Guide to the Human Genome
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Search of human proteins with 21735417

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
         (824 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]            1582   0.0  
gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]            1580   0.0  
gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]             973   0.0  
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]             973   0.0  
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   109   9e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]               102   1e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    96   2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    96   2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    96   2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    96   2e-19
gi|71061468 centromere protein E [Homo sapiens]                        90   1e-17
gi|21735548 centrosomal protein 2 [Homo sapiens]                       89   1e-17
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         89   2e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    86   1e-16
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     85   2e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    83   9e-16
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    83   9e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    83   1e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     83   1e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    81   5e-15
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    80   6e-15
gi|38044112 restin isoform b [Homo sapiens]                            80   8e-15
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         80   8e-15
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         80   8e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             80   8e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    80   1e-14
gi|4506751 restin isoform a [Homo sapiens]                             80   1e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     79   1e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       78   3e-14
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    78   4e-14

>gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
          Length = 824

 Score = 1582 bits (4095), Expect = 0.0
 Identities = 824/824 (100%), Positives = 824/824 (100%)

Query: 1   MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
           MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
Sbjct: 1   MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60

Query: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
           FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
Sbjct: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120

Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
           LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
Sbjct: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180

Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
           YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
Sbjct: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240

Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
           EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
Sbjct: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300

Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
           NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
Sbjct: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360

Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
           GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
Sbjct: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420

Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
           DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
Sbjct: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480

Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
           LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
Sbjct: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540

Query: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
           VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
Sbjct: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600

Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
           GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
Sbjct: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660

Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
           LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720

Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
           MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780

Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
           LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824


>gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]
          Length = 855

 Score = 1580 bits (4092), Expect = 0.0
 Identities = 823/824 (99%), Positives = 824/824 (100%)

Query: 1   MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
           MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
Sbjct: 1   MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60

Query: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
           FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
Sbjct: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120

Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
           LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
Sbjct: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180

Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
           YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
Sbjct: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240

Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
           EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
Sbjct: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300

Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
           NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
Sbjct: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360

Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
           GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
Sbjct: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420

Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
           DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
Sbjct: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480

Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
           LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
Sbjct: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540

Query: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
           VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
Sbjct: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600

Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
           GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
Sbjct: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660

Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
           LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720

Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
           MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780

Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
           LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPS+
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSV 824


>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
          Length = 835

 Score =  973 bits (2516), Expect = 0.0
 Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)

Query: 23  RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
           + E++RL+ EL ETT EKIQAAEYGL VLEEK  LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 14  KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73

Query: 83  GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
           GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 74  GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133

Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
            +V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193

Query: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262
           VE+EGLKHEIKR EEET  LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253

Query: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322
            Y+S+ND    +H+ +S+DGLKF++D +EPNND +  +NG  HG L KL  D +T T +K
Sbjct: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307

Query: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
            E L P     VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362

Query: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
           EQ E+V RLTE+++A+R LQ+SKE +  LD EK RDS E+   YEVDING EIL CKY V
Sbjct: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422

Query: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501
           AV E  +L+ ++KAL+  +      + +EK +YE++ Q   E+V+ LEK +++  E +A 
Sbjct: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482

Query: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561
           +EKEL+K++ +A E   +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542

Query: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616
                T  G    P + RG  SP L  +G+ +P   R          +  S  PSP    
Sbjct: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598

Query: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
                            SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658

Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
           L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718

Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
           MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778

Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
           LLRMAIQQKLALTQRLE LE DHEQ+RR + K   K+K  +P +
Sbjct: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKI 821


>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
          Length = 975

 Score =  973 bits (2515), Expect = 0.0
 Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)

Query: 23  RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
           + E++RL+ EL ETT EKIQAAEYGL VLEEK  LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 14  KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73

Query: 83  GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
           GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 74  GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133

Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
            +V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193

Query: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262
           VE+EGLKHEIKR EEET  LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253

Query: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322
            Y+S+ND    +H+ +S+DGLKF++D +EPNND +  +NG  HG L KL  D +T T +K
Sbjct: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307

Query: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
            E L P     VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362

Query: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
           EQ E+V RLTE+++A+R LQ+SKE +  LD EK RDS E+   YEVDING EIL CKY V
Sbjct: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422

Query: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501
           AV E  +L+ ++KAL+  +      + +EK +YE++ Q   E+V+ LEK +++  E +A 
Sbjct: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482

Query: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561
           +EKEL+K++ +A E   +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542

Query: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616
                T  G    P + RG  SP L  +G+ +P   R          +  S  PSP    
Sbjct: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598

Query: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
                            SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658

Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
           L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718

Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
           MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778

Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
           LLRMAIQQKLALTQRLE LE DHEQ+RR + K   K+K  +P +
Sbjct: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKV 821


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  109 bits (273), Expect = 9e-24
 Identities = 182/826 (22%), Positives = 358/826 (43%), Gaps = 112/826 (13%)

Query: 57   LKLQFEELEVDYEAIRSEMEQ----LKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
            LKL+ +EL+ + E+++S+M+Q    L+    QA   H K   + + + ++L +E    E+
Sbjct: 2099 LKLK-KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157

Query: 113  YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
                  + L  + K+++ +  N  S   +LA+  + +  +  +    R R+ D+ K+++ 
Sbjct: 2158 TIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD----RDRVIDEAKKWER 2213

Query: 173  REARLLQDYSE---LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDA 229
            + +  +Q   E   L+E+N S+ K    LRQ  +  E LK  I RLE + +   S+ +  
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQ--LRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271

Query: 230  IRLKEISERQLEEALETLKTEREQKNSLRKELSH--YMSIND-SFYTSHLHVSLDGLKFS 286
            ++L+       ++  +TL+ E ++  S  +E  H  + S N+ +   S L    D L   
Sbjct: 2272 VQLQ-------QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324

Query: 287  DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ 346
             ++ E   + +  + G      A +  ++K S  + E     S  L S L  E+N+ E Q
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQ-NSKFSYEQLETDLQASRELTSRLHEEINMKE-Q 2382

Query: 347  KLKQQLMQMEREKAGLLATL-QDTQKQLEHTRGSLSEQQE--------------KVTRLT 391
            K+   L   E      +A L Q   K+++     LS+++E              K  +L 
Sbjct: 2383 KIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442

Query: 392  ENLSALRRLQASKERQ--------TALDNEKDRDSHEDGDYYEVDINGPEILACKYHV-- 441
            E L  +++    ++ Q        ++L N++DR     GDY +++     I+  K  +  
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV---GDYQQLEERHLSIILEKDQLIQ 2499

Query: 442  -AVAEAGELREQLKALRSTHEAREAQHAE---EKGRYEAE-GQALTEKVS----LLEKAS 492
             A AE  +L+E+++ LRS  +   +++A+   E  +Y  +  Q +T K S    LLE   
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2559

Query: 493  RQDREL---LARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETP 549
            +Q++EL    A+LE++LK+  +   + + S +  Q+E    S+E+ +L   +     +  
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619

Query: 550  NRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSP 609
                     + +G  G      +   E   R S +         E           +   
Sbjct: 2620 -------ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK 2672

Query: 610  GSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDK 669
               +   L   ++E  ++++   I+R++    + A +R  EL+R  +  ++    V K+ 
Sbjct: 2673 VGEIEDKL---KKELKHLHHDAGIMRNE---TETAEERVAELARDLVEMEQKLLMVTKEN 2726

Query: 670  EALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYE---NEKAMVTETM 726
            + L  +I      +S+           L+ ++  A   L  LK KY+    E A + E  
Sbjct: 2727 KGLTAQIQSFGRSMSS-----------LQNSRDHANEELDELKRKYDASLKELAQLKEQG 2775

Query: 727  MKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAI 786
            +  R     L E A + +S         +  ++ L+++ +QL + +++   L+S L  + 
Sbjct: 2776 LLNRERDALLSETAFSMNSTE-------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY 2828

Query: 787  QQKLALTQRLELL--ELDH-----EQTRRG-----RAKAAPKTKPA 820
             Q  + ++ +  L  E DH     E+ R+      R+ A P T PA
Sbjct: 2829 NQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 185/848 (21%), Positives = 331/848 (39%), Gaps = 124/848 (14%)

Query: 23   RAEVKRLSHELAE-----TTREKIQAAEYG-LAVL-EEKHQLKLQFEELEVDYEAIRSEM 75
            R  ++RL+  LA+     + + K +    G LA+L EE+ +L  + +   ++ +++ S  
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569

Query: 76   EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
            E LK A      + +K+  + ES + S I ES   ++    K  ELQ E + L     N 
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE----KHKELQKEYEILLQSYENV 1625

Query: 136  QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
             +E ER+  V + +++  Q +    G+LR      K  E +L +   E+EE    ++K  
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELY---GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682

Query: 196  SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKN 255
               +Q  +E E    E  RL  E        ++ +     S   ++E LE +K E E   
Sbjct: 1683 KSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE--- 1736

Query: 256  SLRKELSHYMSINDSFY--TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLA---- 309
            +L K+    MS  DS       L   ++G        E     +   N  E G  +    
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796

Query: 310  -----KLPLDNK-TSTPKKEGLAPPSPSLVSDLLS--ELN--ISEIQKLKQQLMQMEREK 359
                  L +  + T +         +P++  D  S  E+N  + +I +LK+++  +E EK
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856

Query: 360  AG---LLATLQDTQK----QLEHTRGSLSEQQEKVTRLT-------ENLSALRRLQASKE 405
                    TL++ +     Q+    G L   QE+VT++        E LS + +L+ + E
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916

Query: 406  RQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ----LKALRSTHE 461
                   EKD D  E       ++NG     C+         EL E     LK   S  E
Sbjct: 1917 E------EKD-DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969

Query: 462  AREAQHAEEKGRYEAE-------------------------GQALTEK---VSLLEKASR 493
              + Q  +EK + E+E                          + L EK   V  L+K   
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029

Query: 494  QDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPN-RV 552
            + +E ++ LE+ +K +  V  E+Q  L + +       E LA    H      E  + +V
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITK-------ENLAQAVEHRKKAQAELASFKV 2082

Query: 553  MLDYYREGQGGAGRT-SPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGS 611
            +LD   + Q  A R  +   +   E +  +  +         +  R      +       
Sbjct: 2083 LLD---DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139

Query: 612  SLPSPLSDPRREPMNIYNLIAIIR-------DQIKHLQAAVDRTTELSRQRIASQELGPA 664
            ++   L   RRE +++   I  I+        +++ LQ  +D T     Q  A  +   +
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV---TQLAAFTKSMSS 2196

Query: 665  VDKDKEALMEEI----LKLKSLLSTKREQITTLR---TVLKANKQTAEVALANLK---SK 714
            +  D++ +++E      K    + +K E+I       +VLK   +   + +  LK   S+
Sbjct: 2197 LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256

Query: 715  YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
             E++K +      K + E++  ++   T         ++ +E        Q +LA  E E
Sbjct: 2257 LEHDKQIWES---KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313

Query: 775  KKTLNSLL 782
             K+L   L
Sbjct: 2314 LKSLKDQL 2321



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 174/848 (20%), Positives = 333/848 (39%), Gaps = 122/848 (14%)

Query: 37   TREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADG 96
            T + +Q  E   ++  E   LK Q   L    EA + ++E+  E       N+ +++  G
Sbjct: 911  TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970

Query: 97   ESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNV 156
            +  +E L  E    ++   ++  +LQ  L   + +L       E LA++  E K+     
Sbjct: 971  QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030

Query: 157  EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE 216
            E +RG + +D +  ++ E  +     E+E                      LK  I   E
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIY--------------------LKQTISEKE 1070

Query: 217  EETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL 276
             E +++   LE+ +  +E  +  +++  +TL+ +  Q + L+ E+S   +I     TS+ 
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130

Query: 277  HVSLDG---------------LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
              S DG                  S +  +P  + + L    E   L K   +  TS   
Sbjct: 1131 DAS-DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTS--- 1186

Query: 322  KEGLAPPSPSLVSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQL-EHTRG 378
            ++ +   +      L  EL     +  +L++Q  +  +E   +   L+  Q Q+ E   G
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246

Query: 379  SL--SEQQEKVTRLTENLSALRRLQASKERQTALDNE--KDRDSH-EDGDYYEVDINGPE 433
             L  ++QQE  +        L +       Q  L++    D  SH ED    +    G  
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ---GGTS 1303

Query: 434  ILACKYHVAVAEAGELREQLKALRSTHE----------------------------AREA 465
            +   K  +   EA ++  +LK   +T E                            + EA
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363

Query: 466  QHAEEKGRYEAEGQAL----TEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLS 521
            +   E  + + E   L     E +  L+    + ++L+++ E+++  +S    E + +L+
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423

Query: 522  VAQDELVTFSEELANLYHHVCMCNNETPNR-----VMLDYYREGQGGAGRTSPG----GR 572
              Q E++   + +  L+  + M   E   R     V L   ++     G  S       R
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483

Query: 573  TSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIA 632
                A   R   L     L  E   A  GT +      + + S +S   +E   +   +A
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLA-RGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542

Query: 633  IIRDQIKHLQAAVDRTTELSRQRIAS--QELGPAVD---KDKEALMEEILKLKSLLSTKR 687
            +++++   L   +DR+  L  Q ++S  + L  A++   +DKE L++EI   +SL S+K 
Sbjct: 1543 LLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDKEKLVKEI---ESLKSSKI 1598

Query: 688  EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR 747
             + T  +   K  ++  E+ L + ++   NE   +   +  +R E + L      +  LR
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYEN-VSNEAERIQHVVEAVRQEKQEL------YGKLR 1651

Query: 748  AMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTR 807
            +  A +         E ++QL  AE E + +   +R     K A +++ ++LEL+ E  R
Sbjct: 1652 STEANK--------KETEKQLQEAEQEMEEMKEKMR-----KFAKSKQQKILELEEENDR 1698

Query: 808  RGRAKAAP 815
              RA+  P
Sbjct: 1699 L-RAEVHP 1705



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 159/812 (19%), Positives = 328/812 (40%), Gaps = 72/812 (8%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +E Q +     +K+L  EL E  ++  +  E   A    K Q++ + +   +  +    E
Sbjct: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA----KQQIQRKLQAALISRKEALKE 1498

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTN 134
             + L+E    A    +++       E  +  ++  K+    R  L LQ E  +L   +  
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL-LQEERDKLITEMDR 1557

Query: 135  TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
            +  EN+ L+S  + LK   + +   + +L   +KE +  ++  + + +E +E++  LQK+
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKL---VKEIESLKSSKIAESTEWQEKHKELQKE 1614

Query: 195  VSVLRQN----QVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE 250
              +L Q+      E E ++H ++ + +E + L  +L      K+ +E+QL+EA + ++  
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674

Query: 251  REQKNSLRK-ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLA 309
            +E+     K +    + + +        V   G     D A+   +     N      L 
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAG-----DTAKECMETLLSSNASMKEELE 1729

Query: 310  KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDT 369
            ++ ++ +T + K + L         D LSE    E+Q LK Q+     ++A L AT +  
Sbjct: 1730 RVKMEYETLSKKFQSLMSE-----KDSLSE----EVQDLKHQIEGNVSKQANLEATEKHD 1780

Query: 370  QKQLEHTRGSLS-----EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
             +      G+ S     E+Q+ ++  T   +    + ++K    A+   KD  SH++ + 
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRP-TCSESVPSAKSANPAV--SKDFSSHDEINN 1837

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEK 484
            Y   I+       +    +A   E +++ K    T E  +     +    + E + L E+
Sbjct: 1838 YLQQID-------QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE 1890

Query: 485  VSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC-- 542
            V+ +   ++Q +E L+R    + K+ + A E +  L   ++ L+    EL     + C  
Sbjct: 1891 VTKMNLLNQQIQEELSR----VTKLKETAEEEKDDL---EERLMNQLAELNGSIGNYCQD 1943

Query: 543  MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
            + + +  N ++    +  +          +   + + +    +  + L   +  + + G 
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPG- 2002

Query: 603  GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVD-----RTTELSRQRIA 657
               + S    L   L + ++E   +       +++I  L+  V      +T       I 
Sbjct: 2003 ---NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059

Query: 658  SQELGPAVDKDKEALMEEILKLKSLL-STKREQITTLRTVLKANKQ---TAEVALANLKS 713
             + L  AV+  K+A   E+   K LL  T+ E    L   LK  K+     E   + +K 
Sbjct: 2060 KENLAQAVEHRKKA-QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118

Query: 714  KYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED 773
            K E+ +  + +       E K LKE       L A+   +     T + E+Q  L   + 
Sbjct: 2119 KDEDLERRLEQA------EEKHLKEKKNMQEKLDALRREKVHLEET-IGEIQVTLNKKDK 2171

Query: 774  EKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
            E + L   L   + Q  A T+ +  L+ D ++
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 108/543 (19%), Positives = 225/543 (41%), Gaps = 74/543 (13%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
            +S  S +EE  ++ +    +    E+K L + L++   E I   E     +++ +QL   
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMET 2444

Query: 61   FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
             + ++ +    +++++   ++      +  ++  D +  EE  +     K+Q       E
Sbjct: 2445 LKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAE 2504

Query: 121  ---LQTELKQLRNVLTNTQSENERL-ASVAQELKEINQNVEIQRGRLRDDI-------KE 169
               L+ E++ LR+ + +  SEN +L A + Q  +++NQ + I+  + +  +       KE
Sbjct: 2505 NNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564

Query: 170  YKFREARLLQDYSELEEENISLQKQVSVLRQNQ----VEFEGLKHEIKRL---------- 215
             + + A+L +   E EE N  L++  + L++ +     E E LK  I +L          
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624

Query: 216  -------------EEETEYLNSQLEDA-IRLKEISERQLEEALETLKTEREQKNSLRKEL 261
                         EEE   L++    +  R+ E+ E  +    E  K   E ++ L+KEL
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL 2684

Query: 262  SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
                         HLH     ++   + AE      A         L  +  +NK  T +
Sbjct: 2685 ------------KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQ 2732

Query: 322  KEGLAPPSPSL------VSDLLSEL------NISEIQKLKQQLMQMEREKAGLL------ 363
             +       SL       ++ L EL      ++ E+ +LK+Q + + RE+  LL      
Sbjct: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL-LNRERDALLSETAFS 2791

Query: 364  --ATLQDTQKQLEHTRGSLSEQQEKVTRLTENL-SALRRLQASKERQTALDNEKDRDSHE 420
              +T +++   LE     L  + E++  L+  L  +  ++Q+  +   +L NE+D   +E
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851

Query: 421  DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
               + + +  G +  A +   + AE   L++ + +L++  +    +    + +Y    Q 
Sbjct: 2852 LEKFRKSE-EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2910

Query: 481  LTE 483
            +TE
Sbjct: 2911 ITE 2913



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 130/637 (20%), Positives = 242/637 (37%), Gaps = 120/637 (18%)

Query: 5    SEEEEYARLVMEAQPEW--LRAEVKRLSHELAETTR--EKIQAAEYGLAVLEEKHQLKLQ 60
            S+ EE   L   +Q E   L +E+K L  +L + +   EK +  +  L  +  + +  +Q
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350

Query: 61   -----FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYV 115
                 +E+LE D +A R    +L E                  +E+ +I   + KE+   
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINM--------------KEQKIISLLSGKEEAIQ 2396

Query: 116  RKVLELQTELKQLRNVLTNTQSENERLASVAQE---------------LKEINQNVEIQR 160
              + EL+ +  +    L N  S+ E    V +E               LK I +    Q+
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456

Query: 161  GRLRDDIKEYKFRE---ARLLQDYSELEEENIS-LQKQVSVLRQNQVEFEGLKHEIKRLE 216
             +L   +K     +    R++ DY +LEE ++S + ++  ++++   E   LK EI+ L 
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR 2516

Query: 217  EETEYLNSQ--------------LEDAIRLKEISERQLEEALETLKTEREQKNS-LRKEL 261
               + LNS+              L   I +K+  ++QL E       E E K + L ++L
Sbjct: 2517 SHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576

Query: 262  SHYMSINDSFYTS---------HLHVSLDGLKFSDDAAEPNNDA--EALVNGFEHGGLAK 310
                  N+    S          L   ++ LK S         A  E    G  H  L  
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636

Query: 311  LPLDNKTSTPKKEGLAPPSPSLVSDLLSEL---------NISEIQ-KLKQQLMQMEREKA 360
                 +    +   L   S   +++L  EL          + EI+ KLK++L  +  +  
Sbjct: 2637 ----KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692

Query: 361  GLLATLQDTQKQLEHTRGSLSEQQEKVTRLT-ENLSALRRLQASKERQTALDNEKDRDSH 419
             +    +  ++++      L E ++K+  +T EN     ++Q+     ++L N +D  + 
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752

Query: 420  EDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQ 479
            E  +           L  KY  ++ E  +L+EQ                   G    E  
Sbjct: 2753 ELDE-----------LKRKYDASLKELAQLKEQ-------------------GLLNRERD 2782

Query: 480  A-LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
            A L+E    +          L +L ++L    +        L  + +++ +FS+ +A+L 
Sbjct: 2783 ALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842

Query: 539  HHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSP 575
            +      NE      L+ +R+ + G  R++    TSP
Sbjct: 2843 NERDHLWNE------LEKFRKSEEGKQRSAAQPSTSP 2873



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 173/875 (19%), Positives = 339/875 (38%), Gaps = 122/875 (13%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
            ++   E+E+  + + EA     R  + + + E     RE+++  +      ++ ++L+ Q
Sbjct: 1167 LALEKEKEQLQKKLQEALTS--RKAILKKAQEKERHLREELKQQK------DDYNRLQEQ 1218

Query: 61   FEELEVDYEAIRSEMEQLKEAFGQA------HTNHKKVAADGESREESLIQESASKEQYY 114
            F+E   + E I  ++ QL+    ++       T+ ++  +     EE L + +   EQ++
Sbjct: 1219 FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT---EQHH 1275

Query: 115  VRKVLELQ------------------TELKQLRNVLTNTQSENERL----ASVAQELKEI 152
             + VLE                    T + Q++  L   ++E   L    +S   EL + 
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335

Query: 153  NQNV-----EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ-KQVSVLRQNQVEFE 206
            ++ V     +I +  L  +  +    EA +  +  + + E+  LQ   +  LR+ Q + +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395

Query: 207  GLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMS 266
             L+  I + EE+  YL+ QL +            E AL  ++TE  ++  L K L   + 
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEK-----------EAALTKIQTEIIEQEDLIKALHTQLE 1444

Query: 267  INDSFY---TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE 323
            +    +      L V L  +K   +     + A+  +       L       K +   +E
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504

Query: 324  GLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK---AGLLATLQDTQKQL--EHTRG 378
             L     SL    +  L  S +  ++ Q+    +EK    G LA LQ+ + +L  E  R 
Sbjct: 1505 EL-----SLARGTIERLTKS-LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558

Query: 379  -----SLSEQQEKVTRLTENLS-----ALRRLQASKERQTALDNEKDRDSHEDGDYYEVD 428
                 SLS   E +    E L+      ++ +++ K  + A   E      E    YE+ 
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618

Query: 429  INGPEILACK----YHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEK 484
            +   E ++ +     HV  A   E +E    LRST EA + +  ++    E E + + EK
Sbjct: 1619 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST-EANKKETEKQLQEAEQEMEEMKEK 1677

Query: 485  VSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSL-----SVAQD-ELVTFSEEL 534
            +    K+ +Q      E   RL  E+    D A E   +L     S+ ++ E V    E 
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737

Query: 535  ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTS-------PGGRTSPEARGRRSPILLP 587
             +      M   ++ +  + D   + +G   + +          +T+    G +S     
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS----- 1792

Query: 588  KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDR 647
               +  E    D  +  + P+   S+PS  S         ++    I + ++ +    +R
Sbjct: 1793 ---IPGETEEQDSLSMSTRPTCSESVPSAKS-ANPAVSKDFSSHDEINNYLQQIDQLKER 1848

Query: 648  TTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVA 707
               L  ++  ++E    ++ +K  L+ +I      L   +E++T +  +L    Q     
Sbjct: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM-NLLNQQIQEELSR 1907

Query: 708  LANLKSKYENEKAMVTETMMKLRNELKAL-------KEDAATFSSLRAMFATRCDEYITQ 760
            +  LK   E EK  + E +M    EL            DA   + L         + +++
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE 1967

Query: 761  LDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
            L+E ++QL     EK  + S +R    +K+   Q+
Sbjct: 1968 LEEEKQQLV---KEKTKVESEIRKEYLEKIQGAQK 1999



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 154/833 (18%), Positives = 302/833 (36%), Gaps = 132/833 (15%)

Query: 13   LVMEAQPEWLRAEVKRLSHELAETTREKIQAA-EYGLAVLEEKHQLKLQFEELEVDYEAI 71
            L +E + + LRAEV    H   +T +E ++       ++ EE  ++K+++E L   ++++
Sbjct: 1690 LELEEENDRLRAEV----HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745

Query: 72   RSEMEQLKEAFG-------------------QAHTNHKKVAADGESREESLIQESASKEQ 112
             SE + L E                      + H N   V  +G        +E  S   
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805

Query: 113  YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
                   E     K     ++   S ++ + +  Q++ ++ + +          ++E K 
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA--------GLEEEKQ 1857

Query: 173  REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
            +     Q    LE E  +L  Q+S       E + L+ E+ ++    + +  +L    +L
Sbjct: 1858 KNKEFSQT---LENEKNTLLSQIST---KDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911

Query: 233  KEISERQLEEALETLKTEREQKNSLRKELSHY-MSINDSFYTSHLHVS-LDGLKFSDDAA 290
            KE +E + ++  E L  +  + N     + +Y   + D+   + L  S +  LK      
Sbjct: 1912 KETAEEEKDDLEERLMNQLAELNG---SIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968

Query: 291  EPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN--ISEIQK- 347
            E                + K  L+      K+ G    +  L  +LL E    + ++QK 
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL-QELLKEKQQEVKQLQKD 2027

Query: 348  ---LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE---------------------- 382
                ++++  +ER    L     ++QK LE T+ +L++                      
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087

Query: 383  QQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVA 442
            Q E    L +NL   + LQ++KE   +   +KD D     +  E                
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE-------------EKH 2134

Query: 443  VAEAGELREQLKALRSTHEAREAQHAEEK--------GRYEAEGQALTEKV--------- 485
            + E   ++E+L ALR     RE  H EE          + + E Q L E +         
Sbjct: 2135 LKEKKNMQEKLDALR-----REKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189

Query: 486  ---SLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
               S+      +DR ++   +K  +K SD     +  + + +D      ++L  +  H+ 
Sbjct: 2190 FTKSMSSLQDDRDR-VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM- 2247

Query: 543  MCNNETPNRVMLDYYREGQGGAGRTSP--GGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
                   N   L++ ++      +T      +     +G    +L               
Sbjct: 2248 --EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL--------SQLEETR 2297

Query: 601  GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQ 659
                SS +  + L S L   + +  ++ N +   ++Q  +L+  +  +  ++   + + +
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE 2357

Query: 660  ELGPAVDKDKE---ALMEEI----LKLKSLLSTKREQITTLRTVLKANKQTAEVALANLK 712
            +L   +   +E    L EEI     K+ SLLS K E I      L+         L NL 
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417

Query: 713  SKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQ 765
            S+ E E  ++ E   K  ++   L E   T          + D ++  +  +Q
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 126/586 (21%), Positives = 221/586 (37%), Gaps = 110/586 (18%)

Query: 7    EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-----LKLQF 61
            EEE A L  E++ E   +E +R   E+ E    K    EY    +  K Q     LK   
Sbjct: 1013 EEELANLKDESKKEIPLSETER--GEVEEDKENK----EYSEKCVTSKCQEIEIYLKQTI 1066

Query: 62   EELEVDYEAIRSEMEQ---LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV 118
             E EV+ + IR ++E+    +E F QA           ++ +  L+Q   S+ Q  ++K+
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQF-QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL 1125

Query: 119  LELQTELK---------------------------QLRNVLTNTQSENERLASVAQEL-- 149
            +   T+                             +L   +   + E E+L    QE   
Sbjct: 1126 ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185

Query: 150  --KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEG 207
              K I +  + +   LR+++K+ K    RL + + E  +EN ++  Q   LRQ Q+    
Sbjct: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ---LRQLQI---- 1238

Query: 208  LKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSI 267
                             Q+ ++I  K  S  Q E    T   E     +   E  H   +
Sbjct: 1239 -----------------QVRESIDGKLPSTDQQESCSSTPGLEEPLFKA--TEQHHTQPV 1279

Query: 268  NDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAP 327
             +S                 D    + DA AL  G     +A++    K    +K  L  
Sbjct: 1280 LES-------------NLCPDWPSHSEDASALQGG---TSVAQIKAQLKEIEAEKVEL-- 1321

Query: 328  PSPSLVSDLLSELNISEIQKLKQQLMQMERE--KAGL-LATLQDTQKQLEHTRGSLSEQQ 384
                   +L      SE+ K  +++ Q++ +  K GL + +L+    + E    SL ++ 
Sbjct: 1322 -------ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374

Query: 385  EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
            E        L  LR LQ   +    L ++K+    ED  Y    ++  E    K    + 
Sbjct: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKE----EDVSYLSGQLSEKEAALTKIQTEII 1430

Query: 445  EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
            E  +L   +KAL +  E +  +H E   + + E   + +K   + + SR  +++  +L+ 
Sbjct: 1431 EQEDL---IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487

Query: 505  ELKKVSDVAGET---QGSLSVAQDELVTFSEELANLYHHVCMCNNE 547
             L    +   E    Q  LS+A+  +   ++ LA++   V   N E
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 109/558 (19%), Positives = 220/558 (39%), Gaps = 84/558 (15%)

Query: 4   PSEEEEYARLVMEAQPEWLRAEVKRLSHEL-----------AETTREKIQAAEYGLAVLE 52
           P  EE+ ++    +  E +  E++++ H+L           A+ T+ + +        +E
Sbjct: 126 PQSEEQLSKHDKSSTEEEM--EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183

Query: 53  EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
           E   +K Q +E E     +++++ Q      QA    ++V  + ++R E+ ++    +  
Sbjct: 184 EFVMMKQQLQEKEEFISTLQAQLSQT-----QAEQAAQQVVREKDARFETQVRLHEDELL 238

Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
             V +  +++TE++Q   VL     E+E      + L    Q V++              
Sbjct: 239 QLVTQA-DVETEMQQKLRVLQRKLEEHE------ESLVGRAQVVDL-------------- 277

Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
               L Q+ +  E+ N  L +Q   L+Q + E   L++ ++   EE++ L  ++E  +  
Sbjct: 278 ----LQQELTAAEQRNQILSQQ---LQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330

Query: 233 KEISERQLEEALETLKTEREQKNSLRKEL-SHYMSINDSF------YTSH---------- 275
           +++S   L+E +  L  + EQ    + EL S Y ++           TSH          
Sbjct: 331 RKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390

Query: 276 LHVSLDGLK---------FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLA 326
           L  + D LK          ++ A +     + L +  +          N+    + E  +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450

Query: 327 PPS-PSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
             S P + ++    +    I  L+++++++E EK  LL     +  +LE  +    +   
Sbjct: 451 QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL----SSIELEELKAENEKLSS 506

Query: 386 KVTRL-TENLSALRRLQASKERQTALDNEKDRDSHEDG-DYYEVDINGP----EILACKY 439
           ++T L  +N +     + S+     + N++   + E G D  E   +       +L  + 
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566

Query: 440 HVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELL 499
             A  E   L+ QL+  R+     E    +E  + E EG A  +    LE    QD  L+
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTG-QDFPLM 625

Query: 500 ARLEKELKKVSDVAGETQ 517
              E  L  V      T+
Sbjct: 626 PNEESSLPAVEKEQASTE 643



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 88/395 (22%), Positives = 167/395 (42%), Gaps = 58/395 (14%)

Query: 25   EVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQ 84
            ++  LS +L E +  ++Q+    +A L+ +       + L  + E  R   E  + +  Q
Sbjct: 2816 QLLHLSSQL-EDSYNQVQSFSKAMASLQNER------DHLWNELEKFRKSEEGKQRSAAQ 2868

Query: 85   AHTNH------KKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
              T+       KK  +  ++  + L++E  + +Q Y++   E+ TEL  L+  L   Q +
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDK 2927

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY----SELEEENISLQKQ 194
             +    + +EL++ N + + +  +LR +   ++  E R+ + Y    S+ +++   LQ  
Sbjct: 2928 TKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNL 2987

Query: 195  VSVLRQNQVEFEGLKHEIKR---------------LEEETEYLNSQLEDAIRLKEISERQ 239
            +  LR +  + + LK + +R               L  ETE L +QL D+++     E +
Sbjct: 2988 IRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047

Query: 240  LEEALETLKTEREQKNSLRKEL---SHYMSINDSFYTSHL-HVSLDGLKFSDDAAEPNND 295
            +++         E+KN+L  +L   S  +  N   Y   L H ++   +  +  A P N 
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107

Query: 296  AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
              A     E  G+      ++ S P  E L  P  S           SE Q   QQL   
Sbjct: 3108 DVAPGAPQEKNGV------HRKSDP--EELREPQQS----------FSEAQ---QQLCNT 3146

Query: 356  EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
             +E   L   L++ + Q      +LS  +E++ RL
Sbjct: 3147 RQEVNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 168/840 (20%), Positives = 319/840 (37%), Gaps = 129/840 (15%)

Query: 37   TREKIQAAEYGLAVLE-EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAAD 95
            T E I + +  +  LE EK  L L   ELE     +++E E+L          ++   AD
Sbjct: 466  TEENIASLQKRVVELENEKGALLLSSIELE----ELKAENEKLSSQITLLEAQNRTGEAD 521

Query: 96   GESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQ-ELKEINQ 154
             E  E S++ + A+K            +  +  ++VL NT S+  +  SV   E+KE  +
Sbjct: 522  REVSEISIV-DIANKRS---------SSAEESGQDVLENTFSQKHKELSVLLLEMKEAQE 571

Query: 155  NVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE--- 211
             +   + +L+    E    E    ++  ++E E I+  K    L     +F  + +E   
Sbjct: 572  EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631

Query: 212  ---IKRLEEETEYLNSQLEDAIRL----------KEISERQL----------EEALETLK 248
               +++ +  TE+  S+  + I L          K+  ++ L          ++ LE LK
Sbjct: 632  LPAVEKEQASTEH-QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK 690

Query: 249  TE---------------REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN 293
            ++                +  +   KE+S+   + + F  +  + S      S++  +  
Sbjct: 691  SQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLL 750

Query: 294  NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE----LNISEIQK-L 348
            +  + L    E     K    N     ++  L   S +   +LL+E    L+I    K +
Sbjct: 751  SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810

Query: 349  KQQLMQMEREKAGLLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS 403
            K +++Q E +   L  + Q T     Q QL++    + E  E+V  ++  +  L +  + 
Sbjct: 811  KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870

Query: 404  KERQ-TALDN---EKDRD--------SHEDGDYYEVDINGPEILAC----KYHVAVAEAG 447
            KE + T +D    EK RD          +D    E+  +  E +      K+ + V E  
Sbjct: 871  KELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV-EIK 929

Query: 448  ELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELK 507
             L+EQL  L    EA++ Q  E+          L +    +  A +  +E L      LK
Sbjct: 930  TLKEQLNLLSRAEEAKKEQVEED----NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985

Query: 508  KVSDVAGETQGSLSVAQDELV----TFSEELANLYHHVCMCNNETPNRVMLDYYREGQGG 563
            K ++       +  + + EL+       EELANL        +E+   + L     G+  
Sbjct: 986  KENEQRKRKLQAALINRKELLQRVSRLEEELANL-------KDESKKEIPLSETERGEVE 1038

Query: 564  AGRTSPG-GRTSPEARGRRSPILLPKGLLAPEAG----RADGGTGDSSPSPGSSLPSPLS 618
              + +         ++ +   I L + +   E      R D     ++     +L   ++
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098

Query: 619  DPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILK 678
               ++  N          QI  LQA +     + ++ I S     A D D  AL++E + 
Sbjct: 1099 QTLQDKTN----------QIDLLQAEISENQAIIQKLITSNT--DASDGDSVALVKETVV 1146

Query: 679  LKSLLSTKREQ-ITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALK 737
            +    +   E     L   + A ++  E     L+    + KA++ +   K R+  + LK
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206

Query: 738  EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE 797
            +    ++ L+  F           DE  ++     D+ + L   +R +I  KL  T + E
Sbjct: 1207 QQKDDYNRLQEQF-----------DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 83/439 (18%), Positives = 168/439 (38%), Gaps = 64/439 (14%)

Query: 186 EENISLQKQVSVLRQNQVEFEGLKHE-IKRLEEETEYLNSQLEDAIRLKEISERQLEEAL 244
           ++N+       + +++ +EF     E ++      E L  +L+D IR K++  +Q +EAL
Sbjct: 23  DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82

Query: 245 ETLKTEREQK------------NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEP 292
           +  +   + K             SL K +    +   +   +         K    + E 
Sbjct: 83  QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142

Query: 293 NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKL 348
             + E + +  +        L  + +  + E  A  S  +   ++ +  + E    I  L
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202

Query: 349 KQQLMQMEREKAG-----------------------LLATLQDT----QKQLEHTRGSLS 381
           + QL Q + E+A                         L T  D     Q++L   +  L 
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262

Query: 382 EQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDG---DYYEVDINGPEILAC 437
           E +E +    + +  L++ L A+++R   L  +  +   E     +  E +    +IL  
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322

Query: 438 KYHVAVAEA----GELREQLKALRSTHEAREAQHAEEKGRYEAEGQ----ALTEKVSLLE 489
           K  + VAE       L+E++  L    E      AE + RY A  Q     + EK S + 
Sbjct: 323 KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHIL 382

Query: 490 KASRQDRELLARLE-------KELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
              +  +EL +  +       K L+  ++ A ++  ++   +D+L   S+E++   + + 
Sbjct: 383 SLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442

Query: 543 MCNNETPNRVML-DYYREG 560
           +  +ET ++    D Y EG
Sbjct: 443 LQQHETASQTSFPDVYNEG 461



 Score = 30.4 bits (67), Expect = 7.0
 Identities = 33/166 (19%), Positives = 71/166 (42%), Gaps = 8/166 (4%)

Query: 634 IRDQIKHLQAAVDRTTELSRQR-IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
           +++++ + +  V    ++ RQ+ +  Q+   A+ ++++A   +I KLK     K   +  
Sbjct: 50  VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 109

Query: 693 LRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMF-- 750
               +KA   T        + +        TE  M++      L+E     S+L+A    
Sbjct: 110 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169

Query: 751 --ATRCDEYITQLDE---MQRQLAAAEDEKKTLNSLLRMAIQQKLA 791
             A +  +  T+++E   M++QL   E+   TL + L     ++ A
Sbjct: 170 AQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score =  102 bits (255), Expect = 1e-21
 Identities = 196/836 (23%), Positives = 332/836 (39%), Gaps = 127/836 (15%)

Query: 7    EEEYARL------VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
            EE+  RL       M+A  +  R EV+RL       +REK   A       ++  +L+ +
Sbjct: 567  EEQLQRLRDKTDGAMQAHEDAQR-EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE 625

Query: 61   FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
             E+L+   E +R + ++L+E    A  +  +V  + E R    +++   K     ++++E
Sbjct: 626  REKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE-RSHRQLEQLEGKRSVLAKELVE 684

Query: 121  LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR-------DDIKEYKFR 173
            ++  L +        Q+E   +A    + +     +E+   +LR       D + +    
Sbjct: 685  VREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSAL 744

Query: 174  EARLLQD-------YSELEEENISLQKQVSVLRQNQVEFEG--LKHEIKRLEE---ETEY 221
               L QD        ++LEEE  +LQ      RQ Q E E    + E +RLEE   E E 
Sbjct: 745  NESLAQDKLDLNRLVAQLEEEKSALQG-----RQRQAEQEATVAREEQERLEELRLEQEV 799

Query: 222  LNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
                LE ++R+ E ++  LE+ L TL+ ER Q      +LS  +S  +         +  
Sbjct: 800  ARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859

Query: 282  GLKFSDDAAEPNNDAEALVNGFEHGGLA----KLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
             ++  + AA    + EAL    EH GLA        + +T + +   L     +L   L 
Sbjct: 860  QVEALERAA---REKEALAK--EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914

Query: 338  SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL 397
                  ++ +L+ +  Q+E E   LL   +    +L   R  +   QEK + L + L A 
Sbjct: 915  EVQR--QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS-LDKELMAQ 971

Query: 398  RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
            + +QA +E Q +L   + R +HE+ D   +           +    AE  +L+ QL    
Sbjct: 972  KLVQAEREAQASL--REQRAAHEE-DLQRLQ----REKEAAWRELEAERAQLQSQL---- 1020

Query: 458  STHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ 517
                  + +  E   R EAE + L+E+++ L++  R +  LLA  EK            Q
Sbjct: 1021 ------QREQEELLARLEAEKEELSEEIAALQQ-ERDEGLLLAESEK------------Q 1061

Query: 518  GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEA 577
             +LS+ + E    SE+L    H +   + E   +      R+ Q    R++    TS E 
Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ---DRSTVNALTS-EL 1117

Query: 578  RGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQ 637
            R  R+         A E  R      D      S L        RE          +R Q
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL--------REAEE-------LRTQ 1162

Query: 638  IKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVL 697
            ++ L+ A D    L R+ + +Q       + +E   +E  +L+  L    ++   LR   
Sbjct: 1163 LRLLEDARD---GLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALR--- 1216

Query: 698  KANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEY 757
            ++N++     L +   K E+E+       +KL NE K  ++  A     R        E 
Sbjct: 1217 RSNEE-----LRSAVKKAESER-----ISLKLANEDK--EQKLALLEEARTAVGKEAGEL 1264

Query: 758  ITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
             T L E++R    A  E + L   ++M                LD E TR GR  A
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKM----------------LDSENTRLGRELA 1304



 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 178/813 (21%), Positives = 316/813 (38%), Gaps = 130/813 (15%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQL---KLQFEELEVDYEAIRSEME 76
            E +  ++ +   E   + RE+  A E  L  L+ + +    +L+ E  ++  +  R + E
Sbjct: 967  ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEE 1026

Query: 77   QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRNVLT 133
             L     +     +++AA  + R+E L+   + K+Q    K  E   L  +L   R+ L 
Sbjct: 1027 LLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLA 1086

Query: 134  NTQSENERLASVAQELKEINQN-VEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
                E ER    AQ  +E +++ V      LRD   + +   A   Q+   L+E+   L 
Sbjct: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146

Query: 193  KQV-SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
            KQ  S LR    E E L+ +++ LE+  + L  +L +A       +R+L E+ E  + +R
Sbjct: 1147 KQRDSCLR----EAEELRTQLRLLEDARDGLRRELLEA-------QRKLRESQEGREVQR 1195

Query: 252  EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKL 311
            ++   LR+ L       ++   S+     + L+ +   AE    +  L N  +   LA L
Sbjct: 1196 QEAGELRRSLGEGAKEREALRRSN-----EELRSAVKKAESERISLKLANEDKEQKLALL 1250

Query: 312  PLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQK 371
              + +T+  K+ G                      +L+  L ++ER +        + ++
Sbjct: 1251 E-EARTAVGKEAG----------------------ELRTGLQEVERSRL-------EARR 1280

Query: 372  QLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDING 431
            +L+  R  +     + TRL   L+ L       + + AL    +++S             
Sbjct: 1281 ELQELRRQMKMLDSENTRLGRELAEL-------QGRLALGERAEKESRR----------- 1322

Query: 432  PEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKA 491
             E L  +  +   EA      L+ +R   +  + +  E++G +    + L   +      
Sbjct: 1323 -ETLGLRQRLLKGEAS-----LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGT 1376

Query: 492  SRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR 551
             +Q  +    LE +L+     A E    LS A+        ELA +   V     E    
Sbjct: 1377 EKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV--EVQRRAAEAQLG 1434

Query: 552  VMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL-LPKGLLAPEAGRADGGTGDSSPSPG 610
             +    R G G     SP  R  P +  R +P     +GL +P       G+   SP P 
Sbjct: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494

Query: 611  SSLPSPLSDP-----------------RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSR 653
            +S  SP  DP                 +RE   +    + +  Q+  ++A  D  T  +R
Sbjct: 1495 TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRAR 1554

Query: 654  QR----IASQELGPAVDKDKEALMEEI-LKLKSLLSTKREQITTLRTV--LKANKQTAEV 706
            Q       S+E   +VD     +  E+ L+ +S+  ++RE+  TL  V  L+ + Q  E 
Sbjct: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614

Query: 707  ALANLKSKYENEKAMVTETMMKLRNELKALKE--DAATFSSLRAMFATRCDEYITQ---- 760
             L   + K    KA  T    KL  + + LKE  DA+   +++     R  E   Q    
Sbjct: 1615 ELRASQEKISKMKANET----KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL 1670

Query: 761  ---------------LDEMQRQLAAAEDEKKTL 778
                           +D +QRQ+A +E +  TL
Sbjct: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTL 1703



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 177/754 (23%), Positives = 300/754 (39%), Gaps = 111/754 (14%)

Query: 94   ADGESREESLIQESASKEQYYVRKVL----ELQTELKQLRNVLTNTQSENERLASVAQEL 149
            A  +S   +LI  +  K Q  V+ +       Q  L  LR  L++++SE   L    Q L
Sbjct: 514  ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL 573

Query: 150  KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLK 209
            ++            + +++  +     L ++ S L       Q+Q   LRQ + + +  +
Sbjct: 574  RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQ 633

Query: 210  HEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSIND 269
             E++R   + + L  + EDA++      R+LE +   L+    +++ L KEL   + + +
Sbjct: 634  EELRR---QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL---VEVRE 687

Query: 270  SFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPS 329
            +   S   +  D L+     AE    AEAL       G  +L L + T    +E     S
Sbjct: 688  AL--SRATLQRDMLQ-----AEKAEVAEALTKA--EAGRVELEL-SMTKLRAEEASLQDS 737

Query: 330  PSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTR 389
             S +S L   L   ++  L + + Q+E EK    + LQ  Q+Q E       E+QE++  
Sbjct: 738  LSKLSALNESLAQDKLD-LNRLVAQLEEEK----SALQGRQRQAEQEATVAREEQERLEE 792

Query: 390  LTENLSALRR-----LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
            L       R+     L+ +++ Q AL+ +     H                         
Sbjct: 793  LRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH------------------------- 827

Query: 445  EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
            E  +L+EQL  L      RE +   E+ R EA+ Q     V  LE+A+R ++E LA+   
Sbjct: 828  ERSQLQEQLAQLSRQLSGREQE--LEQARREAQRQ-----VEALERAAR-EKEALAKEHA 879

Query: 505  ELKKVSDVAGETQG-SLSVAQDELVTFSEEL-ANLYHHVCMCNNETPNRVMLDYYREGQG 562
             L  V  VA E +G +LS     L    E L  +L+            R  L+   +   
Sbjct: 880  GL-AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938

Query: 563  GAGRTSPGGRTSPEARGRRSPIL-------LPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
             A  T  G     E  G R  I+       L K L+A +  +A+     S     ++   
Sbjct: 939  LAKETLTG-----ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993

Query: 616  PLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEE 675
             L   +RE    +  +   R Q++         ++L R++   +EL   ++ +KE L EE
Sbjct: 994  DLQRLQREKEAAWRELEAERAQLQ---------SQLQREQ---EELLARLEAEKEELSEE 1041

Query: 676  ILKLKS-------LLSTKREQITTL----RTVLKANKQTAEVALANLKSKYENEKAMVTE 724
            I  L+        L  ++++Q  +L    +T L         +LA +  + E +K     
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQS 1101

Query: 725  TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRM 784
               + R+ + AL       S LR + A R +       E++R    A D  K  +S LR 
Sbjct: 1102 RQEQDRSTVNALT------SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155

Query: 785  AIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
            A +    L  +L LLE   +  RR   +A  K +
Sbjct: 1156 AEE----LRTQLRLLEDARDGLRRELLEAQRKLR 1185



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 177/817 (21%), Positives = 298/817 (36%), Gaps = 128/817 (15%)

Query: 29   LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTN 88
            L  EL E  R+  ++ E      +E  +L+    E   + EA+R   E+L+ A  +A + 
Sbjct: 1173 LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE 1232

Query: 89   HKKVAADGESREESLI-----QESASKE--------QYYVRKVLELQTELKQLRNVLTNT 135
               +    E +E+ L      + +  KE        Q   R  LE + EL++LR  +   
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292

Query: 136  QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
             SEN RL    +EL E+   + +     ++  +E      RLL+  + LE     LQ   
Sbjct: 1293 DSENTRLG---RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ 1349

