Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21735417
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
(824 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens] 1582 0.0
gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens] 1580 0.0
gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens] 973 0.0
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens] 973 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 109 9e-24
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 102 1e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 96 2e-19
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 96 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 96 2e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 96 2e-19
gi|71061468 centromere protein E [Homo sapiens] 90 1e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 89 1e-17
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 89 2e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 1e-16
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 85 2e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 83 9e-16
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 83 9e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 83 1e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 83 1e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 81 5e-15
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 80 6e-15
gi|38044112 restin isoform b [Homo sapiens] 80 8e-15
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 80 8e-15
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 80 8e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 80 8e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 80 1e-14
gi|4506751 restin isoform a [Homo sapiens] 80 1e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 79 1e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens] 78 3e-14
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 78 4e-14
>gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
Length = 824
Score = 1582 bits (4095), Expect = 0.0
Identities = 824/824 (100%), Positives = 824/824 (100%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
Sbjct: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
Sbjct: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
Sbjct: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
Sbjct: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
Sbjct: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
Sbjct: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
Sbjct: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
Sbjct: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
Sbjct: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
Query: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
Sbjct: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
Sbjct: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
>gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]
Length = 855
Score = 1580 bits (4092), Expect = 0.0
Identities = 823/824 (99%), Positives = 824/824 (100%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ
Sbjct: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE
Sbjct: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD
Sbjct: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
Sbjct: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV
Sbjct: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA
Sbjct: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE
Sbjct: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA
Sbjct: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH
Sbjct: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHH 540
Query: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG
Sbjct: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE
Sbjct: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPS+
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSV 824
>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
Length = 835
Score = 973 bits (2516), Expect = 0.0
Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)
Query: 23 RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
+ E++RL+ EL ETT EKIQAAEYGL VLEEK LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 14 KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
Query: 83 GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 74 GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
+V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
Query: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262
VE+EGLKHEIKR EEET LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253
Query: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322
Y+S+ND +H+ +S+DGLKF++D +EPNND + +NG HG L KL D +T T +K
Sbjct: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307
Query: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
E L P VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
Query: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
EQ E+V RLTE+++A+R LQ+SKE + LD EK RDS E+ YEVDING EIL CKY V
Sbjct: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422
Query: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501
AV E +L+ ++KAL+ + + +EK +YE++ Q E+V+ LEK +++ E +A
Sbjct: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482
Query: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561
+EKEL+K++ +A E +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542
Query: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616
T G P + RG SP L +G+ +P R + S PSP
Sbjct: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598
Query: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658
Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
LLRMAIQQKLALTQRLE LE DHEQ+RR + K K+K +P +
Sbjct: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKI 821
>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
Length = 975
Score = 973 bits (2515), Expect = 0.0
Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)
Query: 23 RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
+ E++RL+ EL ETT EKIQAAEYGL VLEEK LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 14 KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
Query: 83 GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 74 GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
+V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
Query: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262
VE+EGLKHEIKR EEET LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253
Query: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322
Y+S+ND +H+ +S+DGLKF++D +EPNND + +NG HG L KL D +T T +K
Sbjct: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307
Query: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
E L P VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
Query: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
EQ E+V RLTE+++A+R LQ+SKE + LD EK RDS E+ YEVDING EIL CKY V
Sbjct: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422
Query: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501
AV E +L+ ++KAL+ + + +EK +YE++ Q E+V+ LEK +++ E +A
Sbjct: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482
Query: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561
+EKEL+K++ +A E +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542
Query: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616
T G P + RG SP L +G+ +P R + S PSP
Sbjct: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598
Query: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660
SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658
Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
Query: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780
MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
Query: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824
LLRMAIQQKLALTQRLE LE DHEQ+RR + K K+K +P +
Sbjct: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKV 821
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 109 bits (273), Expect = 9e-24
Identities = 182/826 (22%), Positives = 358/826 (43%), Gaps = 112/826 (13%)
Query: 57 LKLQFEELEVDYEAIRSEMEQ----LKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
LKL+ +EL+ + E+++S+M+Q L+ QA H K + + + ++L +E E+
Sbjct: 2099 LKLK-KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157
Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
+ L + K+++ + N S +LA+ + + + + R R+ D+ K+++
Sbjct: 2158 TIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD----RDRVIDEAKKWER 2213
Query: 173 REARLLQDYSE---LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDA 229
+ + +Q E L+E+N S+ K LRQ + E LK I RLE + + S+ +
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQ--LRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 230 IRLKEISERQLEEALETLKTEREQKNSLRKELSH--YMSIND-SFYTSHLHVSLDGLKFS 286
++L+ ++ +TL+ E ++ S +E H + S N+ + S L D L
Sbjct: 2272 VQLQ-------QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
Query: 287 DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ 346
++ E + + + G A + ++K S + E S L S L E+N+ E Q
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQ-NSKFSYEQLETDLQASRELTSRLHEEINMKE-Q 2382
Query: 347 KLKQQLMQMEREKAGLLATL-QDTQKQLEHTRGSLSEQQE--------------KVTRLT 391
K+ L E +A L Q K+++ LS+++E K +L
Sbjct: 2383 KIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
Query: 392 ENLSALRRLQASKERQ--------TALDNEKDRDSHEDGDYYEVDINGPEILACKYHV-- 441
E L +++ ++ Q ++L N++DR GDY +++ I+ K +
Sbjct: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV---GDYQQLEERHLSIILEKDQLIQ 2499
Query: 442 -AVAEAGELREQLKALRSTHEAREAQHAE---EKGRYEAE-GQALTEKVS----LLEKAS 492
A AE +L+E+++ LRS + +++A+ E +Y + Q +T K S LLE
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQL 2559
Query: 493 RQDREL---LARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETP 549
+Q++EL A+LE++LK+ + + + S + Q+E S+E+ +L + +
Sbjct: 2560 QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
Query: 550 NRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSP 609
+ +G G + E R S + E +
Sbjct: 2620 -------ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK 2672
Query: 610 GSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDK 669
+ L ++E ++++ I+R++ + A +R EL+R + ++ V K+
Sbjct: 2673 VGEIEDKL---KKELKHLHHDAGIMRNE---TETAEERVAELARDLVEMEQKLLMVTKEN 2726
Query: 670 EALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYE---NEKAMVTETM 726
+ L +I +S+ L+ ++ A L LK KY+ E A + E
Sbjct: 2727 KGLTAQIQSFGRSMSS-----------LQNSRDHANEELDELKRKYDASLKELAQLKEQG 2775
Query: 727 MKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAI 786
+ R L E A + +S + ++ L+++ +QL + +++ L+S L +
Sbjct: 2776 LLNRERDALLSETAFSMNSTE-------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY 2828
Query: 787 QQKLALTQRLELL--ELDH-----EQTRRG-----RAKAAPKTKPA 820
Q + ++ + L E DH E+ R+ R+ A P T PA
Sbjct: 2829 NQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874
Score = 80.1 bits (196), Expect = 8e-15
Identities = 185/848 (21%), Positives = 331/848 (39%), Gaps = 124/848 (14%)
Query: 23 RAEVKRLSHELAE-----TTREKIQAAEYG-LAVL-EEKHQLKLQFEELEVDYEAIRSEM 75
R ++RL+ LA+ + + K + G LA+L EE+ +L + + ++ +++ S
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569
Query: 76 EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
E LK A + +K+ + ES + S I ES ++ K ELQ E + L N
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE----KHKELQKEYEILLQSYENV 1625
Query: 136 QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
+E ER+ V + +++ Q + G+LR K E +L + E+EE ++K
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELY---GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 196 SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKN 255
+Q +E E E RL E ++ + S ++E LE +K E E
Sbjct: 1683 KSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE--- 1736
Query: 256 SLRKELSHYMSINDSFY--TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLA---- 309
+L K+ MS DS L ++G E + N E G +
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 310 -----KLPLDNK-TSTPKKEGLAPPSPSLVSDLLS--ELN--ISEIQKLKQQLMQMEREK 359
L + + T + +P++ D S E+N + +I +LK+++ +E EK
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856
Query: 360 AG---LLATLQDTQK----QLEHTRGSLSEQQEKVTRLT-------ENLSALRRLQASKE 405
TL++ + Q+ G L QE+VT++ E LS + +L+ + E
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
Query: 406 RQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ----LKALRSTHE 461
EKD D E ++NG C+ EL E LK S E
Sbjct: 1917 E------EKD-DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 462 AREAQHAEEKGRYEAE-------------------------GQALTEK---VSLLEKASR 493
+ Q +EK + E+E + L EK V L+K
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 494 QDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPN-RV 552
+ +E ++ LE+ +K + V E+Q L + + E LA H E + +V
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITK-------ENLAQAVEHRKKAQAELASFKV 2082
Query: 553 MLDYYREGQGGAGRT-SPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGS 611
+LD + Q A R + + E + + + + R +
Sbjct: 2083 LLD---DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 612 SLPSPLSDPRREPMNIYNLIAIIR-------DQIKHLQAAVDRTTELSRQRIASQELGPA 664
++ L RRE +++ I I+ +++ LQ +D T Q A + +
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV---TQLAAFTKSMSS 2196
Query: 665 VDKDKEALMEEI----LKLKSLLSTKREQITTLR---TVLKANKQTAEVALANLK---SK 714
+ D++ +++E K + +K E+I +VLK + + + LK S+
Sbjct: 2197 LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256
Query: 715 YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
E++K + K + E++ ++ T ++ +E Q +LA E E
Sbjct: 2257 LEHDKQIWES---KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313
Query: 775 KKTLNSLL 782
K+L L
Sbjct: 2314 LKSLKDQL 2321
Score = 74.3 bits (181), Expect = 4e-13
Identities = 174/848 (20%), Positives = 333/848 (39%), Gaps = 122/848 (14%)
Query: 37 TREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADG 96
T + +Q E ++ E LK Q L EA + ++E+ E N+ +++ G
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970
Query: 97 ESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNV 156
+ +E L E ++ ++ +LQ L + +L E LA++ E K+
Sbjct: 971 QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030
Query: 157 EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE 216
E +RG + +D + ++ E + E+E LK I E
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIY--------------------LKQTISEKE 1070
Query: 217 EETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL 276
E +++ LE+ + +E + +++ +TL+ + Q + L+ E+S +I TS+
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
Query: 277 HVSLDG---------------LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
S DG S + +P + + L E L K + TS
Sbjct: 1131 DAS-DGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTS--- 1186
Query: 322 KEGLAPPSPSLVSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQL-EHTRG 378
++ + + L EL + +L++Q + +E + L+ Q Q+ E G
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246
Query: 379 SL--SEQQEKVTRLTENLSALRRLQASKERQTALDNE--KDRDSH-EDGDYYEVDINGPE 433
L ++QQE + L + Q L++ D SH ED + G
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ---GGTS 1303
Query: 434 ILACKYHVAVAEAGELREQLKALRSTHE----------------------------AREA 465
+ K + EA ++ +LK +T E + EA
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 466 QHAEEKGRYEAEGQAL----TEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLS 521
+ E + + E L E + L+ + ++L+++ E+++ +S E + +L+
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
Query: 522 VAQDELVTFSEELANLYHHVCMCNNETPNR-----VMLDYYREGQGGAGRTSPG----GR 572
Q E++ + + L+ + M E R V L ++ G S R
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 573 TSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIA 632
A R L L E A GT + + + S +S +E + +A
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLA-RGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 633 IIRDQIKHLQAAVDRTTELSRQRIAS--QELGPAVD---KDKEALMEEILKLKSLLSTKR 687
+++++ L +DR+ L Q ++S + L A++ +DKE L++EI +SL S+K
Sbjct: 1543 LLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDKEKLVKEI---ESLKSSKI 1598
Query: 688 EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR 747
+ T + K ++ E+ L + ++ NE + + +R E + L + LR
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYEN-VSNEAERIQHVVEAVRQEKQEL------YGKLR 1651
Query: 748 AMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTR 807
+ A + E ++QL AE E + + +R K A +++ ++LEL+ E R
Sbjct: 1652 STEANK--------KETEKQLQEAEQEMEEMKEKMR-----KFAKSKQQKILELEEENDR 1698
Query: 808 RGRAKAAP 815
RA+ P
Sbjct: 1699 L-RAEVHP 1705
Score = 72.8 bits (177), Expect = 1e-12
Identities = 159/812 (19%), Positives = 328/812 (40%), Gaps = 72/812 (8%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+E Q + +K+L EL E ++ + E A K Q++ + + + + E
Sbjct: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA----KQQIQRKLQAALISRKEALKE 1498
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTN 134
+ L+E A +++ E + ++ K+ R L LQ E +L +
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL-LQEERDKLITEMDR 1557
Query: 135 TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
+ EN+ L+S + LK + + + +L +KE + ++ + + +E +E++ LQK+
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKL---VKEIESLKSSKIAESTEWQEKHKELQKE 1614
Query: 195 VSVLRQN----QVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE 250
+L Q+ E E ++H ++ + +E + L +L K+ +E+QL+EA + ++
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
Query: 251 REQKNSLRK-ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLA 309
+E+ K + + + + V G D A+ + N L
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAG-----DTAKECMETLLSSNASMKEELE 1729
Query: 310 KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDT 369
++ ++ +T + K + L D LSE E+Q LK Q+ ++A L AT +
Sbjct: 1730 RVKMEYETLSKKFQSLMSE-----KDSLSE----EVQDLKHQIEGNVSKQANLEATEKHD 1780
Query: 370 QKQLEHTRGSLS-----EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
+ G+ S E+Q+ ++ T + + ++K A+ KD SH++ +
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRP-TCSESVPSAKSANPAV--SKDFSSHDEINN 1837
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEK 484
Y I+ + +A E +++ K T E + + + E + L E+
Sbjct: 1838 YLQQID-------QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE 1890
Query: 485 VSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC-- 542
V+ + ++Q +E L+R + K+ + A E + L ++ L+ EL + C
Sbjct: 1891 VTKMNLLNQQIQEELSR----VTKLKETAEEEKDDL---EERLMNQLAELNGSIGNYCQD 1943
Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
+ + + N ++ + + + + + + + + L + + + G
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPG- 2002
Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVD-----RTTELSRQRIA 657
+ S L L + ++E + +++I L+ V +T I
Sbjct: 2003 ---NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
Query: 658 SQELGPAVDKDKEALMEEILKLKSLL-STKREQITTLRTVLKANKQ---TAEVALANLKS 713
+ L AV+ K+A E+ K LL T+ E L LK K+ E + +K
Sbjct: 2060 KENLAQAVEHRKKA-QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Query: 714 KYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED 773
K E+ + + + E K LKE L A+ + T + E+Q L +
Sbjct: 2119 KDEDLERRLEQA------EEKHLKEKKNMQEKLDALRREKVHLEET-IGEIQVTLNKKDK 2171
Query: 774 EKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
E + L L + Q A T+ + L+ D ++
Sbjct: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR 2203
Score = 70.1 bits (170), Expect = 8e-12
Identities = 108/543 (19%), Positives = 225/543 (41%), Gaps = 74/543 (13%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
+S S +EE ++ + + E+K L + L++ E I E +++ +QL
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMET 2444
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
+ ++ + +++++ ++ + ++ D + EE + K+Q E
Sbjct: 2445 LKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAE 2504
Query: 121 ---LQTELKQLRNVLTNTQSENERL-ASVAQELKEINQNVEIQRGRLRDDI-------KE 169
L+ E++ LR+ + + SEN +L A + Q +++NQ + I+ + + + KE
Sbjct: 2505 NNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564
Query: 170 YKFREARLLQDYSELEEENISLQKQVSVLRQNQ----VEFEGLKHEIKRL---------- 215
+ + A+L + E EE N L++ + L++ + E E LK I +L
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
Query: 216 -------------EEETEYLNSQLEDA-IRLKEISERQLEEALETLKTEREQKNSLRKEL 261
EEE L++ + R+ E+ E + E K E ++ L+KEL
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL 2684
Query: 262 SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
HLH ++ + AE A L + +NK T +
Sbjct: 2685 ------------KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQ 2732
Query: 322 KEGLAPPSPSL------VSDLLSEL------NISEIQKLKQQLMQMEREKAGLL------ 363
+ SL ++ L EL ++ E+ +LK+Q + + RE+ LL
Sbjct: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL-LNRERDALLSETAFS 2791
Query: 364 --ATLQDTQKQLEHTRGSLSEQQEKVTRLTENL-SALRRLQASKERQTALDNEKDRDSHE 420
+T +++ LE L + E++ L+ L + ++Q+ + +L NE+D +E
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
+ + + G + A + + AE L++ + +L++ + + + +Y Q
Sbjct: 2852 LEKFRKSE-EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2910
Query: 481 LTE 483
+TE
Sbjct: 2911 ITE 2913
Score = 66.6 bits (161), Expect = 9e-11
Identities = 130/637 (20%), Positives = 242/637 (37%), Gaps = 120/637 (18%)
Query: 5 SEEEEYARLVMEAQPEW--LRAEVKRLSHELAETTR--EKIQAAEYGLAVLEEKHQLKLQ 60
S+ EE L +Q E L +E+K L +L + + EK + + L + + + +Q
Sbjct: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350
Query: 61 -----FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYV 115
+E+LE D +A R +L E +E+ +I + KE+
Sbjct: 2351 NSKFSYEQLETDLQASRELTSRLHEEINM--------------KEQKIISLLSGKEEAIQ 2396
Query: 116 RKVLELQTELKQLRNVLTNTQSENERLASVAQE---------------LKEINQNVEIQR 160
+ EL+ + + L N S+ E V +E LK I + Q+
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456
Query: 161 GRLRDDIKEYKFRE---ARLLQDYSELEEENIS-LQKQVSVLRQNQVEFEGLKHEIKRLE 216
+L +K + R++ DY +LEE ++S + ++ ++++ E LK EI+ L
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLR 2516
Query: 217 EETEYLNSQ--------------LEDAIRLKEISERQLEEALETLKTEREQKNS-LRKEL 261
+ LNS+ L I +K+ ++QL E E E K + L ++L
Sbjct: 2517 SHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKL 2576
Query: 262 SHYMSINDSFYTS---------HLHVSLDGLKFSDDAAEPNNDA--EALVNGFEHGGLAK 310
N+ S L ++ LK S A E G H L
Sbjct: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636
Query: 311 LPLDNKTSTPKKEGLAPPSPSLVSDLLSEL---------NISEIQ-KLKQQLMQMEREKA 360
+ + L S +++L EL + EI+ KLK++L + +
Sbjct: 2637 ----KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692
Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLT-ENLSALRRLQASKERQTALDNEKDRDSH 419
+ + ++++ L E ++K+ +T EN ++Q+ ++L N +D +
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752
Query: 420 EDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQ 479
E + L KY ++ E +L+EQ G E
Sbjct: 2753 ELDE-----------LKRKYDASLKELAQLKEQ-------------------GLLNRERD 2782
Query: 480 A-LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
A L+E + L +L ++L + L + +++ +FS+ +A+L
Sbjct: 2783 ALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842
Query: 539 HHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSP 575
+ NE L+ +R+ + G R++ TSP
Sbjct: 2843 NERDHLWNE------LEKFRKSEEGKQRSAAQPSTSP 2873
Score = 66.2 bits (160), Expect = 1e-10
Identities = 173/875 (19%), Positives = 339/875 (38%), Gaps = 122/875 (13%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
++ E+E+ + + EA R + + + E RE+++ + ++ ++L+ Q
Sbjct: 1167 LALEKEKEQLQKKLQEALTS--RKAILKKAQEKERHLREELKQQK------DDYNRLQEQ 1218
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQA------HTNHKKVAADGESREESLIQESASKEQYY 114
F+E + E I ++ QL+ ++ T+ ++ + EE L + + EQ++
Sbjct: 1219 FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT---EQHH 1275
Query: 115 VRKVLELQ------------------TELKQLRNVLTNTQSENERL----ASVAQELKEI 152
+ VLE T + Q++ L ++E L +S EL +
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 153 NQNV-----EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ-KQVSVLRQNQVEFE 206
++ V +I + L + + EA + + + + E+ LQ + LR+ Q + +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 207 GLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMS 266
L+ I + EE+ YL+ QL + E AL ++TE ++ L K L +
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEK-----------EAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 267 INDSFY---TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE 323
+ + L V L +K + + A+ + L K + +E
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 324 GLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK---AGLLATLQDTQKQL--EHTRG 378
L SL + L S + ++ Q+ +EK G LA LQ+ + +L E R
Sbjct: 1505 EL-----SLARGTIERLTKS-LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558
Query: 379 -----SLSEQQEKVTRLTENLS-----ALRRLQASKERQTALDNEKDRDSHEDGDYYEVD 428
SLS E + E L+ ++ +++ K + A E E YE+
Sbjct: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618
Query: 429 INGPEILACK----YHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEK 484
+ E ++ + HV A E +E LRST EA + + ++ E E + + EK
Sbjct: 1619 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST-EANKKETEKQLQEAEQEMEEMKEK 1677
Query: 485 VSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSL-----SVAQD-ELVTFSEEL 534
+ K+ +Q E RL E+ D A E +L S+ ++ E V E
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 535 ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTS-------PGGRTSPEARGRRSPILLP 587
+ M ++ + + D + +G + + +T+ G +S
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS----- 1792
Query: 588 KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDR 647
+ E D + + P+ S+PS S ++ I + ++ + +R
Sbjct: 1793 ---IPGETEEQDSLSMSTRPTCSESVPSAKS-ANPAVSKDFSSHDEINNYLQQIDQLKER 1848
Query: 648 TTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVA 707
L ++ ++E ++ +K L+ +I L +E++T + +L Q
Sbjct: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM-NLLNQQIQEELSR 1907
Query: 708 LANLKSKYENEKAMVTETMMKLRNELKAL-------KEDAATFSSLRAMFATRCDEYITQ 760
+ LK E EK + E +M EL DA + L + +++
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE 1967
Query: 761 LDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
L+E ++QL EK + S +R +K+ Q+
Sbjct: 1968 LEEEKQQLV---KEKTKVESEIRKEYLEKIQGAQK 1999
Score = 64.7 bits (156), Expect = 3e-10
Identities = 154/833 (18%), Positives = 302/833 (36%), Gaps = 132/833 (15%)
Query: 13 LVMEAQPEWLRAEVKRLSHELAETTREKIQAA-EYGLAVLEEKHQLKLQFEELEVDYEAI 71
L +E + + LRAEV H +T +E ++ ++ EE ++K+++E L ++++
Sbjct: 1690 LELEEENDRLRAEV----HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 72 RSEMEQLKEAFG-------------------QAHTNHKKVAADGESREESLIQESASKEQ 112
SE + L E + H N V +G +E S
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
E K ++ S ++ + + Q++ ++ + + ++E K
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA--------GLEEEKQ 1857
Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
+ Q LE E +L Q+S E + L+ E+ ++ + + +L +L
Sbjct: 1858 KNKEFSQT---LENEKNTLLSQIST---KDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
Query: 233 KEISERQLEEALETLKTEREQKNSLRKELSHY-MSINDSFYTSHLHVS-LDGLKFSDDAA 290
KE +E + ++ E L + + N + +Y + D+ + L S + LK
Sbjct: 1912 KETAEEEKDDLEERLMNQLAELNG---SIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968
Query: 291 EPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN--ISEIQK- 347
E + K L+ K+ G + L +LL E + ++QK
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL-QELLKEKQQEVKQLQKD 2027
Query: 348 ---LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE---------------------- 382
++++ +ER L ++QK LE T+ +L++
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
Query: 383 QQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVA 442
Q E L +NL + LQ++KE + +KD D + E
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE-------------EKH 2134
Query: 443 VAEAGELREQLKALRSTHEAREAQHAEEK--------GRYEAEGQALTEKV--------- 485
+ E ++E+L ALR RE H EE + + E Q L E +
Sbjct: 2135 LKEKKNMQEKLDALR-----REKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 486 ---SLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
S+ +DR ++ +K +K SD + + + +D ++L + H+
Sbjct: 2190 FTKSMSSLQDDRDR-VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM- 2247
Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSP--GGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
N L++ ++ +T + +G +L
Sbjct: 2248 --EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL--------SQLEETR 2297
Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQ 659
SS + + L S L + + ++ N + ++Q +L+ + + ++ + + +
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE 2357
Query: 660 ELGPAVDKDKE---ALMEEI----LKLKSLLSTKREQITTLRTVLKANKQTAEVALANLK 712
+L + +E L EEI K+ SLLS K E I L+ L NL
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417
Query: 713 SKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQ 765
S+ E E ++ E K ++ L E T + D ++ + +Q
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470
Score = 62.8 bits (151), Expect = 1e-09
Identities = 126/586 (21%), Positives = 221/586 (37%), Gaps = 110/586 (18%)
Query: 7 EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-----LKLQF 61
EEE A L E++ E +E +R E+ E K EY + K Q LK
Sbjct: 1013 EEELANLKDESKKEIPLSETER--GEVEEDKENK----EYSEKCVTSKCQEIEIYLKQTI 1066
Query: 62 EELEVDYEAIRSEMEQ---LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV 118
E EV+ + IR ++E+ +E F QA ++ + L+Q S+ Q ++K+
Sbjct: 1067 SEKEVELQHIRKDLEEKLAAEEQF-QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL 1125
Query: 119 LELQTELK---------------------------QLRNVLTNTQSENERLASVAQEL-- 149
+ T+ +L + + E E+L QE
Sbjct: 1126 ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
Query: 150 --KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEG 207
K I + + + LR+++K+ K RL + + E +EN ++ Q LRQ Q+
Sbjct: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ---LRQLQI---- 1238
Query: 208 LKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSI 267
Q+ ++I K S Q E T E + E H +
Sbjct: 1239 -----------------QVRESIDGKLPSTDQQESCSSTPGLEEPLFKA--TEQHHTQPV 1279
Query: 268 NDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAP 327
+S D + DA AL G +A++ K +K L
Sbjct: 1280 LES-------------NLCPDWPSHSEDASALQGG---TSVAQIKAQLKEIEAEKVEL-- 1321
Query: 328 PSPSLVSDLLSELNISEIQKLKQQLMQMERE--KAGL-LATLQDTQKQLEHTRGSLSEQQ 384
+L SE+ K +++ Q++ + K GL + +L+ + E SL ++
Sbjct: 1322 -------ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
Query: 385 EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
E L LR LQ + L ++K+ ED Y ++ E K +
Sbjct: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKE----EDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
E +L +KAL + E + +H E + + E + +K + + SR +++ +L+
Sbjct: 1431 EQEDL---IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 505 ELKKVSDVAGET---QGSLSVAQDELVTFSEELANLYHHVCMCNNE 547
L + E Q LS+A+ + ++ LA++ V N E
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
Score = 56.6 bits (135), Expect = 9e-08
