSGFALFTDDPSGRDLEHCLQGSVKICDAISKWEQAMKELH 1077
Query: 1202 PGKCE-GTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA 1260
PGK E GTR V+L YKNRLYF Q +GETDRE+LLL QT+ +I+ G FP+NK+LALEMA
Sbjct: 1078 PGKSEGGTRVVKLMYKNRLYFRSQVKGETDRERLLLASQTSREIVAGRFPINKELALEMA 1137
Query: 1261 ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL 1320
AL++QVE GD E+P + P T+ K L+QV+++F+P+RYR G EQLR L L
Sbjct: 1138 ALMAQVEYGDLEKP-ALPGPGGTSPAKAQHLLQQVLDRFHPRRYRHGAPAEQLRHLADML 1196
Query: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL 1380
+T+W L+G S +C+RIYLTVARKWPFFGAKLF A+P SS + +W+AV+EDG+S+
Sbjct: 1197 TTKWATLQGCSPPECIRIYLTVARKWPFFGAKLFAAQPAQLSSKENALVWIAVNEDGVSI 1256
Query: 1381 LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKD---KPTEKLLFAMAKPKILEIT 1437
L++N+M++ ++Y Y S+ TFGG +DDFM+VI + K EKL+F MA PKI E T
Sbjct: 1257 LDHNTMQVHITYPYSSVTTFGGCRDDFMLVIRSIPDKSSGKSHIEKLIFRMAAPKIAEAT 1316
Query: 1438 LLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQA----RMMGSQPLLSSSRPTKGPTLL 1493
++ASY+N+ ++ T P A + G Q S S TKGPTLL
Sbjct: 1317 FIMASYMNH------------CTTTVNPPTNPPGACQLWELDGRQFFSSVSCATKGPTLL 1364
Score = 181 bits (459), Expect = 5e-45
Identities = 91/171 (53%), Positives = 133/171 (77%), Gaps = 1/171 (0%)
Query: 1 MAELS-EPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKA 59
MAEL E VDW++RC+ LE+QL +FR+QASKIRELLA+KMQ+LE+++++AE++AE A
Sbjct: 1 MAELKVEAPASVDWQKRCLTLETQLFRFRLQASKIRELLADKMQELEQRLLEAEQRAENA 60
Query: 60 FQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQE 119
QV VME+K+K +N++ +SE L+ K Q+L I+ KD++I LE QLE+QKQ+R +E
Sbjct: 61 ETQVGVMEEKVKLSNLKNVDSEGSLHRKYQELLKAIKGKDELISQLEAQLEKQKQMRAEE 120
Query: 120 AKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQ 170
AK ++EKAAKIKEWVT+KL +LE+ENQ+L+ NQ E++ ++Q L+ +Q
Sbjct: 121 AKTVQEKAAKIKEWVTLKLAKLEMENQHLKSHNQRLVEQVGSLQDALEAIQ 171
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 105 bits (262), Expect = 3e-22
Identities = 167/764 (21%), Positives = 302/764 (39%), Gaps = 132/764 (17%)
Query: 751 LSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNV---LRVQAANP---- 803
+ + C+ D + + T + AD+P + WI +LQ RV+
Sbjct: 1338 IDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQEFIVRG 1397
Query: 804 -LSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFRSQE-DKFPLGQIKLWE-AKV 860
L + + P M L K + W L +L Y++S E + LG + L V
Sbjct: 1398 WLHKEVKNSPKMSSLKLKKR-------WFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSV 1450
Query: 861 EEVDRSCDSDEDY---EASGRSLLSTHYTIVIHPKDQGPTYL--LIGSKHEKDTWLYHLT 915
D + Y GR YT +++ + + + + +K DT L
Sbjct: 1451 VPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLI 1510
Query: 916 VAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGIISPLTTLPS------ 969
N +N S+ + + K R+P L ++ + SPL LP
Sbjct: 1511 QDIKENCLN--SDVVEQIYK-------------RNPILRYTHHPLHSPLLPLPYGDINLN 1555
Query: 970 -------EALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICC 1022
LQ EAIK+F + Q + + P I Q LQ L++E+ C
Sbjct: 1556 LLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPII-------QGILQTGHDLRPLRDELYC 1608
Query: 1023 QLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADS--RTEFGKY 1080
QLIKQT + G L WQ+L FLP L L+ HLKR + +E KY
Sbjct: 1609 QLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKY 1668
Query: 1081 AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS 1140
A++ +++T+ RE PSR EI + + H + V+ G + ++
Sbjct: 1669 ALFTYESLKKTK---CREFVPSRDEIEALI------HRQEMTSTVYCHGGGSCKITINSH 1719
Query: 1141 TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ 1200
TT E + L + M + +++ FALF + +G ++ ++ + D+++K+E+ +
Sbjct: 1720 TTAGEVVEKLIRGLAM-EDSRNMFALF--EYNGH-VDKAIESRTVVADVLAKFEKLAATS 1775
Query: 1201 QPGKCEGTRTVRLTYKNRLYFSVQARGETDR------EKLLLMYQTNDQIINGLFPLNKD 1254
+ G L +K YF + +TD E + Q ++ +I+G P ++
Sbjct: 1776 EVGD--------LPWK--FYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEE 1825
Query: 1255 LALEMAALLSQVEIGDFE-RPFSTPAGHVTNQCKVNQTLKQVIEKFYP------------ 1301
+AAL Q GD+ P V + ++ + Q + F P
Sbjct: 1826 NLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFL 1885
Query: 1302 -----KRYRDG------CSEEQLRQLCQR---------LSTRWMALRGHSAADCVRIYLT 1341
+ +R G EEQ+ + + + +W +G + + Y+
Sbjct: 1886 EGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMA 1945
Query: 1342 VARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFG 1401
+ ++WP +G+ LF + LWL V D +S+ + R + + Y+ +++FG
Sbjct: 1946 LIKEWPGYGSTLFDVE--CKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFG 2003
Query: 1402 GYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLIASYIN 1445
+ NT+ +LLF + +++++ L+ +YI+
Sbjct: 2004 -------APLANTYKIVVDERELLFETS--EVVDVAKLMKAYIS 2038
Score = 55.1 bits (131), Expect = 5e-07
Identities = 32/102 (31%), Positives = 55/102 (53%), Gaps = 9/102 (8%)
Query: 700 KNEPLEKSGYLLKMSG-----KVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSAS 754
K E L K G+L K G ++WK+RWFVL+ +L+Y+++ S+ K +G +E+ +
Sbjct: 1210 KQEAL-KQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSE--EKLKGTVEVRTA 1266
Query: 755 CSILRGDNKQT-VQLTTEKHTYYLTADSPNILEEWIKVLQNV 795
I+ K+ + + T++L A+SP +W VL V
Sbjct: 1267 KEIIDNTTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQV 1308
Score = 45.1 bits (105), Expect = 5e-04
Identities = 47/223 (21%), Positives = 104/223 (46%), Gaps = 17/223 (7%)
Query: 14 KERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAA 73
K+ + + QL + ++ R+LLAEK +Q E++ + E + ++ ++ + ++ +A
Sbjct: 789 KKAAIVFQKQL-RGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAE 847
Query: 74 NIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIR-IQEAKIIEEKAAKIKE 132
E ETR K Q+LE+L +K L +LE+QK+ + ++E +E++ ++
Sbjct: 848 LRAQQEEETR---KQQELEAL--QKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQR 902
Query: 133 WVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLT 192
+ EL L +L+ + + + +E+R ++ + + +++ ++ E R
Sbjct: 903 --MKEQQELSLTEASLQKLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVR----- 955
Query: 193 FGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPE 235
+ R+ S SE ++P F + E E+ E
Sbjct: 956 ---NIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDE 995
Score = 41.6 bits (96), Expect = 0.006
Identities = 42/178 (23%), Positives = 69/178 (38%), Gaps = 19/178 (10%)
Query: 614 SSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPD 673
SS +S GS+ R S T S G+ R G S SE D+
Sbjct: 1105 SSVTFSNSYGSQWSPDYRCSVGTYNSS-------GAYRFSSEGAQSSFEDSEEDF---DS 1154
Query: 674 AYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSWKRRWFVLKGGELL 733
+ TD E S + + + +L G + SWKRRW VLK L
Sbjct: 1155 RFDTDDELSYRRDSVYSCVTLPYFHS---------FLYMKGGLMNSWKRRWCVLKDETFL 1205
Query: 734 YYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKV 791
+++S + +++ H + S ++ R + K+ + + Y DS L+ ++V
Sbjct: 1206 WFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEV 1263
Score = 41.2 bits (95), Expect = 0.008
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 10/99 (10%)
Query: 711 LKMSGKVKSWK--RRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNK----- 763
+K S K+ S K +RWFVL L YYKS S+ G + L++ CS++ D K
Sbjct: 1403 VKNSPKMSSLKLKKRWFVLTHNSLDYYKS-SEKNALKLGTLVLNSLCSVVPPDEKIFKET 1461
Query: 764 --QTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQA 800
V + KH Y L N W +QNV +A
Sbjct: 1462 GYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKA 1500
>gi|189083802 myosin VIIA isoform 2 [Homo sapiens]
Length = 2175
Score = 81.3 bits (199), Expect = 7e-15
Identities = 70/241 (29%), Positives = 112/241 (46%), Gaps = 30/241 (12%)
Query: 1011 LTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRN 1070
+ P L++EI CQ+ KQ ++ +GW L++LCVG F P F+ LR +
Sbjct: 1162 ILRPALRDEIYCQISKQLTHNPSKSSYA--RGWILVSLCVGCFAPSEKFVKYLRNFIHGG 1219
Query: 1071 ADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNG 1130
YA YC+ + RT NG R PS +E+ +T + P +PV FM+G
Sbjct: 1220 PPG------YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDG 1267
Query: 1131 IYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFT---DDPSGRDLEHCLQGNIKIC 1187
+ + D++TT +E N L ++ + GF+L+ D S G+ +
Sbjct: 1268 TTKTLLTDSATTAKELCNALADKISLKD--RFGFSLYIALFDKVSSLG-----SGSDHVM 1320
Query: 1188 DIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIING 1247
D IS+ EQ +KEQ G E RL ++ ++ + E D L+YQ Q++ G
Sbjct: 1321 DAISQCEQYAKEQ--GAQERNAPWRLFFRKEVFTPWHSPSE-DNVATNLIYQ---QVVRG 1374
Query: 1248 L 1248
+
Sbjct: 1375 V 1375
Score = 61.6 bits (148), Expect = 5e-09
Identities = 100/484 (20%), Positives = 195/484 (40%), Gaps = 71/484 (14%)
Query: 946 QIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQS 1005
++W H T K+ ++ L L SE L EA C FI AV DY +S
Sbjct: 1705 RLWSH-TREPLKQALLKKL--LGSEELSQEA------CLAFI--AVLKYMGDYPSKRTRS 1753
Query: 1006 ALQIC-------LTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHP 1058
++ L L++E Q++KQ + +GW+LL LC GLF P +