Query: 196  SVLRQNQVEFEGLKHEIK-RLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK 254
              L++ + EF   +  +   LEE       QL+ A        R LE  LE  + E    
Sbjct: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA--------RGLELKLEAARAEAA-- 1399

Query: 255  NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--EALVNGFEHGGLAKLP 312
                 EL   +S  +      L   L  ++    AAE        AL  G    GL + P
Sbjct: 1400 -----ELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGL---GLGRAP 1450

Query: 313  LDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQ 372
                   P       P+      L S   +       +     +    G   +       
Sbjct: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTL-------ECSPGSQPPSPGPATSPASPDLD 1503

Query: 373  LEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGP 432
             E  RG+L E  +++         LR   ++  RQ A + E +RDS              
Sbjct: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLA-EMEAERDSATSR---------- 1552

Query: 433  EILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKAS 492
               A +   AVAE+ E R  +    S  +A  A   E   R E E +A  ++V+ LE++ 
Sbjct: 1553 ---ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609

Query: 493  RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV 552
            +     L   ++++ K+     + +G     + E++  SE                   V
Sbjct: 1610 QATESELRASQEKISKMKANETKLEGDKRRLK-EVLDASES----------------RTV 1652

Query: 553  MLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSS 612
             L+  R    G  + S  G +  EA+ +          L            DS    G+ 
Sbjct: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQA---------LQDRVDSLQRQVADSEVKAGT- 1702

Query: 613  LPSPLSDPRREPMNIYNLIAIIRDQIKHL-QAAVDRTTELSRQRIASQELGPAV---DKD 668
            L   +         +      +RD+++ L +A    +  L+  R  +  L  A+   + D
Sbjct: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762

Query: 669  KEALMEEILKLKSLLSTKR-------EQITTLR---TVLKANKQTAEVALANLKS---KY 715
            ++ L E +   +  LS  R       EQ+ TLR     L+  +  AE  L  L+    + 
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822

Query: 716  ENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK 775
            +  +A    T+ KL++E + L+E                     +L  +QR LA  E EK
Sbjct: 1823 QEGEAAALNTVQKLQDERRLLQE---------------------RLGSLQRALAQLEAEK 1861

Query: 776  KTLNSLLRMAIQQKLALTQRLELLELD----HEQTRR 808
            + +        + ++AL + L+ +E +    HE T R
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 174/819 (21%), Positives = 320/819 (39%), Gaps = 114/819 (13%)

Query: 13  LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-LKLQFEELEVDYEA- 70
           L ++ + + L+ E+ R+   LA++  E+ + A    AV E   Q L+L+  ELE      
Sbjct: 77  LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136

Query: 71  -IRSEMEQLKEAFGQAHTNHKKVAA--DGESREESLIQESASKEQYYVRKVLELQTELKQ 127
            +R  +E  ++   +  +  +K+ A  +G+ R+  L+Q    K   Y ++  EL+ +L +
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196

Query: 128 LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
               L              Q L++   + +++   +R  ++E + R A L Q  + L E+
Sbjct: 197 RSGELEQ------------QRLRDTEHSQDLESALIR--LEEEQQRSASLAQVNAMLREQ 242

Query: 188 NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET- 246
                     L Q     + L  +I+++  +      +LE     +E + R+ EE+    
Sbjct: 243 ----------LDQAGSANQALSEDIRKVTNDWTRCRKELEH----REAAWRREEESFNAY 288

Query: 247 LKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
              E  +   L +++  +  +        +    D L+   + A  +   +    G   G
Sbjct: 289 FSNEHSRLLLLWRQVVGFRRLVSEV---KMFTERDLLQLGGELARTSRAVQEAGLGLSTG 345

Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK--LKQQLMQMEREKAGLLA 364
              +L      +  +K+ L      L + L  +L    +++  L QQ MQ + +KA L A
Sbjct: 346 --LRLAESRAEAALEKQAL------LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA 397

Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHED-GD 423
            + +    ++       E+ +    LTE L AL  L+   + Q AL+ E      +   D
Sbjct: 398 RVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL--QEQAALETEDGEGLQQTLRD 455

Query: 424 YYEVDINGPEI---LACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
             +  ++  E    L+     A A  G LR  L   R+    R +     +        A
Sbjct: 456 LAQAVLSDSESGVQLSGSERTADASNGSLR-GLSGQRTPSPPRRSSPGRGRSPRRGPSPA 514

Query: 481 LTEKVSL------LEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
            ++  +L      L K   Q +++  R E       D+ G  +  LS ++ E     E+L
Sbjct: 515 CSDSSTLALIHSALHKRQLQVQDMRGRYEAS----QDLLGTLRKQLSDSESERRALEEQL 570

Query: 535 ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPE 594
             L             R   D   +    A R     R++ E   R    L     +A +
Sbjct: 571 QRL-------------RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQ 617

Query: 595 AGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA-AVDRTTELSR 653
                    +        L +   + RR+           RD+++  Q  AV     + R
Sbjct: 618 -------QAEELRQEREKLQAAQEELRRQ-----------RDRLEEEQEDAVQDGARVRR 659

Query: 654 QRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKS 713
           +   S      ++  +  L +E+++++  LS    + T  R +L+A K  AEVA A   +
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALS----RATLQRDMLQAEK--AEVAEA--LT 711

Query: 714 KYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED 773
           K E  +  +  +M KLR E  +L++  +  S+L    A        +LD + R +A  E+
Sbjct: 712 KAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ------DKLD-LNRLVAQLEE 764

Query: 774 EKKTLNSLLRMAIQQKLAL---TQRLELLELDHEQTRRG 809
           EK  L    R A Q+        +RLE L L+ E  R+G
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG 803



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 112/534 (20%), Positives = 209/534 (39%), Gaps = 62/534 (11%)

Query: 16   EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
            +  PE +R  ++    EL    RE+ +       +  +   L  Q  E+E + ++  S  
Sbjct: 1501 DLDPEAVRGALREFLQELRSAQRERDE-------LRTQTSALNRQLAEMEAERDSATSRA 1553

Query: 76   EQLKEAFGQAHTNHKKVAA--DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
             QL++A  ++    + V     G   E +L +ES  + +   R  L+   ++  L   L 
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLD---QVATLERSLQ 1610

Query: 134  NTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQK 193
             T+SE         ++K     +E  + RL++ +   + R  +L      LE E   LQ+
Sbjct: 1611 ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE---LQR 1667

Query: 194  QVSVLRQNQVEFEGLKHEIKRLEEE---TEYLNSQLEDAIRLKEISERQLEEALETLKTE 250
                L   + + + L+  +  L+ +   +E     L+  +     +  ++EE+   L   
Sbjct: 1668 SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL--- 1724

Query: 251  REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
            R++   L + L+   +  +S    +LH+         D        +A            
Sbjct: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784

Query: 311  LPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE--IQKLKQQLMQMEREKAGLLAT--- 365
              L  +  T + E         V+DL  +   +E  +Q+L++ L Q +  +A  L T   
Sbjct: 1785 SSLGEQVQTLRGE---------VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK 1835

Query: 366  LQDTQKQLEHTRGSLS-----------EQQEKVTRLTENLSALRRLQASKERQTALDNEK 414
            LQD ++ L+   GSL            E +    RL ++  ALRR     ER+    +E 
Sbjct: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED 1895

Query: 415  DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR----EAQHAEE 470
                  +    +  + G E+   +   A  +  +L  Q+  L  +H       +AQ  + 
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAE---AQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952

Query: 471  KGRYEAE----GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSL 520
            + + E E     QA TE+   LE   R  R+ +  LE++   VS + G+ Q  L
Sbjct: 1953 ELQQEVERLRSAQAQTERT--LEARERAHRQRVRGLEEQ---VSTLKGQLQQEL 2001



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 94/446 (21%), Positives = 170/446 (38%), Gaps = 57/446 (12%)

Query: 2    SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETT--REKIQAAEYGLAVLEEKHQLKL 59
            SA S   +  + V E++ E  R+   RLS   AE     E ++ +E       E+     
Sbjct: 1548 SATSRARQLQKAVAESE-EARRSVDGRLSGVQAELALQEESVRRSE------RERRATLD 1600

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL-IQESASKEQYYVRKV 118
            Q   LE   +A  SE+   +E   +   N  K+  D    +E L   ES + +    R+ 
Sbjct: 1601 QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660

Query: 119  LE-------------------LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQ 159
            LE                   LQ  +  L+  + +++ +   L    + L      VE  
Sbjct: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720

Query: 160  RGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQN-QVEFEGL---------- 208
             G LRD ++      A+     +   ++N+ LQK ++    + QV  E L          
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780

Query: 209  KHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK----NSLRKELSHY 264
            + +   L E+ + L  ++ D    +  +E QL++  E L+  +E +    N+++K     
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840

Query: 265  MSIND---SFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
              + +   S   +   +  +  +    A     D  AL        L K+  +   S   
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVAL-----RRTLDKVEREKLRSHED 1895

Query: 322  KEGLAPPSPSLVSDLL-SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
               L+     L   L  +EL ++E Q+   Q+ Q+E +   L  +    Q +++  +  L
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952

Query: 381  SEQQEKVTRLTENLSALRRLQASKER 406
              QQE V RL    +   R   ++ER
Sbjct: 1953 ELQQE-VERLRSAQAQTERTLEARER 1977


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)

Query: 35   ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
            + T+E+ Q AE  L  LE+KH       +L  +   ++ +++   E + +A     ++AA
Sbjct: 862  QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915

Query: 95   DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
              +  EE L +  A  E+   R   +LQ E K++   + + + + E   +  Q+L+    
Sbjct: 916  KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 155  NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
              E +  +L D+I         L+ D   ++L +E   L++++S L  N  E E     +
Sbjct: 975  TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 213  KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
             +L+ + E + S+LE  ++ +E S ++LE+    L+ +     EQ   L+ +++  + + 
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1084

Query: 269  DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
             +     L  +L   +  D+ A+ NN      + E  ++  +    ++    NK    K+
Sbjct: 1085 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 323  EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
            + L     +L ++L   L+ +  Q   Q+L     ++  +L  A  ++T+      +   
Sbjct: 1143 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 381  SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
             +  + V  LTE L   +R +A+      LD  K     E+ D                 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1236

Query: 441  VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
                 AGELR   +A       +E +H  +K + EA+ Q L  K S  E+A  +  + + 
Sbjct: 1237 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1283

Query: 501  RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
            +L+ E++ V+ +  E +G       ++ + S +L +      +   ET  ++ +   +  
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1339

Query: 561  QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
            Q    R S   +   E   +++   L + +                    S+L   LSD 
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1376

Query: 621  RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
            +++  +  + +  + +  K  Q  ++  T+   ++ A+ +    ++K K  L +E+  L 
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1433

Query: 681  SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
              L  +R+ ++ L +   K ++  AE    N+ SKY +E+                 A  
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 723  TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
             E  ++ + E       LKA  ED  +               +    T+ +E  TQL+E+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 765  QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
            + +L A ED K               + L +      +++  L ++L   E + E  R+ 
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611

Query: 810  RAKAAPKTK 818
            RA AA   K
Sbjct: 1612 RALAAAAKK 1620



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 185/868 (21%), Positives = 341/868 (39%), Gaps = 123/868 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
            + E  AR   E Q   L  E++ L  EL +T     T+++++A  E  + VL++    + 
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            +  E +V  + +R +  Q  E   +     K+  A+ +  +++L +E+A           
Sbjct: 1188 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1234

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            +L  EL+ L       + + ++L +  QEL+    + E  R  L D + +          
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1284

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
                       LQ +V  +     E EG   +  +L ++   L+SQL+D   L +   RQ
Sbjct: 1285 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 240  LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
                   L+   E++NSL+ +L   M    +      H+S   ++ S D+ +   D  + 
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1386

Query: 300  VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
            V   E G          L +   +   +  K E         + DL+ +L+     +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K +++  Q+  E+  + +   D + + E      +E +EK T+    LS  R L+ + E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1497

Query: 406  RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
             +  L+          +D  S +D    + +E++      L  +      +  EL ++L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1556

Query: 455  ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
            A        E      KG++E + QA  E+      +  RQ  E    LE E K+ +  A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616

Query: 514  GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
               +        L +  D  +   EE       +           M D+ RE +      
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1668

Query: 568  SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
                 T+ E    A+   + ++ L + L A E  R  AD    + +    SSL   + L 
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 619  D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
            D  RR    I  L   + ++  +++A  DR  + ++Q    S EL        K++ A  
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788

Query: 674  EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
            +   + K L S   E    +++  K+     E  +A L+ + E E          L+ + 
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 734  KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
            K LKE        R M   +  + ++   ++ +++RQL  AE+E + +N     A ++KL
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1903

Query: 791  ALTQRLELLELDHEQTRRGRAKAAPKTK 818
                + EL E        GR   A K+K
Sbjct: 1904 ----QRELDEATESNEAMGREVNALKSK 1927



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +E +   L  E   L  +L   T    +A E  + +  +K +L+    E+E       + 
Sbjct: 878  LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 930

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
            +E+ ++   Q     KK+A      EE L +E A++++  + KV       +L+ E+   
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990

Query: 126  ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
                           +++ ++ TN   E E+   L  +  + + +   +E++  +     
Sbjct: 991  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050

Query: 168  KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
            +E +  + +L  D S+  E+   LQ Q++ L+ Q   + E L+  + RL++E    N+ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 227  -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
                               E A R K E  +R L E LE LKTE E        +  LR 
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 260  ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
            +    +++        L  +LD    S +A       +     E L    E    AK  L
Sbjct: 1171 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 314  DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
            D    T +KE          +DL  EL +                +++Q+L+ +    ER
Sbjct: 1223 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 358  EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
             +A L   +   Q ++E   G L+E + K  +L +++++L  +LQ ++E      RQ   
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 411  DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
             + K R   E+     D  + ++   + L         +  + +++L+   ST EA E  
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1391

Query: 467  HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
              E K R++ E + LT++    EKA+  D     +LEK           T+  L    D+
Sbjct: 1392 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1431

Query: 527  LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
            LV   +    L     + N E   R       E +  + +      R   EAR + +  L
Sbjct: 1432 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 586  -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
             L + L  A EA      T     +    L S   D  +    +      +  Q++ ++ 
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546

Query: 644  AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
             ++   EL  +  A+++    ++ + +AL  +    +  L  + EQ    R  L+     
Sbjct: 1547 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 704  AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
             E  L + +     ++A+      KL  +LK L+  A +    R     +  +   Q+ +
Sbjct: 1601 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 764  MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
             QR+L   ED + + + +   A + +K A +   +L++L  +     RA+
Sbjct: 1657 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)

Query: 6    EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
            EEEE AR                     LVM+ Q   L  E K L   +++ T    +  
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 45   EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
            E    + + K++ +    ELEV     E  R E+E+LK    G A   H+++ AD +++ 
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1078

Query: 101  ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
              L  + A KE+     +  L  E+ Q  N L   +     ++ + ++L   +      E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 158  IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
             Q+  L ++++  K      L   +  +E     +++V+VL++  ++ E   HE +  E 
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1197

Query: 217  -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
                 +  E L  QLE   R K   + +++ LE+    L  E       ++E+ H     
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 269  DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
            ++          DG     + +D   +  N+ E+ V G  +    K     K        
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1316

Query: 325  LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
            L      L  +   +LN+S        E   L+ QL         +ER  + L   L D+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376

Query: 370  QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
            +K+L+    T  +L E +++  +  ENL+     Q  +E+  A D  EK ++   ++ D 
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
              VD++    L         +  +L  + K + S +    +  EA+  E++ +  +  +A
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 481  LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
            L E +   E+  R ++ L A +E  +    DV        +++ +L    +E+ T  EEL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 535  ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
                     A L   V M       +   D     +    +     R   E         
Sbjct: 1552 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 586  LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
              + L A    + +G   D      S+             L + + D +RE  +      
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 629  NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
             + A  ++  K  ++      +L     A++      D +KE L EE   L S LS    
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1723

Query: 689  QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
                 R  L+  K+  E  +A L+ + E E+             T+   +L NEL   + 
Sbjct: 1724 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 739  DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
             A    S R     +  E  ++L EM+          +AA E +   L   +    ++K 
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 791  ALTQRLE 797
            A T+ L+
Sbjct: 1839 AATKSLK 1845



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 59/291 (20%), Positives = 136/291 (46%), Gaps = 14/291 (4%)

Query: 14   VMEAQPEWLRAEVKRLSHELA-ETTREKIQAAEYGL-AVLEEKHQLKLQFEELEVDYEAI 71
            +M+ Q +   AE  R   +L  E   E++ ++  G  A+ +EK +L+ +  +LE + E  
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748

Query: 72   RSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV 131
            +  ME + +   +A T   +  ++  + E S  Q++ S  Q   R+  EL+++L ++   
Sbjct: 1749 QGNMEAMSDRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807

Query: 132  LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISL 191
            + +       +A++  ++ ++ + VE +    +   K  K ++ +L +   ++E+E    
Sbjct: 1808 VKSKFKST--IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865

Query: 192  QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
            ++      +     + LK +++  EEE++ +N+        +   +R+L+EA E+ +   
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------RRKLQRELDEATESNEAMG 1918

Query: 252  EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
             + N+L+ +L        SF  S        ++ +D + E  +  +A  NG
Sbjct: 1919 REVNALKSKLRR--GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNG 1967



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)

Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
           K+K LL   R  E++      L+  K+  + A   LK + E + + +TE    L+ +L+A
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898

Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
             E  A    +R   A +  E    L EM+ +L   ED  + L +  +   QQ L L ++
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
           LE  E   ++ +  +  A  K K
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIK 981


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)

Query: 35   ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
            + T+E+ Q AE  L  LE+KH       +L  +   ++ +++   E + +A     ++AA
Sbjct: 869  QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922

Query: 95   DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
              +  EE L +  A  E+   R   +LQ E K++   + + + + E   +  Q+L+    
Sbjct: 923  KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 155  NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
              E +  +L D+I         L+ D   ++L +E   L++++S L  N  E E     +
Sbjct: 982  TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 213  KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
             +L+ + E + S+LE  ++ +E S ++LE+    L+ +     EQ   L+ +++  + + 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1091

Query: 269  DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
             +     L  +L   +  D+ A+ NN      + E  ++  +    ++    NK    K+
Sbjct: 1092 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 323  EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
            + L     +L ++L   L+ +  Q   Q+L     ++  +L  A  ++T+      +   
Sbjct: 1150 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 381  SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
             +  + V  LTE L   +R +A+      LD  K     E+ D                 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1243

Query: 441  VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
                 AGELR   +A       +E +H  +K + EA+ Q L  K S  E+A  +  + + 
Sbjct: 1244 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1290

Query: 501  RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
            +L+ E++ V+ +  E +G       ++ + S +L +      +   ET  ++ +   +  
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1346

Query: 561  QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
            Q    R S   +   E   +++   L + +                    S+L   LSD 
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1383

Query: 621  RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
            +++  +  + +  + +  K  Q  ++  T+   ++ A+ +    ++K K  L +E+  L 
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1440

Query: 681  SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
              L  +R+ ++ L +   K ++  AE    N+ SKY +E+                 A  
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 723  TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
             E  ++ + E       LKA  ED  +               +    T+ +E  TQL+E+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 765  QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
            + +L A ED K               + L +      +++  L ++L   E + E  R+ 
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618

Query: 810  RAKAAPKTK 818
            RA AA   K
Sbjct: 1619 RALAAAAKK 1627



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 185/868 (21%), Positives = 341/868 (39%), Gaps = 123/868 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
            + E  AR   E Q   L  E++ L  EL +T     T+++++A  E  + VL++    + 
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            +  E +V  + +R +  Q  E   +     K+  A+ +  +++L +E+A           
Sbjct: 1195 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1241

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            +L  EL+ L       + + ++L +  QEL+    + E  R  L D + +          
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1291

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
                       LQ +V  +     E EG   +  +L ++   L+SQL+D   L +   RQ
Sbjct: 1292 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 240  LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
                   L+   E++NSL+ +L   M    +      H+S   ++ S D+ +   D  + 
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1393

Query: 300  VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
            V   E G          L +   +   +  K E         + DL+ +L+     +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K +++  Q+  E+  + +   D + + E      +E +EK T+    LS  R L+ + E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1504

Query: 406  RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
             +  L+          +D  S +D    + +E++      L  +      +  EL ++L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1563

Query: 455  ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
            A        E      KG++E + QA  E+      +  RQ  E    LE E K+ +  A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623

Query: 514  GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
               +        L +  D  +   EE       +           M D+ RE +      
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1675

Query: 568  SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
                 T+ E    A+   + ++ L + L A E  R  AD    + +    SSL   + L 
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 619  D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
            D  RR    I  L   + ++  +++A  DR  + ++Q    S EL        K++ A  
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795

Query: 674  EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
            +   + K L S   E    +++  K+     E  +A L+ + E E          L+ + 
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 734  KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
            K LKE        R M   +  + ++   ++ +++RQL  AE+E + +N     A ++KL
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1910

Query: 791  ALTQRLELLELDHEQTRRGRAKAAPKTK 818
                + EL E        GR   A K+K
Sbjct: 1911 ----QRELDEATESNEAMGREVNALKSK 1934



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +E +   L  E   L  +L   T    +A E  + +  +K +L+    E+E       + 
Sbjct: 885  LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 937

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
            +E+ ++   Q     KK+A      EE L +E A++++  + KV       +L+ E+   
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997

Query: 126  ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
                           +++ ++ TN   E E+   L  +  + + +   +E++  +     
Sbjct: 998  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057

Query: 168  KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
            +E +  + +L  D S+  E+   LQ Q++ L+ Q   + E L+  + RL++E    N+ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 227  -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
                               E A R K E  +R L E LE LKTE E        +  LR 
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 260  ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
            +    +++        L  +LD    S +A       +     E L    E    AK  L
Sbjct: 1178 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 314  DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
            D    T +KE          +DL  EL +                +++Q+L+ +    ER
Sbjct: 1230 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 358  EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
             +A L   +   Q ++E   G L+E + K  +L +++++L  +LQ ++E      RQ   
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 411  DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
             + K R   E+     D  + ++   + L         +  + +++L+   ST EA E  
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1398

Query: 467  HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
              E K R++ E + LT++    EKA+  D     +LEK           T+  L    D+
Sbjct: 1399 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1438

Query: 527  LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
            LV   +    L     + N E   R       E +  + +      R   EAR + +  L
Sbjct: 1439 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 586  -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
             L + L  A EA      T     +    L S   D  +    +      +  Q++ ++ 
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553

Query: 644  AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
             ++   EL  +  A+++    ++ + +AL  +    +  L  + EQ    R  L+     
Sbjct: 1554 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 704  AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
             E  L + +     ++A+      KL  +LK L+  A +    R     +  +   Q+ +
Sbjct: 1608 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 764  MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
             QR+L   ED + + + +   A + +K A +   +L++L  +     RA+
Sbjct: 1664 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)

Query: 6    EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
            EEEE AR                     LVM+ Q   L  E K L   +++ T    +  
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 45   EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
            E    + + K++ +    ELEV     E  R E+E+LK    G A   H+++ AD +++ 
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1085

Query: 101  ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
              L  + A KE+     +  L  E+ Q  N L   +     ++ + ++L   +      E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 158  IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
             Q+  L ++++  K      L   +  +E     +++V+VL++  ++ E   HE +  E 
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1204

Query: 217  -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
                 +  E L  QLE   R K   + +++ LE+    L  E       ++E+ H     
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 269  DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
            ++          DG     + +D   +  N+ E+ V G  +    K     K        
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1323

Query: 325  LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
            L      L  +   +LN+S        E   L+ QL         +ER  + L   L D+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383

Query: 370  QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
            +K+L+    T  +L E +++  +  ENL+     Q  +E+  A D  EK ++   ++ D 
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
              VD++    L         +  +L  + K + S +    +  EA+  E++ +  +  +A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 481  LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
            L E +   E+  R ++ L A +E  +    DV        +++ +L    +E+ T  EEL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 535  ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
                     A L   V M       +   D     +    +     R   E         
Sbjct: 1559 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 586  LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
              + L A    + +G   D      S+             L + + D +RE  +      
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 629  NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
             + A  ++  K  ++      +L     A++      D +KE L EE   L S LS    
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1730

Query: 689  QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
                 R  L+  K+  E  +A L+ + E E+             T+   +L NEL   + 
Sbjct: 1731 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 739  DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
             A    S R     +  E  ++L EM+          +AA E +   L   +    ++K 
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 791  ALTQRLE 797
            A T+ L+
Sbjct: 1846 AATKSLK 1852



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 59/291 (20%), Positives = 136/291 (46%), Gaps = 14/291 (4%)

Query: 14   VMEAQPEWLRAEVKRLSHELA-ETTREKIQAAEYGL-AVLEEKHQLKLQFEELEVDYEAI 71
            +M+ Q +   AE  R   +L  E   E++ ++  G  A+ +EK +L+ +  +LE + E  
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755

Query: 72   RSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV 131
            +  ME + +   +A T   +  ++  + E S  Q++ S  Q   R+  EL+++L ++   
Sbjct: 1756 QGNMEAMSDRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814

Query: 132  LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISL 191
            + +       +A++  ++ ++ + VE +    +   K  K ++ +L +   ++E+E    
Sbjct: 1815 VKSKFKST--IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872

Query: 192  QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
            ++      +     + LK +++  EEE++ +N+        +   +R+L+EA E+ +   
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------RRKLQRELDEATESNEAMG 1925

Query: 252  EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
             + N+L+ +L        SF  S        ++ +D + E  +  +A  NG
Sbjct: 1926 REVNALKSKLRR--GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNG 1974



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)

Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
           K+K LL   R  E++      L+  K+  + A   LK + E + + +TE    L+ +L+A
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905

Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
             E  A    +R   A +  E    L EM+ +L   ED  + L +  +   QQ L L ++
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
           LE  E   ++ +  +  A  K K
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIK 988


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)

Query: 35   ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
            + T+E+ Q AE  L  LE+KH       +L  +   ++ +++   E + +A     ++AA
Sbjct: 869  QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922

Query: 95   DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
              +  EE L +  A  E+   R   +LQ E K++   + + + + E   +  Q+L+    
Sbjct: 923  KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981

Query: 155  NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
              E +  +L D+I         L+ D   ++L +E   L++++S L  N  E E     +
Sbjct: 982  TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032

Query: 213  KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
             +L+ + E + S+LE  ++ +E S ++LE+    L+ +     EQ   L+ +++  + + 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1091

Query: 269  DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
             +     L  +L   +  D+ A+ NN      + E  ++  +    ++    NK    K+
Sbjct: 1092 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 323  EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
            + L     +L ++L   L+ +  Q   Q+L     ++  +L  A  ++T+      +   
Sbjct: 1150 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 381  SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
             +  + V  LTE L   +R +A+      LD  K     E+ D                 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1243

Query: 441  VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
                 AGELR   +A       +E +H  +K + EA+ Q L  K S  E+A  +  + + 
Sbjct: 1244 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1290

Query: 501  RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
            +L+ E++ V+ +  E +G       ++ + S +L +      +   ET  ++ +   +  
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1346

Query: 561  QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
            Q    R S   +   E   +++   L + +                    S+L   LSD 
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1383

Query: 621  RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
            +++  +  + +  + +  K  Q  ++  T+   ++ A+ +    ++K K  L +E+  L 
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1440

Query: 681  SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
              L  +R+ ++ L +   K ++  AE    N+ SKY +E+                 A  
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 723  TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
             E  ++ + E       LKA  ED  +               +    T+ +E  TQL+E+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 765  QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
            + +L A ED K               + L +      +++  L ++L   E + E  R+ 
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618

Query: 810  RAKAAPKTK 818
            RA AA   K
Sbjct: 1619 RALAAAAKK 1627



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 186/872 (21%), Positives = 342/872 (39%), Gaps = 123/872 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
            + E  AR   E Q   L  E++ L  EL +T     T+++++A  E  + VL++    + 
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            +  E +V  + +R +  Q  E   +     K+  A+ +  +++L +E+A           
Sbjct: 1195 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1241

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            +L  EL+ L       + + ++L +  QEL+    + E  R  L D + +          
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1291

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
                       LQ +V  +     E EG   +  +L ++   L+SQL+D   L +   RQ
Sbjct: 1292 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1337

Query: 240  LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
                   L+   E++NSL+ +L   M    +      H+S   ++ S D+ +   D  + 
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1393

Query: 300  VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
            V   E G          L +   +   +  K E         + DL+ +L+     +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K +++  Q+  E+  + +   D + + E      +E +EK T+    LS  R L+ + E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1504

Query: 406  RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
             +  L+          +D  S +D    + +E++      L  +      +  EL ++L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1563

Query: 455  ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
            A        E      KG++E + QA  E+      +  RQ  E    LE E K+ +  A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623

Query: 514  GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
               +        L +  D  +   EE       +           M D+ RE +      
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1675

Query: 568  SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
                 T+ E    A+   + ++ L + L A E  R  AD    + +    SSL   + L 
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 619  D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
            D  RR    I  L   + ++  +++A  DR  + ++Q    S EL        K++ A  
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795

Query: 674  EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
            +   + K L S   E    +++  K+     E  +A L+ + E E          L+ + 
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 734  KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
            K LKE        R M   +  + ++   ++ +++RQL  AE+E + +N     A ++KL
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1910

Query: 791  ALTQRLELLELDHEQTRRGRAKAAPKTKPATP 822
                + EL E        GR   A K+K   P
Sbjct: 1911 ----QRELDEATESNEAMGREVNALKSKLRGP 1938



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +E +   L  E   L  +L   T    +A E  + +  +K +L+    E+E       + 
Sbjct: 885  LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 937

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
            +E+ ++   Q     KK+A      EE L +E A++++  + KV       +L+ E+   
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997

Query: 126  ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
                           +++ ++ TN   E E+   L  +  + + +   +E++  +     
Sbjct: 998  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057

Query: 168  KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
            +E +  + +L  D S+  E+   LQ Q++ L+ Q   + E L+  + RL++E    N+ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 227  -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
                               E A R K E  +R L E LE LKTE E        +  LR 
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 260  ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
            +    +++        L  +LD    S +A       +     E L    E    AK  L
Sbjct: 1178 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 314  DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
            D    T +KE          +DL  EL +                +++Q+L+ +    ER
Sbjct: 1230 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280

Query: 358  EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
             +A L   +   Q ++E   G L+E + K  +L +++++L  +LQ ++E      RQ   
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340

Query: 411  DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
             + K R   E+     D  + ++   + L         +  + +++L+   ST EA E  
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1398

Query: 467  HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
              E K R++ E + LT++    EKA+  D     +LEK           T+  L    D+
Sbjct: 1399 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1438

Query: 527  LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
            LV   +    L     + N E   R       E +  + +      R   EAR + +  L
Sbjct: 1439 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 586  -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
             L + L  A EA      T     +    L S   D  +    +      +  Q++ ++ 
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553

Query: 644  AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
             ++   EL  +  A+++    ++ + +AL  +    +  L  + EQ    R  L+     
Sbjct: 1554 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1607

Query: 704  AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
             E  L + +     ++A+      KL  +LK L+  A +    R     +  +   Q+ +
Sbjct: 1608 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 764  MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
             QR+L   ED + + + +   A + +K A +   +L++L  +     RA+
Sbjct: 1664 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)

Query: 6    EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
            EEEE AR                     LVM+ Q   L  E K L   +++ T    +  
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 45   EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
            E    + + K++ +    ELEV     E  R E+E+LK    G A   H+++ AD +++ 
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1085

Query: 101  ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
              L  + A KE+     +  L  E+ Q  N L   +     ++ + ++L   +      E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145

Query: 158  IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
             Q+  L ++++  K      L   +  +E     +++V+VL++  ++ E   HE +  E 
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1204

Query: 217  -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
                 +  E L  QLE   R K   + +++ LE+    L  E       ++E+ H     
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 269  DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
            ++          DG     + +D   +  N+ E+ V G  +    K     K        
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1323

Query: 325  LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
            L      L  +   +LN+S        E   L+ QL         +ER  + L   L D+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383

Query: 370  QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
            +K+L+    T  +L E +++  +  ENL+     Q  +E+  A D  EK ++   ++ D 
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
              VD++    L         +  +L  + K + S +    +  EA+  E++ +  +  +A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 481  LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
            L E +   E+  R ++ L A +E  +    DV        +++ +L    +E+ T  EEL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558

Query: 535  ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
                     A L   V M       +   D     +    +     R   E         
Sbjct: 1559 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616

Query: 586  LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
              + L A    + +G   D      S+             L + + D +RE  +      
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 629  NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
             + A  ++  K  ++      +L     A++      D +KE L EE   L S LS    
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1730

Query: 689  QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
                 R  L+  K+  E  +A L+ + E E+             T+   +L NEL   + 
Sbjct: 1731 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 739  DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
             A    S R     +  E  ++L EM+          +AA E +   L   +    ++K 
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 791  ALTQRLE 797
            A T+ L+
Sbjct: 1846 AATKSLK 1852



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)

Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
           K+K LL   R  E++      L+  K+  + A   LK + E + + +TE    L+ +L+A
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905

Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
             E  A    +R   A +  E    L EM+ +L   ED  + L +  +   QQ L L ++
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965

Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
           LE  E   ++ +  +  A  K K
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIK 988


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)

Query: 35   ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
            + T+E+ Q AE  L  LE+KH       +L  +   ++ +++   E + +A     ++AA
Sbjct: 862  QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915

Query: 95   DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
              +  EE L +  A  E+   R   +LQ E K++   + + + + E   +  Q+L+    
Sbjct: 916  KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974

Query: 155  NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
              E +  +L D+I         L+ D   ++L +E   L++++S L  N  E E     +
Sbjct: 975  TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025

Query: 213  KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
             +L+ + E + S+LE  ++ +E S ++LE+    L+ +     EQ   L+ +++  + + 
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1084

Query: 269  DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
             +     L  +L   +  D+ A+ NN      + E  ++  +    ++    NK    K+
Sbjct: 1085 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 323  EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
            + L     +L ++L   L+ +  Q   Q+L     ++  +L  A  ++T+      +   
Sbjct: 1143 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 381  SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
             +  + V  LTE L   +R +A+      LD  K     E+ D                 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1236

Query: 441  VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
                 AGELR   +A       +E +H  +K + EA+ Q L  K S  E+A  +  + + 
Sbjct: 1237 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1283

Query: 501  RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
            +L+ E++ V+ +  E +G       ++ + S +L +      +   ET  ++ +   +  
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1339

Query: 561  QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
            Q    R S   +   E   +++   L + +                    S+L   LSD 
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1376

Query: 621  RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
            +++  +  + +  + +  K  Q  ++  T+   ++ A+ +    ++K K  L +E+  L 
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1433

Query: 681  SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
              L  +R+ ++ L +   K ++  AE    N+ SKY +E+                 A  
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 723  TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
             E  ++ + E       LKA  ED  +               +    T+ +E  TQL+E+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 765  QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
            + +L A ED K               + L +      +++  L ++L   E + E  R+ 
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611

Query: 810  RAKAAPKTK 818
            RA AA   K
Sbjct: 1612 RALAAAAKK 1620



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 186/872 (21%), Positives = 342/872 (39%), Gaps = 123/872 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
            + E  AR   E Q   L  E++ L  EL +T     T+++++A  E  + VL++    + 
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            +  E +V  + +R +  Q  E   +     K+  A+ +  +++L +E+A           
Sbjct: 1188 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1234

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            +L  EL+ L       + + ++L +  QEL+    + E  R  L D + +          
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1284

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
                       LQ +V  +     E EG   +  +L ++   L+SQL+D   L +   RQ
Sbjct: 1285 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1330

Query: 240  LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
                   L+   E++NSL+ +L   M    +      H+S   ++ S D+ +   D  + 
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1386

Query: 300  VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
            V   E G          L +   +   +  K E         + DL+ +L+     +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K +++  Q+  E+  + +   D + + E      +E +EK T+    LS  R L+ + E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1497

Query: 406  RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
             +  L+          +D  S +D    + +E++      L  +      +  EL ++L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1556

Query: 455  ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
            A        E      KG++E + QA  E+      +  RQ  E    LE E K+ +  A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616

Query: 514  GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
               +        L +  D  +   EE       +           M D+ RE +      
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1668

Query: 568  SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
                 T+ E    A+   + ++ L + L A E  R  AD    + +    SSL   + L 
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 619  D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
            D  RR    I  L   + ++  +++A  DR  + ++Q    S EL        K++ A  
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788

Query: 674  EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
            +   + K L S   E    +++  K+     E  +A L+ + E E          L+ + 
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 734  KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
            K LKE        R M   +  + ++   ++ +++RQL  AE+E + +N     A ++KL
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1903

Query: 791  ALTQRLELLELDHEQTRRGRAKAAPKTKPATP 822
                + EL E        GR   A K+K   P
Sbjct: 1904 ----QRELDEATESNEAMGREVNALKSKLRGP 1931



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +E +   L  E   L  +L   T    +A E  + +  +K +L+    E+E       + 
Sbjct: 878  LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 930

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
            +E+ ++   Q     KK+A      EE L +E A++++  + KV       +L+ E+   
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990

Query: 126  ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
                           +++ ++ TN   E E+   L  +  + + +   +E++  +     
Sbjct: 991  DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050

Query: 168  KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
            +E +  + +L  D S+  E+   LQ Q++ L+ Q   + E L+  + RL++E    N+ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 227  -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
                               E A R K E  +R L E LE LKTE E        +  LR 
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 260  ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
            +    +++        L  +LD    S +A       +     E L    E    AK  L
Sbjct: 1171 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 314  DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
            D    T +KE          +DL  EL +                +++Q+L+ +    ER
Sbjct: 1223 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273

Query: 358  EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
             +A L   +   Q ++E   G L+E + K  +L +++++L  +LQ ++E      RQ   
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333

Query: 411  DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
             + K R   E+     D  + ++   + L         +  + +++L+   ST EA E  
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1391

Query: 467  HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
              E K R++ E + LT++    EKA+  D     +LEK           T+  L    D+
Sbjct: 1392 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1431

Query: 527  LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
            LV   +    L     + N E   R       E +  + +      R   EAR + +  L
Sbjct: 1432 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 586  -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
             L + L  A EA      T     +    L S   D  +    +      +  Q++ ++ 
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546

Query: 644  AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
             ++   EL  +  A+++    ++ + +AL  +    +  L  + EQ    R  L+     
Sbjct: 1547 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1600

Query: 704  AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
             E  L + +     ++A+      KL  +LK L+  A +    R     +  +   Q+ +
Sbjct: 1601 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 764  MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
             QR+L   ED + + + +   A + +K A +   +L++L  +     RA+
Sbjct: 1657 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)

Query: 6    EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
            EEEE AR                     LVM+ Q   L  E K L   +++ T    +  
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 45   EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
            E    + + K++ +    ELEV     E  R E+E+LK    G A   H+++ AD +++ 
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1078

Query: 101  ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
              L  + A KE+     +  L  E+ Q  N L   +     ++ + ++L   +      E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138

Query: 158  IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
             Q+  L ++++  K      L   +  +E     +++V+VL++  ++ E   HE +  E 
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1197

Query: 217  -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
                 +  E L  QLE   R K   + +++ LE+    L  E       ++E+ H     
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 269  DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
            ++          DG     + +D   +  N+ E+ V G  +    K     K        
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1316

Query: 325  LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
            L      L  +   +LN+S        E   L+ QL         +ER  + L   L D+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376

Query: 370  QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
            +K+L+    T  +L E +++  +  ENL+     Q  +E+  A D  EK ++   ++ D 
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
              VD++    L         +  +L  + K + S +    +  EA+  E++ +  +  +A
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 481  LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
            L E +   E+  R ++ L A +E  +    DV        +++ +L    +E+ T  EEL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551

Query: 535  ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
                     A L   V M       +   D     +    +     R   E         
Sbjct: 1552 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609

Query: 586  LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
              + L A    + +G   D      S+             L + + D +RE  +      
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 629  NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
             + A  ++  K  ++      +L     A++      D +KE L EE   L S LS    
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1723

Query: 689  QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
                 R  L+  K+  E  +A L+ + E E+             T+   +L NEL   + 
Sbjct: 1724 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 739  DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
             A    S R     +  E  ++L EM+          +AA E +   L   +    ++K 
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 791  ALTQRLE 797
            A T+ L+
Sbjct: 1839 AATKSLK 1845



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)

Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
           K+K LL   R  E++      L+  K+  + A   LK + E + + +TE    L+ +L+A
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898

Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
             E  A    +R   A +  E    L EM+ +L   ED  + L +  +   QQ L L ++
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958

Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
           LE  E   ++ +  +  A  K K
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIK 981


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 117/578 (20%), Positives = 256/578 (44%), Gaps = 86/578 (14%)

Query: 2    SAPSEEEEYARL--VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLK 58
            S   E+++  RL  V++++ + L+  +K +  +  ET  E+++ A   L   EE  ++L+
Sbjct: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET-EEELKVAHCCLKEQEETINELR 1497

Query: 59   LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRK 117
            +   E E +   I+ ++E + +                    ++ IQE   KE Q+ +++
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKL------------------QNKIQEIYEKEEQFNIKQ 1539

Query: 118  VLELQ---TELKQ---------------------LRNVLTNTQSENERLASVAQELKEIN 153
            + E+Q    ELKQ                     L N L  +Q E + +    +E+K + 
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599

Query: 154  QNVEIQRGRLRDDIKEY--KFREARLLQDYSELEEENIS-LQKQVSVLRQNQVEFEGLKH 210
            + ++I+R +L+++ KE   K +E++  ++Y  L+   ++  Q+++  +   + +FE  K 
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQ-EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658

Query: 211  EIKRLEEE----TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQ-KNSLRKELSHYM 265
             ++ +E E    T+ L+  LE+ +R        L    ETLK ER+Q K +LR+ ++  +
Sbjct: 1659 NLENIETENIRLTQILHENLEE-MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717

Query: 266  SINDSFYTSHLHV-----SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTP 320
               +     H+H+     ++D  K     +E  N+   +    EH   A    D K    
Sbjct: 1718 EKQEELKIVHMHLKEHQETID--KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE 1775

Query: 321  KKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
             +              ++ +++ E Q+   +L  +  EK   L+ +   QK LE++   L
Sbjct: 1776 LR--------------IAHMHLKEQQETIDKLRGIVSEKTDKLSNM---QKDLENSNAKL 1818

Query: 381  SEQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKY 439
             E+ +++      L  L++ +  ++++ + ++  K +   +     +++I     LA K 
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLN-LAQKL 1877

Query: 440  HVAVAEAGEL---REQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDR 496
            H  + E   +   R+ L+ +  T +    Q  E     +A    + +++      S++ +
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK 1937

Query: 497  ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
            E + +L +++ + +    + Q  L  ++DEL    +EL
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 181/867 (20%), Positives = 345/867 (39%), Gaps = 168/867 (19%)

Query: 29   LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTN 88
            L   +AE  + K    E     +E + +L+L  +EL+   E +  E     +  G+    
Sbjct: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118

Query: 89   HKKVAADGESREESL------------IQESASKEQYYVRKVLELQTELKQLRNVLTNTQ 136
              ++A   E  +E              +QE  S+ Q  + ++  L+ ELK     L + +
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME 1178

Query: 137  SENERLASVAQE--------------LKEINQNVEIQRGRLRDDIKEYKFREARLLQDYS 182
            +E   LA    E              LKE+ ++ E +R  LR  I+E    EA  LQ   
Sbjct: 1179 TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI---EATGLQTKE 1235

Query: 183  ELEEENISL---QKQVSVLRQNQ-------VEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
            EL+  +I L   Q+ +  LR++        +  + L+    +L+EE   L+ + E    +
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295

Query: 233  KEISERQ-LEEALETLKTEREQKNS--LRKELSHYMSINDSFYTSH-----LHVSLDGLK 284
            KE+SE Q     LE L  +   K+S  L +     + +N+ F  S      L    D LK
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355

Query: 285  FSDDAAEPNND------AEALVNGFEHGGLAKLPL-----DNKTS--TPKKEGLAPPSPS 331
               +A E  +D       E L    E     +  L     DN+T+    + E   P   +
Sbjct: 1356 TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSA 1415

Query: 332  LVSDLLSELNIS------------------EIQKLKQQLM----QMEREKAGLLATLQDT 369
            L+   +  L +S                  ++Q+L++ L     Q++     ++A   +T
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET 1475

Query: 370  QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
            +++L+     L EQ+E +  L  NLS      ++ ++Q    N+K ++  +         
Sbjct: 1476 EEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ--------- 1526

Query: 430  NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE 489
               EI   +    + +  E++E++  L+   E R+A+ +  +   E++   LT ++    
Sbjct: 1527 ---EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS-IESKMLELTNRL---- 1578

Query: 490  KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVT-FSEELANLYHHVCM-CNNE 547
            + S+++ +++ + ++E+K+V +     +  L     E+V    E     Y  + M   NE
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638

Query: 548  TPNRVM-LDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSS 606
            T  ++  +++ +E       T      + E    R   +L + L   E  R+        
Sbjct: 1639 TQEKMCEIEHLKE----QFETQKLNLENIETENIRLTQILHENL---EEMRS-------- 1683

Query: 607  PSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTTELSRQRIASQELGPAV 665
                      ++  R +  ++   + + RDQ+K +L+  + R  E        QE    V
Sbjct: 1684 ----------VTKERDDLRSVEETLKVERDQLKENLRETITRDLE-------KQEELKIV 1726

Query: 666  DKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTET 725
                +   E I KL+ ++S K  +I                  +N++   E+    +   
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKTNEI------------------SNMQKDLEHSNDALKAQ 1768

Query: 726  MMKLRNELKA----LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSL 781
             +K++ EL+     LKE   T   LR + + + D    +L  MQ+ L       +  N+ 
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD----KLSNMQKDL-------ENSNAK 1817

Query: 782  LRMAIQQKLALTQRLELLELDHEQTRR 808
            L+  IQ+  A   +L  L+ D  +T++
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQK 1844



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 166/832 (19%), Positives = 332/832 (39%), Gaps = 136/832 (16%)

Query: 53   EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
            E + L+  ++ L +DYE +R+E E+++           K+    +  E   ++    K+Q
Sbjct: 499  ELNSLRADYDNLVLDYEQLRTEKEEME----------LKLKEKNDLDEFEALERKTKKDQ 548

Query: 113  YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
                  ++L  E+  L+N++ + +  N+ L +      E+ +  E Q  +L++ I   K 
Sbjct: 549  -----EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKL 603

Query: 173  REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQ-LEDAIR 231
               ++   YS    E+I   KQ   ++Q   + E +  + KR   E+ +L S+ LE   +
Sbjct: 604  ENIKMDLSYS---LESIEDPKQ---MKQTLFDAETVALDAKR---ESAFLRSENLELKEK 654

Query: 232  LKEISE--RQLEEALETLKTEREQKNSLR-----------KELSHYMSINDSFYTSHL-- 276
            +KE++   +Q+E  ++  +++ E K  ++            E++   S+ D      L  
Sbjct: 655  MKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714

Query: 277  HVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK--LPLDNKTSTPKK-EGLAPPSPSLV 333
            ++ L+G K +D   E N + E      E+  L +  + L    S P + E L       +
Sbjct: 715  NLELEG-KITDLQKELNKEVE------ENEALREEVILLSELKSLPSEVERLRKE----I 763

Query: 334  SDLLSELNI--SEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
             D   EL+I  SE  KL  +++  E    GLL  +  T+  L  T+ +     ++     
Sbjct: 764  QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF---- 819

Query: 392  ENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE 451
            +N   L      K +    +NE+             +I      A K+    +  G L+ 
Sbjct: 820  QNFKTLHMDFEQKYKMVLEENER----------MNQEIVNLSKEAQKFD---SSLGALKT 866

Query: 452  QLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSD 511
            +L       + +  +  E     E   + L  + S L+   R+   +  +L++ L++V  
Sbjct: 867  ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926

Query: 512  VAGE------TQGSLSVAQDEL-----------VTFSEELANLYHHVCMCNNETPNRVML 554
            +  E       Q SL + +D+L           +   E+L N    +   + ET N +  
Sbjct: 927  LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ-HQETINTLKS 985

Query: 555  DYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLP 614
                E           G T  E + +   I   + L A           D+         
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045

Query: 615  SPLSDPRREPMNIYNLIAIIRDQIK-----HLQAAVDRTTEL--------SRQRIASQEL 661
              L   + E   +   +   ++Q+K     +++  ++   EL         +Q I +QE 
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 662  GPAVDK--------DKEALMEEILKLKS-LLSTKREQITTLRTVLKANKQTAEVALANLK 712
              A+ K        D+ A +EE LK KS  L  K++Q+  ++  + +  Q     + NLK
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM-SEMQKKINEIENLK 1164