Identities = 109/558 (19%), Positives = 220/558 (39%), Gaps = 84/558 (15%)
Query: 4 PSEEEEYARLVMEAQPEWLRAEVKRLSHEL-----------AETTREKIQAAEYGLAVLE 52
P EE+ ++ + E + E++++ H+L A+ T+ + + +E
Sbjct: 126 PQSEEQLSKHDKSSTEEEM--EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183
Query: 53 EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
E +K Q +E E +++++ Q QA ++V + ++R E+ ++ +
Sbjct: 184 EFVMMKQQLQEKEEFISTLQAQLSQT-----QAEQAAQQVVREKDARFETQVRLHEDELL 238
Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
V + +++TE++Q VL E+E + L Q V++
Sbjct: 239 QLVTQA-DVETEMQQKLRVLQRKLEEHE------ESLVGRAQVVDL-------------- 277
Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
L Q+ + E+ N L +Q L+Q + E L++ ++ EE++ L ++E +
Sbjct: 278 ----LQQELTAAEQRNQILSQQ---LQQMEAEHNTLRNTVETEREESKILLEKMELEVAE 330
Query: 233 KEISERQLEEALETLKTEREQKNSLRKEL-SHYMSINDSF------YTSH---------- 275
+++S L+E + L + EQ + EL S Y ++ TSH
Sbjct: 331 RKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 276 LHVSLDGLK---------FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLA 326
L + D LK ++ A + + L + + N+ + E +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS 450
Query: 327 PPS-PSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
S P + ++ + I L+++++++E EK LL + +LE + +
Sbjct: 451 QTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL----SSIELEELKAENEKLSS 506
Query: 386 KVTRL-TENLSALRRLQASKERQTALDNEKDRDSHEDG-DYYEVDINGP----EILACKY 439
++T L +N + + S+ + N++ + E G D E + +L +
Sbjct: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566
Query: 440 HVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELL 499
A E L+ QL+ R+ E +E + E EG A + LE QD L+
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTG-QDFPLM 625
Query: 500 ARLEKELKKVSDVAGETQ 517
E L V T+
Sbjct: 626 PNEESSLPAVEKEQASTE 643
Score = 55.5 bits (132), Expect = 2e-07
Identities = 88/395 (22%), Positives = 167/395 (42%), Gaps = 58/395 (14%)
Query: 25 EVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQ 84
++ LS +L E + ++Q+ +A L+ + + L + E R E + + Q
Sbjct: 2816 QLLHLSSQL-EDSYNQVQSFSKAMASLQNER------DHLWNELEKFRKSEEGKQRSAAQ 2868
Query: 85 AHTNH------KKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
T+ KK + ++ + L++E + +Q Y++ E+ TEL L+ L Q +
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDK 2927
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY----SELEEENISLQKQ 194
+ + +EL++ N + + + +LR + ++ E R+ + Y S+ +++ LQ
Sbjct: 2928 TKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNL 2987
Query: 195 VSVLRQNQVEFEGLKHEIKR---------------LEEETEYLNSQLEDAIRLKEISERQ 239
+ LR + + + LK + +R L ETE L +QL D+++ E +
Sbjct: 2988 IRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047
Query: 240 LEEALETLKTEREQKNSLRKEL---SHYMSINDSFYTSHL-HVSLDGLKFSDDAAEPNND 295
+++ E+KN+L +L S + N Y L H ++ + + A P N
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
Query: 296 AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
A E G+ ++ S P E L P S SE Q QQL
Sbjct: 3108 DVAPGAPQEKNGV------HRKSDP--EELREPQQS----------FSEAQ---QQLCNT 3146
Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
+E L L++ + Q +LS +E++ RL
Sbjct: 3147 RQEVNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181
Score = 46.6 bits (109), Expect = 9e-05
Identities = 168/840 (20%), Positives = 319/840 (37%), Gaps = 129/840 (15%)
Query: 37 TREKIQAAEYGLAVLE-EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAAD 95
T E I + + + LE EK L L ELE +++E E+L ++ AD
Sbjct: 466 TEENIASLQKRVVELENEKGALLLSSIELE----ELKAENEKLSSQITLLEAQNRTGEAD 521
Query: 96 GESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQ-ELKEINQ 154
E E S++ + A+K + + ++VL NT S+ + SV E+KE +
Sbjct: 522 REVSEISIV-DIANKRS---------SSAEESGQDVLENTFSQKHKELSVLLLEMKEAQE 571
Query: 155 NVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE--- 211
+ + +L+ E E ++ ++E E I+ K L +F + +E
Sbjct: 572 EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Query: 212 ---IKRLEEETEYLNSQLEDAIRL----------KEISERQL----------EEALETLK 248
+++ + TE+ S+ + I L K+ ++ L ++ LE LK
Sbjct: 632 LPAVEKEQASTEH-QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK 690
Query: 249 TE---------------REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN 293
++ + + KE+S+ + + F + + S S++ +
Sbjct: 691 SQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLL 750
Query: 294 NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE----LNISEIQK-L 348
+ + L E K N ++ L S + +LL+E L+I K +
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810
Query: 349 KQQLMQMEREKAGLLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS 403
K +++Q E + L + Q T Q QL++ + E E+V ++ + L + +
Sbjct: 811 KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 404 KERQ-TALDN---EKDRD--------SHEDGDYYEVDINGPEILAC----KYHVAVAEAG 447
KE + T +D EK RD +D E+ + E + K+ + V E
Sbjct: 871 KELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV-EIK 929
Query: 448 ELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELK 507
L+EQL L EA++ Q E+ L + + A + +E L LK
Sbjct: 930 TLKEQLNLLSRAEEAKKEQVEED----NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985
Query: 508 KVSDVAGETQGSLSVAQDELV----TFSEELANLYHHVCMCNNETPNRVMLDYYREGQGG 563
K ++ + + + EL+ EELANL +E+ + L G+
Sbjct: 986 KENEQRKRKLQAALINRKELLQRVSRLEEELANL-------KDESKKEIPLSETERGEVE 1038
Query: 564 AGRTSPG-GRTSPEARGRRSPILLPKGLLAPEAG----RADGGTGDSSPSPGSSLPSPLS 618
+ + ++ + I L + + E R D ++ +L ++
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098
Query: 619 DPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILK 678
++ N QI LQA + + ++ I S A D D AL++E +
Sbjct: 1099 QTLQDKTN----------QIDLLQAEISENQAIIQKLITSNT--DASDGDSVALVKETVV 1146
Query: 679 LKSLLSTKREQ-ITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALK 737
+ + E L + A ++ E L+ + KA++ + K R+ + LK
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206
Query: 738 EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE 797
+ ++ L+ F DE ++ D+ + L +R +I KL T + E
Sbjct: 1207 QQKDDYNRLQEQF-----------DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Score = 40.8 bits (94), Expect = 0.005
Identities = 83/439 (18%), Positives = 168/439 (38%), Gaps = 64/439 (14%)
Query: 186 EENISLQKQVSVLRQNQVEFEGLKHE-IKRLEEETEYLNSQLEDAIRLKEISERQLEEAL 244
++N+ + +++ +EF E ++ E L +L+D IR K++ +Q +EAL
Sbjct: 23 DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82
Query: 245 ETLKTEREQK------------NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEP 292
+ + + K SL K + + + + K + E
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
Query: 293 NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKL 348
+ E + + + L + + + E A S + ++ + + E I L
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 349 KQQLMQMEREKAG-----------------------LLATLQDT----QKQLEHTRGSLS 381
+ QL Q + E+A L T D Q++L + L
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262
Query: 382 EQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDG---DYYEVDINGPEILAC 437
E +E + + + L++ L A+++R L + + E + E + +IL
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE 322
Query: 438 KYHVAVAEA----GELREQLKALRSTHEAREAQHAEEKGRYEAEGQ----ALTEKVSLLE 489
K + VAE L+E++ L E AE + RY A Q + EK S +
Sbjct: 323 KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHIL 382
Query: 490 KASRQDRELLARLE-------KELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
+ +EL + + K L+ ++ A ++ ++ +D+L S+E++ + +
Sbjct: 383 SLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442
Query: 543 MCNNETPNRVML-DYYREG 560
+ +ET ++ D Y EG
Sbjct: 443 LQQHETASQTSFPDVYNEG 461
Score = 30.4 bits (67), Expect = 7.0
Identities = 33/166 (19%), Positives = 71/166 (42%), Gaps = 8/166 (4%)
Query: 634 IRDQIKHLQAAVDRTTELSRQR-IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
+++++ + + V ++ RQ+ + Q+ A+ ++++A +I KLK K +
Sbjct: 50 VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK 109
Query: 693 LRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMF-- 750
+KA T + + TE M++ L+E S+L+A
Sbjct: 110 YIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169
Query: 751 --ATRCDEYITQLDE---MQRQLAAAEDEKKTLNSLLRMAIQQKLA 791
A + + T+++E M++QL E+ TL + L ++ A
Sbjct: 170 AQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 102 bits (255), Expect = 1e-21
Identities = 196/836 (23%), Positives = 332/836 (39%), Gaps = 127/836 (15%)
Query: 7 EEEYARL------VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
EE+ RL M+A + R EV+RL +REK A ++ +L+ +
Sbjct: 567 EEQLQRLRDKTDGAMQAHEDAQR-EVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE 625
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
E+L+ E +R + ++L+E A + +V + E R +++ K ++++E
Sbjct: 626 REKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE-RSHRQLEQLEGKRSVLAKELVE 684
Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR-------DDIKEYKFR 173
++ L + Q+E +A + + +E+ +LR D + +
Sbjct: 685 VREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSAL 744
Query: 174 EARLLQD-------YSELEEENISLQKQVSVLRQNQVEFEG--LKHEIKRLEE---ETEY 221
L QD ++LEEE +LQ RQ Q E E + E +RLEE E E
Sbjct: 745 NESLAQDKLDLNRLVAQLEEEKSALQG-----RQRQAEQEATVAREEQERLEELRLEQEV 799
Query: 222 LNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
LE ++R+ E ++ LE+ L TL+ ER Q +LS +S + +
Sbjct: 800 ARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859
Query: 282 GLKFSDDAAEPNNDAEALVNGFEHGGLA----KLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
++ + AA + EAL EH GLA + +T + + L +L L
Sbjct: 860 QVEALERAA---REKEALAK--EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914
Query: 338 SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL 397
++ +L+ + Q+E E LL + +L R + QEK + L + L A
Sbjct: 915 EVQR--QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKAS-LDKELMAQ 971
Query: 398 RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
+ +QA +E Q +L + R +HE+ D + + AE +L+ QL
Sbjct: 972 KLVQAEREAQASL--REQRAAHEE-DLQRLQ----REKEAAWRELEAERAQLQSQL---- 1020
Query: 458 STHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ 517
+ + E R EAE + L+E+++ L++ R + LLA EK Q
Sbjct: 1021 ------QREQEELLARLEAEKEELSEEIAALQQ-ERDEGLLLAESEK------------Q 1061
Query: 518 GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEA 577
+LS+ + E SE+L H + + E + R+ Q R++ TS E
Sbjct: 1062 QALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ---DRSTVNALTS-EL 1117
Query: 578 RGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQ 637
R R+ A E R D S L RE +R Q
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL--------REAEE-------LRTQ 1162
Query: 638 IKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVL 697
++ L+ A D L R+ + +Q + +E +E +L+ L ++ LR
Sbjct: 1163 LRLLEDARD---GLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALR--- 1216
Query: 698 KANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEY 757
++N++ L + K E+E+ +KL NE K ++ A R E
Sbjct: 1217 RSNEE-----LRSAVKKAESER-----ISLKLANEDK--EQKLALLEEARTAVGKEAGEL 1264
Query: 758 ITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
T L E++R A E + L ++M LD E TR GR A
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKM----------------LDSENTRLGRELA 1304
Score = 90.1 bits (222), Expect = 7e-18
Identities = 178/813 (21%), Positives = 316/813 (38%), Gaps = 130/813 (15%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQL---KLQFEELEVDYEAIRSEME 76
E + ++ + E + RE+ A E L L+ + + +L+ E ++ + R + E
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEE 1026
Query: 77 QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRNVLT 133
L + +++AA + R+E L+ + K+Q K E L +L R+ L
Sbjct: 1027 LLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLA 1086
Query: 134 NTQSENERLASVAQELKEINQN-VEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
E ER AQ +E +++ V LRD + + A Q+ L+E+ L
Sbjct: 1087 TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG 1146
Query: 193 KQV-SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
KQ S LR E E L+ +++ LE+ + L +L +A +R+L E+ E + +R
Sbjct: 1147 KQRDSCLR----EAEELRTQLRLLEDARDGLRRELLEA-------QRKLRESQEGREVQR 1195
Query: 252 EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKL 311
++ LR+ L ++ S+ + L+ + AE + L N + LA L
Sbjct: 1196 QEAGELRRSLGEGAKEREALRRSN-----EELRSAVKKAESERISLKLANEDKEQKLALL 1250
Query: 312 PLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQK 371
+ +T+ K+ G +L+ L ++ER + + ++
Sbjct: 1251 E-EARTAVGKEAG----------------------ELRTGLQEVERSRL-------EARR 1280
Query: 372 QLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDING 431
+L+ R + + TRL L+ L + + AL +++S
Sbjct: 1281 ELQELRRQMKMLDSENTRLGRELAEL-------QGRLALGERAEKESRR----------- 1322
Query: 432 PEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKA 491
E L + + EA L+ +R + + + E++G + + L +
Sbjct: 1323 -ETLGLRQRLLKGEAS-----LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGT 1376
Query: 492 SRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR 551
+Q + LE +L+ A E LS A+ ELA + V E
Sbjct: 1377 EKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARV--EVQRRAAEAQLG 1434
Query: 552 VMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL-LPKGLLAPEAGRADGGTGDSSPSPG 610
+ R G G SP R P + R +P +GL +P G+ SP P
Sbjct: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA 1494
Query: 611 SSLPSPLSDP-----------------RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSR 653
+S SP DP +RE + + + Q+ ++A D T +R
Sbjct: 1495 TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRAR 1554
Query: 654 QR----IASQELGPAVDKDKEALMEEI-LKLKSLLSTKREQITTLRTV--LKANKQTAEV 706
Q S+E +VD + E+ L+ +S+ ++RE+ TL V L+ + Q E
Sbjct: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
Query: 707 ALANLKSKYENEKAMVTETMMKLRNELKALKE--DAATFSSLRAMFATRCDEYITQ---- 760
L + K KA T KL + + LKE DA+ +++ R E Q
Sbjct: 1615 ELRASQEKISKMKANET----KLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRL 1670
Query: 761 ---------------LDEMQRQLAAAEDEKKTL 778
+D +QRQ+A +E + TL
Sbjct: 1671 GLSDREAQAQALQDRVDSLQRQVADSEVKAGTL 1703
Score = 79.3 bits (194), Expect = 1e-14
Identities = 177/754 (23%), Positives = 300/754 (39%), Gaps = 111/754 (14%)
Query: 94 ADGESREESLIQESASKEQYYVRKVL----ELQTELKQLRNVLTNTQSENERLASVAQEL 149
A +S +LI + K Q V+ + Q L LR L++++SE L Q L
Sbjct: 514 ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL 573
Query: 150 KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLK 209
++ + +++ + L ++ S L Q+Q LRQ + + + +
Sbjct: 574 RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQ 633
Query: 210 HEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSIND 269
E++R + + L + EDA++ R+LE + L+ +++ L KEL + + +
Sbjct: 634 EELRR---QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL---VEVRE 687
Query: 270 SFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPS 329
+ S + D L+ AE AEAL G +L L + T +E S
Sbjct: 688 AL--SRATLQRDMLQ-----AEKAEVAEALTKA--EAGRVELEL-SMTKLRAEEASLQDS 737
Query: 330 PSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTR 389
S +S L L ++ L + + Q+E EK + LQ Q+Q E E+QE++
Sbjct: 738 LSKLSALNESLAQDKLD-LNRLVAQLEEEK----SALQGRQRQAEQEATVAREEQERLEE 792
Query: 390 LTENLSALRR-----LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
L R+ L+ +++ Q AL+ + H
Sbjct: 793 LRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH------------------------- 827
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
E +L+EQL L RE + E+ R EA+ Q V LE+A+R ++E LA+
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQE--LEQARREAQRQ-----VEALERAAR-EKEALAKEHA 879
Query: 505 ELKKVSDVAGETQG-SLSVAQDELVTFSEEL-ANLYHHVCMCNNETPNRVMLDYYREGQG 562
L V VA E +G +LS L E L +L+ R L+ +
Sbjct: 880 GL-AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938
Query: 563 GAGRTSPGGRTSPEARGRRSPIL-------LPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
A T G E G R I+ L K L+A + +A+ S ++
Sbjct: 939 LAKETLTG-----ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 616 PLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEE 675
L +RE + + R Q++ ++L R++ +EL ++ +KE L EE
Sbjct: 994 DLQRLQREKEAAWRELEAERAQLQ---------SQLQREQ---EELLARLEAEKEELSEE 1041
Query: 676 ILKLKS-------LLSTKREQITTL----RTVLKANKQTAEVALANLKSKYENEKAMVTE 724
I L+ L ++++Q +L +T L +LA + + E +K
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQS 1101
Query: 725 TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRM 784
+ R+ + AL S LR + A R + E++R A D K +S LR
Sbjct: 1102 RQEQDRSTVNALT------SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLRE 1155
Query: 785 AIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
A + L +L LLE + RR +A K +
Sbjct: 1156 AEE----LRTQLRLLEDARDGLRRELLEAQRKLR 1185
Score = 69.7 bits (169), Expect = 1e-11
Identities = 177/817 (21%), Positives = 298/817 (36%), Gaps = 128/817 (15%)
Query: 29 LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTN 88
L EL E R+ ++ E +E +L+ E + EA+R E+L+ A +A +
Sbjct: 1173 LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE 1232
Query: 89 HKKVAADGESREESLI-----QESASKE--------QYYVRKVLELQTELKQLRNVLTNT 135
+ E +E+ L + + KE Q R LE + EL++LR +
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
Query: 136 QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
SEN RL +EL E+ + + ++ +E RLL+ + LE LQ
Sbjct: 1293 DSENTRLG---RELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQ 1349
Query: 196 SVLRQNQVEFEGLKHEIK-RLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK 254
L++ + EF + + LEE QL+ A R LE LE + E
Sbjct: 1350 RKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHA--------RGLELKLEAARAEAA-- 1399
Query: 255 NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--EALVNGFEHGGLAKLP 312
EL +S + L L ++ AAE AL G GL + P
Sbjct: 1400 -----ELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGL---GLGRAP 1450
Query: 313 LDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQ 372
P P+ L S + + + G +
Sbjct: 1451 SPAPRPVPGSPARDAPAEGSGEGLNSPSTL-------ECSPGSQPPSPGPATSPASPDLD 1503
Query: 373 LEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGP 432
E RG+L E +++ LR ++ RQ A + E +RDS
Sbjct: 1504 PEAVRGALREFLQELRSAQRERDELRTQTSALNRQLA-EMEAERDSATSR---------- 1552
Query: 433 EILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKAS 492
A + AVAE+ E R + S +A A E R E E +A ++V+ LE++
Sbjct: 1553 ---ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSL 1609
Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV 552
+ L ++++ K+ + +G + E++ SE V
Sbjct: 1610 QATESELRASQEKISKMKANETKLEGDKRRLK-EVLDASES----------------RTV 1652
Query: 553 MLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSS 612
L+ R G + S G + EA+ + L DS G+
Sbjct: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQA---------LQDRVDSLQRQVADSEVKAGT- 1702
Query: 613 LPSPLSDPRREPMNIYNLIAIIRDQIKHL-QAAVDRTTELSRQRIASQELGPAV---DKD 668
L + + +RD+++ L +A + L+ R + L A+ + D
Sbjct: 1703 LQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD 1762
Query: 669 KEALMEEILKLKSLLSTKR-------EQITTLR---TVLKANKQTAEVALANLKS---KY 715
++ L E + + LS R EQ+ TLR L+ + AE L L+ +
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR 1822
Query: 716 ENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK 775
+ +A T+ KL++E + L+E +L +QR LA E EK
Sbjct: 1823 QEGEAAALNTVQKLQDERRLLQE---------------------RLGSLQRALAQLEAEK 1861
Query: 776 KTLNSLLRMAIQQKLALTQRLELLELD----HEQTRR 808
+ + + ++AL + L+ +E + HE T R
Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898
Score = 68.9 bits (167), Expect = 2e-11
Identities = 174/819 (21%), Positives = 320/819 (39%), Gaps = 114/819 (13%)
Query: 13 LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-LKLQFEELEVDYEA- 70
L ++ + + L+ E+ R+ LA++ E+ + A AV E Q L+L+ ELE
Sbjct: 77 LSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRG 136
Query: 71 -IRSEMEQLKEAFGQAHTNHKKVAA--DGESREESLIQESASKEQYYVRKVLELQTELKQ 127
+R +E ++ + + +K+ A +G+ R+ L+Q K Y ++ EL+ +L +
Sbjct: 137 LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
Query: 128 LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
L Q L++ + +++ +R ++E + R A L Q + L E+
Sbjct: 197 RSGELEQ------------QRLRDTEHSQDLESALIR--LEEEQQRSASLAQVNAMLREQ 242
Query: 188 NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET- 246
L Q + L +I+++ + +LE +E + R+ EE+
Sbjct: 243 ----------LDQAGSANQALSEDIRKVTNDWTRCRKELEH----REAAWRREEESFNAY 288
Query: 247 LKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
E + L +++ + + + D L+ + A + + G G
Sbjct: 289 FSNEHSRLLLLWRQVVGFRRLVSEV---KMFTERDLLQLGGELARTSRAVQEAGLGLSTG 345
Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK--LKQQLMQMEREKAGLLA 364
+L + +K+ L L + L +L +++ L QQ MQ + +KA L A
Sbjct: 346 --LRLAESRAEAALEKQAL------LQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA 397
Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHED-GD 423
+ + ++ E+ + LTE L AL L+ + Q AL+ E + D
Sbjct: 398 RVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRL--QEQAALETEDGEGLQQTLRD 455
Query: 424 YYEVDINGPEI---LACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
+ ++ E L+ A A G LR L R+ R + + A
Sbjct: 456 LAQAVLSDSESGVQLSGSERTADASNGSLR-GLSGQRTPSPPRRSSPGRGRSPRRGPSPA 514
Query: 481 LTEKVSL------LEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
++ +L L K Q +++ R E D+ G + LS ++ E E+L
Sbjct: 515 CSDSSTLALIHSALHKRQLQVQDMRGRYEAS----QDLLGTLRKQLSDSESERRALEEQL 570
Query: 535 ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPE 594
L R D + A R R++ E R L +A +
Sbjct: 571 QRL-------------RDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQ 617
Query: 595 AGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA-AVDRTTELSR 653
+ L + + RR+ RD+++ Q AV + R
Sbjct: 618 -------QAEELRQEREKLQAAQEELRRQ-----------RDRLEEEQEDAVQDGARVRR 659
Query: 654 QRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKS 713
+ S ++ + L +E+++++ LS + T R +L+A K AEVA A +
Sbjct: 660 ELERSHRQLEQLEGKRSVLAKELVEVREALS----RATLQRDMLQAEK--AEVAEA--LT 711
Query: 714 KYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED 773
K E + + +M KLR E +L++ + S+L A +LD + R +A E+
Sbjct: 712 KAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ------DKLD-LNRLVAQLEE 764
Query: 774 EKKTLNSLLRMAIQQKLAL---TQRLELLELDHEQTRRG 809
EK L R A Q+ +RLE L L+ E R+G
Sbjct: 765 EKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG 803
Score = 60.8 bits (146), Expect = 5e-09
Identities = 112/534 (20%), Positives = 209/534 (39%), Gaps = 62/534 (11%)
Query: 16 EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
+ PE +R ++ EL RE+ + + + L Q E+E + ++ S
Sbjct: 1501 DLDPEAVRGALREFLQELRSAQRERDE-------LRTQTSALNRQLAEMEAERDSATSRA 1553
Query: 76 EQLKEAFGQAHTNHKKVAA--DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
QL++A ++ + V G E +L +ES + + R L+ ++ L L
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLD---QVATLERSLQ 1610
Query: 134 NTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQK 193
T+SE ++K +E + RL++ + + R +L LE E LQ+
Sbjct: 1611 ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE---LQR 1667
Query: 194 QVSVLRQNQVEFEGLKHEIKRLEEE---TEYLNSQLEDAIRLKEISERQLEEALETLKTE 250
L + + + L+ + L+ + +E L+ + + ++EE+ L
Sbjct: 1668 SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL--- 1724
Query: 251 REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
R++ L + L+ + +S +LH+ D +A
Sbjct: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
Query: 311 LPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE--IQKLKQQLMQMEREKAGLLAT--- 365
L + T + E V+DL + +E +Q+L++ L Q + +A L T
Sbjct: 1785 SSLGEQVQTLRGE---------VADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQK 1835
Query: 366 LQDTQKQLEHTRGSLS-----------EQQEKVTRLTENLSALRRLQASKERQTALDNEK 414
LQD ++ L+ GSL E + RL ++ ALRR ER+ +E
Sbjct: 1836 LQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHED 1895
Query: 415 DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR----EAQHAEE 470
+ + + G E+ + A + +L Q+ L +H +AQ +
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAE---AQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Query: 471 KGRYEAE----GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSL 520
+ + E E QA TE+ LE R R+ + LE++ VS + G+ Q L
Sbjct: 1953 ELQQEVERLRSAQAQTERT--LEARERAHRQRVRGLEEQ---VSTLKGQLQQEL 2001
Score = 41.2 bits (95), Expect = 0.004
Identities = 94/446 (21%), Positives = 170/446 (38%), Gaps = 57/446 (12%)
Query: 2 SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETT--REKIQAAEYGLAVLEEKHQLKL 59
SA S + + V E++ E R+ RLS AE E ++ +E E+
Sbjct: 1548 SATSRARQLQKAVAESE-EARRSVDGRLSGVQAELALQEESVRRSE------RERRATLD 1600
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL-IQESASKEQYYVRKV 118
Q LE +A SE+ +E + N K+ D +E L ES + + R+
Sbjct: 1601 QVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660
Query: 119 LE-------------------LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQ 159
LE LQ + L+ + +++ + L + L VE
Sbjct: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 160 RGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQN-QVEFEGL---------- 208
G LRD ++ A+ + ++N+ LQK ++ + QV E L
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 209 KHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK----NSLRKELSHY 264
+ + L E+ + L ++ D + +E QL++ E L+ +E + N+++K
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840
Query: 265 MSIND---SFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
+ + S + + + + A D AL L K+ + S
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVAL-----RRTLDKVEREKLRSHED 1895
Query: 322 KEGLAPPSPSLVSDLL-SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
L+ L L +EL ++E Q+ Q+ Q+E + L + Q +++ + L
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQR---QIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Query: 381 SEQQEKVTRLTENLSALRRLQASKER 406
QQE V RL + R ++ER
Sbjct: 1953 ELQQE-VERLRSAQAQTERTLEARER 1977
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 95.5 bits (236), Expect = 2e-19
Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)
Query: 35 ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
+ T+E+ Q AE L LE+KH +L + ++ +++ E + +A ++AA
Sbjct: 862 QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 95 DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
+ EE L + A E+ R +LQ E K++ + + + + E + Q+L+
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 155 NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
E + +L D+I L+ D ++L +E L++++S L N E E +
Sbjct: 975 TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 213 KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
+L+ + E + S+LE ++ +E S ++LE+ L+ + EQ L+ +++ + +
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1084
Query: 269 DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
+ L +L + D+ A+ NN + E ++ + ++ NK K+
Sbjct: 1085 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 323 EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
+ L +L ++L L+ + Q Q+L ++ +L A ++T+ +
Sbjct: 1143 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 381 SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
+ + V LTE L +R +A+ LD K E+ D
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1236
Query: 441 VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
AGELR +A +E +H +K + EA+ Q L K S E+A + + +
Sbjct: 1237 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 501 RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
+L+ E++ V+ + E +G ++ + S +L + + ET ++ + +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1339
Query: 561 QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
Q R S + E +++ L + + S+L LSD
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1376
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
+++ + + + + + K Q ++ T+ ++ A+ + ++K K L +E+ L
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1433
Query: 681 SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
L +R+ ++ L + K ++ AE N+ SKY +E+ A
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 723 TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
E ++ + E LKA ED + + T+ +E TQL+E+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 765 QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
+ +L A ED K + L + +++ L ++L E + E R+
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 810 RAKAAPKTK 818
RA AA K
Sbjct: 1612 RALAAAAKK 1620
Score = 80.1 bits (196), Expect = 8e-15
Identities = 185/868 (21%), Positives = 341/868 (39%), Gaps = 123/868 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
+ E AR E Q L E++ L EL +T T+++++A E + VL++ +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
+ E +V + +R + Q E + K+ A+ + +++L +E+A
Sbjct: 1188 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1234
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
+L EL+ L + + ++L + QEL+ + E R L D + +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1284
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
LQ +V + E EG + +L ++ L+SQL+D L + RQ
Sbjct: 1285 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 240 LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
L+ E++NSL+ +L M + H+S ++ S D+ + D +
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1386
Query: 300 VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
V E G L + + + K E + DL+ +L+ +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K +++ Q+ E+ + + D + + E +E +EK T+ LS R L+ + E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1497
Query: 406 RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
+ L+ +D S +D + +E++ L + + EL ++L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1556
Query: 455 ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
A E KG++E + QA E+ + RQ E LE E K+ + A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 514 GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
+ L + D + EE + M D+ RE +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1668
Query: 568 SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
T+ E A+ + ++ L + L A E R AD + + SSL + L
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 619 D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
D RR I L + ++ +++A DR + ++Q S EL K++ A
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 674 EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
+ + K L S E +++ K+ E +A L+ + E E L+ +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 734 KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
K LKE R M + + ++ ++ +++RQL AE+E + +N A ++KL
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1903
Query: 791 ALTQRLELLELDHEQTRRGRAKAAPKTK 818
+ EL E GR A K+K
Sbjct: 1904 ----QRELDEATESNEAMGREVNALKSK 1927
Score = 76.3 bits (186), Expect = 1e-13
Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+E + L E L +L T +A E + + +K +L+ E+E +
Sbjct: 878 LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 930
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
+E+ ++ Q KK+A EE L +E A++++ + KV +L+ E+
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 126 ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
+++ ++ TN E E+ L + + + + +E++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 168 KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