Sbjct: 1754 VNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIRYSEE--RGWELLWLCTGLFPPSN- 1810
Query: 1059 FLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHS 1118
+L H++R SR + AI C + +++ +NG R+ P +E+ + H +
Sbjct: 1811 ---ILLPHVQRFLQSR-KHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAI-----QHKT 1861
Query: 1119 LPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEH 1178
V+F + + ++ST ++F N T + + GF+LF D
Sbjct: 1862 TQIFHKVYFPDDTDEAFEVESSTKAKDFCQ--NIATRLLLKSSEGFSLFV---KIADKVL 1916
Query: 1179 CLQGNIKICDIISKWEQASKEQQPGK--CEGTRTVRLTYKNRLYFSVQARGETDREKLLL 1236
+ N D + K+ +P K + T ++ + +L+ + + + +
Sbjct: 1917 SVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFH 1976
Query: 1237 MYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVI 1296
YQ + + G ++ L++ AL+ +V+ + + F +
Sbjct: 1977 YYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPS------------------- 2017
Query: 1297 EKFYPKRYRDGCSEEQLRQLC-----QRLSTRWMALRGHSAADCVRIYLTVARKWPFFGA 1351
PK R+ ++ +RQ+ + + + G S + +L + KWP FG+
Sbjct: 2018 ---IPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGS 2074
Query: 1352 KLF--LAKPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMV 1409
F +P P L +A+++ G+SL++ + ++ ++ + + + F +
Sbjct: 2075 AFFEQTTEPNFPE-----ILLIAINKYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHI 2129
Query: 1410 VINN 1413
I N
Sbjct: 2130 TIGN 2133
>gi|189083798 myosin VIIA isoform 1 [Homo sapiens]
Length = 2215
Score = 81.3 bits (199), Expect = 7e-15
Identities = 70/241 (29%), Positives = 112/241 (46%), Gaps = 30/241 (12%)
Query: 1011 LTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRN 1070
+ P L++EI CQ+ KQ ++ +GW L++LCVG F P F+ LR +
Sbjct: 1162 ILRPALRDEIYCQISKQLTHNPSKSSYA--RGWILVSLCVGCFAPSEKFVKYLRNFIHGG 1219
Query: 1071 ADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNG 1130
YA YC+ + RT NG R PS +E+ +T + P +PV FM+G
Sbjct: 1220 PPG------YAPYCEERLRRTFVNGTRTQPPSWLELQATKSKK------PIMLPVTFMDG 1267
Query: 1131 IYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFT---DDPSGRDLEHCLQGNIKIC 1187
+ + D++TT +E N L ++ + GF+L+ D S G+ +
Sbjct: 1268 TTKTLLTDSATTAKELCNALADKISLKD--RFGFSLYIALFDKVSSLG-----SGSDHVM 1320
Query: 1188 DIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIING 1247
D IS+ EQ +KEQ G E RL ++ ++ + E D L+YQ Q++ G
Sbjct: 1321 DAISQCEQYAKEQ--GAQERNAPWRLFFRKEVFTPWHSPSE-DNVATNLIYQ---QVVRG 1374
Query: 1248 L 1248
+
Sbjct: 1375 V 1375
Score = 65.9 bits (159), Expect = 3e-10
Identities = 100/482 (20%), Positives = 195/482 (40%), Gaps = 65/482 (13%)
Query: 946 QIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQS 1005
++W H T K+ ++ L L SE L EA C FI AV DY +S
Sbjct: 1743 RLWSH-TREPLKQALLKKL--LGSEELSQEA------CLAFI--AVLKYMGDYPSKRTRS 1791
Query: 1006 ALQIC-------LTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHP 1058
++ L L++E Q++KQ + +GW+LL LC GLF P +
Sbjct: 1792 VNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIRYSEE--RGWELLWLCTGLFPPSN- 1848
Query: 1059 FLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHS 1118
+L H++R SR + AI C + +++ +NG R+ P +E+ + H +
Sbjct: 1849 ---ILLPHVQRFLQSR-KHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAI-----QHKT 1899
Query: 1119 LPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEH 1178
V+F + + ++ST ++F N T + + GF+LF D
Sbjct: 1900 TQIFHKVYFPDDTDEAFEVESSTKAKDFCQ--NIATRLLLKSSEGFSLFV---KIADKVL 1954
Query: 1179 CLQGNIKICDIISKWEQASKEQQPGK--CEGTRTVRLTYKNRLYFSVQARGETDREKLLL 1236
+ N D + K+ +P K + T ++ + +L+ + + + +
Sbjct: 1955 SVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFH 2014
Query: 1237 MYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVI 1296
YQ + + G ++ L++ AL+ +V+ + + F +
Sbjct: 2015 YYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPS------------------- 2055
Query: 1297 EKFYPKRYRDGCSEEQLRQLC-----QRLSTRWMALRGHSAADCVRIYLTVARKWPFFGA 1351
PK R+ ++ +RQ+ + + + G S + +L + KWP FG+
Sbjct: 2056 ---IPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGS 2112
Query: 1352 KLFLAKPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVI 1411
F K T + L +A+++ G+SL++ + ++ ++ + + + F + I
Sbjct: 2113 AFFEVKQTTEPNFPEILL-IAINKYGVSLIDPKTKDILTTHPFTKISNWSSGNTYFHITI 2171
Query: 1412 NN 1413
N
Sbjct: 2172 GN 2173
>gi|122937512 myosin VIIB [Homo sapiens]
Length = 2116
Score = 74.3 bits (181), Expect = 8e-13
Identities = 79/417 (18%), Positives = 179/417 (42%), Gaps = 39/417 (9%)
Query: 1000 ISLAQSALQICLTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPF 1059
+ L + L HP LQ+E+ CQ++KQ N+ +GWQLL LC GLF P
Sbjct: 1690 LELTDQIFTLALQHPALQDEVYCQILKQLTHN--SNRHSEERGWQLLWLCTGLFPPSKGL 1747
Query: 1060 LWLLRLHLKRNADSRTEFGK-YAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHS 1118
L H ++ D+R GK A C R +++ + G R+ P ++E+ + +
Sbjct: 1748 L----PHAQKFIDTRR--GKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAA-----EQNV 1796
Query: 1119 LPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEH 1178
++F N +++ A+T V + +++ T ++ + G +LF S + +
Sbjct: 1797 SRICHKIYFPNDTSEMLEVVANTRVRDVCDSI--ATRLQLASWEGCSLFI-KISDKVISQ 1853
Query: 1179 CLQGNIKICDI--ISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLL 1236
+G+ + +S W + +K Q+ G T ++ + +L+ ++ + + + +L
Sbjct: 1854 -KEGDFFFDSLREVSDWVKKNKPQKEG-APVTLPYQVYFMRKLWLNISPGKDVNADTILH 1911
Query: 1237 MYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVI 1296
+Q + + G +++ A+ +A L+ + + N ++ +++
Sbjct: 1912 YHQELPKYLRGFHKCSREDAIHLAGLIYKAQF--------------NNDRSQLASVPKIL 1957
Query: 1297 EKFYPKRYRDGCSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLA 1356
+ P+ S E+ + + + + + + + +L +WP FG+ F
Sbjct: 1958 RELVPENLTRLMSSEEWK---KSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEV 2014
Query: 1357 KPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINN 1413
K + S L +A++ G+ L+ + L+ +Y + + ++ F + + +
Sbjct: 2015 KQTSEPSYPDVIL-IAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGS 2070
Score = 52.0 bits (123), Expect = 4e-06
Identities = 84/387 (21%), Positives = 148/387 (38%), Gaps = 48/387 (12%)
Query: 1011 LTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRN 1070
+ P L++EI CQ+ KQ + +GW LL+LC+G F P F+ L + +
Sbjct: 1101 ILRPSLRDEIYCQICKQLSENFKTSSLA--RGWILLSLCLGCFPPSERFMKYLLNFIGQG 1158
Query: 1071 ADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNG 1130
Y +C + RT NG R P+ +E+ + +++ H I V G
Sbjct: 1159 P------ATYGPFCAERLRRTYANGVRAEPPTWLELQA--VKSKKH----IPIQVILATG 1206
Query: 1131 IYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFAL-------FTDDPSGRDLEHCLQGN 1183
V D+++T E + G+ GF+L F SGRD
Sbjct: 1207 ESLTVPVDSASTSREMCMHIAHKQGLSD--HLGFSLQVAVYDKFWSLGSGRD-------- 1256
Query: 1184 IKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQ 1243
+ D I++ EQ ++E+ G+ + R+ ++ + E L+ Q
Sbjct: 1257 -HMMDAIARCEQMAQER--GESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRG 1313
Query: 1244 IINGLFPLNKDLAL-EMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPK 1302
+ +G + K+ L E+ A V++G S + C ++ + +
Sbjct: 1314 VWSGEYSFEKEEELVELLARHCYVQLGASAE--SKAVQELLPSCIPHKLYRTKPPDRWAS 1371
Query: 1303 RYRDGCSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPS 1362
C++ Q +A+R D R+ +WP ++LF ++
Sbjct: 1372 LVTAACAKAPYTQ----KQVTPLAVR-EQVVDAARL------QWPLLFSRLFEVITLSGP 1420
Query: 1363 SLGSTFLWLAVHEDGLSLLEYNSMRLI 1389
L T L LAV+ GL L+ L+
Sbjct: 1421 RLPKTQLILAVNWKGLCFLDQQEKMLL 1447
>gi|40255047 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 3 [Homo sapiens]
Length = 793
Score = 67.8 bits (164), Expect = 8e-11
Identities = 106/451 (23%), Positives = 162/451 (35%), Gaps = 68/451 (15%)
Query: 949 RHPTLCHSKEGIISPLTTLPSEA---------LQTEAIKLFKTCQLFINAAVDSPAIDYH 999
R+P L H+ + +PL LP L+ EA++LF Q A P
Sbjct: 231 RNPILRHTSGALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGP----- 285
Query: 1000 ISLAQSALQICLTHPELQNEICCQLIKQTRRRQ-----PQNQ-PGPLQGWQLLALCVGLF 1053
L Q LQ C P L++E+ QL KQT P Q P L+ WQLL F
Sbjct: 286 --LMQGVLQTCRDLPALRDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTF 343
Query: 1054 LPHHPFLWLLRLHLKRNADS--RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLL 1111
P L HL+R + +E +YA + ++ + RT+ RE PS EI +
Sbjct: 344 RPGGAVRGHLLGHLERTEQALPDSELAEYARFIRKALGRTR---GRELVPSLAEISALSQ 400
Query: 1112 RNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDP 1171
R VH V D+ TT E L G+ + +++ FAL+
Sbjct: 401 RQ------ELLCTVHCPGAGACAVAIDSHTTAGEVARELVGRLGLAR-SRNAFALYEQRG 453
Query: 1172 SGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDR 1231
+ E L G + D+++++E + E+ + RL + +
Sbjct: 454 A---QERALAGGTLVADVLTRFENLAAEEAGLEDSPDSGWRLCLRLHGPLHPEGLSPDGH 510
Query: 1232 EKLLLMYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDF-------------------- 1271
E L Q + ++ G P D +AAL Q DF
Sbjct: 511 ELPFLFEQAHALLLRGRPPPPDDTLRALAALRLQSLHRDFSPRVPLPRLDRLLPPPAPPR 570
Query: 1272 -ERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQR----------L 1320
