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Search of human proteins with 21735544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
(419 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 850 0.0
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 293 2e-79
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 266 2e-71
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 259 2e-69
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 259 2e-69
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 206 3e-53
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 202 6e-52
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 192 6e-49
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 169 3e-42
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 157 1e-38
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 154 1e-37
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 152 4e-37
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 147 2e-35
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 146 4e-35
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 141 1e-33
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 140 2e-33
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 135 5e-32
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 134 2e-31
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 131 1e-30
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 131 1e-30
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 131 1e-30
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 131 1e-30
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 131 1e-30
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 131 1e-30
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 131 1e-30
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 131 1e-30
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 131 1e-30
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 127 1e-29
gi|145275208 myosin IIIA [Homo sapiens] 126 4e-29
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 124 2e-28
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 850 bits (2195), Expect = 0.0
Identities = 419/419 (100%), Positives = 419/419 (100%)
Query: 1 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES 60
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
Sbjct: 1 MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES 60
Query: 61 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL 120
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
Sbjct: 61 SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL 120
Query: 121 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV 180
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
Sbjct: 121 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV 180
Query: 181 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI 240
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
Sbjct: 181 QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI 240
Query: 241 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD 300
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
Sbjct: 241 HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD 300
Query: 301 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC 360
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
Sbjct: 301 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC 360
Query: 361 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR 419
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Sbjct: 361 LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR 419
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 293 bits (750), Expect = 2e-79
Identities = 159/317 (50%), Positives = 212/317 (66%), Gaps = 8/317 (2%)
Query: 84 PRSMESIEIDQKLQEIMKQTGYLTIGG-QRYQAEINDLENLGEMGSGTCGQVWKMRFRKT 142
P +++ I++ ++ +G L I Q + DL++LGE+G G G V KM + +
Sbjct: 65 PTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPS 124
Query: 143 GHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTC 202
G ++AVK++R + +++E K++LMDLDVV++S DCPYIVQ +G D +I MELM T
Sbjct: 125 GQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS 184
Query: 203 AEKLKKR----MQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIK 258
+K K + IPE ILGK+T+A VKAL +LKE +IHRD+KPSNILLD G IK
Sbjct: 185 FDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIK 244
Query: 259 LCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATG 318
LCDFGISG+LVDS AKTR AGC YMAPERID P ++ YD+R+DVWSLGI+L ELATG
Sbjct: 245 LCDFGISGQLVDSIAKTRDAGCRPYMAPERID-PSASRQGYDVRSDVWSLGITLYELATG 303
Query: 319 QFPYKNCKTDFEVLTKVLQEEPPLLPG--HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE 376
+FPY + F+ LT+V++ +PP L FS F +FV CLTKD KRPKY +LL+