+E + + +L D S+ E+ LQ Q++ L+ Q + E L+ + RL++E N+ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 227 -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
E A R K E +R L E LE LKTE E + LR
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
+ +++ L +LD S +A + E L E AK L
Sbjct: 1171 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
D T +KE +DL EL + +++Q+L+ + ER
Sbjct: 1223 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 358 EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
+A L + Q ++E G L+E + K +L +++++L +LQ ++E RQ
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 411 DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
+ K R E+ D + ++ + L + + +++L+ ST EA E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1391
Query: 467 HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
E K R++ E + LT++ EKA+ D +LEK T+ L D+
Sbjct: 1392 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1431
Query: 527 LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
LV + L + N E R E + + + R EAR + + L
Sbjct: 1432 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 586 -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
L + L A EA T + L S D + + + Q++ ++
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 644 AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
++ EL + A+++ ++ + +AL + + L + EQ R L+
Sbjct: 1547 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 704 AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
E L + + ++A+ KL +LK L+ A + R + + Q+ +
Sbjct: 1601 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 764 MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
QR+L ED + + + + A + +K A + +L++L + RA+
Sbjct: 1657 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Score = 74.3 bits (181), Expect = 4e-13
Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)
Query: 6 EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
EEEE AR LVM+ Q L E K L +++ T +
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 45 EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
E + + K++ + ELEV E R E+E+LK G A H+++ AD +++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1078
Query: 101 ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
L + A KE+ + L E+ Q N L + ++ + ++L + E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 158 IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
Q+ L ++++ K L + +E +++V+VL++ ++ E HE + E
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1197
Query: 217 -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
+ E L QLE R K + +++ LE+ L E ++E+ H
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 269 DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
++ DG + +D + N+ E+ V G + K K
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 325 LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
L L + +LN+S E L+ QL +ER + L L D+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 370 QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
+K+L+ T +L E +++ + ENL+ Q +E+ A D EK ++ ++ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
VD++ L + +L + K + S + + EA+ E++ + + +A
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
L E + E+ R ++ L A +E + DV +++ +L +E+ T EEL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 535 ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
A L V M + D + + R E
Sbjct: 1552 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 586 LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
+ L A + +G D S+ L + + D +RE +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 629 NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
+ A ++ K ++ +L A++ D +KE L EE L S LS
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1723
Query: 689 QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
R L+ K+ E +A L+ + E E+ T+ +L NEL +
Sbjct: 1724 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 739 DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
A S R + E ++L EM+ +AA E + L + ++K
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 791 ALTQRLE 797
A T+ L+
Sbjct: 1839 AATKSLK 1845
Score = 62.0 bits (149), Expect = 2e-09
Identities = 59/291 (20%), Positives = 136/291 (46%), Gaps = 14/291 (4%)
Query: 14 VMEAQPEWLRAEVKRLSHELA-ETTREKIQAAEYGL-AVLEEKHQLKLQFEELEVDYEAI 71
+M+ Q + AE R +L E E++ ++ G A+ +EK +L+ + +LE + E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 72 RSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV 131
+ ME + + +A T + ++ + E S Q++ S Q R+ EL+++L ++
Sbjct: 1749 QGNMEAMSDRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 132 LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISL 191
+ + +A++ ++ ++ + VE + + K K ++ +L + ++E+E
Sbjct: 1808 VKSKFKST--IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 192 QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
++ + + LK +++ EEE++ +N+ + +R+L+EA E+ +
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------RRKLQRELDEATESNEAMG 1918
Query: 252 EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
+ N+L+ +L SF S ++ +D + E + +A NG
Sbjct: 1919 REVNALKSKLRR--GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNG 1967
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
K+K LL R E++ L+ K+ + A LK + E + + +TE L+ +L+A
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898
Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
E A +R A + E L EM+ +L ED + L + + QQ L L ++
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
LE E ++ + + A K K
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIK 981
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 95.5 bits (236), Expect = 2e-19
Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)
Query: 35 ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
+ T+E+ Q AE L LE+KH +L + ++ +++ E + +A ++AA
Sbjct: 869 QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 95 DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
+ EE L + A E+ R +LQ E K++ + + + + E + Q+L+
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 155 NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
E + +L D+I L+ D ++L +E L++++S L N E E +
Sbjct: 982 TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 213 KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
+L+ + E + S+LE ++ +E S ++LE+ L+ + EQ L+ +++ + +
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1091
Query: 269 DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
+ L +L + D+ A+ NN + E ++ + ++ NK K+
Sbjct: 1092 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 323 EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
+ L +L ++L L+ + Q Q+L ++ +L A ++T+ +
Sbjct: 1150 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 381 SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
+ + V LTE L +R +A+ LD K E+ D
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1243
Query: 441 VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
AGELR +A +E +H +K + EA+ Q L K S E+A + + +
Sbjct: 1244 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 501 RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
+L+ E++ V+ + E +G ++ + S +L + + ET ++ + +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1346
Query: 561 QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
Q R S + E +++ L + + S+L LSD
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1383
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
+++ + + + + + K Q ++ T+ ++ A+ + ++K K L +E+ L
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1440
Query: 681 SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
L +R+ ++ L + K ++ AE N+ SKY +E+ A
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 723 TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
E ++ + E LKA ED + + T+ +E TQL+E+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 765 QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
+ +L A ED K + L + +++ L ++L E + E R+
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 810 RAKAAPKTK 818
RA AA K
Sbjct: 1619 RALAAAAKK 1627
Score = 80.1 bits (196), Expect = 8e-15
Identities = 185/868 (21%), Positives = 341/868 (39%), Gaps = 123/868 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
+ E AR E Q L E++ L EL +T T+++++A E + VL++ +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
+ E +V + +R + Q E + K+ A+ + +++L +E+A
Sbjct: 1195 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1241
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
+L EL+ L + + ++L + QEL+ + E R L D + +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1291
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
LQ +V + E EG + +L ++ L+SQL+D L + RQ
Sbjct: 1292 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 240 LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
L+ E++NSL+ +L M + H+S ++ S D+ + D +
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1393
Query: 300 VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
V E G L + + + K E + DL+ +L+ +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K +++ Q+ E+ + + D + + E +E +EK T+ LS R L+ + E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1504
Query: 406 RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
+ L+ +D S +D + +E++ L + + EL ++L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1563
Query: 455 ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
A E KG++E + QA E+ + RQ E LE E K+ + A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 514 GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
+ L + D + EE + M D+ RE +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1675
Query: 568 SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
T+ E A+ + ++ L + L A E R AD + + SSL + L
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 619 D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
D RR I L + ++ +++A DR + ++Q S EL K++ A
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 674 EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
+ + K L S E +++ K+ E +A L+ + E E L+ +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 734 KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
K LKE R M + + ++ ++ +++RQL AE+E + +N A ++KL
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1910
Query: 791 ALTQRLELLELDHEQTRRGRAKAAPKTK 818
+ EL E GR A K+K
Sbjct: 1911 ----QRELDEATESNEAMGREVNALKSK 1934
Score = 76.3 bits (186), Expect = 1e-13
Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+E + L E L +L T +A E + + +K +L+ E+E +
Sbjct: 885 LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 937
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
+E+ ++ Q KK+A EE L +E A++++ + KV +L+ E+
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 126 ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
+++ ++ TN E E+ L + + + + +E++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 168 KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
+E + + +L D S+ E+ LQ Q++ L+ Q + E L+ + RL++E N+ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 227 -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
E A R K E +R L E LE LKTE E + LR
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
+ +++ L +LD S +A + E L E AK L
Sbjct: 1178 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
D T +KE +DL EL + +++Q+L+ + ER
Sbjct: 1230 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 358 EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
+A L + Q ++E G L+E + K +L +++++L +LQ ++E RQ
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 411 DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
+ K R E+ D + ++ + L + + +++L+ ST EA E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1398
Query: 467 HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
E K R++ E + LT++ EKA+ D +LEK T+ L D+
Sbjct: 1399 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1438
Query: 527 LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
LV + L + N E R E + + + R EAR + + L
Sbjct: 1439 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 586 -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
L + L A EA T + L S D + + + Q++ ++
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 644 AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
++ EL + A+++ ++ + +AL + + L + EQ R L+
Sbjct: 1554 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 704 AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
E L + + ++A+ KL +LK L+ A + R + + Q+ +
Sbjct: 1608 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 764 MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
QR+L ED + + + + A + +K A + +L++L + RA+
Sbjct: 1664 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Score = 74.3 bits (181), Expect = 4e-13
Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)
Query: 6 EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
EEEE AR LVM+ Q L E K L +++ T +
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 45 EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
E + + K++ + ELEV E R E+E+LK G A H+++ AD +++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1085
Query: 101 ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
L + A KE+ + L E+ Q N L + ++ + ++L + E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 158 IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
Q+ L ++++ K L + +E +++V+VL++ ++ E HE + E
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1204
Query: 217 -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
+ E L QLE R K + +++ LE+ L E ++E+ H
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 269 DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
++ DG + +D + N+ E+ V G + K K
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 325 LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
L L + +LN+S E L+ QL +ER + L L D+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 370 QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
+K+L+ T +L E +++ + ENL+ Q +E+ A D EK ++ ++ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
VD++ L + +L + K + S + + EA+ E++ + + +A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
L E + E+ R ++ L A +E + DV +++ +L +E+ T EEL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 535 ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
A L V M + D + + R E
Sbjct: 1559 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 586 LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
+ L A + +G D S+ L + + D +RE +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 629 NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
+ A ++ K ++ +L A++ D +KE L EE L S LS
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1730
Query: 689 QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
R L+ K+ E +A L+ + E E+ T+ +L NEL +
Sbjct: 1731 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 739 DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
A S R + E ++L EM+ +AA E + L + ++K
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 791 ALTQRLE 797
A T+ L+
Sbjct: 1846 AATKSLK 1852
Score = 62.0 bits (149), Expect = 2e-09
Identities = 59/291 (20%), Positives = 136/291 (46%), Gaps = 14/291 (4%)
Query: 14 VMEAQPEWLRAEVKRLSHELA-ETTREKIQAAEYGL-AVLEEKHQLKLQFEELEVDYEAI 71
+M+ Q + AE R +L E E++ ++ G A+ +EK +L+ + +LE + E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 72 RSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV 131
+ ME + + +A T + ++ + E S Q++ S Q R+ EL+++L ++
Sbjct: 1756 QGNMEAMSDRVRKA-TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 132 LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISL 191
+ + +A++ ++ ++ + VE + + K K ++ +L + ++E+E
Sbjct: 1815 VKSKFKST--IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 192 QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
++ + + LK +++ EEE++ +N+ + +R+L+EA E+ +
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN-------RRKLQRELDEATESNEAMG 1925
Query: 252 EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
+ N+L+ +L SF S ++ +D + E + +A NG
Sbjct: 1926 REVNALKSKLRR--GNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNG 1974
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
K+K LL R E++ L+ K+ + A LK + E + + +TE L+ +L+A
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905
Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
E A +R A + E L EM+ +L ED + L + + QQ L L ++
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
LE E ++ + + A K K
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIK 988
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 95.5 bits (236), Expect = 2e-19
Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)
Query: 35 ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
+ T+E+ Q AE L LE+KH +L + ++ +++ E + +A ++AA
Sbjct: 869 QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 95 DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
+ EE L + A E+ R +LQ E K++ + + + + E + Q+L+
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 155 NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
E + +L D+I L+ D ++L +E L++++S L N E E +
Sbjct: 982 TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 213 KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
+L+ + E + S+LE ++ +E S ++LE+ L+ + EQ L+ +++ + +
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1091
Query: 269 DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
+ L +L + D+ A+ NN + E ++ + ++ NK K+
Sbjct: 1092 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
Query: 323 EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
+ L +L ++L L+ + Q Q+L ++ +L A ++T+ +
Sbjct: 1150 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 381 SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
+ + V LTE L +R +A+ LD K E+ D
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1243
Query: 441 VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
AGELR +A +E +H +K + EA+ Q L K S E+A + + +
Sbjct: 1244 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 501 RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
+L+ E++ V+ + E +G ++ + S +L + + ET ++ + +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1346
Query: 561 QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
Q R S + E +++ L + + S+L LSD
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1383
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
+++ + + + + + K Q ++ T+ ++ A+ + ++K K L +E+ L
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1440
Query: 681 SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
L +R+ ++ L + K ++ AE N+ SKY +E+ A
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 723 TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
E ++ + E LKA ED + + T+ +E TQL+E+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 765 QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
+ +L A ED K + L + +++ L ++L E + E R+
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 810 RAKAAPKTK 818
RA AA K
Sbjct: 1619 RALAAAAKK 1627
Score = 80.5 bits (197), Expect = 6e-15
Identities = 186/872 (21%), Positives = 342/872 (39%), Gaps = 123/872 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
+ E AR E Q L E++ L EL +T T+++++A E + VL++ +
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
+ E +V + +R + Q E + K+ A+ + +++L +E+A
Sbjct: 1195 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1241
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
+L EL+ L + + ++L + QEL+ + E R L D + +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1291
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
LQ +V + E EG + +L ++ L+SQL+D L + RQ
Sbjct: 1292 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 240 LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
L+ E++NSL+ +L M + H+S ++ S D+ + D +
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1393
Query: 300 VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
V E G L + + + K E + DL+ +L+ +S +
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K +++ Q+ E+ + + D + + E +E +EK T+ LS R L+ + E
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1504
Query: 406 RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
+ L+ +D S +D + +E++ L + + EL ++L+
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1563
Query: 455 ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
A E KG++E + QA E+ + RQ E LE E K+ + A
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 514 GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
+ L + D + EE + M D+ RE +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1675
Query: 568 SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
T+ E A+ + ++ L + L A E R AD + + SSL + L
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735
Query: 619 D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
D RR I L + ++ +++A DR + ++Q S EL K++ A
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1795
Query: 674 EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
+ + K L S E +++ K+ E +A L+ + E E L+ +
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 734 KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
K LKE R M + + ++ ++ +++RQL AE+E + +N A ++KL
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1910
Query: 791 ALTQRLELLELDHEQTRRGRAKAAPKTKPATP 822
+ EL E GR A K+K P
Sbjct: 1911 ----QRELDEATESNEAMGREVNALKSKLRGP 1938
Score = 76.3 bits (186), Expect = 1e-13
Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+E + L E L +L T +A E + + +K +L+ E+E +
Sbjct: 885 LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 937
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
+E+ ++ Q KK+A EE L +E A++++ + KV +L+ E+
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 126 ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
+++ ++ TN E E+ L + + + + +E++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 168 KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
+E + + +L D S+ E+ LQ Q++ L+ Q + E L+ + RL++E N+ L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 227 -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
E A R K E +R L E LE LKTE E + LR
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
+ +++ L +LD S +A + E L E AK L
Sbjct: 1178 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229
Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
D T +KE +DL EL + +++Q+L+ + ER
Sbjct: 1230 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 358 EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
+A L + Q ++E G L+E + K +L +++++L +LQ ++E RQ
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 411 DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
+ K R E+ D + ++ + L + + +++L+ ST EA E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1398
Query: 467 HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
E K R++ E + LT++ EKA+ D +LEK T+ L D+
Sbjct: 1399 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1438
Query: 527 LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
LV + L + N E R E + + + R EAR + + L
Sbjct: 1439 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 586 -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
L + L A EA T + L S D + + + Q++ ++
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 644 AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
++ EL + A+++ ++ + +AL + + L + EQ R L+
Sbjct: 1554 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 704 AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
E L + + ++A+ KL +LK L+ A + R + + Q+ +
Sbjct: 1608 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 764 MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
QR+L ED + + + + A + +K A + +L++L + RA+
Sbjct: 1664 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Score = 74.3 bits (181), Expect = 4e-13
Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)
Query: 6 EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
EEEE AR LVM+ Q L E K L +++ T +
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 45 EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
E + + K++ + ELEV E R E+E+LK G A H+++ AD +++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1085
Query: 101 ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
L + A KE+ + L E+ Q N L + ++ + ++L + E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 158 IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
Q+ L ++++ K L + +E +++V+VL++ ++ E HE + E
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1204
Query: 217 -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
+ E L QLE R K + +++ LE+ L E ++E+ H
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 269 DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
++ DG + +D + N+ E+ V G + K K
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 325 LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
L L + +LN+S E L+ QL +ER + L L D+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 370 QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
+K+L+ T +L E +++ + ENL+ Q +E+ A D EK ++ ++ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
VD++ L + +L + K + S + + EA+ E++ + + +A
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
L E + E+ R ++ L A +E + DV +++ +L +E+ T EEL
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 535 ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
A L V M + D + + R E
Sbjct: 1559 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 586 LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
+ L A + +G D S+ L + + D +RE +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 629 NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
+ A ++ K ++ +L A++ D +KE L EE L S LS
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1730
Query: 689 QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
R L+ K+ E +A L+ + E E+ T+ +L NEL +
Sbjct: 1731 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 739 DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
A S R + E ++L EM+ +AA E + L + ++K
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 791 ALTQRLE 797
A T+ L+
Sbjct: 1846 AATKSLK 1852
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
K+K LL R E++ L+ K+ + A LK + E + + +TE L+ +L+A
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905
Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
E A +R A + E L EM+ +L ED + L + + QQ L L ++
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
LE E ++ + + A K K
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIK 988
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 95.5 bits (236), Expect = 2e-19
Identities = 173/849 (20%), Positives = 347/849 (40%), Gaps = 155/849 (18%)
Query: 35 ETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAA 94
+ T+E+ Q AE L LE+KH +L + ++ +++ E + +A ++AA
Sbjct: 862 QKTKERQQKAENELKELEQKHS------QLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 95 DGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQ 154
+ EE L + A E+ R +LQ E K++ + + + + E + Q+L+
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQ-QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 155 NVEIQRGRLRDDIKEYKFREARLLQD--YSELEEENISLQKQVSVLRQNQVEFEGLKHEI 212
E + +L D+I L+ D ++L +E L++++S L N E E +
Sbjct: 975 TAEAKIKKLEDEI---------LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 213 KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE----REQKNSLRKELSHYMSIN 268
+L+ + E + S+LE ++ +E S ++LE+ L+ + EQ L+ +++ + +
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQ 1084
Query: 269 DSFYTSHLHVSLDGLKFSDDAAEPNN------DAEALVNGFEHGGLAKLPLDNKTSTPKK 322
+ L +L + D+ A+ NN + E ++ + ++ NK K+
Sbjct: 1085 LAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
Query: 323 EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL--ATLQDTQKQLEHTRGSL 380
+ L +L ++L L+ + Q Q+L ++ +L A ++T+ +
Sbjct: 1143 D-LGEELEALKTELEDTLDSTATQ---QELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 381 SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
+ + V LTE L +R +A+ LD K E+ D
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN------LDKNKQTLEKENADL---------------- 1236
Query: 441 VAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLA 500
AGELR +A +E +H +K + EA+ Q L K S E+A + + +
Sbjct: 1237 -----AGELRVLGQA------KQEVEH--KKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 501 RLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREG 560
+L+ E++ V+ + E +G ++ + S +L + + ET ++ + +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETRQKLNVS-TKLR 1339
Query: 561 QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
Q R S + E +++ L + + S+L LSD
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQN---LERHI--------------------STLNIQLSDS 1376
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
+++ + + + + + K Q ++ T+ ++ A+ + ++K K L +E+ L
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDDLV 1433
Query: 681 SLLSTKREQITTL-RTVLKANKQTAEVALANLKSKYENEK-----------------AMV 722
L +R+ ++ L + K ++ AE N+ SKY +E+ A
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 723 TETMMKLRNE-------LKALKEDAAT-----------FSSLRAMFATRCDEYITQLDEM 764
E ++ + E LKA ED + + T+ +E TQL+E+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 765 QRQLAAAEDEK---------------KTLNSLLRMAIQQKLALTQRLELLELDHEQTRRG 809
+ +L A ED K + L + +++ L ++L E + E R+
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 810 RAKAAPKTK 818
RA AA K
Sbjct: 1612 RALAAAAKK 1620
Score = 80.5 bits (197), Expect = 6e-15
Identities = 186/872 (21%), Positives = 342/872 (39%), Gaps = 123/872 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAET-----TREKIQAA-EYGLAVLEEKHQLKL 59
+ E AR E Q L E++ L EL +T T+++++A E + VL++ +
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
+ E +V + +R + Q E + K+ A+ + +++L +E+A
Sbjct: 1188 RSHEAQV--QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA----------- 1234
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
+L EL+ L + + ++L + QEL+ + E R L D + +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK---------- 1284
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
LQ +V + E EG + +L ++ L+SQL+D L + RQ
Sbjct: 1285 -----------LQNEVESVTGMLNEAEG---KAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 240 LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
L+ E++NSL+ +L M + H+S ++ S D+ + D +
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLS-DSKKKLQDFAST 1386
Query: 300 VNGFEHG---------GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN-----ISEI 345
V E G L + + + K E + DL+ +L+ +S +
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K +++ Q+ E+ + + D + + E +E +EK T+ LS R L+ + E
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAE------AEAREKETKA---LSLARALEEALE 1497
Query: 406 RQTALDNE--------KDRDSHEDG---DYYEVDINGPEILACKYHVAVAEAGELREQLK 454
+ L+ +D S +D + +E++ L + + EL ++L+
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELE-KSKRALETQMEEMKTQLEELEDELQ 1556
Query: 455 ALRSTHEAREAQHAEEKGRYEAEGQALTEK-VSLLEKASRQDRELLARLEKELKKVSDVA 513
A E KG++E + QA E+ + RQ E LE E K+ + A
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 514 GETQ------GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRT 567