+ P TP + + K +R R G + + + +
Sbjct: 571 EDPPRPTPRPPPSAALLAGALWSPGLAKRRAERARRGGAGRTAGSIAREGGGGAGTAAAV 630
Query: 1321 STRWMALRGHSAADCVRIYLTVARKWPFFGA 1351
W LRG A+ + YL +A + P FGA
Sbjct: 631 LGGWKRLRGMGRAEAMAAYLALAAQCPGFGA 661
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 61.6 bits (148), Expect = 5e-09
Identities = 59/259 (22%), Positives = 126/259 (48%), Gaps = 34/259 (13%)
Query: 8 EGPVDWKERCVALESQLMKFRVQASKIRE---LLAEKMQQLERQVIDAERQAEKAFQQVQ 64
E D KE+ + Q+ + + + S +R+ LL K+ +LE++ ++ + + +Q
Sbjct: 1243 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQ 1302
Query: 65 VMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIE 124
++++L N + E+ + C+DL K+ +I+++ + LEEQ+Q ++++ +++E
Sbjct: 1303 QLKEQLN--NQKVEEAIQQYERACKDLNV----KEKIIEDMRMTLEEQEQTQVEQDQVLE 1356
Query: 125 EK-------AAKIKEWVTVKLNELELE-NQNLRLINQNQTE---EIRTMQSKLQEVQGKK 173
K A ++++W K N+LE + NQ ++N T+ ++ +Q +LQE + K
Sbjct: 1357 AKLEEVERLATELEKW-KEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKY 1415
Query: 174 SSTVSTLKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKIS-SKEPEFTEGKDMEEM- 231
++ R L L + ++++EM K + +E F + +ME +
Sbjct: 1416 NA----------DRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILT 1465
Query: 232 -EIPEKSVDNQVLENNRGQ 249
++ EK D Q R Q
Sbjct: 1466 AQLTEKDSDLQKWREERDQ 1484
Score = 42.4 bits (98), Expect = 0.003
Identities = 82/414 (19%), Positives = 172/414 (41%), Gaps = 53/414 (12%)
Query: 20 LESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVME---DKLKAANIQ 76
+ Q+ ++R+Q ++ + + + + + K Q++ +E +KL+A
Sbjct: 995 VSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKG 1054
Query: 77 TSESETRLYNK-CQDLESLIQEKDDVIQNLELQLEEQK-QIRIQEAKIIEEKAA--KIKE 132
+ RL K ++ + L++EK+ +IQ L+ +L+E+ + +Q ++E K A ++ +
Sbjct: 1055 YKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQ 1114
Query: 133 WVT---VKLNELE--LENQNLRLINQNQTEE---------------IRTMQSKLQE-VQG 171
VT K+ ELE LE Q + + + E+ ++ Q LQ+ V+
Sbjct: 1115 GVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKN 1174
Query: 172 KKSSTVSTLKLSE--GQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDME 229
K V LKL E Q ++L L + + + +E K+ + +
Sbjct: 1175 TKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNL 1234
Query: 230 EMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDG---GISQNSGAPVSDW 286
+ ++ K D L+ L +Q +K + + I N +
Sbjct: 1235 KADLQRKEEDYADLKEK-----LTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQ 1289
Query: 287 SSDEEDGSKGRSKSRCTSTLSSHTSEEGVQ-----CSRMG------SEMYLTASD-DSSS 334
S E D K R+ + L++ EE +Q C + +M +T + + +
Sbjct: 1290 CSQELD-MKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQ 1348
Query: 335 IFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNK 388
+ +++ K E ++L + + +WK + L N++ S KE ++++D L K
Sbjct: 1349 VEQDQVLEAKLEEVERLAT--ELEKWKEKCNDLETKNNQRSNKEHENNTDVLGK 1400
Score = 37.7 bits (86), Expect = 0.084
Identities = 40/190 (21%), Positives = 88/190 (46%), Gaps = 18/190 (9%)
Query: 8 EGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVME 67
+G +K + LE+ L +V+ S +L + +++ E ++ ER ++ + +Q
Sbjct: 1114 QGVTCYKAKIKELETILETQKVECSHSAKLEQDILEK-ESIILKLERNLKEFQEHLQDSV 1172
Query: 68 DKLKAANIQT---SESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQ------IRIQ 118
K N++ E T+L N QD++ L+Q K++ + + E+ K+ R Q
Sbjct: 1173 KNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQ 1232
Query: 119 EAKI----IEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKS 174
K EE A +KE +T +++ + + ++ +E + ++ K+ E++ KK+
Sbjct: 1233 NLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMR----DEDKLLRIKINELEKKKN 1288
Query: 175 STVSTLKLSE 184
L + +
Sbjct: 1289 QCSQELDMKQ 1298
Score = 35.0 bits (79), Expect = 0.54
Identities = 31/158 (19%), Positives = 67/158 (42%), Gaps = 2/158 (1%)
Query: 6 EPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQV 65
E E D + L+ +L + + + R+ E+ L Q +AE K ++
Sbjct: 1390 EHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAE 1449
Query: 66 MEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEE 125
++ + +L K DL+ +E+D ++ LE+QL+ +Q+ IE+
Sbjct: 1450 DRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQ 1509
Query: 126 KAAKIKEWVTVKLNELELENQNLRLINQN--QTEEIRT 161
I E ++ ++++ + + + + QTE + T
Sbjct: 1510 LKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLST 1547
Score = 34.7 bits (78), Expect = 0.71
Identities = 60/230 (26%), Positives = 93/230 (40%), Gaps = 35/230 (15%)
Query: 35 RELLAEKMQQLE-----RQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRL----- 84
++L+ EK ++L R+ + E A ++ E L+ I +E RL
Sbjct: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKD 644
Query: 85 -YNKCQDLESLIQ-------EKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTV 136
KC E + E ++ LEL+ QI+ + AK E K KE +
Sbjct: 645 LVGKCDTREEAAKDICATKVETEEATACLELKFN---QIKAELAKTKGE-LIKTKEELKK 700
Query: 137 KLNEL-----ELENQNLRLINQNQ--TEEIRTMQSK---LQEVQGKKSSTVSTLKLSEGQ 186
+ NE ELE N ++I QNQ E I + K + E Q KS +T K ++
Sbjct: 701 RENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKA 760
Query: 187 RLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEK 236
SSL L + V + SKI S+ E ++++ E P K
Sbjct: 761 DTSSLIINNKL--ICNETVEVPKDSKSKICSERKRVNE-NELQQDEPPAK 807
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 58.9 bits (141), Expect = 4e-08
Identities = 89/412 (21%), Positives = 163/412 (39%), Gaps = 56/412 (13%)
Query: 20 LESQLMKFRVQASKIREL--LAEKMQQLERQVIDAERQAEKAFQQVQVM---EDKLKAAN 74
L Q + R Q ++RE L E+ +Q++ Q Q EK +Q + M E++L
Sbjct: 323 LREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
Query: 75 IQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWV 134
Q E E K +D E + E+D+ ++ E ++ EQ+++ Q K+ EEK + +E
Sbjct: 383 KQMREQE----QKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKK 438
Query: 135 TVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFG 194
T E E + +R + EE TM+ + +++Q K+ + + E Q
Sbjct: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ-KQEENMWEQEEKEWQ-------- 489
Query: 195 CFLSRARSPPQVVKSEEMSKISSKEPEFTEG----KDMEEMEIPEKSV---------DNQ 241
+ R P Q K E K+ +E + E +D EEM EK + ++Q
Sbjct: 490 ----QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 242 VLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSR 301
+ E R Q E+ + +T Q + EE+ + R K
Sbjct: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQ-------EQEKKTWDQEEKMREEERMREREKKM 598
Query: 302 CTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPE-----HKKLYSWQQ 356
EE +Q E + ++E+E ++ E +K++ Q+
Sbjct: 599 REEEEMMREQEEKMQ------EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE-QE 651
Query: 357 EAQWKALNSPLGKGN--SELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANT 406
E W+ P K +EQ+ ++ K ++ ++++ + E T
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
Score = 39.7 bits (91), Expect = 0.022
Identities = 36/150 (24%), Positives = 77/150 (51%), Gaps = 14/150 (9%)
Query: 26 KFRVQASKI--RELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETR 83
K + Q KI +E + +K Q+ E++ D E+ E+ + ++ E K++ E E
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE--ESMREREKKMREEEEMMREQE-- 733
Query: 84 LYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELE- 142
K Q+ E +QE+++ + E ++ EQ++ ++ ++ E+K K W K+ E E
Sbjct: 734 --EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE---KLWEHEKMQEQEK 788
Query: 143 LENQNLRLINQNQTEEIRTMQSKLQEVQGK 172
+ Q ++ ++Q E++R + K++ + K
Sbjct: 789 IWEQEEKM--RDQEEKMRGQEEKMRGQEEK 816
>gi|154146216 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 2 [Homo
sapiens]
Length = 425
Score = 58.5 bits (140), Expect = 5e-08
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 10/109 (9%)
Query: 703 PLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIEL-----SASCSI 757
PL KSGY +K KSWKRR+F L + Y+K D R+P I L + C +
Sbjct: 198 PLIKSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQD--REPLRTIFLKDVLKTHECLV 255
Query: 758 LRGD---NKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANP 803
GD ++ T T+Y+ ADSP + WIK + ++ +P
Sbjct: 256 KSGDLLMRDNLFEIITSSRTFYVQADSPEDMHSWIKEIGAAVQALKCHP 304
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 58.2 bits (139), Expect = 6e-08
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 12/161 (7%)
Query: 12 DWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLK 71
+W+E+ ++ Q K R Q KIRE EKM++ E + + E + + + + E+K++
Sbjct: 311 EWEEK---IQEQEEKIREQEEKIREQ-EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 72 AANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIK 131
E E ++ + E ++ EK++ I+ LE ++ EQ++IR QE K EE+ KI+
Sbjct: 367 RQEEMMWEKEEKMRRQ----EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE--KIR 420
Query: 132 EWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGK 172
E + E ++ Q ++ + Q E+IR + K+ + K
Sbjct: 421 EQEKRQEQEAKMWRQEEKI--REQEEKIREQEKKMWRQEEK 459
Score = 48.5 bits (114), Expect = 5e-05