Query: 713  SKYEN----------EKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDE---YIT 759
            ++ +N          E+  + + + +   E+K++ ++      L+  F T  D    YI 
Sbjct: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224

Query: 760  QLD----EMQRQLAAA----EDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
            +++    + + +L  A    ++ ++T++  LR ++ +K A     + LE  H
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEKTAQIINTQDLEKSH 1275



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 147/810 (18%), Positives = 309/810 (38%), Gaps = 75/810 (9%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREK-------IQAAEYGLAVLEEKHQLKLQFEELEVD 67
            + ++ E LR E++  S EL   T EK       +        +LEE  + K      + +
Sbjct: 752  LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811

Query: 68   YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQ 127
            Y++   E +  K         +K V  + E   + ++  S  + Q +   +  L+TEL  
Sbjct: 812  YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS-KEAQKFDSSLGALKTELSY 870

Query: 128  LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
                   TQ   E+   V + L E+ Q  E    R  D   +   RE  L+ +       
Sbjct: 871  ------KTQELQEKTREVQERLNEMEQLKEQLENR--DSTLQTVEREKTLITE------- 915

Query: 188  NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
               LQ+ +  ++    E + LK   + L+ E + L S + D + +   ++ QL  ALE+L
Sbjct: 916  --KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973

Query: 248  KTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGG 307
            K  +E  N+L+ ++S  +S N              L   ++  E  ++ +  + G +   
Sbjct: 974  KQHQETINTLKSKISEEVSRN--------------LHMEENTGETKDEFQQKMVGIDKKQ 1019

Query: 308  LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQ 367
              +       +   K+         +  L+ E N  + Q L+  + + E+ K  L   ++
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ-QMLESVIAEKEQLKTDLKENIE 1078

Query: 368  ---DTQKQLEHTRGSLSEQQEKVTRLTENLSALRR---LQASKERQTALDNEKDRDSHED 421
               + Q++L      L +QQE V +  E   A+++   L  + +R   ++ +    S + 
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQ--EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136

Query: 422  GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQH---AEEKGRYEAEG 478
             +  +  +N  E ++ +    + E   L+ +LK    T E  E +    A++      E 
Sbjct: 1137 QEKQQQLLNVQEEMS-EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195

Query: 479  QALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
            +++T++  +L++  +        L   ++++     +T+  L +A   L    E +  L 
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255

Query: 539  HHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRA 598
              V   + +T   +      +         P      E        LLP      E    
Sbjct: 1256 RSV---SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE--------LLPNVKEVSETQET 1304

Query: 599  DGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS 658
                   +    +   + L+    E + +       +++IK L      T E    +   
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL------TKERDNLKTIK 1358

Query: 659  QELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKS----K 714
            + L    D+ KE + E + K++   S + + +       +  K  +E+     K     +
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418

Query: 715  YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
             E E   +++ + +  +E+K++ ++      L+ +  +  D+    + E+  +    E+E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 775  KKTLNSLLRMAIQQKLALTQRLELLELDHE 804
             K  +  L+   Q++     R+ L E + E
Sbjct: 1479 LKVAHCCLKE--QEETINELRVNLSEKETE 1506



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 163/860 (18%), Positives = 338/860 (39%), Gaps = 123/860 (14%)

Query: 9    EYARLVMEAQPEWLRAEVKRLSHELAETTR-------EKIQAAEYGLAVLEEKHQLKLQF 61
            +Y  LV++   E LR E + +  +L E          E+    +  + ++ E   LK   
Sbjct: 506  DYDNLVLDY--EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563

Query: 62   EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
            +  EV  + + +E+    E   +     KK+    +S++   I+   S     +    ++
Sbjct: 564  KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623

Query: 122  QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
            +  L     V  + + E+  L S   ELKE  + +     ++ +DI+ Y+ +     +  
Sbjct: 624  KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683

Query: 182  SELEEENISLQKQVSVLRQ-----------NQVEFEGLKHEI-KRLEEETEYLNSQLEDA 229
             +LE+E  S   +++ L               +E EG   ++ K L +E E   +  E+ 
Sbjct: 684  VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743

Query: 230  IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS--LDGL---- 283
            I L E+  + L   +E L+ E + K+   +EL    S  D  ++  +H    + GL    
Sbjct: 744  ILLSEL--KSLPSEVERLRKEIQDKS---EELHIITSEKDKLFSEVVHKESRVQGLLEEI 798

Query: 284  -KFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE---------GLAPPSPSLV 333
             K  DD A   ++ ++    F++     +  + K     +E          L+  +    
Sbjct: 799  GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858

Query: 334  SDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTEN 393
            S L +    +E+    Q+L +  RE    L  ++  ++QLE+   +L   + + T +TE 
Sbjct: 859  SSLGALK--TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916

Query: 394  L--------SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
            L        +  +     K+ Q +L  E+D+   +  D   ++I+  E L      A+  
Sbjct: 917  LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL----RNALES 972

Query: 446  AGELREQLKALRS--THEAREAQHAEE-----KGRYEAEGQALTEKVSLLEK------AS 492
              + +E +  L+S  + E     H EE     K  ++ +   + +K  L  K      A 
Sbjct: 973  LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032

Query: 493  RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL-ANLYHHVCM-CNNETPN 550
             +D E++ +  K    + +     +  L    + ++   E+L  +L  ++ M   N+   
Sbjct: 1033 VKDNEIIEQQRKIFSLIQE-----KNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087

Query: 551  RVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPG 610
            R++ D  ++ Q                            ++A E   A    G+ S +  
Sbjct: 1088 RLLGDELKKQQ---------------------------EIVAQEKNHAIKKEGELSRTCD 1120

Query: 611  --SSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKD 668
              + +   L +  ++       +  +++++  +Q  ++    L +  + ++EL       
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL-KNELKNKEL------T 1173

Query: 669  KEALMEEILKLKSLLSTKREQ---ITTLRTVLKANKQTAEVALANLKSKYENEKAMVTET 725
             E +  E L+L   L+   E+   IT  R VLK  +++ E    +L+      +A   +T
Sbjct: 1174 LEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233

Query: 726  MMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLD------EMQRQLAAAEDEKKTLN 779
              +L+     LKE   T   LR   + +  + I   D      ++Q ++    +E++ L 
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293

Query: 780  SLLRMAIQQKLALTQRLELL 799
            ++  ++  Q+      LELL
Sbjct: 1294 NVKEVSETQE--TMNELELL 1311



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 157/781 (20%), Positives = 304/781 (38%), Gaps = 128/781 (16%)

Query: 52   EEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLI------- 104
            +E   LK Q EE+ ++  A   E +QL +   +     K      E+    L+       
Sbjct: 350  KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409

Query: 105  -QESASKEQYYVRKVLELQTELKQLR-----NVLTNTQSENERLASVAQELKEINQNVEI 158
             QE  +K +  V   L    ++K        N+ TN  ++  +L+     L+EI+++V  
Sbjct: 410  QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS--INLLREIDESVCS 467

Query: 159  QR---GRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRL 215
            +        D + E ++  A  L     L +ENI      S L   + +++ L  + ++L
Sbjct: 468  ESDVFSNTLDTLSEIEWNPATKL-----LNQENIE-----SELNSLRADYDNLVLDYEQL 517

Query: 216  EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSH 275
              E E      E  ++LKE ++    EALE  KT+++Q+  L  E+S+  ++       H
Sbjct: 518  RTEKE------EMELKLKEKNDLDEFEALER-KTKKDQEMQLIHEISNLKNL-----VKH 565

Query: 276  LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSD 335
              V    L+         N+  + V            L     + K E +         D
Sbjct: 566  AEVYNQDLE---------NELSSKVELLREKEDQIKKLQEYIDSQKLENIK-------MD 609

Query: 336  LLSEL-NISEIQKLKQQLMQME-------REKAGLLATLQDTQKQLEHTRGSLSEQQEKV 387
            L   L +I + +++KQ L   E       RE A L +   + +++++    +  + +  +
Sbjct: 610  LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDI 669

Query: 388  TRLTENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
                  L A +++Q    KE Q+A +      S  DG         P+ L C   +    
Sbjct: 670  QLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-------PKDLLCNLELE--- 719

Query: 446  AGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
             G++ +  K L    E  EA    E+    +E ++L  +V  L K  +   E L  +  E
Sbjct: 720  -GKITDLQKELNKEVEENEA--LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSE 776

Query: 506  LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAG 565
              K+       +  +    +E+    ++LA    +    + E  N   L    E +    
Sbjct: 777  KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY--- 833

Query: 566  RTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPM 625
                  +   E   R +  ++    L+ EA + D   G        +L + LS   +E  
Sbjct: 834  ------KMVLEENERMNQEIVN---LSKEAQKFDSSLG--------ALKTELSYKTQE-- 874

Query: 626  NIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST 685
                    ++++ + +Q  ++   +L  Q          V+++K  + E++ +    + T
Sbjct: 875  --------LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926

Query: 686  KREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSS 745
                +T  +  LK  +++ ++    LKS   +   M  +T  +LRN L++LK+   T ++
Sbjct: 927  ----LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT 982

Query: 746  LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
            L++  +          +E+ R L   E+  +T +       QQK+    + + LE  + Q
Sbjct: 983  LKSKIS----------EEVSRNLHMEENTGETKDE-----FQQKMVGIDKKQDLEAKNTQ 1027

Query: 806  T 806
            T
Sbjct: 1028 T 1028



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 109/626 (17%), Positives = 245/626 (39%), Gaps = 117/626 (18%)

Query: 17   AQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME 76
            ++ E L+ ++K  S  L++   E +  A+     LEE   +  + + L    E ++ E +
Sbjct: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906

Query: 77   QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQ 136
            QLKE+  +        A D E ++E       SKE  +   V +L+ ++ +    +++ Q
Sbjct: 1907 QLKESLQETK------ARDLEIQQELKTARMLSKE--HKETVDKLREKISEKTIQISDIQ 1958

Query: 137  SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ---- 192
             + ++     Q+  +  Q  E+Q  R+++D+     +   + Q   + E +N+S+Q    
Sbjct: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018

Query: 193  -------------KQVSVLRQNQVEFEGLKHEIKR------------------------- 214
                         +++ ++ + + E   +K  +K                          
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078

Query: 215  ---LEEETEYLNSQL-EDAIRLKEISERQLE-----EALETLKTEREQKNSLRKELSHYM 265
               L +  ++L   L E   R+KE+ +R  E     E L  L  + E++   +KELS  +
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138

Query: 266  SINDS---FYTSHL--------------HVSLDGLKF-SDDAAEPNNDAEALVNGFEHGG 307
              N S     T H+              H  +  LK+      +   +    +N FE   
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198

Query: 308  LAKLP-----------LDNKTSTPKKE----GLAPPSPSLVSDLLSELNISEIQKLK--- 349
            + ++            L      P +E     L       + ++L + + SE   +K   
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEF 2258

Query: 350  QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-----TENLSALRRLQASK 404
            QQ++   +E    L    +T+  +E  +  + ++ +++ ++        ++ +      +
Sbjct: 2259 QQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFE 2318

Query: 405  ERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH-EAR 463
            ER   +  E ++D     +  E      + L      ++A   ++    +  ++ H  +R
Sbjct: 2319 ERSATISKEWEQDLKSLKEKNEKLFKNYQTL----KTSLASGAQVNPTTQDNKNPHVTSR 2374

Query: 464  EAQHAEEKGR------YEAEGQAL--TEKVSLLEKASRQDRELLARLEKELKKVSDVAGE 515
              Q   EK R      +EA+  A+    K+  ++K      +++A+L+ ++ + +    +
Sbjct: 2375 ATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434

Query: 516  TQGSLSVAQDELV----TFSEELANL 537
            T+ ++ V QD++      + EE+ +L
Sbjct: 2435 TKETIQVLQDKVALGAKPYKEEIEDL 2460



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 74/409 (18%), Positives = 171/409 (41%), Gaps = 57/409 (13%)

Query: 27   KRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAH 86
            +R S E     ++      Y   + EE+H+   +FE   +D      E+E+ KE      
Sbjct: 2160 QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID------EVEKQKELL--IK 2211

Query: 87   TNHKKVAADGESREESLIQESASKEQYYVRKVLE---------LQTELKQLRNVLTNTQS 137
              H +   D  SRE   ++ + + +  ++ ++L+         ++TE +Q+ +       
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMD-LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270

Query: 138  ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
              E   +   +++++   ++ +  R+      +  R   ++ + +E EE + ++ K+   
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEW-- 2328

Query: 198  LRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE------R 251
                + + + LK + ++L +  + L + L    ++   ++      + +  T+      R
Sbjct: 2329 ----EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384

Query: 252  EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKL 311
            E +NSL +              S +H     +K   +  E  ND  A +        AK+
Sbjct: 2385 ELENSLHEAKE-----------SAMHKESKIIKMQKEL-EVTNDIIAKLQ-------AKV 2425

Query: 312  PLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQK 371
               NK     KE +      +   L ++    EI+ LK +L++++ EK   +   ++ +K
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVA--LGAKPYKEEIEDLKMKLVKIDLEK---MKNAKEFEK 2480

Query: 372  QLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
            ++  T+ ++  Q+E +  L EN   LRR Q +++     ++   + S++
Sbjct: 2481 EISATKATVEYQKEVIRLLREN---LRRSQQAQDTSVISEHTDPQPSNK 2526


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 175/832 (21%), Positives = 321/832 (38%), Gaps = 128/832 (15%)

Query: 50   VLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESAS 109
            + EEK +++ +  E     EA  +++EQL     Q     ++V A     +E+L++E A+
Sbjct: 685  IQEEKEEIQKKLSESRHQQEAATTQLEQLH----QEAKRQEEVLARAVQEKEALVREKAA 740

Query: 110  KEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDI-- 167
             E     ++  ++ + + L   L    S  E L S   E ++ N  +E+ +G+L   I  
Sbjct: 741  LEV----RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796

Query: 168  ----KEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGL----------KHEIK 213
                KE    E R L+   + E      ++  +  +  Q E EG           + E+ 
Sbjct: 797  VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVN 856

Query: 214  RL----EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKE--------L 261
            +L    E+E  +   +L  A+   E  + +LE  L+  +TE E   + R+E        L
Sbjct: 857  QLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESAL 916

Query: 262  SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
                   +    S L   L   K   DA++                L +L  D K    K
Sbjct: 917  CQMQLETEKERVSLLETLLQTQKELADASQQ---------------LERLRQDMKVQKLK 961

Query: 322  KEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
            ++       + + +   EL  +  Q  +  L  ++ E + LL    D QKQ+E  +  L 
Sbjct: 962  EQETTGILQTQLQEAQRELKEAARQH-RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020

Query: 382  EQ-------QEKVTRLTENLSALRRLQASKERQTA------LDNEKDRDSHEDGDYYEVD 428
             Q       +++V           R+Q   ER+ A      ++ E+     ++ D     
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD----S 1076

Query: 429  INGPEILACKYHV--AVAEAGELREQLKALRSTHEAREAQHAEEKGRY--EAEGQALTE- 483
            I   E+ A +  +  A  E  EL  Q++ LR   + +EA    ++ +   E E   +TE 
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ 1136

Query: 484  --KVSLLEKASRQDRELLARLEKELKKVSDVAGETQ-GSLSVAQDELVTFSEELANLYHH 540
              + SL  + ++   +L  RL     ++  +A E Q G+ + AQ +L +    L      
Sbjct: 1137 QLRASLWAQEAKA-AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195

Query: 541  VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
            VC    E              GG    S  G   P+  G RS  L  +G L         
Sbjct: 1196 VCESRPELSG-----------GGDSAPSVWG-LEPDQNGARS--LFKRGPLLTALS---- 1237

Query: 601  GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT----------- 649
                       ++ S L    ++         ++RDQ++ L+  +  T            
Sbjct: 1238 ---------AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ 1288

Query: 650  ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL---RTVLKANKQTAEV 706
            +L RQ   +QE     +  + +L  E+++L   +++ + ++      R   +  ++  + 
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348

Query: 707  ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQR 766
            A  NL ++ E+ +A V E   +  +    L+ED  T    R+    + +E      E +R
Sbjct: 1349 AKENLTAQVEHLQAAVVEARAQA-SAAGILEEDLRT---ARSALKLKNEEV-----ESER 1399

Query: 767  QLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
            + A A  E+  L      A+Q+ LAL  +      +  +T RG+ +   K +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 128/599 (21%), Positives = 241/599 (40%), Gaps = 88/599 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKR-LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
            +E++     ++AQ E  R + +  L     ET +E++   E  L   +E      Q E L
Sbjct: 892  KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951

Query: 65   EVDYEAIRSEMEQ----LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
              D +  + + ++    L+    +A    K+ A        +L +ES+S     ++  ++
Sbjct: 952  RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS----LLQDKMD 1007

Query: 121  LQTELKQLRNVLTNTQSENERLASV--------AQELKEINQNVEIQRGRLRDDIKEYKF 172
            LQ +++ L++ L   Q +++RL            QE   I + +E ++  L   + E   
Sbjct: 1008 LQKQVEDLKSQLV-AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME--- 1063

Query: 173  REARLLQDYSELEEENISLQKQVSVLRQNQVEFEG-----------LKHEIKRLEEETEY 221
            +E RLL     L+E +   Q+++S LRQ+  E +G           L+ E+K  E +   
Sbjct: 1064 KEQRLLV----LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119

Query: 222  LNSQLEDAIRLKEISERQL---------------------EEALETLKTEREQKNSLRKE 260
              +QL + +    I+E+QL                     E  LE L  E++  N  + +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179

Query: 261  LSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE---HGGLAKLPLDNKT 317
                     S Y++ L  +L  +  S        D+   V G E   +G  +        
Sbjct: 1180 AQLA-----SLYSA-LQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233

Query: 318  STPKKEGLAPPSPSLVSDLLS-----ELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQ 372
            +    E +A     L  DL       ++   ++QKL+++L   E EK+ +   LQD Q+Q
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293

Query: 373  LEHTRGSLSEQQEKVTRLTENLSALRRLQASKE---RQTALDNEKDRDSHE----DGDYY 425
            L   +   S+ + K   L   L  L    AS +   R+  L   + +   E      +  
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL 1353

Query: 426  EVDINGPEILACKYHVAVAEAGELREQLKALRST---------HEAREAQHAEEKGRYE- 475
               +   +    +     + AG L E L+  RS           E   AQ  +E+G  + 
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413

Query: 476  AEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
            A+G+AL E ++LL +   +  E +  L  +++++       + +L +   +L   ++E+
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 175/844 (20%), Positives = 336/844 (39%), Gaps = 112/844 (13%)

Query: 28   RLSHELAETTREKIQAAE--------YGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
            +L +E  E+ RE+ QA +         G A+ E    L     E E + E +R ++++L+
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448

Query: 80   EAFGQAHTNHKKVAADGESREESL-IQESASKEQYYVRKVLE------------LQTELK 126
            +         + ++ D + R + + +Q+   +E    R VLE            L  + +
Sbjct: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
            Q+R +  + +++   L     EL++ +Q +E QRG+++D  K+    E   L    ELEE
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL----ELEE 1564

Query: 187  ENISLQKQVSVLR----QNQVEFEGLKHEIKRLEEETEYL---NSQLEDAIRLKEISERQ 239
             +  ++ Q  +++    Q + +   L H    LEE ++ L   +SQ+ D      +  R+
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE 1624

Query: 240  LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
            L+E  + +K++REQ   L+++  H ++ +       L +  + ++  +D  +     + L
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEH-LTQDLERRDQELMLQKERIQVLED--QRTRQTKIL 1681

Query: 300  VNGFEHGGLAKLPLDNKTSTPK-------KEGLAPPSPSLVS----DLLSELNISEIQKL 348
                E   L+      + +T +       +EG  P      S     L+      E++  
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741

Query: 349  KQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER-- 406
            ++ + +++  K  L   LQ   +++  T   LS++++++  L + L   R     KE+  
Sbjct: 1742 QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL 1801

Query: 407  QTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV---AVAEAGELREQLKALRSTHEAR 463
            Q+ LD  +   +  D +   +     +    +  V   A A  G L +    L+  H   
Sbjct: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861

Query: 464  EAQHAEEKGRYEAE-------GQALTEKVSLLEKASRQDRELLARL-----------EKE 505
            +  H E+  R E E        QAL E +  L   SR+  + L  L           E E
Sbjct: 1862 Q-DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920

Query: 506  LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAG 565
             + + D   + Q  L     EL     E  +  H       E   R   +  +E  G A 
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRH------QEEAARARAEALQEALGKAH 1974

Query: 566  RTSPGGRTSPEARGRRSPILLPKGLLAPEAGRAD-GGTGDSSPSPGSSLPSPLSDPRREP 624
                G       +   S  L        EA  A    + D+  +    L   L   R + 
Sbjct: 1975 AALQGKEQHLLEQAELSRSL--------EASTATLQASLDACQAHSRQLEEAL---RIQE 2023

Query: 625  MNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
              I +     ++ ++ LQ A+  R  EL  Q+   Q L  ++    + + E +++ K  L
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL---AQRVQENMIQEKQNL 2080

Query: 684  STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
              +RE+      +   ++   E+ L    ++ E E   + ET    RN L+AL     T 
Sbjct: 2081 GQEREE----EEIRGLHQSVRELQLT--LAQKEQEILELRETQQ--RNNLEALPHSHKT- 2131

Query: 744  SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
                    +  +E   +LD ++ +L   + E + L + LR    +++   ++ + L L  
Sbjct: 2132 --------SPMEEQSLKLDSLEPRL---QRELERLQAALRQTEAREIEWREKAQDLALSL 2180

Query: 804  EQTR 807
             QT+
Sbjct: 2181 AQTK 2184



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 111/545 (20%), Positives = 211/545 (38%), Gaps = 78/545 (14%)

Query: 22   LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
            L +    L  E+A+     ++ +    A+  +K  L  Q  +LE + +++ S ME  ++A
Sbjct: 580  LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639

Query: 82   FGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK-QLRNVLTNTQSENE 140
                  +     A+ E R E+L +++   E   ++K  E   EL+  LR++    Q E E
Sbjct: 640  RNALQVD----LAEAEKRREALWEKNTHLEAQ-LQKAEEAGAELQADLRDI----QEEKE 690

Query: 141  RLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQ 200
             +     E +   +    Q  +L  + K  +   AR +Q+   L  E  +L+ +      
Sbjct: 691  EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR------ 744

Query: 201  NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKE 260
                       ++ +E + + L  QL+     KE+ E  L EA +        K  L  +
Sbjct: 745  -----------LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793

Query: 261  LSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTP 320
            +       +        + L+ L      AE   DA A         LA+   + KT+  
Sbjct: 794  IQTVTQAKEVIQGEVRCLKLE-LDTERSQAEQERDAAA-------RQLAQAEQEGKTALE 845

Query: 321  KKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
            +++       + + +   +      Q+L + L  +EREK  L   L++ Q ++E    ++
Sbjct: 846  QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME----AI 901

Query: 381  SEQQEKVTRLTENLSALRRLQASKER----QTALDNEKDRDSHEDGDYYEVDINGPEILA 436
              Q+E+     E+     +L+  KER    +T L  +K                      
Sbjct: 902  QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK---------------------- 939

Query: 437  CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDR 496
                    E  +  +QL+ LR   + ++ +  E  G  + +   L E    L++A+RQ R
Sbjct: 940  --------ELADASQQLERLRQDMKVQKLKEQETTGILQTQ---LQEAQRELKEAARQHR 988

Query: 497  ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETP--NRVML 554
            + LA L++E   +     + Q  +   + +LV   +    +   V     ET   NR+  
Sbjct: 989  DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048

Query: 555  DYYRE 559
            +  RE
Sbjct: 1049 ELERE 1053



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 160/764 (20%), Positives = 285/764 (37%), Gaps = 114/764 (14%)

Query: 90  KKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL 149
           +++  +   R + LIQ    K Q  + K  ELQ  + +L  +LT +Q +NE    + + L
Sbjct: 254 QELEKEAHERSQELIQ---LKSQGDLEKA-ELQDRVTELSALLTQSQKQNEDYEKMIKAL 309

Query: 150 KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLK 209
           +E  + +E     L +        EA L ++    +EE +SLQ+ +  + Q  VE     
Sbjct: 310 RETVEILETNHTELME-------HEASLSRN---AQEEKLSLQQVIKDITQVMVE----- 354

Query: 210 HEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL----ETLKTEREQKNSLRKELSHYM 265
            E   + + + + NS   D+    +   +  ++AL      L   R+    LR++L+   
Sbjct: 355 -EGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413

Query: 266 SINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGL 325
              +     H     +G        +   + + L           + L  +  +  KE  
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG-------QTVDLQGEVDSLSKE-- 464

Query: 326 APPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
                        EL     ++L+QQL  +E+E   L     + Q Q +  +G   EQQE
Sbjct: 465 ------------RELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512

Query: 386 KV-------TRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACK 438
           ++        RL E L  L   Q+    +     E    SH +G+    +         +
Sbjct: 513 ELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572

Query: 439 YHVAVA-----------EAGELREQLKALRSTHEA--------------REAQHAEEKGR 473
              ++A           E  +LR     L + +EA               E ++     R
Sbjct: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632

Query: 474 YEAEGQALTE-KVSLLEKASRQDR--ELLARLEKELKKVSDVAGETQGSLSVAQDELVTF 530
            EA  QA    +V L E   R++   E    LE +L+K  +   E Q  L   Q+E    
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692

Query: 531 SEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGR-RSPILLPKG 589
            ++L+   H       E     +   ++E +    +     R   E     R    L   
Sbjct: 693 QKKLSESRH-----QQEAATTQLEQLHQEAK---RQEEVLARAVQEKEALVREKAALEVR 744

Query: 590 LLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
           L A E  R D        S    L   L     E     ++I + + Q++     V +  
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKEL---LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801

Query: 650 ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALA 709
           E+ +  +   +L    ++  +A  E     + L   ++E     +T L+  K   E  + 
Sbjct: 802 EVIQGEVRCLKLELDTER-SQAEQERDAAARQLAQAEQEG----KTALEQQKAAHEKEVN 856

Query: 710 NLKSKYENEK-------AMVTETMMKLRNELK-ALKEDAATFSSLRAMFATRCDEYITQL 761
            L+ K+E E+       A   E++ + + EL+  LKE      +++A    + +E  TQ 
Sbjct: 857 QLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA----QREEERTQA 912

Query: 762 DE--MQRQLAAAEDEKKTLNSLLRMAIQQKLA-LTQRLELLELD 802
           +    Q QL   ++    L +LL+   Q++LA  +Q+LE L  D
Sbjct: 913 ESALCQMQLETEKERVSLLETLLQ--TQKELADASQQLERLRQD 954



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 136/590 (23%), Positives = 229/590 (38%), Gaps = 131/590 (22%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLS------HELAETTREKIQAAEYGLAVLEEKHQ--- 56
            +E E  R V+E  P  ++   ++L+       EL +    +    E+ L  LE+K Q   
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539

Query: 57   --------LKLQFE-------ELEVDYEAIRSEMEQLKEAFGQAHTNH---KKVAADGES 98
                    LK Q         ELE ++  +  + + +KE  GQ  T       +  D E 
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEE 1599

Query: 99   REESLIQESA------SKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVA----QE 148
            R + L  +S+      S      R++ E   E+K  R  +   Q + E L        QE
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659

Query: 149  L---KEINQNVEIQRGR----LRDDIKEYKFR----------EARLLQDYSE-----LEE 186
            L   KE  Q +E QR R    L +D+++ K            + +L+Q+ +E      + 
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719

Query: 187  ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET 246
            +  SL+    +LR  + E E  +  I  L+E  + L  QL+   R  ++ E  L      
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHR--KVGETSL------ 1771

Query: 247  LKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
            L ++REQ+  + +                                     + L    E G
Sbjct: 1772 LLSQREQEIVVLQ-------------------------------------QQLQEAREQG 1794

Query: 307  GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
             L +  L ++    ++  LA     L      E    E Q+ + Q  +++ +   L   L
Sbjct: 1795 ELKEQSLQSQLDEAQR-ALAQRDQEL------EALQQEQQQAQGQEERVKEKADALQGAL 1847

Query: 367  QDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE-----RQTALDNEK-----D 415
            +     L+   G L + +E+  RL E L+   RR+QA +E     R  + + EK      
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907

Query: 416  RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYE 475
            +   E    +EV+      L   +  A A   E  ++L+ALR+  E++ ++H EE  R  
Sbjct: 1908 QQCAEQAQEHEVETRA---LQDSWLQAQAVLKERDQELEALRA--ESQSSRHQEEAARAR 1962

Query: 476  AEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGET-QGSLSVAQ 524
            AE  AL E +     A+ Q +E     + EL +  + +  T Q SL   Q
Sbjct: 1963 AE--ALQEALGKAH-AALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 122/544 (22%), Positives = 206/544 (37%), Gaps = 128/544 (23%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ---- 56
            + A S E+E A L ++ Q        +   HE+   TR    +     AVL+E+ Q    
Sbjct: 1892 LRAESREQEKALLALQQQ-----CAEQAQEHEVE--TRALQDSWLQAQAVLKERDQELEA 1944

Query: 57   LKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVR 116
            L+ + +      EA R+  E L+EA G+AH       A  + +E+ L++           
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAH-------AALQGKEQHLLE----------- 1986

Query: 117  KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREAR 176
                 Q EL   R++  +T +    L +     +++ + + IQ G ++D    Y+    +
Sbjct: 1987 -----QAELS--RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039

Query: 177  LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS 236
            L Q  ++ +EE                    L+H+    +E  + L   L   ++   I 
Sbjct: 2040 LQQALAQRDEE--------------------LRHQ----QEREQLLEKSLAQRVQENMIQ 2075

Query: 237  ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
            E+Q       L  ERE++                     LH S+  L+ +   A+   + 
Sbjct: 2076 EKQ------NLGQEREEEE-----------------IRGLHQSVRELQLT--LAQKEQEI 2110

Query: 297  EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQME 356
              L    +   L  LP  +KTS  +++       SL  D L      E+++L+  L Q E
Sbjct: 2111 LELRETQQRNNLEALPHSHKTSPMEEQ-------SLKLDSLEPRLQRELERLQAALRQTE 2163

Query: 357  REKAGLLATLQDTQKQLEHTRGSLSEQQEKV----TRLTENLSALRRLQASKE-RQTALD 411
              +       QD    L  T+ S+S  QE        + E  S  +RLQ   E  + AL+
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223

Query: 412  NEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR--STHEAREAQHAE 469
             E+    H  G                   + AE G   EQ   L   S  EA  +    
Sbjct: 2224 KER---LHSPG-----------------ATSTAELGSRGEQGVQLGEVSGVEAEPSPDGM 2263

Query: 470  EKGRYEAEGQALTEKV-------SLLEKASRQDRELLARLEKELKKVSDVA--GETQGSL 520
            EK  +    + L + V       S L++ + Q R  L ++E+E +K+   A      GSL
Sbjct: 2264 EKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSL 2323

Query: 521  SVAQ 524
             +++
Sbjct: 2324 EISK 2327



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 28/120 (23%), Positives = 56/120 (46%), Gaps = 13/120 (10%)

Query: 622 REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKS 681
           REP  +  L+A  ++  K    A +R+ EL        +L    D +K  L + + +L +
Sbjct: 241 REPAQLLLLLAKTQELEKE---AHERSQELI-------QLKSQGDLEKAELQDRVTELSA 290

Query: 682 LLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM---VTETMMKLRNELKALKE 738
           LL+  ++Q      ++KA ++T E+   N     E+E ++     E  + L+  +K + +
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 173/858 (20%), Positives = 346/858 (40%), Gaps = 115/858 (13%)

Query: 16   EAQPEWLRAEV---KRLSHELAETT--REKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
            +A  EWL  +    K LS  L +     EK +  +  L+ LEE H  +LQ    +   E 
Sbjct: 350  KATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE-HLSQLQDNPPQEKGEV 408

Query: 71   IRS--EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
            +    ++E LK+       N+ ++ A    R E L  E   +E   + +    + E +QL
Sbjct: 409  LGDVLQLETLKQEAATLAANNTQLQA----RVEMLETERGQQEAKLLAERGHFEEEKQQL 464

Query: 129  RNVLTNTQSENERLASVAQELKEINQ----NVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
             +++T+ QS    L+   +EL++ +Q     +  Q   L  ++        +  Q+ + L
Sbjct: 465  SSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL 524

Query: 185  EEENISLQKQVS-VLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
            +++    Q Q++  L+Q +   +GL+H++++L    +    QL++    +E + +   + 
Sbjct: 525  KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584

Query: 244  LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
            L T   ERE     R      +   +    + L +    L+ +++A +    +       
Sbjct: 585  LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQR- 643

Query: 304  EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
            E   L++   + +            + + V++L  EL +   Q+   +  ++ +EK  L 
Sbjct: 644  EKAELSRKVEELQACVETARQEQHEAQAQVAEL--ELQLRSEQQKATEKERVAQEKDQLQ 701

Query: 364  ATLQDTQKQLEHTRGSLSEQQ-------EKVTRLTENLSALRRLQASKERQTALDNEKDR 416
              LQ  ++ L+ T+GSL E++       E+  R    L A  R    + ++   + E++R
Sbjct: 702  EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761

Query: 417  DSHE----------DGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKALRSTHEARE 464
               +          +    E ++   E+       H A +E  +L +++ A R  +E  +
Sbjct: 762  AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821

Query: 465  AQHA--------------EEKGRYEAEGQALTEKVSLLE-----KASRQDREL------L 499
             + A              EE  +   E Q   EKV+ +E     + SRQ  EL      L
Sbjct: 822  QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL 881

Query: 500  ARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMC--NNETPNRVMLDYY 557
            AR  +++++    A +    LS  Q+++   S+E+A L   V       ET +R ++   
Sbjct: 882  ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV--- 938

Query: 558  REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
                             P   G R P  L +     + GR              S  + L
Sbjct: 939  ---------------KEPARAGDRQPEWLEE-----QQGR-----------QFCSTQAAL 967

Query: 618  SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPA---VDKDKEAL 672
                RE   + N +  +R  +   Q           + +A  +QE G A   +  +K A 
Sbjct: 968  QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027

Query: 673  MEEILKLKSLLSTKREQITTLRTVL------KANKQTAEVALANLKSKYENEKAMVTETM 726
             E  ++L++ L+ +R +  TL+  L      K  K      L  L++    E   + +T+
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087

Query: 727  MKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED----EKKTLNSLL 782
             +L+ +L   +++ A+ S  ++  A R +    +L+ ++ +++  E     +++  +SL 
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147

Query: 783  RMAIQQKLALTQRLELLE 800
            R    ++ +  +R   LE
Sbjct: 1148 RSLEAERASRAERDSALE 1165



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 170/854 (19%), Positives = 339/854 (39%), Gaps = 148/854 (17%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREK-----------IQAAEYGLAVLEEK 54
            +++E A   +  Q E L + +K+   +L E   ++             AAE   A L E+
Sbjct: 540  QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER 599

Query: 55   HQLKLQFEELEVD----YEAIRSEMEQLKEAFGQAHTN-----HKKVAADGESREESLIQ 105
                 Q E LE +     E ++ +++   EA   A T+      +K     +  E     
Sbjct: 600  DAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACV 659

Query: 106  ESASKEQYYVR-KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR 164
            E+A +EQ+  + +V EL+ +L+  +   T  +   +    + ++L+ + +++++ +G L 
Sbjct: 660  ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719

Query: 165  DDIKEYKFREARLLQDY----SELEEENISL----QKQVSVLRQNQVEFEGLKHEIKRLE 216
            ++    K R A  L++     SEL+ E  SL    +++   L + +   +GL+  +++L 
Sbjct: 720  EE----KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG 775

Query: 217  E----ETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFY 272
            E    ETE L  +L +A+  +  +E + E+ ++ +   RE+    ++E + Y        
Sbjct: 776  EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY-------- 827

Query: 273  TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
                     G  F +       + E            K   + + +  K  G+       
Sbjct: 828  ---------GAMFQEQLMTLKEECE------------KARQELQEAKEKVAGI------- 859

Query: 333  VSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTE 392
              +  SEL IS  Q    +L ++    A  L  +Q+ + + +     LS  QEK+   ++
Sbjct: 860  --ESHSELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914

Query: 393  NLSALRRL--QASKERQTA---LDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA--- 444
             ++ L  L  +A ++++TA   L  E  R      ++ E +  G +   C    A+    
Sbjct: 915  EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE-EQQGRQF--CSTQAALQAME 971

Query: 445  -EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLE 503
             EA ++  +L+ LR+     + Q  EE+G+ E E   LT++    +     ++   A LE
Sbjct: 972  REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELE 1031

Query: 504  KELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGG 563
              L          Q +L+  + E  T  E LA+                + +   + Q  
Sbjct: 1032 MRL----------QNALNEQRVEFATLQEALAH---------------ALTEKEGKDQEL 1066

Query: 564  AGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE 623
            A           E    R  +   K  LA +      G+G  S + G + P+    P+ E
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT---GPKLE 1123

Query: 624  PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
             +         R ++  L+    +  E +     S E   A   ++++ +E    L+  L
Sbjct: 1124 AL---------RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET---LQGQL 1171

Query: 684  STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
              K +++   ++ L +    A+  LA  ++K ++      E   ++    +  +   +  
Sbjct: 1172 EEKAQELGHSQSALAS----AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI 1227

Query: 744  SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
            SSL             ++  + RQ+   E E K L  L+    ++   L +RL LL+   
Sbjct: 1228 SSLEE-----------EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ--- 1273

Query: 804  EQTRRGRAKAAPKT 817
             +T    A+AA ++
Sbjct: 1274 AETASNSARAAERS 1287



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 132/525 (25%), Positives = 229/525 (43%), Gaps = 64/525 (12%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
            E LR  VK+L  +LA+  +EK  A+  G      + +   + E      EA+R+E+ +L+
Sbjct: 1081 EELRQTVKQLKEQLAK--KEKEHASGSGA-----QSEAAGRTEPTGPKLEALRAEVSKLE 1133

Query: 80   EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE-LQTELKQLRNVLTNTQSE 138
            +         +K     +S E SL  E AS+ +      LE LQ +L++    L ++QS 
Sbjct: 1134 QQC-------QKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSA 1184

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
               LAS  +EL      V+    +  D   E+K + AR  Q+         SL+++VS+L
Sbjct: 1185 ---LASAQRELAAFRTKVQ-DHSKAED---EWKAQVARGRQEAERKNSLISSLEEEVSIL 1237

Query: 199  RQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEI-SERQLEEALETLKTEREQKNSL 257
             +  +E EG   E+KRL       + +LE+ +RL +  +      A E     RE+  SL
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297

Query: 258  RKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF--EHGGLAKLPLDN 315
            R+E       ++       ++  +    ++ A E   + +A    F  +   L+ L L++
Sbjct: 1298 REEAEKQRVASE-------NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350

Query: 316  KTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEH 375
             TST        P+  L   L +E   +E ++ +++L Q ++   GL A L   Q++L  
Sbjct: 1351 -TSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSKQAAGGLRAELLRAQREL-- 1406

Query: 376  TRGSLSEQQEKVTRLTENLSALRRLQASKERQTA-------LDNEKDRDSHEDGD----Y 424
              G L   ++KV         LR  +AS   Q +       L  E++R   E  +    +
Sbjct: 1407 --GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQF 1464

Query: 425  YEVDINGPEILACKYHVAVAEAGELR------------EQLKALRSTHEAREAQHAEEKG 472
             EV+++       +   AV    E R             +L+ + + +E  + +  EE+ 
Sbjct: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524

Query: 473  RYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ 517
            R++ E Q LT +V  LE   R+  + +  L K+L   SD A + Q
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD-SDQASKVQ 1568



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 146/741 (19%), Positives = 290/741 (39%), Gaps = 81/741 (10%)

Query: 90  KKVAADGESREESLIQESASKEQYYVRK---VLELQTELKQLRNVLTNTQSENERLASVA 146
           KK  AD  S  + L  E A   +    K   +  +Q  + +L  +L   Q+ +       
Sbjct: 220 KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKEL 278

Query: 147 QELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE 206
           +EL++ N+++ ++        ++ K  ++++ +  ++L EEN  L  ++     +  + +
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338

Query: 207 GLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS---- 262
              +E+   EE ++     LE   +L    E++L  AL+  K   E+   L+ +LS    
Sbjct: 339 DALNELT--EEHSKATQEWLEKQAQL----EKELSAALQDKKCLEEKNEILQGKLSQLEE 392

Query: 263 HYMSINDSFYTSHLHVSLDGLKFSD------DAAEPNNDAEALVNGFEHGG---LAKLPL 313
           H   + D+       V  D L+           A  N   +A V   E       AKL  
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452

Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK-AGLLATLQDTQKQ 372
           +      +K+ L+    SL++DL S  +IS + + K++L Q  +   A L A +     +
Sbjct: 453 ERGHFEEEKQQLS----SLITDLQS--SISNLSQAKEELEQASQAHGARLTAQVASLTSE 506

Query: 373 LEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE-KDRDSHEDGDYYEVDING 431
           L     ++ +Q +++  L          Q +KE+Q  L    + ++    G  ++V    
Sbjct: 507 LTTLNATIQQQDQELAGLK---------QQAKEKQAQLAQTLQQQEQASQGLRHQV---- 553

Query: 432 PEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKA 491
            E L+        +  E+ E+ +A R  H  + A  AEE+     E  A  +++  LEK 
Sbjct: 554 -EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612

Query: 492 SRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPN- 550
                E+   L+++L+  ++     Q S++ AQ E    S ++  L   V     E    
Sbjct: 613 KAAKLEI---LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669

Query: 551 -----RVMLDYYREGQGGAGR---TSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
                 + L    E Q    +        +   + +  +  + + KG L  E  RA    
Sbjct: 670 QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL 729

Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS--QE 660
            +            +S+ + E  ++       R +++  +A         R+ + +  Q+
Sbjct: 730 EEQQRC--------ISELKAETRSLVEQHKRERKELEEERA--------GRKGLEARLQQ 773

Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKR---EQITTLRTVLKANKQTAEVALANLKSKYEN 717
           LG A   + E L  E+ +  +   T     EQ+       +   + ++   A   + ++ 
Sbjct: 774 LGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE 833

Query: 718 EKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLD-EMQRQLAAAEDEKK 776
           +   + E   K R EL+  KE  A   S   +  +R    + +L   + R L   ++++ 
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893

Query: 777 TLNSLL--RMAIQQKLALTQR 795
               L      +Q+K+A T +
Sbjct: 894 RAQKLADDLSTLQEKMAATSK 914



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 113/532 (21%), Positives = 208/532 (39%), Gaps = 81/532 (15%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELE 65
            E +E  RLVM A+ E  +   +RL    AET     +AAE   A+ EE   L+ + E+  
Sbjct: 1247 ESKELKRLVM-AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305

Query: 66   VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTEL 125
            V  E +R E+    E                  R E L QE  + ++ + +K   L T  
Sbjct: 1306 VASENLRQELTSQAE------------------RAEELGQELKAWQEKFFQKEQALST-- 1345

Query: 126  KQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELE 185
              L+   T+TQ+    L       +++         R R+++++ K       Q    L 
Sbjct: 1346 --LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK-------QAAGGLR 1396

Query: 186  EENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALE 245
             E +  Q+++        E   L+ ++   E   + L ++           +    E L 
Sbjct: 1397 AELLRAQRELG-------ELIPLRQKVAEQERTAQQLRAE-----------KASYAEQLS 1438

Query: 246  TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSDDAAEPNNDAEALVNGF 303
             LK    + + L  E +  +    +     L V LD    K+  + A    DAE      
Sbjct: 1439 MLK----KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET----- 1489

Query: 304  EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN--ISEIQKLKQQLMQMEREKAG 361
                LA++  + +++  + E +          +L E      E QKL  Q+ Q+E  +  
Sbjct: 1490 ---RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546

Query: 362  LLATLQDTQKQLEHTRGSLSEQQEKVTRLT----ENLSALRRLQASKERQTALDNEKDRD 417
                +++  K+L  +  +   QQ+K+  +     E+    +RLQA      A  ++K+  
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE-- 1604

Query: 418  SHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAE 477
              +  ++Y++ +   E     Y     +  EL+EQL++L    E  + ++ E +   E  
Sbjct: 1605 --QAAEHYKLQM---EKAKTHYDAKKQQNQELQEQLRSL----EQLQKENKELRAEAERL 1655

Query: 478  GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ--GSLSVAQDEL 527
            G  L +     ++A +  R L A++     +V+    + +  G   VA D L
Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 51/292 (17%)

Query: 7    EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
            E   A +  EAQ      EV    +E A     K++  E      EE+ +L  Q E+LEV
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGA-----KVKVLEERQRFQEERQKLTAQVEQLEV 1542

Query: 67   DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
                   ++E+L           KK+A            + ASK Q         Q +LK
Sbjct: 1543 FQREQTKQVEELS----------KKLADS----------DQASKVQ---------QQKLK 1573

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
             ++     +Q E +RL +   EL       + Q  +     + YK +  +    Y   ++
Sbjct: 1574 AVQAQGGESQQEAQRLQAQLNEL-------QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626

Query: 187  ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET 246
            +N  LQ+Q+  L Q Q E + L+ E +RL  E +    + ++A    E + R L   + +
Sbjct: 1627 QNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA----EQTCRHLTAQVRS 1682

Query: 247  LKTEREQKNSLRKELSHYMSINDSFYT------SHLHVSLDGLKFSDDAAEP 292
            L+ +    +   ++L  +    D+  +        L +S+D L  S +   P
Sbjct: 1683 LEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTP 1734



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 41/171 (23%), Positives = 71/171 (41%), Gaps = 15/171 (8%)

Query: 634 IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
           +R+   HLQ   D   EL+ +   + +         E  +   L+ K  L  K E     
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE----- 381

Query: 694 RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATR 753
             +L+      E  L+ L+     EK  V   ++    +L+ LK++AAT ++       R
Sbjct: 382 --ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL----QLETLKQEAATLAANNTQLQAR 435

Query: 754 CDEYITQLDEMQRQLAAA----EDEKKTLNSLLRMAIQQKLALTQRLELLE 800
            +   T+  + + +L A     E+EK+ L+SL+         L+Q  E LE
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 178/846 (21%), Positives = 330/846 (39%), Gaps = 123/846 (14%)

Query: 25   EVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQ 84
            +V R   EL     E ++  E    V  E  +++ + ++L  +   +  +++   E F +
Sbjct: 846  QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905

Query: 85   AHTNHKKVAADGESREESL------IQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
            A     ++AA  +  EE L      ++E   + Q    +  ++Q  ++ L   L   +  
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965

Query: 139  NERL----ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
             ++L     +   ++K++ + + +   +    IKE K  E R+ +  S+L EE    +  
Sbjct: 966  RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025

Query: 195  VSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQ- 253
              +  + +V    L+  +K+ EE+T     +LE A R  +     L++ +  L+ + ++ 
Sbjct: 1026 AKIRNKQEVMISDLEERLKK-EEKTR---QELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081

Query: 254  KNSLRK---ELSHYMSINDSFYTSHLHVSLDGLK-FSDDAAEPNNDAEALVNGFEHGGLA 309
            K  L K   EL   ++  D   T H + +L  ++      AE   D E+           
Sbjct: 1082 KLQLAKKEEELQGALARGDD-ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140

Query: 310  KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDT 369
            K  L  +    K E       +     L      E+ +LK+ L   E E     A +QD 
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL---EEETKNHEAQIQDM 1197

Query: 370  QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
            +++       LSEQ E+  R   NL         K +Q    + K+              
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLE--------KNKQGLETDNKE-------------- 1235

Query: 430  NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE 489
                 LAC+  V         +Q+KA        E++H  +K   +A+ Q L  KVS  +
Sbjct: 1236 -----LACEVKVL--------QQVKA--------ESEHKRKK--LDAQVQELHAKVSEGD 1272

Query: 490  KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC----MCN 545
            +   +  E  ++L+ EL  VS +  E       A+ + + F+++ A+L   +     +  
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEE-------AEKKGIKFAKDAASLESQLQDTQELLQ 1325

Query: 546  NETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG----- 600
             ET  ++ L   R  Q    + S   +   E   R++   L K +LA ++  AD      
Sbjct: 1326 EETRQKLNLSS-RIRQLEEEKNSLQEQQEEEEEARKN---LEKQVLALQSQLADTKKKVD 1381