+ L + D + EE + M D+ RE +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL--------QAQMKDFQRELEDARASR 1668
Query: 568 SPGGRTSPE----ARGRRSPIL-LPKGLLAPEAGR--ADGGTGDSSPSPGSSLP--SPLS 618
T+ E A+ + ++ L + L A E R AD + + SSL + L
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728
Query: 619 D-PRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ-RIASQELG---PAVDKDKEALM 673
D RR I L + ++ +++A DR + ++Q S EL K++ A
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ 1788
Query: 674 EEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL 733
+ + K L S E +++ K+ E +A L+ + E E L+ +
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 734 KALKEDAATFSSLRAM---FATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
K LKE R M + + ++ ++ +++RQL AE+E + +N A ++KL
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN-----ANRRKL 1903
Query: 791 ALTQRLELLELDHEQTRRGRAKAAPKTKPATP 822
+ EL E GR A K+K P
Sbjct: 1904 ----QRELDEATESNEAMGREVNALKSKLRGP 1931
Score = 76.3 bits (186), Expect = 1e-13
Identities = 186/890 (20%), Positives = 349/890 (39%), Gaps = 156/890 (17%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+E + L E L +L T +A E + + +K +L+ E+E +
Sbjct: 878 LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEME-------AR 930
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL------ELQTEL--- 125
+E+ ++ Q KK+A EE L +E A++++ + KV +L+ E+
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 126 ---------------KQLRNVLTNTQSENER---LASVAQELKEINQNVEIQRGRLRDDI 167
+++ ++ TN E E+ L + + + + +E++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 168 KEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRLEEETEYLNSQL 226
+E + + +L D S+ E+ LQ Q++ L+ Q + E L+ + RL++E N+ L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 227 -------------------EDAIRLK-EISERQLEEALETLKTEREQ-------KNSLRK 259
E A R K E +R L E LE LKTE E + LR
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDA------AEPNNDAEALVNGFEHGGLAKLPL 313
+ +++ L +LD S +A + E L E AK L
Sbjct: 1171 KREQEVTV--------LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222
Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNI----------------SEIQKLKQQLMQMER 357
D T +KE +DL EL + +++Q+L+ + ER
Sbjct: 1223 DKNKQTLEKEN---------ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 358 EKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE------RQTAL 410
+A L + Q ++E G L+E + K +L +++++L +LQ ++E RQ
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 411 DNEKDRDSHED----GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ 466
+ K R E+ D + ++ + L + + +++L+ ST EA E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE-- 1391
Query: 467 HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
E K R++ E + LT++ EKA+ D +LEK T+ L D+
Sbjct: 1392 --EGKKRFQKEIENLTQQYE--EKAAAYD-----KLEK-----------TKNRLQQELDD 1431
Query: 527 LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGR-TSPGGRTSPEARGRRSPIL 585
LV + L + N E R E + + + R EAR + + L
Sbjct: 1432 LVVDLDNQRQL-----VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 586 -LPKGL-LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQA 643
L + L A EA T + L S D + + + Q++ ++
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 644 AVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQT 703
++ EL + A+++ ++ + +AL + + L + EQ R L+
Sbjct: 1547 QLE---ELEDELQATEDAKLRLEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 704 AEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDE 763
E L + + ++A+ KL +LK L+ A + R + + Q+ +
Sbjct: 1601 YETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 764 MQRQLAAAEDEKKTLNSLLRMAIQ-QKLALTQRLELLELDHEQTRRGRAK 812
QR+L ED + + + + A + +K A + +L++L + RA+
Sbjct: 1657 FQREL---EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Score = 74.3 bits (181), Expect = 4e-13
Identities = 189/907 (20%), Positives = 339/907 (37%), Gaps = 136/907 (14%)
Query: 6 EEEEYAR---------------------LVMEAQPEWLRAEVKRLSHELAETTREKIQAA 44
EEEE AR LVM+ Q L E K L +++ T +
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 45 EYGLAVLEEKHQLKLQFEELEV---DYEAIRSEMEQLKEAF-GQAHTNHKKVAADGESRE 100
E + + K++ + ELEV E R E+E+LK G A H+++ AD +++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQAQI 1078
Query: 101 ESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL---KEINQNVE 157
L + A KE+ + L E+ Q N L + ++ + ++L + E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 158 IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE- 216
Q+ L ++++ K L + +E +++V+VL++ ++ E HE + E
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEM 1197
Query: 217 -----EETEYLNSQLEDAIRLK---EISERQLEEALETLKTEREQKNSLRKELSHYMSIN 268
+ E L QLE R K + +++ LE+ L E ++E+ H
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 269 DSFYTSHLHVSLDG----LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEG 324
++ DG + +D + N+ E+ V G + K K
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 325 LAPPSPSLVSDLLSELNIS--------EIQKLKQQL-------MQMEREKAGLLATLQDT 369
L L + +LN+S E L+ QL +ER + L L D+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 370 QKQLE---HTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDY 424
+K+L+ T +L E +++ + ENL+ Q +E+ A D EK ++ ++ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLT-----QQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTH----EAREAQHAEEKGRYEAEGQA 480
VD++ L + +L + K + S + + EA+ E++ + + +A
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVA------GETQGSLSVAQDELVTFSEEL 534
L E + E+ R ++ L A +E + DV +++ +L +E+ T EEL
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 535 ---------ANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL 585
A L V M + D + + R E
Sbjct: 1552 EDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 586 LPKGLLAPEAGRADGGTGDSSPSPGSS-------------LPSPLSDPRREPMNIY---- 628
+ L A + +G D S+ L + + D +RE +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 629 NLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKRE 688
+ A ++ K ++ +L A++ D +KE L EE L S LS
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE---LASSLSG--- 1723
Query: 689 QITTLRTVLKANKQTAEVALANLKSKYENEKA----------MVTETMMKLRNELKALKE 738
R L+ K+ E +A L+ + E E+ T+ +L NEL +
Sbjct: 1724 -----RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 739 DAATFSSLRAMFATRCDEYITQLDEMQ--------RQLAAAEDEKKTLNSLLRMAIQQKL 790
A S R + E ++L EM+ +AA E + L + ++K
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 791 ALTQRLE 797
A T+ L+
Sbjct: 1839 AATKSLK 1845
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/143 (27%), Positives = 65/143 (45%), Gaps = 3/143 (2%)
Query: 678 KLKSLLSTKR--EQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
K+K LL R E++ L+ K+ + A LK + E + + +TE L+ +L+A
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898
Query: 736 LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQR 795
E A +R A + E L EM+ +L ED + L + + QQ L L ++
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 796 LELLELDHEQTRRGRAKAAPKTK 818
LE E ++ + + A K K
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIK 981
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 89.7 bits (221), Expect = 1e-17
Identities = 117/578 (20%), Positives = 256/578 (44%), Gaps = 86/578 (14%)
Query: 2 SAPSEEEEYARL--VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLK 58
S E+++ RL V++++ + L+ +K + + ET E+++ A L EE ++L+
Sbjct: 1439 SVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET-EEELKVAHCCLKEQEETINELR 1497
Query: 59 LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRK 117
+ E E + I+ ++E + + ++ IQE KE Q+ +++
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKL------------------QNKIQEIYEKEEQFNIKQ 1539
Query: 118 VLELQ---TELKQ---------------------LRNVLTNTQSENERLASVAQELKEIN 153
+ E+Q ELKQ L N L +Q E + + +E+K +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 154 QNVEIQRGRLRDDIKEY--KFREARLLQDYSELEEENIS-LQKQVSVLRQNQVEFEGLKH 210
+ ++I+R +L+++ KE K +E++ ++Y L+ ++ Q+++ + + +FE K
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQ-EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658
Query: 211 EIKRLEEE----TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQ-KNSLRKELSHYM 265
++ +E E T+ L+ LE+ +R L ETLK ER+Q K +LR+ ++ +
Sbjct: 1659 NLENIETENIRLTQILHENLEE-MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717
Query: 266 SINDSFYTSHLHV-----SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTP 320
+ H+H+ ++D K +E N+ + EH A D K
Sbjct: 1718 EKQEELKIVHMHLKEHQETID--KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE 1775
Query: 321 KKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
+ ++ +++ E Q+ +L + EK L+ + QK LE++ L
Sbjct: 1776 LR--------------IAHMHLKEQQETIDKLRGIVSEKTDKLSNM---QKDLENSNAKL 1818
Query: 381 SEQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKY 439
E+ +++ L L++ + ++++ + ++ K + + +++I LA K
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLN-LAQKL 1877
Query: 440 HVAVAEAGEL---REQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDR 496
H + E + R+ L+ + T + Q E +A + +++ S++ +
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK 1937
Query: 497 ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
E + +L +++ + + + Q L ++DEL +EL
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Score = 82.8 bits (203), Expect = 1e-15
Identities = 181/867 (20%), Positives = 345/867 (39%), Gaps = 168/867 (19%)
Query: 29 LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTN 88
L +AE + K E +E + +L+L +EL+ E + E + G+
Sbjct: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118
Query: 89 HKKVAADGESREESL------------IQESASKEQYYVRKVLELQTELKQLRNVLTNTQ 136
++A E +E +QE S+ Q + ++ L+ ELK L + +
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME 1178
Query: 137 SENERLASVAQE--------------LKEINQNVEIQRGRLRDDIKEYKFREARLLQDYS 182
+E LA E LKE+ ++ E +R LR I+E EA LQ
Sbjct: 1179 TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI---EATGLQTKE 1235
Query: 183 ELEEENISL---QKQVSVLRQNQ-------VEFEGLKHEIKRLEEETEYLNSQLEDAIRL 232
EL+ +I L Q+ + LR++ + + L+ +L+EE L+ + E +
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 233 KEISERQ-LEEALETLKTEREQKNS--LRKELSHYMSINDSFYTSH-----LHVSLDGLK 284
KE+SE Q LE L + K+S L + + +N+ F S L D LK
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355
Query: 285 FSDDAAEPNND------AEALVNGFEHGGLAKLPL-----DNKTS--TPKKEGLAPPSPS 331
+A E +D E L E + L DN+T+ + E P +
Sbjct: 1356 TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSA 1415
Query: 332 LVSDLLSELNIS------------------EIQKLKQQLM----QMEREKAGLLATLQDT 369
L+ + L +S ++Q+L++ L Q++ ++A +T
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLET 1475
Query: 370 QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
+++L+ L EQ+E + L NLS ++ ++Q N+K ++ +
Sbjct: 1476 EEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ--------- 1526
Query: 430 NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE 489
EI + + + E++E++ L+ E R+A+ + + E++ LT ++
Sbjct: 1527 ---EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQS-IESKMLELTNRL---- 1578
Query: 490 KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVT-FSEELANLYHHVCM-CNNE 547
+ S+++ +++ + ++E+K+V + + L E+V E Y + M NE
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 548 TPNRVM-LDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSS 606
T ++ +++ +E T + E R +L + L E R+
Sbjct: 1639 TQEKMCEIEHLKE----QFETQKLNLENIETENIRLTQILHENL---EEMRS-------- 1683
Query: 607 PSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTTELSRQRIASQELGPAV 665
++ R + ++ + + RDQ+K +L+ + R E QE V
Sbjct: 1684 ----------VTKERDDLRSVEETLKVERDQLKENLRETITRDLE-------KQEELKIV 1726
Query: 666 DKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTET 725
+ E I KL+ ++S K +I +N++ E+ +
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKTNEI------------------SNMQKDLEHSNDALKAQ 1768
Query: 726 MMKLRNELKA----LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSL 781
+K++ EL+ LKE T LR + + + D +L MQ+ L + N+
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD----KLSNMQKDL-------ENSNAK 1817
Query: 782 LRMAIQQKLALTQRLELLELDHEQTRR 808
L+ IQ+ A +L L+ D +T++
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQK 1844
Score = 72.0 bits (175), Expect = 2e-12
Identities = 166/832 (19%), Positives = 332/832 (39%), Gaps = 136/832 (16%)
Query: 53 EKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ 112
E + L+ ++ L +DYE +R+E E+++ K+ + E ++ K+Q
Sbjct: 499 ELNSLRADYDNLVLDYEQLRTEKEEME----------LKLKEKNDLDEFEALERKTKKDQ 548
Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
++L E+ L+N++ + + N+ L + E+ + E Q +L++ I K
Sbjct: 549 -----EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKL 603
Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQ-LEDAIR 231
++ YS E+I KQ ++Q + E + + KR E+ +L S+ LE +
Sbjct: 604 ENIKMDLSYS---LESIEDPKQ---MKQTLFDAETVALDAKR---ESAFLRSENLELKEK 654
Query: 232 LKEISE--RQLEEALETLKTEREQKNSLR-----------KELSHYMSINDSFYTSHL-- 276
+KE++ +Q+E ++ +++ E K ++ E++ S+ D L
Sbjct: 655 MKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 277 HVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK--LPLDNKTSTPKK-EGLAPPSPSLV 333
++ L+G K +D E N + E E+ L + + L S P + E L +
Sbjct: 715 NLELEG-KITDLQKELNKEVE------ENEALREEVILLSELKSLPSEVERLRKE----I 763
Query: 334 SDLLSELNI--SEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
D EL+I SE KL +++ E GLL + T+ L T+ + ++
Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF---- 819
Query: 392 ENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE 451
+N L K + +NE+ +I A K+ + G L+
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENER----------MNQEIVNLSKEAQKFD---SSLGALKT 866
Query: 452 QLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSD 511
+L + + + E E + L + S L+ R+ + +L++ L++V
Sbjct: 867 ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926
Query: 512 VAGE------TQGSLSVAQDEL-----------VTFSEELANLYHHVCMCNNETPNRVML 554
+ E Q SL + +D+L + E+L N + + ET N +
Sbjct: 927 LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ-HQETINTLKS 985
Query: 555 DYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLP 614
E G T E + + I + L A D+
Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 615 SPLSDPRREPMNIYNLIAIIRDQIK-----HLQAAVDRTTEL--------SRQRIASQEL 661
L + E + + ++Q+K +++ ++ EL +Q I +QE
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105
Query: 662 GPAVDK--------DKEALMEEILKLKS-LLSTKREQITTLRTVLKANKQTAEVALANLK 712
A+ K D+ A +EE LK KS L K++Q+ ++ + + Q + NLK
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM-SEMQKKINEIENLK 1164
Query: 713 SKYEN----------EKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDE---YIT 759
++ +N E+ + + + + E+K++ ++ L+ F T D YI
Sbjct: 1165 NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIR 1224
Query: 760 QLD----EMQRQLAAA----EDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
+++ + + +L A ++ ++T++ LR ++ +K A + LE H
Sbjct: 1225 EIEATGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEKTAQIINTQDLEKSH 1275
Score = 71.6 bits (174), Expect = 3e-12
Identities = 147/810 (18%), Positives = 309/810 (38%), Gaps = 75/810 (9%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREK-------IQAAEYGLAVLEEKHQLKLQFEELEVD 67
+ ++ E LR E++ S EL T EK + +LEE + K + +
Sbjct: 752 LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811
Query: 68 YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQ 127
Y++ E + K +K V + E + ++ S + Q + + L+TEL
Sbjct: 812 YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS-KEAQKFDSSLGALKTELSY 870
Query: 128 LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
TQ E+ V + L E+ Q E R D + RE L+ +
Sbjct: 871 ------KTQELQEKTREVQERLNEMEQLKEQLENR--DSTLQTVEREKTLITE------- 915
Query: 188 NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
LQ+ + ++ E + LK + L+ E + L S + D + + ++ QL ALE+L
Sbjct: 916 --KLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
Query: 248 KTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGG 307
K +E N+L+ ++S +S N L ++ E ++ + + G +
Sbjct: 974 KQHQETINTLKSKISEEVSRN--------------LHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 308 LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQ 367
+ + K+ + L+ E N + Q L+ + + E+ K L ++
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ-QMLESVIAEKEQLKTDLKENIE 1078
Query: 368 ---DTQKQLEHTRGSLSEQQEKVTRLTENLSALRR---LQASKERQTALDNEKDRDSHED 421
+ Q++L L +QQE V + E A+++ L + +R ++ + S +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQ--EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 422 GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQH---AEEKGRYEAEG 478
+ + +N E ++ + + E L+ +LK T E E + A++ E
Sbjct: 1137 QEKQQQLLNVQEEMS-EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 479 QALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
+++T++ +L++ + L ++++ +T+ L +A L E + L
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 539 HHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRA 598
V + +T + + P E LLP E
Sbjct: 1256 RSV---SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE--------LLPNVKEVSETQET 1304
Query: 599 DGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS 658
+ + + L+ E + + +++IK L T E +
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL------TKERDNLKTIK 1358
Query: 659 QELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKS----K 714
+ L D+ KE + E + K++ S + + + + K +E+ K +
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418
Query: 715 YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
E E +++ + + +E+K++ ++ L+ + + D+ + E+ + E+E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 775 KKTLNSLLRMAIQQKLALTQRLELLELDHE 804
K + L+ Q++ R+ L E + E
Sbjct: 1479 LKVAHCCLKE--QEETINELRVNLSEKETE 1506
Score = 58.9 bits (141), Expect = 2e-08
Identities = 163/860 (18%), Positives = 338/860 (39%), Gaps = 123/860 (14%)
Query: 9 EYARLVMEAQPEWLRAEVKRLSHELAETTR-------EKIQAAEYGLAVLEEKHQLKLQF 61
+Y LV++ E LR E + + +L E E+ + + ++ E LK
Sbjct: 506 DYDNLVLDY--EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563
Query: 62 EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
+ EV + + +E+ E + KK+ +S++ I+ S + ++
Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
+ L V + + E+ L S ELKE + + ++ +DI+ Y+ + +
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 182 SELEEENISLQKQVSVLRQ-----------NQVEFEGLKHEI-KRLEEETEYLNSQLEDA 229
+LE+E S +++ L +E EG ++ K L +E E + E+
Sbjct: 684 VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743
Query: 230 IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS--LDGL---- 283
I L E+ + L +E L+ E + K+ +EL S D ++ +H + GL
Sbjct: 744 ILLSEL--KSLPSEVERLRKEIQDKS---EELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 284 -KFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE---------GLAPPSPSLV 333
K DD A ++ ++ F++ + + K +E L+ +
Sbjct: 799 GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
Query: 334 SDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTEN 393
S L + +E+ Q+L + RE L ++ ++QLE+ +L + + T +TE
Sbjct: 859 SSLGALK--TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916
Query: 394 L--------SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
L + + K+ Q +L E+D+ + D ++I+ E L A+
Sbjct: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL----RNALES 972
Query: 446 AGELREQLKALRS--THEAREAQHAEE-----KGRYEAEGQALTEKVSLLEK------AS 492
+ +E + L+S + E H EE K ++ + + +K L K A
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032
Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL-ANLYHHVCM-CNNETPN 550
+D E++ + K + + + L + ++ E+L +L ++ M N+
Sbjct: 1033 VKDNEIIEQQRKIFSLIQE-----KNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 551 RVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPG 610
R++ D ++ Q ++A E A G+ S +
Sbjct: 1088 RLLGDELKKQQ---------------------------EIVAQEKNHAIKKEGELSRTCD 1120
Query: 611 --SSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKD 668
+ + L + ++ + +++++ +Q ++ L + + ++EL
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENL-KNELKNKEL------T 1173
Query: 669 KEALMEEILKLKSLLSTKREQ---ITTLRTVLKANKQTAEVALANLKSKYENEKAMVTET 725
E + E L+L L+ E+ IT R VLK +++ E +L+ +A +T
Sbjct: 1174 LEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQT 1233
Query: 726 MMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLD------EMQRQLAAAEDEKKTLN 779
+L+ LKE T LR + + + I D ++Q ++ +E++ L
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLP 1293
Query: 780 SLLRMAIQQKLALTQRLELL 799
++ ++ Q+ LELL
Sbjct: 1294 NVKEVSETQE--TMNELELL 1311
Score = 57.4 bits (137), Expect = 5e-08
Identities = 157/781 (20%), Positives = 304/781 (38%), Gaps = 128/781 (16%)
Query: 52 EEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLI------- 104
+E LK Q EE+ ++ A E +QL + + K E+ L+
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTL 409
Query: 105 -QESASKEQYYVRKVLELQTELKQLR-----NVLTNTQSENERLASVAQELKEINQNVEI 158
QE +K + V L ++K N+ TN ++ +L+ L+EI+++V
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS--INLLREIDESVCS 467
Query: 159 QR---GRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRL 215
+ D + E ++ A L L +ENI S L + +++ L + ++L
Sbjct: 468 ESDVFSNTLDTLSEIEWNPATKL-----LNQENIE-----SELNSLRADYDNLVLDYEQL 517
Query: 216 EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSH 275
E E E ++LKE ++ EALE KT+++Q+ L E+S+ ++ H
Sbjct: 518 RTEKE------EMELKLKEKNDLDEFEALER-KTKKDQEMQLIHEISNLKNL-----VKH 565
Query: 276 LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSD 335
V L+ N+ + V L + K E + D
Sbjct: 566 AEVYNQDLE---------NELSSKVELLREKEDQIKKLQEYIDSQKLENIK-------MD 609
Query: 336 LLSEL-NISEIQKLKQQLMQME-------REKAGLLATLQDTQKQLEHTRGSLSEQQEKV 387
L L +I + +++KQ L E RE A L + + +++++ + + + +
Sbjct: 610 LSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDI 669
Query: 388 TRLTENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
L A +++Q KE Q+A + S DG P+ L C +
Sbjct: 670 QLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-------PKDLLCNLELE--- 719
Query: 446 AGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
G++ + K L E EA E+ +E ++L +V L K + E L + E
Sbjct: 720 -GKITDLQKELNKEVEENEA--LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSE 776
Query: 506 LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAG 565
K+ + + +E+ ++LA + + E N L E +
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY--- 833
Query: 566 RTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPM 625
+ E R + ++ L+ EA + D G +L + LS +E
Sbjct: 834 ------KMVLEENERMNQEIVN---LSKEAQKFDSSLG--------ALKTELSYKTQE-- 874
Query: 626 NIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST 685
++++ + +Q ++ +L Q V+++K + E++ + + T
Sbjct: 875 --------LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT 926
Query: 686 KREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSS 745
+T + LK +++ ++ LKS + M +T +LRN L++LK+ T ++
Sbjct: 927 ----LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT 982
Query: 746 LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
L++ + +E+ R L E+ +T + QQK+ + + LE + Q
Sbjct: 983 LKSKIS----------EEVSRNLHMEENTGETKDE-----FQQKMVGIDKKQDLEAKNTQ 1027
Query: 806 T 806
T
Sbjct: 1028 T 1028
Score = 51.2 bits (121), Expect = 4e-06
Identities = 109/626 (17%), Positives = 245/626 (39%), Gaps = 117/626 (18%)
Query: 17 AQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME 76
++ E L+ ++K S L++ E + A+ LEE + + + L E ++ E +
Sbjct: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
Query: 77 QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQ 136
QLKE+ + A D E ++E SKE + V +L+ ++ + +++ Q
Sbjct: 1907 QLKESLQETK------ARDLEIQQELKTARMLSKE--HKETVDKLREKISEKTIQISDIQ 1958
Query: 137 SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ---- 192
+ ++ Q+ + Q E+Q R+++D+ + + Q + E +N+S+Q
Sbjct: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
Query: 193 -------------KQVSVLRQNQVEFEGLKHEIKR------------------------- 214
+++ ++ + + E +K +K
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 215 ---LEEETEYLNSQL-EDAIRLKEISERQLE-----EALETLKTEREQKNSLRKELSHYM 265
L + ++L L E R+KE+ +R E E L L + E++ +KELS +
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 266 SINDS---FYTSHL--------------HVSLDGLKF-SDDAAEPNNDAEALVNGFEHGG 307
N S T H+ H + LK+ + + +N FE
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 308 LAKLP-----------LDNKTSTPKKE----GLAPPSPSLVSDLLSELNISEIQKLK--- 349
+ ++ L P +E L + ++L + + SE +K
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEF 2258
Query: 350 QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-----TENLSALRRLQASK 404
QQ++ +E L +T+ +E + + ++ +++ ++ ++ + +
Sbjct: 2259 QQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFE 2318
Query: 405 ERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH-EAR 463
ER + E ++D + E + L ++A ++ + ++ H +R
Sbjct: 2319 ERSATISKEWEQDLKSLKEKNEKLFKNYQTL----KTSLASGAQVNPTTQDNKNPHVTSR 2374
Query: 464 EAQHAEEKGR------YEAEGQAL--TEKVSLLEKASRQDRELLARLEKELKKVSDVAGE 515
Q EK R +EA+ A+ K+ ++K +++A+L+ ++ + + +
Sbjct: 2375 ATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434
Query: 516 TQGSLSVAQDELV----TFSEELANL 537
T+ ++ V QD++ + EE+ +L
Sbjct: 2435 TKETIQVLQDKVALGAKPYKEEIEDL 2460
Score = 41.2 bits (95), Expect = 0.004
Identities = 74/409 (18%), Positives = 171/409 (41%), Gaps = 57/409 (13%)
Query: 27 KRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAH 86
+R S E ++ Y + EE+H+ +FE +D E+E+ KE
Sbjct: 2160 QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID------EVEKQKELL--IK 2211
Query: 87 TNHKKVAADGESREESLIQESASKEQYYVRKVLE---------LQTELKQLRNVLTNTQS 137
H + D SRE ++ + + + ++ ++L+ ++TE +Q+ +
Sbjct: 2212 IQHLQQDCDVPSRELRDLKLNQNMD-LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ 2270
Query: 138 ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
E + +++++ ++ + R+ + R ++ + +E EE + ++ K+
Sbjct: 2271 FLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEW-- 2328
Query: 198 LRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTE------R 251
+ + + LK + ++L + + L + L ++ ++ + + T+ R
Sbjct: 2329 ----EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384
Query: 252 EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKL 311
E +NSL + S +H +K + E ND A + AK+
Sbjct: 2385 ELENSLHEAKE-----------SAMHKESKIIKMQKEL-EVTNDIIAKLQ-------AKV 2425
Query: 312 PLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQK 371
NK KE + + L ++ EI+ LK +L++++ EK + ++ +K
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVA--LGAKPYKEEIEDLKMKLVKIDLEK---MKNAKEFEK 2480
Query: 372 QLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
++ T+ ++ Q+E + L EN LRR Q +++ ++ + S++
Sbjct: 2481 EISATKATVEYQKEVIRLLREN---LRRSQQAQDTSVISEHTDPQPSNK 2526
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 89.4 bits (220), Expect = 1e-17
Identities = 175/832 (21%), Positives = 321/832 (38%), Gaps = 128/832 (15%)
Query: 50 VLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESAS 109
+ EEK +++ + E EA +++EQL Q ++V A +E+L++E A+
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLH----QEAKRQEEVLARAVQEKEALVREKAA 740
Query: 110 KEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDI-- 167
E ++ ++ + + L L S E L S E ++ N +E+ +G+L I
Sbjct: 741 LEV----RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 168 ----KEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGL----------KHEIK 213
KE E R L+ + E ++ + + Q E EG + E+
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVN 856
Query: 214 RL----EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKE--------L 261
+L E+E + +L A+ E + +LE L+ +TE E + R+E L
Sbjct: 857 QLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESAL 916
Query: 262 SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPK 321
+ S L L K DA++ L +L D K K
Sbjct: 917 CQMQLETEKERVSLLETLLQTQKELADASQQ---------------LERLRQDMKVQKLK 961
Query: 322 KEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
++ + + + EL + Q + L ++ E + LL D QKQ+E + L
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQH-RDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 382 EQ-------QEKVTRLTENLSALRRLQASKERQTA------LDNEKDRDSHEDGDYYEVD 428
Q +++V R+Q ER+ A ++ E+ ++ D
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEAD----S 1076
Query: 429 INGPEILACKYHV--AVAEAGELREQLKALRSTHEAREAQHAEEKGRY--EAEGQALTE- 483
I E+ A + + A E EL Q++ LR + +EA ++ + E E +TE
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ 1136
Query: 484 --KVSLLEKASRQDRELLARLEKELKKVSDVAGETQ-GSLSVAQDELVTFSEELANLYHH 540
+ SL + ++ +L RL ++ +A E Q G+ + AQ +L + L
Sbjct: 1137 QLRASLWAQEAKA-AQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 541 VCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG 600
VC E GG S G P+ G RS L +G L
Sbjct: 1196 VCESRPELSG-----------GGDSAPSVWG-LEPDQNGARS--LFKRGPLLTALS---- 1237
Query: 601 GTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT----------- 649
++ S L ++ ++RDQ++ L+ + T
Sbjct: 1238 ---------AEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ 1288
Query: 650 ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL---RTVLKANKQTAEV 706
+L RQ +QE + + +L E+++L +++ + ++ R + ++ +
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQA 1348
Query: 707 ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQR 766
A NL ++ E+ +A V E + + L+ED T R+ + +E E +R
Sbjct: 1349 AKENLTAQVEHLQAAVVEARAQA-SAAGILEEDLRT---ARSALKLKNEEV-----ESER 1399
Query: 767 QLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
+ A A E+ L A+Q+ LAL + + +T RG+ + K +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451
Score = 80.1 bits (196), Expect = 8e-15
Identities = 128/599 (21%), Positives = 241/599 (40%), Gaps = 88/599 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKR-LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
+E++ ++AQ E R + + L ET +E++ E L +E Q E L
Sbjct: 892 KEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951
Query: 65 EVDYEAIRSEMEQ----LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
D + + + ++ L+ +A K+ A +L +ES+S ++ ++
Sbjct: 952 RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSS----LLQDKMD 1007
Query: 121 LQTELKQLRNVLTNTQSENERLASV--------AQELKEINQNVEIQRGRLRDDIKEYKF 172
LQ +++ L++ L Q +++RL QE I + +E ++ L + E
Sbjct: 1008 LQKQVEDLKSQLV-AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME--- 1063
Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEG-----------LKHEIKRLEEETEY 221
+E RLL L+E + Q+++S LRQ+ E +G L+ E+K E +
Sbjct: 1064 KEQRLLV----LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 222 LNSQLEDAIRLKEISERQL---------------------EEALETLKTEREQKNSLRKE 260
+QL + + I+E+QL E LE L E++ N + +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179
Query: 261 LSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE---HGGLAKLPLDNKT 317
S Y++ L +L + S D+ V G E +G +
Sbjct: 1180 AQLA-----SLYSA-LQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 318 STPKKEGLAPPSPSLVSDLLS-----ELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQ 372
+ E +A L DL ++ ++QKL+++L E EK+ + LQD Q+Q
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