Identities = 35/147 (23%), Positives = 77/147 (52%), Gaps = 7/147 (4%)
Query: 26 KFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLY 85
K R Q K R+ EKM + E ++ + E + ++ ++++ E+K++ T E E ++
Sbjct: 592 KIREQEEK-RQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 86 NK----CQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNEL 141
+ C+ E + ++++ + + E E++K+IR QE KI E++ ++ + E
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 710
Query: 142 ELENQNLRLINQNQTEEIRTMQSKLQE 168
++ Q ++ Q Q E++R + K+ E
Sbjct: 711 KMCEQEEKM--QEQEEKMRRQEEKMWE 735
Score = 48.1 bits (113), Expect = 6e-05
Identities = 54/266 (20%), Positives = 118/266 (44%), Gaps = 20/266 (7%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
A+L E V+ ++ + L + +K +++ +K+ LL ++ Q E + E Q+ A
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKL--LLPQQQLQAEADHLGKELQSVSAKL 281
Query: 62 QVQVMEDKL-KAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA 120
Q QV E++L N Q E R K Q+ E IQE+++ I+ E ++ EQ++ ++
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 121 KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL 180
+++ EK K++ + E+ E + + E + +E+ +K + L
Sbjct: 342 EMMWEKEEKMR-----RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 396
Query: 181 --KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSV 238
K+ E +++ R + ++ +E +E E + E++ E+ +
Sbjct: 397 EEKMHEQEKIRE------QEEKRQEEEKIREQE----KRQEQEAKMWRQEEKIREQEEKI 446
Query: 239 DNQVLENNRGQRTLHQTPCGSEQNRK 264
Q + R + +H+ E+ ++
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKR 472
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/150 (26%), Positives = 77/150 (51%), Gaps = 22/150 (14%)
Query: 26 KFRVQASKIRELLAEKMQQLERQVIDAE---RQAEKAFQQVQVMEDKLKAANIQTSESET 82
K R Q KIRE EKM + E ++ + E R+ EK +Q ++ E++ + E E
Sbjct: 518 KIREQEEKIREQ-EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKR------QEQED 570
Query: 83 RLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELE 142
+++ + E I+E+++ + E ++ EQ++ R ++ EEK K +E + + +++
Sbjct: 571 KMWRQ----EEKIREQEEKVWRQEEKIREQEEKRQEQ----EEKMWKQEEKIREQEEKIQ 622
Query: 143 LENQNLRLINQNQTEEIRTMQSKLQEVQGK 172
+ + +R Q E+IR + QE + K
Sbjct: 623 EQEEKIR----EQEEKIREQEEMTQEQEEK 648
Score = 40.8 bits (94), Expect = 0.010
Identities = 54/257 (21%), Positives = 106/257 (41%), Gaps = 33/257 (12%)
Query: 14 KERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAA 73
KE+ L+ +L + S+I+ + E ++LER + +Q +A E + +A
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 74 NIQTSESETRLYNKC-QDLESLIQEKDDVIQNLELQLEEQKQ-IRIQEAKI--IEEKAAK 129
+Q E L+N+ Q E + +++ IQ E +++EQ++ IR QE KI EEK +
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 130 IKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLS 189
+E + K ++ + + + + E++R + + E + K
Sbjct: 340 QEEMMWEKEEKMRRQEEMM----WEKEEKMRRQEEMMWEKEEK----------------- 378
Query: 190 SLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQ 249
R + K E++ ++ K E + ++ EE E+ + Q +
Sbjct: 379 --------MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430
Query: 250 RTLHQTPCGSEQNRKTR 266
+ Q EQ K R
Sbjct: 431 KMWRQEEKIREQEEKIR 447
Score = 38.5 bits (88), Expect = 0.049
Identities = 38/152 (25%), Positives = 74/152 (48%), Gaps = 23/152 (15%)
Query: 33 KIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLY---NKCQ 89
KIREL EKM + E+ Q EK ++ ++ E + + E E +++ K +
Sbjct: 392 KIREL-EEKMHEQEK----IREQEEKRQEEEKIREQE------KRQEQEAKMWRQEEKIR 440
Query: 90 DLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEE----KAAKIKEWVTVKLNELELEN 145
+ E I+E++ + E ++ EQ++IR +E + +E + KI E + + ++
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 146 QNLRLINQ-----NQTEEIRTMQSKLQEVQGK 172
Q ++ Q Q E+IR + K++E + K
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Score = 38.5 bits (88), Expect = 0.049
Identities = 55/234 (23%), Positives = 104/234 (44%), Gaps = 28/234 (11%)
Query: 26 KFRVQASKIRELLAEKMQQLERQVIDAE--RQAEKAFQQVQVMEDKLKAANIQTSESETR 83
K R Q KIRE +KM + E ++ + E R+ EK +Q ++ + K I E R
Sbjct: 438 KIREQEEKIREQ-EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK---IHEQEEIWR 493
Query: 84 LYNKCQDLESLIQEKDDVIQNLELQLEEQKQ-IRIQEAKIIEEKAAKIKEWVTVKLNELE 142
K + E I+++++ + E ++ EQ++ IR QE K+ ++ KI+E + E +
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE-EKIREQEEMWREEEK 552
Query: 143 LENQNL---RLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCFLSR 199
+ Q Q Q +++ + K++E + K ++ E + R
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK------------R 600
Query: 200 ARSPPQVVKSEEMSKISSKEPEFTEGKDM---EEMEIPEKSVDNQVLENNRGQR 250
++ K EE KI +E + E ++ +E +I E+ Q E G++
Sbjct: 601 QEQEEKMWKQEE--KIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Score = 31.6 bits (70), Expect = 6.0
Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 20 LESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSE 79
+ Q K R Q KIRE E MQ+ E ++ + E + + +++Q E+K++ + E
Sbjct: 677 IREQEKKIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 735
Query: 80 SETRL 84
E RL
Sbjct: 736 QEVRL 740
>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
[Homo sapiens]
Length = 934
Score = 57.4 bits (137), Expect = 1e-07
Identities = 49/171 (28%), Positives = 80/171 (46%), Gaps = 19/171 (11%)
Query: 630 SRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPE---- 685
S SSS +S+ DSR S ++R S S+ S S + P+ E E
Sbjct: 21 SASSSTSSQRDSRQ-----SIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEG 75
Query: 686 QKLPKTCSSSSDNGKNEPLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIRK 744
K+ +T +P + G++LK +K W +R+FVL G L Y K+P D I+K
Sbjct: 76 LKIGQT-------NVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLD-IQK 127
Query: 745 PQGHIELSASCSILRGDNK-QTVQLTTEKHTYYLTADSPNILEEWIKVLQN 794
+ H + S++ K + + L TE+H Y+L S + + W+ L++
Sbjct: 128 GKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRH 178
>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
[Homo sapiens]
Length = 820
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 698 NGKNEPLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIR-KPQGHIELSASC 755
N EP + G+LLK +K W +R+F L G L Y KS +D+ R K G I++ S
Sbjct: 46 NYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSV 105
Query: 756 SILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQP 808
++ +K + L TE+H Y+L S + +EW+ L++ R+ N +++ P
Sbjct: 106 MSVKKSSK-CIDLDTEEHIYHLKVKSEEVFDEWVSKLRH-HRMYRQNEIAMFP 156
>gi|21735582 oxysterol-binding protein-like protein 3 isoform c
[Homo sapiens]
Length = 851
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 698 NGKNEPLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIR-KPQGHIELSASC 755
N EP + G+LLK +K W +R+F L G L Y KS +D+ R K G I++ S
Sbjct: 46 NYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSV 105
Query: 756 SILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQP 808
++ +K + L TE+H Y+L S + +EW+ L++ R+ N +++ P
Sbjct: 106 MSVKKSSK-CIDLDTEEHIYHLKVKSEEVFDEWVSKLRH-HRMYRQNEIAMFP 156
>gi|21735580 oxysterol-binding protein-like protein 3 isoform b
[Homo sapiens]
Length = 856
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 698 NGKNEPLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIR-KPQGHIELSASC 755
N EP + G+LLK +K W +R+F L G L Y KS +D+ R K G I++ S
Sbjct: 46 NYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSV 105
Query: 756 SILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQP 808
++ +K + L TE+H Y+L S + +EW+ L++ R+ N +++ P
Sbjct: 106 MSVKKSSK-CIDLDTEEHIYHLKVKSEEVFDEWVSKLRH-HRMYRQNEIAMFP 156
>gi|14149704 oxysterol-binding protein-like protein 3 isoform a
[Homo sapiens]
Length = 887
Score = 57.4 bits (137), Expect = 1e-07
Identities = 37/113 (32%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 698 NGKNEPLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIR-KPQGHIELSASC 755
N EP + G+LLK +K W +R+F L G L Y KS +D+ R K G I++ S
Sbjct: 46 NYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSV 105
Query: 756 SILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQP 808
++ +K + L TE+H Y+L S + +EW+ L++ R+ N +++ P
Sbjct: 106 MSVKKSSK-CIDLDTEEHIYHLKVKSEEVFDEWVSKLRH-HRMYRQNEIAMFP 156
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 57.4 bits (137), Expect = 1e-07
Identities = 50/192 (26%), Positives = 77/192 (40%), Gaps = 23/192 (11%)
Query: 643 SRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNE 702
+++G P + ++ SE +PP+ S + + S S N
Sbjct: 3 NKTGGKRPATTNSDIPNHNMVSE----VPPERPSVRATRTARKAVAFGKRSHSMKRNPNA 58
Query: 703 PLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSA--SCSILR 759
P+ K+G+L K S VK W +RWFVL L YYK + G I L + ++
Sbjct: 59 PVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKE--ESILGSIPLLSFRVAAVQP 116
Query: 760 GDNKQTVQLTTEKH----TYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMK 815
DN +H TY+ +A+SP E WI+ + RVQ P K