Query: 601  ---GTGDSSPSPGSSL---PSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ 654
               GT +S       L      LS    E    Y+ +   +++++  Q   D T +L  Q
Sbjct: 1382 DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ--QELDDLTVDLDHQ 1439

Query: 655  RIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANL--- 711
            R  +  L     K  + L EE    KS+ +   E+        +  K+T  ++LA     
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEE----KSISARYAEERDRAEAEAR-EKETKALSLARALEE 1494

Query: 712  ----KSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQ 767
                K ++E +   +   M  L +    + ++       +     + +E  TQL+E++ +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554

Query: 768  LAAAEDEKKTLN-SLLRMAIQ--------------QKLALTQRLELLELDHEQTRRGRAK 812
            L A ED K  L  ++  M  Q              +K  L +++  LE + E  R+ RA 
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614

Query: 813  AAPKTK 818
            A    K
Sbjct: 1615 AVASKK 1620



 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 171/836 (20%), Positives = 334/836 (39%), Gaps = 137/836 (16%)

Query: 5    SEEEEYAR---LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
            +EEEE A+    +   Q   +    +RL  E  E TR++++ A+  L    E   L+ Q 
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKE--EKTRQELEKAKRKLD--GETTDLQDQI 1071

Query: 62   EELEVDYEAIRSEMEQLKE------AFGQAHTNHK----KVAADGESR----EESLIQES 107
             EL+   + ++ ++ + +E      A G   T HK    KV  + +++    +E    E 
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 108  ASKEQYYVRKVLELQTELK----QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRL 163
            AS+ +   +K  +L  EL+    +L + L  T ++ E      QE+ E+ + +E +    
Sbjct: 1132 ASRNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 164  RDDIKEYKFREARLLQDYSE------------------LEEENISLQKQVSVLRQNQVEF 205
               I++ + R A  L++ SE                  LE +N  L  +V VL+Q + E 
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 206  EGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYM 265
            E   H+ K+L+ + + L++++ +  RL+     +L E    L+ E +  ++L +E     
Sbjct: 1251 E---HKRKKLDAQVQELHAKVSEGDRLRV----ELAEKASKLQNELDNVSTLLEEAEK-- 1301

Query: 266  SINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGL 325
                            G+KF+ DAA   +  +      +     KL L ++    ++E  
Sbjct: 1302 ---------------KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE-- 1344

Query: 326  APPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
                     + L E    E +  K     +E++   L + L DT+K+++   G++   +E
Sbjct: 1345 --------KNSLQEQQEEEEEARKN----LEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 386  KVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
               +L ++  AL +RL+        L+  K+R   E  D   VD++    +A        
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL-TVDLDHQRQVASNLEKKQK 1451

Query: 445  EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
            +  +L  + K++        A++AEE+ R EAE +    K   L +A          LE+
Sbjct: 1452 KFDQLLAEEKSI-------SARYAEERDRAEAEAREKETKALSLARA----------LEE 1494

Query: 505  ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
             L+   +   + +  L    ++L++  +++    H +     E   R +     E +   
Sbjct: 1495 ALEAKEEFERQNK-QLRADMEDLMSSKDDVGKNVHEL-----EKSKRALEQQVEEMRTQL 1548

Query: 565  GRTSPGGRTSPEARGRRSPILLPKGLLAPEAG-RADGGTGDSSPSPGSSLPSPLSDPRRE 623
                   + + +A+ R     L   + A +A    D  T D        L          
Sbjct: 1549 EELEDELQATEDAKLR-----LEVNMQAMKAQFERDLQTRDEQNEEKKRL---------- 1593

Query: 624  PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
                      +  Q++ L+A ++   +     +AS++      KD EA +E   K +  +
Sbjct: 1594 ----------LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643

Query: 684  STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
                +Q+  L+  +K  ++  E A A+    +   K    + +  L  E+  L+E+ A+ 
Sbjct: 1644 I---KQLRKLQAQMKDYQRELEEARASRDEIFAQSKES-EKKLKSLEAEILQLQEELASS 1699

Query: 744  SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELL 799
               R       DE   ++       +A  DEK+ L + +    ++       +ELL
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 184/833 (22%), Positives = 323/833 (38%), Gaps = 101/833 (12%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELE 65
            E E+ +R   E Q   L  E++ L  EL +T        E      +E  +LK   EE  
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187

Query: 66   VDYEAIRSEM--------EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRK 117
             ++EA   +M        E+L E   QA    K+  A+ E  ++ L  E+ +K       
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQA----KRFKANLEKNKQGL--ETDNK------- 1234

Query: 118  VLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-RLRDDIKEYKFREAR 176
              EL  E+K L+ V   ++ + ++L +  QEL     + ++  G RLR ++ E   +   
Sbjct: 1235 --ELACEVKVLQQVKAESEHKRKKLDAQVQEL-----HAKVSEGDRLRVELAEKASKLQN 1287

Query: 177  LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS 236
             L + S L EE    +K+     ++    E       +L++  E L  +    + L    
Sbjct: 1288 ELDNVSTLLEE---AEKKGIKFAKDAASLE------SQLQDTQELLQEETRQKLNLSS-R 1337

Query: 237  ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN--- 293
             RQLEE   +L+ ++E++   RK L   +    S          D L   +   E     
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 294  -NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQ 351
              DAEAL    E   LA   L+       K  L      L  DL  +  + S ++K +++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEK-----TKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452

Query: 352  LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE------ 405
              Q+  E+  + A   + + + E      +E +EK T+      AL     +KE      
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAE------AEAREKETKALSLARALEEALEAKEEFERQN 1506

Query: 406  RQTALDNEKDRDSHED--GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR 463
            +Q   D E    S +D   + +E++      L  +      +  EL ++L+A        
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELE-KSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565

Query: 464  EAQHAEEKGRYEAEGQALTEKVSLLEK-ASRQDRELLARLEKELK-KVSDVAGETQGSLS 521
            E      K ++E + Q   E+    ++   +Q REL A LE E K +   VA + +  + 
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625

Query: 522  VAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYRE-GQGGAGRTSPGGRTSPEARGR 580
            +   E      E AN      +         M DY RE  +  A R     ++    +  
Sbjct: 1626 LKDLEA---QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682

Query: 581  RS----PILLPKGLLAPEAGRADG-----GTGDSSPSPGSSLPSPLSDPRREPMNIYNLI 631
            +S     + L + L + E  R           D   +  S   + L + RR    I  L 
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742

Query: 632  AIIRDQIKHLQAAVDR-----------TTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
              + ++  +++   DR             EL+ +R A+Q+     D  ++ L  +  +LK
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK----SDNARQQLERQNKELK 1798

Query: 681  SLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDA 740
            + L   +E    +++  KA     E  +  L+ + E E          +R   K LKE  
Sbjct: 1799 AKL---QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855

Query: 741  ATFSSLRA---MFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
                  R     +  + ++   ++ +++RQL  AE+E    N+  R  +Q++L
Sbjct: 1856 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA-SRRKLQREL 1907



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 89/435 (20%), Positives = 190/435 (43%), Gaps = 37/435 (8%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
            +EA+ E+ R   K+L  ++ +    K    +    + + K  L+ Q EE+    E +  E
Sbjct: 1496 LEAKEEFERQN-KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554

Query: 75   MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTN 134
            ++  ++A  +   N + + A  E   ++  +++  K++  +++V EL+ EL+  R     
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614

Query: 135  TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
              +  +++     +LK++   +E       + IK+ +  +A++     ELEE   S  + 
Sbjct: 1615 AVASKKKMEI---DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671

Query: 195  VSVLRQNQVEFEGLKHEIKRLEEE----------TEYLNSQLEDAIRLKEISERQLEEAL 244
             +  ++++ + + L+ EI +L+EE           E    +L D I      +  L +  
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731

Query: 245  ETLKTEREQ-KNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDD--AAEPNNDAEALVN 301
              L+    Q +  L +E S+   +ND F  + L V     + + +  AA+ +++A     
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR---- 1787

Query: 302  GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
                    +L   NK    K + L     S     +S L  ++I +L++QL Q  +E+A 
Sbjct: 1788 -------QQLERQNKELKAKLQELEGAVKSKFKATISALE-AKIGQLEEQLEQEAKERAA 1839

Query: 362  LLATLQDTQK-------QLEHTRGSLSEQQEKVTRLTENLSALRR-LQASKERQTALDNE 413
                ++ T+K       Q+E  R    + +E++ +    +  L+R L+ ++E  T  +  
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899

Query: 414  KDRDSHEDGDYYEVD 428
            + +   E  D  E +
Sbjct: 1900 RRKLQRELDDATEAN 1914



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 65/266 (24%), Positives = 115/266 (43%), Gaps = 53/266 (19%)

Query: 22   LRAEVKRLSHELAETTREKIQA--------------AEYGLAVLEEKHQLKLQFEELEVD 67
            L AE+ +L  ELA + R +  A              A    A+L+EK +L+ +  +LE +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744

Query: 68   YEAIRSEMEQLKEAFG----QAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
             E  +S ME L + F     Q  T + ++AA     E S  Q+S +  Q   R+  EL+ 
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAA-----ERSAAQKSDNARQQLERQNKELKA 1799

Query: 124  ELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSE 183
            +L++L               +V  + K     +E + G+L          E +L Q+  E
Sbjct: 1800 KLQELEG-------------AVKSKFKATISALEAKIGQL----------EEQLEQEAKE 1836

Query: 184  LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
                N  +++    L++  ++ E  +    + +E+ E  N+      R+K++ +RQLEEA
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA------RMKQL-KRQLEEA 1889

Query: 244  LETLKTEREQKNSLRKELSHYMSIND 269
             E        +  L++EL      N+
Sbjct: 1890 EEEATRANASRRKLQRELDDATEANE 1915


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 181/864 (20%), Positives = 336/864 (38%), Gaps = 123/864 (14%)

Query: 15   MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ---------------LKL 59
            +EA+  W +  +   +++  +T  E   A     + L+ +H+               LK 
Sbjct: 721  IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780

Query: 60   QFEELEVDY----EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYV 115
              E+++ D+    + + S +E+ K+       N K++  +      S +QE   K    +
Sbjct: 781  NIEQMDTDHKETKDVLSSSLEEQKQL--TQLINKKEIFIEKLKERSSKLQEELDKYSQAL 838

Query: 116  RKVLELQTELKQLRNVLTNTQSENERLASVAQELK-EINQNVEIQRGRLRDDIKEYKFRE 174
            RK   L+  +++    L + + EN  L    + L+ E ++   +   +  D + E     
Sbjct: 839  RKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV 898

Query: 175  ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE 234
            ++L      LEEE    QK +    Q++++      E K+  +E  Y + Q+ +A   + 
Sbjct: 899  SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM-NATHTQL 957

Query: 235  ISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNN 294
              E+  EE     KT  + K  L +E     + N   +      SL+             
Sbjct: 958  FLEKD-EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLN------------- 1003

Query: 295  DAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQ 354
                + NG E   L+K   +      K+         L   LL+E NIS    L +Q+ Q
Sbjct: 1004 ----IENGSEKHDLSKAETERLVKGIKER-------ELEIKLLNEKNIS----LTKQIDQ 1048

Query: 355  MEREKAGLLATL---QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALD 411
            + +++ G L  +   +D + Q  H R S +   + V  L + L A       +E+  A+ 
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQA---YAMEREKVFAVL 1105

Query: 412  NEKDRD-SHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEE 470
            NEK R+ SH   +Y+++     +I+A K    +    E ++      S+ +    +  + 
Sbjct: 1106 NEKTRENSHLKTEYHKM----MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQN 1161

Query: 471  KGRY----EAEGQALTEKVSLLEKA--------------SRQDRELLA---RLEKELKKV 509
              R     + E  AL++K   L                 S Q  ELL    +L++++KK+
Sbjct: 1162 LSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM 1221

Query: 510  SDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDY------YRE---- 559
             +   +   ++   Q E     EEL  L   V + +++  +++ +DY      Y +    
Sbjct: 1222 EEWKQQVMTTVQNMQHESAQLQEELHQLQAQV-LVDSDNNSKLQVDYTGLIQSYEQNETK 1280

Query: 560  ----GQGGAGRTSPGGR---TSPEARGRR---SPILLPKGLLAPEAGRADGGTGDSSPSP 609
                GQ  A      G+   T     G+    SP L    LL P++      +     S 
Sbjct: 1281 LKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSE 1340

Query: 610  GSS-LPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKD 668
             S  L   L + R+        I  +++    L  ++  T+EL R+     +      K+
Sbjct: 1341 SSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKE 1400

Query: 669  KEALMEEILKLKSLL-STKREQITTLRT--VLKANK-QTAEVALANLK----------SK 714
            K+ +++++LK K LL   K +Q+ +       K N+ +    A+ NLK           K
Sbjct: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGK 1460

Query: 715  YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
             + E   + ET      E +AL+E    FS +       C     +    ++ L   E  
Sbjct: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520

Query: 775  KK-TLNSLLR--MAIQQKLALTQR 795
            K   LN LL    ++Q+K  + Q+
Sbjct: 1521 KTGELNQLLNAVKSMQEKTVVFQQ 1544



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 107/505 (21%), Positives = 209/505 (41%), Gaps = 58/505 (11%)

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            QFEEL  + + ++ ++++++E   Q  T  + +       E + +QE   + Q  V    
Sbjct: 1203 QFEELLQERDKLKQQVKKMEEWKQQVMTTVQNM-----QHESAQLQEELHQLQAQVLVDS 1257

Query: 120  ELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNV-------EIQRGRLRDDIKEYK 171
            +  ++L+     L  +  +NE +L +  QEL ++  ++       ++  G+L  DI   +
Sbjct: 1258 DNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKL--DIISPQ 1315

Query: 172  FREARLLQDYSE----------LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY 221
               A LL   S           L E +  LQ+++  LR++  E +     I+ L+E    
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDAT---IRTLQENNHR 1372

Query: 222  LNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSI-NDSFYTSHLHVSL 280
            L+  +     L+     Q +  ++ LK +++    L KE    +   +D   +S+ +   
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN--- 1429

Query: 281  DGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL 340
                F++   E     +A+ N  E   + ++ +       +K              L E 
Sbjct: 1430 ----FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQET 1485

Query: 341  NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE--------QQEKVTRLTE 392
            N+     L+++  +    K   LA  Q  +++ +   G L++        Q++ V    E
Sbjct: 1486 NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQE 1545

Query: 393  NLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ 452
                +  L+  +   TAL NE  R    D ++     +  E+   + H+  +E    RE 
Sbjct: 1546 RDQVMLALKQKQMENTALQNEVQR--LRDKEFR----SNQELERLRNHLLESEDSYTREA 1599

Query: 453  LKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV 512
            L A     E REA+  ++    E   + L    + +E AS Q    +  L+++L  VS  
Sbjct: 1600 LAA-----EDREAKLRKKVTVLE---EKLVSSSNAMENASHQASVQVESLQEQLNVVSKQ 1651

Query: 513  AGETQGSLSVAQDELVTFSEELANL 537
              ET   LSV+Q+++  ++  LANL
Sbjct: 1652 RDETALQLSVSQEQVKQYALSLANL 1676



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 135/770 (17%), Positives = 301/770 (39%), Gaps = 98/770 (12%)

Query: 9    EYARLVMEAQPEWLRAEVKRLSHELAETTRE--KIQAAEYGLA-VLEEKHQLKLQFEELE 65
            E  R ++  + E L  E +++  E      E  K+Q +    +  + EK ++  Q   +E
Sbjct: 326  ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385

Query: 66   VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTEL 125
              +   ++  +   E    +  N     A+   + +  I+    ++    ++  ELQ  L
Sbjct: 386  EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSL 445

Query: 126  KQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELE 185
             +L N     +S   R  S+  EL ++  N+E +   L   I E    +  L+ +  EL+
Sbjct: 446  LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE----KETLIAEIEELD 501

Query: 186  EENISLQKQVSVLR------QNQVE--FEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE 237
             +N    K + +++      QN+ +     LK ++   ++    L     D  +  ++ +
Sbjct: 502  RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561

Query: 238  RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAE 297
             +L ++   L      K  L  ++ + +   +    S++ +  + L+  +   +   +  
Sbjct: 562  EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621

Query: 298  ALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQL----- 352
             + N           L+  +++  K+ L     + V +L  + N+SE+++L + L     
Sbjct: 622  RIRNELMQS------LNQDSNSNFKDTLLKEREAEVRNL--KQNLSELEQLNENLKKVAF 673

Query: 353  -MQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-----RLQASKER 406
             ++ME EK  L+   +D + QLE      ++   +   + E L   +      L  +K+R
Sbjct: 674  DVKMENEK--LVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR 731

Query: 407  QTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE-QLKALRSTHEAREA 465
                 N+ ++   E  +   ++ +  ++     H  + +  + ++ ++  L+   E  + 
Sbjct: 732  LLEEANKYEKTIEELSNARNLNTSALQL----EHEHLIKLNQKKDMEIAELKKNIEQMDT 787

Query: 466  QHAEEKGRYEA---EGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSV 522
             H E K    +   E + LT+ ++  E    + +E  ++L++EL K S    + +    +
Sbjct: 788  DHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE----I 843

Query: 523  AQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRS 582
             +  +      L ++       NN       L+  RE Q                  R +
Sbjct: 844  LRQTIEEKDRSLGSMKEE----NNHLQEE--LERLREEQ-----------------SRTA 880

Query: 583  PILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQ----I 638
            P+  PK L             DS     S +    +        I +   II DQ    +
Sbjct: 881  PVADPKTL-------------DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927

Query: 639  KHLQAAVDRTTELSRQRIASQELGPA-----VDKDKE--ALMEEILKLKSLLSTKREQIT 691
            + LQ+  ++  E+   R   +++        ++KD+E  +L + I ++K+ L  +R+ I 
Sbjct: 928  QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987

Query: 692  TLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRN---ELKALKE 738
            T  + +    +   + + N   K++  KA     +  ++    E+K L E
Sbjct: 988  TDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE 1037



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 46/228 (20%), Positives = 114/228 (50%), Gaps = 21/228 (9%)

Query: 52   EEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHT------NHKKVAADGESREESLIQ 105
            +E+ Q+ L  ++ +++  A+++E+++L++   +++       NH   + D  +RE    +
Sbjct: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603

Query: 106  ESASKEQYYVRKVLELQTELKQLRNVLTNTQSE-NERLASVAQELKEINQNVE---IQRG 161
            +  +K +   +KV  L+ +L    N + N   + + ++ S+ ++L  +++  +   +Q  
Sbjct: 1604 DREAKLR---KKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLS 1660

Query: 162  RLRDDIKEYKFREARLLQDYSELEEE-----NISLQKQVSVLRQNQVEFEGLKHEIKRLE 216
              ++ +K+Y    A L       ++E     +  L+KQ  ++ + +   E L+ ++  L+
Sbjct: 1661 VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720

Query: 217  EETEYLNSQLEDAIRLKE---ISERQLEEALETLKTEREQKNSLRKEL 261
            E  +  N+ L+ A RL E   + E Q+EE     +  +E  + ++K+L
Sbjct: 1721 ECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 79/428 (18%), Positives = 178/428 (41%), Gaps = 51/428 (11%)

Query: 11   ARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
            A L+     E LRA    +  E +E  +++++             +L+   +E +     
Sbjct: 1319 ASLLTPQSAECLRASKSEVLSESSELLQQELE-------------ELRKSLQEKDATIRT 1365

Query: 71   IRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRN 130
            ++    +L ++        +K     +S  + L ++    ++    K L ++ +  QL +
Sbjct: 1366 LQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLS 1425

Query: 131  V---LTNTQSENERLASVAQELKEINQNVEIQRGRLRDD----IKEYKFREARLLQDYSE 183
                 TN  +ENE L      LKE    +E+  G+L+ +    ++ Y+ +E     +Y  
Sbjct: 1426 SNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKET----EYQA 1481

Query: 184  LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE--------ETEYLNSQLEDAIRLKE- 234
            L+E N+       +LR+ + E   +K +    E+        +T  LN  L     ++E 
Sbjct: 1482 LQETNMKFSM---MLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538

Query: 235  --ISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEP 292
              + +++ ++ +  LK ++ +  +L+ E+     + D  + S+    L+ L+     +E 
Sbjct: 1539 TVVFQQERDQVMLALKQKQMENTALQNEVQR---LRDKEFRSNQE--LERLRNHLLESED 1593

Query: 293  NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQL 352
            +   EAL        L       K  T  +E L   S ++ +   S     +++ L++QL
Sbjct: 1594 SYTREALAAEDREAKL------RKKVTVLEEKLVSSSNAMEN--ASHQASVQVESLQEQL 1645

Query: 353  MQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
              + +++      L  +Q+Q++    SL+  Q  +    +   A+   +  K++Q   + 
Sbjct: 1646 NVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW 1705

Query: 413  EKDRDSHE 420
            +K+ ++ E
Sbjct: 1706 KKNAENLE 1713



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 151/794 (19%), Positives = 305/794 (38%), Gaps = 96/794 (12%)

Query: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
           F + ++D+  I S  +++     +      +V       + S  Q + + +Q  + K+  
Sbjct: 157 FHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQN 216

Query: 121 LQTELKQLRNV-LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR----EA 175
           +  ELKQ R+  + + Q E   L +  Q+     +  EI R R R+++ +Y+ R    E 
Sbjct: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQ-----KLTEISR-RHREELSDYEERIEELEN 270

Query: 176 RLLQDYSELEEENIS----LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
            L Q  S + E ++S    +QK + VL+  +VE      ++++LE++ + +N +L  A  
Sbjct: 271 LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVEST---KKMEQLEDKIKDINKKLSSAEN 327

Query: 232 LKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
            ++I  R+ E+     +   E+  +L+ E S               +    +K SD   E
Sbjct: 328 DRDILRREQEQLNVEKRQIMEECENLKLECS--------------KLQPSAVKQSDTMTE 373

Query: 292 PNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQ 351
                    +  E   L +   D +    +   L   +     +L  ++ I  ++K K  
Sbjct: 374 KERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL 433

Query: 352 LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSA----LRRLQASKERQ 407
           L Q + E    L  L +  + ++ T         ++  L  NL A    L +  + KE  
Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493

Query: 408 TALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQH 467
            A   E DR + E               A K+ + + +  +L +Q     S     +   
Sbjct: 494 IAEIEELDRQNQE---------------ATKHMILIKD--QLSKQQNEGDSIISKLKQDL 536

Query: 468 AEEKGR---YEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
            +EK R    E +   +T+++ + ++   Q    L  L    +K+ D        L+ +Q
Sbjct: 537 NDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQ 596

Query: 525 DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
           +  V+  +E   L  H+   N E  +R+      E      + S         + R + +
Sbjct: 597 ESNVSIQKENLELKEHIRQ-NEEELSRIR----NELMQSLNQDSNSNFKDTLLKEREAEV 651

Query: 585 LLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHL--- 641
              K  L+                   +L     D + E   +      +R Q++     
Sbjct: 652 RNLKQNLS------------ELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699

Query: 642 --QAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKA 699
             Q ++++ T +   ++   E+   +   K+ L+EE  K +  +    E+++  R +  +
Sbjct: 700 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI----EELSNARNLNTS 755

Query: 700 NKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR-----AMFATRC 754
             Q     L  L  K + E A + + + ++  + K  K+     SSL           + 
Sbjct: 756 ALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKD--VLSSSLEEQKQLTQLINKK 813

Query: 755 DEYITQLDEMQRQLAAAEDEKKTL---NSLLRMAIQQK----LALTQRLELLELDHEQTR 807
           + +I +L E   +L    D+       N +LR  I++K     ++ +    L+ + E+ R
Sbjct: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873

Query: 808 RGRAKAAPKTKPAT 821
             +++ AP   P T
Sbjct: 874 EEQSRTAPVADPKT 887



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 52/261 (19%), Positives = 120/261 (45%), Gaps = 14/261 (5%)

Query: 7   EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-LKLQFEELE 65
           EEE +R+  E      +         L +    +++  +  L+ LE+ ++ LK    +++
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676

Query: 66  VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ---YYVRKVLELQ 122
           ++ E +    E ++    +    + +++ +  +  E+L  E    E    +  +++LE  
Sbjct: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736

Query: 123 TELKQLRNVLTNTQSENERLASVAQE-LKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
            + ++    L+N ++ N     +  E L ++NQ  +++   L+ +I++            
Sbjct: 737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVL 796

Query: 182 SELEEENISLQKQVS-VLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
           S   EE    QKQ++ ++ + ++  E LK    +L+EE +    +   A+R  EI  + +
Sbjct: 797 SSSLEE----QKQLTQLINKKEIFIEKLKERSSKLQEELD----KYSQALRKNEILRQTI 848

Query: 241 EEALETLKTEREQKNSLRKEL 261
           EE   +L + +E+ N L++EL
Sbjct: 849 EEKDRSLGSMKEENNHLQEEL 869



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 137/770 (17%), Positives = 288/770 (37%), Gaps = 149/770 (19%)

Query: 83  GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
           GQ     K +  +G    E+ + +S +KE   +  +L                +SENERL
Sbjct: 28  GQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAIL----------------RSENERL 71

Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV------- 195
             +  +L+E ++  EIQ   ++     Y+ +  +   + S L+   I+LQ Q+       
Sbjct: 72  KKLCTDLEEKHEASEIQ---IKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAA 128

Query: 196 --------------------------SVLRQNQVEFEGL---KHEIKRLEEETEYLNSQL 226
                                     S    + ++F  +   + EI RL  E   L S++
Sbjct: 129 QSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEV 188

Query: 227 EDAIRLKEISERQ------------LEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
                + + S+ Q            L+  ++ LK  R Q+     +  H MS+  + +  
Sbjct: 189 GHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEID---DHQHEMSVLQNAHQQ 245

Query: 275 HLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVS 334
            L  +    +  ++ ++     E L N  + GG                G+     S + 
Sbjct: 246 KL--TEISRRHREELSDYEERIEELENLLQQGG---------------SGVIETDLSKIY 288

Query: 335 DLLSELNISEIQKLK-----QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTR 389
           ++   + + +I+K++     +QL    ++    L++ ++ +  L   +  L+ ++ ++  
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348

Query: 390 LTENLS-ALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGE 448
             ENL     +LQ S  +Q+    EK+R   +     EV          +   A+++A  
Sbjct: 349 ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV---------FRLQQALSDAEN 399

Query: 449 LREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKK 508
              +L +L   +       AE+  + +   + L ++ SLL +   + +  L +L  E + 
Sbjct: 400 EIMRLSSLNQDNSL-----AEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454

Query: 509 VSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTS 568
           +   A              ++   EL     H    N E   + +     E +       
Sbjct: 455 IKSTATRD-----------ISLDSEL-----HDLRLNLEAKEQELNQSISEKETLIAEIE 498

Query: 569 PGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRR------ 622
              R + EA      ++L K  L+ +    D        S  S L   L+D ++      
Sbjct: 499 ELDRQNQEA---TKHMILIKDQLSKQQNEGD--------SIISKLKQDLNDEKKRVHQLE 547

Query: 623 -EPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS--QELGPAVDKDKE---ALMEEI 676
            + M+I   + + ++++   + A++    L++Q++    + L   ++K +E   ++ +E 
Sbjct: 548 DDKMDITKELDVQKEKLIQSEVALN-DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN 606

Query: 677 LKLKSLLSTKREQITTLRTVL--KANKQTAEVALANLKSKYENEKAMVTETMMKLRNELK 734
           L+LK  +    E+++ +R  L    N+ +       L  + E E   + + + +L    +
Sbjct: 607 LELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE 666

Query: 735 ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRM 784
            LK+ A             C++   QL+E          EK T+   L+M
Sbjct: 667 NLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKM 716


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 174/820 (21%), Positives = 312/820 (38%), Gaps = 116/820 (14%)

Query: 13   LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR 72
            L ME + + L  +V+ L +E+ +  +           +++EK QL+   E L  + E   
Sbjct: 494  LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553

Query: 73   SEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVL 132
              +EQ  E   Q  ++          R+ S I   A        +V +++ E K L   +
Sbjct: 554  KILEQENEHLNQTVSS---------LRQRSQISAEA--------RVKDIEKENKILHESI 596

Query: 133  TNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
              T S   +L+ +  E ++I + +E          KE   R   L  +   LE+EN  LQ
Sbjct: 597  KETSS---KLSKIEFEKRQIKKELE--------HYKEKGERAEELENELHHLEKENELLQ 645

Query: 193  KQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTERE 252
            K+++ L+    + E L+ E   LE E   L   L+        S + L   LE+L+ E  
Sbjct: 646  KKITNLKITCEKIEALEQENSELERENRKLKKTLD--------SFKNLTFQLESLEKENS 697

Query: 253  QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE-----HGG 307
            Q +    EL   +            + L+  +   +  +     E L   F+        
Sbjct: 698  QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757

Query: 308  LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLS--------ELNISEIQKLKQQLMQMEREK 359
               L ++N+      E        L S+L          + N+ E++   ++L Q+E+E 
Sbjct: 758  YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817

Query: 360  AGL---LATLQDTQKQLEHTRGSLSEQQE-KVTRLTENLSALRRLQASKERQTALDNEKD 415
              L    + L+  +KQLE     L +Q E K T L EN   +  L+  KE +T       
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE--KENKTL------ 869

Query: 416  RDSHEDGDYYEVDINGPEI------LACKYHVAVAEAGELREQLKALRSTHEAREAQHAE 469
              S E G Y E  +   E+      L  +  + +     LRE L  +    + ++  +  
Sbjct: 870  --SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDL 925

Query: 470  EKGRYEAEGQALTEKVSLLEKASRQDRELL--ARLEKELKKVSDVAGETQGSLSVAQDEL 527
            EK  +E E   L ++  L ++ S  DR  L  ++LE  LKK  ++  E   +L    +E 
Sbjct: 926  EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985

Query: 528  VTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLP 587
              ++++L            +    V  +Y    Q          R   E   + SP    
Sbjct: 986  TNYNQQL-----------RQELKTVKKNYEALKQ----------RQDEERMVQSSP---- 1020

Query: 588  KGLLAPEAGRADGGTGDSSPSPGSSL--PSPLSDPRREPMNIYNLIAIIRDQIKHLQAAV 645
                 P +G  +    +S  +    L     L +  R    +      ++ Q+K L+   
Sbjct: 1021 -----PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET-- 1073

Query: 646  DRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAE 705
             +   L  Q +A Q    ++ +    L  +  KL+   ST   Q T+L        Q A+
Sbjct: 1074 -QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM------NQNAQ 1126

Query: 706  VALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQ 765
            + +   +S  ENE   V +    L++   +L +D      L    A+  +  I++   ++
Sbjct: 1127 LLIQ--QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK 1184

Query: 766  RQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
                  E E + L       ++QK  L    ++L+++ E+
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 163/851 (19%), Positives = 328/851 (38%), Gaps = 88/851 (10%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLKLQFEEL 64
            E  E    ++E + E L   V  L      +   +++  E    +L E   +   +  ++
Sbjct: 547  ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606

Query: 65   EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV------ 118
            E +   I+ E+E  KE   +A     ++      +E  L+Q+  +  +    K+      
Sbjct: 607  EFEKRQIKKELEHYKEKGERAEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQE 664

Query: 119  -LELQTELKQLRNVLTNTQSENERLASVAQELKEINQ-NVEIQRGRLRDDIKEYKFREAR 176
              EL+ E ++L+  L + ++   +L S+ +E  ++++ N+E++R    + +K    + A+
Sbjct: 665  NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV--ESLKCASMKMAQ 722

Query: 177  LLQDYSELEEENISLQKQVSVLRQN-------QVEFEGLKHEIKRLEEETEYLNS---QL 226
            L  +  ELE E   L+K + +L+ +       +V ++GL  E +RL++  E  N    QL
Sbjct: 723  LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782

Query: 227  EDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
            E  ++  E+  + L++ LE LK   ++   L KE       N S       +  D  +  
Sbjct: 783  ESELQDLEMENQTLQKNLEELKISSKRLEQLEKE-------NKSLEQETSQLEKDKKQLE 835

Query: 287  DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE-GLAPPSPSLVSDLLSELNISEI 345
             +       AE      E   +    L+ +  T  KE G+   S          + + E+
Sbjct: 836  KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC---------VRLKEL 886

Query: 346  QKLKQQLMQMEREKAGLLATLQDT-------QKQLEHTRGSLSEQQEKVTRLTENLSALR 398
            +K  ++L++        L TL++         +Q+ +    L+ + EK+    E L  L 
Sbjct: 887  EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL--LH 944

Query: 399  RLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRS 458
              Q++ +R   L+++ +    +  +  E  I     L  +   +     +LR++LK ++ 
Sbjct: 945  DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA---LEARLEESTNYNQQLRQELKTVKK 1001

Query: 459  THEAREAQHAEEK------------GRYEAEGQALTEKV----SLLEKASRQDRELLAR- 501
             +EA + +  EE+             ++E E Q  T ++      L +  R +  L A  
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061

Query: 502  --LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANL--YHHVCMCNNETPNRVMLDYY 557
              L+ +LK++       Q  +   Q + V+  E+   L   +      N T N       
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121

Query: 558  REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
             +      + S     +      R  +      L  +  + +    +   S   SL S  
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-LLHERQASEYESLISKH 1180

Query: 618  SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEIL 677
               +    N+      + D+   L     +  +L +     QE     +K+ E +  E  
Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1240

Query: 678  KLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALK 737
            K    L  + +++    + L    +  +    NLKS   N K   T    +L  E   LK
Sbjct: 1241 K----LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT----RLEAEFSKLK 1292

Query: 738  EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE 797
            E              +C+     L +++  L   E+ +  L+ +  + +Q +  L Q +E
Sbjct: 1293 EQYQQLDITSTKLNNQCE----LLSQLKGNL--EEENRHLLDQIQTLMLQNRTLLEQNME 1346

Query: 798  LLELDHEQTRR 808
              +L H + R+
Sbjct: 1347 SKDLFHVEQRQ 1357



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 177/886 (19%), Positives = 333/886 (37%), Gaps = 187/886 (21%)

Query: 25   EVKRLSHELAETTR---EKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
            E K +  +  E TR   +K+   E      +E  QLK +  ++E++ +  R ++E+L E 
Sbjct: 358  ETKTMLEDQLEGTRARSDKLHELE------KENLQLKAKLHDMEMERDMDRKKIEELME- 410

Query: 82   FGQAHTNHKKVAADGESREESL--------------IQESASK------EQYYVRKVLEL 121
                  N     A  +S +ESL              + E+  K       +    ++L+L
Sbjct: 411  -----ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465

Query: 122  QTE-------LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
            + E       +++LR  + + +    ++  + +E + +++ VEI    L ++I + K   
Sbjct: 466  EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI----LENEIVQEKQSL 521

Query: 175  ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLN---------SQ 225
                    +L +E   L+K +  LR+N       + +IK LE+E E+LN         SQ
Sbjct: 522  QNCQNLSKDLMKEKAQLEKTIETLRENS------ERQIKILEQENEHLNQTVSSLRQRSQ 575

Query: 226  LEDAIRLKEISE------RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
            +    R+K+I +        ++E    L     +K  ++KEL HY               
Sbjct: 576  ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY--------------- 620

Query: 280  LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
                       E    AE L N   H     L  +N+    K   L             +
Sbjct: 621  ----------KEKGERAEELENELHH-----LEKENELLQKKITNL-------------K 652

Query: 340  LNISEIQKLKQQLMQMEREKAGLLATLQDTQ------KQLEHTRGSLSEQQEKVTRLTEN 393
            +   +I+ L+Q+  ++ERE   L  TL   +      + LE     L E+  ++ R  E+
Sbjct: 653  ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712

Query: 394  L--SALRRLQASKERQTALDNEKD---------RDSHEDGDYYEVDINGPEILACKYHVA 442
            L  ++++  Q   E +  L++EK+         + S +  +  EV   G +I   +    
Sbjct: 713  LKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771

Query: 443  VAEAG----ELREQLKALRSTHEAREAQHAEEK------GRYEAEGQALTEKVSLLEKAS 492
            +  +     +L  +L+ L   ++  +    E K       + E E ++L ++ S LEK  
Sbjct: 772  LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 493  RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMC-------N 545
            +Q  +   RL ++ +       E    +   + E  T S+E+  +Y   C+        N
Sbjct: 832  KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-GIYKESCVRLKELEKEN 890

Query: 546  NETPNRVMLDYYREGQGGAGRTSPGGRTSPEARG--RRSPILLPKGLLAPEAGRADGGTG 603
             E   R  +D            S   +T        + +  L   GL        +  T 
Sbjct: 891  KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950

Query: 604  DSSPSPGSSLPSPLS-------------DPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
            D      S L S L              + R E    YN       Q++     V +  E
Sbjct: 951  DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN------QQLRQELKTVKKNYE 1004

Query: 651  LSRQRIASQEL---GPAV-------DKDKEALMEEILKLKS-LLSTKREQITTLRTVLKA 699
              +QR   + +    P +       +++ +    E+LK+K  L+  +R   T     L+A
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT-----LQA 1059

Query: 700  NKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYIT 759
             KQ  +  L  L+++  N +A +    + L+ +  +L+E   T  +  A          +
Sbjct: 1060 EKQALKTQLKQLETQNNNLQAQI----LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115

Query: 760  QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
            Q   +  Q A    ++ +L +     I+++  L    + L  DHE+
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 156/773 (20%), Positives = 307/773 (39%), Gaps = 101/773 (13%)

Query: 94  ADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEIN 153
           AD +++   L QE   K +    ++L+ + EL+Q+   L   Q EN  L S A+  +   
Sbjct: 254 ADAKAKIRRLRQELEEKTE----QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309

Query: 154 QNVEIQR------GRLRDDIKEYK-------FREARLLQDYSELEEENISLQKQVSVLRQ 200
             ++  R       +L  ++  YK       F +AR+     EL+E+N  L +  ++L  
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARV----EELKEDNQVLLETKTMLED 365

Query: 201 NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL-ETLKTEREQKNSLRK 259
                     ++  LE+E   L ++L D    +++  +++EE + E +  E  QK S+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425

Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE-PNNDAEALVNGFEHGGLAKLPLDNKTS 318
            L             HL   L+ +  + + +E P       VN      L KL ++N++ 
Sbjct: 426 SL-------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 319 TPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQLMQMEREKAGLLATLQDTQK------ 371
           T   E L     S+  +    L +  E Q+L +++  +E E      +LQ+ Q       
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532

Query: 372 ----QLEHTRGSLSEQQEKVTR--------LTENLSALR-RLQASKERQTALDNEKDRDS 418
               QLE T  +L E  E+  +        L + +S+LR R Q S E +     ++++  
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592

Query: 419 HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
           HE        ++  E           E  +++++L+  +   E R  +   E    E E 
Sbjct: 593 HESIKETSSKLSKIEF----------EKRQIKKELEHYKEKGE-RAEELENELHHLEKEN 641

Query: 479 QALTEKVSLLE------KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE 532
           + L +K++ L+      +A  Q+   L R  ++LKK  D        L   + E     E
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 533 ELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
           E   L  +V    C +    ++ L+  +E +    +   G      +  +   + +    
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
           L  E  R    T ++S      L S L D   E          ++  ++ L+ +  R  +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQT-------LQKNLEELKISSKRLEQ 812

Query: 651 LSRQRIASQELGPAVDKDKEALMEEILKLKSLL----STKREQITTLRTVLKANKQTA-- 704
           L ++  + ++    ++KDK+ L +E  +L+       +T  E    +  + K NK  +  
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872

Query: 705 ----EVALANLKSKYENEKAMV------TETMMKLRNELKALKEDAATFSSLRAMFATRC 754
               + +   LK   +  K +V       +T++ LR +L + K      ++         
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932

Query: 755 DEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL-TQRLELLELDHEQT 806
           ++     + +     + +D  K L S L   +++ L +  +++  LE   E++
Sbjct: 933 EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 60/260 (23%), Positives = 112/260 (43%), Gaps = 36/260 (13%)

Query: 31   HELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQA----- 85
            HE  E   E+ QA+EY  +++ +   LK   + LEV++  +     QL +  GQ      
Sbjct: 1159 HEKLELLHER-QASEYE-SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216

Query: 86   ------------HTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRN 130
                        + NH+ VAA+     + L  E+      Y + + E   LQT+ K L++
Sbjct: 1217 MLKVEQEKMLLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272

Query: 131  VLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
            +L N++ E  RL +   +LKE  Q ++I   +L +  +     +  L ++   L ++  +
Sbjct: 1273 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1332

Query: 191  LQKQVSVLRQNQVEFEGLKH--------EIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
            L  Q   L +  +E + L H        ++  L  + E L  ++ D  +  + S  +   
Sbjct: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1392

Query: 243  ALETLKTER--EQKNSLRKE 260
               TLK  +  + K  + +E
Sbjct: 1393 NWITLKMRKLIKSKKDINRE 1412


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 196/911 (21%), Positives = 342/911 (37%), Gaps = 138/911 (15%)

Query: 3    APSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREK-------------IQAAEYGLA 49
            A +E+E+ A    E + + L  E+  L   +A  T+EK             +QA E  ++
Sbjct: 1011 AKAEKEKQAT---ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVS 1067

Query: 50   VLEE-KHQLKLQFEELEVDYEA---IRSEMEQLKEAF-GQAHTNHKKVA---ADGESREE 101
             L + K +L+ Q E+LE   E    +R + E+ K    G      + VA    D +  EE
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127

Query: 102  SLIQESASKEQYYVR-------------KVLELQTELKQLRNVLTNTQSENERL----AS 144
             L ++ +   Q  +R             K+ ELQ   ++L   L   ++   R+    A 
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187

Query: 145  VAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVE 204
             A+EL+E+++ +E   G      +  + REA L +   ELEE  +  +  V+ LR+ Q E
Sbjct: 1188 AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247

Query: 205  --------FEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS 256
                     + L+   ++LE+E   L  +++D     E   R    A +  +T  +Q + 
Sbjct: 1248 GAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE 1307

Query: 257  LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG------GLAK 310
             + ++           T    +  +    S + +    + E L++    G       L +
Sbjct: 1308 AKIKVEELQRQLADASTQRGRLQTE----SGELSRLLEEKECLISQLSRGKALAAQSLEE 1363

Query: 311  LPLDNKTSTPKKEGLAPPSPSLVSD--------------------LLSELNISEIQKLK- 349
            L    +  +  K  LA    +L  D                    LLS+ N    Q    
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSK 1423

Query: 350  ------QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQA 402
                  Q+  ++E  K  L   LQ+ ++ +E      S  ++   RL TE+      L+ 
Sbjct: 1424 YEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELER 1483

Query: 403  SKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHE- 461
            +     ALD ++           E      E +  +   A  E+  L  +L  LR  HE 
Sbjct: 1484 ATSAAAALDKKQRHLERA----LEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539

Query: 462  ---AREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQG 518
               A E    E K   E E   LT++VSL  K+ ++  +    LE E  ++     E +G
Sbjct: 1540 ALEALETLKRENKNLQE-EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598

Query: 519  SLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEAR 578
            +L + + + +    EL+ +   V     E  +    +  R  Q      S       E R
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAE-KDEECANLRRNHQRAV--ESLQASLDAETR 1655

Query: 579  GRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI 638
             R   + L K        + +G   D        L   L    R+         +++ Q+
Sbjct: 1656 ARNEALRLKK--------KMEGDLND--------LELQLGHATRQATEAQAATRLMQAQL 1699

Query: 639  KHLQAAVDRTTELSRQRIASQ--ELGPAVDKDKEALMEEILKLKSLLST-KREQITTLRT 695
            K  QA  D       QR+A++  E   A+++    L  E+ +L++ L   +R +    + 
Sbjct: 1700 KEEQAGRD-----EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQE 1754

Query: 696  VLKANKQ-----TAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMF 750
            +L+A ++     +    L N K K E + A ++  + +   E +  +E A    +  AM 
Sbjct: 1755 LLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM 1814

Query: 751  ATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQ----------QKLALTQRLELLE 800
            A    +       ++R     E   + L + L  A Q          QKL    R    E
Sbjct: 1815 AEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874

Query: 801  LDHEQTRRGRA 811
            LD EQ +   A
Sbjct: 1875 LDAEQKKHAEA 1885



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 181/815 (22%), Positives = 324/815 (39%), Gaps = 165/815 (20%)

Query: 2    SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
            SA +EEE  A          LRAE++ L   LA    ++ +  E  +++ +EK+ L LQ 
Sbjct: 891  SAQAEEELAA----------LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQ- 939

Query: 62   EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
                     +++E + L               AD E R   LI+             ++L
Sbjct: 940  ---------LQAEQDNL---------------ADAEERCHLLIKSK-----------VQL 964

Query: 122  QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
            + ++K+L          +ERL    ++ +E+N ++  +R +L D+  E K          
Sbjct: 965  EGKVKEL----------SERL----EDEEEVNADLAARRRKLEDECTELK---------- 1000

Query: 182  SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
             ++++  ++L K        + E +  ++++K L EE   L+  +    + K+  +   +
Sbjct: 1001 KDIDDLKLTLAKA-------EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053

Query: 242  EALETLKTEREQKNSLRK-ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
            +AL  L+ E ++ ++L K +L     + D      L  SL+  K                
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVED------LECSLEQEK---------------- 1091

Query: 301  NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
                     KL +D + +  K EG    +   V+D   +      Q+L+++L + + E +
Sbjct: 1092 ---------KLRMDTERAKRKLEGDLKLTQESVADAAQDK-----QQLEEKLKKKDSELS 1137

Query: 361  GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
             L   ++D Q      +  + E Q +   L E L A R  +A  E+Q A   E  R+  E
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRA---EAARELEE 1194

Query: 421  DGDYYEV--DINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
              +  E     +  +   C+   A  E G LR +L+     HEA  A       R +AEG
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREA--ELGRLRRELEEAALRHEATVAALR----RKQAEG 1248

Query: 479  QA-LTEKVSLLEKASRQDRELLARLEKELK-KVSDVAG--ETQGSLSVAQDELV-TFSEE 533
             A L E+V  L++     R+ L + + EL+ +V D+A   ET      + ++L  T+ ++
Sbjct: 1249 AAELGEQVDSLQRV----RQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ 1304

Query: 534  LANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAP 593
            L+     V     E   R + D           ++  GR   E+ G  S +L  K  L  
Sbjct: 1305 LSEAKIKV-----EELQRQLAD----------ASTQRGRLQTES-GELSRLLEEKECLIS 1348

Query: 594  EAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSR 653
            +  R       S       L   L +  +    + + +  +R     L+   +   E   
Sbjct: 1349 QLSRGKALAAQSL----EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE--- 1401

Query: 654  QRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAE--VALANL 711
               A  EL   + K    + +   K ++    + E++   +  L    Q AE  V  AN 
Sbjct: 1402 ---AQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA 1458

Query: 712  K-SKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
            K S  E  K  +      +  EL+     AA     +       +E   Q +EMQR+L A
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEA 1518

Query: 771  AEDEKKTLNS-LLRMAIQQKLALTQRLELLELDHE 804
            A+ E + L + L R+    + AL + LE L+ +++
Sbjct: 1519 AQRESRGLGTELFRLRHGHEEAL-EALETLKRENK 1552



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 115/511 (22%), Positives = 199/511 (38%), Gaps = 92/511 (18%)

Query: 349  KQQLMQMEREKAGL---LATLQDTQKQLEHTRGSLSEQQE----KVTRLTENLS-ALRRL 400
            +++L  +  E  GL   LA  +  +++LE T  S+++++     ++    +NL+ A  R 
Sbjct: 895  EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954

Query: 401  QASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH 460
                + +  L+ +    S    D  EV+ +    LA +      E  EL++ +  L+ T 
Sbjct: 955  HLLIKSKVQLEGKVKELSERLEDEEEVNAD----LAARRRKLEDECTELKKDIDDLKLTL 1010

Query: 461  EAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSL 520
               E    +EK   E + + LTE+++ L+       E +ARL KE K + +   +  G L
Sbjct: 1011 AKAE----KEKQATENKVKNLTEEMAALD-------ESVARLTKEKKALQEAHQQALGDL 1059

Query: 521  SVAQDELVTFSEELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEAR 578
               +D +   ++    L   V    C+ E   ++ +D  R  +   G       +  +A 
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA 1119

Query: 579  GRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI 638
                     K  L  +  + D        S  S L   + D +        L A ++ +I
Sbjct: 1120 Q-------DKQQLEEKLKKKD--------SELSQLSLRVEDEQL-------LGAQMQKKI 1157

Query: 639  KHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST------------- 685
            K LQA   R  EL  +  A +     V+K +     E+ +L   L               
Sbjct: 1158 KELQA---RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR 1214