Query: 373 LEHTRGSLSEQQEKVTRLTENLSALRRLQASKE---RQTALDNEKDRDSHE----DGDYY 425
L + S+ + K L L L AS + R+ L + + E +
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL 1353
Query: 426 EVDINGPEILACKYHVAVAEAGELREQLKALRST---------HEAREAQHAEEKGRYE- 475
+ + + + AG L E L+ RS E AQ +E+G +
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413
Query: 476 AEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEEL 534
A+G+AL E ++LL + + E + L +++++ + +L + +L ++E+
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Score = 78.2 bits (191), Expect = 3e-14
Identities = 175/844 (20%), Positives = 336/844 (39%), Gaps = 112/844 (13%)
Query: 28 RLSHELAETTREKIQAAE--------YGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
+L +E E+ RE+ QA + G A+ E L E E + E +R ++++L+
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 80 EAFGQAHTNHKKVAADGESREESL-IQESASKEQYYVRKVLE------------LQTELK 126
+ + ++ D + R + + +Q+ +E R VLE L + +
Sbjct: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
Q+R + + +++ L EL++ +Q +E QRG+++D K+ E L ELEE
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL----ELEE 1564
Query: 187 ENISLQKQVSVLR----QNQVEFEGLKHEIKRLEEETEYL---NSQLEDAIRLKEISERQ 239
+ ++ Q +++ Q + + L H LEE ++ L +SQ+ D + R+
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE 1624
Query: 240 LEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEAL 299
L+E + +K++REQ L+++ H ++ + L + + ++ +D + + L
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEH-LTQDLERRDQELMLQKERIQVLED--QRTRQTKIL 1681
Query: 300 VNGFEHGGLAKLPLDNKTSTPK-------KEGLAPPSPSLVS----DLLSELNISEIQKL 348
E L+ + +T + +EG P S L+ E++
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741
Query: 349 KQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER-- 406
++ + +++ K L LQ +++ T LS++++++ L + L R KE+
Sbjct: 1742 QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSL 1801
Query: 407 QTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV---AVAEAGELREQLKALRSTHEAR 463
Q+ LD + + D + + + + V A A G L + L+ H
Sbjct: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
Query: 464 EAQHAEEKGRYEAE-------GQALTEKVSLLEKASRQDRELLARL-----------EKE 505
+ H E+ R E E QAL E + L SR+ + L L E E
Sbjct: 1862 Q-DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVE 1920
Query: 506 LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAG 565
+ + D + Q L EL E + H E R + +E G A
Sbjct: 1921 TRALQDSWLQAQAVLKERDQELEALRAESQSSRH------QEEAARARAEALQEALGKAH 1974
Query: 566 RTSPGGRTSPEARGRRSPILLPKGLLAPEAGRAD-GGTGDSSPSPGSSLPSPLSDPRREP 624
G + S L EA A + D+ + L L R +
Sbjct: 1975 AALQGKEQHLLEQAELSRSL--------EASTATLQASLDACQAHSRQLEEAL---RIQE 2023
Query: 625 MNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
I + ++ ++ LQ A+ R EL Q+ Q L ++ + + E +++ K L
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL---AQRVQENMIQEKQNL 2080
Query: 684 STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
+RE+ + ++ E+ L ++ E E + ET RN L+AL T
Sbjct: 2081 GQEREE----EEIRGLHQSVRELQLT--LAQKEQEILELRETQQ--RNNLEALPHSHKT- 2131
Query: 744 SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
+ +E +LD ++ +L + E + L + LR +++ ++ + L L
Sbjct: 2132 --------SPMEEQSLKLDSLEPRL---QRELERLQAALRQTEAREIEWREKAQDLALSL 2180
Query: 804 EQTR 807
QT+
Sbjct: 2181 AQTK 2184
Score = 66.6 bits (161), Expect = 9e-11
Identities = 111/545 (20%), Positives = 211/545 (38%), Gaps = 78/545 (14%)
Query: 22 LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
L + L E+A+ ++ + A+ +K L Q +LE + +++ S ME ++A
Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639
Query: 82 FGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK-QLRNVLTNTQSENE 140
+ A+ E R E+L +++ E ++K E EL+ LR++ Q E E
Sbjct: 640 RNALQVD----LAEAEKRREALWEKNTHLEAQ-LQKAEEAGAELQADLRDI----QEEKE 690
Query: 141 RLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQ 200
+ E + + Q +L + K + AR +Q+ L E +L+ +
Sbjct: 691 EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR------ 744
Query: 201 NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKE 260
++ +E + + L QL+ KE+ E L EA + K L +
Sbjct: 745 -----------LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Query: 261 LSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTP 320
+ + + L+ L AE DA A LA+ + KT+
Sbjct: 794 IQTVTQAKEVIQGEVRCLKLE-LDTERSQAEQERDAAA-------RQLAQAEQEGKTALE 845
Query: 321 KKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL 380
+++ + + + + Q+L + L +EREK L L++ Q ++E ++
Sbjct: 846 QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME----AI 901
Query: 381 SEQQEKVTRLTENLSALRRLQASKER----QTALDNEKDRDSHEDGDYYEVDINGPEILA 436
Q+E+ E+ +L+ KER +T L +K
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK---------------------- 939
Query: 437 CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDR 496
E + +QL+ LR + ++ + E G + + L E L++A+RQ R
Sbjct: 940 --------ELADASQQLERLRQDMKVQKLKEQETTGILQTQ---LQEAQRELKEAARQHR 988
Query: 497 ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETP--NRVML 554
+ LA L++E + + Q + + +LV + + V ET NR+
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048
Query: 555 DYYRE 559
+ RE
Sbjct: 1049 ELERE 1053
Score = 62.0 bits (149), Expect = 2e-09
Identities = 160/764 (20%), Positives = 285/764 (37%), Gaps = 114/764 (14%)
Query: 90 KKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQEL 149
+++ + R + LIQ K Q + K ELQ + +L +LT +Q +NE + + L
Sbjct: 254 QELEKEAHERSQELIQ---LKSQGDLEKA-ELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 150 KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLK 209
+E + +E L + EA L ++ +EE +SLQ+ + + Q VE
Sbjct: 310 RETVEILETNHTELME-------HEASLSRN---AQEEKLSLQQVIKDITQVMVE----- 354
Query: 210 HEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL----ETLKTEREQKNSLRKELSHYM 265
E + + + + NS D+ + + ++AL L R+ LR++L+
Sbjct: 355 -EGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413
Query: 266 SINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGL 325
+ H +G + + + L + L + + KE
Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAG-------QTVDLQGEVDSLSKE-- 464
Query: 326 APPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
EL ++L+QQL +E+E L + Q Q + +G EQQE
Sbjct: 465 ------------RELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 386 KV-------TRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACK 438
++ RL E L L Q+ + E SH +G+ + +
Sbjct: 513 ELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572
Query: 439 YHVAVA-----------EAGELREQLKALRSTHEA--------------REAQHAEEKGR 473
++A E +LR L + +EA E ++ R
Sbjct: 573 AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSR 632
Query: 474 YEAEGQALTE-KVSLLEKASRQDR--ELLARLEKELKKVSDVAGETQGSLSVAQDELVTF 530
EA QA +V L E R++ E LE +L+K + E Q L Q+E
Sbjct: 633 MEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 531 SEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGR-RSPILLPKG 589
++L+ H E + ++E + + R E R L
Sbjct: 693 QKKLSESRH-----QQEAATTQLEQLHQEAK---RQEEVLARAVQEKEALVREKAALEVR 744
Query: 590 LLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
L A E R D S L L E ++I + + Q++ V +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKEL---LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 650 ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALA 709
E+ + + +L ++ +A E + L ++E +T L+ K E +
Sbjct: 802 EVIQGEVRCLKLELDTER-SQAEQERDAAARQLAQAEQEG----KTALEQQKAAHEKEVN 856
Query: 710 NLKSKYENEK-------AMVTETMMKLRNELK-ALKEDAATFSSLRAMFATRCDEYITQL 761
L+ K+E E+ A E++ + + EL+ LKE +++A + +E TQ
Sbjct: 857 QLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA----QREEERTQA 912
Query: 762 DE--MQRQLAAAEDEKKTLNSLLRMAIQQKLA-LTQRLELLELD 802
+ Q QL ++ L +LL+ Q++LA +Q+LE L D
Sbjct: 913 ESALCQMQLETEKERVSLLETLLQ--TQKELADASQQLERLRQD 954
Score = 58.2 bits (139), Expect = 3e-08
Identities = 136/590 (23%), Positives = 229/590 (38%), Gaps = 131/590 (22%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLS------HELAETTREKIQAAEYGLAVLEEKHQ--- 56
+E E R V+E P ++ ++L+ EL + + E+ L LE+K Q
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 57 --------LKLQFE-------ELEVDYEAIRSEMEQLKEAFGQAHTNH---KKVAADGES 98
LK Q ELE ++ + + + +KE GQ T + D E
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEE 1599
Query: 99 REESLIQESA------SKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVA----QE 148
R + L +S+ S R++ E E+K R + Q + E L QE
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 149 L---KEINQNVEIQRGR----LRDDIKEYKFR----------EARLLQDYSE-----LEE 186
L KE Q +E QR R L +D+++ K + +L+Q+ +E +
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 187 ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET 246
+ SL+ +LR + E E + I L+E + L QL+ R ++ E L
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHR--KVGETSL------ 1771
Query: 247 LKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
L ++REQ+ + + + L E G
Sbjct: 1772 LLSQREQEIVVLQ-------------------------------------QQLQEAREQG 1794
Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
L + L ++ ++ LA L E E Q+ + Q +++ + L L
Sbjct: 1795 ELKEQSLQSQLDEAQR-ALAQRDQEL------EALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 367 QDTQKQLEHTRGSLSEQQEKVTRLTENLSAL-RRLQASKE-----RQTALDNEK-----D 415
+ L+ G L + +E+ RL E L+ RR+QA +E R + + EK
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907
Query: 416 RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYE 475
+ E +EV+ L + A A E ++L+ALR+ E++ ++H EE R
Sbjct: 1908 QQCAEQAQEHEVETRA---LQDSWLQAQAVLKERDQELEALRA--ESQSSRHQEEAARAR 1962
Query: 476 AEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGET-QGSLSVAQ 524
AE AL E + A+ Q +E + EL + + + T Q SL Q
Sbjct: 1963 AE--ALQEALGKAH-AALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
Score = 52.8 bits (125), Expect = 1e-06
Identities = 122/544 (22%), Positives = 206/544 (37%), Gaps = 128/544 (23%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ---- 56
+ A S E+E A L ++ Q + HE+ TR + AVL+E+ Q
Sbjct: 1892 LRAESREQEKALLALQQQ-----CAEQAQEHEVE--TRALQDSWLQAQAVLKERDQELEA 1944
Query: 57 LKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVR 116
L+ + + EA R+ E L+EA G+AH A + +E+ L++
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAH-------AALQGKEQHLLE----------- 1986
Query: 117 KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREAR 176
Q EL R++ +T + L + +++ + + IQ G ++D Y+ +
Sbjct: 1987 -----QAELS--RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQ 2039
Query: 177 LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS 236
L Q ++ +EE L+H+ +E + L L ++ I
Sbjct: 2040 LQQALAQRDEE--------------------LRHQ----QEREQLLEKSLAQRVQENMIQ 2075
Query: 237 ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
E+Q L ERE++ LH S+ L+ + A+ +
Sbjct: 2076 EKQ------NLGQEREEEE-----------------IRGLHQSVRELQLT--LAQKEQEI 2110
Query: 297 EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQME 356
L + L LP +KTS +++ SL D L E+++L+ L Q E
Sbjct: 2111 LELRETQQRNNLEALPHSHKTSPMEEQ-------SLKLDSLEPRLQRELERLQAALRQTE 2163
Query: 357 REKAGLLATLQDTQKQLEHTRGSLSEQQEKV----TRLTENLSALRRLQASKE-RQTALD 411
+ QD L T+ S+S QE + E S +RLQ E + AL+
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Query: 412 NEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR--STHEAREAQHAE 469
E+ H G + AE G EQ L S EA +
Sbjct: 2224 KER---LHSPG-----------------ATSTAELGSRGEQGVQLGEVSGVEAEPSPDGM 2263
Query: 470 EKGRYEAEGQALTEKV-------SLLEKASRQDRELLARLEKELKKVSDVA--GETQGSL 520
EK + + L + V S L++ + Q R L ++E+E +K+ A GSL
Sbjct: 2264 EKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSL 2323
Query: 521 SVAQ 524
+++
Sbjct: 2324 EISK 2327
Score = 32.0 bits (71), Expect = 2.4
Identities = 28/120 (23%), Positives = 56/120 (46%), Gaps = 13/120 (10%)
Query: 622 REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKS 681
REP + L+A ++ K A +R+ EL +L D +K L + + +L +
Sbjct: 241 REPAQLLLLLAKTQELEKE---AHERSQELI-------QLKSQGDLEKAELQDRVTELSA 290
Query: 682 LLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM---VTETMMKLRNELKALKE 738
LL+ ++Q ++KA ++T E+ N E+E ++ E + L+ +K + +
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 88.6 bits (218), Expect = 2e-17
Identities = 173/858 (20%), Positives = 346/858 (40%), Gaps = 115/858 (13%)
Query: 16 EAQPEWLRAEV---KRLSHELAETT--REKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
+A EWL + K LS L + EK + + L+ LEE H +LQ + E
Sbjct: 350 KATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE-HLSQLQDNPPQEKGEV 408
Query: 71 IRS--EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
+ ++E LK+ N+ ++ A R E L E +E + + + E +QL
Sbjct: 409 LGDVLQLETLKQEAATLAANNTQLQA----RVEMLETERGQQEAKLLAERGHFEEEKQQL 464
Query: 129 RNVLTNTQSENERLASVAQELKEINQ----NVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
+++T+ QS L+ +EL++ +Q + Q L ++ + Q+ + L
Sbjct: 465 SSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL 524
Query: 185 EEENISLQKQVS-VLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
+++ Q Q++ L+Q + +GL+H++++L + QL++ +E + + +
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQ 584
Query: 244 LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
L T ERE R + + + L + L+ +++A + +
Sbjct: 585 LATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQR- 643
Query: 304 EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
E L++ + + + + V++L EL + Q+ + ++ +EK L
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAEL--ELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 364 ATLQDTQKQLEHTRGSLSEQQ-------EKVTRLTENLSALRRLQASKERQTALDNEKDR 416
LQ ++ L+ T+GSL E++ E+ R L A R + ++ + E++R
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 417 DSHE----------DGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKALRSTHEARE 464
+ + E ++ E+ H A +E +L +++ A R +E +
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 465 AQHA--------------EEKGRYEAEGQALTEKVSLLE-----KASRQDREL------L 499
+ A EE + E Q EKV+ +E + SRQ EL L
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL 881
Query: 500 ARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMC--NNETPNRVMLDYY 557
AR +++++ A + LS Q+++ S+E+A L V ET +R ++
Sbjct: 882 ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELV--- 938
Query: 558 REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
P G R P L + + GR S + L
Sbjct: 939 ---------------KEPARAGDRQPEWLEE-----QQGR-----------QFCSTQAAL 967
Query: 618 SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPA---VDKDKEAL 672
RE + N + +R + Q + +A +QE G A + +K A
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 673 MEEILKLKSLLSTKREQITTLRTVL------KANKQTAEVALANLKSKYENEKAMVTETM 726
E ++L++ L+ +R + TL+ L K K L L++ E + +T+
Sbjct: 1028 AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
Query: 727 MKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAED----EKKTLNSLL 782
+L+ +L +++ A+ S ++ A R + +L+ ++ +++ E +++ +SL
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
Query: 783 RMAIQQKLALTQRLELLE 800
R ++ + +R LE
Sbjct: 1148 RSLEAERASRAERDSALE 1165
Score = 88.2 bits (217), Expect = 3e-17
Identities = 170/854 (19%), Positives = 339/854 (39%), Gaps = 148/854 (17%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREK-----------IQAAEYGLAVLEEK 54
+++E A + Q E L + +K+ +L E ++ AAE A L E+
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER 599
Query: 55 HQLKLQFEELEVD----YEAIRSEMEQLKEAFGQAHTN-----HKKVAADGESREESLIQ 105
Q E LE + E ++ +++ EA A T+ +K + E
Sbjct: 600 DAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACV 659
Query: 106 ESASKEQYYVR-KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR 164
E+A +EQ+ + +V EL+ +L+ + T + + + ++L+ + +++++ +G L
Sbjct: 660 ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 165 DDIKEYKFREARLLQDY----SELEEENISL----QKQVSVLRQNQVEFEGLKHEIKRLE 216
++ K R A L++ SEL+ E SL +++ L + + +GL+ +++L
Sbjct: 720 EE----KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG 775
Query: 217 E----ETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFY 272
E ETE L +L +A+ + +E + E+ ++ + RE+ ++E + Y
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY-------- 827
Query: 273 TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
G F + + E K + + + K G+
Sbjct: 828 ---------GAMFQEQLMTLKEECE------------KARQELQEAKEKVAGI------- 859
Query: 333 VSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTE 392
+ SEL IS Q +L ++ A L +Q+ + + + LS QEK+ ++
Sbjct: 860 --ESHSELQISRQQN---ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK 914
Query: 393 NLSALRRL--QASKERQTA---LDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA--- 444
++ L L +A ++++TA L E R ++ E + G + C A+
Sbjct: 915 EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLE-EQQGRQF--CSTQAALQAME 971
Query: 445 -EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLE 503
EA ++ +L+ LR+ + Q EE+G+ E E LT++ + ++ A LE
Sbjct: 972 REAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELE 1031
Query: 504 KELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGG 563
L Q +L+ + E T E LA+ + + + Q
Sbjct: 1032 MRL----------QNALNEQRVEFATLQEALAH---------------ALTEKEGKDQEL 1066
Query: 564 AGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE 623
A E R + K LA + G+G S + G + P+ P+ E
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT---GPKLE 1123
Query: 624 PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
+ R ++ L+ + E + S E A ++++ +E L+ L
Sbjct: 1124 AL---------RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET---LQGQL 1171
Query: 684 STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
K +++ ++ L + A+ LA ++K ++ E ++ + + +
Sbjct: 1172 EEKAQELGHSQSALAS----AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI 1227
Query: 744 SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDH 803
SSL ++ + RQ+ E E K L L+ ++ L +RL LL+
Sbjct: 1228 SSLEE-----------EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ--- 1273
Query: 804 EQTRRGRAKAAPKT 817
+T A+AA ++
Sbjct: 1274 AETASNSARAAERS 1287
Score = 85.1 bits (209), Expect = 2e-16
Identities = 132/525 (25%), Positives = 229/525 (43%), Gaps = 64/525 (12%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
E LR VK+L +LA+ +EK A+ G + + + E EA+R+E+ +L+
Sbjct: 1081 EELRQTVKQLKEQLAK--KEKEHASGSGA-----QSEAAGRTEPTGPKLEALRAEVSKLE 1133
Query: 80 EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE-LQTELKQLRNVLTNTQSE 138
+ +K +S E SL E AS+ + LE LQ +L++ L ++QS
Sbjct: 1134 QQC-------QKQQEQADSLERSLEAERASRAER--DSALETLQGQLEEKAQELGHSQSA 1184
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
LAS +EL V+ + D E+K + AR Q+ SL+++VS+L
Sbjct: 1185 ---LASAQRELAAFRTKVQ-DHSKAED---EWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 199 RQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEI-SERQLEEALETLKTEREQKNSL 257
+ +E EG E+KRL + +LE+ +RL + + A E RE+ SL
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
Query: 258 RKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF--EHGGLAKLPLDN 315
R+E ++ ++ + ++ A E + +A F + L+ L L++
Sbjct: 1298 REEAEKQRVASE-------NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Query: 316 KTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEH 375
TST P+ L L +E +E ++ +++L Q ++ GL A L Q++L
Sbjct: 1351 -TSTQALVSELLPAKHLCQQLQAEQAAAE-KRHREELEQSKQAAGGLRAELLRAQREL-- 1406
Query: 376 TRGSLSEQQEKVTRLTENLSALRRLQASKERQTA-------LDNEKDRDSHEDGD----Y 424
G L ++KV LR +AS Q + L E++R E + +
Sbjct: 1407 --GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQF 1464
Query: 425 YEVDINGPEILACKYHVAVAEAGELR------------EQLKALRSTHEAREAQHAEEKG 472
EV+++ + AV E R +L+ + + +E + + EE+
Sbjct: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524
Query: 473 RYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ 517
R++ E Q LT +V LE R+ + + L K+L SD A + Q
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD-SDQASKVQ 1568
Score = 66.6 bits (161), Expect = 9e-11
Identities = 146/741 (19%), Positives = 290/741 (39%), Gaps = 81/741 (10%)
Query: 90 KKVAADGESREESLIQESASKEQYYVRK---VLELQTELKQLRNVLTNTQSENERLASVA 146
KK AD S + L E A + K + +Q + +L +L Q+ +
Sbjct: 220 KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKEL 278
Query: 147 QELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE 206
+EL++ N+++ ++ ++ K ++++ + ++L EEN L ++ + + +
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338
Query: 207 GLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS---- 262
+E+ EE ++ LE +L E++L AL+ K E+ L+ +LS
Sbjct: 339 DALNELT--EEHSKATQEWLEKQAQL----EKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 263 HYMSINDSFYTSHLHVSLDGLKFSD------DAAEPNNDAEALVNGFEHGG---LAKLPL 313
H + D+ V D L+ A N +A V E AKL
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
Query: 314 DNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK-AGLLATLQDTQKQ 372
+ +K+ L+ SL++DL S +IS + + K++L Q + A L A + +
Sbjct: 453 ERGHFEEEKQQLS----SLITDLQS--SISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 373 LEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE-KDRDSHEDGDYYEVDING 431
L ++ +Q +++ L Q +KE+Q L + ++ G ++V
Sbjct: 507 LTTLNATIQQQDQELAGLK---------QQAKEKQAQLAQTLQQQEQASQGLRHQV---- 553
Query: 432 PEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKA 491
E L+ + E+ E+ +A R H + A AEE+ E A +++ LEK
Sbjct: 554 -EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 492 SRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPN- 550
E+ L+++L+ ++ Q S++ AQ E S ++ L V E
Sbjct: 613 KAAKLEI---LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 551 -----RVMLDYYREGQGGAGR---TSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
+ L E Q + + + + + + + KG L E RA
Sbjct: 670 QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL 729
Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS--QE 660
+ +S+ + E ++ R +++ +A R+ + + Q+
Sbjct: 730 EEQQRC--------ISELKAETRSLVEQHKRERKELEEERA--------GRKGLEARLQQ 773
Query: 661 LGPAVDKDKEALMEEILKLKSLLSTKR---EQITTLRTVLKANKQTAEVALANLKSKYEN 717
LG A + E L E+ + + T EQ+ + + ++ A + ++
Sbjct: 774 LGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE 833
Query: 718 EKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLD-EMQRQLAAAEDEKK 776
+ + E K R EL+ KE A S + +R + +L + R L ++++
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893
Query: 777 TLNSLL--RMAIQQKLALTQR 795
L +Q+K+A T +
Sbjct: 894 RAQKLADDLSTLQEKMAATSK 914
Score = 50.8 bits (120), Expect = 5e-06
Identities = 113/532 (21%), Positives = 208/532 (39%), Gaps = 81/532 (15%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELE 65
E +E RLVM A+ E + +RL AET +AAE A+ EE L+ + E+
Sbjct: 1247 ESKELKRLVM-AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR 1305
Query: 66 VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTEL 125
V E +R E+ E R E L QE + ++ + +K L T
Sbjct: 1306 VASENLRQELTSQAE------------------RAEELGQELKAWQEKFFQKEQALST-- 1345
Query: 126 KQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELE 185
L+ T+TQ+ L +++ R R+++++ K Q L
Sbjct: 1346 --LQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK-------QAAGGLR 1396
Query: 186 EENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALE 245
E + Q+++ E L+ ++ E + L ++ + E L
Sbjct: 1397 AELLRAQRELG-------ELIPLRQKVAEQERTAQQLRAE-----------KASYAEQLS 1438
Query: 246 TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSDDAAEPNNDAEALVNGF 303
LK + + L E + + + L V LD K+ + A DAE
Sbjct: 1439 MLK----KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET----- 1489
Query: 304 EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN--ISEIQKLKQQLMQMEREKAG 361
LA++ + +++ + E + +L E E QKL Q+ Q+E +
Sbjct: 1490 ---RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 362 LLATLQDTQKQLEHTRGSLSEQQEKVTRLT----ENLSALRRLQASKERQTALDNEKDRD 417
+++ K+L + + QQ+K+ + E+ +RLQA A ++K+
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKE-- 1604
Query: 418 SHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAE 477
+ ++Y++ + E Y + EL+EQL++L E + ++ E + E
Sbjct: 1605 --QAAEHYKLQM---EKAKTHYDAKKQQNQELQEQLRSL----EQLQKENKELRAEAERL 1655
Query: 478 GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQ--GSLSVAQDEL 527
G L + ++A + R L A++ +V+ + + G VA D L
Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707
Score = 50.1 bits (118), Expect = 9e-06
Identities = 67/292 (22%), Positives = 116/292 (39%), Gaps = 51/292 (17%)
Query: 7 EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
E A + EAQ EV +E A K++ E EE+ +L Q E+LEV
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGA-----KVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 67 DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
++E+L KK+A + ASK Q Q +LK
Sbjct: 1543 FQREQTKQVEELS----------KKLADS----------DQASKVQ---------QQKLK 1573
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
++ +Q E +RL + EL + Q + + YK + + Y ++
Sbjct: 1574 AVQAQGGESQQEAQRLQAQLNEL-------QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 187 ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALET 246
+N LQ+Q+ L Q Q E + L+ E +RL E + + ++A E + R L + +
Sbjct: 1627 QNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA----EQTCRHLTAQVRS 1682
Query: 247 LKTEREQKNSLRKELSHYMSINDSFYT------SHLHVSLDGLKFSDDAAEP 292
L+ + + ++L + D+ + L +S+D L S + P
Sbjct: 1683 LEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTP 1734
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/171 (23%), Positives = 71/171 (41%), Gaps = 15/171 (8%)
Query: 634 IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
+R+ HLQ D EL+ + + + E + L+ K L K E
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE----- 381
Query: 694 RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATR 753
+L+ E L+ L+ EK V ++ +L+ LK++AAT ++ R
Sbjct: 382 --ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL----QLETLKQEAATLAANNTQLQAR 435
Query: 754 CDEYITQLDEMQRQLAAA----EDEKKTLNSLLRMAIQQKLALTQRLELLE 800
+ T+ + + +L A E+EK+ L+SL+ L+Q E LE
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 86.3 bits (212), Expect = 1e-16
Identities = 178/846 (21%), Positives = 330/846 (39%), Gaps = 123/846 (14%)
Query: 25 EVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQ 84
+V R EL E ++ E V E +++ + ++L + + +++ E F +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 85 AHTNHKKVAADGESREESL------IQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
A ++AA + EE L ++E + Q + ++Q ++ L L +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 139 NERL----ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
++L + ++K++ + + + + IKE K E R+ + S+L EE +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 195 VSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQ- 253
+ + +V L+ +K+ EE+T +LE A R + L++ + L+ + ++
Sbjct: 1026 AKIRNKQEVMISDLEERLKK-EEKTR---QELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 254 KNSLRK---ELSHYMSINDSFYTSHLHVSLDGLK-FSDDAAEPNNDAEALVNGFEHGGLA 309
K L K EL ++ D T H + +L ++ AE D E+
Sbjct: 1082 KLQLAKKEEELQGALARGDD-ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 310 KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDT 369
K L + K E + L E+ +LK+ L E E A +QD
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL---EEETKNHEAQIQDM 1197
Query: 370 QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
+++ LSEQ E+ R NL K +Q + K+
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLE--------KNKQGLETDNKE-------------- 1235
Query: 430 NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE 489
LAC+ V +Q+KA E++H +K +A+ Q L KVS +
Sbjct: 1236 -----LACEVKVL--------QQVKA--------ESEHKRKK--LDAQVQELHAKVSEGD 1272
Query: 490 KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC----MCN 545
+ + E ++L+ EL VS + E A+ + + F+++ A+L + +
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEE-------AEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 546 NETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADG----- 600
ET ++ L R Q + S + E R++ L K +LA ++ AD
Sbjct: 1326 EETRQKLNLSS-RIRQLEEEKNSLQEQQEEEEEARKN---LEKQVLALQSQLADTKKKVD 1381
Query: 601 ---GTGDSSPSPGSSL---PSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQ 654
GT +S L LS E Y+ + +++++ Q D T +L Q
Sbjct: 1382 DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ--QELDDLTVDLDHQ 1439
Query: 655 RIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANL--- 711
R + L K + L EE KS+ + E+ + K+T ++LA
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEE----KSISARYAEERDRAEAEAR-EKETKALSLARALEE 1494
Query: 712 ----KSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQ 767
K ++E + + M L + + ++ + + +E TQL+E++ +
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 768 LAAAEDEKKTLN-SLLRMAIQ--------------QKLALTQRLELLELDHEQTRRGRAK 812
L A ED K L ++ M Q +K L +++ LE + E R+ RA
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 813 AAPKTK 818
A K
Sbjct: 1615 AVASKK 1620
Score = 80.1 bits (196), Expect = 8e-15
Identities = 171/836 (20%), Positives = 334/836 (39%), Gaps = 137/836 (16%)
Query: 5 SEEEEYAR---LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
+EEEE A+ + Q + +RL E E TR++++ A+ L E L+ Q
Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKE--EKTRQELEKAKRKLD--GETTDLQDQI 1071
Query: 62 EELEVDYEAIRSEMEQLKE------AFGQAHTNHK----KVAADGESR----EESLIQES 107
EL+ + ++ ++ + +E A G T HK KV + +++ +E E
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 108 ASKEQYYVRKVLELQTELK----QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRL 163
AS+ + +K +L EL+ +L + L T ++ E QE+ E+ + +E +
Sbjct: 1132 ASRNKAEKQK-RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 164 RDDIKEYKFREARLLQDYSE------------------LEEENISLQKQVSVLRQNQVEF 205
I++ + R A L++ SE LE +N L +V VL+Q + E
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 206 EGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYM 265
E H+ K+L+ + + L++++ + RL+ +L E L+ E + ++L +E
Sbjct: 1251 E---HKRKKLDAQVQELHAKVSEGDRLRV----ELAEKASKLQNELDNVSTLLEEAEK-- 1301
Query: 266 SINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGL 325
G+KF+ DAA + + + KL L ++ ++E
Sbjct: 1302 ---------------KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE-- 1344
Query: 326 APPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQE 385
+ L E E + K +E++ L + L DT+K+++ G++ +E
Sbjct: 1345 --------KNSLQEQQEEEEEARKN----LEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 386 KVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
+L ++ AL +RL+ L+ K+R E D VD++ +A
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL-TVDLDHQRQVASNLEKKQK 1451
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
+ +L + K++ A++AEE+ R EAE + K L +A LE+
Sbjct: 1452 KFDQLLAEEKSI-------SARYAEERDRAEAEAREKETKALSLARA----------LEE 1494
Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
L+ + + + L ++L++ +++ H + E R + E +
Sbjct: 1495 ALEAKEEFERQNK-QLRADMEDLMSSKDDVGKNVHEL-----EKSKRALEQQVEEMRTQL 1548
Query: 565 GRTSPGGRTSPEARGRRSPILLPKGLLAPEAG-RADGGTGDSSPSPGSSLPSPLSDPRRE 623
+ + +A+ R L + A +A D T D L
Sbjct: 1549 EELEDELQATEDAKLR-----LEVNMQAMKAQFERDLQTRDEQNEEKKRL---------- 1593
Query: 624 PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
+ Q++ L+A ++ + +AS++ KD EA +E K + +
Sbjct: 1594 ----------LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 684 STKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF 743