Sbjct: 117 SDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQI----------PPAQK 166
Query: 816 GLLTKVKHGYSK 827
+ V+H + K
Sbjct: 167 SVPQAVRHSHEK 178
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 57.0 bits (136), Expect = 1e-07
Identities = 34/107 (31%), Positives = 55/107 (51%), Gaps = 20/107 (18%)
Query: 706 KSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSAS------CS--- 756
K G+L K G VK+W RWFVLKG +L Y+K + KP G I L + C+
Sbjct: 22 KCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDET--KPLGTIFLPGNKVSEHPCNEEN 79
Query: 757 -------ILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVL 796
++ G ++ ++T +Y L A + N +E+W+K ++ V+
Sbjct: 80 PGKFLFEVVPGGDRD--RMTANHESYLLMASTQNDMEDWVKSIRRVI 124
Score = 31.2 bits (69), Expect = 7.8
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 830 WCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEE 862
W L G LYYF+ +++ PLG I L KV E
Sbjct: 40 WFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSE 72
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 56.6 bits (135), Expect = 2e-07
Identities = 71/397 (17%), Positives = 159/397 (40%), Gaps = 31/397 (7%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
AEL E V+ ++ + L + +K +++ KI ++++ E QV + E Q +
Sbjct: 14 AELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEG 73
Query: 62 QVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQK-QIRIQEA 120
QV+ E +++ Q E E ++ ++ E ++E++ ++ E Q+ EQ+ Q+R QE
Sbjct: 74 QVREQEGQVREQEGQVREQEGQV----REQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 121 KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL 180
++ E++ ++ V+ E ++ Q ++ + Q ++R + +++E +G+ +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 181 KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN 240
+ EGQ Q+ + EE ++ + E + E+ E K +
Sbjct: 188 REQEGQM------------GEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQ 235
Query: 241 QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS 300
+ + Q+ Q EQ RK EE K + ++
Sbjct: 236 MGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE----------EQMREQEEQMLKQKEQT 285
Query: 301 RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPE--HKKLYSWQQEA 358
+ Q +M + + +EE G + + +K W+Q+
Sbjct: 286 EQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKE 345
Query: 359 QWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRL 395
Q +G+ ++ K+E+ E + Q +++
Sbjct: 346 QMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Score = 47.0 bits (110), Expect = 1e-04
Identities = 48/231 (20%), Positives = 106/231 (45%), Gaps = 10/231 (4%)
Query: 3 ELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQ 62
++ E EG + +E + + + M+ + + +E E+M++ E Q+ + E Q +K +Q
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE---EQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 63 VQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKI 122
VQ E++++ Q E E ++ + E ++++K+ Q E E+++Q+R QE ++
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMR---EQEEQMLKQKEQTEQE-EQTGEQEEQMREQEEQM 305
Query: 123 IEEKAAKIKEWVTVKLNELELENQNLRLINQ-NQTEEIRTMQSKLQEVQGKKSSTVSTLK 181
E++ ++ ++ E ++ Q ++ Q Q E + K +E G++ + K
Sbjct: 306 REQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ--K 363
Query: 182 LSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEME 232
E R + R + ++ +E KE + + M E E
Sbjct: 364 QEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQE 414
Score = 38.5 bits (88), Expect = 0.049
Identities = 27/113 (23%), Positives = 61/113 (53%), Gaps = 7/113 (6%)
Query: 21 ESQLMKFRVQASKIRELLAEKMQQL---ERQVIDAERQAEKAFQQVQVMEDKLKAANIQT 77
E Q+ K Q + +E + E+ +Q+ E Q+ + E Q +K +QV+ E++++ Q
Sbjct: 323 EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Query: 78 SESETRLYNKCQDL----ESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEK 126
+ E ++ + + + E + ++K+ + + E E+++Q+R QE + E+K
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 34.3 bits (77), Expect = 0.93
Identities = 29/137 (21%), Positives = 70/137 (51%), Gaps = 6/137 (4%)
Query: 20 LESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSE 79
+ Q + R Q ++RE E+M++ E Q+ E Q + +Q+ ++++ Q E
Sbjct: 298 MREQEEQMREQEEQMREQ-EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGE 356
Query: 80 SETRLYNKCQDLESLIQEKDDVIQNLELQLEEQK-QIRIQEAKIIEEKAAKIKEWVTVKL 138
E ++ Q E ++++++ ++ E Q+ +Q+ Q+R QE ++ E+K ++ ++
Sbjct: 357 QEEQM----QKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 139 NELELENQNLRLINQNQ 155
E ++ Q ++ Q +
Sbjct: 413 QEEQMGEQKEQMRKQEE 429
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 56.6 bits (135), Expect = 2e-07
Identities = 100/504 (19%), Positives = 173/504 (34%), Gaps = 17/504 (3%)
Query: 209 SEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTS 268
S+ + S + + D S D+ N+ + GS+ + R+
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860
Query: 269 FATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTA 328
+ S +S + S SSD D ++ + S + + +S S+ + S +
Sbjct: 861 SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS 920
Query: 329 SDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKA--LNSPLGKGNSELSKKEQDSSSDEL 386
SD S S + + S ++ + NS +S+ S SSD
Sbjct: 921 SDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSS 980
Query: 387 NKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNV 446
N S D S SS +++ + + +S S + SS N
Sbjct: 981 NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS----------NS 1030
Query: 447 FSISVALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDG-DSTEVLENMDT 505
S + S SSD +N + S D D DS+E ++ D+
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090
Query: 506 SCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMS 565
S S DS DS +S D + + S + S +S + + S
Sbjct: 1091 SNSSD--SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148
Query: 566 EAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQIS-SSPFLDDSSGS 624
E+ + + +S ++ S +S S N + ++ ++ S SS D S S
Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1208
Query: 625 EEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQP 684
+ DSS SS + SDS S S ++ SD + D+ S T S
Sbjct: 1209 DSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDS-SDSTSDSND 1267
Query: 685 EQKLPKTCSSSSDNGKNEPLEKSG 708
E + ++NG + + G
Sbjct: 1268 ESDSQSKSGNGNNNGSDSDSDSEG 1291
Score = 56.2 bits (134), Expect = 2e-07
Identities = 97/506 (19%), Positives = 177/506 (34%), Gaps = 18/506 (3%)
Query: 198 SRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPC 257
S + S S+ S + + D + S D+ +++ + ++
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD- 632
Query: 258 GSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQC 317
S+ + K+ +S + S NS + S SS+ D S S +S+ S S +
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692
Query: 318 SRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKK 377
S + + S DSS ++ S + NS +S+ S
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752
Query: 378 EQDS-SSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHL 436
S SSD N S D S SS +N+ + +S S + SS
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812
Query: 437 PPPK----LRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLV 492
+ + S + + S SSD G++ ++ + ++
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872
Query: 493 DGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWES 552
+S++ ++ D++ + S DS DS NS D + DS+ S S +S
Sbjct: 873 SSNSSDSSDSSDSN--ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN-------SSDS 923
Query: 553 RIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQI 612
+ + S++ N + +S ++ S +S S N + + +
Sbjct: 924 SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS---SNSSDSSDSNSSDSSDSS 980
Query: 613 SSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPP 672
+SS D S S+ DSS SS+ + SDS S + S+ + SD +
Sbjct: 981 NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSS 1040
Query: 673 DAYSTDTEYSQPEQKLPKTCSSSSDN 698
D+ + + S SSD+
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDS 1066
Score = 55.8 bits (133), Expect = 3e-07
Identities = 94/487 (19%), Positives = 166/487 (34%), Gaps = 23/487 (4%)
Query: 213 SKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATD 272
S SS+ + ++ D + + + S N ++ + S+ + + +S ++D
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 273 GGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDS 332
S +S + S SSD D S S + + S S + S + S DS
Sbjct: 755 S--SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812
Query: 333 SSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQS 392
S + ++ + S +S +S+ S S SD N+ S
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSS----------DSSNSSDSSDSSDSSDGSDSDSSNRSDSS 862
Query: 393 QRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNVFSISVA 452
D S SS +N+ + + N S S+ N S +
Sbjct: 863 NSSDSSDSSDSSNS-----SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 453 LAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDSTEVLENMDTSCDDGLF 512
S+ SSD N N+ ++ DS+ ++ ++S
Sbjct: 918 SNSSDSSESSNSSD-----NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972
Query: 513 SYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMES 572
S DS DS NS D + + S + S +S + + S++ N
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 573 VNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQIS-SSPFLDDSSGSEEEDSSR 631
+ +S ++ S +S S N + ++ ++ S SS D S S+ DSS
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092
Query: 632 SSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKT 691
SS + SDS S S+ + SD + D+ + +
Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSD 1152
Query: 692 CSSSSDN 698
S SSD+
Sbjct: 1153 SSDSSDS 1159
Score = 51.6 bits (122), Expect = 6e-06
Identities = 100/495 (20%), Positives = 180/495 (36%), Gaps = 22/495 (4%)
Query: 213 SKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATD 272
S SS + + D + S D+ ++ + S+ + + +
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 273 GGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDS 332
S +S + S SSD DGS S +R S+ SS +S+ + S +++ S
Sbjct: 830 SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889
Query: 333 SSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQS 392
+S ++ S ++ + +S ++ E +SSD N S
Sbjct: 890 NSSDSSDSSN----------SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSS 939
Query: 393 QRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNVFSISVA 452
D SS SS+++ S + +S + SS+ + S S +
Sbjct: 940 NSSD-SSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS-SDS 997
Query: 453 LAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDG-DSTEVLENMDTSCDDGL 511
+ S SSD +N + S D D DS++ ++ D+S D
Sbjct: 998 SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS--DSS 1055
Query: 512 FSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNME 571
S DS DS +S D + + S + S +S + + S++ +
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Query: 572 SVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDDSSGSEEEDSSR 631
+ +S ++ S +S S N + ++ ++ S S D S S+ DSS
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSS--DSSDSSDSSDSSD 1173
Query: 632 SSSRTSESDS-----RSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQ 686
SS ++ SDS S S S + S SS +S+S + S ++ S +
Sbjct: 1174 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNE 1233
Query: 687 KLPKTCSSSSDNGKN 701
+ SS S + N
Sbjct: 1234 SSDSSDSSDSSDSSN 1248
Score = 47.0 bits (110), Expect = 1e-04
Identities = 114/574 (19%), Positives = 202/574 (35%), Gaps = 59/574 (10%)
Query: 135 TVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFG 194
T KLN E + R+ +++T + Q K E++G S + K
Sbjct: 344 TQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITK------------- 390
Query: 195 CFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQ 254
+V K E K + GK + + +++ ++ G + H
Sbjct: 391 ----------EVGKGNE-GKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHS 439
Query: 255 TPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEG 314
GS+ N S+ D Q SD S+ +D + + + +S+ S+E
Sbjct: 440 NT-GSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDES 498
Query: 315 VQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSEL 374
GS+ DDS S T + + + K S GKG S+
Sbjct: 499 KDNGN-GSDSKGAEDDDSDS-----TSDTNNSDSNGNGNNGNDDNDK---SDSGKGKSDS 549
Query: 375 SKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSS 434
S + SSD N S D SS S +++ S +S + SS
Sbjct: 550 SDSD---SSDSSNSSDSSDSSDSDSSDSNSSSDSD-------SSDSDSSDSSDSDSSDSS 599
Query: 435 HLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDG 494
N S + S SSD ++++ ++ D D
Sbjct: 600 ----------NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDS----SDSDSKSDSSDS 645
Query: 495 DSTEVLENMDTS-CDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESR 553
+S++ +N D+S + S DS DS +S D + + S + + S +S
Sbjct: 646 NSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS 705
Query: 554 IYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQIS 613
+ + S + + S + +S ++ S +S S + + ++ ++ S
Sbjct: 706 DSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSS 765
Query: 614 SSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPD 673
S DSS S + +S S+ +S S S S S + S SS +S+SD + D
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825
Query: 674 AYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKS 707
+ ++ S SSD ++ +S
Sbjct: 826 SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRS 859
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 56.6 bits (135), Expect = 2e-07
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 703 PLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSAS-------- 754
P+ K+G+L K +K+W++RWFVL+G +L YYK ++ KPQG I L +
Sbjct: 37 PVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEI--KPQGFISLQGTQVTELPPG 94
Query: 755 --------CSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVL 796
I G + ++ L A S +E+W++ ++ V+
Sbjct: 95 PEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 56.2 bits (134), Expect = 2e-07
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 706 KSGYLLKMSGKVKSWKRRWFVLKGGELLYYKS-----PSDVIRKPQGH-IELSASCSILR 759
K+GY +K +K+WKRR+F L + Y+KS P VI + H ++ I+
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMM 253
Query: 760 GDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKP 812
DN ++ T T+Y+ ADSP + WIK + + Q S E P
Sbjct: 254 RDN--LFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPP 304
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 56.2 bits (134), Expect = 2e-07
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 706 KSGYLLKMSGKVKSWKRRWFVLKGGELLYYKS-----PSDVIRKPQGH-IELSASCSILR 759
K+GY +K +K+WKRR+F L + Y+KS P VI + H ++ I+
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMM 253
Query: 760 GDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKP 812
DN ++ T T+Y+ ADSP + WIK + + Q S E P
Sbjct: 254 RDN--LFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPP 304
>gi|169208517 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 602
Score = 55.5 bits (132), Expect = 4e-07
Identities = 90/427 (21%), Positives = 164/427 (38%), Gaps = 73/427 (17%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
+ L P+ P +ER V L+S+ ++ + I+ L +K +Q+E Q+ + ++ K +
Sbjct: 69 SSLHAPQSPC--QERAVVLDSRSVEISQLKNTIKSLKQQK-KQVEHQLEEEKKANNKKQK 125
Query: 62 QVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAK 121
+V+E +L+ NIQ E T LY+ + L ++ D+ L+ L+ + ++ +
Sbjct: 126 AKRVLEVQLQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGELESVLSD 185
Query: 122 IIEEKAAKIK----------EW-----------VTVKLNELELENQNLRLINQNQTEEIR 160
++ + K EW + V+L +L+ Q ++L +E ++
Sbjct: 186 VMATQKKKANQLSSPSKAGTEWKLEQSMREEALLKVQLTQLKESFQQVQLERDEYSEHLK 245
Query: 161 TMQSKLQEVQGKKSSTVSTLKLSEGQ----------RLSSLTFGCFLSRARSPPQVVKSE 210
+++ Q+ K S + TLK + Q LS L PP V
Sbjct: 246 GERARWQQRMRKMSQEICTLKKEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEV 305
Query: 211 EMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFA 270
E+ + KE E G E++ K+ L N R + + + E+ RK
Sbjct: 306 ELQHL-RKELERVAG----ELQAQVKNNQRISLLNQRQEERIREQ---EERLRKQEERIQ 357
Query: 271 TDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASD 330
Q P S + EE ++ +S T L E +
Sbjct: 358 EQHKSLQQLAKPQSVF---EEPNNENKS----TLQLEQQVKE---------------LQE 395
Query: 331 DSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKF 390
+ E ET K PE A+ A P G+ +S + E+ + EL KK
Sbjct: 396 KLGEVKESETSAQKEPE---------AARGPAAPGPGGESSSFMDHLEEKADLSELVKKQ 446
Query: 391 QSQRLDY 397
+ + + Y
Sbjct: 447 ELRFIQY 453
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 55.1 bits (131), Expect = 5e-07
Identities = 36/113 (31%), Positives = 58/113 (51%), Gaps = 26/113 (23%)
Query: 705 EKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIEL------------S 752
++ G+LLK+ G+VK+WKRRWF+L L Y++ +D ++P+G I L
Sbjct: 262 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVEDSKK 319
Query: 753 ASC-SILRGDNKQTV----------QLTTEKHTYY-LTADSPNILEEWIKVLQ 793
+C + DNK V ++ HT Y ++A +P EEWIK ++
Sbjct: 320 PNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIK 372
Score = 32.0 bits (71), Expect = 4.6
Identities = 17/40 (42%), Positives = 19/40 (47%)
Query: 827 KRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRS 866
KR W L LYYF DK P G I L + EV+ S
Sbjct: 278 KRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS 317
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 54.7 bits (130), Expect = 7e-07
Identities = 53/225 (23%), Positives = 107/225 (47%), Gaps = 17/225 (7%)
Query: 20 LESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSE 79
L+S K + Q + EL QQ E ++ E + ++ +++Q E+K++ +
Sbjct: 262 LQSVSAKLQAQVEE-NELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRR 320
Query: 80 SETRLYNKCQDL---ESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTV 136