Query: 686  KRE-QITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETM--------------MKLR 730
            KRE ++  LR  L+      E  +A L+ K     A + E +               +LR
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274

Query: 731  NELKALKEDAATFSSLRAMFATRCDEYITQL-------DEMQRQLAAAEDEKKTLNSLLR 783
             E+  L  +  T +  +A     C  Y  QL       +E+QRQLA A  ++  L +   
Sbjct: 1275 MEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT--- 1331

Query: 784  MAIQQKLALTQRLELLELDHEQTRRGRAKAA 814
                +   L++ LE  E    Q  RG+A AA
Sbjct: 1332 ----ESGELSRLLEEKECLISQLSRGKALAA 1358



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 47/251 (18%), Positives = 110/251 (43%), Gaps = 15/251 (5%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
            ++ A+ E LRA +++         +E ++A E    +  +   L  Q ++LE D   +  
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSG 1788

Query: 74   EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK------EQYYVRKVLELQTELKQ 127
            E+E+  +   +A    KK   D     E L +E  +       ++   + V ELQ  L++
Sbjct: 1789 EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848

Query: 128  LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
                    +   +++  +  +++E+   ++ ++ +  + +K  +  E R+ +   + EE+
Sbjct: 1849 AEQAA--LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 1906

Query: 188  NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
              +L +   ++ + Q + +  K   ++ EE  +  N+ L    +    ++ +L++A E  
Sbjct: 1907 RKNLARMQDLVDKLQSKVKSYK---RQFEEAEQQANTNLAKYRK----AQHELDDAEERA 1959

Query: 248  KTEREQKNSLR 258
                 Q N LR
Sbjct: 1960 DMAETQANKLR 1970


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 178/880 (20%), Positives = 343/880 (38%), Gaps = 111/880 (12%)

Query: 16   EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
            E +   ++ + +R   ELA +   + +  E  +++L+EK+ L+LQ          ++SE 
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ----------VQSET 899

Query: 76   EQLKEAFGQAHTNHK---------KVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
            E L +A  +     K         K   +    EE +  E  +K++    K   L+ ++ 
Sbjct: 900  ENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID 959

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
             L   LT  + E     +  + L E    +E    +L  + K  +    + L D    E+
Sbjct: 960  DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019

Query: 187  ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQ 239
            +   L K  + L Q   + EG   + K+L  + E    +LE  +++ + S       ++Q
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079

Query: 240  LEEALE---------TLKTEREQKNSLR-----KEL-------------SHYMSINDSFY 272
            +EE L+           K + EQ +SL+     KEL              H +       
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139

Query: 273  TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
             S L   L+ +    + A     A+  +N        K+  D + +T + E  A      
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199

Query: 333  VSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
             +D ++EL   I  +Q++KQ+L   E+EK+ L   + D    +E    +LS+ +  + R 
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKL---EKEKSELKMEIDDMASNIE----ALSKSKSNIERT 1252

Query: 391  TENL-SALRRLQASKERQTA----LDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
               +      ++A  E+QT     L+ +K R   ++G+          +++       A 
Sbjct: 1253 CRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL 1312

Query: 446  AGELREQLKALRSTHEAREAQ-HAEEKGR---------YEAEGQALTEKVSLLEKASRQD 495
              +L E  + +    +A+ A  HA +  R         YE E +A  E    L KA+ + 
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372

Query: 496  RELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV--- 552
             +   + E +  + ++   E +  L+    E    +EE     +  C    +T  R+   
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQE----AEENTETANSKCASLEKTKQRLQGE 1428

Query: 553  MLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL------LPKGLLAPEAGRADGGTGDSS 606
            + D  R+ +    R+     T  + +     +L      L +     EA + +  +  + 
Sbjct: 1429 VEDLMRDLE----RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484

Query: 607  ----PSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI----KHLQAAVDRTTELSRQ---- 654
                 +    +   L   RRE  N+   I+ + +QI    K+LQ A ++T +L  Q    
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA-EKTKKLVEQEKSD 1543

Query: 655  -RIASQELGPAVDKDKEALME---EILKLKSLLSTKREQITTLRTVLKANKQTAEVALAN 710
             ++A +E+  +++ ++  ++    E+ ++KS L  K  +       LK N Q A  AL +
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603

Query: 711  LKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
            +       +        K+  +L  ++      +   A           QL + Q  L  
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663

Query: 771  AEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
            A    + L   L +  ++   L + LE +++  EQT R R
Sbjct: 1664 ALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 185/917 (20%), Positives = 363/917 (39%), Gaps = 156/917 (17%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE-- 63
            E+E++A    E + + L  E+  L   +++ T+EK    E     L++     LQ EE  
Sbjct: 969  EKEKHAT---ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD-----LQVEEDK 1020

Query: 64   ----------LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL---------I 104
                      LE   + +   +EQ K+         +K+  D +  +ES+         I
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080

Query: 105  QESASKEQY------------------YVRKVLELQTELKQLRNVLTNTQSENERL---- 142
            +E   K+++                  + +K+ ELQ  +++L   +    +   ++    
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR 1140

Query: 143  ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
            + +A+EL+EI++ +E   G     I+  K REA   +   +LEE  +  +   + LR+ Q
Sbjct: 1141 SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQ 1200

Query: 203  VE--------FEGLKHEIKRLEEETEYLNSQLED-AIRLKEISE---------RQLEEAL 244
             +         + L+   ++LE+E   L  +++D A  ++ +S+         R +E+  
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260

Query: 245  ETLKTEREQKNSL--------------RKELSHYMSINDSFYTS------HLHVSLDGLK 284
              +K + EQ+  L                ELSH +   +S  +        L   L+ LK
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320

Query: 285  --FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK-EGLAPPSPSLVSDLLSELN 341
                ++    N  A AL +      L +   + +     + +     + S V+   ++  
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380

Query: 342  ISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR-L 400
               IQ+ ++    +E  K  L   LQ+ ++  E      +  ++   RL   +  L R L
Sbjct: 1381 TDAIQRTEE----LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436

Query: 401  QASKERQTALDNEKDRDSHEDGDYYE-VDINGPEILACKYHVAVAEAGELREQLKALRST 459
            + S      LD ++        ++ + +D +  E+ A     A  E+  L  +L  +R+ 
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA-----AQKESRSLSTELFKMRNA 1491

Query: 460  HEA----REAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGE 515
            +E      E    E K   E E   LTE+++   K  ++  +    +E+E   +     E
Sbjct: 1492 YEEVVDQLETLRRENKNLQE-EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550

Query: 516  TQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSP 575
             +GSL   + +++    EL+ +   +     E    +     R  Q  A           
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIE-QLKRNSQRAAEALQ--SVLDA 1607

Query: 576  EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIR 635
            E R R   + L K        + +G   +     G S         R+       +  ++
Sbjct: 1608 EIRSRNDALRLKK--------KMEGDLNEMEIQLGHS--------NRQMAETQKHLRTVQ 1651

Query: 636  DQIKHLQAAVD---RTTELSRQRIASQELGPAVDKDKEALMEEILKLK-SLLSTKREQIT 691
             Q+K  Q  +D   R+ E  ++++A       V++    L+EE+ ++K +L  T+R +  
Sbjct: 1652 GQLKDSQLHLDDALRSNEDLKEQLA------IVERRNGLLLEELEEMKVALEQTERTRRL 1705

Query: 692  TLRTVLKANKQ-----TAEVALANLKSKYENE----KAMVTETMMKLRN-ELKALKEDAA 741
            + + +L A+ +     +   +L N K K E +    +A V  ++ + RN E KA K  A 
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKK--AI 1763

Query: 742  TFSSLRAMFATRCDEYITQLDEMQRQL-AAAEDEKKTLNSLLRMAIQQKLALTQRLELL- 799
            T +++ A    +  +    L+ M++ L    +D +  L+   ++A++      Q+LE   
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRV 1823

Query: 800  -----ELDHEQTRRGRA 811
                 ELD EQ R   A
Sbjct: 1824 RELENELDVEQKRGAEA 1840



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 147/749 (19%), Positives = 296/749 (39%), Gaps = 94/749 (12%)

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
            +++ +L + ++E E +A++ ++ +   +  E+ R   R   KE + +   LLQ+ ++L+ 
Sbjct: 839  KIKPLLKSAEAEKE-MATMKEDFERTKE--ELARSEARR--KELEEKMVSLLQEKNDLQ- 892

Query: 187  ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE---ISERQLEEA 243
              + +Q +   L   +   EGL      LE + + L  +LE+   +       +R LE+ 
Sbjct: 893  --LQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950

Query: 244  LETLK-------------------TEREQKN------SLRKELSHYMSINDSFYTSHLHV 278
              +LK                   TE + KN      +L + +S       S   +H   
Sbjct: 951  CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH-QQ 1009

Query: 279  SLDGLKFSDDAA----EPNNDAEALVNGFEHGGL---AKLPLDNKTSTPKKEGLAPPSPS 331
            +LD L+  +D      + N   E   +  E G L    KL  D + +  K EG    S  
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLE-GSLEQEKKLRADLERAKRKLEGDLKMSQE 1068

Query: 332  LVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
             + DL ++      Q+++++L + E E + L A + D Q      +  + E Q ++  L 
Sbjct: 1069 SIMDLENDK-----QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123

Query: 392  ENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE 451
            E + A   L+A  E+Q    ++  R+  E  +  E                 AE  ++R 
Sbjct: 1124 EEIEAEHTLRAKIEKQR---SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR 1180

Query: 452  QLKALRSTHEAREAQHAEEKGRYEAE-GQALTEKVSLLEKASRQDRELLARLE---KELK 507
             L+     HEA  A   +++    AE G+ +     + +K  ++  EL   ++     ++
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240

Query: 508  KVSDVAGETQGSLSVAQD---ELVTFSEELANLYHHVCM--CNNETPNRVMLDYYREGQG 562
             +S      + +    +D   E+    E+   L H + M     +T N  +     E + 
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300

Query: 563  GAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRR 622
               + +     S +A  ++   L  +     +A  A      SS      L     + + 
Sbjct: 1301 LISQLT----KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356

Query: 623  EPMNIYNLIAIIRDQI-----KHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEIL 677
                +   ++    ++     K+   A+ RT EL     A ++L   + + +E       
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE---AKKKLAQRLQEAEENTETANS 1413

Query: 678  KLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKL---RNELK 734
            K  SL  TK+     +  +++ + + +  A A L  K  N   ++ E   KL   + EL+
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMR-DLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELE 1472

Query: 735  ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLL------------ 782
            A ++++ + S+         +E + QL+ ++R+    ++E   L   +            
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532

Query: 783  --RMAIQQKLALTQRLELLE--LDHEQTR 807
              ++  Q+K  L   LE +E  L+HE+++
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESK 1561



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 139/701 (19%), Positives = 263/701 (37%), Gaps = 138/701 (19%)

Query: 157  EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRL 215
            E +   +++D +  K   AR      ELEE+ +SL ++ + L+ Q Q E E L    +R 
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909

Query: 216  EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSH 275
            E             I+ K + E +++E  E L+ E E  + L   ++   ++ D    S 
Sbjct: 910  E-----------GLIKSKILLEAKVKELTERLEEEEEMNSEL---VAKKRNLEDK--CSS 953

Query: 276  LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSD 335
            L   +D L+ +                     L K+  +   +  K + L+    +L   
Sbjct: 954  LKRDIDDLELT---------------------LTKVEKEKHATENKVKNLSEEMTAL--- 989

Query: 336  LLSELNISEIQKLKQQL----------MQMEREKA-GLLATLQDTQKQLEHTRGSLSEQQ 384
               E NIS++ K K+ L          +Q+E +K  GL+      ++Q +   GSL  +Q
Sbjct: 990  ---EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL--EQ 1044

Query: 385  EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
            EK  R     + L R +   E    +  E   D   D    E  +   E    +    + 
Sbjct: 1045 EKKLR-----ADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099

Query: 445  EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
            +     EQ+ +L+   + +E Q   E+   E E +      +L  K  +Q  +L   LE+
Sbjct: 1100 D-----EQVHSLQFQKKIKELQARIEELEEEIEAEH-----TLRAKIEKQRSDLARELEE 1149

Query: 505  ELKKVSDVAGETQGSLSVAQDELVTFSE-----ELANLYHHVCMCNNETPNRVMLDYYRE 559
              +++ + +G T   + + +     F +     E A L H                  R+
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT-----------LRK 1198

Query: 560  GQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSD 619
             Q  A   +  G      +  +  +   K  L  E                  + S +  
Sbjct: 1199 KQ--ADSVAELGEQIDNLQRVKQKLEKEKSELKMEI---------------DDMASNIEA 1241

Query: 620  PRREPMNIYNLIAIIRDQIKHLQAAVDRTTEL--------SRQRIASQELGPAVD----- 666
              +   NI      + DQ   ++A  ++ T+L        +R +  + EL   V+     
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301

Query: 667  -----KDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM 721
                 K K+AL +++ +LK  +  + +    +   L++++   ++    L+ +YE E+  
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL----LREQYEEEQEA 1357

Query: 722  VTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLA----AAEDEKKT 777
              E         +AL +  +  +  R  + T   +   +L+E +++LA     AE+  +T
Sbjct: 1358 KAELQ-------RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410

Query: 778  LNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
             NS      + K  L   +E L  D E++    A    K +
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQR 1451



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 53/261 (20%), Positives = 111/261 (42%), Gaps = 28/261 (10%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTR-------EKIQAAEYGLAVLEEKHQLKLQFEELEV 66
            ++E +   L  E++ +   L +T R       E + A++    +  +   L    ++LE 
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736

Query: 67   DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
            D    ++E+E   +    A    KK   D      +++ E   KEQ     +  ++  L+
Sbjct: 1737 DIAQCQAEVENSIQESRNAEEKAKKAITDA-----AMMAEELKKEQDTSAHLERMKKNLE 1791

Query: 127  QLRNVLTNTQSENERLA---------SVAQELKEINQNVEIQRGRLRDDIKEYKFREARL 177
            Q    L +   E E+LA          +   ++E+   +++++ R  + +K     E ++
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851

Query: 178  LQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE 237
             +   + EE++ ++ +   ++ + Q + +  K   ++ EE  E  N+QL    R+    +
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK---RQAEEAEEQANTQLSRCRRV----Q 1904

Query: 238  RQLEEALETLKTEREQKNSLR 258
             +LEEA E       Q N LR
Sbjct: 1905 HELEEAAERADIAESQVNKLR 1925


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 164/814 (20%), Positives = 329/814 (40%), Gaps = 115/814 (14%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETT---REKIQAAEYGLAVL-------EEKHQLKLQFEE 63
            +M+ + +  + E+  LS +L +     +  I  +E   A+        EEK +L  Q ++
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416

Query: 64   LEVDYEAIRSE----MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            L    + +  E    +EQ+ + +    +  KK A    ++ ++ ++E            L
Sbjct: 1417 LSFKVDTLSKEKISALEQVDD-WSNKFSEWKKKAQSRFTQHQNTVKE------------L 1463

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            ++Q ELK           ++E++  + +EL + N+  +  +G + DD  + + +E+ L  
Sbjct: 1464 QIQLELKS-----KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL-- 1516

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR----LKEI 235
              +EL+ +   + +    + Q  +E E L   +K   ++ +  + +L   ++    L E 
Sbjct: 1517 -ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE 1575

Query: 236  SERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNND 295
             + +++EA E + T   Q  S++ EL             H+++S+   +    A E   +
Sbjct: 1576 KDNRVKEAEEKILTLENQVYSMKAELE-----TKKKELEHVNLSVKSKEEELKALEDRLE 1630

Query: 296  AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL------VSDLLSELNIS------ 343
            +E+     E     K   + K +  KK+ L+                LSELN        
Sbjct: 1631 SESAAKLAE----LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686

Query: 344  EIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQA 402
            E+  L+++L  +E  ++  L   +  +    +T    ++ Q  V +   E +S L+R   
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746

Query: 403  SKER---QTALDNEKDRDSH-EDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRS 458
             KE+   +   + E+   SH E    Y+  +   E    K H   +  G L+E+L+    
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806

Query: 459  THEAREAQHAE-EKGRYEAEGQALTEKVSLLEKASRQDRELLAR-LEKELKKVSDVAGET 516
             +    AQH E E G+   + +   E V    + + Q++EL  + LE+++K++       
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866

Query: 517  QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
            +    V  +EL +  E+L  L     M     P  ++ +   E                 
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQ---MDGRNKPTELLEENTEEKS--------------- 1908

Query: 577  ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
                +S ++ PK L   EA   D             L   L+   RE   +   I  ++ 
Sbjct: 1909 ----KSHLVQPKLLSNMEAQHND-------------LEFKLAGAEREKQKLGKEIVRLQK 1951

Query: 637  QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTV 696
             ++ L+    +  E+ ++    +       ++K    +E L+LK   ST ++ +    T 
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQER------EEKIKQEQEDLELKH-NSTLKQLMREFNTQ 2004

Query: 697  LKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDE 756
            L   +Q  E+ +    +K +  +A + E+  +  N+L  LK+ A     L+   A R +E
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL--LKKIAEKDDDLKRT-AKRYEE 2061

Query: 757  YITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
                LD  + ++ A   + +T    L+   QQKL
Sbjct: 2062 I---LDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 124/550 (22%), Positives = 241/550 (43%), Gaps = 50/550 (9%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
            +    +E E+  L ++++ E L+A   RL  E A    E  + AE  +A +  K QL  Q
Sbjct: 1601 LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAI--KKQLLSQ 1658

Query: 61   FEELEVDY----EAIRSEME-QLKEAFGQAHTNHKKVAADGESREESLIQESASK----- 110
             EE E  Y    E+  SE+  +L+E   + H   +K+ +   S+ E+LI   ++K     
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718

Query: 111  -EQYYVRKVLELQTELKQLRNVLTNTQSENERLAS-VAQELKEINQNVEIQRGRLRDDIK 168
             EQ        +Q   ++  +VL    +E E+L   V QE +E   +    R + ++ + 
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1778

Query: 169  EYKFREARLLQDYS---ELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQ 225
            + +  EA+  +D S    L+EE     K+ S++    VE EG K+ I+  ++  E +   
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA-KQNLENVFDD 1837

Query: 226  LEDAIRLKEISERQLEEALETLKTER-EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLK 284
            ++  ++ KE++ + LE+ ++ L +    QK   R E+    S  +          +DG  
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ---QMDGRN 1894

Query: 285  FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT-------STPKKEGLAPPSPSLVSDL- 336
               +  E N + ++  +  +   L+ +   +         +  +K+ L      L  DL 
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954

Query: 337  -LSELNISEIQKLKQQLMQ-----MEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
             L + +  E++ LK++  Q     +++E+  L      T KQL     +   Q+E+   +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014

Query: 391  T--ENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEA 446
            T  E ++  + ++A   +  Q   +    + + +D D         EIL  +     A+ 
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV 2074

Query: 447  GELREQLKALRSTHEAREAQHAEEKGR-----YEAEGQALTEKVSLLEKASRQD---REL 498
             +L+ QL+ L+  ++ ++ +  E  G       E + Q L +K +L+  +  ++   RE 
Sbjct: 2075 RDLQTQLEELQKKYQ-QKLEQEENPGNDNVTIMELQTQ-LAQKTTLISDSKLKEQEFREQ 2132

Query: 499  LARLEKELKK 508
            +  LE  LKK
Sbjct: 2133 IHNLEDRLKK 2142



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 176/864 (20%), Positives = 353/864 (40%), Gaps = 136/864 (15%)

Query: 11   ARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
            A L+       L A++++L+ E   T     Q A + L   EEK     Q + ++ D E+
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEE-QNTLNISFQQATHQL---EEKEN---QIKSMKADIES 1315

Query: 71   IRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESAS--------KEQYYVRKVLELQ 122
            + +E E L++  G    N ++ A++ ES    L +E +         KE+   +KV E+ 
Sbjct: 1316 LVTEKEALQKEGG----NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV-EIS 1370

Query: 123  TELKQLRNV---LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            +  KQL ++   L N+ S +E+ A+++   K+ ++    ++  L D +++  F+   L +
Sbjct: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE----EKCELLDQVQDLSFKVDTLSK 1426

Query: 180  D-YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL---EDAIRLKEI 235
            +  S LE+ +    K     ++ Q  F   ++ +K L+ + E  + +    ++ I L + 
Sbjct: 1427 EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE 1486

Query: 236  SERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNND 295
               Q  +  + LK E E   S  ++    +       T+ +      ++  D   +   +
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI------MELEDHITQKTIE 1540

Query: 296  AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
             E+L    ++    K  +++K    K +             L E   + +++ +++++ +
Sbjct: 1541 IESLNEVLKNYNQQK-DIEHKELVQKLQHFQE---------LGEEKDNRVKEAEEKILTL 1590

Query: 356  EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENL-------------SALRRLQA 402
            E +   + A L+  +K+LEH   S+  ++E++  L + L              A +++ A
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650

Query: 403  SKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHE- 461
             K++  +   EK+    +  + +  ++N       K      E   L E+LK++ S+   
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELN------TKLQEREREVHILEEKLKSVESSQSE 1704

Query: 462  ----AREAQH-AEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGET 516
                 R A++ A    + EA+ Q   +K +  EK S   R L    EKE K +  V  E 
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQK-TYEEKISVLQRNL---TEKE-KLLQRVGQEK 1759

Query: 517  QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
            + ++S   +    + E L  L H       +  ++ M+ + +E                E
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEA---KQHEDQSMIGHLQE--------------ELE 1802

Query: 577  ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
             + ++  +++        A   +   G ++     +L +   D ++          I+  
Sbjct: 1803 EKNKKYSLIV--------AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854

Query: 637  QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEAL--MEEILKLKSLLSTKREQITTLR 694
            +IK L + + R  E+   R+  +EL    +K  +AL  M+   K   LL    E+ +   
Sbjct: 1855 KIKELDSCLVRQKEV--HRVEMEELTSKYEK-LQALQQMDGRNKPTELLEENTEEKSKSH 1911

Query: 695  TV---LKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMF 750
             V   L +N +     L    +  E EK  + + +++L+ +L+ L KE       L+  +
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971

Query: 751  ATRCDEYITQ----------------LDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQ 794
                +E I Q                + E   QLA  E E       L M I++ +   Q
Sbjct: 1972 DQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE-------LEMTIKETINKAQ 2024

Query: 795  RL--ELLELDHEQTRRGRAKAAPK 816
             +  ELLE   E+T +   K A K
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEK 2048



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 167/895 (18%), Positives = 342/895 (38%), Gaps = 145/895 (16%)

Query: 32   ELAETTREKIQAAEYGLA--------VLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFG 83
            E+ E T EK+   +  L         VL+ +H+L+ +   L+   + ++ E+E   +   
Sbjct: 670  EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE-- 727

Query: 84   QAHTNHKKVAADGESREESL-IQ--ESASKEQYYVRKVL--ELQTELKQLRNVLTNTQSE 138
                NH +   D   +E  + IQ  E A K+Q    ++L  E    LK+ +  + N +++
Sbjct: 728  --QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
             +R     Q+        +  +    +  K Y+ + A+L Q   +LE E I L KQV+ +
Sbjct: 786  IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845

Query: 199  RQNQ----VEFEGLKHEIKRLEEETEYLNSQLEDAIR-LKEISERQLE------EALETL 247
               +     E +  K +++ L ++ E  NS++E  ++ L ++ E +LE      E  + +
Sbjct: 846  EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905

Query: 248  KTERE------------------QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDA 289
              E+E                  QK S +++  H   +N+ + T   +      K    A
Sbjct: 906  LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI--LNEEYETKFKNQEKKMEKVKQKA 963

Query: 290  AEPNN-------DAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNI 342
             E          D EA +         +L    K    K   +A  + + +SD +S L  
Sbjct: 964  KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023

Query: 343  SEIQKLKQQLMQMEREKAGLLATL------QDTQKQLEHTRGSLSEQQEKVTRLTENL-- 394
            ++ +++ + L ++ R +   + ++      Q  ++  E     L E++++V  L + +  
Sbjct: 1024 NQKEQI-ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082

Query: 395  -----------------------SALRRLQASKERQTALDNEKDRDSHE---DGDYYEVD 428
                                   + L  LQ   ++++A  N   +D  +     +  EVD
Sbjct: 1083 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142

Query: 429  INGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLL 488
            +N           ++ E   L+EQL  L+   E  + + +E   + +   +      S  
Sbjct: 1143 LN----------KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192

Query: 489  EKASR--QDREL-LARLEKELKKVSDV-AGETQGSLSVAQDELVTFSEELAN-LYHHVCM 543
            EK+++  +D+ L   +L +EL    D+   +T+  L    +EL+  S    N +   +  
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252

Query: 544  CNNETPN---------------RVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL--- 585
            C + T                    L    E Q     +        E +  +   +   
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312

Query: 586  LPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNL-----------IAII 634
            +   +   EA + +GG    + S   S  + L     E +N   L           I+ +
Sbjct: 1313 IESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSL 1372

Query: 635  RDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST-KREQITTL 693
              Q+  L   +  +  LS +  A   L    D++K  L++++  L   + T  +E+I+ L
Sbjct: 1373 SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL 1432

Query: 694  RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATR 753
              V   + + +E      +S++   +  V E  ++L  + K   E     + L+     +
Sbjct: 1433 EQVDDWSNKFSEWK-KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491

Query: 754  CDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRR 808
               +     EM+   +  E ++  L + L+         +Q   ++EL+   T++
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELK---------SQTARIMELEDHITQK 1537



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 135/640 (21%), Positives = 260/640 (40%), Gaps = 95/640 (14%)

Query: 5    SEEEEYARLVMEAQPEWLRAE---VKRLS------HELAETTREKIQAAEYGLAVLEEKH 55
            S EE+ A+L    + E  R E    K+L        E  +   EK Q+ EY     E++ 
Sbjct: 473  SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS-EYLKISQEKEQ 531

Query: 56   QLKLQFEELEVDYEAIRSEME-QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYY 114
            Q  L  EELE+  +AI +E E +L++   +A T   ++     S E+SL +     +   
Sbjct: 532  QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591

Query: 115  VRKVLELQTELKQLRNVLTNTQSENERL-----ASVAQELKEINQNVEIQRGRLRDDIKE 169
            V    E     K++  ++   ++E E L     A   ++L+ + Q  + +  +LR+  ++
Sbjct: 592  VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651

Query: 170  YKFREARLLQD-----YSELEEENISLQKQVSVLRQNQVEFEGLKHEIK-------RLEE 217
             K     LL+D      + +EE N   +K +  L   Q E E L  E+        +LEE
Sbjct: 652  EK---ETLLKDKEIIFQAHIEEMN---EKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705

Query: 218  ETEYL----------------------NSQLEDAIRLKEISERQLEEALETLKTE----- 250
            E   L                        Q++  I+  E+S ++ E+AL+    +     
Sbjct: 706  ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765

Query: 251  REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
            +E+   L++  +H  ++      S   +     K   D  +    A           LA+
Sbjct: 766  KERDKHLKEHQAHVENLEADIKRSEGELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQ 823

Query: 311  LP---LDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI------QKLKQQLMQMEREKAG 361
            L    LD +T             +   D+ +EL+  +I      Q+L++Q  +ME++   
Sbjct: 824  LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883

Query: 362  LL----ATLQDTQKQLEHTRGSLSEQQEKVTRLTE----NLSALRRLQASKERQTALDNE 413
            L     + L+D  K+ E T+  L E++  + ++ E     +  L +  ++KE    + NE
Sbjct: 884  LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943

Query: 414  --KDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ-HAEE 470
              + +  +++    +V     E+        + +  +L+++L+        +E Q +A+ 
Sbjct: 944  EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003

Query: 471  KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTF 530
                +A    +++ VS LE   ++  E L  + +  ++++DV    +  L+   +EL   
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--RELNDVISIWEKKLNQQAEELQEI 1061

Query: 531  SE--------ELANLYHHVCM--CNNETPNRVMLDYYREG 560
             E        E+A L   + +  C  E  N+ +     EG
Sbjct: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 137/715 (19%), Positives = 284/715 (39%), Gaps = 115/715 (16%)

Query: 133 TNTQSENERLASVAQELKEINQNVEIQR-GRLRDDIKEYKFREARLLQDYSELEEENISL 191
           ++  SE E L   +  L   N+   IQR  R+   +  Y+ + + L+  Y  L+ E   L
Sbjct: 118 SDMDSEAEDLVGNSDSL---NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL 174

Query: 192 QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
           Q    +L Q+Q +       ++R+ E  E L    +    L+E  +  LEE  + +   +
Sbjct: 175 Q---GILSQSQDK------SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225

Query: 252 EQKNSLRKELSHY-MSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
            Q + L++ L +  M+++       L    +     ++   P +D E +V      G + 
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEEN---PESDGEPVVED----GTSV 278

Query: 311 LPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQ 370
             L+      K++           +LL       IQ  K+Q   +  EK  L   L +  
Sbjct: 279 KTLETLQQRVKRQ----------ENLLKRCK-ETIQSHKEQCTLLTSEKEALQEQLDERL 327

Query: 371 KQLEHTRG-SLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
           ++LE  +   ++E+ + +T+L +  + + +L+  K    A   E  R  HE  +  E +I
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA---ETKRQMHETLEMKEEEI 384

Query: 430 NGPEILACKYHVAVAEAGELREQLKALRST-HEAREAQHAEEKGRYEAEGQALTEKVSLL 488
                             +LR ++K + +   E RE +   E+  +E   +AL    S  
Sbjct: 385 -----------------AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL----STA 423

Query: 489 EKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNET 548
           +K     R+L A +++++K +             +++E ++  +EL+ +   V     ++
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIE----------KTSEEERISLQQELSRVKQEVVDVMKKS 473

Query: 549 PNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS 608
               +    +  +    R         + R R     +   L   E  +++         
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL---EKSQSEYLKISQEKE 530

Query: 609 PGSSLP---------SPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQ 659
              SL          + L++   +  ++       R +I  L+++++++ + ++ +  S+
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--SK 588

Query: 660 ELGPAVDKDKEALMEEILKL-----KSLLSTKREQITTLRTVLKANKQTAEVALANLKSK 714
           +L   ++ +K    +EI  +       L S K +Q       L+  KQ  +  +  L+ K
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 715 YENEKA----------------MVTETMMKL---RNELKALKEDAATFSSLRAMFATRCD 755
            E EK                 M  +T+ KL   + EL++L  + +     R        
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 756 EYITQLDEMQRQLAAAEDEKKT-----LNSLLR---MAIQQ-KLALTQRLELLEL 801
               Q D+M+++L A  DE+K      ++S+++   ++IQ+ + AL  ++  LEL
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 150/790 (18%), Positives = 308/790 (38%), Gaps = 89/790 (11%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVL-EEKHQLKLQFEELEVDYEAIRSEMEQL 78
            E L+  VKR    L +  +E IQ+ +    +L  EK  L+ Q +E          E+E++
Sbjct: 282  ETLQQRVKR-QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER-------LQELEKI 333

Query: 79   KEAFGQAHTNHKKVAADGESREESLIQESA---SKEQYYVRKVLEL-QTELKQLRNVLTN 134
            K+      T       D ++  E L Q+     ++ +  + + LE+ + E+ QLR+ +  
Sbjct: 334  KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQ 393

Query: 135  TQSENERLA--------SVAQELKEI---NQNVEIQRGRLRDDIKEYKFREARLLQDYSE 183
              ++ E L         +  +EL++     Q  E  R +L+ ++ E    + + ++  SE
Sbjct: 394  MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE----QIKTIEKTSE 449

Query: 184  LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
              EE ISLQ+++S ++Q  V+        K  EE+   L    E  +  K   E++L + 
Sbjct: 450  --EERISLQQELSRVKQEVVDVMK-----KSSEEQIAKLQKLHEKELARK---EQELTKK 499

Query: 244  LETLKTE--REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDA--AEPNNDAEAL 299
            L+T + E   + K +L K  S Y+ I+         ++L+ L+    A   E  N    L
Sbjct: 500  LQTREREFQEQMKVALEKSQSEYLKISQE-KEQQESLALEELELQKKAILTESENKLRDL 558

Query: 300  VNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK 359
                E      L L++      +E     + +   DL   L   + +  K+  + +E+ K
Sbjct: 559  QQEAETYRTRILELESSLEKSLQE-----NKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613

Query: 360  AGLLATLQDTQKQLEHTRGSL-SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDS 418
              L        + L+H + +L +E+ + + +  +      R +  +E++T L   KD++ 
Sbjct: 614  TEL--------ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL---KDKEI 662

Query: 419  HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREA-QHAEEKGRYEAE 477
                   E++    E L  K     + + EL E LKA     E     +   +K + E E
Sbjct: 663  IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722

Query: 478  GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANL 537
             +   +K    ++     +E    +++  K + D   + +  L      L      + NL
Sbjct: 723  AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782

Query: 538  YHHVCMCNNETPN-RVMLDYYREGQGGAGRTSPGGRTSPEARGRR------SPILLPKGL 590
               +     E       LD ++  Q      +           ++        ILL K +
Sbjct: 783  EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842

Query: 591  LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
               EA + D  T                +     + + +L+  +  Q   ++  V   T+
Sbjct: 843  AEVEAQKKDVCT----------------ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886

Query: 651  LSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALAN 710
            +   ++  ++     ++ K+ L+E+   +  +   ++++I  L   L A + +  +    
Sbjct: 887  VYESKL--EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944

Query: 711  LKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
             ++K++N++  + +   K +   + LK+         A      +    +L + ++Q  A
Sbjct: 945  YETKFKNQEKKMEKVKQKAKEMQETLKK---KLLDQEAKLKKELENTALELSQKEKQFNA 1001

Query: 771  AEDEKKTLNS 780
               E    NS
Sbjct: 1002 KMLEMAQANS 1011



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 123/601 (20%), Positives = 240/601 (39%), Gaps = 76/601 (12%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKR--LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE 63
            + + Y   + + Q + L  E +R  L+ ++AE   +K         V  E    K+Q ++
Sbjct: 813  QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD-------VCTELDAHKIQVQD 865

Query: 64   LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
            L    E   SEMEQ  ++  Q + +  +   DG   +E   Q    KE      +L+++ 
Sbjct: 866  LMQQLEKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILVEKE----NMILQMRE 918

Query: 124  ELKQLRNVLTNTQSENERLASVAQELKEIN-QNVEIQRGRLRDDIKE-YKFREARLLQDY 181
              K+   +LT   S  E    +  E  E   +N E +  +++   KE  +  + +LL   
Sbjct: 919  GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978

Query: 182  SEL--EEENISL-------QKQVSVLRQNQVEFEGLKHEIKRLEEE--------TEYLNS 224
            ++L  E EN +L       Q    +L   Q    G+   + RLE          TE    
Sbjct: 979  AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038

Query: 225  QLEDAIRL--KEISER--QLEEALETLKTEREQK-NSLRKELSHYMSINDSFYTSHLHVS 279
            +L D I +  K+++++  +L+E  E    E+EQ+   L++++  +    +        + 
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098

Query: 280  LDGLKFS---DDAAEPNNDAEALVNGFEH------GGLAKLPLDNKTSTPKKEGLAPPSP 330
             +G+K     ++  E      A VN            L KL +D   S   KE       
Sbjct: 1099 EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL--KENTFLQEQ 1156

Query: 331  SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVT-- 388
             +   +L+E +  ++ +L  +L   + E   L ++ + + K LE       +  E++   
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216

Query: 389  -----RLTENLSALRR---LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
                 + TE L   +    +  S  +  A+ +      H      E  +    I  C   
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL----IKTCTVS 1272

Query: 441  VAVAEAGELREQLKAL-----RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQD 495
               A+  +L E+   L     ++TH+  E ++  +  + + E   +TEK +L ++   Q 
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE-SLVTEKEALQKEGGNQQ 1331

Query: 496  RELLARLEKE--LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVM 553
            +   A  EKE  + ++     E   ++++ ++EL     E+++L   +   N +  N + 
Sbjct: 1332 Q---AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388

Query: 554  L 554
            L
Sbjct: 1389 L 1389


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 173/821 (21%), Positives = 312/821 (38%), Gaps = 117/821 (14%)

Query: 13   LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR 72
            L ME + + L  +V+ L +E+ +  +           +++EK QL+   E L  + E   
Sbjct: 494  LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553

Query: 73   SEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVL 132
              +EQ  E   Q  ++          R+ S I   A        +V +++ E K L   +
Sbjct: 554  KILEQENEHLNQTVSS---------LRQRSQISAEA--------RVKDIEKENKILHESI 596

Query: 133  TNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
              T S   +L+ +  E ++I + +E          KE   R   L  +   LE+EN  LQ
Sbjct: 597  KETSS---KLSKIEFEKRQIKKELE--------HYKEKGERAEELENELHHLEKENELLQ 645

Query: 193  KQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTERE 252
            K+++ L+    + E L+ E   LE E   L   L+        S + L   LE+L+ E  
Sbjct: 646  KKITNLKITCEKIEALEQENSELERENRKLKKTLD--------SFKNLTFQLESLEKENS 697

Query: 253  QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE-----HGG 307
            Q +    EL   +            + L+  +   +  +     E L   F+        
Sbjct: 698  QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757

Query: 308  LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLS--------ELNISEIQKLKQQLMQMEREK 359
               L ++N+      E        L S+L          + N+ E++   ++L Q+E+E 
Sbjct: 758  YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817

Query: 360  AGL---LATLQDTQKQLEHTRGSLSEQQE-KVTRLTENLSALRRLQASKERQTALDNEKD 415
              L    + L+  +KQLE     L +Q E K T L EN   +  L+  KE +T       
Sbjct: 818  KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE--KENKTL------ 869

Query: 416  RDSHEDGDYYEVDINGPEI------LACKYHVAVAEAGELREQLKALRSTHEAREAQHAE 469
              S E G Y E  +   E+      L  +  + +     LRE L  +    + ++  +  
Sbjct: 870  --SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDL 925

Query: 470  EKGRYEAEGQALTEKVSLLEKASRQD---RELLARLEKELKKVSDVAGETQGSLSVAQDE 526
            EK  +E E   L ++  L ++ S  D   + L ++LE  LKK  ++  E   +L    +E
Sbjct: 926  EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985

Query: 527  LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILL 586
               ++++L            +    V  +Y    Q          R   E   + SP   
Sbjct: 986  STNYNQQL-----------RQELKTVKKNYEALKQ----------RQDEERMVQSSP--- 1021

Query: 587  PKGLLAPEAGRADGGTGDSSPSPGSSL--PSPLSDPRREPMNIYNLIAIIRDQIKHLQAA 644
                  P +G  +    +S  +    L     L +  R    +      ++ Q+K L+  
Sbjct: 1022 ------PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET- 1074

Query: 645  VDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTA 704
              +   L  Q +A Q    ++ +    L  +  KL+   ST   Q T+L        Q A
Sbjct: 1075 --QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM------NQNA 1126

Query: 705  EVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEM 764
            ++ +   +S  ENE   V +    L++   +L +D      L    A+  +  I++   +
Sbjct: 1127 QLLIQ--QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184

Query: 765  QRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
            +      E E + L       ++QK  L    ++L+++ E+
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1225



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 161/847 (19%), Positives = 325/847 (38%), Gaps = 79/847 (9%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLKLQFEEL 64
            E  E    ++E + E L   V  L      +   +++  E    +L E   +   +  ++
Sbjct: 547  ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606

Query: 65   EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV------ 118
            E +   I+ E+E  KE   +A     ++      +E  L+Q+  +  +    K+      
Sbjct: 607  EFEKRQIKKELEHYKEKGERAEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQE 664

Query: 119  -LELQTELKQLRNVLTNTQSENERLASVAQELKEINQ-NVEIQRGRLRDDIKEYKFREAR 176
              EL+ E ++L+  L + ++   +L S+ +E  ++++ N+E++R    + +K    + A+
Sbjct: 665  NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV--ESLKCASMKMAQ 722

Query: 177  LLQDYSELEEENISLQKQVSVLRQN-------QVEFEGLKHEIKRLEEETEYLNS---QL 226
            L  +  ELE E   L+K + +L+ +       +V ++GL  E +RL++  E  N    QL
Sbjct: 723  LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782

Query: 227  EDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
            E  ++  E+  + L++ LE LK   ++   L KE       N S       +  D  +  
Sbjct: 783  ESELQDLEMENQTLQKNLEELKISSKRLEQLEKE-------NKSLEQETSQLEKDKKQLE 835

Query: 287  DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE-GLAPPSPSLVSDLLSELNISEI 345
             +       AE      E   +    L+ +  T  KE G+   S          + + E+
Sbjct: 836  KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC---------VRLKEL 886

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K  ++L++        L TL++     +     ++   EK+T   E +   +      E
Sbjct: 887  EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946

Query: 406  RQTALDNEKDRDSHEDGDYYE-VDINGPEILACKYHVAVAEA--GELREQLKALRSTHEA 462
            + T     K  +S  +    + ++I   +I A +  +  +     +LR++LK ++  +EA
Sbjct: 947  QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006

Query: 463  REAQHAEEK------------GRYEAEGQALTEKV----SLLEKASRQDRELLAR---LE 503
             + +  EE+             ++E E Q  T ++      L +  R +  L A    L+
Sbjct: 1007 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066

Query: 504  KELKKVSDVAGETQGSLSVAQDELVTFSEELANL--YHHVCMCNNETPNRVMLDYYREGQ 561
             +LK++       Q  +   Q + V+  E+   L   +      N T N        +  
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126

Query: 562  GGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPR 621
                + S     +      R  +      L  +  + +    +   S   SL S     +
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-LLHERQASEYESLISKHGTLK 1185

Query: 622  REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKS 681
                N+      + D+   L     +  +L +     QE     +K+ E +  E  K   
Sbjct: 1186 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK--- 1242

Query: 682  LLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAA 741
             L  + +++    + L    +  +    NLKS   N K   T    +L  E   LKE   
Sbjct: 1243 -LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT----RLEAEFSKLKEQYQ 1297

Query: 742  TFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLEL 801
                       +C+     L +++  L   E+ +  L+ +  + +Q +  L Q +E  +L
Sbjct: 1298 QLDITSTKLNNQCE----LLSQLKGNL--EEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351

Query: 802  DHEQTRR 808
             H + R+
Sbjct: 1352 FHVEQRQ 1358



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 163/834 (19%), Positives = 324/834 (38%), Gaps = 178/834 (21%)

Query: 25   EVKRLSHELAETTR---EKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
            E K +  +  E TR   +K+   E      +E  QLK +  ++E++ +  R ++E+L E 
Sbjct: 358  ETKTMLEDQLEGTRARSDKLHELE------KENLQLKAKLHDMEMERDMDRKKIEELME- 410

Query: 82   FGQAHTNHKKVAADGESREESL--------------IQESASK------EQYYVRKVLEL 121
                  N     A  +S +ESL              + E+  K       +    ++L+L
Sbjct: 411  -----ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465

Query: 122  QTE-------LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
            + E       +++LR  + + +    ++  + +E + +++ VEI    L ++I + K   
Sbjct: 466  EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI----LENEIVQEKQSL 521

Query: 175  ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLN---------SQ 225
                    +L +E   L+K +  LR+N       + +IK LE+E E+LN         SQ
Sbjct: 522  QNCQNLSKDLMKEKAQLEKTIETLRENS------ERQIKILEQENEHLNQTVSSLRQRSQ 575

Query: 226  LEDAIRLKEISE------RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
            +    R+K+I +        ++E    L     +K  ++KEL HY               
Sbjct: 576  ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY--------------- 620

Query: 280  LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
                       E    AE L N   H     L  +N+    K   L             +
Sbjct: 621  ----------KEKGERAEELENELHH-----LEKENELLQKKITNL-------------K 652

Query: 340  LNISEIQKLKQQLMQMEREKAGLLATLQDTQ------KQLEHTRGSLSEQQEKVTRLTEN 393
            +   +I+ L+Q+  ++ERE   L  TL   +      + LE     L E+  ++ R  E+
Sbjct: 653  ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712

Query: 394  L--SALRRLQASKERQTALDNEKD---------RDSHEDGDYYEVDINGPEILACKYHVA 442
            L  ++++  Q   E +  L++EK+         + S +  +  EV   G +I   +    
Sbjct: 713  LKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771

Query: 443  VAEAG----ELREQLKALRSTHEAREAQHAEEK------GRYEAEGQALTEKVSLLEKAS 492
            +  +     +L  +L+ L   ++  +    E K       + E E ++L ++ S LEK  
Sbjct: 772  LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831

Query: 493  RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV 552
            +Q  +   RL ++ +       E    +   + E  T S+E+  +Y   C+   E     
Sbjct: 832  KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-GIYKESCVRLKELE--- 887

Query: 553  MLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSS 612
                 +E +    R +   +T    R      L+ + L   +               G +
Sbjct: 888  -----KENKELVKRATIDIKTLVTLR----EDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938

Query: 613  LPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEAL 672
                L D +    + Y L+         L++ + ++ E+  ++IA+           EA 
Sbjct: 939  KERLLHDEQSTDDSRYKLLE------SKLESTLKKSLEIKEEKIAA----------LEAR 982

Query: 673  MEEILKLKSLLSTKREQITTLRTVLKANKQ--------TAEVALANLKSKYENEKAMVTE 724
            +EE       L   R+++ T++   +A KQ         +   ++   +K+E E    T 
Sbjct: 983  LEESTNYNQQL---RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1039

Query: 725  TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTL 778
             ++K+++ L  ++ + AT  + +    T+  +  TQ + +Q Q+ A + +  +L
Sbjct: 1040 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1093



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 162/788 (20%), Positives = 312/788 (39%), Gaps = 119/788 (15%)

Query: 94  ADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEIN 153
           AD +++   L QE   K +    ++L+ + EL+Q+   L   Q EN  L S A+  +   
Sbjct: 254 ADAKAKIRRLRQELEEKTE----QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309

Query: 154 QNVEIQR------GRLRDDIKEYK-------FREARLLQDYSELEEENISLQKQVSVLRQ 200
             ++  R       +L  ++  YK       F +AR+     EL+E+N  L +  ++L  
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARV----EELKEDNQVLLETKTMLED 365

Query: 201 NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL-ETLKTEREQKNSLRK 259
                     ++  LE+E   L ++L D    +++  +++EE + E +  E  QK S+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425

Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE-PNNDAEALVNGFEHGGLAKLPLDNKTS 318
            L             HL   L+ +  + + +E P       VN      L KL ++N++ 
Sbjct: 426 SL-------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 319 TPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQLMQMEREKAGLLATLQDTQK------ 371
           T   E L     S+  +    L +  E Q+L +++  +E E      +LQ+ Q       
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532

Query: 372 ----QLEHTRGSLSEQQEKVTR--------LTENLSALR-RLQASKERQTALDNEKDRDS 418
               QLE T  +L E  E+  +        L + +S+LR R Q S E +     ++++  
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592

Query: 419 HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
           HE        ++  E           E  +++++L+  +   E R  +   E    E E 
Sbjct: 593 HESIKETSSKLSKIEF----------EKRQIKKELEHYKEKGE-RAEELENELHHLEKEN 641

Query: 479 QALTEKVSLLE------KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE 532
           + L +K++ L+      +A  Q+   L R  ++LKK  D        L   + E     E
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 533 ELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
           E   L  +V    C +    ++ L+  +E +    +   G      +  +   + +    
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
           L  E  R    T ++S      L S L D   E          ++  ++ L+ +  R  +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQT-------LQKNLEELKISSKRLEQ 812

Query: 651 LSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTK------------------------ 686
           L ++  + ++    ++KDK+ L +E  +L+     K                        
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872

Query: 687 ----REQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETM--MKLRNELKALKEDA 740
               +E    L+ + K NK+  + A  ++K+     + +V+E +   ++ N+L+ L  + 
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932

Query: 741 ATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
                 +       DE  T  D+ + +L  ++ E  TL   L +  ++  AL  RLE   
Sbjct: 933 EKIGLNKERLLH--DEQST--DDSRYKLLESKLE-STLKKSLEIKEEKIAALEARLEEST 987

Query: 801 LDHEQTRR 808
             ++Q R+
Sbjct: 988 NYNQQLRQ 995



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 60/260 (23%), Positives = 112/260 (43%), Gaps = 36/260 (13%)

Query: 31   HELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQA----- 85
            HE  E   E+ QA+EY  +++ +   LK   + LEV++  +     QL +  GQ      
Sbjct: 1160 HEKLELLHER-QASEYE-SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217

Query: 86   ------------HTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRN 130
                        + NH+ VAA+     + L  E+      Y + + E   LQT+ K L++
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273