Sbjct: 304 RFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK 363
Query: 377 HSFIKRYETLEVDVASW 393
H FI YE V+VA +
Sbjct: 364 HPFILMYEERAVEVACY 380
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 266 bits (681), Expect = 2e-71
Identities = 137/296 (46%), Positives = 199/296 (67%), Gaps = 5/296 (1%)
Query: 106 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILM 165
++IG Q ++ + +DLE + E+G G G V KMR +G ++AVK++R + N +E KR+LM
Sbjct: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98
Query: 166 DLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGKM 222
DLD+ +++ DCP+ V +G DV+I MELM T +K K++ IPE ILGK+
Sbjct: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158
Query: 223 TVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA 282
V+IVKAL +L K VIHRDVKPSN+L++ GQ+K+CDFGISG LVDS AKT AGC
Sbjct: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218
Query: 283 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 342
YMAPERI+ P+ + Y +++D+WSLGI+++ELA +FPY + T F+ L +V++E P
Sbjct: 219 YMAPERIN-PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277
Query: 343 LPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVM 398
LP FS +F F CL K+ ++RP Y +L++H F +E+ DVAS+ K ++
Sbjct: 278 LPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 332
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 259 bits (663), Expect = 2e-69
Identities = 130/299 (43%), Positives = 202/299 (67%), Gaps = 5/299 (1%)
Query: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
++TIG + ++ E +DL + E+G G G V K+R ++G ++AVK++R + N +E KR+L
Sbjct: 20 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 79
Query: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 80 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 139
Query: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT AGC
Sbjct: 140 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 199
Query: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPP 341
YMAPERI+ P+ + Y++++DVWSLGI+++E+A +FPY++ T F+ L +V++E P
Sbjct: 200 PYMAPERIN-PELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSP 258
Query: 342 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK 400
LP FS +F F CL K+ +R Y +L+EH F ++T + D+A++ K+++ +
Sbjct: 259 QLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 316
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 259 bits (663), Expect = 2e-69
Identities = 130/299 (43%), Positives = 202/299 (67%), Gaps = 5/299 (1%)
Query: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
++TIG + ++ E +DL + E+G G G V K+R ++G ++AVK++R + N +E KR+L
Sbjct: 49 FITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLL 108
Query: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 168
Query: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT AGC
Sbjct: 169 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 228
Query: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPP 341
YMAPERI+ P+ + Y++++DVWSLGI+++E+A +FPY++ T F+ L +V++E P
Sbjct: 229 PYMAPERIN-PELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSP 287
Query: 342 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK 400
LP FS +F F CL K+ +R Y +L+EH F ++T + D+A++ K+++ +
Sbjct: 288 QLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGE 345
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 206 bits (524), Expect = 3e-53
Identities = 126/354 (35%), Positives = 200/354 (56%), Gaps = 59/354 (16%)
Query: 85 RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH 144
+ +E +E+D+ Q+ + +LT + + + +D E + E+G+G G V+K+ + +G
Sbjct: 35 KKLEELELDE--QQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGL 92
Query: 145 VIAVKQMRRSGNKEENKRILMDLDVVLKSHDC--PYIVQCFGTFITNTDVFIAMELM--G 200
V+A K + +I+ +L V+ H+C PYIV +G F ++ ++ I ME M G
Sbjct: 93 VMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEHMDGG 149
Query: 201 TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLC 260
+ + LKK G IPE+ILGK+++A++K L YL+EKH ++HRDVKPSNIL++ RG+IKLC
Sbjct: 150 SLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLC 207
Query: 261 DFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF 320
DFG+SG+L+DS A + G +YM+PER+ Y +++D+WS+G+SLVE+A G++
Sbjct: 208 DFGVSGQLIDSMANS-FVGTRSYMSPERLQ-----GTHYSVQSDIWSMGLSLVEMAVGRY 261
Query: 321 PYK-----------NCKTD------------------------------FEVLTKVLQEE 339
P C+ + FE+L ++ E
Sbjct: 262 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP 321
Query: 340 PPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASW 393
PP LP + FS +FQ FV CL K+ +R +L+ H+FIKR + EVD A W
Sbjct: 322 PPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGW 374
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 202 bits (513), Expect = 6e-52
Identities = 125/358 (34%), Positives = 195/358 (54%), Gaps = 63/358 (17%)