E ++ K + + E ++ EK++ I+ LE ++ EQ++IR QE K EE+ KI+E
Sbjct: 321 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE--KIREQEKR 378
Query: 137 KLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCF 196
+ E ++ Q ++ + Q E+IR + +QE + K + E +
Sbjct: 379 QEQEAKMWRQEEKI--REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQ------ 430
Query: 197 LSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQ 241
+ R + ++ +E KI +E + E ++M M+ E+ + Q
Sbjct: 431 EEKMRRQEEKIREQE-KKIREQEEKIREQEEM--MQEQEEKMGEQ 472
Score = 48.1 bits (113), Expect = 6e-05
Identities = 70/397 (17%), Positives = 154/397 (38%), Gaps = 52/397 (13%)
Query: 14 KERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAA 73
KE+ L+ +L + S+I+ + E ++LER + +Q +A E + +A
Sbjct: 208 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 267
Query: 74 NIQTSESETRLYNKCQD--------LESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEE 125
+Q E L+N+ E IQE+++ IQ E ++ EQ++ ++ +++ E
Sbjct: 268 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 126 KAAKIKEWVTV------KLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVST 179
K K++ + K+ ELE + I + EE R + K++E + ++
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ--EEKRQEEEKIREQEKRQEQEAKM 385
Query: 180 LKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVD 239
+ E R + R ++++ +E +E + + ++M+E E + +
Sbjct: 386 WRQEEKIREQE-------EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE 438
Query: 240 NQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSK 299
++ E + R EQ K R + ++E+ +
Sbjct: 439 EKIREQEKKIR---------EQEEKIREQ---------------EEMMQEQEEKMGEQEG 474
Query: 300 SRCTSTLSSHTSEEGVQCSRMG-SEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEA 358
C EE ++ E + I E+E ++ E K W+QE
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM-MQEQEEK---MWEQEE 530
Query: 359 QWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRL 395
+ + + ++ ++E+ E+ + Q +++
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 39.7 bits (91), Expect = 0.022
Identities = 45/240 (18%), Positives = 100/240 (41%), Gaps = 13/240 (5%)
Query: 39 AEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEK 98
A +++Q V +++A++ +++ D L + + ++ L K L+ +Q
Sbjct: 162 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 221
Query: 99 DDVIQNLELQLEEQKQIRIQEAKII---------EEKAAKIKEWVTVKLNELELENQNLR 149
+ ++L ++E K+ +++ AK++ + K + V+ KL EN+
Sbjct: 222 ESEKSEIQLNVKELKR-KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 280
Query: 150 LINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEG--QRLSSLTFGCFLSRARSPPQV- 206
+NQ Q E++ + K+QE + K ++ E +R + + R +
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340
Query: 207 VKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTR 266
K E++ ++ K E + ++ EE E+ + Q + + Q EQ K R
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400
Score = 36.2 bits (82), Expect = 0.24
Identities = 25/115 (21%), Positives = 59/115 (51%), Gaps = 5/115 (4%)
Query: 14 KERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAA 73
+E+ ++ Q K Q K+ E A KMQ+ E ++ E + + ++++ E+K++
Sbjct: 456 REQEEMMQEQEEKMGEQEGKMCEQEA-KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Query: 74 NIQTSESETRLYNK----CQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIE 124
E E +++ + C+ E + ++++ + + E E++ ++R QE K+ E
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 32.7 bits (73), Expect = 2.7
Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
A++ E E + +E + Q K R Q KIRE E MQ+ E ++ + E + + +
Sbjct: 481 AKMQEQEEKMRRQEE--KIREQEKKIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEE 537
Query: 62 QVQVMEDKLKAANIQTSESETRL 84
++Q E+K++ + E E RL
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRL 560
>gi|239745114 PREDICTED: Golgin subfamily A member 8-like protein 3
[Homo sapiens]
Length = 580
Score = 54.3 bits (129), Expect = 9e-07
Identities = 68/316 (21%), Positives = 128/316 (40%), Gaps = 29/316 (9%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
A L + E P +ER V L+S+ ++ + I+ L +K +Q+E Q+ + ++ K +
Sbjct: 70 ATLKDLESPC--QERAVVLDSRSVEISQLKNTIKSLKQQK-KQVEHQLEEEKKANNKKQK 126
Query: 62 QVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAK 121
+V+E +++ NIQ E T LY+ + L ++ D+ L+ L+ + +
Sbjct: 127 AKRVLEVQIQTLNIQKEELNTDLYHMKRSLRYFEEKSKDLAVRLQHSLQRKGE------- 179
Query: 122 IIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLK 181
+E + + K N+ + Q ++L +E ++ +++ Q+ K S + TLK
Sbjct: 180 -LESVLSNVMATQKKKANQFKESFQQVQLERDEYSEHLKGERARWQQRMRKMSQEICTLK 238
Query: 182 LSEGQ----------RLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEM 231
+ Q LS L PP V E+ + KE E G E+
Sbjct: 239 KEKQQDMRRVEKLERSLSKLKNQMAEPLPPEPPAVPSEVELQHL-RKELERVAG----EL 293
Query: 232 EIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEE 291
+ K+ L N R + + + E+ RK Q P S + E
Sbjct: 294 QAQVKNNQRISLLNQRQEERIREQ---EERLRKQEERIQEQHKSLQQLAKPQSVFKEPEH 350
Query: 292 DGSKGRSKSRCTSTLS 307
+ + + T+ LS
Sbjct: 351 LEAASQQNQQLTAQLS 366
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 53.9 bits (128), Expect = 1e-06
Identities = 41/152 (26%), Positives = 65/152 (42%), Gaps = 10/152 (6%)
Query: 642 RSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKN 701
R +GPGS G + +V + + P A P P T S
Sbjct: 36 RGDAGPGS------GAASGTVVAAAAGGPGPGAGGVAAAGPAPA---PPTGGSGGSGAGG 86
Query: 702 EPLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGD 761
+ G+L K + +K ++RRWFVL G L YY+S +++ +G I L A+ +I D
Sbjct: 87 SGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINL-ATANITVED 145
Query: 762 NKQTVQLTTEKHTYYLTADSPNILEEWIKVLQ 793
+ + TY+L A S + W+ L+
Sbjct: 146 SCNFIISNGGAQTYHLKASSEVERQRWVTALE 177
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 53.5 bits (127), Expect = 1e-06
Identities = 84/385 (21%), Positives = 152/385 (39%), Gaps = 59/385 (15%)
Query: 12 DWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLK 71
+W+E+ ++ Q K R Q KIRE EKM++ E + + E EK +Q ++M +K +
Sbjct: 311 EWEEK---IQEQEEKIREQEEKIREQ-EEKMRRQEEMMWEKE---EKMRRQEEMMWEKEE 363
Query: 72 AANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIK 131
K + LE ++ EK++ I+ LE ++ EQ++IR QE K EE+ KI+
Sbjct: 364 ---------------KMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE--KIR 406
Query: 132 EWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSL 191
E + E ++ Q ++ + Q E+IR + K+ + K + + Q +
Sbjct: 407 EQEKRQEQEAKMWRQEEKI--REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 464
Query: 192 TFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEE--MEIPEKSVDNQVLENNRGQ 249
R ++ + EE+ + K E + + EE EK D + + +
Sbjct: 465 W--------RQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 250 RTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSH 309
+ Q EQ K R Q + E++ G + +
Sbjct: 517 KMWRQEEKIREQEEKIR---------EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 310 TSEEGV-QCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLG 368
EE + + E + I+E+E K E +++ Q+E W+
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWE------- 617
Query: 369 KGNSELSKKEQDSSSDELNKKFQSQ 393
E EQ+ E +K + Q
Sbjct: 618 ---QEEKMCEQEEKMQEQEEKMRRQ 639
Score = 52.0 bits (123), Expect = 4e-06
Identities = 44/168 (26%), Positives = 88/168 (52%), Gaps = 4/168 (2%)
Query: 2 AELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQ 61
A+L E V+ ++ + L + +K +++ +K+ LL ++ Q E + E Q+ A
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKL--LLPQQQLQAEADHLGKELQSVSAKL 281
Query: 62 QVQVMEDKL-KAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA 120
Q QV E++L N Q E R K Q+ E IQE+++ I+ E ++ EQ++ ++
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341
Query: 121 KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQE 168
+++ EK K++ + + E E + + L + + E+IR ++ K+ E
Sbjct: 342 EMMWEKEEKMRRQEEM-MWEKEEKMRRLEEMMWEKEEKIRELEEKMHE 388
Score = 36.6 bits (83), Expect = 0.19
Identities = 29/143 (20%), Positives = 67/143 (46%), Gaps = 10/143 (6%)
Query: 39 AEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEK 98
A +++Q V +++A++ +++ D L + + ++ L K L+ +Q
Sbjct: 174 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 233
Query: 99 DDVIQNLELQLEEQKQIRIQEAKII---------EEKAAKIKEWVTVKLNELELENQNLR 149
+ ++L ++E K+ +++ AK++ + K + V+ KL EN+
Sbjct: 234 ESEKSEIQLNVKELKR-KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292
Query: 150 LINQNQTEEIRTMQSKLQEVQGK 172
+NQ Q E++ + K+QE + K
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEK 315
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 53.5 bits (127), Expect = 1e-06
Identities = 57/262 (21%), Positives = 113/262 (43%), Gaps = 35/262 (13%)
Query: 4 LSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAE----------KMQQLERQVIDAE 53
L+E EG + + L + Q +ELL E K++QLE + +
Sbjct: 1296 LNEAEG------KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 54 RQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQK 113