Query: 131  VLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
            +L N++ E  RL +   +LKE  Q ++I   +L +  +     +  L ++   L ++  +
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333

Query: 191  LQKQVSVLRQNQVEFEGLKH--------EIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
            L  Q   L +  +E + L H        ++  L  + E L  ++ D  +  + S  +   
Sbjct: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1393

Query: 243  ALETLKTER--EQKNSLRKE 260
               TLK  +  + K  + +E
Sbjct: 1394 NWITLKMRKLIKSKKDINRE 1413


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 186/910 (20%), Positives = 336/910 (36%), Gaps = 145/910 (15%)

Query: 16   EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
            E +   ++ E ++   ELA++  ++ +  E  + +++EK+ L+LQ +    +        
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906

Query: 76   EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
            +QL +A  Q     K+V    E  EE +  E  +K++    +  EL+ ++  L   L   
Sbjct: 907  DQLIKAKFQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 965

Query: 136  QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
            + E     +  + L E    ++    +L  + K  +    + L D    E++  SL K  
Sbjct: 966  EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025

Query: 196  SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQLEEALE--- 245
            S L Q   + E    + K+L  + E    +LE  ++L + S       ++QL+E L+   
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085

Query: 246  ------TLKTEREQKNSLR-----KEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN 293
                    K E EQ   L+     KEL +    + +         +    + SD A E  
Sbjct: 1086 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145

Query: 294  NDAEAL------------VNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL- 340
              +E L            +N        KL  D + +T + E +        +D ++EL 
Sbjct: 1146 ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELG 1205

Query: 341  -NISEIQKLKQQLMQ------------------MEREKAGLLATLQDTQKQLEHTRGSLS 381
              I  +Q++KQ+L +                  + + KA L    +  + QL   RG   
Sbjct: 1206 EQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 1265

Query: 382  EQQEKVTRLT------------------ENLSALRRLQASKERQTALDNEKDRDSHEDG- 422
            E Q  ++ LT                  E  S + +L  SK+  T    E  R   E+  
Sbjct: 1266 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325

Query: 423  --------------------DYYEVDINGPEILACKYHVAVAEAGELREQLK--ALRSTH 460
                                + YE +  G   L      A +E  + R + +  A++ T 
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1385

Query: 461  EAREAQH--AEEKGRYEAEGQALTEKVSLLEKASR--------------QDRELLARLEK 504
            E  EA+   A+     E + +A+  K + LEK  +              +   L A L+K
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445

Query: 505  ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNN---------ETPNRVMLD 555
            + +    V  E +     +Q EL    +E  +L   +    N         ET  R   +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505

Query: 556  YYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
              +E      + +  G+T  E    R  I L K  +      A+    +   +    +  
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL-EHEEAKILRIQL 1564

Query: 616  PLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEE 675
             L+  + E   I   IA   ++I+ L+    RT E  +          A+D +  +   E
Sbjct: 1565 ELTQVKSE---IDRKIAEKDEEIEQLKRNYQRTVETMQS---------ALDAEVRS-RNE 1611

Query: 676  ILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
             ++LK  +     +I     +  AN+Q AE  L +L+S     +  + +T + L + L+ 
Sbjct: 1612 AIRLKKKMEGDLNEIEI--QLSHANRQAAE-TLKHLRS----VQGQLKDTQLHLDDALRG 1664

Query: 736  ---LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL 792
               LKE  A       +     +E    L++ +R    AE E    N  +++   Q  +L
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724

Query: 793  TQRLELLELD 802
                + LE D
Sbjct: 1725 IHTKKKLETD 1734



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 120/576 (20%), Positives = 237/576 (41%), Gaps = 83/576 (14%)

Query: 9    EYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDY 68
            E A L  EA    LR +      EL E   + +Q  +  L   +EK + KL+ ++L    
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQI-DNLQRVKQKLE--KEKSEFKLEIDDLSSSM 1236

Query: 69   EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
            E++      L++          +     E  + SL + +  K +    +  EL  +L++ 
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT-EAGELSRQLEEK 1295

Query: 129  RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
             ++++      +      +ELK   +     +  L   ++  +     L + Y E +E  
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355

Query: 189  ISLQKQVSVLRQNQVEFEGLKHEI------KRLEEETEYLNSQLED------AIRLK--- 233
              LQ+ +S       ++   K+E       + LEE  + L  +L+D      A+  K   
Sbjct: 1356 AELQRALSKANSEVAQWR-TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414

Query: 234  -EISERQLEEALETLKTEREQKNSLRKELSHYMSINDSF---YTSHLHVSLDGLKFS-DD 288
             E ++++L+  +E L  + E+ NSL   L       D     + +    S   L+ S  +
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474

Query: 289  AAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL--NISEIQ 346
            +   + +   L N +E        LD +  T K+E         ++DL  ++  N   I 
Sbjct: 1475 SRSLSTELFKLKNAYEEA------LD-QLETVKRENKNLEQE--IADLTEQIAENGKTIH 1525

Query: 347  KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL-----------SEQQEKVTRLTENLS 395
            +L++   Q+E EKA +   L++ +  LEH    +           SE   K+    E + 
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585

Query: 396  ALRR--LQASKERQTALDNEKDRDSHE--------DGDYYEVDINGPEILACKYHVAVAE 445
             L+R   +  +  Q+ALD E  R  +E        +GD  E++I             ++ 
Sbjct: 1586 QLKRNYQRTVETMQSALDAEV-RSRNEAIRLKKKMEGDLNEIEIQ------------LSH 1632

Query: 446  AG-ELREQLKALRSTH-EAREAQ-HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARL 502
            A  +  E LK LRS   + ++ Q H ++  R + +   L E+++++E+ +         L
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED---LKEQLAIVERRAN-------LL 1682

Query: 503  EKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
            + E++++     +T+ +  +A+ EL+  +E +  L+
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 115/511 (22%), Positives = 212/511 (41%), Gaps = 84/511 (16%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
            E L    K+L+  L ++  E+++A     A LE+ K +L+ + E+L VD E   S    L
Sbjct: 1385 EELEEAKKKLAQRLQDS-EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS----L 1439

Query: 79   KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
              A  +   N  KV A+ +++ E    ES ++ +  +++   L TEL +L+N        
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCE----ESQAELEASLKESRSLSTELFKLKNAY------ 1489

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
             E      + +K  N+N+E                     Q+ ++L E+     K +  L
Sbjct: 1490 -EEALDQLETVKRENKNLE---------------------QEIADLTEQIAENGKTIHEL 1527

Query: 199  RQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLR 258
             +++ + E  K +I+   EE E        A+  +E    +++  L  +K+E ++K + +
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEA-------ALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580

Query: 259  KELSHYMSINDSFYTSHLHVSLDG-LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT 317
             E    +  N       +  +LD  ++  ++A       E  +N  E     +L   N+ 
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE----IQLSHANRQ 1636

Query: 318  STPKKEGLAPPSPSLVSDLLSELNISEI----QKLKQQLMQMER-------EKAGLLATL 366
            +    + L      L     ++L++ +     + LK+QL  +ER       E   L ATL
Sbjct: 1637 AAETLKHLRSVQGQLKD---TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693

Query: 367  QDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQASKERQTALDNEKDRDSHEDGDYY 425
            + T++  +     L +  E+V  L T+N S +   +  +     L +E +  S +  +  
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAE 1753

Query: 426  EVDINGPEILACKYHVAVAEAGELREQLKALRST--HEAREAQHAEEKGR------YEAE 477
            E           K   A+ +A  + E+LK  + T  H  R  ++ E+  +       EAE
Sbjct: 1754 E-----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802

Query: 478  GQALTEKVSLLEKASRQDRELLARLEKELKK 508
              AL      ++K   + REL   LE E KK
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKK 1833



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 114/640 (17%), Positives = 234/640 (36%), Gaps = 77/640 (12%)

Query: 192  QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
            +K+++ +++   EF+  K E+ + E + + L  +L   ++ K   + Q++   E L    
Sbjct: 847  EKEMATMKE---EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 252  EQ-------KNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE 304
            E+       K  L  ++       +     +  ++    K  D+ +E   D + L     
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL----- 958

Query: 305  HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLA 364
               LAK+  +   +  K + L      L      +  I+++ + K+ L +  ++    L 
Sbjct: 959  ELTLAKVEKEKHATENKVKNLTEELSGL------DETIAKLTREKKALQEAHQQALDDLQ 1012

Query: 365  TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR----RLQASKERQTALDNEKDRDSHE 420
              +D    L  T+  L +Q E +    E    LR    R +   E    L  E   D   
Sbjct: 1013 AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072

Query: 421  DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
            D    +  +   +   C+    V +     EQ   L+   + +E Q   E+   E E + 
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVED-----EQTLGLQFQKKIKELQARIEELEEEIEAER 1127

Query: 481  LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE-----ELA 535
             T       K  +Q  +    LE+  +++ +  G T   + + +     F +     E A
Sbjct: 1128 ATRA-----KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182

Query: 536  NLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEA 595
             L H   +      +             A   +  G      +  +  +   K     E 
Sbjct: 1183 TLQHEAMVAALRKKH-------------ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229

Query: 596  GRADGGTGDSSPSPGS------SLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
                      S S  +      +L   LS+ R +   I   ++ +  Q   LQ       
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG--- 1286

Query: 650  ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALA 709
            ELSRQ    + +   + + K+A  ++  +LK  L  + +    L   L++++   ++   
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL--- 1343

Query: 710  NLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLA 769
             L+ +YE E+    E         +AL +  +  +  R  + T   +   +L+E +++LA
Sbjct: 1344 -LREQYEEEQEGKAELQ-------RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395

Query: 770  A----AEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
                 +E++ + +N+      + K  L   +E L +D E+
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 47/215 (21%), Positives = 95/215 (44%), Gaps = 19/215 (8%)

Query: 51   LEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK 110
            L  +  LK Q   +E     +++E+E+L+    Q     K         E+ L+  +   
Sbjct: 1662 LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA-------EQELLDSNERV 1714

Query: 111  EQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEY 170
            +  + +    + T+ K+L   L   QSE E  +  A+  +E  +        + +++K+ 
Sbjct: 1715 QLLHTQNTSLIHTK-KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773

Query: 171  KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE--- 227
            +   A L +    LE+    LQ ++      Q+  +G K +I++LE     L  +LE   
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQHRLD--EAEQLALKGGKKQIQKLETRIRELEFELEGEQ 1831

Query: 228  ----DAIRLKEISERQLEEALETLKTEREQKNSLR 258
                ++++     ER+++E   T ++E ++KN LR
Sbjct: 1832 KKNTESVKGLRKYERRVKEL--TYQSEEDRKNVLR 1864



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 85/422 (20%), Positives = 175/422 (41%), Gaps = 51/422 (12%)

Query: 3    APSEEEEYARLVMEAQPEWLRAEVKRL----SHELAETTREKIQAAEYGLAVLEEKHQLK 58
            A  E EE   L ++ +   +++E+ R       E+ +  R   +  E   + L+ + + +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609

Query: 59   LQFEELEVDYEAIRSEME-QLKEAFGQAHTNHKKV-AADGESREESLIQESASKEQYYVR 116
             +   L+   E   +E+E QL  A  QA    K + +  G+ ++  L  + A + Q  ++
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK 1669

Query: 117  KVLE--------LQTELKQLRNVLTNTQSENERLASVA-QELKEINQNVEIQRGRLRDDI 167
            + L         LQ E+++LR  L  T    ER   +A QEL + N+ V++   +    I
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQT----ERARKLAEQELLDSNERVQLLHTQNTSLI 1725

Query: 168  KEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE 227
               K  E  L+Q  SE+E+ +   +      ++   +   +  E+K+ ++ + +L    +
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785

Query: 228  DAIRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
            +  +  +  + +L+EA +  LK  ++Q   L   +              L   L+G    
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI------------RELEFELEG---- 1829

Query: 287  DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ 346
                E   + E+ V G          L  ++   +K  L       + DL+ +L + +++
Sbjct: 1830 ----EQKKNTES-VKGLRKYERRVKELTYQSEEDRKNVLR------LQDLVDKLQV-KVK 1877

Query: 347  KLKQQLMQMEREKAGLLATLQDTQKQLEHT--RGSLSEQQ-EKVTRLTENLSALRRLQAS 403
              K+Q  + + +    L   +  Q +LE    R  ++E Q  K+   T + ++ R +   
Sbjct: 1878 SYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937

Query: 404  KE 405
             E
Sbjct: 1938 SE 1939



 Score = 33.5 bits (75), Expect = 0.83
 Identities = 41/184 (22%), Positives = 71/184 (38%), Gaps = 35/184 (19%)

Query: 354 QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE 413
           + E+E A +    Q T+ +L  +     E +EK+  L +  + L+ LQ   E +  LD E
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ-LQVQAESENLLDAE 903

Query: 414 KDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGR 473
           +  D               +++  K+        +L  ++K +    E  E  +AE    
Sbjct: 904 ERCD---------------QLIKAKF--------QLEAKIKEVTERAEDEEEINAE---- 936

Query: 474 YEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
                  LT K   LE    + ++ +  LE  L KV      T+  +    +EL    E 
Sbjct: 937 -------LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989

Query: 534 LANL 537
           +A L
Sbjct: 990 IAKL 993


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 176/863 (20%), Positives = 348/863 (40%), Gaps = 97/863 (11%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQA------------AEYGLAVLEE 53
            EEE   +  +E      ++ +  L  +LA   +E  +              +  L++L+E
Sbjct: 446  EEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505

Query: 54   KHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQY 113
               L+   E+LEV     + E+  LKE FG     H+K     E +      E  SKE  
Sbjct: 506  ISSLQ---EKLEVTRTDHQREITSLKEHFGAREETHQK-----EIKALYTATEKLSKENE 557

Query: 114  YVRKVLELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
             ++  LE     K+  +V+   +S+ E  +AS  Q ++E+  +     G    +  E K 
Sbjct: 558  SLKSKLEHAN--KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 615

Query: 173  REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE----IKRLEEETEYLNSQLED 228
            +  ++  DY   E EN+  Q Q S    +  E E L+ +    IK  E   E + S+L+ 
Sbjct: 616  QIEKMRLDYQH-EIENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673

Query: 229  AIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLH------VSLDG 282
            A     +        L+  + + ++   L+ + +    + D+F TS L       + LD 
Sbjct: 674  AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF-TSQLKATEEKLLDLDA 732

Query: 283  LKFSDDAAEP-----NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
            L+ +    +          EA     +H  + K    +K S+  +E        L    L
Sbjct: 733  LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE---LQGRELKLTNL 789

Query: 338  SELNISEIQKLKQQL---MQMEREK-AGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTEN 393
             E N+SE+ ++K+ L   +Q+ +EK A         Q+ ++ T   L +++E+   L+ +
Sbjct: 790  QE-NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848

Query: 394  LSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI---------NGPEILACKYHVAVA 444
            L  LR   A  E +    +E++    +  +  E DI         N  ++      + + 
Sbjct: 849  LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908

Query: 445  EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
            E      QLK  ++   A   Q + E    +AE Q+  E     E+  ++    L+ LEK
Sbjct: 909  ERDVEELQLKLTKANENASFLQKSIEDMTVKAE-QSQQEAAKKHEEEKKELERKLSDLEK 967

Query: 505  ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
            +++   +   E +     A  E  T  EE+            +   + +LD   + +G  
Sbjct: 968  KMETSHNQCQELKARYERATSETKTKHEEIL-----------QNLQKTLLDTEDKLKGAR 1016

Query: 565  GRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREP 624
               S   +   E R +       K   A  A  A       +     +L S L D ++  
Sbjct: 1017 EENSGLLQELEELRKQAD-----KAKAAQTAEDAMQIMEQMTKEKTETLAS-LEDTKQTN 1070

Query: 625  MNIYNLIAIIRD-QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
              + N +  +++  +K+++       EL++    S+EL    ++  E   +EI  LK   
Sbjct: 1071 AKLQNELDTLKENNLKNVE-------ELNK----SKELLTVENQKMEEFRKEIETLKQAA 1119

Query: 684  STKREQITTLR--TVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNE----LKALK 737
            + K +Q++ L+   V  A +            K E E++++   +++++      +K   
Sbjct: 1120 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179

Query: 738  EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK---KTLNSLLRMAIQQKLALTQ 794
            E+ A+     ++ +    E   +L++++ ++     E    K+L+S+++     K+ L  
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1239

Query: 795  RLELLELDHEQTRRGRAKAAPKT 817
            +++ LEL  ++ +R  + ++  T
Sbjct: 1240 KVKNLELQLKENKRQLSSSSGNT 1262



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 160/797 (20%), Positives = 328/797 (41%), Gaps = 97/797 (12%)

Query: 69   EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
            EA++ + + +++   +      +VA    S    + QE A     + + VLEL+ ++ QL
Sbjct: 355  EALKEKQQHIEQLLAERDLERAEVAK-ATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413

Query: 129  RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
            R ++     E   L +   +L+E  + VE  + R+ ++       E   + + S + E  
Sbjct: 414  RTMVEAADREKVELLN---QLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIME-- 468

Query: 189  ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
              L+K +++  Q   E        +RLE      +  +  ++ L+EIS   L+E LE  +
Sbjct: 469  --LEKDLALRVQEVAELR------RRLESNKPAGDVDMSLSL-LQEIS--SLQEKLEVTR 517

Query: 249  TEREQK-NSLR-----KELSHYMSINDSFYTSHLHVSLDGLKFS---DDAAEPNNDAEAL 299
            T+ +++  SL+     +E +H   I  + YT+   +S +        + A + N+D  AL
Sbjct: 518  TDHQREITSLKEHFGAREETHQKEIK-ALYTATEKLSKENESLKSKLEHANKENSDVIAL 576

Query: 300  VNGFEHGGLA---KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNIS---EIQKLKQQ-- 351
                    +A   +   + K S  K  G      + +   + ++ +    EI+ L+ Q  
Sbjct: 577  WKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD 636

Query: 352  ------LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-- 403
                    +ME  +A L+  +++ +  LE  R  L + +++   L E    L +LQ +  
Sbjct: 637  SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ--HLVEMEDTLNKLQEAEI 694

Query: 404  KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR 463
            K ++  +   K  +  +  D +   +   E            + E + ++K LR   EA 
Sbjct: 695  KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 754

Query: 464  EAQ--HAE-EKGRYEAEGQALTEKVSLLEKASRQDREL-LARLEKELKKVSDVAGETQGS 519
            E Q  H E EK    ++  ++T ++        Q REL L  L++ L +VS V    +  
Sbjct: 755  EKQIKHLEIEKNAESSKASSITREL--------QGRELKLTNLQENLSEVSQVKETLEKE 806

Query: 520  LSVAQDELVTFSEELANLYHHVCMCNN------ETPNRVMLDYYREGQGGAGRTSPGGRT 573
            L + +++    SEE  ++   +    N      E  N +  D  +  +  A   +     
Sbjct: 807  LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA----K 862

Query: 574  SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAI 633
              E   R   ++  K  L  +       +GD+S S  + +   L    R+   +   +  
Sbjct: 863  FREKDEREEQLIKAKEKLENDIAEIMKMSGDNS-SQLTKMNDELRLKERDVEELQLKLTK 921

Query: 634  IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
              +    LQ +++  T  + Q  + QE     +++K+ L  ++  L+  + T   Q   L
Sbjct: 922  ANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979

Query: 694  RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF---------S 744
                   K   E A +  K+K+E     + +T++   ++LK  +E+ +            
Sbjct: 980  -------KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ 1032

Query: 745  SLRAMFATRCDEYITQLDEMQRQ----LAAAEDEKKT-------LNSLLRMAIQQKLALT 793
            + +A  A   ++ +  +++M ++    LA+ ED K+T       L++L    ++    L 
Sbjct: 1033 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1092

Query: 794  QRLELLELDHEQTRRGR 810
            +  ELL +++++    R
Sbjct: 1093 KSKELLTVENQKMEEFR 1109



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 93/450 (20%), Positives = 187/450 (41%), Gaps = 39/450 (8%)

Query: 379 SLSEQQEKVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILAC 437
           S+S +  +   LTE  S   R++  +   Q AL   K++  H +    E D+   E+   
Sbjct: 325 SVSSRPSRTGLLTETSSRYARKISGTTALQEAL---KEKQQHIEQLLAERDLERAEVAKA 381

Query: 438 KYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRE 497
             HV     GE+ ++L   R  H+    QH  E    EA+   L    +++E A R+  E
Sbjct: 382 TSHV-----GEIEQELALARDGHD----QHVLE---LEAKMDQLR---TMVEAADREKVE 426

Query: 498 LLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYY 557
           LL +LE+E +KV D+         V ++ +     E+A +     +   E    + +   
Sbjct: 427 LLNQLEEEKRKVEDL------QFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV 480

Query: 558 REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
            E +       P G         +    L + L   E  R D     +S        +  
Sbjct: 481 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKL---EVTRTDHQREITSLK--EHFGARE 535

Query: 618 SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPAVDKDKEALMEE 675
              ++E   +Y     +  + + L++ ++   + +   IA    +L  A+   ++A+ E 
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595

Query: 676 ILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL-K 734
            +     L T+  +   L+T ++  +   +  + NL+++ ++E+A   + M  LR +L K
Sbjct: 596 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMK 655

Query: 735 ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL-- 792
            +KE   +  ++R+      D+++ ++++   +L  AE + K L  L     +Q   +  
Sbjct: 656 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 715

Query: 793 -TQRLELLE---LDHEQTRRGRAKAAPKTK 818
            T +L+  E   LD +  R+  ++   + K
Sbjct: 716 FTSQLKATEEKLLDLDALRKASSEGKSEMK 745


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 109/546 (19%), Positives = 223/546 (40%), Gaps = 68/546 (12%)

Query: 2   SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
           S   E +E   ++ E   + +  E K L  +   TT +K+   E    ++++  ++K   
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL-LGELQEQIVQKNQEIKNMK 377

Query: 62  EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
            EL    +  R   E++K+  G      K+   D +  E  ++Q    + Q   RK+ +L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF-ETDIVQRMEQETQ---RKLEQL 433

Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
           + EL ++       Q    +   + Q + ++ +     +G + + ++ Y    + +  + 
Sbjct: 434 RAELDEMYG----QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY----SNITVNE 485

Query: 182 SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
            +++  N+++ +    L+    + E LK E+  + EE   L  QLED +     S  Q++
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545

Query: 242 EALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVN 301
            A +T+  +  + N   K LS    +     ++           S+   E     EA V 
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA-----------SESRKELELKHEAEVT 594

Query: 302 GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
            ++     KL +  K      + +A    + +  L ++L  S  ++L +    +E E   
Sbjct: 595 NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI 650

Query: 362 LLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDR 416
            +  L+D      ++Q++  +  +S++ E +    +NL        +K+ Q  L+  K +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-------ITKQNQLILEISKLK 703

Query: 417 DSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
           D  +             ++  K      +  EL+++++ LR        Q  +EKG  E 
Sbjct: 704 DLQQS------------LVNSKSEEMTLQINELQKEIEILR--------QEEKEKGTLEQ 743

Query: 477 EGQALTEKVSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSLS----VAQDELV 528
           E Q L  K  LLEK  ++     +E  A+LE E   + D     +  L     V+Q+E +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERL 803

Query: 529 TFSEEL 534
            F + +
Sbjct: 804 IFLDSI 809



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 148/766 (19%), Positives = 320/766 (41%), Gaps = 82/766 (10%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
            V E Q + +   +  L+ +L +T  +K +  E    +LEEK  L+ Q E+L  +    R 
Sbjct: 483  VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 74   EMEQLKEAFGQAHTN----HK----------KVAADGESREESLIQESASKEQYYVRKVL 119
            ++++ ++   +  +     HK          ++ +  ESR+E  ++  A    Y ++  +
Sbjct: 543  QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 120  ELQTELKQLRNVLTNTQSENERLA-----SVAQELKEINQNVEIQR----GRLRDDIKEY 170
              + +   L  +  + ++E ERL      S  +EL ++ +++EI+      +L+D++  +
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 171  KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE-ETEYLNSQLEDA 229
              ++   LQ+    + E +  +K   + +QNQ     L  EI +L++ +   +NS+ E+ 
Sbjct: 663  YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ-----LILEISKLKDLQQSLVNSKSEE- 716

Query: 230  IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSD 287
                 +   +L++ +E L+ E ++K +L +E+   + +        +    + L  KF+ 
Sbjct: 717  ---MTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772

Query: 288  DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK 347
              AE N+  +      E       P+  +      + +   S   V +   E+ I E + 
Sbjct: 773  LEAE-NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831

Query: 348  LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQ 407
            LKQQ +Q+  E      T    +K  E     L E+   + ++ ++      L+ SK +Q
Sbjct: 832  LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD------LEDSKNKQ 885

Query: 408  TALDNEKDRDSHEDGDYYEVDINGPEILACKY---HVAVAEAGELREQLKALRSTHEARE 464
                  K +  +E+     ++    ++ +  +      VAE  E+ E ++  + T E  E
Sbjct: 886  ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--KDTTELME 943

Query: 465  AQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
                 ++ + E     L++++S L +  +Q    ++ L +E+K +     + Q SL   +
Sbjct: 944  KLEVTKREKLE-----LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ--EKEQVSLRCRE 996

Query: 525  DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
             E++       N    V  C+ +  + +        +G  G  S   ++     G  S I
Sbjct: 997  LEIIINHNRAEN----VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEESKI 1048

Query: 585  LLP-----KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK 639
            ++      + +   E  + +    D  PS         + P  E   +   + +++ +  
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP-SENDKLQKELNVLKSEQN 1107

Query: 640  HLQAAVDRTTELSRQRIA-SQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLK 698
             L+       ++  QRI  S      VD+ +E +  E  K K+L S K E I      +K
Sbjct: 1108 DLR------LQMEAQRICLSLVYSTHVDQVREYMENE--KDKALCSLKEELIFAQEEKIK 1159

Query: 699  ANKQTAEVALANLKSKYENEKAMVTETMM-KLRNELKALKEDAATF 743
              ++  ++ L  +K++   ++      ++ KL+   KA+ E+ + F
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ---KAVSEECSYF 1202



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 151/811 (18%), Positives = 341/811 (42%), Gaps = 98/811 (12%)

Query: 26  VKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR-----SEMEQLKE 80
           + +L+  L +  REK +     L + E+  +L++QF++L+   E +R     S    L +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQ 265

Query: 81  AFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT-----ELKQLRNVLTNT 135
           A  Q  T+ +++       ++ L+++   K++ +  ++  LQ      E++Q + V  + 
Sbjct: 266 AKQQILTHQQQL-----EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320

Query: 136 QSENERLASVAQEL-----KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
           + E +   ++ +EL     +E  + +E+ + +L    K     + +++Q   E++   + 
Sbjct: 321 KEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLE 379

Query: 191 LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAI--RLKEISERQLEEALETL- 247
           L       RQ+  E + L   ++ L++   + +SQ E  I  R+++ ++R+LE+    L 
Sbjct: 380 LTNSKQKERQSSEEIKQLMGTVEELQKR-NHKDSQFETDIVQRMEQETQRKLEQLRAELD 438

Query: 248 KTEREQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
           +   +Q   +++EL   +M+  +   T H     + L+ S      N D   L+N     
Sbjct: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-SYSNITVNEDQIKLMN----V 493

Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
            + +L +  + +  +KE L                  E+  + ++   ++R+   L+  L
Sbjct: 494 AINELNIKLQDTNSQKEKLK----------------EELGLILEEKCALQRQLEDLVEEL 537

Query: 367 QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY-- 424
             +++Q++  R +++EQ+ K+    ++LS +  L+A  E  +A ++ K+ +   + +   
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTN 595

Query: 425 --YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
              ++++   E  A    +A ++  EL      L  +HE   ++  E+    E E +   
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED---LEIEHRINI 652

Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
           EK  L +      ++ +  L+ E+ +  +     + +L   Q++L+    +L +L   + 
Sbjct: 653 EK--LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710

Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
              +E     + +  +E +         G    E +     + L   LL  +    +   
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----ELQLKTELLEKQMKEKE--- 763

Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQR------- 655
                          +D + +   +    +I++D+ K L+  +   T +S++        
Sbjct: 764 ---------------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808

Query: 656 IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKY 715
           I S+      +K+ E L+EE   LK       E+I   R      ++  EV    L+ +Y
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868

Query: 716 -------ENEKAMVTETMMKLRNELKALKED---AATFSSLRAMFATRCDEYITQLDEMQ 765
                  ++ +    +  ++ +++LKAL E+        +   M ++  DE  T + E  
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928

Query: 766 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRL 796
                 E +   L   L +  ++KL L+QRL
Sbjct: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRL 959



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 118/551 (21%), Positives = 233/551 (42%), Gaps = 79/551 (14%)

Query: 9    EYARLVMEAQPE--WLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
            ++A+++ E + E   L  +V +L  +L  TT  K         V+EEK++L     +LE 
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK---------VIEEKNEL---IRDLET 2329

Query: 67   DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
              E + S+ E +K        N ++         E L QE A+  Q        L  E  
Sbjct: 2330 QIECLMSDQECVKR-------NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2382

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
             L++ L    +E     ++ Q+++  N+ +      +++ +KE  F+  +L Q+   L+ 
Sbjct: 2383 SLKHQLDVVIAEK---LALEQQVETANEEMTF----MKNVLKETNFKMNQLTQELFSLKR 2435

Query: 187  ENISLQKQVSV-----------LRQNQVEFEGLKHE--IKRLEEETEYLNSQLEDAIRLK 233
            E  S++K  S+           L +++ E E +  E  +K LE +T + + +      + 
Sbjct: 2436 ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII 2495

Query: 234  EISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
             +  R  QLE  +     E  Q     K++         F T  L   +  L+       
Sbjct: 2496 NLETRLLQLESTVSAKDLELTQCYKQIKDMQE----QGQFETEMLQKKIVNLQ----KIV 2547

Query: 292  PNNDAEALVNGFEHGGL---AKLPLDNKT--STPKKEGLAPPSPSLVSDLLSELNISEIQ 346
                A ALV+  +   +   AK   DN+T  S P++  +       ++ L  +   S+I 
Sbjct: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-----LNQLREDELGSDIS 2602

Query: 347  KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER 406
             L  ++ ++E +   +  +L   ++Q+E    ++ E+++K+  L + L    + Q  KE+
Sbjct: 2603 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2662

Query: 407  QTA--------LDNEKDRDSHEDGDYYEVDINGPEILACKYHVA--VAEAGELREQLKAL 456
            + +           E    + E G + E++    E +A K  +A    +A +L+E+L  +
Sbjct: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL-LV 2721

Query: 457  RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASR---QDRELLARLEK-ELKKVSDV 512
            + T+     +   +   + AE +   EK+S+LEK      Q+ +     E   +K    +
Sbjct: 2722 KETNMTSLQKDLSQVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2778

Query: 513  AGETQGSLSVA 523
            A +T G+L ++
Sbjct: 2779 ASQTDGTLKIS 2789



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 158/761 (20%), Positives = 308/761 (40%), Gaps = 128/761 (16%)

Query: 79  KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
           +E FG   +  ++ A D  +  E +  E A K+     ++ EL  EL+++R V   T+  
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQH----EIEELNRELEEMR-VTYGTEG- 189

Query: 139 NERLASVAQELKEINQNVEIQRG---RLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
                   Q+L+E    ++ + G   +L  ++++ +  +   ++++ EL E++  LQ Q 
Sbjct: 190 -------LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242

Query: 196 SVLRQNQV-----------EFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ---LE 241
             L+ ++            +    K +I   +++ E  +  LED  + KE    Q   L+
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302

Query: 242 EALETLKTEREQK--NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--- 296
           E ++  + E+++K  NS ++E+    +I +   T  +      L+  D     +      
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 297 -EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
            E +V   +     KL L N     ++      S   +  L+    + E+QK   +  Q 
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQ------SSEEIKQLMG--TVEELQKRNHKDSQF 414

Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQ-EKVTRLTENLSALRRLQASKERQTALDNEK 414
           E +    +   Q+TQ++LE  R  L E   +++ ++ + L  +R+  A  E        K
Sbjct: 415 ETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKT--RHK 468

Query: 415 DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY 474
               +    Y  + +N  +I     +VA+ E     +   + +   +       EEK   
Sbjct: 469 GEMENALRSYSNITVNEDQIKLM--NVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526

Query: 475 EAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQD---ELVTFS 531
           + + + L E++S   +  ++ R+ +A  E +L        E   SLS  +D   E+V+ S
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLN-------EAHKSLSTVEDLKAEIVSAS 579

Query: 532 EELANL-YHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
           E    L   H     N      ML+  +E      R +       E    R+ +L     
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMAESQEA--ELERLRTQLLF---- 631

Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTT 649
                         S     S L   L    R  +NI  L    +D +  H +  +D   
Sbjct: 632 --------------SHEEELSKLKEDLEIEHR--INIEKL----KDNLGIHYKQQIDGLQ 671

Query: 650 ELSRQRIASQELGPAVDKD-----KEALMEEILKLK----SLLSTKREQITTLRTVLKAN 700
               Q+I + +     +KD     +  L+ EI KLK    SL+++K E++T     L+ N
Sbjct: 672 NEMSQKIETMQF----EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT-----LQIN 722

Query: 701 KQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMFATRCDEYIT 759
           +   E+ +   + K   EK  + + + +L+ + + L K+     + L+  FA        
Sbjct: 723 ELQKEIEILRQEEK---EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA-------- 771

Query: 760 QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
              +++ + +  +DEKKTL  +L+  I   ++  +RL  L+
Sbjct: 772 ---QLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLD 807



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 171/885 (19%), Positives = 340/885 (38%), Gaps = 154/885 (17%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK--HQLK 58
            + A  ++ +  R ++  Q E ++AE   +  +L + T EK+   +  +    EK    L+
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKEKLEVQCQAEKVRDDLQ 2020

Query: 59   LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESASKEQ 112
             Q + LE+D E   S   +L++   + +T    +    ++ E+ L      + E A   +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE 2077

Query: 113  Y----YVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVE---IQRGRLRD 165
            +    + +++ +L+ +LK +      ++ +   +  +A  LKE         + + +L+ 
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137

Query: 166  DIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY-LNS 224
            DI+E         ++  +LE     L++ + V      + E  KH    +E + E  L  
Sbjct: 2138 DIQERN-------EEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEV 2189

Query: 225  QLE---DAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL-HVSL 280
            QL+   DAI  KE     LEE LE  + E E KN   ++L   + I     T+ L  +  
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249

Query: 281  DGLKFSDDAAEPN---NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
            +   F DD  +      +++A+    +H    K          +KE         V+ L 
Sbjct: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF----AQIIQEKEVEIDQLNEQVTKLQ 2305

Query: 338  SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL 397
             +L I+   K+ ++  ++ R+    +  L   Q+ ++  R      +E++ +L E +  L
Sbjct: 2306 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR------EEEIEQLNEVIEKL 2359

Query: 398  RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
            ++  A+  ++T+++                            H    EA  L+ QL  + 
Sbjct: 2360 QQELANIGQKTSMN---------------------------AHSLSEEADSLKHQLDVVI 2392

Query: 458  STHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDREL---LARLEKELKKVSDVAG 514
            +   A E Q        E   + +T   ++L++ + +  +L   L  L++E + V  +  
Sbjct: 2393 AEKLALEQQ-------VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2445

Query: 515  ETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTS 574
              + S++VA D L     EL      V +  +   +     Y++               S
Sbjct: 2446 IPENSVNVAIDHLSKDKPEL-----EVVLTEDALKSLENQTYFK---------------S 2485

Query: 575  PEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE--------PMN 626
             E  G+ S I L   LL  E+      T  +     +     + D + +           
Sbjct: 2486 FEENGKGSIINLETRLLQLES------TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539

Query: 627  IYNLIAIIRDQIKHL---QAAVDRTTELSR-----QRIASQELGPAVDK----DKEALME 674
            I NL  I+ +++      Q  ++   E ++     Q I+S+     +       ++ L  
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599

Query: 675  EILKLKSLLSTKREQITTLRTVLKANKQTAEVALANL------------------KSKYE 716
            +I  L   +S    Q+  + T L   K+  E+A  N+                  K + E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659

Query: 717  NEKAMVTE--TMMKLRNELKALKEDAATFSSLRAM----FATRCD--EYITQLDEMQRQL 768
             EK    +   ++K   EL    E++  F+ L A+     AT+ +   Y  + +++Q +L
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2719

Query: 769  AAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
               E    +L   L           ++L +LE + E   +   KA
Sbjct: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2764



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 91/406 (22%), Positives = 158/406 (38%), Gaps = 43/406 (10%)

Query: 65   EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRKVLELQT 123
            + D  ++ SE++ L      A  N +K+    E   E   QE      Q    ++LE+Q 
Sbjct: 3084 KADRRSLLSEIQAL-----HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138

Query: 124  ELKQLRNVLTNTQ----SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            EL  +++  T  Q    SE   +A +  EL +    +E         +KE +     +  
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
               E+   N +L  +    R+ Q   E  K ++ R EE  +     L+ ++  ++    Q
Sbjct: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258

Query: 240  LEEALETLK---TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
            L   LE  K    E +QK   ++ L       +      L V L+  K          D 
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318

Query: 297  EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK---LKQQLM 353
            E  ++       A+L   + T   +     PP PS   DLL EL     +K   + + L 
Sbjct: 3319 ERELH-------AQLQSSDGTGQSR-----PPLPS--EDLLKELQKQLEEKHSRIVELLN 3364

Query: 354  QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-KERQTALDN 412
            + E+ K   L T Q  +K  +  R +L  +QE     TE    +  LQ+  ++ Q  L+ 
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE---ANTEGQKKMHELQSKVEDLQRQLEE 3421

Query: 413  EKDRDSHEDGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKAL 456
            ++ +        Y++D+ G  +  +  ++     E  E RE  + L
Sbjct: 3422 KRQQ-------VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3460



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 119/531 (22%), Positives = 204/531 (38%), Gaps = 82/531 (15%)

Query: 23   RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
            + E K LS EL E  +E + +      + E K  +             I  EM    + F
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL-----------TISEEMFSKDKTF 1559

Query: 83   GQAHTNHKKVAADGESREESLIQESASKE---QYYVRKVLELQTELKQLRNV-LTNTQSE 138
                + H +++         L+      E   Q  VR+  E Q   + LR   +   + +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE------------ 186
             E    + +E+K +N+ +  QR  + D+      RE  LL++   L++            
Sbjct: 1620 REDQEQLQEEIKRLNRQLA-QRSSI-DNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677

Query: 187  -ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL--EDAIRLKEISERQLEEA 243
              N S Q Q     Q +VE +  K   K L+ + E +  ++   +   L++ + R L+  
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKE--KELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735

Query: 244  LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
            LE +KT    + ++ +   H + I D    S    SL             ++AEA V   
Sbjct: 1736 LEVVKTTAAVEETIGR---HVLGILDRSSKSQSSASLIW----------RSEAEASVKSC 1782

Query: 304  EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
             H    ++      S P   G   P   +  ++ S++   E  +L Q+L+     ++G  
Sbjct: 1783 VHEEHTRV---TDESIPSYSGSDMPRNDI--NMWSKVT-EEGTELSQRLV-----RSGFA 1831

Query: 364  ATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDG 422
             T  D + + E      S  Q  V +L E +S    +L+ +K  QT L  E  R   E  
Sbjct: 1832 GTEIDPENE-ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-- 1888

Query: 423  DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
                      E L C+         ELRE+L        ARE Q A E  + E       
Sbjct: 1889 --------ATESLKCQE--------ELRERL---HEESRARE-QLAVELSKAEGVIDGYA 1928

Query: 483  EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
            ++ +L E+  ++  +++ RLE+EL   S+   E +      Q+E    S +
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 104/490 (21%), Positives = 201/490 (41%), Gaps = 92/490 (18%)

Query: 5    SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-----HQLKL 59
            S+ EE    + E Q E    E+ R   +   T  +++Q  +    +LE++     + L+ 
Sbjct: 712  SKSEEMTLQINELQKE---IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQ----ESASKEQYYV 115
            +F +LE +   ++ E + L++   + HT          S+EE LI     +S SK+  + 
Sbjct: 769  KFAQLEAENSILKDEKKTLEDML-KIHTP--------VSQEERLIFLDSIKSKSKDSVWE 819

Query: 116  RKV---LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-----RLRDDI 167
            +++   +E   +LKQ    L     +     S A++  E+N   E+Q       +++DD+
Sbjct: 820  KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQEEYACLLKVKDDL 878

Query: 168  KEYKFREA-------RLLQDYSELEEENISLQKQVSVLRQNQVEF--------EGLKHEI 212
            ++ K ++        + L +   L+  N +  K  S +      F        E ++ + 
Sbjct: 879  EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938

Query: 213  KRLEEETEYLNSQ-LEDAIRLKEISERQ---------LEEALETLKTEREQKNSLRKEL- 261
              L E+ E    + LE + RL ++SE+          L E +++LK E+EQ +   +EL 
Sbjct: 939  TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998

Query: 262  ---SHYMSINDSFYTSHLHVSLDGL-----------------KFSDDA---AEPNNDAEA 298
               +H  + N     + +   LDG+                  F +++    E     E 
Sbjct: 999  IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058

Query: 299  LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
            +  G E     +L LD+  S  K+  L    PS    L  ELN+ + ++   +L QME +
Sbjct: 1059 MTVG-EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL-QMEAQ 1116

Query: 359  KAGLLATLQDTQKQL------EHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
            +  L         Q+      E  +   S ++E +    E +  L+++      Q  L  
Sbjct: 1117 RICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-----HQLELQT 1171

Query: 413  EKDRDSHEDG 422
             K +++ ++G
Sbjct: 1172 MKTQETGDEG 1181



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 155/785 (19%), Positives = 291/785 (37%), Gaps = 130/785 (16%)

Query: 57   LKLQFEEL-----EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE 111
            +KL+F E      E ++ +I S+M  L++       NHK   +  +  E++ ++E     
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDI----DVNHKSKLSSLQDLEKTKLEEQVQ-- 1341

Query: 112  QYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR---DDIK 168
                        EL+ L             ++S+ Q+LKE  QN E +   L+     + 
Sbjct: 1342 ------------ELESL-------------ISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376

Query: 169  EYKFREARLLQDYSELEEENISLQKQVSVLRQN---QVEFE---GLKHEIKRLEEETEYL 222
            E     +  +      E +        S +++N    +EF    G+K E   ++   +  
Sbjct: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY 1436

Query: 223  NSQLEDAIRLKEIS-ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
              QLE+ +    +S      +  E  +    ++N+   + +H +   +  Y + + +S D
Sbjct: 1437 QEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQD 1496

Query: 282  GLKFSD----DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
             + F      D               EHG   ++ L N  S P      P S   V  + 
Sbjct: 1497 QIGFQTFETVDVKFKEEFKPLSKELGEHG--KEILLSN--SDPHD---IPESKDCVLTIS 1549

Query: 338  SELNISEIQKLKQQLMQMEREKAGLLAT--LQDTQKQLEHTRGSLSEQQEKVTRLTENL- 394
             E+   +   + +Q +  E   + + A+  L   ++QLE  R  L  Q ++  + TE L 
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609

Query: 395  -SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQL 453
             + +R+++  +E Q  L  E  R + +      +D           ++       L E+L
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID---------NENLVSERERVLLEEL 1660

Query: 454  KALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVA 513
            +AL+    A   +   E      + Q   E    +E+ + +++EL  + E       ++ 
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE---DVPPEIL 1717

Query: 514  GETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRT 573
               + +L  A + L+    E+      V     ET  R +L             S   R+
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAV----EETIGRHVLGILDRSSKSQSSASLIWRS 1773

Query: 574  SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS-PGSSLPSPLSDPRREPMNIYNLIA 632
              EA          K  +  E  R    T +S PS  GS +P                  
Sbjct: 1774 EAEAS--------VKSCVHEEHTRV---TDESIPSYSGSDMP------------------ 1804

Query: 633  IIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
              R+ I       +  TELS++ + S   G  +D + E LM   L + S L    E++  
Sbjct: 1805 --RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELM---LNISSRLQAAVEKLLE 1859

Query: 693  LRTVLKANKQTAEVALANLKSKYENEKAMVTETMM-------KLRNELKALKEDAATFSS 745
              +   +  + A+V    L  +   +K   TE++        +L  E +A ++ A   S 
Sbjct: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSK 1919

Query: 746  LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
               +     D Y  +    +RQ+     ++KT   ++    Q+ L  + RL+ LE + +Q
Sbjct: 1920 AEGVI----DGYADEKTLFERQI-----QEKT--DIIDRLEQELLCASNRLQELEAEQQQ 1968

Query: 806  TRRGR 810
             +  R
Sbjct: 1969 IQEER 1973



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 168/815 (20%), Positives = 303/815 (37%), Gaps = 117/815 (14%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
            E L+ E+KRL+ +LA+  R  I        ++ E+ ++ L  EELE   +   +  E+L 
Sbjct: 1624 EQLQEEIKRLNRQLAQ--RSSIDNEN----LVSERERVLL--EELEALKQLSLAGREKLC 1675

Query: 80   EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
                     +        +  +  ++E   KE+   RK  ++  E+  L N     Q  N
Sbjct: 1676 -----CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYALQKAN 1728

Query: 140  ERLASVAQELKEINQNVEIQRGR----LRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
             RL  +  E+ +    VE   GR    + D   + +   + + +  +E   ++   ++  
Sbjct: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788

Query: 196  SVLRQNQVEFEGL---KHEI----KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
             V  ++   + G    +++I    K  EE TE     +       EI     E  L    
Sbjct: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848

Query: 249  TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGL 308
              +     L + +S   S  +    +   +  +  +   +A E     E L         
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908

Query: 309  AKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKLKQQLMQMEREKAGLLA 364
            A+  L  + S  K EG+           L E  I E    I +L+Q+L+         L 
Sbjct: 1909 AREQLAVELS--KAEGVIDGYAD--EKTLFERQIQEKTDIIDRLEQELLCASNR----LQ 1960

Query: 365  TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
             L+  Q+Q++  R  LS Q+E          A++      E+Q   + EK        + 
Sbjct: 1961 ELEAEQQQIQEERELLSRQKE----------AMKAEAGPVEQQLLQETEKLMK-----EK 2005

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY-EAEGQALTE 483
             EV     ++             +L++Q+KAL       E    E+  R+ E E +  TE
Sbjct: 2006 LEVQCQAEKV-----------RDDLQKQVKAL-------EIDVEEQVSRFIELEQEKNTE 2047

Query: 484  KVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCM 543
             + L     +Q++ L  +LEK  K + + A + +    V Q E+    ++L  +     +
Sbjct: 2048 LMDL----RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI 2103

Query: 544  CNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTG 603
              ++T         RE +  A           E   + S +LL K  L  +    +    
Sbjct: 2104 SEHQT---------REVEQLANHLK-------EKTDKCSELLLSKEQLQRDIQERN---- 2143

Query: 604  DSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGP 663
                     L   + +  +  +   +    + D+ KH   AV+   ELS +     E   
Sbjct: 2144 ----EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHF-GAVEAKPELSLEVQLQAERDA 2197

Query: 664  AVDKDKEA--LMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM 721
               K+KE   L E++ + +  L  K E++  L   L+  K+ +   L  L    E E  +
Sbjct: 2198 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL----EQENKL 2253

Query: 722  VTETMMKLRNELKALKEDAATFSS----LRAMFATRCDEYITQLDEMQRQLAAAEDEKK- 776
              + M KL     A+KE  A  +     L   FA    E   ++D++  Q+   + + K 
Sbjct: 2254 FKDDMEKLG---LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2310

Query: 777  -TLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
             T N ++    +    L  ++E L  D E  +R R
Sbjct: 2311 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2345



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 63/270 (23%), Positives = 108/270 (40%), Gaps = 57/270 (21%)

Query: 5    SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
            ++E  YA+L+       +       +HEL E  R+K+Q     L VL +K   +LQFE  
Sbjct: 3490 TKESNYAKLIE------MNGGGTGCNHEL-EMIRQKLQCVASKLQVLPQKASERLQFETA 3542

Query: 65   EVD-----YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQES---ASKEQYYVR 116
            + +      E I   + QL++  GQ            +  E SL+  S    S  +  +R
Sbjct: 3543 DDEDFIWVQENIDEIILQLQKLTGQ------------QGEEPSLVSPSTSCGSLTERLLR 3590

Query: 117  KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR--- 173
            +  EL   + QL      T+ +N+ L ++  +L+E  +    Q G  RD+   +      
Sbjct: 3591 QNAELTGHISQL------TEEKND-LRNMVMKLEEQIRWYR-QTGAGRDNSSRFSLNGGA 3642