Query: 85 RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGH 144
+ +E +E+D+ Q+ + +LT + + + +D E + E+G+G G V K++ R +G
Sbjct: 39 KKLEELELDE--QQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGL 96
Query: 145 VIAVKQMRRSGNKEENKRILMDLDVVLKSHDC--PYIVQCFGTFITNTDVFIAMELM--G 200
++A K + +I+ +L V+ H+C PYIV +G F ++ ++ I ME M G
Sbjct: 97 IMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEHMDGG 153
Query: 201 TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLC 260
+ + LK+ + IPE ILGK+++A+++ L YL+EKH ++HRDVKPSNIL++ RG+IKLC
Sbjct: 154 SLDQVLKEAKR--IPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLC 211
Query: 261 DFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQF 320
DFG+SG+L+DS A + G +YMAPER+ Y +++D+WS+G+SLVELA G++
Sbjct: 212 DFGVSGQLIDSMANS-FVGTRSYMAPERLQ-----GTHYSVQSDIWSMGLSLVELAVGRY 265
Query: 321 PY---------------------------------------------KNCKTDFEVLTKV 335
P + FE+L +
Sbjct: 266 PIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYI 325
Query: 336 LQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASW 393
+ E PP LP + F+ DFQ FV CL K+ +R L H+FIKR E EVD A W
Sbjct: 326 VNEPPPKLPNGV-FTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGW 382
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 192 bits (487), Expect = 6e-49
Identities = 98/211 (46%), Positives = 143/211 (67%), Gaps = 4/211 (1%)
Query: 105 YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRIL 164
++TIG ++ E +DL + E+G G G V K+R ++G ++AVK + + N E KR+L
Sbjct: 54 FITIGDTNFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLL 113
Query: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 173
Query: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AK AGC
Sbjct: 174 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCK 233
Query: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISL 312
YMAPERI+ P+ + Y++++DVWSLGI++
Sbjct: 234 PYMAPERIN-PELNQKGYNVKSDVWSLGITM 263
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 169 bits (429), Expect = 3e-42
Identities = 114/322 (35%), Positives = 176/322 (54%), Gaps = 25/322 (7%)
Query: 78 PSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKM 137
PS +P +S+ L++ + + GQ + +I + LG GT V+K
Sbjct: 128 PSQHSSPAVSDSLP-SNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGT---VYKA 183
Query: 138 RFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAME 197
+G ++AVK + E K+I+ +L+++ K D YI+ +G F + I E
Sbjct: 184 YHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTE 242
Query: 198 LMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257
M + + ++M PE +LG++ VA+VK L YL ++HRDVKPSN+L++ RGQ+
Sbjct: 243 FMDGGSLDVYRKM----PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQV 297
Query: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317
KLCDFG+S +LV+S AKT G AYMAPERI + Y I +DVWSLGIS +ELA
Sbjct: 298 KLCDFGVSTQLVNSIAKT-YVGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMELAL 351
Query: 318 GQFPYKNCKTD------FEVLTKVLQEEPPLLPGHMG-FSGDFQSFVKDCLTKDHRKRPK 370
G+FPY + + ++L ++ E+ P+LP +G FS F F+ C+ K ++RP
Sbjct: 352 GRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLP--VGEFSEPFVHFITQCMRKQPKERPA 409
Query: 371 YNKLLEHSFIKRYETLEVDVAS 392
+L+ H FI ++ V S
Sbjct: 410 PEELMGHPFIVQFNDGNAAVVS 431
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 157 bits (398), Expect = 1e-38
Identities = 109/316 (34%), Positives = 169/316 (53%), Gaps = 23/316 (7%)
Query: 78 PSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKM 137
PS +P +S+ L++ + + GQ + +I + LG GT V+K
Sbjct: 128 PSQHSSPAVSDSLP-SNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGT---VYKA 183
Query: 138 RFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAME 197
+G ++AVK + E K+I+ +L+++ K D YI+ +G F + I E
Sbjct: 184 YHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTE 242
Query: 198 LMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257
M + + ++M PE +LG++ VA+VK L YL ++HRDVKPSN+L++ RGQ+
Sbjct: 243 FMDGGSLDVYRKM----PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQV 297
Query: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317
KLCDFG+S +LV+S AKT G AYMAPERI + Y I +DVWSLGIS +E+
Sbjct: 298 KLCDFGVSTQLVNSIAKT-YVGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMEIQK 351
Query: 318 GQFPYKNCKTDFEVLTKVLQEEPPLLPGHMG-FSGDFQSFVKDCLTKDHRKRPKYNKLLE 376
Q ++L ++ E+ P+LP +G FS F F+ C+ K ++RP +L+
Sbjct: 352 NQ----GSLMPLQLLQCIVDEDSPVLP--VGEFSEPFVHFITQCMRKQPKERPAPEELMG 405
Query: 377 HSFIKRYETLEVDVAS 392
H FI ++ V S
Sbjct: 406 HPFIVQFNDGNAAVVS 421
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 154 bits (390), Expect = 1e-37
Identities = 97/262 (37%), Positives = 147/262 (56%), Gaps = 12/262 (4%)
Query: 123 LGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 182
L +G G+ G+V+K T V+A+K + ++E + I ++ VL D PYI +