+Q+ L+ +K ++ E A A+ + K + + L E+ L+E+ A+
Sbjct: 1644 I---KQLRKLQAQMKDYQRELEEARASRDEIFAQSKES-EKKLKSLEAEILQLQEELASS 1699
Query: 744 SSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELL 799
R DE ++ +A DEK+ L + + ++ +ELL
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 78.2 bits (191), Expect = 3e-14
Identities = 184/833 (22%), Positives = 323/833 (38%), Gaps = 101/833 (12%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELE 65
E E+ +R E Q L E++ L EL +T E +E +LK EE
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 66 VDYEAIRSEM--------EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRK 117
++EA +M E+L E QA K+ A+ E ++ L E+ +K
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQA----KRFKANLEKNKQGL--ETDNK------- 1234
Query: 118 VLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-RLRDDIKEYKFREAR 176
EL E+K L+ V ++ + ++L + QEL + ++ G RLR ++ E +
Sbjct: 1235 --ELACEVKVLQQVKAESEHKRKKLDAQVQEL-----HAKVSEGDRLRVELAEKASKLQN 1287
Query: 177 LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS 236
L + S L EE +K+ ++ E +L++ E L + + L
Sbjct: 1288 ELDNVSTLLEE---AEKKGIKFAKDAASLE------SQLQDTQELLQEETRQKLNLSS-R 1337
Query: 237 ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN--- 293
RQLEE +L+ ++E++ RK L + S D L + E
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 294 -NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQ 351
DAEAL E LA L+ K L L DL + + S ++K +++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEK-----TKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 352 LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE------ 405
Q+ E+ + A + + + E +E +EK T+ AL +KE
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAE------AEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 406 RQTALDNEKDRDSHED--GDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR 463
+Q D E S +D + +E++ L + + EL ++L+A
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELE-KSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 464 EAQHAEEKGRYEAEGQALTEKVSLLEK-ASRQDRELLARLEKELK-KVSDVAGETQGSLS 521
E K ++E + Q E+ ++ +Q REL A LE E K + VA + + +
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 522 VAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYRE-GQGGAGRTSPGGRTSPEARGR 580
+ E E AN + M DY RE + A R ++ +
Sbjct: 1626 LKDLEA---QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 581 RS----PILLPKGLLAPEAGRADG-----GTGDSSPSPGSSLPSPLSDPRREPMNIYNLI 631
+S + L + L + E R D + S + L + RR I L
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 632 AIIRDQIKHLQAAVDR-----------TTELSRQRIASQELGPAVDKDKEALMEEILKLK 680
+ ++ +++ DR EL+ +R A+Q+ D ++ L + +LK
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK----SDNARQQLERQNKELK 1798
Query: 681 SLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDA 740
+ L +E +++ KA E + L+ + E E +R K LKE
Sbjct: 1799 AKL---QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855
Query: 741 ATFSSLRA---MFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
R + + ++ ++ +++RQL AE+E N+ R +Q++L
Sbjct: 1856 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA-SRRKLQREL 1907
Score = 74.7 bits (182), Expect = 3e-13
Identities = 89/435 (20%), Positives = 190/435 (43%), Gaps = 37/435 (8%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSE 74
+EA+ E+ R K+L ++ + K + + + K L+ Q EE+ E + E
Sbjct: 1496 LEAKEEFERQN-KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 75 MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTN 134
++ ++A + N + + A E ++ +++ K++ +++V EL+ EL+ R
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 135 TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
+ +++ +LK++ +E + IK+ + +A++ ELEE S +
Sbjct: 1615 AVASKKKMEI---DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 195 VSVLRQNQVEFEGLKHEIKRLEEE----------TEYLNSQLEDAIRLKEISERQLEEAL 244
+ ++++ + + L+ EI +L+EE E +L D I + L +
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 245 ETLKTEREQ-KNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDD--AAEPNNDAEALVN 301
L+ Q + L +E S+ +ND F + L V + + + AA+ +++A
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR---- 1787
Query: 302 GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
+L NK K + L S +S L ++I +L++QL Q +E+A
Sbjct: 1788 -------QQLERQNKELKAKLQELEGAVKSKFKATISALE-AKIGQLEEQLEQEAKERAA 1839
Query: 362 LLATLQDTQK-------QLEHTRGSLSEQQEKVTRLTENLSALRR-LQASKERQTALDNE 413
++ T+K Q+E R + +E++ + + L+R L+ ++E T +
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 414 KDRDSHEDGDYYEVD 428
+ + E D E +
Sbjct: 1900 RRKLQRELDDATEAN 1914
Score = 55.1 bits (131), Expect = 3e-07
Identities = 65/266 (24%), Positives = 115/266 (43%), Gaps = 53/266 (19%)
Query: 22 LRAEVKRLSHELAETTREKIQA--------------AEYGLAVLEEKHQLKLQFEELEVD 67
L AE+ +L ELA + R + A A A+L+EK +L+ + +LE +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 68 YEAIRSEMEQLKEAFG----QAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
E +S ME L + F Q T + ++AA E S Q+S + Q R+ EL+
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAA-----ERSAAQKSDNARQQLERQNKELKA 1799
Query: 124 ELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSE 183
+L++L +V + K +E + G+L E +L Q+ E
Sbjct: 1800 KLQELEG-------------AVKSKFKATISALEAKIGQL----------EEQLEQEAKE 1836
Query: 184 LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
N +++ L++ ++ E + + +E+ E N+ R+K++ +RQLEEA
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA------RMKQL-KRQLEEA 1889
Query: 244 LETLKTEREQKNSLRKELSHYMSIND 269
E + L++EL N+
Sbjct: 1890 EEEATRANASRRKLQRELDDATEANE 1915
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 85.1 bits (209), Expect = 2e-16
Identities = 181/864 (20%), Positives = 336/864 (38%), Gaps = 123/864 (14%)
Query: 15 MEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ---------------LKL 59
+EA+ W + + +++ +T E A + L+ +H+ LK
Sbjct: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 60 QFEELEVDY----EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYV 115
E+++ D+ + + S +E+ K+ N K++ + S +QE K +
Sbjct: 781 NIEQMDTDHKETKDVLSSSLEEQKQL--TQLINKKEIFIEKLKERSSKLQEELDKYSQAL 838
Query: 116 RKVLELQTELKQLRNVLTNTQSENERLASVAQELK-EINQNVEIQRGRLRDDIKEYKFRE 174
RK L+ +++ L + + EN L + L+ E ++ + + D + E
Sbjct: 839 RKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV 898
Query: 175 ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE 234
++L LEEE QK + Q++++ E K+ +E Y + Q+ +A +
Sbjct: 899 SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM-NATHTQL 957
Query: 235 ISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNN 294
E+ EE KT + K L +E + N + SL+
Sbjct: 958 FLEKD-EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLN------------- 1003
Query: 295 DAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQ 354
+ NG E L+K + K+ L LL+E NIS L +Q+ Q
Sbjct: 1004 ----IENGSEKHDLSKAETERLVKGIKER-------ELEIKLLNEKNIS----LTKQIDQ 1048
Query: 355 MEREKAGLLATL---QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALD 411
+ +++ G L + +D + Q H R S + + V L + L A +E+ A+
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQA---YAMEREKVFAVL 1105
Query: 412 NEKDRD-SHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEE 470
NEK R+ SH +Y+++ +I+A K + E ++ S+ + + +
Sbjct: 1106 NEKTRENSHLKTEYHKM----MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQN 1161
Query: 471 KGRY----EAEGQALTEKVSLLEKA--------------SRQDRELLA---RLEKELKKV 509
R + E AL++K L S Q ELL +L++++KK+
Sbjct: 1162 LSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM 1221
Query: 510 SDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDY------YRE---- 559
+ + ++ Q E EEL L V + +++ +++ +DY Y +
Sbjct: 1222 EEWKQQVMTTVQNMQHESAQLQEELHQLQAQV-LVDSDNNSKLQVDYTGLIQSYEQNETK 1280
Query: 560 ----GQGGAGRTSPGGR---TSPEARGRR---SPILLPKGLLAPEAGRADGGTGDSSPSP 609
GQ A G+ T G+ SP L LL P++ + S
Sbjct: 1281 LKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSE 1340
Query: 610 GSS-LPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKD 668
S L L + R+ I +++ L ++ T+EL R+ + K+
Sbjct: 1341 SSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKE 1400
Query: 669 KEALMEEILKLKSLL-STKREQITTLRT--VLKANK-QTAEVALANLK----------SK 714
K+ +++++LK K LL K +Q+ + K N+ + A+ NLK K
Sbjct: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGK 1460
Query: 715 YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDE 774
+ E + ET E +AL+E FS + C + ++ L E
Sbjct: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
Query: 775 KK-TLNSLLR--MAIQQKLALTQR 795
K LN LL ++Q+K + Q+
Sbjct: 1521 KTGELNQLLNAVKSMQEKTVVFQQ 1544
Score = 62.0 bits (149), Expect = 2e-09
Identities = 107/505 (21%), Positives = 209/505 (41%), Gaps = 58/505 (11%)
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
QFEEL + + ++ ++++++E Q T + + E + +QE + Q V
Sbjct: 1203 QFEELLQERDKLKQQVKKMEEWKQQVMTTVQNM-----QHESAQLQEELHQLQAQVLVDS 1257
Query: 120 ELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNV-------EIQRGRLRDDIKEYK 171
+ ++L+ L + +NE +L + QEL ++ ++ ++ G+L DI +
Sbjct: 1258 DNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKL--DIISPQ 1315
Query: 172 FREARLLQDYSE----------LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY 221
A LL S L E + LQ+++ LR++ E + I+ L+E
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDAT---IRTLQENNHR 1372
Query: 222 LNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSI-NDSFYTSHLHVSL 280
L+ + L+ Q + ++ LK +++ L KE + +D +S+ +
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN--- 1429
Query: 281 DGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL 340
F++ E +A+ N E + ++ + +K L E
Sbjct: 1430 ----FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQET 1485
Query: 341 NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE--------QQEKVTRLTE 392
N+ L+++ + K LA Q +++ + G L++ Q++ V E
Sbjct: 1486 NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQE 1545
Query: 393 NLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ 452
+ L+ + TAL NE R D ++ + E+ + H+ +E RE
Sbjct: 1546 RDQVMLALKQKQMENTALQNEVQR--LRDKEFR----SNQELERLRNHLLESEDSYTREA 1599
Query: 453 LKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV 512
L A E REA+ ++ E + L + +E AS Q + L+++L VS
Sbjct: 1600 LAA-----EDREAKLRKKVTVLE---EKLVSSSNAMENASHQASVQVESLQEQLNVVSKQ 1651
Query: 513 AGETQGSLSVAQDELVTFSEELANL 537
ET LSV+Q+++ ++ LANL
Sbjct: 1652 RDETALQLSVSQEQVKQYALSLANL 1676
Score = 56.6 bits (135), Expect = 9e-08
Identities = 135/770 (17%), Positives = 301/770 (39%), Gaps = 98/770 (12%)
Query: 9 EYARLVMEAQPEWLRAEVKRLSHELAETTRE--KIQAAEYGLA-VLEEKHQLKLQFEELE 65
E R ++ + E L E +++ E E K+Q + + + EK ++ Q +E
Sbjct: 326 ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385
Query: 66 VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTEL 125
+ ++ + E + N A+ + + I+ ++ ++ ELQ L
Sbjct: 386 EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSL 445
Query: 126 KQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELE 185
+L N +S R S+ EL ++ N+E + L I E + L+ + EL+
Sbjct: 446 LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE----KETLIAEIEELD 501
Query: 186 EENISLQKQVSVLR------QNQVE--FEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE 237
+N K + +++ QN+ + LK ++ ++ L D + ++ +
Sbjct: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561
Query: 238 RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAE 297
+L ++ L K L ++ + + + S++ + + L+ + + +
Sbjct: 562 EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621
Query: 298 ALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQL----- 352
+ N L+ +++ K+ L + V +L + N+SE+++L + L
Sbjct: 622 RIRNELMQS------LNQDSNSNFKDTLLKEREAEVRNL--KQNLSELEQLNENLKKVAF 673
Query: 353 -MQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-----RLQASKER 406
++ME EK L+ +D + QLE ++ + + E L + L +K+R
Sbjct: 674 DVKMENEK--LVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR 731
Query: 407 QTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE-QLKALRSTHEAREA 465
N+ ++ E + ++ + ++ H + + + ++ ++ L+ E +
Sbjct: 732 LLEEANKYEKTIEELSNARNLNTSALQL----EHEHLIKLNQKKDMEIAELKKNIEQMDT 787
Query: 466 QHAEEKGRYEA---EGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSV 522
H E K + E + LT+ ++ E + +E ++L++EL K S + + +
Sbjct: 788 DHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNE----I 843
Query: 523 AQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRS 582
+ + L ++ NN L+ RE Q R +
Sbjct: 844 LRQTIEEKDRSLGSMKEE----NNHLQEE--LERLREEQ-----------------SRTA 880
Query: 583 PILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQ----I 638
P+ PK L DS S + + I + II DQ +
Sbjct: 881 PVADPKTL-------------DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927
Query: 639 KHLQAAVDRTTELSRQRIASQELGPA-----VDKDKE--ALMEEILKLKSLLSTKREQIT 691
+ LQ+ ++ E+ R +++ ++KD+E +L + I ++K+ L +R+ I
Sbjct: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987
Query: 692 TLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRN---ELKALKE 738
T + + + + + N K++ KA + ++ E+K L E
Sbjct: 988 TDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE 1037
Score = 54.3 bits (129), Expect = 5e-07
Identities = 46/228 (20%), Positives = 114/228 (50%), Gaps = 21/228 (9%)
Query: 52 EEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHT------NHKKVAADGESREESLIQ 105
+E+ Q+ L ++ +++ A+++E+++L++ +++ NH + D +RE +
Sbjct: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
Query: 106 ESASKEQYYVRKVLELQTELKQLRNVLTNTQSE-NERLASVAQELKEINQNVE---IQRG 161
+ +K + +KV L+ +L N + N + + ++ S+ ++L +++ + +Q
Sbjct: 1604 DREAKLR---KKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLS 1660
Query: 162 RLRDDIKEYKFREARLLQDYSELEEE-----NISLQKQVSVLRQNQVEFEGLKHEIKRLE 216
++ +K+Y A L ++E + L+KQ ++ + + E L+ ++ L+
Sbjct: 1661 VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720
Query: 217 EETEYLNSQLEDAIRLKE---ISERQLEEALETLKTEREQKNSLRKEL 261
E + N+ L+ A RL E + E Q+EE + +E + ++K+L
Sbjct: 1721 ECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768
Score = 52.0 bits (123), Expect = 2e-06
Identities = 79/428 (18%), Positives = 178/428 (41%), Gaps = 51/428 (11%)
Query: 11 ARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
A L+ E LRA + E +E +++++ +L+ +E +
Sbjct: 1319 ASLLTPQSAECLRASKSEVLSESSELLQQELE-------------ELRKSLQEKDATIRT 1365
Query: 71 IRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRN 130
++ +L ++ +K +S + L ++ ++ K L ++ + QL +
Sbjct: 1366 LQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLS 1425
Query: 131 V---LTNTQSENERLASVAQELKEINQNVEIQRGRLRDD----IKEYKFREARLLQDYSE 183
TN +ENE L LKE +E+ G+L+ + ++ Y+ +E +Y
Sbjct: 1426 SNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKET----EYQA 1481
Query: 184 LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE--------ETEYLNSQLEDAIRLKE- 234
L+E N+ +LR+ + E +K + E+ +T LN L ++E
Sbjct: 1482 LQETNMKFSM---MLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538
Query: 235 --ISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEP 292
+ +++ ++ + LK ++ + +L+ E+ + D + S+ L+ L+ +E
Sbjct: 1539 TVVFQQERDQVMLALKQKQMENTALQNEVQR---LRDKEFRSNQE--LERLRNHLLESED 1593
Query: 293 NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQL 352
+ EAL L K T +E L S ++ + S +++ L++QL
Sbjct: 1594 SYTREALAAEDREAKL------RKKVTVLEEKLVSSSNAMEN--ASHQASVQVESLQEQL 1645
Query: 353 MQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
+ +++ L +Q+Q++ SL+ Q + + A+ + K++Q +
Sbjct: 1646 NVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW 1705
Query: 413 EKDRDSHE 420
+K+ ++ E
Sbjct: 1706 KKNAENLE 1713
Score = 51.2 bits (121), Expect = 4e-06
Identities = 151/794 (19%), Positives = 305/794 (38%), Gaps = 96/794 (12%)
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLE 120
F + ++D+ I S +++ + +V + S Q + + +Q + K+
Sbjct: 157 FHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQN 216
Query: 121 LQTELKQLRNV-LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR----EA 175
+ ELKQ R+ + + Q E L + Q+ + EI R R R+++ +Y+ R E
Sbjct: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQ-----KLTEISR-RHREELSDYEERIEELEN 270
Query: 176 RLLQDYSELEEENIS----LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
L Q S + E ++S +QK + VL+ +VE ++++LE++ + +N +L A
Sbjct: 271 LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVEST---KKMEQLEDKIKDINKKLSSAEN 327
Query: 232 LKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
++I R+ E+ + E+ +L+ E S + +K SD E
Sbjct: 328 DRDILRREQEQLNVEKRQIMEECENLKLECS--------------KLQPSAVKQSDTMTE 373
Query: 292 PNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQ 351
+ E L + D + + L + +L ++ I ++K K
Sbjct: 374 KERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL 433
Query: 352 LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSA----LRRLQASKERQ 407
L Q + E L L + + ++ T ++ L NL A L + + KE
Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493
Query: 408 TALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQH 467
A E DR + E A K+ + + + +L +Q S +
Sbjct: 494 IAEIEELDRQNQE---------------ATKHMILIKD--QLSKQQNEGDSIISKLKQDL 536
Query: 468 AEEKGR---YEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
+EK R E + +T+++ + ++ Q L L +K+ D L+ +Q
Sbjct: 537 NDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQ 596
Query: 525 DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
+ V+ +E L H+ N E +R+ E + S + R + +
Sbjct: 597 ESNVSIQKENLELKEHIRQ-NEEELSRIR----NELMQSLNQDSNSNFKDTLLKEREAEV 651
Query: 585 LLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHL--- 641
K L+ +L D + E + +R Q++
Sbjct: 652 RNLKQNLS------------ELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699
Query: 642 --QAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKA 699
Q ++++ T + ++ E+ + K+ L+EE K + + E+++ R + +
Sbjct: 700 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI----EELSNARNLNTS 755
Query: 700 NKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR-----AMFATRC 754
Q L L K + E A + + + ++ + K K+ SSL +
Sbjct: 756 ALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKD--VLSSSLEEQKQLTQLINKK 813
Query: 755 DEYITQLDEMQRQLAAAEDEKKTL---NSLLRMAIQQK----LALTQRLELLELDHEQTR 807
+ +I +L E +L D+ N +LR I++K ++ + L+ + E+ R
Sbjct: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
Query: 808 RGRAKAAPKTKPAT 821
+++ AP P T
Sbjct: 874 EEQSRTAPVADPKT 887
Score = 49.7 bits (117), Expect = 1e-05
Identities = 52/261 (19%), Positives = 120/261 (45%), Gaps = 14/261 (5%)
Query: 7 EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ-LKLQFEELE 65
EEE +R+ E + L + +++ + L+ LE+ ++ LK +++
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
Query: 66 VDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQ---YYVRKVLELQ 122
++ E + E ++ + + +++ + + E+L E E + +++LE
Sbjct: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
Query: 123 TELKQLRNVLTNTQSENERLASVAQE-LKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
+ ++ L+N ++ N + E L ++NQ +++ L+ +I++
Sbjct: 737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVL 796
Query: 182 SELEEENISLQKQVS-VLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
S EE QKQ++ ++ + ++ E LK +L+EE + + A+R EI + +
Sbjct: 797 SSSLEE----QKQLTQLINKKEIFIEKLKERSSKLQEELD----KYSQALRKNEILRQTI 848
Query: 241 EEALETLKTEREQKNSLRKEL 261
EE +L + +E+ N L++EL
Sbjct: 849 EEKDRSLGSMKEENNHLQEEL 869
Score = 47.0 bits (110), Expect = 7e-05
Identities = 137/770 (17%), Positives = 288/770 (37%), Gaps = 149/770 (19%)
Query: 83 GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142
GQ K + +G E+ + +S +KE + +L +SENERL
Sbjct: 28 GQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAIL----------------RSENERL 71
Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV------- 195
+ +L+E ++ EIQ ++ Y+ + + + S L+ I+LQ Q+
Sbjct: 72 KKLCTDLEEKHEASEIQ---IKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAA 128
Query: 196 --------------------------SVLRQNQVEFEGL---KHEIKRLEEETEYLNSQL 226
S + ++F + + EI RL E L S++
Sbjct: 129 QSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEV 188
Query: 227 EDAIRLKEISERQ------------LEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
+ + S+ Q L+ ++ LK R Q+ + H MS+ + +
Sbjct: 189 GHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEID---DHQHEMSVLQNAHQQ 245
Query: 275 HLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVS 334
L + + ++ ++ E L N + GG G+ S +
Sbjct: 246 KL--TEISRRHREELSDYEERIEELENLLQQGG---------------SGVIETDLSKIY 288
Query: 335 DLLSELNISEIQKLK-----QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTR 389
++ + + +I+K++ +QL ++ L++ ++ + L + L+ ++ ++
Sbjct: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIME 348
Query: 390 LTENLS-ALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGE 448
ENL +LQ S +Q+ EK+R + EV + A+++A
Sbjct: 349 ECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV---------FRLQQALSDAEN 399
Query: 449 LREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKK 508
+L +L + AE+ + + + L ++ SLL + + + L +L E +
Sbjct: 400 EIMRLSSLNQDNSL-----AEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454
Query: 509 VSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTS 568
+ A ++ EL H N E + + E +
Sbjct: 455 IKSTATRD-----------ISLDSEL-----HDLRLNLEAKEQELNQSISEKETLIAEIE 498
Query: 569 PGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRR------ 622
R + EA ++L K L+ + D S S L L+D ++
Sbjct: 499 ELDRQNQEA---TKHMILIKDQLSKQQNEGD--------SIISKLKQDLNDEKKRVHQLE 547
Query: 623 -EPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIAS--QELGPAVDKDKE---ALMEEI 676
+ M+I + + ++++ + A++ L++Q++ + L ++K +E ++ +E
Sbjct: 548 DDKMDITKELDVQKEKLIQSEVALN-DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN 606
Query: 677 LKLKSLLSTKREQITTLRTVL--KANKQTAEVALANLKSKYENEKAMVTETMMKLRNELK 734
L+LK + E+++ +R L N+ + L + E E + + + +L +
Sbjct: 607 LELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE 666
Query: 735 ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRM 784
LK+ A C++ QL+E EK T+ L+M
Sbjct: 667 NLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKM 716
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 83.2 bits (204), Expect = 9e-16
Identities = 174/820 (21%), Positives = 312/820 (38%), Gaps = 116/820 (14%)
Query: 13 LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR 72
L ME + + L +V+ L +E+ + + +++EK QL+ E L + E
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 73 SEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVL 132
+EQ E Q ++ R+ S I A +V +++ E K L +
Sbjct: 554 KILEQENEHLNQTVSS---------LRQRSQISAEA--------RVKDIEKENKILHESI 596
Query: 133 TNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
T S +L+ + E ++I + +E KE R L + LE+EN LQ
Sbjct: 597 KETSS---KLSKIEFEKRQIKKELE--------HYKEKGERAEELENELHHLEKENELLQ 645
Query: 193 KQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTERE 252
K+++ L+ + E L+ E LE E L L+ S + L LE+L+ E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLD--------SFKNLTFQLESLEKENS 697
Query: 253 QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE-----HGG 307
Q + EL + + L+ + + + E L F+
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 308 LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLS--------ELNISEIQKLKQQLMQMEREK 359
L ++N+ E L S+L + N+ E++ ++L Q+E+E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 360 AGL---LATLQDTQKQLEHTRGSLSEQQE-KVTRLTENLSALRRLQASKERQTALDNEKD 415
L + L+ +KQLE L +Q E K T L EN + L+ KE +T
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE--KENKTL------ 869
Query: 416 RDSHEDGDYYEVDINGPEI------LACKYHVAVAEAGELREQLKALRSTHEAREAQHAE 469
S E G Y E + E+ L + + + LRE L + + ++ +
Sbjct: 870 --SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDL 925
Query: 470 EKGRYEAEGQALTEKVSLLEKASRQDRELL--ARLEKELKKVSDVAGETQGSLSVAQDEL 527
EK +E E L ++ L ++ S DR L ++LE LKK ++ E +L +E
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Query: 528 VTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLP 587
++++L + V +Y Q R E + SP
Sbjct: 986 TNYNQQL-----------RQELKTVKKNYEALKQ----------RQDEERMVQSSP---- 1020
Query: 588 KGLLAPEAGRADGGTGDSSPSPGSSL--PSPLSDPRREPMNIYNLIAIIRDQIKHLQAAV 645
P +G + +S + L L + R + ++ Q+K L+
Sbjct: 1021 -----PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET-- 1073
Query: 646 DRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAE 705
+ L Q +A Q ++ + L + KL+ ST Q T+L Q A+
Sbjct: 1074 -QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM------NQNAQ 1126
Query: 706 VALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQ 765
+ + +S ENE V + L++ +L +D L A+ + I++ ++
Sbjct: 1127 LLIQ--QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK 1184
Query: 766 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
E E + L ++QK L ++L+++ E+
Sbjct: 1185 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
Score = 80.5 bits (197), Expect = 6e-15
Identities = 163/851 (19%), Positives = 328/851 (38%), Gaps = 88/851 (10%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLKLQFEEL 64
E E ++E + E L V L + +++ E +L E + + ++
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 65 EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV------ 118
E + I+ E+E KE +A ++ +E L+Q+ + + K+
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 119 -LELQTELKQLRNVLTNTQSENERLASVAQELKEINQ-NVEIQRGRLRDDIKEYKFREAR 176
EL+ E ++L+ L + ++ +L S+ +E ++++ N+E++R + +K + A+
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV--ESLKCASMKMAQ 722
Query: 177 LLQDYSELEEENISLQKQVSVLRQN-------QVEFEGLKHEIKRLEEETEYLNS---QL 226
L + ELE E L+K + +L+ + +V ++GL E +RL++ E N QL
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 227 EDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
E ++ E+ + L++ LE LK ++ L KE N S + D +
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKE-------NKSLEQETSQLEKDKKQLE 835
Query: 287 DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE-GLAPPSPSLVSDLLSELNISEI 345
+ AE E + L+ + T KE G+ S + + E+
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC---------VRLKEL 886
Query: 346 QKLKQQLMQMEREKAGLLATLQDT-------QKQLEHTRGSLSEQQEKVTRLTENLSALR 398
+K ++L++ L TL++ +Q+ + L+ + EK+ E L L
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL--LH 944
Query: 399 RLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRS 458
Q++ +R L+++ + + + E I L + + +LR++LK ++
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA---LEARLEESTNYNQQLRQELKTVKK 1001
Query: 459 THEAREAQHAEEK------------GRYEAEGQALTEKV----SLLEKASRQDRELLAR- 501
+EA + + EE+ ++E E Q T ++ L + R + L A
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 502 --LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANL--YHHVCMCNNETPNRVMLDYY 557
L+ +LK++ Q + Q + V+ E+ L + N T N
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 558 REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
+ + S + R + L + + + + S SL S
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-LLHERQASEYESLISKH 1180
Query: 618 SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEIL 677
+ N+ + D+ L + +L + QE +K+ E + E
Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1240
Query: 678 KLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALK 737
K L + +++ + L + + NLKS N K T +L E LK
Sbjct: 1241 K----LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT----RLEAEFSKLK 1292
Query: 738 EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE 797
E +C+ L +++ L E+ + L+ + + +Q + L Q +E
Sbjct: 1293 EQYQQLDITSTKLNNQCE----LLSQLKGNL--EEENRHLLDQIQTLMLQNRTLLEQNME 1346
Query: 798 LLELDHEQTRR 808
+L H + R+
Sbjct: 1347 SKDLFHVEQRQ 1357
Score = 77.0 bits (188), Expect = 7e-14
Identities = 177/886 (19%), Positives = 333/886 (37%), Gaps = 187/886 (21%)
Query: 25 EVKRLSHELAETTR---EKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
E K + + E TR +K+ E +E QLK + ++E++ + R ++E+L E
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELE------KENLQLKAKLHDMEMERDMDRKKIEELME- 410
Query: 82 FGQAHTNHKKVAADGESREESL--------------IQESASK------EQYYVRKVLEL 121
N A +S +ESL + E+ K + ++L+L
Sbjct: 411 -----ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 122 QTE-------LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
+ E +++LR + + + ++ + +E + +++ VEI L ++I + K
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI----LENEIVQEKQSL 521
Query: 175 ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLN---------SQ 225
+L +E L+K + LR+N + +IK LE+E E+LN SQ
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENS------ERQIKILEQENEHLNQTVSSLRQRSQ 575
Query: 226 LEDAIRLKEISE------RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
+ R+K+I + ++E L +K ++KEL HY
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY--------------- 620
Query: 280 LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
E AE L N H L +N+ K L +
Sbjct: 621 ----------KEKGERAEELENELHH-----LEKENELLQKKITNL-------------K 652
Query: 340 LNISEIQKLKQQLMQMEREKAGLLATLQDTQ------KQLEHTRGSLSEQQEKVTRLTEN 393
+ +I+ L+Q+ ++ERE L TL + + LE L E+ ++ R E+
Sbjct: 653 ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 394 L--SALRRLQASKERQTALDNEKD---------RDSHEDGDYYEVDINGPEILACKYHVA 442
L ++++ Q E + L++EK+ + S + + EV G +I +
Sbjct: 713 LKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 443 VAEAG----ELREQLKALRSTHEAREAQHAEEK------GRYEAEGQALTEKVSLLEKAS 492
+ + +L +L+ L ++ + E K + E E ++L ++ S LEK
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMC-------N 545
+Q + RL ++ + E + + E T S+E+ +Y C+ N
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-GIYKESCVRLKELEKEN 890
Query: 546 NETPNRVMLDYYREGQGGAGRTSPGGRTSPEARG--RRSPILLPKGLLAPEAGRADGGTG 603
E R +D S +T + + L GL + T
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 604 DSSPSPGSSLPSPLS-------------DPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
D S L S L + R E YN Q++ V + E
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN------QQLRQELKTVKKNYE 1004
Query: 651 LSRQRIASQEL---GPAV-------DKDKEALMEEILKLKS-LLSTKREQITTLRTVLKA 699
+QR + + P + +++ + E+LK+K L+ +R T L+A
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT-----LQA 1059
Query: 700 NKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYIT 759
KQ + L L+++ N +A + + L+ + +L+E T + A +
Sbjct: 1060 EKQALKTQLKQLETQNNNLQAQI----LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115
Query: 760 QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
Q + Q A ++ +L + I+++ L + L DHE+
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
Score = 74.3 bits (181), Expect = 4e-13
Identities = 156/773 (20%), Positives = 307/773 (39%), Gaps = 101/773 (13%)
Query: 94 ADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEIN 153
AD +++ L QE K + ++L+ + EL+Q+ L Q EN L S A+ +
Sbjct: 254 ADAKAKIRRLRQELEEKTE----QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 154 QNVEIQR------GRLRDDIKEYK-------FREARLLQDYSELEEENISLQKQVSVLRQ 200
++ R +L ++ YK F +AR+ EL+E+N L + ++L
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARV----EELKEDNQVLLETKTMLED 365
Query: 201 NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL-ETLKTEREQKNSLRK 259
++ LE+E L ++L D +++ +++EE + E + E QK S+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE-PNNDAEALVNGFEHGGLAKLPLDNKTS 318