Query: 174  --EARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
              EA +  +      E ++LQK                  +KR E E   L ++L +   
Sbjct: 3643 NIEAIIASEKEVWNREKLTLQK-----------------SLKRAEAEVYKLKAELRNDSL 3685

Query: 232  LKEISERQLEEALETLKTEREQKNSLRKEL 261
            L+ +S       L+ +  +  +  S RK L
Sbjct: 3686 LQTLSPDSEHVTLKRIYGKYLRAESFRKAL 3715



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 73/411 (17%), Positives = 177/411 (43%), Gaps = 48/411 (11%)

Query: 125  LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
            +  L++++T  Q + E   +   +  + +++    RG L   +++    E  +L      
Sbjct: 2991 ISSLKDLITKMQLQRE---AEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3047

Query: 185  EEENISLQKQVSVLR--QNQVEFEGLKHEI----------KRLEEETEYLNSQLED---A 229
            E   +     V +L   + +++ +G++++           + L  E + L++Q+      
Sbjct: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107

Query: 230  IRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL---KF 285
            ++ ++ SE+  +E LE  ++ ++ Q   ++ ELS   S+ D        +S + +   + 
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMVVAEL 3164

Query: 286  SDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI 345
              + A+   + E  +   +H  L +L         K + +          LL++   SE 
Sbjct: 3165 KSELAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV---------HLLNDTLASEQ 3214

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K ++    +E+EKA L  + +  +++LE  + SL  Q+++  +L  NL   ++ Q   E
Sbjct: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL--NLLLEQQKQLLNE 3272

Query: 406  RQTALDNEK----DRDSHEDGDYYEVDI--NGPEILACKYHVAVAEAGELREQLKALRST 459
             Q  +++++     + S E G   E+ +     ++   +    +    EL  QL++   T
Sbjct: 3273 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3332

Query: 460  HEAREAQHAEE-----KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
             ++R    +E+     + + E +   + E ++  EK      +   ++EK+
Sbjct: 3333 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 45/215 (20%), Positives = 92/215 (42%), Gaps = 46/215 (21%)

Query: 51   LEEKH----QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQE 106
            LEEKH    +L  + E+ ++D    R +ME+ ++   +     ++   +G+ +   L   
Sbjct: 3352 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS- 3410

Query: 107  SASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD 166
                      KV +LQ +L++ R  +     E +RL  + QE     Q  E++R   R+ 
Sbjct: 3411 ----------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF----QKQELEREEKRES 3456

Query: 167  IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE-----------------GLK 209
                      L Q+ +E    +++  +  + + Q ++E E                 G  
Sbjct: 3457 -------RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCN 3509

Query: 210  HEIKRLEEETEYLNSQLEDAIRLKEISER-QLEEA 243
            HE++ + ++ + + S+L+  +  ++ SER Q E A
Sbjct: 3510 HELEMIRQKLQCVASKLQ--VLPQKASERLQFETA 3542


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 109/546 (19%), Positives = 223/546 (40%), Gaps = 68/546 (12%)

Query: 2   SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
           S   E +E   ++ E   + +  E K L  +   TT +K+   E    ++++  ++K   
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL-LGELQEQIVQKNQEIKNMK 377

Query: 62  EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
            EL    +  R   E++K+  G      K+   D +  E  ++Q    + Q   RK+ +L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF-ETDIVQRMEQETQ---RKLEQL 433

Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
           + EL ++       Q    +   + Q + ++ +     +G + + ++ Y    + +  + 
Sbjct: 434 RAELDEMYG----QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY----SNITVNE 485

Query: 182 SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
            +++  N+++ +    L+    + E LK E+  + EE   L  QLED +     S  Q++
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545

Query: 242 EALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVN 301
            A +T+  +  + N   K LS    +     ++           S+   E     EA V 
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA-----------SESRKELELKHEAEVT 594

Query: 302 GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
            ++     KL +  K      + +A    + +  L ++L  S  ++L +    +E E   
Sbjct: 595 NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI 650

Query: 362 LLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDR 416
            +  L+D      ++Q++  +  +S++ E +    +NL        +K+ Q  L+  K +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-------ITKQNQLILEISKLK 703

Query: 417 DSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
           D  +             ++  K      +  EL+++++ LR        Q  +EKG  E 
Sbjct: 704 DLQQS------------LVNSKSEEMTLQINELQKEIEILR--------QEEKEKGTLEQ 743

Query: 477 EGQALTEKVSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSLS----VAQDELV 528
           E Q L  K  LLEK  ++     +E  A+LE E   + D     +  L     V+Q+E +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERL 803

Query: 529 TFSEEL 534
            F + +
Sbjct: 804 IFLDSI 809



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 148/766 (19%), Positives = 320/766 (41%), Gaps = 82/766 (10%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
            V E Q + +   +  L+ +L +T  +K +  E    +LEEK  L+ Q E+L  +    R 
Sbjct: 483  VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542

Query: 74   EMEQLKEAFGQAHTN----HK----------KVAADGESREESLIQESASKEQYYVRKVL 119
            ++++ ++   +  +     HK          ++ +  ESR+E  ++  A    Y ++  +
Sbjct: 543  QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602

Query: 120  ELQTELKQLRNVLTNTQSENERLA-----SVAQELKEINQNVEIQR----GRLRDDIKEY 170
              + +   L  +  + ++E ERL      S  +EL ++ +++EI+      +L+D++  +
Sbjct: 603  LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662

Query: 171  KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE-ETEYLNSQLEDA 229
              ++   LQ+    + E +  +K   + +QNQ     L  EI +L++ +   +NS+ E+ 
Sbjct: 663  YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ-----LILEISKLKDLQQSLVNSKSEE- 716

Query: 230  IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSD 287
                 +   +L++ +E L+ E ++K +L +E+   + +        +    + L  KF+ 
Sbjct: 717  ---MTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772

Query: 288  DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK 347
              AE N+  +      E       P+  +      + +   S   V +   E+ I E + 
Sbjct: 773  LEAE-NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831

Query: 348  LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQ 407
            LKQQ +Q+  E      T    +K  E     L E+   + ++ ++      L+ SK +Q
Sbjct: 832  LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD------LEDSKNKQ 885

Query: 408  TALDNEKDRDSHEDGDYYEVDINGPEILACKY---HVAVAEAGELREQLKALRSTHEARE 464
                  K +  +E+     ++    ++ +  +      VAE  E+ E ++  + T E  E
Sbjct: 886  ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--KDTTELME 943

Query: 465  AQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
                 ++ + E     L++++S L +  +Q    ++ L +E+K +     + Q SL   +
Sbjct: 944  KLEVTKREKLE-----LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ--EKEQVSLRCRE 996

Query: 525  DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
             E++       N    V  C+ +  + +        +G  G  S   ++     G  S I
Sbjct: 997  LEIIINHNRAEN----VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEESKI 1048

Query: 585  LLP-----KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK 639
            ++      + +   E  + +    D  PS         + P  E   +   + +++ +  
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP-SENDKLQKELNVLKSEQN 1107

Query: 640  HLQAAVDRTTELSRQRIA-SQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLK 698
             L+       ++  QRI  S      VD+ +E +  E  K K+L S K E I      +K
Sbjct: 1108 DLR------LQMEAQRICLSLVYSTHVDQVREYMENE--KDKALCSLKEELIFAQEEKIK 1159

Query: 699  ANKQTAEVALANLKSKYENEKAMVTETMM-KLRNELKALKEDAATF 743
              ++  ++ L  +K++   ++      ++ KL+   KA+ E+ + F
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ---KAVSEECSYF 1202



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 151/811 (18%), Positives = 341/811 (42%), Gaps = 98/811 (12%)

Query: 26  VKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR-----SEMEQLKE 80
           + +L+  L +  REK +     L + E+  +L++QF++L+   E +R     S    L +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQ 265

Query: 81  AFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT-----ELKQLRNVLTNT 135
           A  Q  T+ +++       ++ L+++   K++ +  ++  LQ      E++Q + V  + 
Sbjct: 266 AKQQILTHQQQL-----EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320

Query: 136 QSENERLASVAQEL-----KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
           + E +   ++ +EL     +E  + +E+ + +L    K     + +++Q   E++   + 
Sbjct: 321 KEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLE 379

Query: 191 LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAI--RLKEISERQLEEALETL- 247
           L       RQ+  E + L   ++ L++   + +SQ E  I  R+++ ++R+LE+    L 
Sbjct: 380 LTNSKQKERQSSEEIKQLMGTVEELQKR-NHKDSQFETDIVQRMEQETQRKLEQLRAELD 438

Query: 248 KTEREQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
           +   +Q   +++EL   +M+  +   T H     + L+ S      N D   L+N     
Sbjct: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-SYSNITVNEDQIKLMN----V 493

Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
            + +L +  + +  +KE L                  E+  + ++   ++R+   L+  L
Sbjct: 494 AINELNIKLQDTNSQKEKLK----------------EELGLILEEKCALQRQLEDLVEEL 537

Query: 367 QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY-- 424
             +++Q++  R +++EQ+ K+    ++LS +  L+A  E  +A ++ K+ +   + +   
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTN 595

Query: 425 --YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
              ++++   E  A    +A ++  EL      L  +HE   ++  E+    E E +   
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED---LEIEHRINI 652

Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
           EK  L +      ++ +  L+ E+ +  +     + +L   Q++L+    +L +L   + 
Sbjct: 653 EK--LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710

Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
              +E     + +  +E +         G    E +     + L   LL  +    +   
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----ELQLKTELLEKQMKEKE--- 763

Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQR------- 655
                          +D + +   +    +I++D+ K L+  +   T +S++        
Sbjct: 764 ---------------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808

Query: 656 IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKY 715
           I S+      +K+ E L+EE   LK       E+I   R      ++  EV    L+ +Y
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868

Query: 716 -------ENEKAMVTETMMKLRNELKALKED---AATFSSLRAMFATRCDEYITQLDEMQ 765
                  ++ +    +  ++ +++LKAL E+        +   M ++  DE  T + E  
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928

Query: 766 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRL 796
                 E +   L   L +  ++KL L+QRL
Sbjct: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRL 959



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 174/882 (19%), Positives = 337/882 (38%), Gaps = 156/882 (17%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK--HQLK 58
            + A  ++ +  R ++  Q E ++AE   +  +L + T EK+   +  +    EK    L+
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKEKLEVQCQAEKVRDDLQ 2020

Query: 59   LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESASKEQ 112
             Q + LE+D E   S   +L++   + +T    +    ++ E+ L      + E A   +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE 2077

Query: 113  Y----YVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIK 168
            +    + +++ +L+ +LK +      ++ +   +  +A  LKE             D   
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT-----------DKCS 2126

Query: 169  EYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY-LNSQLE 227
            E    + +L +D  E  EE   L+ +V  L Q  +  E  KH    +E + E  L  QL+
Sbjct: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL-VEDRKH-FGAVEAKPELSLEVQLQ 2184

Query: 228  ---DAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL-HVSLDGL 283
               DAI  KE     LEE LE  + E E KN   ++L   + I     T+ L  +  +  
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2244

Query: 284  KFSDDAAEPN---NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL 340
             F DD  +      +++A+    +H    K          +KE         V+ L  +L
Sbjct: 2245 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKF----AQIIQEKEVEIDQLNEQVTKLQQQL 2300

Query: 341  NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRL 400
             I+   K+ ++  ++ R+    +  L   Q+ ++  R      +E++ +L E +  L++ 
Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR------EEEIEQLNEVIEKLQQE 2354

Query: 401  QASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH 460
             A+  ++T+++                            H    EA  L+ QL  + +  
Sbjct: 2355 LANIGQKTSMN---------------------------AHSLSEEADSLKHQLDVVIAEK 2387

Query: 461  EAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDREL---LARLEKELKKVSDVAGETQ 517
             A E Q        E   + +T   ++L++ + +  +L   L  L++E + V  +    +
Sbjct: 2388 LALEQQ-------VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE 2440

Query: 518  GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEA 577
             S++VA D L     EL      V +  +   +     Y++               S E 
Sbjct: 2441 NSVNVAIDHLSKDKPEL-----EVVLTEDALKSLENQTYFK---------------SFEE 2480

Query: 578  RGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE--------PMNIYN 629
             G+ S I L   LL  E+      T  +     +     + D + +           I N
Sbjct: 2481 NGKGSIINLETRLLQLES------TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2534

Query: 630  LIAIIRDQIKHL---QAAVDRTTELSR-----QRIASQELGPAVDK----DKEALMEEIL 677
            L  I+ +++      Q  ++   E ++     Q I+S+     +       ++ L  +I 
Sbjct: 2535 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS 2594

Query: 678  KLKSLLSTKREQITTLRTVLKANKQTAEVALANL------------------KSKYENEK 719
             L   +S    Q+  + T L   K+  E+A  N+                  K + E EK
Sbjct: 2595 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2654

Query: 720  AMVTE--TMMKLRNELKALKEDAATFSSLRAM----FATRCD--EYITQLDEMQRQLAAA 771
                +   ++K   EL    E++  F+ L A+     AT+ +   Y  + +++Q +L   
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK 2714

Query: 772  EDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
            E    +L   L           ++L +LE + E   +   KA
Sbjct: 2715 ETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2756



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 118/551 (21%), Positives = 233/551 (42%), Gaps = 79/551 (14%)

Query: 9    EYARLVMEAQPE--WLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
            ++A+++ E + E   L  +V +L  +L  TT  K         V+EEK++L     +LE 
Sbjct: 2274 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK---------VIEEKNEL---IRDLET 2321

Query: 67   DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
              E + S+ E +K        N ++         E L QE A+  Q        L  E  
Sbjct: 2322 QIECLMSDQECVKR-------NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374

Query: 127  QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
             L++ L    +E     ++ Q+++  N+ +      +++ +KE  F+  +L Q+   L+ 
Sbjct: 2375 SLKHQLDVVIAEK---LALEQQVETANEEMTF----MKNVLKETNFKMNQLTQELFSLKR 2427

Query: 187  ENISLQKQVSV-----------LRQNQVEFEGLKHE--IKRLEEETEYLNSQLEDAIRLK 233
            E  S++K  S+           L +++ E E +  E  +K LE +T + + +      + 
Sbjct: 2428 ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII 2487

Query: 234  EISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
             +  R  QLE  +     E  Q     K++         F T  L   +  L+       
Sbjct: 2488 NLETRLLQLESTVSAKDLELTQCYKQIKDMQE----QGQFETEMLQKKIVNLQ----KIV 2539

Query: 292  PNNDAEALVNGFEHGGL---AKLPLDNKT--STPKKEGLAPPSPSLVSDLLSELNISEIQ 346
                A ALV+  +   +   AK   DN+T  S P++  +       ++ L  +   S+I 
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-----LNQLREDELGSDIS 2594

Query: 347  KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER 406
             L  ++ ++E +   +  +L   ++Q+E    ++ E+++K+  L + L    + Q  KE+
Sbjct: 2595 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2654

Query: 407  QTA--------LDNEKDRDSHEDGDYYEVDINGPEILACKYHVA--VAEAGELREQLKAL 456
            + +           E    + E G + E++    E +A K  +A    +A +L+E+L  +
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL-LV 2713

Query: 457  RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASR---QDRELLARLEK-ELKKVSDV 512
            + T+     +   +   + AE +   EK+S+LEK      Q+ +     E   +K    +
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2770

Query: 513  AGETQGSLSVA 523
            A +T G+L ++
Sbjct: 2771 ASQTDGTLKIS 2781



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 158/761 (20%), Positives = 308/761 (40%), Gaps = 128/761 (16%)

Query: 79  KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
           +E FG   +  ++ A D  +  E +  E A K+     ++ EL  EL+++R V   T+  
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQH----EIEELNRELEEMR-VTYGTEG- 189

Query: 139 NERLASVAQELKEINQNVEIQRG---RLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
                   Q+L+E    ++ + G   +L  ++++ +  +   ++++ EL E++  LQ Q 
Sbjct: 190 -------LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242

Query: 196 SVLRQNQV-----------EFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ---LE 241
             L+ ++            +    K +I   +++ E  +  LED  + KE    Q   L+
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302

Query: 242 EALETLKTEREQK--NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--- 296
           E ++  + E+++K  NS ++E+    +I +   T  +      L+  D     +      
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 297 -EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
            E +V   +     KL L N     ++      S   +  L+    + E+QK   +  Q 
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQ------SSEEIKQLMG--TVEELQKRNHKDSQF 414

Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQ-EKVTRLTENLSALRRLQASKERQTALDNEK 414
           E +    +   Q+TQ++LE  R  L E   +++ ++ + L  +R+  A  E        K
Sbjct: 415 ETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKT--RHK 468

Query: 415 DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY 474
               +    Y  + +N  +I     +VA+ E     +   + +   +       EEK   
Sbjct: 469 GEMENALRSYSNITVNEDQIKLM--NVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526

Query: 475 EAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQD---ELVTFS 531
           + + + L E++S   +  ++ R+ +A  E +L        E   SLS  +D   E+V+ S
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLN-------EAHKSLSTVEDLKAEIVSAS 579

Query: 532 EELANL-YHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
           E    L   H     N      ML+  +E      R +       E    R+ +L     
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMAESQEA--ELERLRTQLLF---- 631

Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTT 649
                         S     S L   L    R  +NI  L    +D +  H +  +D   
Sbjct: 632 --------------SHEEELSKLKEDLEIEHR--INIEKL----KDNLGIHYKQQIDGLQ 671

Query: 650 ELSRQRIASQELGPAVDKD-----KEALMEEILKLK----SLLSTKREQITTLRTVLKAN 700
               Q+I + +     +KD     +  L+ EI KLK    SL+++K E++T     L+ N
Sbjct: 672 NEMSQKIETMQF----EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT-----LQIN 722

Query: 701 KQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMFATRCDEYIT 759
           +   E+ +   + K   EK  + + + +L+ + + L K+     + L+  FA        
Sbjct: 723 ELQKEIEILRQEEK---EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA-------- 771

Query: 760 QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
              +++ + +  +DEKKTL  +L+  I   ++  +RL  L+
Sbjct: 772 ---QLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLD 807



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 91/406 (22%), Positives = 158/406 (38%), Gaps = 43/406 (10%)

Query: 65   EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRKVLELQT 123
            + D  ++ SE++ L      A  N +K+    E   E   QE      Q    ++LE+Q 
Sbjct: 3076 KADRRSLLSEIQAL-----HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130

Query: 124  ELKQLRNVLTNTQ----SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
            EL  +++  T  Q    SE   +A +  EL +    +E         +KE +     +  
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3190

Query: 180  DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
               E+   N +L  +    R+ Q   E  K ++ R EE  +     L+ ++  ++    Q
Sbjct: 3191 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3250

Query: 240  LEEALETLK---TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
            L   LE  K    E +QK   ++ L       +      L V L+  K          D 
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3310

Query: 297  EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK---LKQQLM 353
            E  ++       A+L   + T   +     PP PS   DLL EL     +K   + + L 
Sbjct: 3311 ERELH-------AQLQSSDGTGQSR-----PPLPS--EDLLKELQKQLEEKHSRIVELLN 3356

Query: 354  QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-KERQTALDN 412
            + E+ K   L T Q  +K  +  R +L  +QE     TE    +  LQ+  ++ Q  L+ 
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE---ANTEGQKKMHELQSKVEDLQRQLEE 3413

Query: 413  EKDRDSHEDGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKAL 456
            ++ +        Y++D+ G  +  +  ++     E  E RE  + L
Sbjct: 3414 KRQQ-------VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3452



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 119/531 (22%), Positives = 204/531 (38%), Gaps = 82/531 (15%)

Query: 23   RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
            + E K LS EL E  +E + +      + E K  +             I  EM    + F
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL-----------TISEEMFSKDKTF 1559

Query: 83   GQAHTNHKKVAADGESREESLIQESASKE---QYYVRKVLELQTELKQLRNV-LTNTQSE 138
                + H +++         L+      E   Q  VR+  E Q   + LR   +   + +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE------------ 186
             E    + +E+K +N+ +  QR  + D+      RE  LL++   L++            
Sbjct: 1620 REDQEQLQEEIKRLNRQLA-QRSSI-DNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677

Query: 187  -ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL--EDAIRLKEISERQLEEA 243
              N S Q Q     Q +VE +  K   K L+ + E +  ++   +   L++ + R L+  
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKE--KELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735

Query: 244  LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
            LE +KT    + ++ +   H + I D    S    SL             ++AEA V   
Sbjct: 1736 LEVVKTTAAVEETIGR---HVLGILDRSSKSQSSASLIW----------RSEAEASVKSC 1782

Query: 304  EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
             H    ++      S P   G   P   +  ++ S++   E  +L Q+L+     ++G  
Sbjct: 1783 VHEEHTRV---TDESIPSYSGSDMPRNDI--NMWSKVT-EEGTELSQRLV-----RSGFA 1831

Query: 364  ATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDG 422
             T  D + + E      S  Q  V +L E +S    +L+ +K  QT L  E  R   E  
Sbjct: 1832 GTEIDPENE-ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-- 1888

Query: 423  DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
                      E L C+         ELRE+L        ARE Q A E  + E       
Sbjct: 1889 --------ATESLKCQE--------ELRERL---HEESRARE-QLAVELSKAEGVIDGYA 1928

Query: 483  EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
            ++ +L E+  ++  +++ RLE+EL   S+   E +      Q+E    S +
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 104/490 (21%), Positives = 201/490 (41%), Gaps = 92/490 (18%)

Query: 5    SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-----HQLKL 59
            S+ EE    + E Q E    E+ R   +   T  +++Q  +    +LE++     + L+ 
Sbjct: 712  SKSEEMTLQINELQKE---IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQ----ESASKEQYYV 115
            +F +LE +   ++ E + L++   + HT          S+EE LI     +S SK+  + 
Sbjct: 769  KFAQLEAENSILKDEKKTLEDML-KIHTP--------VSQEERLIFLDSIKSKSKDSVWE 819

Query: 116  RKV---LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-----RLRDDI 167
            +++   +E   +LKQ    L     +     S A++  E+N   E+Q       +++DD+
Sbjct: 820  KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQEEYACLLKVKDDL 878

Query: 168  KEYKFREA-------RLLQDYSELEEENISLQKQVSVLRQNQVEF--------EGLKHEI 212
            ++ K ++        + L +   L+  N +  K  S +      F        E ++ + 
Sbjct: 879  EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938

Query: 213  KRLEEETEYLNSQ-LEDAIRLKEISERQ---------LEEALETLKTEREQKNSLRKEL- 261
              L E+ E    + LE + RL ++SE+          L E +++LK E+EQ +   +EL 
Sbjct: 939  TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998

Query: 262  ---SHYMSINDSFYTSHLHVSLDGL-----------------KFSDDA---AEPNNDAEA 298
               +H  + N     + +   LDG+                  F +++    E     E 
Sbjct: 999  IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058

Query: 299  LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
            +  G E     +L LD+  S  K+  L    PS    L  ELN+ + ++   +L QME +
Sbjct: 1059 MTVG-EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL-QMEAQ 1116

Query: 359  KAGLLATLQDTQKQL------EHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
            +  L         Q+      E  +   S ++E +    E +  L+++      Q  L  
Sbjct: 1117 RICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-----HQLELQT 1171

Query: 413  EKDRDSHEDG 422
             K +++ ++G
Sbjct: 1172 MKTQETGDEG 1181



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 155/785 (19%), Positives = 291/785 (37%), Gaps = 130/785 (16%)

Query: 57   LKLQFEEL-----EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE 111
            +KL+F E      E ++ +I S+M  L++       NHK   +  +  E++ ++E     
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDI----DVNHKSKLSSLQDLEKTKLEEQVQ-- 1341

Query: 112  QYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR---DDIK 168
                        EL+ L             ++S+ Q+LKE  QN E +   L+     + 
Sbjct: 1342 ------------ELESL-------------ISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376

Query: 169  EYKFREARLLQDYSELEEENISLQKQVSVLRQN---QVEFE---GLKHEIKRLEEETEYL 222
            E     +  +      E +        S +++N    +EF    G+K E   ++   +  
Sbjct: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY 1436

Query: 223  NSQLEDAIRLKEIS-ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
              QLE+ +    +S      +  E  +    ++N+   + +H +   +  Y + + +S D
Sbjct: 1437 QEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQD 1496

Query: 282  GLKFSD----DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
             + F      D               EHG   ++ L N  S P      P S   V  + 
Sbjct: 1497 QIGFQTFETVDVKFKEEFKPLSKELGEHG--KEILLSN--SDPHD---IPESKDCVLTIS 1549

Query: 338  SELNISEIQKLKQQLMQMEREKAGLLAT--LQDTQKQLEHTRGSLSEQQEKVTRLTENL- 394
             E+   +   + +Q +  E   + + A+  L   ++QLE  R  L  Q ++  + TE L 
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609

Query: 395  -SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQL 453
             + +R+++  +E Q  L  E  R + +      +D           ++       L E+L
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID---------NENLVSERERVLLEEL 1660

Query: 454  KALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVA 513
            +AL+    A   +   E      + Q   E    +E+ + +++EL  + E       ++ 
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE---DVPPEIL 1717

Query: 514  GETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRT 573
               + +L  A + L+    E+      V     ET  R +L             S   R+
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAV----EETIGRHVLGILDRSSKSQSSASLIWRS 1773

Query: 574  SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS-PGSSLPSPLSDPRREPMNIYNLIA 632
              EA          K  +  E  R    T +S PS  GS +P                  
Sbjct: 1774 EAEAS--------VKSCVHEEHTRV---TDESIPSYSGSDMP------------------ 1804

Query: 633  IIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
              R+ I       +  TELS++ + S   G  +D + E LM   L + S L    E++  
Sbjct: 1805 --RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELM---LNISSRLQAAVEKLLE 1859

Query: 693  LRTVLKANKQTAEVALANLKSKYENEKAMVTETMM-------KLRNELKALKEDAATFSS 745
              +   +  + A+V    L  +   +K   TE++        +L  E +A ++ A   S 
Sbjct: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSK 1919

Query: 746  LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
               +     D Y  +    +RQ+     ++KT   ++    Q+ L  + RL+ LE + +Q
Sbjct: 1920 AEGVI----DGYADEKTLFERQI-----QEKT--DIIDRLEQELLCASNRLQELEAEQQQ 1968

Query: 806  TRRGR 810
             +  R
Sbjct: 1969 IQEER 1973



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 168/816 (20%), Positives = 302/816 (37%), Gaps = 127/816 (15%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
            E L+ E+KRL+ +LA+  R  I        ++ E+ ++ L  EELE   +   +  E+L 
Sbjct: 1624 EQLQEEIKRLNRQLAQ--RSSIDNEN----LVSERERVLL--EELEALKQLSLAGREKLC 1675

Query: 80   EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
                     +        +  +  ++E   KE+   RK  ++  E+  L N     Q  N
Sbjct: 1676 -----CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYALQKAN 1728

Query: 140  ERLASVAQELKEINQNVEIQRGR----LRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
             RL  +  E+ +    VE   GR    + D   + +   + + +  +E   ++   ++  
Sbjct: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788

Query: 196  SVLRQNQVEFEGL---KHEI----KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
             V  ++   + G    +++I    K  EE TE     +       EI     E  L    
Sbjct: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848

Query: 249  TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGL 308
              +     L + +S   S  +    +   +  +  +   +A E     E L         
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908

Query: 309  AKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKLKQQLMQMEREKAGLLA 364
            A+  L  + S  K EG+           L E  I E    I +L+Q+L+         L 
Sbjct: 1909 AREQLAVELS--KAEGVIDGYAD--EKTLFERQIQEKTDIIDRLEQELLCASNR----LQ 1960

Query: 365  TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
             L+  Q+Q++  R  LS Q+E          A++      E+Q   + EK        + 
Sbjct: 1961 ELEAEQQQIQEERELLSRQKE----------AMKAEAGPVEQQLLQETEKLMK-----EK 2005

Query: 425  YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY-EAEGQALTE 483
             EV     ++             +L++Q+KAL       E    E+  R+ E E +  TE
Sbjct: 2006 LEVQCQAEKV-----------RDDLQKQVKAL-------EIDVEEQVSRFIELEQEKNTE 2047

Query: 484  KVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCM 543
             + L     +Q++ L  +LEK  K + + A + +    V Q E+    ++L  +     +
Sbjct: 2048 LMDL----RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI 2103

Query: 544  CNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTG 603
              ++T         RE +  A           E   + S +LL K  L  +    +    
Sbjct: 2104 SEHQT---------REVEQLANHLK-------EKTDKCSELLLSKEQLQRDIQERN---- 2143

Query: 604  DSSPSPGSSLPSPLSDPRREPMNIYNL-IAIIRDQIKHLQAAVDRTTELSRQRIASQELG 662
                           +  +    +  L  A++ +  KH   AV+   ELS +     E  
Sbjct: 2144 --------------EEIEKLEFRVRELEQALLVEDRKHF-GAVEAKPELSLEVQLQAERD 2188

Query: 663  PAVDKDKEA--LMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
                K+KE   L E++ + +  L  K E++  L   L+  K+ +   L  L    E E  
Sbjct: 2189 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL----EQENK 2244

Query: 721  MVTETMMKLRNELKALKEDAATFSS----LRAMFATRCDEYITQLDEMQRQLAAAEDEKK 776
            +  + M KL     A+KE  A  +     L   FA    E   ++D++  Q+   + + K
Sbjct: 2245 LFKDDMEKLG---LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301

Query: 777  --TLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
              T N ++    +    L  ++E L  D E  +R R
Sbjct: 2302 ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 63/270 (23%), Positives = 108/270 (40%), Gaps = 57/270 (21%)

Query: 5    SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
            ++E  YA+L+       +       +HEL E  R+K+Q     L VL +K   +LQFE  
Sbjct: 3482 TKESNYAKLIE------MNGGGTGCNHEL-EMIRQKLQCVASKLQVLPQKASERLQFETA 3534

Query: 65   EVD-----YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQES---ASKEQYYVR 116
            + +      E I   + QL++  GQ            +  E SL+  S    S  +  +R
Sbjct: 3535 DDEDFIWVQENIDEIILQLQKLTGQ------------QGEEPSLVSPSTSCGSLTERLLR 3582

Query: 117  KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR--- 173
            +  EL   + QL      T+ +N+ L ++  +L+E  +    Q G  RD+   +      
Sbjct: 3583 QNAELTGHISQL------TEEKND-LRNMVMKLEEQIRWYR-QTGAGRDNSSRFSLNGGA 3634

Query: 174  --EARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
              EA +  +      E ++LQK                  +KR E E   L ++L +   
Sbjct: 3635 NIEAIIASEKEVWNREKLTLQK-----------------SLKRAEAEVYKLKAELRNDSL 3677

Query: 232  LKEISERQLEEALETLKTEREQKNSLRKEL 261
            L+ +S       L+ +  +  +  S RK L
Sbjct: 3678 LQTLSPDSEHVTLKRIYGKYLRAESFRKAL 3707



 Score = 35.4 bits (80), Expect = 0.22
 Identities = 73/411 (17%), Positives = 177/411 (43%), Gaps = 48/411 (11%)

Query: 125  LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
            +  L++++T  Q + E   +   +  + +++    RG L   +++    E  +L      
Sbjct: 2983 ISSLKDLITKMQLQRE---AEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039

Query: 185  EEENISLQKQVSVLR--QNQVEFEGLKHEI----------KRLEEETEYLNSQLED---A 229
            E   +     V +L   + +++ +G++++           + L  E + L++Q+      
Sbjct: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3099

Query: 230  IRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL---KF 285
            ++ ++ SE+  +E LE  ++ ++ Q   ++ ELS   S+ D        +S + +   + 
Sbjct: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMVVAEL 3156

Query: 286  SDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI 345
              + A+   + E  +   +H  L +L         K + +          LL++   SE 
Sbjct: 3157 KSELAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV---------HLLNDTLASEQ 3206

Query: 346  QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
            +K ++    +E+EKA L  + +  +++LE  + SL  Q+++  +L  NL   ++ Q   E
Sbjct: 3207 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL--NLLLEQQKQLLNE 3264

Query: 406  RQTALDNEK----DRDSHEDGDYYEVDI--NGPEILACKYHVAVAEAGELREQLKALRST 459
             Q  +++++     + S E G   E+ +     ++   +    +    EL  QL++   T
Sbjct: 3265 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3324

Query: 460  HEAREAQHAEE-----KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
             ++R    +E+     + + E +   + E ++  EK      +   ++EK+
Sbjct: 3325 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 45/215 (20%), Positives = 92/215 (42%), Gaps = 46/215 (21%)

Query: 51   LEEKH----QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQE 106
            LEEKH    +L  + E+ ++D    R +ME+ ++   +     ++   +G+ +   L   
Sbjct: 3344 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS- 3402

Query: 107  SASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD 166
                      KV +LQ +L++ R  +     E +RL  + QE     Q  E++R   R+ 
Sbjct: 3403 ----------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF----QKQELEREEKRES 3448

Query: 167  IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE-----------------GLK 209
                      L Q+ +E    +++  +  + + Q ++E E                 G  
Sbjct: 3449 -------RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCN 3501

Query: 210  HEIKRLEEETEYLNSQLEDAIRLKEISER-QLEEA 243
            HE++ + ++ + + S+L+  +  ++ SER Q E A
Sbjct: 3502 HELEMIRQKLQCVASKLQ--VLPQKASERLQFETA 3534


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 175/822 (21%), Positives = 327/822 (39%), Gaps = 102/822 (12%)

Query: 22   LRAEVKRLSHELAETTREKIQAAE-YGLAVLEEKHQLKLQFEE---LEVDYEAIRSEMEQ 77
            L+ +V +L+ +L   +    QA E     V E+K  L+   +    LE     + S++ +
Sbjct: 573  LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632

Query: 78   LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQS 137
             KE   Q     K       ++ E L+   A+K      +  +LQ  L   +N L + Q 
Sbjct: 633  SKEKVSQLDIQIK-------AKTELLLSAEAAK----TAQRADLQNHLDTAQNALQDKQQ 681

Query: 138  ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
            E  ++ +   ++    Q+ +    +L   +KEYK       + Y  LE++   L+ Q+  
Sbjct: 682  ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK-------EKYLSLEQKTEELEGQIKK 734

Query: 198  LRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER------ 251
            L  + +E +  K +  +  ++   LN+ LE  +R  E+S +QLE   E + + R      
Sbjct: 735  LEADSLEVKASKEQALQDLQQQRQLNTDLE--LRATELS-KQLEMEKEIVSSTRLDLQKK 791

Query: 252  -----EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
                   K  L K+      +   F T      +          E NN  +  V   +  
Sbjct: 792  SEALESIKQKLTKQEEEKQILKQDFETLSQETKI-------QHEELNNRIQTTVTELQKV 844

Query: 307  GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE----KAGL 362
             + K  L  + ST  K+ L+  S SL  +  SE    E QK K  ++ +E+     K  L
Sbjct: 845  KMEKEALMTELST-VKDKLSKVSDSL-KNSKSEFE-KENQKGKAAILDLEKTCKELKHQL 901

Query: 363  LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
               +++T K+ +  + SL +++E   +L   L++++  Q  + + T   NEK+ +    G
Sbjct: 902  QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE-QLIQAQNTLKQNEKE-EQQLQG 959

Query: 423  DYYEVDINGP------EILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
            +  E+  +        E L  +  +AV +  EL  +L+  + T  A+E   A EK     
Sbjct: 960  NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ-QLTQAAQEL--AAEK----- 1011

Query: 477  EGQALTEKVSLLEKASRQDRELLARL-------EKELKKVSDVAGETQGSLSVAQDELVT 529
                  EK+S+L+    + +E   +L       E EL          +  LS+AQ++L++
Sbjct: 1012 ------EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065

Query: 530  FSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKG 589
               ++ N  + +          +  D  ++ Q    R         E   +   ++  K 
Sbjct: 1066 NRNQIGN-QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS 1124

Query: 590  LLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
             LA E                  L S   +  +E  N+ +   ++  Q   LQ   D   
Sbjct: 1125 KLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183

Query: 650  ELSRQRIASQE-LGPAVDKDKEALMEEILKLKSLLST--KREQITTLRTVLKANKQTAEV 706
                Q   +Q+ L   V K++E L +E ++ ++ L +  K +++   +      K T ++
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243

Query: 707  A-----LANLKSKYENEKAMVTETMMK---LRNELKALKEDAATFSSLRAMFATRC---- 754
                  L  +K ++++ +  V+E   +   LR E+  L+         R     RC    
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303

Query: 755  ---DEYITQLDEMQRQL---AAAEDEKKTLNSLLRMAIQQKL 790
               ++  T++ E+QR+L    AA  E    N  L++   Q L
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQAL 1345



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 167/847 (19%), Positives = 340/847 (40%), Gaps = 106/847 (12%)

Query: 6   EEEEYARLVM-EAQPEWL----RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
           E E+Y  L   EA+P+ L     AE++ L  +L E   E     +      ++  QL  +
Sbjct: 112 ELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATE 171

Query: 61  FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK--EQYYVRKV 118
             +++  Y+  RS    L+EA  Q  T       +  ++E ++IQ+  ++  ++  +  V
Sbjct: 172 IADIKSKYDEERS----LREAAEQKVTR----LTEELNKEATVIQDLKTELLQRPGIEDV 223

Query: 119 LELQTELKQLRNVLTN----TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
             L+ EL Q++ ++ N     + E+E+L    ++L+    + E    +LR ++ +     
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283

Query: 175 ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE 234
           A  +Q+  +L+     L ++   L +N ++ E    +++    E       ++  +  K+
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343

Query: 235 ISERQL-------EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSD 287
           +  +QL       E +L  +  E  +K    ++L   +S  ++ Y  HL      L+   
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY-QHLKAEFKQLQQQR 402

Query: 288 DAAEPNN-DAEALVN-------------GFEHGGL-AKLPLDNKTSTPKKEGLAPPSPSL 332
           +  E +    ++ +N             G  HG L  +  L ++    K++ +A     L
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462

Query: 333 --VSDLLSE--LNISEIQ----KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQ 384
             + + L E   N +E+Q    K KQQ  + +  +    A L++ Q  LE     + ++ 
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD 522

Query: 385 EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
           +K+    +NL AL  LQ SKE  + L+ E++ D +      E +      L  K H    
Sbjct: 523 QKI----QNLEAL--LQKSKENISLLEKERE-DLYAKIQAGEGETAVLNQLQEKNHTLQE 575

Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
           +  +L E+LK    +H+  +    ++    +A  +A  ++V  LE +     EL ++L +
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV---NELNSQLNE 632

Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
             +KVS +  + +    +        + + A+L +H+     +T    + D  +E     
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL-----DTAQNALQDKQQE----- 682

Query: 565 GRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREP 624
                                     +  +  +      D      S L S L + + + 
Sbjct: 683 -----------------------LNKITTQLDQVTAKLQDKQ-EHCSQLESHLKEYKEKY 718

Query: 625 MNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLS 684
           +++      +  QIK L+A          Q +   +    ++ D E    E+ K    L 
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK---QLE 775

Query: 685 TKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKED----- 739
            ++E +++ R  L+   +  E ++    +K E EK ++ +    L  E K   E+     
Sbjct: 776 MEKEIVSSTRLDLQKKSEALE-SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834

Query: 740 AATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE-- 797
             T + L+ +   + +  +T+L  ++ +L+   D  K   S      Q+  A    LE  
Sbjct: 835 QTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893

Query: 798 LLELDHE 804
             EL H+
Sbjct: 894 CKELKHQ 900



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 162/855 (18%), Positives = 334/855 (39%), Gaps = 143/855 (16%)

Query: 8    EEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ--------LKL 59
            +E A  V E Q   L++ V  L+ +  +T  E +   E     LEEKH         ++ 
Sbjct: 281  QEVAVYVQELQK--LKSSVNELTQK-NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337

Query: 60   QFEELEVDYEAIRSEM---------------------EQLKEAFGQAHTNHKKVAADGES 98
               + ++D + ++S +                     ++LKE   +  T ++ + A+ + 
Sbjct: 338  TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397

Query: 99   REESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEI 158
                L Q+   KEQ+     L+LQ+E+ QL + L  T+ +   L      LKE  Q    
Sbjct: 398  ----LQQQREEKEQHG----LQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSE 446

Query: 159  QRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKH----EIKR 214
            +       + + + + +RL +   E    +  LQ Q+   +Q   E + L+     +++ 
Sbjct: 447  KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506

Query: 215  LEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
             + + E +  Q+ D  +  +  E  L+++ E +    +++  L  ++       ++   +
Sbjct: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ--AGEGETAVLN 564

Query: 275  HLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL-- 332
             L      L+      +     E L N  E    A+  L ++    K    A     L  
Sbjct: 565  QLQEKNHTLQ-----EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619

Query: 333  ---VSDLLSELNISEIQKLKQQLMQMEREKAGLL-------ATLQDTQKQLEHTRGSLSE 382
               V++L S+LN S+ +K+ Q  +Q++ +   LL       A   D Q  L+  + +L +
Sbjct: 620  ETSVNELNSQLNESK-EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678

Query: 383  QQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
            +Q+++ ++T  L  +  +LQ  +E  + L++          +Y E           KY  
Sbjct: 679  KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK-------EYKE-----------KYLS 720

Query: 442  AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA-----LTEKVSLLEKASRQDR 496
               +  EL  Q+K L +  ++ E + ++E+   + + Q      L  + + L K    ++
Sbjct: 721  LEQKTEELEGQIKKLEA--DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778

Query: 497  ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDY 556
            E+++    +L+K S+     +  L+  ++E     ++   L     + + E  NR+    
Sbjct: 779  EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQT-- 836

Query: 557  YREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP 616
                            T  E +     + + K  L  E           S S  +S    
Sbjct: 837  ----------------TVTELQ----KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876

Query: 617  LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEI 676
              + ++    I +L    ++    LQ  ++ T +        +EL  +++K+KEA  +  
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQMENTLK------EQKELKKSLEKEKEASHQ-- 928

Query: 677  LKLKSLLSTKREQITTLRTVLKANKQTAEVALAN---LKSKYENEKAMV----------- 722
              LK  L++ +EQ+   +  LK N++  +    N   LK   E +K  +           
Sbjct: 929  --LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986

Query: 723  ---TETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLN 779
               TE   KL+ +L    ++ A      ++     ++      ++Q      E E     
Sbjct: 987  LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046

Query: 780  SLLRMAIQQKLALTQ 794
              L+ ++++KL+L Q
Sbjct: 1047 QDLK-SVEEKLSLAQ 1060



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 118/597 (19%), Positives = 246/597 (41%), Gaps = 97/597 (16%)

Query: 7    EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFE---- 62
            +E+Y  L +E + E L  ++K+L  +  E    K QA    L  L+++ QL    E    
Sbjct: 715  KEKY--LSLEQKTEELEGQIKKLEADSLEVKASKEQA----LQDLQQQRQLNTDLELRAT 768

Query: 63   ----ELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESRE------ESLIQESASKEQ 112
                +LE++ E + S    L++      +  +K+    E ++      E+L QE+  + +
Sbjct: 769  ELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828

Query: 113  YYVRKVLELQTELKQLR---------------------NVLTNTQSENER--------LA 143
                ++    TEL++++                     + L N++SE E+        + 
Sbjct: 829  ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888

Query: 144  SVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV----SVLR 199
             + +  KE+   +++Q      + KE K    +  +   +L+ E  S+Q+Q+    + L+
Sbjct: 889  DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948

Query: 200  QNQVEFEGLK---HEIKRLEE----ETEYLNSQLEDAI----RLKEISERQLEEALETLK 248
            QN+ E + L+   +E+K+  E    + E L  +L+ A+     L+   ++QL +A + L 
Sbjct: 949  QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008

Query: 249  TEREQ----KNSLRKELSHYMSINDSFY--TSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
             E+E+    +N+  K    +  +   FY   S L  +   LK  ++      + + + N 
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE-DLISNR 1067

Query: 303  FEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
             + G   KL  + KT+            +L  D  S     ++Q+  + L  +++EK+  
Sbjct: 1068 NQIGNQNKLIQELKTA----------KATLEQD--SAKKEQQLQERCKALQDIQKEKSLK 1115

Query: 363  LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE-------RQTALDNEKD 415
               L + + +L         Q++++T+L E L +  +L++ KE       +Q  +  + +
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS-HKLESIKEITNLKDAKQLLIQQKLE 1174

Query: 416  RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH------EAREAQHAE 469
                 D     V+         K  V   E    +E ++     H      E    +H E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234

Query: 470  EKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
             + +   +  AL E +  ++K  +  +  ++ LEK+   +       + ++   QDE
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 134/721 (18%), Positives = 269/721 (37%), Gaps = 120/721 (16%)

Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
           L+ E++ L+  L   +  +E L    ++ + + Q      G + D   E +  E +L   
Sbjct: 88  LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL--- 144

Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
             E + EN ++++   +  Q   +          L  E   + S+ ++   L+E +E+++
Sbjct: 145 -EEAQTENFNIKQMKDLFEQKAAQ----------LATEIADIKSKYDEERSLREAAEQKV 193

Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
               E L  E      L+ EL     I D        V +  L   +   E   ++E L 
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL-MDNMTLERERESEKL- 251

Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN---------ISEIQKLKQQ 351
                          K    K +     S + +S L SEL          + E+QKLK  
Sbjct: 252 ---------------KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296

Query: 352 LMQMEREKAGLLATL----QD-TQKQLEHTRGSLSEQ-------------QEKVTRLTEN 393
           + ++ ++   L   L    QD T+ + +H   S+S++             Q+  +RL+ +
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356

Query: 394 LSALRRLQAS-KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ 452
            ++L R+     E+  A    K+  S  +  Y  +     + L  +         +L+ +
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ-LQQQREEKEQHGLQLQSE 415

Query: 453 LKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV 512
           +  L S     E Q  E  GR + + Q  +EK+   E+     +  L+RLE++LK+    
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 513 AGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGR 572
           + E Q  L   + +     +E   L         E  N +     + G            
Sbjct: 476 STELQHQLDKTKQQ----HQEQQALQQSTTAKLREAQNDLEQVLRQIG------------ 519

Query: 573 TSPEARGRRSPILLPK-----GLLAPEA----GRADGGTGDSSPSPGSSLPSPLSDPRRE 623
              + + +    LL K      LL  E      +   G G++         + L+  + +
Sbjct: 520 -DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET---------AVLNQLQEK 569

Query: 624 PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALME-EILKLKSL 682
              +   +  + +++K+   +  +  E    ++  Q+      +D+   +E  + +L S 
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629

Query: 683 LSTKREQITTLRTVLKANKQ---TAEVALANLKSKYENEKAMVTETMMKLRNELKALKED 739
           L+  +E+++ L   +KA  +   +AE A    ++  +N        +   + EL      
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL------ 683

Query: 740 AATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELL 799
                          ++  TQLD++  +L   ++    L S L+   ++ L+L Q+ E L
Sbjct: 684 ---------------NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728

Query: 800 E 800
           E
Sbjct: 729 E 729



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 16/170 (9%)

Query: 665  VDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTE 724
            V  +KEALM E+  +K  LS   + +   ++  +   Q  + A+ +L+   +  K  +  
Sbjct: 844  VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903

Query: 725  TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTL----NS 780
             M     E K LK+                +    QL + Q  L   E E++ L    N 
Sbjct: 904  QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963

Query: 781  LLRMAIQQ-----------KLALTQRLEL-LELDHEQTRRGRAKAAPKTK 818
            L + + Q+           K+A+ Q+ EL  +L  + T+  +  AA K K
Sbjct: 964  LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 28/160 (17%), Positives = 73/160 (45%), Gaps = 2/160 (1%)

Query: 1    MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKH-QLKL 59
            + A  E+E+  + +++ Q +    E+K+   E       +I+  E G+   EE   +L +
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241

Query: 60   QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
            Q   L  +   ++ E +  +    +       +  +  +  E+ +Q +  + +  + + L
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGE-IAVLEATVQNNQDERRALLERCL 1300

Query: 120  ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQ 159
            + + E+++L+  +   Q + +   +  QEL   NQ+++I+
Sbjct: 1301 KGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 25/133 (18%), Positives = 58/133 (43%), Gaps = 10/133 (7%)

Query: 631 IAIIRDQIKHLQAAVDR----TTELSR-----QRIASQELGP-AVDKDKEALMEEILKLK 680
           + ++R +++ LQA++      + EL +     Q +  QE  P  +  D  A ++ + +  
Sbjct: 85  VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144

Query: 681 SLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDA 740
               T+   I  ++ + +         +A++KSKY+ E+++      K+    + L ++A
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204