Q ++ + Q +E + NIQ S+S+ +L QD S ++ ++ + + ++E
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKL----QDFASTVEALEEGKKRFQKEIENLT 1405
Query: 114 QIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKK 173
Q + +E +K K K + +L++L ++ N R + N ++ R L E +
Sbjct: 1406 Q-QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 174 SSTVSTLKLSEGQRLSSLTFGCFLSRA-----------RSPPQVVKSEEMSKISSKEPEF 222
S +E + T L+RA +++K+E +SSK+
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD--- 1521
Query: 223 TEGKDMEEMEIPEKSVDNQVLE 244
GK++ E+E +++++ Q+ E
Sbjct: 1522 DVGKNVHELEKSKRALETQMEE 1543
Score = 45.8 bits (107), Expect = 3e-04
Identities = 44/212 (20%), Positives = 96/212 (45%), Gaps = 40/212 (18%)
Query: 12 DWKERCVALESQLMKFRVQASKIRELLA-----------------EKMQQLERQVID--- 51
D+ E+ L++Q+ + ++Q +K E L +K+++LE + D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 52 -----------AERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDD 100
AE+Q ++++ ++ +L+ T+ + + Q++ L + D+
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 101 VIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIR 160
++ E Q++E +Q + A+ +EE +++++ K N L+ Q L N + E+R
Sbjct: 1186 ETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENADLAGELR 1241
Query: 161 TMQSKLQEVQGKKSSTVSTL-----KLSEGQR 187
+ QEV+ KK + + K S+G+R
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Score = 43.9 bits (102), Expect = 0.001
Identities = 78/401 (19%), Positives = 167/401 (41%), Gaps = 41/401 (10%)
Query: 38 LAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQE 97
+ + + +LE+ E Q E+ Q++ +ED+L+A E + E +Q
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 98 KDDVIQNLELQLEEQKQIRIQEAKIIEEK-----AAKIKEWVTVKLNELELENQNLRLIN 152
+D+ QN E + + Q+Q+ E ++ +E+ AA K+ + L +LEL+ +
Sbjct: 1583 RDE--QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 153 QNQTEEIRTMQS-------KLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCF--------L 197
+ +++R +Q+ +L++ + + +T K +E ++ SL
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE-KKAKSLEADLMQLQEDLAAA 1699
Query: 198 SRARSPPQVVK---SEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQ 254
RAR + K +EE++ S + K E I + + + + N + +
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM-EAMSDR 1758
Query: 255 TPCGSEQNRKTRTSFATDGGISQ-NSGAPVSDWSSDEEDGSK-----GRSKSRCTSTLSS 308
++Q + AT+ +Q N A ++E SK G KS+ ST+++
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818
Query: 309 HTS-----EEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKAL 363
+ EE V+ + + +E + E ++ + Q + Q +
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV---EDERKMAEQYKEQAEKG 1875
Query: 364 NSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEA 404
N+ + + +L + E++S N++ + LD ++ S+EA
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Score = 38.5 bits (88), Expect = 0.049
Identities = 52/295 (17%), Positives = 136/295 (46%), Gaps = 35/295 (11%)
Query: 15 ERCVALESQLMKFRVQASKIR--ELLAE-KMQQLERQVIDAERQAEKAFQQVQVMEDKLK 71
++ + LE QL + K++ ++ AE K+++LE +++ + Q K ++ +++E+++
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Query: 72 AANIQTSESE------TRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEE 125
+E E T+L NK + +I LE++L+++++ R QE + ++
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNK----------HESMISELEVRLKKEEKSR-QELEKLKR 1058
Query: 126 KAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEG 185
K ++ +L+ + L++ + EE++ ++L + +K++ + ++ EG
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 186 QRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIP-EKSVDNQVLE 244
+S L + + SE ++ +++ + G+++E ++ E ++D+ +
Sbjct: 1119 -HISDL------------QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 245 NN-RGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRS 298
R +R T + +TR+ A + Q V + + E + ++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Score = 37.0 bits (84), Expect = 0.14
Identities = 29/154 (18%), Positives = 71/154 (46%), Gaps = 13/154 (8%)
Query: 35 RELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESL 94
++ L ++Q+L+ + D ER + +V +++++++ +E+E + +D+ SL
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 95 IQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQN 154
+ D + L+ + ++ + + ++ EE+ N L+ + QN
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEER------------NSLQDQLDEEMEAKQN 1361
Query: 155 QTEEIRTMQSKLQEVQGKKSSTVSTLK-LSEGQR 187
I T+ +L + + K ST++ L EG++
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Score = 36.2 bits (82), Expect = 0.24
Identities = 41/190 (21%), Positives = 92/190 (48%), Gaps = 25/190 (13%)
Query: 3 ELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKM---QQLERQVIDAERQAEKA 59
EL E +G ++ A+ ++ K QA ++ LA + Q+ E ERQ ++
Sbjct: 1744 ELEEEQGNME------AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 60 FQQVQVMEDKLK--------AANIQTSESETRLYNKCQDLESL---IQEKDDVIQNLELQ 108
++ ME +K A + ++ E ++ + ++ ++ +++KD ++ + LQ
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 109 LEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQ----NLRLINQNQTEEIRTMQS 164
+E+++++ Q + E+ A++K+ + +L E E E+Q N R + + E + ++
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQ-LKRQLEEAEEESQRINANRRKLQRELDEATESNEA 1916
Query: 165 KLQEVQGKKS 174
+EV KS
Sbjct: 1917 MGREVNALKS 1926
Score = 35.0 bits (79), Expect = 0.54
Identities = 75/416 (18%), Positives = 157/416 (37%), Gaps = 68/416 (16%)
Query: 55 QAEKAFQQVQVMEDKL--------KAAN-------------------IQTSESETRLYNK 87
Q + +++Q ED+L KA N + ++ET LY +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 88 CQDLESLI----QEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELEL 143
+++ + QE ++++ +E +LEE++ R Q+ + +K A+ + +L E E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEED-RGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 144 ENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCFLSRARSP 203
Q L+L +I+ ++ ++ + + + KL E +R+S LT ++
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE-ERISDLTTNLAEEEEKAK 1023
Query: 204 PQV-VKSEEMSKISSKEPEF-TEGKDMEEMEIPEKSVD------NQVLENNRGQRTLHQT 255
+K++ S IS E E K +E+E ++ ++ ++ + + + Q +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 256 PCGSEQNRKTRTSFATDGGISQNSGA---------PVSDWSSDEEDGSKGRS-------- 298
++ D I+Q + A +SD D + R+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 299 --------KSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKK 350
K+ TL S +++ ++ R L + D + E R +H +
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 351 LYS--WQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEA 404
+Q Q+K + L K L K+ D + + Q +++ EA
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Score = 33.9 bits (76), Expect = 1.2
Identities = 108/515 (20%), Positives = 187/515 (36%), Gaps = 95/515 (18%)
Query: 21 ESQLMKFRVQASKIRELLAEKMQQ--------------LERQVIDAERQAEKAFQQVQVM 66
E+Q+ + R + ++ E L E+++Q LE++ D + Q Q +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 67 EDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEK 126
E K K Q E L +KC D E E +D + L+ ++E
Sbjct: 1251 EHKKKKLEAQVQE----LQSKCSDGERARAELNDKVHKLQNEVES--------------- 1291
Query: 127 AAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQ 186
VT LNE E + L + + +++ Q LQE +K + + L+ E +
Sbjct: 1292 -------VTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 187 RLS-------SLTFGCFLSRARSPPQVVKSEEMSKI---SSKEPEFTEGKDMEEMEI--- 233
R S + L R S + S+ K+ +S EGK + EI
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 234 ----PEKSVDNQVLE--NNRGQRTLHQTPCGSEQNRKTRTSFAT-----DGGISQNSGAP 282
EK+ LE NR Q+ L + R+ ++ D +++
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN-- 1462
Query: 283 VSDWSSDEEDGSKGRSKSRCTSTLS-SHTSEEGVQCSR--------MGSEMY-LTASDDS 332
+S +DE D ++ ++ + T LS + EE ++ + +EM L +S D
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD 1522
Query: 333 SSIFEEETFGIKRP-----EHKKLYSWQQEAQWKA---------LNSPLGKGNSELSKKE 378
E KR E K + E + +A +N KG E +
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 379 QDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPP 438
+D ++E ++ Q Q +Y + E L A K L K +L S +
Sbjct: 1583 RDEQNEEKRRQLQRQLHEY-ETELEDERKQRALAAAAKKKLEGDL--KDLELQADSAIKG 1639
Query: 439 PKLRIPNVFSISVALA--KRHLSQPQLSSDRMFGT 471
+ I + + + +R L + S D +F T
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,886,557
Number of Sequences: 37866
Number of extensions: 2763205
Number of successful extensions: 14159
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 783
Number of HSP's that attempted gapping in prelim test: 10442
Number of HSP's gapped (non-prelim): 3459
length of query: 1493
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1378
effective length of database: 13,892,928
effective search space: 19144454784
effective search space used: 19144454784
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.