L HL L+ + + + +E P VN L KL ++N++
Sbjct: 426 SL-------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 319 TPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQLMQMEREKAGLLATLQDTQK------ 371
T E L S+ + L + E Q+L +++ +E E +LQ+ Q
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 372 ----QLEHTRGSLSEQQEKVTR--------LTENLSALR-RLQASKERQTALDNEKDRDS 418
QLE T +L E E+ + L + +S+LR R Q S E + ++++
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 419 HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
HE ++ E E +++++L+ + E R + E E E
Sbjct: 593 HESIKETSSKLSKIEF----------EKRQIKKELEHYKEKGE-RAEELENELHHLEKEN 641
Query: 479 QALTEKVSLLE------KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE 532
+ L +K++ L+ +A Q+ L R ++LKK D L + E E
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 533 ELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
E L +V C + ++ L+ +E + + G + + + +
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
L E R T ++S L S L D E ++ ++ L+ + R +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQT-------LQKNLEELKISSKRLEQ 812
Query: 651 LSRQRIASQELGPAVDKDKEALMEEILKLKSLL----STKREQITTLRTVLKANKQTA-- 704
L ++ + ++ ++KDK+ L +E +L+ +T E + + K NK +
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 705 ----EVALANLKSKYENEKAMV------TETMMKLRNELKALKEDAATFSSLRAMFATRC 754
+ + LK + K +V +T++ LR +L + K ++
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 755 DEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL-TQRLELLELDHEQT 806
++ + + + +D K L S L +++ L + +++ LE E++
Sbjct: 933 EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/260 (23%), Positives = 112/260 (43%), Gaps = 36/260 (13%)
Query: 31 HELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQA----- 85
HE E E+ QA+EY +++ + LK + LEV++ + QL + GQ
Sbjct: 1159 HEKLELLHER-QASEYE-SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
Query: 86 ------------HTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRN 130
+ NH+ VAA+ + L E+ Y + + E LQT+ K L++
Sbjct: 1217 MLKVEQEKMLLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272
Query: 131 VLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
+L N++ E RL + +LKE Q ++I +L + + + L ++ L ++ +
Sbjct: 1273 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1332
Query: 191 LQKQVSVLRQNQVEFEGLKH--------EIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
L Q L + +E + L H ++ L + E L ++ D + + S +
Sbjct: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1392
Query: 243 ALETLKTER--EQKNSLRKE 260
TLK + + K + +E
Sbjct: 1393 NWITLKMRKLIKSKKDINRE 1412
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 83.2 bits (204), Expect = 9e-16
Identities = 196/911 (21%), Positives = 342/911 (37%), Gaps = 138/911 (15%)
Query: 3 APSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREK-------------IQAAEYGLA 49
A +E+E+ A E + + L E+ L +A T+EK +QA E ++
Sbjct: 1011 AKAEKEKQAT---ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVS 1067
Query: 50 VLEE-KHQLKLQFEELEVDYEA---IRSEMEQLKEAF-GQAHTNHKKVA---ADGESREE 101
L + K +L+ Q E+LE E +R + E+ K G + VA D + EE
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127
Query: 102 SLIQESASKEQYYVR-------------KVLELQTELKQLRNVLTNTQSENERL----AS 144
L ++ + Q +R K+ ELQ ++L L ++ R+ A
Sbjct: 1128 KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAE 1187
Query: 145 VAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVE 204
A+EL+E+++ +E G + + REA L + ELEE + + V+ LR+ Q E
Sbjct: 1188 AARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAE 1247
Query: 205 --------FEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS 256
+ L+ ++LE+E L +++D E R A + +T +Q +
Sbjct: 1248 GAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE 1307
Query: 257 LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG------GLAK 310
+ ++ T + + S + + + E L++ G L +
Sbjct: 1308 AKIKVEELQRQLADASTQRGRLQTE----SGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 311 LPLDNKTSTPKKEGLAPPSPSLVSD--------------------LLSELNISEIQKLK- 349
L + + K LA +L D LLS+ N Q
Sbjct: 1364 LRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSK 1423
Query: 350 ------QQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQA 402
Q+ ++E K L LQ+ ++ +E S ++ RL TE+ L+
Sbjct: 1424 YEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELER 1483
Query: 403 SKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHE- 461
+ ALD ++ E E + + A E+ L +L LR HE
Sbjct: 1484 ATSAAAALDKKQRHLERA----LEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 462 ---AREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQG 518
A E E K E E LT++VSL K+ ++ + LE E ++ E +G
Sbjct: 1540 ALEALETLKRENKNLQE-EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG 1598
Query: 519 SLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEAR 578
+L + + + + EL+ + V E + + R Q S E R
Sbjct: 1599 ALELEETKTLRIQLELSQVKAEVDRKLAE-KDEECANLRRNHQRAV--ESLQASLDAETR 1655
Query: 579 GRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI 638
R + L K + +G D L L R+ +++ Q+
Sbjct: 1656 ARNEALRLKK--------KMEGDLND--------LELQLGHATRQATEAQAATRLMQAQL 1699
Query: 639 KHLQAAVDRTTELSRQRIASQ--ELGPAVDKDKEALMEEILKLKSLLST-KREQITTLRT 695
K QA D QR+A++ E A+++ L E+ +L++ L +R + +
Sbjct: 1700 KEEQAGRD-----EEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQE 1754
Query: 696 VLKANKQ-----TAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMF 750
+L+A ++ + L N K K E + A ++ + + E + +E A + AM
Sbjct: 1755 LLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM 1814
Query: 751 ATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQ----------QKLALTQRLELLE 800
A + ++R E + L + L A Q QKL R E
Sbjct: 1815 AEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874
Query: 801 LDHEQTRRGRA 811
LD EQ + A
Sbjct: 1875 LDAEQKKHAEA 1885
Score = 76.3 bits (186), Expect = 1e-13
Identities = 181/815 (22%), Positives = 324/815 (39%), Gaps = 165/815 (20%)
Query: 2 SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
SA +EEE A LRAE++ L LA ++ + E +++ +EK+ L LQ
Sbjct: 891 SAQAEEELAA----------LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQ- 939
Query: 62 EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
+++E + L AD E R LI+ ++L
Sbjct: 940 ---------LQAEQDNL---------------ADAEERCHLLIKSK-----------VQL 964
Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
+ ++K+L +ERL ++ +E+N ++ +R +L D+ E K
Sbjct: 965 EGKVKEL----------SERL----EDEEEVNADLAARRRKLEDECTELK---------- 1000
Query: 182 SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
++++ ++L K + E + ++++K L EE L+ + + K+ + +
Sbjct: 1001 KDIDDLKLTLAKA-------EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Query: 242 EALETLKTEREQKNSLRK-ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
+AL L+ E ++ ++L K +L + D L SL+ K
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVED------LECSLEQEK---------------- 1091
Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKA 360
KL +D + + K EG + V+D + Q+L+++L + + E +
Sbjct: 1092 ---------KLRMDTERAKRKLEGDLKLTQESVADAAQDK-----QQLEEKLKKKDSELS 1137
Query: 361 GLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHE 420
L ++D Q + + E Q + L E L A R +A E+Q A E R+ E
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRA---EAARELEE 1194
Query: 421 DGDYYEV--DINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
+ E + + C+ A E G LR +L+ HEA A R +AEG
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREA--ELGRLRRELEEAALRHEATVAALR----RKQAEG 1248
Query: 479 QA-LTEKVSLLEKASRQDRELLARLEKELK-KVSDVAG--ETQGSLSVAQDELV-TFSEE 533
A L E+V L++ R+ L + + EL+ +V D+A ET + ++L T+ ++
Sbjct: 1249 AAELGEQVDSLQRV----RQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQ 1304
Query: 534 LANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAP 593
L+ V E R + D ++ GR E+ G S +L K L
Sbjct: 1305 LSEAKIKV-----EELQRQLAD----------ASTQRGRLQTES-GELSRLLEEKECLIS 1348
Query: 594 EAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSR 653
+ R S L L + + + + + +R L+ + E
Sbjct: 1349 QLSRGKALAAQSL----EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE--- 1401
Query: 654 QRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAE--VALANL 711
A EL + K + + K ++ + E++ + L Q AE V AN
Sbjct: 1402 ---AQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA 1458
Query: 712 K-SKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
K S E K + + EL+ AA + +E Q +EMQR+L A
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEA 1518
Query: 771 AEDEKKTLNS-LLRMAIQQKLALTQRLELLELDHE 804
A+ E + L + L R+ + AL + LE L+ +++
Sbjct: 1519 AQRESRGLGTELFRLRHGHEEAL-EALETLKRENK 1552
Score = 47.4 bits (111), Expect = 6e-05
Identities = 115/511 (22%), Positives = 199/511 (38%), Gaps = 92/511 (18%)
Query: 349 KQQLMQMEREKAGL---LATLQDTQKQLEHTRGSLSEQQE----KVTRLTENLS-ALRRL 400
+++L + E GL LA + +++LE T S+++++ ++ +NL+ A R
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 401 QASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH 460
+ + L+ + S D EV+ + LA + E EL++ + L+ T
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDEEEVNAD----LAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 461 EAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSL 520
E +EK E + + LTE+++ L+ E +ARL KE K + + + G L
Sbjct: 1011 AKAE----KEKQATENKVKNLTEEMAALD-------ESVARLTKEKKALQEAHQQALGDL 1059
Query: 521 SVAQDELVTFSEELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEAR 578
+D + ++ L V C+ E ++ +D R + G + +A
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA 1119
Query: 579 GRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI 638
K L + + D S S L + D + L A ++ +I
Sbjct: 1120 Q-------DKQQLEEKLKKKD--------SELSQLSLRVEDEQL-------LGAQMQKKI 1157
Query: 639 KHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST------------- 685
K LQA R EL + A + V+K + E+ +L L
Sbjct: 1158 KELQA---RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR 1214
Query: 686 KRE-QITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETM--------------MKLR 730
KRE ++ LR L+ E +A L+ K A + E + +LR
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 731 NELKALKEDAATFSSLRAMFATRCDEYITQL-------DEMQRQLAAAEDEKKTLNSLLR 783
E+ L + T + +A C Y QL +E+QRQLA A ++ L +
Sbjct: 1275 MEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQT--- 1331
Query: 784 MAIQQKLALTQRLELLELDHEQTRRGRAKAA 814
+ L++ LE E Q RG+A AA
Sbjct: 1332 ----ESGELSRLLEEKECLISQLSRGKALAA 1358
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/251 (18%), Positives = 110/251 (43%), Gaps = 15/251 (5%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
++ A+ E LRA +++ +E ++A E + + L Q ++LE D +
Sbjct: 1729 LLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSG 1788
Query: 74 EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK------EQYYVRKVLELQTELKQ 127
E+E+ + +A KK D E L +E + ++ + V ELQ L++
Sbjct: 1789 EVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEE 1848
Query: 128 LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
+ +++ + +++E+ ++ ++ + + +K + E R+ + + EE+
Sbjct: 1849 AEQAA--LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEED 1906
Query: 188 NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
+L + ++ + Q + + K ++ EE + N+ L + ++ +L++A E
Sbjct: 1907 RKNLARMQDLVDKLQSKVKSYK---RQFEEAEQQANTNLAKYRK----AQHELDDAEERA 1959
Query: 248 KTEREQKNSLR 258
Q N LR
Sbjct: 1960 DMAETQANKLR 1970
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 82.8 bits (203), Expect = 1e-15
Identities = 178/880 (20%), Positives = 343/880 (38%), Gaps = 111/880 (12%)
Query: 16 EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
E + ++ + +R ELA + + + E +++L+EK+ L+LQ ++SE
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQ----------VQSET 899
Query: 76 EQLKEAFGQAHTNHK---------KVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
E L +A + K K + EE + E +K++ K L+ ++
Sbjct: 900 ENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID 959
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
L LT + E + + L E +E +L + K + + L D E+
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019
Query: 187 ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQ 239
+ L K + L Q + EG + K+L + E +LE +++ + S ++Q
Sbjct: 1020 KVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
Query: 240 LEEALE---------TLKTEREQKNSLR-----KEL-------------SHYMSINDSFY 272
+EE L+ K + EQ +SL+ KEL H +
Sbjct: 1080 IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ 1139
Query: 273 TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
S L L+ + + A A+ +N K+ D + +T + E A
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 333 VSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
+D ++EL I +Q++KQ+L E+EK+ L + D +E +LS+ + + R
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKL---EKEKSELKMEIDDMASNIE----ALSKSKSNIERT 1252
Query: 391 TENL-SALRRLQASKERQTA----LDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAE 445
+ ++A E+QT L+ +K R ++G+ +++ A
Sbjct: 1253 CRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL 1312
Query: 446 AGELREQLKALRSTHEAREAQ-HAEEKGR---------YEAEGQALTEKVSLLEKASRQD 495
+L E + + +A+ A HA + R YE E +A E L KA+ +
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 496 RELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV--- 552
+ + E + + ++ E + L+ E +EE + C +T R+
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQE----AEENTETANSKCASLEKTKQRLQGE 1428
Query: 553 MLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL------LPKGLLAPEAGRADGGTGDSS 606
+ D R+ + R+ T + + +L L + EA + + + +
Sbjct: 1429 VEDLMRDLE----RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 607 ----PSPGSSLPSPLSDPRREPMNIYNLIAIIRDQI----KHLQAAVDRTTELSRQ---- 654
+ + L RRE N+ I+ + +QI K+LQ A ++T +L Q
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA-EKTKKLVEQEKSD 1543
Query: 655 -RIASQELGPAVDKDKEALME---EILKLKSLLSTKREQITTLRTVLKANKQTAEVALAN 710
++A +E+ +++ ++ ++ E+ ++KS L K + LK N Q A AL +
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 711 LKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
+ + K+ +L ++ + A QL + Q L
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663
Query: 771 AEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
A + L L + ++ L + LE +++ EQT R R
Sbjct: 1664 ALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703
Score = 73.2 bits (178), Expect = 9e-13
Identities = 185/917 (20%), Positives = 363/917 (39%), Gaps = 156/917 (17%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE-- 63
E+E++A E + + L E+ L +++ T+EK E L++ LQ EE
Sbjct: 969 EKEKHAT---ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD-----LQVEEDK 1020
Query: 64 ----------LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL---------I 104
LE + + +EQ K+ +K+ D + +ES+ I
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080
Query: 105 QESASKEQY------------------YVRKVLELQTELKQLRNVLTNTQSENERL---- 142
+E K+++ + +K+ ELQ +++L + + ++
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR 1140
Query: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202
+ +A+EL+EI++ +E G I+ K REA + +LEE + + + LR+ Q
Sbjct: 1141 SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQ 1200
Query: 203 VE--------FEGLKHEIKRLEEETEYLNSQLED-AIRLKEISE---------RQLEEAL 244
+ + L+ ++LE+E L +++D A ++ +S+ R +E+
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 245 ETLKTEREQKNSL--------------RKELSHYMSINDSFYTS------HLHVSLDGLK 284
+K + EQ+ L ELSH + +S + L L+ LK
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 285 --FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK-EGLAPPSPSLVSDLLSELN 341
++ N A AL + L + + + + + + S V+ ++
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 342 ISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR-L 400
IQ+ ++ +E K L LQ+ ++ E + ++ RL + L R L
Sbjct: 1381 TDAIQRTEE----LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 401 QASKERQTALDNEKDRDSHEDGDYYE-VDINGPEILACKYHVAVAEAGELREQLKALRST 459
+ S LD ++ ++ + +D + E+ A A E+ L +L +R+
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA-----AQKESRSLSTELFKMRNA 1491
Query: 460 HEA----REAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGE 515
+E E E K E E LTE+++ K ++ + +E+E + E
Sbjct: 1492 YEEVVDQLETLRRENKNLQE-EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550
Query: 516 TQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSP 575
+GSL + +++ EL+ + + E + R Q A
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIE-QLKRNSQRAAEALQ--SVLDA 1607
Query: 576 EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIR 635
E R R + L K + +G + G S R+ + ++
Sbjct: 1608 EIRSRNDALRLKK--------KMEGDLNEMEIQLGHS--------NRQMAETQKHLRTVQ 1651
Query: 636 DQIKHLQAAVD---RTTELSRQRIASQELGPAVDKDKEALMEEILKLK-SLLSTKREQIT 691
Q+K Q +D R+ E ++++A V++ L+EE+ ++K +L T+R +
Sbjct: 1652 GQLKDSQLHLDDALRSNEDLKEQLA------IVERRNGLLLEELEEMKVALEQTERTRRL 1705
Query: 692 TLRTVLKANKQ-----TAEVALANLKSKYENE----KAMVTETMMKLRN-ELKALKEDAA 741
+ + +L A+ + + +L N K K E + +A V ++ + RN E KA K A
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKK--AI 1763
Query: 742 TFSSLRAMFATRCDEYITQLDEMQRQL-AAAEDEKKTLNSLLRMAIQQKLALTQRLELL- 799
T +++ A + + L+ M++ L +D + L+ ++A++ Q+LE
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRV 1823
Query: 800 -----ELDHEQTRRGRA 811
ELD EQ R A
Sbjct: 1824 RELENELDVEQKRGAEA 1840
Score = 62.4 bits (150), Expect = 2e-09
Identities = 147/749 (19%), Positives = 296/749 (39%), Gaps = 94/749 (12%)
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
+++ +L + ++E E +A++ ++ + + E+ R R KE + + LLQ+ ++L+
Sbjct: 839 KIKPLLKSAEAEKE-MATMKEDFERTKE--ELARSEARR--KELEEKMVSLLQEKNDLQ- 892
Query: 187 ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE---ISERQLEEA 243
+ +Q + L + EGL LE + + L +LE+ + +R LE+
Sbjct: 893 --LQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950
Query: 244 LETLK-------------------TEREQKN------SLRKELSHYMSINDSFYTSHLHV 278
+LK TE + KN +L + +S S +H
Sbjct: 951 CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH-QQ 1009
Query: 279 SLDGLKFSDDAA----EPNNDAEALVNGFEHGGL---AKLPLDNKTSTPKKEGLAPPSPS 331
+LD L+ +D + N E + E G L KL D + + K EG S
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLE-GSLEQEKKLRADLERAKRKLEGDLKMSQE 1068
Query: 332 LVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLT 391
+ DL ++ Q+++++L + E E + L A + D Q + + E Q ++ L
Sbjct: 1069 SIMDLENDK-----QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 392 ENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELRE 451
E + A L+A E+Q ++ R+ E + E AE ++R
Sbjct: 1124 EEIEAEHTLRAKIEKQR---SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR 1180
Query: 452 QLKALRSTHEAREAQHAEEKGRYEAE-GQALTEKVSLLEKASRQDRELLARLE---KELK 507
L+ HEA A +++ AE G+ + + +K ++ EL ++ ++
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240
Query: 508 KVSDVAGETQGSLSVAQD---ELVTFSEELANLYHHVCM--CNNETPNRVMLDYYREGQG 562
+S + + +D E+ E+ L H + M +T N + E +
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300
Query: 563 GAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRR 622
+ + S +A ++ L + +A A SS L + +
Sbjct: 1301 LISQLT----KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 623 EPMNIYNLIAIIRDQI-----KHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEIL 677
+ ++ ++ K+ A+ RT EL A ++L + + +E
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE---AKKKLAQRLQEAEENTETANS 1413
Query: 678 KLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKL---RNELK 734
K SL TK+ + +++ + + + A A L K N ++ E KL + EL+
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMR-DLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELE 1472
Query: 735 ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLL------------ 782
A ++++ + S+ +E + QL+ ++R+ ++E L +
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532
Query: 783 --RMAIQQKLALTQRLELLE--LDHEQTR 807
++ Q+K L LE +E L+HE+++
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Score = 59.3 bits (142), Expect = 1e-08
Identities = 139/701 (19%), Positives = 263/701 (37%), Gaps = 138/701 (19%)
Query: 157 EIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLR-QNQVEFEGLKHEIKRL 215
E + +++D + K AR ELEE+ +SL ++ + L+ Q Q E E L +R
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 216 EEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSH 275
E I+ K + E +++E E L+ E E + L ++ ++ D S
Sbjct: 910 E-----------GLIKSKILLEAKVKELTERLEEEEEMNSEL---VAKKRNLEDK--CSS 953
Query: 276 LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSD 335
L +D L+ + L K+ + + K + L+ +L
Sbjct: 954 LKRDIDDLELT---------------------LTKVEKEKHATENKVKNLSEEMTAL--- 989
Query: 336 LLSELNISEIQKLKQQL----------MQMEREKA-GLLATLQDTQKQLEHTRGSLSEQQ 384
E NIS++ K K+ L +Q+E +K GL+ ++Q + GSL +Q
Sbjct: 990 ---EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL--EQ 1044
Query: 385 EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
EK R + L R + E + E D D E + E + +
Sbjct: 1045 EKKLR-----ADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
+ EQ+ +L+ + +E Q E+ E E + +L K +Q +L LE+
Sbjct: 1100 D-----EQVHSLQFQKKIKELQARIEELEEEIEAEH-----TLRAKIEKQRSDLARELEE 1149
Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSE-----ELANLYHHVCMCNNETPNRVMLDYYRE 559
+++ + +G T + + + F + E A L H R+
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT-----------LRK 1198
Query: 560 GQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSD 619
Q A + G + + + K L E + S +
Sbjct: 1199 KQ--ADSVAELGEQIDNLQRVKQKLEKEKSELKMEI---------------DDMASNIEA 1241
Query: 620 PRREPMNIYNLIAIIRDQIKHLQAAVDRTTEL--------SRQRIASQELGPAVD----- 666
+ NI + DQ ++A ++ T+L +R + + EL V+
Sbjct: 1242 LSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301
Query: 667 -----KDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM 721
K K+AL +++ +LK + + + + L++++ ++ L+ +YE E+
Sbjct: 1302 ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL----LREQYEEEQEA 1357
Query: 722 VTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLA----AAEDEKKT 777
E +AL + + + R + T + +L+E +++LA AE+ +T
Sbjct: 1358 KAELQ-------RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Query: 778 LNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTK 818
NS + K L +E L D E++ A K +
Sbjct: 1411 ANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQR 1451
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/261 (20%), Positives = 111/261 (42%), Gaps = 28/261 (10%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTR-------EKIQAAEYGLAVLEEKHQLKLQFEELEV 66
++E + L E++ + L +T R E + A++ + + L ++LE
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736
Query: 67 DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
D ++E+E + A KK D +++ E KEQ + ++ L+
Sbjct: 1737 DIAQCQAEVENSIQESRNAEEKAKKAITDA-----AMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 127 QLRNVLTNTQSENERLA---------SVAQELKEINQNVEIQRGRLRDDIKEYKFREARL 177
Q L + E E+LA + ++E+ +++++ R + +K E ++
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851
Query: 178 LQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE 237
+ + EE++ ++ + ++ + Q + + K ++ EE E N+QL R+ +
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK---RQAEEAEEQANTQLSRCRRV----Q 1904
Query: 238 RQLEEALETLKTEREQKNSLR 258
+LEEA E Q N LR
Sbjct: 1905 HELEEAAERADIAESQVNKLR 1925
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.8 bits (203), Expect = 1e-15
Identities = 164/814 (20%), Positives = 329/814 (40%), Gaps = 115/814 (14%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETT---REKIQAAEYGLAVL-------EEKHQLKLQFEE 63
+M+ + + + E+ LS +L + + I +E A+ EEK +L Q ++
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQD 1416
Query: 64 LEVDYEAIRSE----MEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
L + + E +EQ+ + + + KK A ++ ++ ++E L
Sbjct: 1417 LSFKVDTLSKEKISALEQVDD-WSNKFSEWKKKAQSRFTQHQNTVKE------------L 1463
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
++Q ELK ++E++ + +EL + N+ + +G + DD + + +E+ L
Sbjct: 1464 QIQLELKS-----KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL-- 1516
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR----LKEI 235
+EL+ + + + + Q +E E L +K ++ + + +L ++ L E
Sbjct: 1517 -ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE 1575
Query: 236 SERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNND 295
+ +++EA E + T Q S++ EL H+++S+ + A E +
Sbjct: 1576 KDNRVKEAEEKILTLENQVYSMKAELE-----TKKKELEHVNLSVKSKEEELKALEDRLE 1630
Query: 296 AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL------VSDLLSELNIS------ 343
+E+ E K + K + KK+ L+ LSELN
Sbjct: 1631 SESAAKLAE----LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 344 EIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQA 402
E+ L+++L +E ++ L + + +T ++ Q V + E +S L+R
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 403 SKER---QTALDNEKDRDSH-EDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRS 458
KE+ + + E+ SH E Y+ + E K H + G L+E+L+
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806
Query: 459 THEAREAQHAE-EKGRYEAEGQALTEKVSLLEKASRQDRELLAR-LEKELKKVSDVAGET 516
+ AQH E E G+ + + E V + + Q++EL + LE+++K++
Sbjct: 1807 KYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 517 QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
+ V +EL + E+L L M P ++ + E
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQ---MDGRNKPTELLEENTEEKS--------------- 1908
Query: 577 ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
+S ++ PK L EA D L L+ RE + I ++
Sbjct: 1909 ----KSHLVQPKLLSNMEAQHND-------------LEFKLAGAEREKQKLGKEIVRLQK 1951
Query: 637 QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTV 696
++ L+ + E+ ++ + ++K +E L+LK ST ++ + T
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQER------EEKIKQEQEDLELKH-NSTLKQLMREFNTQ 2004
Query: 697 LKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDE 756
L +Q E+ + +K + +A + E+ + N+L LK+ A L+ A R +E
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL--LKKIAEKDDDLKRT-AKRYEE 2061
Query: 757 YITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
LD + ++ A + +T L+ QQKL
Sbjct: 2062 I---LDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092
Score = 71.6 bits (174), Expect = 3e-12
Identities = 124/550 (22%), Positives = 241/550 (43%), Gaps = 50/550 (9%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
+ +E E+ L ++++ E L+A RL E A E + AE +A + K QL Q
Sbjct: 1601 LETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAI--KKQLLSQ 1658
Query: 61 FEELEVDY----EAIRSEME-QLKEAFGQAHTNHKKVAADGESREESLIQESASK----- 110
EE E Y E+ SE+ +L+E + H +K+ + S+ E+LI ++K
Sbjct: 1659 MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAY 1718
Query: 111 -EQYYVRKVLELQTELKQLRNVLTNTQSENERLAS-VAQELKEINQNVEIQRGRLRDDIK 168
EQ +Q ++ +VL +E E+L V QE +E + R + ++ +
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI 1778
Query: 169 EYKFREARLLQDYS---ELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQ 225
+ + EA+ +D S L+EE K+ S++ VE EG K+ I+ ++ E +
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA-KQNLENVFDD 1837
Query: 226 LEDAIRLKEISERQLEEALETLKTER-EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLK 284
++ ++ KE++ + LE+ ++ L + QK R E+ S + +DG
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ---QMDGRN 1894
Query: 285 FSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT-------STPKKEGLAPPSPSLVSDL- 336
+ E N + ++ + + L+ + + + +K+ L L DL
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 337 -LSELNISEIQKLKQQLMQ-----MEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
L + + E++ LK++ Q +++E+ L T KQL + Q+E+ +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 391 T--ENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEA 446
T E ++ + ++A + Q + + + +D D EIL + A+
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV 2074
Query: 447 GELREQLKALRSTHEAREAQHAEEKGR-----YEAEGQALTEKVSLLEKASRQD---REL 498
+L+ QL+ L+ ++ ++ + E G E + Q L +K +L+ + ++ RE
Sbjct: 2075 RDLQTQLEELQKKYQ-QKLEQEENPGNDNVTIMELQTQ-LAQKTTLISDSKLKEQEFREQ 2132
Query: 499 LARLEKELKK 508
+ LE LKK
Sbjct: 2133 IHNLEDRLKK 2142
Score = 69.3 bits (168), Expect = 1e-11
Identities = 176/864 (20%), Positives = 353/864 (40%), Gaps = 136/864 (15%)
Query: 11 ARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEA 70
A L+ L A++++L+ E T Q A + L EEK Q + ++ D E+
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEE-QNTLNISFQQATHQL---EEKEN---QIKSMKADIES 1315
Query: 71 IRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESAS--------KEQYYVRKVLELQ 122
+ +E E L++ G N ++ A++ ES L +E + KE+ +KV E+
Sbjct: 1316 LVTEKEALQKEGG----NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV-EIS 1370
Query: 123 TELKQLRNV---LTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
+ KQL ++ L N+ S +E+ A+++ K+ ++ ++ L D +++ F+ L +
Sbjct: 1371 SLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE----EKCELLDQVQDLSFKVDTLSK 1426
Query: 180 D-YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL---EDAIRLKEI 235
+ S LE+ + K ++ Q F ++ +K L+ + E + + ++ I L +
Sbjct: 1427 EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE 1486
Query: 236 SERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNND 295
Q + + LK E E S ++ + T+ + ++ D + +
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARI------MELEDHITQKTIE 1540
Query: 296 AEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
E+L ++ K +++K K + L E + +++ +++++ +
Sbjct: 1541 IESLNEVLKNYNQQK-DIEHKELVQKLQHFQE---------LGEEKDNRVKEAEEKILTL 1590
Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENL-------------SALRRLQA 402
E + + A L+ +K+LEH S+ ++E++ L + L A +++ A
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650
Query: 403 SKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHE- 461
K++ + EK+ + + + ++N K E L E+LK++ S+
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELN------TKLQEREREVHILEEKLKSVESSQSE 1704
Query: 462 ----AREAQH-AEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGET 516
R A++ A + EA+ Q +K + EK S R L EKE K + V E
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQK-TYEEKISVLQRNL---TEKE-KLLQRVGQEK 1759
Query: 517 QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
+ ++S + + E L L H + ++ M+ + +E E
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEA---KQHEDQSMIGHLQE--------------ELE 1802
Query: 577 ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
+ ++ +++ A + G ++ +L + D ++ I+
Sbjct: 1803 EKNKKYSLIV--------AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854
Query: 637 QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEAL--MEEILKLKSLLSTKREQITTLR 694
+IK L + + R E+ R+ +EL +K +AL M+ K LL E+ +
Sbjct: 1855 KIKELDSCLVRQKEV--HRVEMEELTSKYEK-LQALQQMDGRNKPTELLEENTEEKSKSH 1911
Query: 695 TV---LKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMF 750
V L +N + L + E EK + + +++L+ +L+ L KE L+ +
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
Query: 751 ATRCDEYITQ----------------LDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQ 794
+E I Q + E QLA E E L M I++ + Q
Sbjct: 1972 DQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE-------LEMTIKETINKAQ 2024
Query: 795 RL--ELLELDHEQTRRGRAKAAPK 816