Sbjct: 23 LDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEI-TVLSQCDSPYITRY 81
Query: 183 FGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHR 242
FG+++ +T ++I ME +G L GP+ E + + I+K L YL + IHR
Sbjct: 82 FGSYLKSTKLWIIMEYLGG-GSALDLLKPGPLEETYIATILREILKGLDYLHSERK-IHR 139
Query: 243 DVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPDYDI 301
D+K +N+LL E+G +KL DFG++G+L D++ K + G +MAPE I + YD
Sbjct: 140 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-----KQSAYDF 194
Query: 302 RADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCL 361
+AD+WSLGI+ +ELA G+ P + VL + + PP L G S F+ FV+ CL
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLH-PMRVLFLIPKNSPPTLEGQ--HSKPFKEFVEACL 251
Query: 362 TKDHRKRPKYNKLLEHSFIKRY 383
KD R RP +LL+H FI RY
Sbjct: 252 NKDPRFRPTAKELLKHKFITRY 273
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 152 bits (385), Expect = 4e-37
Identities = 77/151 (50%), Positives = 107/151 (70%), Gaps = 4/151 (2%)
Query: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221
MDLD+ +++ DC Y V +G DV+I MELM T +K +++ IPE ILG+
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
Query: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281
+ V+IV+AL +L K VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT AGC
Sbjct: 61 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
Query: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISL 312
YMAPERI+ P+ + Y++++DVWSLGI++
Sbjct: 121 PYMAPERIN-PELNQKGYNVKSDVWSLGITM 150
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 147 bits (371), Expect = 2e-35
Identities = 95/276 (34%), Positives = 156/276 (56%), Gaps = 13/276 (4%)
Query: 109 GGQRYQAEINDL-ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDL 167
G Q +A+ +L L ++G G+ G+V+K +T V+A+K + ++E + I ++
Sbjct: 12 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 71
Query: 168 DVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIV 227
VL D PY+ + +G+++ +T ++I ME +G L GP+ E + + I+
Sbjct: 72 -TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG-GSALDLLEPGPLDETQIATILREIL 129
Query: 228 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAP 286
K L YL + IHRD+K +N+LL E G++KL DFG++G+L D++ K + G +MAP
Sbjct: 130 KGLDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 287 ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGH 346
E I + YD +AD+WSLGI+ +ELA G+ P+ +VL + + PP L G+
Sbjct: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELH-PMKVLFLIPKNNPPTLEGN 242
Query: 347 MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 382
+S + FV+ CL K+ RP +LL+H FI R
Sbjct: 243 --YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILR 276
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 146 bits (368), Expect = 4e-35
Identities = 94/276 (34%), Positives = 155/276 (56%), Gaps = 13/276 (4%)
Query: 109 GGQRYQAEINDL-ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDL 167
G +A+ +L L ++G G+ G+V+K +T V+A+K + ++E + I ++
Sbjct: 24 GSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 83
Query: 168 DVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIV 227
VL D PY+ + +G+++ +T ++I ME +G L GP+ E + + I+
Sbjct: 84 -TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG-GSALDLLEPGPLDETQIATILREIL 141
Query: 228 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAP 286
K L YL + IHRD+K +N+LL E G++KL DFG++G+L D++ K + G +MAP
Sbjct: 142 KGLDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 287 ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGH 346
E I + YD +AD+WSLGI+ +ELA G+ P+ +VL + + PP L G+
Sbjct: 201 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELH-PMKVLFLIPKNNPPTLEGN 254
Query: 347 MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 382
+S + FV+ CL K+ RP +LL+H FI R
Sbjct: 255 --YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILR 288
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 141 bits (356), Expect = 1e-33
Identities = 91/285 (31%), Positives = 162/285 (56%), Gaps = 21/285 (7%)
Query: 123 LGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 182
L ++G G+ G V+K +++G V+A+KQ+ + +E I+ ++ + ++ D PY+V+
Sbjct: 30 LEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE---IIKEISI-MQQCDSPYVVKY 85
Query: 183 FGTFITNTDVFIAMELMG--TCAEKLKKRMQGPIPERI--LGKMTVAIVKALYYLKEKHG 238
+G++ NTD++I ME G + ++ ++ R + I + I + K T+ ++ L+++++
Sbjct: 86 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRK--- 142
Query: 239 VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSA-GCAAYMAPERIDPPDPTKP 297
IHRD+K NILL+ G KL DFG++G+L D+ AK + G +MAPE I +
Sbjct: 143 -IHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-----EI 196
Query: 298 DYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFV 357
Y+ AD+WSLGI+ +E+A G+ PY + + + PP +S DF FV