Query: 741 ATFSSLRAMFATR 753
                L+     R
Sbjct: 205 TVIQDLKTELLQR 217


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 115/507 (22%), Positives = 213/507 (42%), Gaps = 46/507 (9%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
            E L    K+L+  L E   E ++A     + LE+ KH+L+ + E+L VD E   +     
Sbjct: 1384 EELEEAKKKLAQRLQEA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA-- 1440

Query: 79   KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV----LTN 134
              A  +   N  K+ A+ + + E    ES S+ +   ++   L TEL +L+N     L +
Sbjct: 1441 --ALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494

Query: 135  TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
             ++      ++ +E+ ++ + +      + +  K  K  EA  ++  S LEE   SL+ +
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554

Query: 195  VSVLRQNQVEFEGLKHEIKR-LEEETEYLNSQLEDAIRLKEISERQLE-------EALET 246
               + + Q+EF  +K EI+R L E+ E +     + +R+ +  +  L+       EAL  
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614

Query: 247  LKTEREQKNSLRKELSH--YMSINDSFYTSHLHVSLDGLKFS-DDAAEPNNDAEALVNGF 303
             K      N +  +LSH   M+         L   L   +   DDA   N+D +  +   
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674

Query: 304  E-HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
            E    L +  L+   +  ++      S  L    L E +   +Q L  Q   +  +K  +
Sbjct: 1675 ERRNNLLQAELEELRAVVEQ---TERSRKLAEQELIETS-ERVQLLHSQNTSLINQKKKM 1730

Query: 363  LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
             A L   Q ++E         +EK  +   + +A+   +  KE+ T+   E+ + + E  
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQ- 1788

Query: 423  DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
                       I   ++ +  AE   L+   K L+      EA+  E +   EAE +   
Sbjct: 1789 ----------TIKDLQHRLDEAEQIALKGGKKQLQKL----EARVRELENELEAEQKRNA 1834

Query: 483  EKVSLLEKASRQDRELLARLEKELKKV 509
            E V  + K+ R+ +EL  + E++ K +
Sbjct: 1835 ESVKGMRKSERRIKELTYQTEEDRKNL 1861



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 179/891 (20%), Positives = 344/891 (38%), Gaps = 139/891 (15%)

Query: 22   LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
            ++ E  RL   L ++   + +  E  +++L+EK+ L+LQ +  + +        +QL + 
Sbjct: 852  MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911

Query: 82   FGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENER 141
              Q     K++    E  EE +  E  +K++    +  EL+ ++  L   L   + E   
Sbjct: 912  KIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970

Query: 142  LASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQN 201
              +  + L E    ++    +L  + K  +    + L D    E++  +L K    L Q 
Sbjct: 971  TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030

Query: 202  QVEFEG---------------------------------------LKHEIKRLEEETEYL 222
              + EG                                       L   +K+ + E   L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090

Query: 223  NSQLED--------AIRLKEISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFY 272
            N+++ED          +LKE+  R  +LEE LE  +T R +   LR +LS          
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR--------- 1141

Query: 273  TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
                   L+ +    + A      +  +N        K+  D + +T + E  A      
Sbjct: 1142 ------ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195

Query: 333  VSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
             +D ++EL   I  +Q++KQ+L   E+EK+     L D    +E          EK+ R 
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKL---EKEKSEFKLELDDVTSNMEQII-KAKANLEKMCRT 1251

Query: 391  TENLSALRRLQASKERQTA--LDNEKDRDSHEDGDYYEVDINGPEILACK-------YHV 441
             E+     R +A + +++   L +++ +   E+G+     ++  E L  +       Y  
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR-QLDEKEALISQLTRGKLTYTQ 1310

Query: 442  AVAE-AGELREQLKALRS-THEAREAQHAEE--KGRYEAEGQALTEKVSLLEKASRQDRE 497
             + +   +L E++KA  +  H  + A+H  +  + +YE E +A  E   +L KA+ +  +
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370

Query: 498  LLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR------ 551
               + E +  + ++   E +  L+    E    +EE     +  C    +T +R      
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQE----AEEAVEAVNAKCSSLEKTKHRLQNEIE 1426

Query: 552  -VMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPG 610
             +M+D  R     A         + + + R    +L +     E  +++    +SS    
Sbjct: 1427 DLMVDVERSNAAAA---------ALDKKQRNFDKILAEWKQKYEESQSE---LESSQKEA 1474

Query: 611  SSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKE 670
             SL + L   +         +   + + K+LQ   +  ++L+ Q  +S +    ++K ++
Sbjct: 1475 RSLSTELFKLKNAYEESLEHLETFKRENKNLQ---EEISDLTEQLGSSGKTIHELEKVRK 1531

Query: 671  ALMEEILKLKSLL-----STKREQITTLRTVLKANKQTAEV--ALANLKSKYENEKAMVT 723
             L  E ++L+S L     S + E+   LR  L+ N+  AE+   LA    + E  K    
Sbjct: 1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591

Query: 724  ETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLR 783
              +  L+  L A          ++       +E   QL    R  A A+ + K+L SLL+
Sbjct: 1592 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651

Query: 784  MA-------------IQQKLALTQR--------LELLELDHEQTRRGRAKA 813
                           +++ +A+ +R        LE L    EQT R R  A
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1702



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 50/250 (20%), Positives = 112/250 (44%), Gaps = 13/250 (5%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
            +++A+ E LRA V++         +E I+ +E    +  +   L  Q ++++ D   +++
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739

Query: 74   EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
            E+E+  +    A    KK   D     E L +E  +   +  R    ++  +K L++ L 
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLD 1798

Query: 134  NTQS-----ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
              +        ++L  +   ++E+   +E ++ R  + +K  +  E R+ +   + EE+ 
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDR 1858

Query: 189  ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
             +L +   ++ + Q++ +  K   ++ EE  E  N+ L    ++    + +L+EA E   
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYK---RQAEEAEEQANTNLSKFRKV----QHELDEAEERAD 1911

Query: 249  TEREQKNSLR 258
                Q N LR
Sbjct: 1912 IAESQVNKLR 1921



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 56/256 (21%), Positives = 119/256 (46%), Gaps = 35/256 (13%)

Query: 12   RLVMEAQPEW--LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYE 69
            R+  EAQ +   L++ +K    +L +  R      E  +A++E ++ L      L+ + E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNL------LQAELE 1686

Query: 70   AIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLR 129
             +R+ +EQ + +        +K+A      E+ LI E++ + Q    +   L  + K++ 
Sbjct: 1687 ELRAVVEQTERS--------RKLA------EQELI-ETSERVQLLHSQNTSLINQKKKMD 1731

Query: 130  NVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENI 189
              L+  Q+E E      +  +E  +        + +++K+ +   A L +    +E+   
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791

Query: 190  SLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE-------DAIRLKEISERQLEE 242
             LQ ++      Q+  +G K ++++LE     L ++LE       ++++    SER+++E
Sbjct: 1792 DLQHRLD--EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849

Query: 243  ALETLKTEREQKNSLR 258
               T +TE ++KN LR
Sbjct: 1850 L--TYQTEEDRKNLLR 1863


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 168/812 (20%), Positives = 332/812 (40%), Gaps = 85/812 (10%)

Query: 45   EYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLI 104
            +  L++L+E   L+   E+LEV     + E+  LKE FG     H+K     E +     
Sbjct: 532  DMSLSLLQEISSLQ---EKLEVTRTDHQREITSLKEHFGAREETHQK-----EIKALYTA 583

Query: 105  QESASKEQYYVRKVLELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNVEIQRGRL 163
             E  SKE   ++  LE     K+  +V+   +S+ E  +AS  Q ++E+  +     G  
Sbjct: 584  TEKLSKENESLKSKLEHAN--KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 641

Query: 164  RDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE----IKRLEEET 219
              +  E K +  ++  DY   E EN+  Q Q S    +  E E L+ +    IK  E   
Sbjct: 642  TAEFAELKTQIEKMRLDYQH-EIENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSL 699

Query: 220  EYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLH-- 277
            E + S+L+ A     +        L+  + + ++   L+ + +    + D+F TS L   
Sbjct: 700  EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF-TSQLKAT 758

Query: 278  ----VSLDGLKFSDDAAEP-----NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPP 328
                + LD L+ +    +          EA     +H  + K    +K S+  +E     
Sbjct: 759  EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE---LQ 815

Query: 329  SPSLVSDLLSELNISEIQKLKQQL---MQMEREK-AGLLATLQDTQKQLEHTRGSLSEQQ 384
               L    L E N+SE+ ++K+ L   +Q+ +EK A         Q+ ++ T   L +++
Sbjct: 816  GRELKLTNLQE-NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 874

Query: 385  EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI---------NGPEIL 435
            E+   L+ +L  LR   A  E +    +E++    +  +  E DI         N  ++ 
Sbjct: 875  EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 934

Query: 436  ACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQD 495
                 + + E      QLK  ++   A   Q + E    +AE Q+  E     E+  ++ 
Sbjct: 935  KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE-QSQQEAAKKHEEEKKEL 993

Query: 496  RELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLD 555
               L+ LEK+++   +   E +     A  E  T  EE+            +   + +LD
Sbjct: 994  ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL-----------QNLQKTLLD 1042

Query: 556  YYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
               + +G     S   +   E R +       K   A  A  A       +     +L S
Sbjct: 1043 TEDKLKGAREENSGLLQELEELRKQAD-----KAKAAQTAEDAMQIMEQMTKEKTETLAS 1097

Query: 616  PLSDPRREPMNIYNLIAIIRD-QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALME 674
             L D ++    + N +  +++  +K+++       EL++    S+EL    ++  E   +
Sbjct: 1098 -LEDTKQTNAKLQNELDTLKENNLKNVE-------ELNK----SKELLTVENQKMEEFRK 1145

Query: 675  EILKLKSLLSTKREQITTLR--TVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNE 732
            EI  LK   + K +Q++ L+   V  A +            K E E++++   +++++  
Sbjct: 1146 EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1205

Query: 733  ----LKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK---KTLNSLLRMA 785
                +K   E+ A+     ++ +    E   +L++++ ++     E    K+L+S+++  
Sbjct: 1206 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTL 1265

Query: 786  IQQKLALTQRLELLELDHEQTRRGRAKAAPKT 817
               K+ L  +++ LEL  ++ +R  + ++  T
Sbjct: 1266 ESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 158/821 (19%), Positives = 335/821 (40%), Gaps = 110/821 (13%)

Query: 69   EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
            EA++ + + +++   +      +VA    S    + QE A     + + VLEL+ ++ QL
Sbjct: 355  EALKEKQQHIEQLLAERDLERAEVAK-ATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413

Query: 129  RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
            R ++     E   L +   +L+E  + VE  + R+ ++       E +   +++ ++E  
Sbjct: 414  RTMVEAADREKVELLN---QLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470

Query: 189  ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE----------- 237
             SL  + +   + Q E E  +  +  + E++  +  + + A+R++E++E           
Sbjct: 471  QSLLFEKTKADKLQRELEDTR--VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528

Query: 238  -------------RQLEEALETLKTEREQK-NSLR-----KELSHYMSINDSFYTSHLHV 278
                           L+E LE  +T+ +++  SL+     +E +H   I  + YT+   +
Sbjct: 529  GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK-ALYTATEKL 587

Query: 279  SLDGLKFS---DDAAEPNNDAEALVNGFEHGGLA---KLPLDNKTSTPKKEGLAPPSPSL 332
            S +        + A + N+D  AL        +A   +   + K S  K  G      + 
Sbjct: 588  SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 647

Query: 333  VSDLLSELNIS---EIQKLKQQ--------LMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
            +   + ++ +    EI+ L+ Q          +ME  +A L+  +++ +  LE  R  L 
Sbjct: 648  LKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707

Query: 382  EQQEKVTRLTENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKY 439
            + +++   L E    L +LQ +  K ++  +   K  +  +  D +   +   E      
Sbjct: 708  KAEDQ--HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 765

Query: 440  HVAVAEAGELREQLKALRSTHEAREAQ--HAE-EKGRYEAEGQALTEKVSLLEKASRQDR 496
                  + E + ++K LR   EA E Q  H E EK    ++  ++T ++        Q R
Sbjct: 766  DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL--------QGR 817

Query: 497  EL-LARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNN------ETP 549
            EL L  L++ L +VS V    +  L + +++    SEE  ++   +    N      E  
Sbjct: 818  ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877

Query: 550  NRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSP 609
            N +  D  +  +  A   +       E   R   ++  K  L  +       +GD+S S 
Sbjct: 878  NMLSSDLEKLRENLADMEA----KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNS-SQ 932

Query: 610  GSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDK 669
             + +   L    R+   +   +    +    LQ +++  T  + Q  + QE     +++K
Sbjct: 933  LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEK 990

Query: 670  EALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKL 729
            + L  ++  L+  + T   Q   L       K   E A +  K+K+E     + +T++  
Sbjct: 991  KELERKLSDLEKKMETSHNQCQEL-------KARYERATSETKTKHEEILQNLQKTLLDT 1043

Query: 730  RNELKALKEDAATF---------SSLRAMFATRCDEYITQLDEMQRQ----LAAAEDEKK 776
             ++LK  +E+ +            + +A  A   ++ +  +++M ++    LA+ ED K+
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103

Query: 777  T-------LNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
            T       L++L    ++    L +  ELL +++++    R
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 106/546 (19%), Positives = 207/546 (37%), Gaps = 57/546 (10%)

Query: 7    EEEYARLVMEAQPEWLRAEVKRLSHELA---ETTREKIQAAEYGLAVLEEKHQLKLQFEE 63
            +++  R     + E LRA++ ++  E     E  R K+  AE    V  E    KLQ  E
Sbjct: 669  QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE 728

Query: 64   LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
            ++V       E+E L     QA  N +    D  + +    +E         +   E ++
Sbjct: 729  IKV------KELEVL-----QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 777

Query: 124  ELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGR-LRDDIKEYKFREARLLQDYS 182
            E+K+LR  L   + + + L        EI +N E  +   +  +++  + +   L ++ S
Sbjct: 778  EMKKLRQQLEAAEKQIKHL--------EIEKNAESSKASSITRELQGRELKLTNLQENLS 829

Query: 183  ELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
            E+ +   +L+K++ +L++   E       ++R  +ET     Q E+   +      +L E
Sbjct: 830  EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889

Query: 243  ALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDG----LKFSDDAAEPNNDAEA 298
             L  ++ +  +K+   ++L       ++     + +S D      K +D+      D E 
Sbjct: 890  NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949

Query: 299  LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
            L          KL   N+ +            S +   + ++ +   Q  ++   + E E
Sbjct: 950  L--------QLKLTKANENA------------SFLQKSIEDMTVKAEQSQQEAAKKHEEE 989

Query: 359  KAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE---KD 415
            K  L   L D +K++E +     E + +  R T              ++T LD E   K 
Sbjct: 990  KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049

Query: 416  RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYE 475
                  G   E++    +    K      +A ++ EQ+   ++   A      +   + +
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109

Query: 476  AEGQALTEKVSLLEKASRQDRELLA-------RLEKELKKVSDVAGETQGSLSVAQDELV 528
             E   L E      +   + +ELL           KE++ +   A +    LS  Q+E V
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169

Query: 529  TFSEEL 534
              +EEL
Sbjct: 1170 KLAEEL 1175



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 101/495 (20%), Positives = 195/495 (39%), Gaps = 53/495 (10%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
            E L  E++ L  + AE + E +         + + HQ + QF  L  D E +R  +  ++
Sbjct: 836  ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME 895

Query: 80   EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
              F            + + REE LI+     E      +        QL  +    + + 
Sbjct: 896  AKF-----------REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 944

Query: 140  ERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL-EEENISLQKQVSVL 198
              +  +  +L + N+N       L+  I++   +  +  Q+ ++  EEE   L++++S L
Sbjct: 945  RDVEELQLKLTKANENASF----LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000

Query: 199  RQNQVEFEGLKHEIK-RLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSL 257
             +          E+K R E  T    ++ E+ +   +  ++ L +  + LK  RE+ + L
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEIL---QNLQKTLLDTEDKLKGAREENSGL 1057

Query: 258  RKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT 317
             +EL       D         + D ++  +   +   +  A     E        L N+ 
Sbjct: 1058 LQELEELRKQADK--AKAAQTAEDAMQIMEQMTKEKTETLA---SLEDTKQTNAKLQNEL 1112

Query: 318  STPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTR 377
             T K+  L               N+ E+ K K +L+ +E +K        +T KQ    +
Sbjct: 1113 DTLKENNLK--------------NVEELNKSK-ELLTVENQKMEEFRKEIETLKQAAAQK 1157

Query: 378  G-SLSEQQEKVTRLTENLSALR----RLQASKERQTALDNE----KDRDSH--EDGDYYE 426
               LS  QE+  +L E L   R      Q  +E ++ L+N+    K R+S   +D D  +
Sbjct: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217

Query: 427  VDI-NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKV 485
              +     I +       AE  +LR ++  LR  + + ++ H+  +   E++   L  KV
Sbjct: 1218 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ-TLESDKVKLELKV 1276

Query: 486  SLLEKASRQDRELLA 500
              LE   ++++  L+
Sbjct: 1277 KNLELQLKENKRQLS 1291



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 40/207 (19%), Positives = 97/207 (46%), Gaps = 9/207 (4%)

Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPAVDKDKEALMEEILK 678
           ++E   +Y     +  + + L++ ++   + +   IA    +L  A+   ++A+ E  + 
Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633

Query: 679 LKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL-KALK 737
               L T+  +   L+T ++  +   +  + NL+++ ++E+A   + M  LR +L K +K
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693

Query: 738 EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL---TQ 794
           E   +  ++R+      D+++ ++++   +L  AE + K L  L     +Q   +   T 
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753

Query: 795 RLELLE---LDHEQTRRGRAKAAPKTK 818
           +L+  E   LD +  R+  ++   + K
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMK 780



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 19/135 (14%)

Query: 379 SLSEQQEKVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILAC 437
           S+S +  +   LTE  S   R++  +   Q AL   K++  H +    E D+   E+   
Sbjct: 325 SVSSRPSRTGLLTETSSRYARKISGTTALQEAL---KEKQQHIEQLLAERDLERAEVAKA 381

Query: 438 KYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRE 497
             HV     GE+ ++L   R  H+    QH  E    EA+   L    +++E A R+  E
Sbjct: 382 TSHV-----GEIEQELALARDGHD----QHVLE---LEAKMDQLR---TMVEAADREKVE 426

Query: 498 LLARLEKELKKVSDV 512
           LL +LE+E +KV D+
Sbjct: 427 LLNQLEEEKRKVEDL 441


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 159/818 (19%), Positives = 318/818 (38%), Gaps = 142/818 (17%)

Query: 22   LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE----LEVDYEAIRSEMEQ 77
            L  E K    ++ E  ++  QA E     LE+  ++K   E+    LE +   + +E++ 
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235

Query: 78   LKEAFGQAHTNHKKVAA----------DGES-REE----------------SLIQESASK 110
            L +  G +    KKV A          +GE  R E                 L+ +S SK
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295

Query: 111  EQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEY 170
                 +    L+++L+  + +L   Q EN +  S++ +LK+    VE ++   R+ ++E 
Sbjct: 1296 SSKLTKDFSALESQLQDTQELL---QEENRQKLSLSTKLKQ----VEDEKNSFREQLEEE 1348

Query: 171  KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEG---LKHEIKR-LEEETEYLNSQL 226
            +  EA+       LE++  +L  QV+ +++   +  G      E+KR L+++ E L+ + 
Sbjct: 1349 E--EAK-----HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401

Query: 227  EDAI-------RLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
            E+ +       + K   +++L++ L  L  +R+   +L K+   +  +     T     +
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461

Query: 280  LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
             +  +   +A E    A +L    E     K  L+      + E         + DL+S 
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE---------MEDLMSS 1512

Query: 340  LNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR 399
             +      + + + ++E+ K  L   +++ + QLE     L   ++   RL  NL A++ 
Sbjct: 1513 KD-----DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK- 1566

Query: 400  LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRST 459
              A  ER     +E+  +  +              L  +     AE  + R+Q     + 
Sbjct: 1567 --AQFERDLQGRDEQSEEKKKQ-------------LVRQVREMEAELEDERKQRSMAVAA 1611

Query: 460  HEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV---AGET 516
             +  E    + +   ++  +   E +  L K   Q ++ +  L+       ++   A E 
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671

Query: 517  QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
            +  L   + E++   EELA                                    R   +
Sbjct: 1672 EKKLKSMEAEMIQLQEELA---------------------------------AAERAKRQ 1698

Query: 577  ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
            A+  R         LA E   +  G G  +      L + ++    E         +I D
Sbjct: 1699 AQQERDE-------LADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750

Query: 637  QIKHLQAAVDR-TTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRT 695
            ++K     +D+  T+L+ +R  +Q       K++ A  +   + K L    +E   T+++
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQ-------KNENARQQLERQNKELKVKLQEMEGTVKS 1803

Query: 696  VLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR---AMFAT 752
              KA+    E  +A L+ + +NE         ++R   K LK+        R     +  
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863

Query: 753  RCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
            + D+  T+L +++RQL  AE+E +  N+  R  +Q++L
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANA-SRRKLQREL 1900



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 128/559 (22%), Positives = 228/559 (40%), Gaps = 101/559 (18%)

Query: 9    EYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAE--YGLAVLEEKHQLKL------- 59
            E  ++++E Q   L  E K L   +AE T    +  E    LA L+ KH+  +       
Sbjct: 977  EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERL 1036

Query: 60   -----QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESA 108
                 Q +ELE     +  +   L +   +      ++      +EE L      ++E A
Sbjct: 1037 RREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096

Query: 109  SKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRD--- 165
            +++   ++K+ EL++++ +L+  L   +SE        ++ +++ + +E  +  L D   
Sbjct: 1097 AQKNMALKKIRELESQISELQEDL---ESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153

Query: 166  ------DIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEET 219
                  +++  + +E  +L+    LEEE  + + Q+  +RQ        KH      +  
Sbjct: 1154 STAAQQELRSKREQEVNILK--KTLEEEAKTHEAQIQEMRQ--------KH-----SQAV 1198

Query: 220  EYLNSQLEDAIRLKEISERQLEEALETLKTER-EQKNSLRKELSHYMSINDSFYTSHLHV 278
            E L  QLE   R+K      LE+A +TL+ ER E  N ++  L                +
Sbjct: 1199 EELAEQLEQTKRVK----ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 279  SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT-----STPKKEGLAPPSPSLV 333
                +KF++        A+ +          ++ LDN T     S  K   L     +L 
Sbjct: 1255 QELQVKFNEGERVRTELADKVTK-------LQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307

Query: 334  S------DLLSELN---ISEIQKLKQ----------QLMQ-------MEREKAGLLATLQ 367
            S      +LL E N   +S   KLKQ          QL +       +E++ A L A + 
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367

Query: 368  DTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDYY 425
            D +K++E + G L   +E   +L ++L  L   Q  +E+  A D  EK +    ++ D  
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLS--QRHEEKVAAYDKLEKTKTRLQQELDDL 1425

Query: 426  EVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKV 485
             VD++     AC       +  +L  + K +        A++AEE+ R EAE +    K 
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTI-------SAKYAEERDRAEAEAREKETKA 1478

Query: 486  SLLEKASRQDRELLARLEK 504
              L +A  +  E  A LE+
Sbjct: 1479 LSLARALEEAMEQKAELER 1497



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 161/859 (18%), Positives = 335/859 (38%), Gaps = 131/859 (15%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKH-QLKLQFEELEVDYEAIRSEMEQL 78
            +W R   K           E++ A E  L  + EK    + +  E+E     + +E  QL
Sbjct: 826  QWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQL 885

Query: 79   KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
            +E   QA T   ++ A+ E     L     +K+Q       +L+  +++      + Q+E
Sbjct: 886  QEQL-QAET---ELCAEAEELRARL----TAKKQELEEICHDLEARVEEEEERCQHLQAE 937

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
             +++    QEL+E  +  E  R +L+ +    + +  +L ++   LE++N  L K+  +L
Sbjct: 938  KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997

Query: 199  RQNQVEF-------EGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
                 EF       E     + +L+ + E + + LE+ +R +E   ++LE+    L+ + 
Sbjct: 998  EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 252  EQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN------NDAEALVNGFE 304
               +    EL +    +          +     +  ++AA+ N       + E+ ++  +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117

Query: 305  HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL- 363
                ++    NK    K++ L     +L ++L   L+ +  Q   Q+L     ++  +L 
Sbjct: 1118 EDLESERASRNKAEKQKRD-LGEELEALKTELEDTLDSTAAQ---QELRSKREQEVNILK 1173

Query: 364  ATLQDTQKQLEHTRGSLSEQQEK----VTRLTENLSALRRLQASKER-QTALDNEKDRDS 418
             TL++  K  E     + E ++K    V  L E L   +R++A+ E+ +  L+NE+   +
Sbjct: 1174 KTLEEEAKTHE---AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230

Query: 419  HE---------DGDYYEVDINGP-EILACKYHVAVAEAGELREQLKALRSTHEAREAQHA 468
            +E         D ++    +    + L  K++       EL +++  L+   +      +
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290

Query: 469  EEKGRYEAEGQALTEKVSLLEKASRQDRELLAR-------LEKELKKVSDVAGETQGSLS 521
            +     +++   LT+  S LE   +  +ELL         L  +LK+V D     +  L 
Sbjct: 1291 QS----DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346

Query: 522  VAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRR 581
              ++      +++A L+  V             D  ++ +   G       T+ E + + 
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVA------------DMKKKMEDSVGCL----ETAEEVKRK- 1389

Query: 582  SPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHL 641
                L K L                          LS    E +  Y+ +   + +++  
Sbjct: 1390 ----LQKDL------------------------EGLSQRHEEKVAAYDKLEKTKTRLQ-- 1419

Query: 642  QAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANK 701
            Q   D   +L  QR ++  L     + K+   +++L  +  +S K  +           K
Sbjct: 1420 QELDDLLVDLDHQRQSACNL-----EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 702  QTAEVALANLKSKYENEKAMVTETMMKLRNELKAL---KEDAA----TFSSLRAMFATRC 754
            +T  ++LA    +   +KA +     + R E++ L   K+D           +     + 
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534

Query: 755  DEYITQLDEMQRQLAAAEDEKKTLNSLLR---------------MAIQQKLALTQRLELL 799
            +E  TQL+E++ +L A ED K  L   L+                + ++K  L +++  +
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594

Query: 800  ELDHEQTRRGRAKAAPKTK 818
            E + E  R+ R+ A    K
Sbjct: 1595 EAELEDERKQRSMAVAARK 1613



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 116/546 (21%), Positives = 214/546 (39%), Gaps = 86/546 (15%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSH---------ELAETTREKIQAAEYGLAVLEE--- 53
            EEEE A+  +E Q   L A+V  +           E AE  + K+Q    GL+   E   
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405

Query: 54   ---------KHQLKLQFEELEVDYEAIRSE---MEQLKEAFGQAHTNHKKVAA---DGES 98
                     K +L+ + ++L VD +  R     +E+ ++ F Q     K ++A   +   
Sbjct: 1406 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465

Query: 99   REESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEI 158
            R E+  +E  +K     R + E   +  +L  +    ++E E L S   ++ +    +E 
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525

Query: 159  QRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEE 218
             +  L   ++E K +   L  +    E+  + L+  +  ++    +FE    +++  +E+
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK---AQFE---RDLQGRDEQ 1579

Query: 219  TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHV 278
            +E    QL   +R       ++E  LE  + +R    + RK+L                +
Sbjct: 1580 SEEKKKQLVRQVR-------EMEAELEDERKQRSMAVAARKKLE---------------M 1617

Query: 279  SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNK--------TSTPKKEGLAPPSP 330
             L  L+   D+A  N D EA+        L KL    K        T   ++E LA    
Sbjct: 1618 DLKDLEAHIDSANKNRD-EAIKQ------LRKLQAQMKDCMRELDDTRASREEILAQAKE 1670

Query: 331  SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
            +     L  +    IQ L+++L   ER K        +   ++ ++ G  +   E+  RL
Sbjct: 1671 N--EKKLKSMEAEMIQ-LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727

Query: 391  TENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR 450
               ++ L      ++  T L N++ + ++   D    D+N     A K   A  +     
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787

Query: 451  EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE-------KASRQDRELLARLE 503
            ++LK         +      K +Y+A   AL  K++ LE       K  +   + + R E
Sbjct: 1788 KELKV------KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841

Query: 504  KELKKV 509
            K+LK V
Sbjct: 1842 KKLKDV 1847



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 49/254 (19%), Positives = 115/254 (45%), Gaps = 24/254 (9%)

Query: 22   LRAEVKRLSHELAETTREKIQAAEY--------------GLAVLEEKHQLKLQFEELEVD 67
            + AE+ +L  ELA   R K QA +               G   LEEK +L+ +  +LE +
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737

Query: 68   YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQ 127
             E  +   E + +   +A+    ++  D  + E S  Q++ +  Q   R+  EL+ +L++
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTD-LNLERSHAQKNENARQQLERQNKELKVKLQE 1796

Query: 128  LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
            +   + +    +  + ++  ++ ++ + ++ +    +   K+ +  E +L     ++++E
Sbjct: 1797 MEGTVKSKYKAS--ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854

Query: 188  NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
              + ++      +     + LK +++  EEE +  N+        +   +R+LE+A ET 
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANAS-------RRKLQRELEDATETA 1907

Query: 248  KTEREQKNSLRKEL 261
                 + +SL+ +L
Sbjct: 1908 DAMNREVSSLKNKL 1921


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 175/882 (19%), Positives = 341/882 (38%), Gaps = 109/882 (12%)

Query: 16   EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
            E +   ++ E  R+   L ++   + +  E  +++L+EK+ L+LQ +  + +        
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907

Query: 76   EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
            +QL +   Q     K++    E  EE +  E  +K++    +  EL+ ++  L   L   
Sbjct: 908  DQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKV 966

Query: 136  QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
            + E     +  + L E    ++    +L  + K  +    + L D    E++  SL K  
Sbjct: 967  EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSK 1026

Query: 196  SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQLEEALETLK 248
              L Q   + EG   + K++  + E    +LE  ++L + S       + QLEE L+  +
Sbjct: 1027 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKE 1086

Query: 249  TEREQKNS-----------LRKELSHYMSINDSF----------------YTSHLHVSLD 281
             +  Q+NS           L+K+L    +  +                    S L   L+
Sbjct: 1087 FDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE 1146

Query: 282  GLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL- 340
             +    + A      +  +N        K+  D + +T + E  A       +D ++EL 
Sbjct: 1147 EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206

Query: 341  -NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR 399
              I  +Q++KQ+L   E+EK+     L D    +E          EKV+R  E+ +   R
Sbjct: 1207 EQIDNLQRVKQKL---EKEKSEFKLELDDVTSNMEQII-KAKANLEKVSRTLEDQANEYR 1262

Query: 400  LQASKERQTALD--NEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
            ++  + +++  D   ++ +   E+G+          +++      ++   ++ +  + L 
Sbjct: 1263 VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE 1322

Query: 458  STHEAREA-QHAEEKGR---------YEAEGQALTEKVSLLEKASRQDRELLARLEKELK 507
               +A+ A  HA +  R         YE E +A  E   +L KA+ +  +   + E +  
Sbjct: 1323 EEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1382

Query: 508  KVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR-------VMLDYYREG 560
            + ++   E +  L+    + +  +EE     +  C    +T +R       +M+D  R  
Sbjct: 1383 QRTEELEEAKKKLA----QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438

Query: 561  QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
               A         + + + R    +L +     E  +++    +SS     SL + L   
Sbjct: 1439 AAAA---------ALDKKQRNFDKILAEWKQKYEESQSE---LESSQKEARSLSTELFKL 1486

Query: 621  RREPMNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQELGPAVDKDKEALMEEILKL 679
            +         +   + + K+LQ  + D T +L        EL    +K ++ L  E L+L
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL----EKVRKQLEVEKLEL 1542

Query: 680  KSLL-----STKREQITTLRTVLKANKQTAEV--ALANLKSKYENEKAMVTETMMKLRNE 732
            +S L     S + E+   LR  L+ N+  AE+   LA    + E  K      +  L+  
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602

Query: 733  LKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMA------- 785
            L A          ++       +E   QL    R  A A+ + K+L SLL+         
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662

Query: 786  ------IQQKLALTQR--------LELLELDHEQTRRGRAKA 813
                  +++ +A+ +R        LE L    EQT R R  A
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1704



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 116/507 (22%), Positives = 210/507 (41%), Gaps = 46/507 (9%)

Query: 20   EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
            E L    K+L+  L +   E ++A     + LE+ KH+L+ + E+L VD E   +     
Sbjct: 1386 EELEEAKKKLAQRLQDA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA-- 1442

Query: 79   KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
              A  +   N  K+ A+ + + E    ES S+ +   ++   L TEL +L+N    +   
Sbjct: 1443 --ALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496

Query: 139  NERLASVAQELKEINQNVEIQRGRLRDDIKEY----KFREARLLQDYSELEEENISLQKQ 194
             E      + L+E   ++  Q G    ++ E     K  E   L+  S LEE   SL+ +
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556

Query: 195  VSVLRQNQVEFEGLKHEIKR-LEEETEYL------NSQLEDAIRLK-EISERQLEEALET 246
               + + Q+EF  +K EI+R L E+ E +      + ++ D+++   +   R   E L  
Sbjct: 1557 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616

Query: 247  LKTEREQKNSLRKELSH--YMSINDSFYTSHLHVSLDGLKFS-DDAAEPNNDAEALVNGF 303
             K      N +  +LSH   M+         L   L   +   DDA   N+D +  +   
Sbjct: 1617 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676

Query: 304  E-HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
            E    L +  L+   +  ++      S  L    L E +   +Q L  Q   +  +K  +
Sbjct: 1677 ERRNNLLQAELEELRAVVEQ---TERSRKLAEQELIETS-ERVQLLHSQNTSLINQKKKM 1732

Query: 363  LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
             + L   Q ++E         +EK  +   + +A+   +  KE+ T+   E+ + + E  
Sbjct: 1733 ESDLTQLQSEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQ- 1790

Query: 423  DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
                       I   ++ +  AE   L+   K L+      EA+  E +G  EAE +   
Sbjct: 1791 ----------TIKDLQHRLDEAEQIALKGGKKQLQKL----EARVRELEGELEAEQKRNA 1836

Query: 483  EKVSLLEKASRQDRELLARLEKELKKV 509
            E V  + K+ R+ +EL  + E++ K +
Sbjct: 1837 ESVKGMRKSERRIKELTYQTEEDKKNL 1863



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 166/850 (19%), Positives = 339/850 (39%), Gaps = 85/850 (10%)

Query: 22   LRAEVKRLSHELAETTREKIQAAEYGLAVLE-EKHQLKLQFEELEVDY---EAIRSEMEQ 77
            L A+ ++L  E +E  ++ I   E  LA +E EKH  + + + L  +    + I +++ +
Sbjct: 938  LTAKKRKLEDECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996

Query: 78   LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQS 137
             K+A  +AH      A D    EE  +   +  +    ++V +L+  L+Q + V  + + 
Sbjct: 997  EKKALQEAHQQ----ALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052

Query: 138  ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
               +L    +  +E   ++E  + +L + +K+ +F    + Q  S++E+E +   +    
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD---INQQNSKIEDEQVLALQLQKK 1109

Query: 198  LRQNQVEFEGLKHEI---KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK 254
            L++NQ   E L+ E+   +    + E L S L  +  L+EISER LEEA      + E  
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDL--SRELEEISER-LEEAGGATSVQIEMN 1166

Query: 255  NSLRKELSHY-MSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE----HGGLA 309
                 E       + ++        +    K +D  AE     + L    +         
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226

Query: 310  KLPLDNKTSTPK-----KEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLA 364
            KL LD+ TS  +     K  L   S +L  D  +E  + ++++ ++ L     ++A L  
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTL-EDQANEYRV-KLEEAQRSLNDFTTQRAKLQT 1284

Query: 365  TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDG- 422
               +  +QLE     +S+        T+ +  L+R L+   + + AL +      H+   
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344

Query: 423  --DYYEVDINGPEILACKYHVAVAEAGELREQLK--ALRSTHEAREAQHAEEKGRYEAEG 478
              + YE +      L      A +E  + R + +  A++ T E  EA+    +   +AE 
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1404

Query: 479  --QALTEKVSLLEKAS--------------RQDRELLARLEKELKKVSDVAGETQGSLSV 522
              +A+  K S LEK                 +     A L+K+ +    +  E +     
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464

Query: 523  AQDELVTFSEELANLYHHVCMCNN---------ETPNRVMLDYYREGQGGAGRTSPGGRT 573
            +Q EL +  +E  +L   +    N         ET  R   +   E      +   GG+ 
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524

Query: 574  SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAI 633
              E    R  + + K  L      A+           +SL        R  +    + A 
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAE-----------ASLEHEEGKILRAQLEFNQIKAE 1573

Query: 634  IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
            I  ++      +++  + + QR+    L  ++D +  +   E+L++K  +     ++   
Sbjct: 1574 IERKLAEKDEEMEQ-AKRNHQRVV-DSLQTSLDAETRS-RNEVLRVKKKMEGDLNEMEI- 1629

Query: 694  RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA---LKEDAATFSSLRAMF 750
              +  AN+  AE      + + ++ ++++ +T ++L + ++A   LKE+ A       + 
Sbjct: 1630 -QLSHANRMAAEA-----QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683

Query: 751  ATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
                +E    +++ +R    AE E    +  +++   Q  +L  + + +E D  Q +   
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743

Query: 811  AKAAPKTKPA 820
             +A  + + A
Sbjct: 1744 EEAVQECRNA 1753



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 165/876 (18%), Positives = 329/876 (37%), Gaps = 123/876 (14%)

Query: 6    EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAE----------YGLAVLEEKH 55
            E+E+  R+ +E     L  ++K     + +   +K+Q  E             + +E++ 
Sbjct: 1041 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ 1100

Query: 56   QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL---IQESASKEQ 112
             L LQ ++   + +A   E+E+  EA   A    +K+ +D     E +   ++E+     
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160

Query: 113  YYVRKVLELQTELKQLRNVLTNTQSENERLA---------SVAQ------ELKEINQNVE 157
              +    + + E +++R  L     ++E  A         SVA+       L+ + Q +E
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220

Query: 158  IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE 217
             ++   + ++ +      ++++  + LE+ + +L+ Q +  R    E +   ++      
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280

Query: 218  ETEYLNSQLEDAIRLKEISERQL-------EEALETLKTEREQKNSLRKELSHYMSINDS 270
            + +  N +L   +  KE    QL        + +E LK + E++   +  L+H +     
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ---- 1336

Query: 271  FYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSP 330
                                   +D + L   +E    AK  L    S    E       
Sbjct: 1337 --------------------SARHDCDLLREQYEEETEAKAELQRVLSKANSE------- 1369

Query: 331  SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
              V+   ++     IQ+ +    ++E  K  L   LQD ++ +E      S  ++   RL
Sbjct: 1370 --VAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRL 1423

Query: 391  TENLSALR-RLQASKERQTALDNEK---DRDSHEDGDYYEVDINGPEILACKYHVAVAEA 446
               +  L   ++ S     ALD ++   D+   E    YE           +   +  EA
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-------QSELESSQKEA 1476

Query: 447  GELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKEL 506
              L  +L  L++ +E    +H E    ++ E + L E++S L +   +  + +  LEK  
Sbjct: 1477 RSLSTELFKLKNAYE-ESLEHLE---TFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532

Query: 507  KKVSDVAGETQGSLSVAQDELVTFSEEL--ANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
            K++     E Q +L  A+  L     ++  A L  +      E       +   + +   
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592

Query: 565  GRTSPGGRTSPEARGR-RSPILLPKGLLAPEAGRAD------GGTGDSSPSPGSSLPSPL 617
             R     +TS +A  R R+ +L  K  +  +    +            +     SL S L
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1652

Query: 618  SDPR-------REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKE 670
             D +       R   ++   IAI+  +   LQA ++    +  Q   S++L    +++  
Sbjct: 1653 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL---AEQELI 1709

Query: 671  ALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLR 730
               E +  L S  ++   Q   + + L   +   E A+   ++  E  K  +T+  M + 
Sbjct: 1710 ETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAM-MA 1768

Query: 731  NELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
             ELK  ++ +A    ++        +   +LDE ++   A +  KK L         QKL
Sbjct: 1769 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGGKKQL---------QKL 1817

Query: 791  ALTQRLELLELDHEQTR-----RGRAKAAPKTKPAT 821
                R    EL+ EQ R     +G  K+  + K  T
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRIKELT 1853



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 51/250 (20%), Positives = 112/250 (44%), Gaps = 13/250 (5%)

Query: 14   VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
            +++A+ E LRA V++         +E I+ +E    +  +   L  Q +++E D   ++S
Sbjct: 1682 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741

Query: 74   EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
            E+E+  +    A    KK   D     E L +E  +   +  R    ++  +K L++ L 
Sbjct: 1742 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLD 1800

Query: 134  NTQS-----ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
              +        ++L  +   ++E+   +E ++ R  + +K  +  E R+ +   + EE+ 
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDK 1860

Query: 189  ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
             +L +   ++ + Q++ +  K + +  EE+    N+ L    ++    + +L+EA E   
Sbjct: 1861 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA---NTNLSKFRKV----QHELDEAEERAD 1913

Query: 249  TEREQKNSLR 258
                Q N LR
Sbjct: 1914 IAESQVNKLR 1923



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 58/256 (22%), Positives = 119/256 (46%), Gaps = 35/256 (13%)

Query: 12   RLVMEAQPEW--LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYE 69
            R+  EAQ +   L++ +K    +L +  R      E  +A++E ++ L      L+ + E
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNL------LQAELE 1688

Query: 70   AIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLR 129
             +R+ +EQ + +        +K+A      E+ LI E++ + Q    +   L  + K++ 
Sbjct: 1689 ELRAVVEQTERS--------RKLA------EQELI-ETSERVQLLHSQNTSLINQKKKME 1733

Query: 130  NVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENI 189
            + LT  QSE E      +  +E  +        + +++K+ +   A L +    +E+   
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793

Query: 190  SLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE-------DAIRLKEISERQLEE 242
             LQ ++      Q+  +G K ++++LE     L  +LE       ++++    SER+++E
Sbjct: 1794 DLQHRLD--EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851

Query: 243  ALETLKTEREQKNSLR 258
               T +TE ++KN LR
Sbjct: 1852 L--TYQTEEDKKNLLR 1865


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 150/752 (19%), Positives = 302/752 (40%), Gaps = 100/752 (13%)

Query: 119 LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQR--GRLRDDIKEYKFREAR 176
           L++  ++ QL  V+    ++N+   S  Q LK+ ++  EIQ+     R+ I +YK +   
Sbjct: 42  LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE-EIQQILAETREKILQYKSKVTE 100

Query: 177 LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE---------------EETEY 221
            L    +++    SL+  + + +Q   EFE  KH ++ ++                E E 
Sbjct: 101 ELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEE 160

Query: 222 LNSQLEDAIR----LKEISERQLEEALETLKT--EREQKNSLRKELSHYMSINDSFYTSH 275
           +  + E+ +R    L+   E+    ALE L+    RE +  L+ +  H  S+N     + 
Sbjct: 161 IRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAE 220

Query: 276 LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLP--LDNKTSTPKKEGL-----APP 328
               ++    +    E   + + L+  +E G L K     + +  T K+  L        
Sbjct: 221 ELHRMEVESLNKMLEELRLERKKLIEDYE-GKLNKAQSFYERELDTLKRSQLFTAESLQA 279

Query: 329 SPSLVSDLLSELNISE------IQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE 382
           S    +DL  E    E      I KLK +L  ++ E   LL   Q  Q  L     ++  
Sbjct: 280 SKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQV 339

Query: 383 QQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVA 442
            Q+++    E   AL  L   KE ++ L   ++R   +  D          ++    H+ 
Sbjct: 340 LQKQLDDAKEGEMAL--LSKHKEVESELAAARERLQQQASD----------LVLKASHIG 387

Query: 443 VAEAGELREQ-----LKALRSTHEAREAQHAEEKGRYEAEGQALTEK-----VSLLEKAS 492
           + +A ++ ++     L++ +S    R +Q  EE+    ++ Q+L E+     + L +K +
Sbjct: 388 MLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVN 447

Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHV--CMCNNETPN 550
              R      E+ELK +     E    L+ A  + +   EELA  +H     + +N   +
Sbjct: 448 EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL---EELAWKHHMAIEAVHSNAIRD 504

Query: 551 RVMLDYYREGQGGAGRTS---PGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSP 607
           +  L    E Q    + +      +   E    +  +         E G        S  
Sbjct: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564

Query: 608 SPGSS--LPSPLSDPRREPMNIYNLIAIIRDQIKHLQ-AAVDRTTELSRQRIASQELGPA 664
             GS+  L + L D +     + N + + +D +K  + A ++   EL ++R   +E   A
Sbjct: 565 GLGSAEGLIASLQDSQER---LQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAA 621

Query: 665 VDKDKEALMEEILKLKSLLSTK--REQITTLRTVLKANKQTAEVALANLKSKYENEKAMV 722
           + ++++  ++++     +  T+  R++ + LR                L+ ++E +K   
Sbjct: 622 MKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE--------------ELRLQHEEDKKSA 667

Query: 723 TETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKT-LNSL 781
              +++L++  K    D+         +  + ++ + Q+  +++ L     + +T L  L
Sbjct: 668 MSQLLQLKDREKNAARDS---------WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQL 718

Query: 782 LRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
                Q++  LTQ LE LE  H+Q  +   +A
Sbjct: 719 QAQFTQERQRLTQELEELEEQHQQRHKSLKEA 750



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 118/580 (20%), Positives = 247/580 (42%), Gaps = 105/580 (18%)

Query: 5    SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAV-------LEEKHQL 57
            +++E Y R +   Q   L  EV +L+   ++T  E   A ++ +A+       + +K +L
Sbjct: 452  TQQEYYERELKNLQSR-LEEEVTQLNEAHSKTLEEL--AWKHHMAIEAVHSNAIRDKKKL 508

Query: 58   KLQFEE--------LEVDYEAIRSEMEQLKEAF-GQAHTNHKKV---------AADGESR 99
            ++  EE        LE D   ++ E+E LKE    + +T ++++         +  G   
Sbjct: 509  QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 568

Query: 100  EESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE--------NERLASVAQELK- 150
             E LI      ++    ++   +  LK+ ++ L N + E         E +A++ +E K 
Sbjct: 569  AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKL 628

Query: 151  -----------EINQNVEIQRGRLRDDIK---------------EYKFREARLLQDYSEL 184
                       +  +N+  +  +LR++++               + K RE    +D  + 
Sbjct: 629  KVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 688

Query: 185  EEENISLQKQVSVLRQN-QVEFEGLKHEIKRLE----EETEYLNSQLEDAIRLKEISERQ 239
            + E+  L  Q+S+L+QN +++    +  +++L+    +E + L  +LE+     +   + 
Sbjct: 689  KVED--LLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 746

Query: 240  LEEA-LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEA 298
            L+EA +   +T  E+K   ++ L +++    S   + L    D  + S +      + E 
Sbjct: 747  LKEAHVLAFQTMEEEKEKEQRALENHLQQKHS---AELQSLKDAHRESMEGFRIEMEQEL 803

Query: 299  LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM--- 355
                FE     K  L +  S    +  A        DLL   +  E+   K +L +    
Sbjct: 804  QTLRFELEDEGKAMLASLRSELNHQHAA------AIDLLRHNHHQELAAAKMELERSIDI 857

Query: 356  -EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-----------RLQAS 403
              R+    +  + D Q++L H    +SE  ++V  L EN+SAL            R+++ 
Sbjct: 858  SRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE 917

Query: 404  KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLK----ALRST 459
              +Q  L +E+D +   +    E+D+   + L  K ++  A+  +  E LK    AL+ +
Sbjct: 918  SNQQIRL-HEQDLNKRLE---KELDVMTADHLREK-NIMRADFNKTNELLKEINAALQVS 972

Query: 460  HEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELL 499
             E  E ++   + + E + Q +TE  ++L +  +  ++L+
Sbjct: 973  LEEMEEKYLMRESKPE-DIQMITELKAMLTERDQIIKKLI 1011


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.330 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,632,354
Number of Sequences: 37866
Number of extensions: 1368483
Number of successful extensions: 17171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 316
Number of HSP's successfully gapped in prelim test: 1053
Number of HSP's that attempted gapping in prelim test: 8153
Number of HSP's gapped (non-prelim): 5693
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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