Sbjct: 197 GYNCVADIWSLGITSIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPELWSDDFTDFV 255
Query: 358 KDCLTKDHRKRPKYNKLLEHSFIKRYETLEV--DVASWFKDVMAK 400
K CL K+ +R +LL+H FIK + + + D+ + ++ AK
Sbjct: 256 KKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK 300
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 140 bits (354), Expect = 2e-33
Identities = 90/259 (34%), Positives = 142/259 (54%), Gaps = 12/259 (4%)
Query: 123 LGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 182
L +G G+ G+V+K +T V+A+K + ++E + I ++ VL D Y+ +
Sbjct: 27 LERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEI-TVLSQCDSSYVTKY 85
Query: 183 FGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHR 242
+G+++ + ++I ME +G L GP E + M I+K L YL + IHR
Sbjct: 86 YGSYLKGSKLWIIMEYLGG-GSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKK-IHR 143
Query: 243 DVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPDYDI 301
D+K +N+LL E+G +KL DFG++G+L D++ K + G +MAPE I + YD
Sbjct: 144 DIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQ-----QSAYDS 198
Query: 302 RADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCL 361
+AD+WSLGI+ +ELA G+ P + VL + + PP L G F+ F+ F+ CL
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMH-PMRVLFLIPKNNPPTLVG--DFTKSFKEFIDACL 255
Query: 362 TKDHRKRPKYNKLLEHSFI 380
KD RP +LL+H FI
Sbjct: 256 NKDPSFRPTAKELLKHKFI 274
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 135 bits (341), Expect = 5e-32
Identities = 88/284 (30%), Positives = 153/284 (53%), Gaps = 15/284 (5%)
Query: 123 LGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 182
L ++G G+ G V+K ++TG ++A+KQ+ + +E I+ ++ + ++ D P++V+
Sbjct: 33 LEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE---IIKEISI-MQQCDSPHVVKY 88
Query: 183 FGTFITNTDVFIAMELMGTCAEKLKKRMQGP-IPERILGKMTVAIVKALYYLKEKHGVIH 241
+G++ NTD++I ME G + R++ + E + + + +K L YL IH
Sbjct: 89 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRK-IH 147
Query: 242 RDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSA-GCAAYMAPERIDPPDPTKPDYD 300
RD+K NILL+ G KL DFG++G+L D+ AK + G +MAPE I + Y+
Sbjct: 148 RDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ-----EIGYN 202
Query: 301 IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC 360
AD+WSLGI+ +E+A G+ PY + + + PP +S +F FVK C
Sbjct: 203 CVADIWSLGITAIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 261
Query: 361 LTKDHRKRPKYNKLLEHSFIKRYETLEV--DVASWFKDVMAKTE 402
L K +R +LL+H F++ + + + D+ + DV K +
Sbjct: 262 LVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQ 305
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 134 bits (337), Expect = 2e-31
Identities = 91/270 (33%), Positives = 146/270 (54%), Gaps = 9/270 (3%)
Query: 119 DLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPY 178
D E + +GSGT G V+K R TG + A+K ++ E+ ++ +++K P
Sbjct: 15 DFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPG--EDFAVVQQEIIMMKDCKHPN 72
Query: 179 IVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG 238
IV FG+++ ++I ME G + + + GP+ E + ++ ++ LYYL K G
Sbjct: 73 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK-G 131
Query: 239 VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKP 297
+HRD+K +NILL + G +KL DFG+S ++ + AK +S G +MAPE K
Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPE--VAAVERKG 189
Query: 298 DYDIRADVWSLGISLVELATGQFPYKNC--KTDFEVLTKVLQEEPPLLPGHMGFSGDFQS 355
Y+ D+W++GI+ +ELA Q P + ++TK +PP L M +S F
Sbjct: 190 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTK-SNFQPPKLKDKMKWSNSFHH 248
Query: 356 FVKDCLTKDHRKRPKYNKLLEHSFIKRYET 385
FVK LTK+ +KRP KLL+H F+ ++ T
Sbjct: 249 FVKMALTKNPKKRPTAEKLLQHPFVTQHLT 278
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 131 bits (330), Expect = 1e-30
Identities = 90/293 (30%), Positives = 156/293 (53%), Gaps = 9/293 (3%)
Query: 121 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV 180
E +GE+G G G+V+K + ++TG + A K + ++EE + ++++++ L + D PYIV
Sbjct: 37 EIVGELGDGAFGKVYKAKNKETGALAAAKVIETK-SEEELEDYIVEIEI-LATCDHPYIV 94
Query: 181 QCFGTFITNTDVFIAMELM-GTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGV 239
+ G + + ++I +E G + + + + E + + +++AL +L K +
Sbjct: 95 KLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR-I 153
Query: 240 IHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPD 298
IHRD+K N+L+ G I+L DFG+S + + + K S G +MAPE +
Sbjct: 154 IHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 213
Query: 299 YDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVK 358
YD +AD+WSLGI+L+E+A + P+ VL K+ + +PP L +S +F+ F+K
Sbjct: 214 YDYKADIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 272
Query: 359 DCLTKDHRKRPKYNKLLEHSFIKRY---ETLEVDVASWFKDVMAKTESPRTSG 408
L K+ RP +LLEH F+ + L VA +VM + E R G
Sbjct: 273 IALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEG 325
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 131 bits (329), Expect = 1e-30
Identities = 92/289 (31%), Positives = 151/289 (52%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M +G++EE I +++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI +++ ME G + + +K + E + + I++ L +L + H
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ-H 147
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 148 KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD ++D+WSLGI+ +E+A G P + L + + P L +S FQSF
Sbjct: 208 ATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMRALFLIPRNPAPRLKSKK-WSKKFQSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K+H +RP +L++H FI R + E V KD + +T+ R
Sbjct: 266 IESCLVKNHSQRPATEQLMKHPFI-RDQPNERQVRIQLKDHIDRTKKKR 313
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 127 bits (320), Expect = 1e-29
Identities = 85/262 (32%), Positives = 143/262 (54%), Gaps = 6/262 (2%)
Query: 121 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV 180
E +GE+G G G+V+K + ++T V+A ++ + ++EE + ++++D+ L S D P IV
Sbjct: 35 EIIGELGDGAFGKVYKAQNKETS-VLAAAKVIDTKSEEELEDYMVEIDI-LASCDHPNIV 92
Query: 181 QCFGTFITNTDVFIAMELM-GTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGV 239
+ F +++I +E G + + ++ P+ E + + + AL YL + +
Sbjct: 93 KLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNK-I 151
Query: 240 IHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPD 298
IHRD+K NIL G IKL DFG+S + + + S G +MAPE +
Sbjct: 152 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 211
Query: 299 YDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVK 358
YD +ADVWSLGI+L+E+A + P+ VL K+ + EPP L +S +F+ F+K
Sbjct: 212 YDYKADVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLK 270
Query: 359 DCLTKDHRKRPKYNKLLEHSFI 380
CL K+ R ++LL+H F+
Sbjct: 271 KCLEKNVDARWTTSQLLQHPFV 292
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 126 bits (316), Expect = 4e-29
Identities = 91/279 (32%), Positives = 141/279 (50%), Gaps = 26/279 (9%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G GT G+V+K+ +K G AVK + + +E I + +++ D P +V+ +G
Sbjct: 27 IGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEE--IEAEYNILKALSDHPNVVRFYGI 84
Query: 186 F-----ITNTDVFIAMELM--GTCAEKLK------KRMQGPIPERILGKMTVAIVKALYY 232
+ + +++ +EL G+ + +K +RM P+ IL + AL
Sbjct: 85 YFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHE-------ALMG 137
Query: 233 LKEKHG--VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSK-AKTRSAGCAAYMAPERI 289
L+ H IHRDVK +NILL G +KL DFG+S +L ++ + S G +MAPE I
Sbjct: 138 LQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVI 197
Query: 290 DPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGF 349
YD R D WSLGI+ +EL G P + L K+ + PP L +
Sbjct: 198 ACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHP-MRALFKIPRNPPPKLRQPELW 256
Query: 350 SGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEV 388
S +F F+ CLTKD+ KRP ++LL+H FI + E +V
Sbjct: 257 SAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDV 295
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 124 bits (311), Expect = 2e-28
Identities = 91/289 (31%), Positives = 150/289 (51%), Gaps = 15/289 (5%)
Query: 126 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGT 185
+G+GT GQV+K R KTG + A+K M + ++EE I ++++++ K I +G
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE--IKLEINMLKKYSHHRNIATYYGA 88
Query: 186 FITNT------DVFIAMELMG--TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 237
FI + +++ ME G + + +K + E + ++ I++ L +L H
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148
Query: 238 GVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTK 296
VIHRD+K N+LL E ++KL DFG+S +L + + + G +MAPE I +
Sbjct: 149 -VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPD 207
Query: 297 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 356
YD R+D+WS GI+ +E+A G P + L + + PP L +S F SF
Sbjct: 208 ATYDYRSDLWSCGITAIEMAEGAPPLCDMH-PMRALFLIPRNPPPRLKSKK-WSKKFFSF 265
Query: 357 VKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPR 405
++ CL K++ +RP +LL+H FI R + E V KD + +T R
Sbjct: 266 IEGCLVKNYMQRPSTEQLLKHPFI-RDQPNERQVRIQLKDHIDRTRKKR 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,359,629
Number of Sequences: 37866
Number of extensions: 847705
Number of successful extensions: 6235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 596
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 4323
Number of HSP's gapped (non-prelim): 1060
length of query: 419
length of database: 18,247,518
effective HSP length: 105
effective length of query: 314
effective length of database: 14,271,588
effective search space: 4481278632
effective search space used: 4481278632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.