+ ELLE E+T + K A K
Sbjct: 2025 EVEAELLESHQEETNQLLKKIAEK 2048
Score = 66.2 bits (160), Expect = 1e-10
Identities = 167/895 (18%), Positives = 342/895 (38%), Gaps = 145/895 (16%)
Query: 32 ELAETTREKIQAAEYGLA--------VLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFG 83
E+ E T EK+ + L VL+ +H+L+ + L+ + ++ E+E +
Sbjct: 670 EMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE-- 727
Query: 84 QAHTNHKKVAADGESREESL-IQ--ESASKEQYYVRKVL--ELQTELKQLRNVLTNTQSE 138
NH + D +E + IQ E A K+Q ++L E LK+ + + N +++
Sbjct: 728 --QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
+R Q+ + + + K Y+ + A+L Q +LE E I L KQV+ +
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 199 RQNQ----VEFEGLKHEIKRLEEETEYLNSQLEDAIR-LKEISERQLE------EALETL 247
+ E + K +++ L ++ E NS++E ++ L ++ E +LE E + +
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905
Query: 248 KTERE------------------QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDA 289
E+E QK S +++ H +N+ + T + K A
Sbjct: 906 LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI--LNEEYETKFKNQEKKMEKVKQKA 963
Query: 290 AEPNN-------DAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNI 342
E D EA + +L K K +A + + +SD +S L
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
Query: 343 SEIQKLKQQLMQMEREKAGLLATL------QDTQKQLEHTRGSLSEQQEKVTRLTENL-- 394
++ +++ + L ++ R + + ++ Q ++ E L E++++V L + +
Sbjct: 1024 NQKEQI-ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082
Query: 395 -----------------------SALRRLQASKERQTALDNEKDRDSHE---DGDYYEVD 428
+ L LQ ++++A N +D + + EVD
Sbjct: 1083 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142
Query: 429 INGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLL 488
+N ++ E L+EQL L+ E + + +E + + + S
Sbjct: 1143 LN----------KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH 1192
Query: 489 EKASR--QDREL-LARLEKELKKVSDV-AGETQGSLSVAQDELVTFSEELAN-LYHHVCM 543
EK+++ +D+ L +L +EL D+ +T+ L +EL+ S N + +
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 544 CNNETPN---------------RVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPIL--- 585
C + T L E Q + E + + +
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312
Query: 586 LPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNL-----------IAII 634
+ + EA + +GG + S S + L E +N L I+ +
Sbjct: 1313 IESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSL 1372
Query: 635 RDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLST-KREQITTL 693
Q+ L + + LS + A L D++K L++++ L + T +E+I+ L
Sbjct: 1373 SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL 1432
Query: 694 RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATR 753
V + + +E +S++ + V E ++L + K E + L+ +
Sbjct: 1433 EQVDDWSNKFSEWK-KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 754 CDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRR 808
+ EM+ + E ++ L + L+ +Q ++EL+ T++
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELK---------SQTARIMELEDHITQK 1537
Score = 65.5 bits (158), Expect = 2e-10
Identities = 135/640 (21%), Positives = 260/640 (40%), Gaps = 95/640 (14%)
Query: 5 SEEEEYARLVMEAQPEWLRAE---VKRLS------HELAETTREKIQAAEYGLAVLEEKH 55
S EE+ A+L + E R E K+L E + EK Q+ EY E++
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS-EYLKISQEKEQ 531
Query: 56 QLKLQFEELEVDYEAIRSEME-QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYY 114
Q L EELE+ +AI +E E +L++ +A T ++ S E+SL + +
Sbjct: 532 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 115 VRKVLELQTELKQLRNVLTNTQSENERL-----ASVAQELKEINQNVEIQRGRLRDDIKE 169
V E K++ ++ ++E E L A ++L+ + Q + + +LR+ ++
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 170 YKFREARLLQD-----YSELEEENISLQKQVSVLRQNQVEFEGLKHEIK-------RLEE 217
K LL+D + +EE N +K + L Q E E L E+ +LEE
Sbjct: 652 EK---ETLLKDKEIIFQAHIEEMN---EKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 218 ETEYL----------------------NSQLEDAIRLKEISERQLEEALETLKTE----- 250
E L Q++ I+ E+S ++ E+AL+ +
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 251 REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
+E+ L++ +H ++ S + K D + A LA+
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRSEGELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQ 823
Query: 311 LP---LDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI------QKLKQQLMQMEREKAG 361
L LD +T + D+ +EL+ +I Q+L++Q +ME++
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 362 LL----ATLQDTQKQLEHTRGSLSEQQEKVTRLTE----NLSALRRLQASKERQTALDNE 413
L + L+D K+ E T+ L E++ + ++ E + L + ++KE + NE
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 414 --KDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQ-HAEE 470
+ + +++ +V E+ + + +L+++L+ +E Q +A+
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 471 KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTF 530
+A +++ VS LE ++ E L + + ++++DV + L+ +EL
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--RELNDVISIWEKKLNQQAEELQEI 1061
Query: 531 SE--------ELANLYHHVCM--CNNETPNRVMLDYYREG 560
E E+A L + + C E N+ + EG
Sbjct: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Score = 56.2 bits (134), Expect = 1e-07
Identities = 137/715 (19%), Positives = 284/715 (39%), Gaps = 115/715 (16%)
Query: 133 TNTQSENERLASVAQELKEINQNVEIQR-GRLRDDIKEYKFREARLLQDYSELEEENISL 191
++ SE E L + L N+ IQR R+ + Y+ + + L+ Y L+ E L
Sbjct: 118 SDMDSEAEDLVGNSDSL---NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKL 174
Query: 192 QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
Q +L Q+Q + ++R+ E E L + L+E + LEE + + +
Sbjct: 175 Q---GILSQSQDK------SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225
Query: 252 EQKNSLRKELSHY-MSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAK 310
Q + L++ L + M+++ L + ++ P +D E +V G +
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEEN---PESDGEPVVED----GTSV 278
Query: 311 LPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQ 370
L+ K++ +LL IQ K+Q + EK L L +
Sbjct: 279 KTLETLQQRVKRQ----------ENLLKRCK-ETIQSHKEQCTLLTSEKEALQEQLDERL 327
Query: 371 KQLEHTRG-SLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI 429
++LE + ++E+ + +T+L + + + +L+ K A E R HE + E +I
Sbjct: 328 QELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA---ETKRQMHETLEMKEEEI 384
Query: 430 NGPEILACKYHVAVAEAGELREQLKALRST-HEAREAQHAEEKGRYEAEGQALTEKVSLL 488
+LR ++K + + E RE + E+ +E +AL S
Sbjct: 385 -----------------AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL----STA 423
Query: 489 EKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNET 548
+K R+L A +++++K + +++E ++ +EL+ + V ++
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIE----------KTSEEERISLQQELSRVKQEVVDVMKKS 473
Query: 549 PNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS 608
+ + + R + R R + L E +++
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVAL---EKSQSEYLKISQEKE 530
Query: 609 PGSSLP---------SPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQ 659
SL + L++ + ++ R +I L+++++++ + ++ + S+
Sbjct: 531 QQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ--SK 588
Query: 660 ELGPAVDKDKEALMEEILKL-----KSLLSTKREQITTLRTVLKANKQTAEVALANLKSK 714
+L ++ +K +EI + L S K +Q L+ KQ + + L+ K
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 715 YENEKA----------------MVTETMMKL---RNELKALKEDAATFSSLRAMFATRCD 755
E EK M +T+ KL + EL++L + + R
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 756 EYITQLDEMQRQLAAAEDEKKT-----LNSLLR---MAIQQ-KLALTQRLELLEL 801
Q D+M+++L A DE+K ++S+++ ++IQ+ + AL ++ LEL
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Score = 55.5 bits (132), Expect = 2e-07
Identities = 150/790 (18%), Positives = 308/790 (38%), Gaps = 89/790 (11%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVL-EEKHQLKLQFEELEVDYEAIRSEMEQL 78
E L+ VKR L + +E IQ+ + +L EK L+ Q +E E+E++
Sbjct: 282 ETLQQRVKR-QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER-------LQELEKI 333
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESA---SKEQYYVRKVLEL-QTELKQLRNVLTN 134
K+ T D ++ E L Q+ ++ + + + LE+ + E+ QLR+ +
Sbjct: 334 KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQ 393
Query: 135 TQSENERLA--------SVAQELKEI---NQNVEIQRGRLRDDIKEYKFREARLLQDYSE 183
++ E L + +EL++ Q E R +L+ ++ E + + ++ SE
Sbjct: 394 MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE----QIKTIEKTSE 449
Query: 184 LEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEA 243
EE ISLQ+++S ++Q V+ K EE+ L E + K E++L +
Sbjct: 450 --EERISLQQELSRVKQEVVDVMK-----KSSEEQIAKLQKLHEKELARK---EQELTKK 499
Query: 244 LETLKTE--REQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDA--AEPNNDAEAL 299
L+T + E + K +L K S Y+ I+ ++L+ L+ A E N L
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQE-KEQQESLALEELELQKKAILTESENKLRDL 558
Query: 300 VNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREK 359
E L L++ +E + + DL L + + K+ + +E+ K
Sbjct: 559 QQEAETYRTRILELESSLEKSLQE-----NKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 360 AGLLATLQDTQKQLEHTRGSL-SEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDS 418
L + L+H + +L +E+ + + + + R + +E++T L KD++
Sbjct: 614 TEL--------ESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL---KDKEI 662
Query: 419 HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREA-QHAEEKGRYEAE 477
E++ E L K + + EL E LKA E + +K + E E
Sbjct: 663 IFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
Query: 478 GQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANL 537
+ +K ++ +E +++ K + D + + L L + NL
Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
Query: 538 YHHVCMCNNETPN-RVMLDYYREGQGGAGRTSPGGRTSPEARGRR------SPILLPKGL 590
+ E LD ++ Q + ++ ILL K +
Sbjct: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
EA + D T + + + +L+ + Q ++ V T+
Sbjct: 843 AEVEAQKKDVCT----------------ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 651 LSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALAN 710
+ ++ ++ ++ K+ L+E+ + + ++++I L L A + + +
Sbjct: 887 VYESKL--EDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 711 LKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAA 770
++K++N++ + + K + + LK+ A + +L + ++Q A
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKK---KLLDQEAKLKKELENTALELSQKEKQFNA 1001
Query: 771 AEDEKKTLNS 780
E NS
Sbjct: 1002 KMLEMAQANS 1011
Score = 53.9 bits (128), Expect = 6e-07
Identities = 123/601 (20%), Positives = 240/601 (39%), Gaps = 76/601 (12%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKR--LSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE 63
+ + Y + + Q + L E +R L+ ++AE +K V E K+Q ++
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD-------VCTELDAHKIQVQD 865
Query: 64 LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
L E SEMEQ ++ Q + + + DG +E Q KE +L+++
Sbjct: 866 LMQQLEKQNSEMEQKVKSLTQVYESKLE---DGNKEQEQTKQILVEKE----NMILQMRE 918
Query: 124 ELKQLRNVLTNTQSENERLASVAQELKEIN-QNVEIQRGRLRDDIKE-YKFREARLLQDY 181
K+ +LT S E + E E +N E + +++ KE + + +LL
Sbjct: 919 GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978
Query: 182 SEL--EEENISL-------QKQVSVLRQNQVEFEGLKHEIKRLEEE--------TEYLNS 224
++L E EN +L Q +L Q G+ + RLE TE
Sbjct: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038
Query: 225 QLEDAIRL--KEISER--QLEEALETLKTEREQK-NSLRKELSHYMSINDSFYTSHLHVS 279
+L D I + K+++++ +L+E E E+EQ+ L++++ + + +
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Query: 280 LDGLKFS---DDAAEPNNDAEALVNGFEH------GGLAKLPLDNKTSTPKKEGLAPPSP 330
+G+K ++ E A VN L KL +D S KE
Sbjct: 1099 EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL--KENTFLQEQ 1156
Query: 331 SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVT-- 388
+ +L+E + ++ +L +L + E L ++ + + K LE + E++
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
Query: 389 -----RLTENLSALRR---LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYH 440
+ TE L + + S + A+ + H E + I C
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL----IKTCTVS 1272
Query: 441 VAVAEAGELREQLKAL-----RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQD 495
A+ +L E+ L ++TH+ E ++ + + + E +TEK +L ++ Q
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE-SLVTEKEALQKEGGNQQ 1331
Query: 496 RELLARLEKE--LKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVM 553
+ A EKE + ++ E ++++ ++EL E+++L + N + N +
Sbjct: 1332 Q---AASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Query: 554 L 554
L
Sbjct: 1389 L 1389
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 80.9 bits (198), Expect = 5e-15
Identities = 173/821 (21%), Positives = 312/821 (38%), Gaps = 117/821 (14%)
Query: 13 LVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR 72
L ME + + L +V+ L +E+ + + +++EK QL+ E L + E
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 73 SEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVL 132
+EQ E Q ++ R+ S I A +V +++ E K L +
Sbjct: 554 KILEQENEHLNQTVSS---------LRQRSQISAEA--------RVKDIEKENKILHESI 596
Query: 133 TNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQ 192
T S +L+ + E ++I + +E KE R L + LE+EN LQ
Sbjct: 597 KETSS---KLSKIEFEKRQIKKELE--------HYKEKGERAEELENELHHLEKENELLQ 645
Query: 193 KQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTERE 252
K+++ L+ + E L+ E LE E L L+ S + L LE+L+ E
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLD--------SFKNLTFQLESLEKENS 697
Query: 253 QKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE-----HGG 307
Q + EL + + L+ + + + E L F+
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 308 LAKLPLDNKTSTPKKEGLAPPSPSLVSDLLS--------ELNISEIQKLKQQLMQMEREK 359
L ++N+ E L S+L + N+ E++ ++L Q+E+E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 360 AGL---LATLQDTQKQLEHTRGSLSEQQE-KVTRLTENLSALRRLQASKERQTALDNEKD 415
L + L+ +KQLE L +Q E K T L EN + L+ KE +T
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE--KENKTL------ 869
Query: 416 RDSHEDGDYYEVDINGPEI------LACKYHVAVAEAGELREQLKALRSTHEAREAQHAE 469
S E G Y E + E+ L + + + LRE L + + ++ +
Sbjct: 870 --SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDL 925
Query: 470 EKGRYEAEGQALTEKVSLLEKASRQD---RELLARLEKELKKVSDVAGETQGSLSVAQDE 526
EK +E E L ++ L ++ S D + L ++LE LKK ++ E +L +E
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 985
Query: 527 LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILL 586
++++L + V +Y Q R E + SP
Sbjct: 986 STNYNQQL-----------RQELKTVKKNYEALKQ----------RQDEERMVQSSP--- 1021
Query: 587 PKGLLAPEAGRADGGTGDSSPSPGSSL--PSPLSDPRREPMNIYNLIAIIRDQIKHLQAA 644
P +G + +S + L L + R + ++ Q+K L+
Sbjct: 1022 ------PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET- 1074
Query: 645 VDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTA 704
+ L Q +A Q ++ + L + KL+ ST Q T+L Q A
Sbjct: 1075 --QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM------NQNA 1126
Query: 705 EVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEM 764
++ + +S ENE V + L++ +L +D L A+ + I++ +
Sbjct: 1127 QLLIQ--QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 765 QRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
+ E E + L ++QK L ++L+++ E+
Sbjct: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1225
Score = 79.0 bits (193), Expect = 2e-14
Identities = 161/847 (19%), Positives = 325/847 (38%), Gaps = 79/847 (9%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-HQLKLQFEEL 64
E E ++E + E L V L + +++ E +L E + + ++
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKI 606
Query: 65 EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKV------ 118
E + I+ E+E KE +A ++ +E L+Q+ + + K+
Sbjct: 607 EFEKRQIKKELEHYKEKGERAEELENEL--HHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 119 -LELQTELKQLRNVLTNTQSENERLASVAQELKEINQ-NVEIQRGRLRDDIKEYKFREAR 176
EL+ E ++L+ L + ++ +L S+ +E ++++ N+E++R + +K + A+
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV--ESLKCASMKMAQ 722
Query: 177 LLQDYSELEEENISLQKQVSVLRQN-------QVEFEGLKHEIKRLEEETEYLNS---QL 226
L + ELE E L+K + +L+ + +V ++GL E +RL++ E N QL
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 227 EDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
E ++ E+ + L++ LE LK ++ L KE N S + D +
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKE-------NKSLEQETSQLEKDKKQLE 835
Query: 287 DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKE-GLAPPSPSLVSDLLSELNISEI 345
+ AE E + L+ + T KE G+ S + + E+
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC---------VRLKEL 886
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K ++L++ L TL++ + ++ EK+T E + + E
Sbjct: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
Query: 406 RQTALDNEKDRDSHEDGDYYE-VDINGPEILACKYHVAVAEA--GELREQLKALRSTHEA 462
+ T K +S + + ++I +I A + + + +LR++LK ++ +EA
Sbjct: 947 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
Query: 463 REAQHAEEK------------GRYEAEGQALTEKV----SLLEKASRQDRELLAR---LE 503
+ + EE+ ++E E Q T ++ L + R + L A L+
Sbjct: 1007 LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066
Query: 504 KELKKVSDVAGETQGSLSVAQDELVTFSEELANL--YHHVCMCNNETPNRVMLDYYREGQ 561
+LK++ Q + Q + V+ E+ L + N T N +
Sbjct: 1067 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126
Query: 562 GGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPR 621
+ S + R + L + + + + S SL S +
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-LLHERQASEYESLISKHGTLK 1185
Query: 622 REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKS 681
N+ + D+ L + +L + QE +K+ E + E K
Sbjct: 1186 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK--- 1242
Query: 682 LLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAA 741
L + +++ + L + + NLKS N K T +L E LKE
Sbjct: 1243 -LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT----RLEAEFSKLKEQYQ 1297
Query: 742 TFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLEL 801
+C+ L +++ L E+ + L+ + + +Q + L Q +E +L
Sbjct: 1298 QLDITSTKLNNQCE----LLSQLKGNL--EEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351
Query: 802 DHEQTRR 808
H + R+
Sbjct: 1352 FHVEQRQ 1358
Score = 78.6 bits (192), Expect = 2e-14
Identities = 163/834 (19%), Positives = 324/834 (38%), Gaps = 178/834 (21%)
Query: 25 EVKRLSHELAETTR---EKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
E K + + E TR +K+ E +E QLK + ++E++ + R ++E+L E
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELE------KENLQLKAKLHDMEMERDMDRKKIEELME- 410
Query: 82 FGQAHTNHKKVAADGESREESL--------------IQESASK------EQYYVRKVLEL 121
N A +S +ESL + E+ K + ++L+L
Sbjct: 411 -----ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
Query: 122 QTE-------LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
+ E +++LR + + + ++ + +E + +++ VEI L ++I + K
Sbjct: 466 EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI----LENEIVQEKQSL 521
Query: 175 ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLN---------SQ 225
+L +E L+K + LR+N + +IK LE+E E+LN SQ
Sbjct: 522 QNCQNLSKDLMKEKAQLEKTIETLRENS------ERQIKILEQENEHLNQTVSSLRQRSQ 575
Query: 226 LEDAIRLKEISE------RQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
+ R+K+I + ++E L +K ++KEL HY
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY--------------- 620
Query: 280 LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
E AE L N H L +N+ K L +
Sbjct: 621 ----------KEKGERAEELENELHH-----LEKENELLQKKITNL-------------K 652
Query: 340 LNISEIQKLKQQLMQMEREKAGLLATLQDTQ------KQLEHTRGSLSEQQEKVTRLTEN 393
+ +I+ L+Q+ ++ERE L TL + + LE L E+ ++ R E+
Sbjct: 653 ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 394 L--SALRRLQASKERQTALDNEKD---------RDSHEDGDYYEVDINGPEILACKYHVA 442
L ++++ Q E + L++EK+ + S + + EV G +I +
Sbjct: 713 LKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 443 VAEAG----ELREQLKALRSTHEAREAQHAEEK------GRYEAEGQALTEKVSLLEKAS 492
+ + +L +L+ L ++ + E K + E E ++L ++ S LEK
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRV 552
+Q + RL ++ + E + + E T S+E+ +Y C+ E
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-GIYKESCVRLKELE--- 887
Query: 553 MLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSS 612
+E + R + +T R L+ + L + G +
Sbjct: 888 -----KENKELVKRATIDIKTLVTLR----EDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
Query: 613 LPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEAL 672
L D + + Y L+ L++ + ++ E+ ++IA+ EA
Sbjct: 939 KERLLHDEQSTDDSRYKLLE------SKLESTLKKSLEIKEEKIAA----------LEAR 982
Query: 673 MEEILKLKSLLSTKREQITTLRTVLKANKQ--------TAEVALANLKSKYENEKAMVTE 724
+EE L R+++ T++ +A KQ + ++ +K+E E T
Sbjct: 983 LEESTNYNQQL---RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1039
Query: 725 TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTL 778
++K+++ L ++ + AT + + T+ + TQ + +Q Q+ A + + +L
Sbjct: 1040 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1093
Score = 73.9 bits (180), Expect = 6e-13
Identities = 162/788 (20%), Positives = 312/788 (39%), Gaps = 119/788 (15%)
Query: 94 ADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEIN 153
AD +++ L QE K + ++L+ + EL+Q+ L Q EN L S A+ +
Sbjct: 254 ADAKAKIRRLRQELEEKTE----QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR 309
Query: 154 QNVEIQR------GRLRDDIKEYK-------FREARLLQDYSELEEENISLQKQVSVLRQ 200
++ R +L ++ YK F +AR+ EL+E+N L + ++L
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARV----EELKEDNQVLLETKTMLED 365
Query: 201 NQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEAL-ETLKTEREQKNSLRK 259
++ LE+E L ++L D +++ +++EE + E + E QK S+ +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 260 ELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE-PNNDAEALVNGFEHGGLAKLPLDNKTS 318
L HL L+ + + + +E P VN L KL ++N++
Sbjct: 426 SL-------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 319 TPKKEGLAPPSPSLVSDLLSELNI-SEIQKLKQQLMQMEREKAGLLATLQDTQK------ 371
T E L S+ + L + E Q+L +++ +E E +LQ+ Q
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 372 ----QLEHTRGSLSEQQEKVTR--------LTENLSALR-RLQASKERQTALDNEKDRDS 418
QLE T +L E E+ + L + +S+LR R Q S E + ++++
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKIL 592
Query: 419 HEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG 478
HE ++ E E +++++L+ + E R + E E E
Sbjct: 593 HESIKETSSKLSKIEF----------EKRQIKKELEHYKEKGE-RAEELENELHHLEKEN 641
Query: 479 QALTEKVSLLE------KASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE 532
+ L +K++ L+ +A Q+ L R ++LKK D L + E E
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 533 ELANLYHHV--CMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
E L +V C + ++ L+ +E + + G + + + +
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLE-NKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTE 650
L E R T ++S L S L D E ++ ++ L+ + R +
Sbjct: 761 LDIENQRLQ-KTLENSNKKIQQLESELQDLEMENQT-------LQKNLEELKISSKRLEQ 812
Query: 651 LSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTK------------------------ 686
L ++ + ++ ++KDK+ L +E +L+ K
Sbjct: 813 LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 687 ----REQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETM--MKLRNELKALKEDA 740
+E L+ + K NK+ + A ++K+ + +V+E + ++ N+L+ L +
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL 932
Query: 741 ATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
+ DE T D+ + +L ++ E TL L + ++ AL RLE
Sbjct: 933 EKIGLNKERLLH--DEQST--DDSRYKLLESKLE-STLKKSLEIKEEKIAALEARLEEST 987
Query: 801 LDHEQTRR 808
++Q R+
Sbjct: 988 NYNQQLRQ 995
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/260 (23%), Positives = 112/260 (43%), Gaps = 36/260 (13%)
Query: 31 HELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQA----- 85
HE E E+ QA+EY +++ + LK + LEV++ + QL + GQ
Sbjct: 1160 HEKLELLHER-QASEYE-SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
Query: 86 ------------HTNHKKVAADGESREESLIQESASKEQYYVRKVLE---LQTELKQLRN 130
+ NH+ VAA+ + L E+ Y + + E LQT+ K L++
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 131 VLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
+L N++ E RL + +LKE Q ++I +L + + + L ++ L ++ +
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333
Query: 191 LQKQVSVLRQNQVEFEGLKH--------EIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
L Q L + +E + L H ++ L + E L ++ D + + S +
Sbjct: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1393
Query: 243 ALETLKTER--EQKNSLRKE 260
TLK + + K + +E
Sbjct: 1394 NWITLKMRKLIKSKKDINRE 1413
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 80.5 bits (197), Expect = 6e-15
Identities = 186/910 (20%), Positives = 336/910 (36%), Gaps = 145/910 (15%)
Query: 16 EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
E + ++ E ++ ELA++ ++ + E + +++EK+ L+LQ + +
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906
Query: 76 EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
+QL +A Q K+V E EE + E +K++ + EL+ ++ L L
Sbjct: 907 DQLIKAKFQLEAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 965
Query: 136 QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
+ E + + L E ++ +L + K + + L D E++ SL K
Sbjct: 966 EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025
Query: 196 SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQLEEALE--- 245
S L Q + E + K+L + E +LE ++L + S ++QL+E L+
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085
Query: 246 ------TLKTEREQKNSLR-----KEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN 293
K E EQ L+ KEL + + + + + SD A E
Sbjct: 1086 FEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145
Query: 294 NDAEAL------------VNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL- 340
+E L +N KL D + +T + E + +D ++EL
Sbjct: 1146 ELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELG 1205
Query: 341 -NISEIQKLKQQLMQ------------------MEREKAGLLATLQDTQKQLEHTRGSLS 381
I +Q++KQ+L + + + KA L + + QL RG
Sbjct: 1206 EQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 1265
Query: 382 EQQEKVTRLT------------------ENLSALRRLQASKERQTALDNEKDRDSHEDG- 422
E Q ++ LT E S + +L SK+ T E R E+
Sbjct: 1266 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325
Query: 423 --------------------DYYEVDINGPEILACKYHVAVAEAGELREQLK--ALRSTH 460
+ YE + G L A +E + R + + A++ T
Sbjct: 1326 AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE 1385
Query: 461 EAREAQH--AEEKGRYEAEGQALTEKVSLLEKASR--------------QDRELLARLEK 504
E EA+ A+ E + +A+ K + LEK + + L A L+K
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNN---------ETPNRVMLD 555
+ + V E + +Q EL +E +L + N ET R +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Query: 556 YYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
+E + + G+T E R I L K + A+ + + +
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAAL-EHEEAKILRIQL 1564
Query: 616 PLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEE 675
L+ + E I IA ++I+ L+ RT E + A+D + + E
Sbjct: 1565 ELTQVKSE---IDRKIAEKDEEIEQLKRNYQRTVETMQS---------ALDAEVRS-RNE 1611
Query: 676 ILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA 735
++LK + +I + AN+Q AE L +L+S + + +T + L + L+
Sbjct: 1612 AIRLKKKMEGDLNEIEI--QLSHANRQAAE-TLKHLRS----VQGQLKDTQLHLDDALRG 1664
Query: 736 ---LKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL 792
LKE A + +E L++ +R AE E N +++ Q +L
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 793 TQRLELLELD 802
+ LE D
Sbjct: 1725 IHTKKKLETD 1734
Score = 61.2 bits (147), Expect = 4e-09
Identities = 120/576 (20%), Positives = 237/576 (41%), Gaps = 83/576 (14%)
Query: 9 EYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDY 68
E A L EA LR + EL E + +Q + L +EK + KL+ ++L
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQI-DNLQRVKQKLE--KEKSEFKLEIDDLSSSM 1236
Query: 69 EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
E++ L++ + E + SL + + K + + EL +L++
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT-EAGELSRQLEEK 1295
Query: 129 RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
++++ + +ELK + + L ++ + L + Y E +E
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 189 ISLQKQVSVLRQNQVEFEGLKHEI------KRLEEETEYLNSQLED------AIRLK--- 233
LQ+ +S ++ K+E + LEE + L +L+D A+ K
Sbjct: 1356 AELQRALSKANSEVAQWR-TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414
Query: 234 -EISERQLEEALETLKTEREQKNSLRKELSHYMSINDSF---YTSHLHVSLDGLKFS-DD 288
E ++++L+ +E L + E+ NSL L D + + S L+ S +
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 289 AAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL--NISEIQ 346
+ + + L N +E LD + T K+E ++DL ++ N I
Sbjct: 1475 SRSLSTELFKLKNAYEEA------LD-QLETVKRENKNLEQE--IADLTEQIAENGKTIH 1525
Query: 347 KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSL-----------SEQQEKVTRLTENLS 395
+L++ Q+E EKA + L++ + LEH + SE K+ E +
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585
Query: 396 ALRR--LQASKERQTALDNEKDRDSHE--------DGDYYEVDINGPEILACKYHVAVAE 445
L+R + + Q+ALD E R +E +GD E++I ++
Sbjct: 1586 QLKRNYQRTVETMQSALDAEV-RSRNEAIRLKKKMEGDLNEIEIQ------------LSH 1632
Query: 446 AG-ELREQLKALRSTH-EAREAQ-HAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARL 502
A + E LK LRS + ++ Q H ++ R + + L E+++++E+ + L
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED---LKEQLAIVERRAN-------LL 1682
Query: 503 EKELKKVSDVAGETQGSLSVAQDELVTFSEELANLY 538
+ E++++ +T+ + +A+ EL+ +E + L+
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Score = 58.5 bits (140), Expect = 2e-08
Identities = 115/511 (22%), Positives = 212/511 (41%), Gaps = 84/511 (16%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
E L K+L+ L ++ E+++A A LE+ K +L+ + E+L VD E S L
Sbjct: 1385 EELEEAKKKLAQRLQDS-EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS----L 1439
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
A + N KV A+ +++ E ES ++ + +++ L TEL +L+N
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCE----ESQAELEASLKESRSLSTELFKLKNAY------ 1489
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
E + +K N+N+E Q+ ++L E+ K + L
Sbjct: 1490 -EEALDQLETVKRENKNLE---------------------QEIADLTEQIAENGKTIHEL 1527
Query: 199 RQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLR 258
+++ + E K +I+ EE E A+ +E +++ L +K+E ++K + +
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEA-------ALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 259 KELSHYMSINDSFYTSHLHVSLDG-LKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT 317
E + N + +LD ++ ++A E +N E +L N+
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE----IQLSHANRQ 1636
Query: 318 STPKKEGLAPPSPSLVSDLLSELNISEI----QKLKQQLMQMER-------EKAGLLATL 366
+ + L L ++L++ + + LK+QL +ER E L ATL
Sbjct: 1637 AAETLKHLRSVQGQLKD---TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL 1693
Query: 367 QDTQKQLEHTRGSLSEQQEKVTRL-TENLSALRRLQASKERQTALDNEKDRDSHEDGDYY 425
+ T++ + L + E+V L T+N S + + + L +E + S + +
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAE 1753
Query: 426 EVDINGPEILACKYHVAVAEAGELREQLKALRST--HEAREAQHAEEKGR------YEAE 477
E K A+ +A + E+LK + T H R ++ E+ + EAE
Sbjct: 1754 E-----------KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 478 GQALTEKVSLLEKASRQDRELLARLEKELKK 508
AL ++K + REL LE E KK
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKK 1833
Score = 52.4 bits (124), Expect = 2e-06
Identities = 114/640 (17%), Positives = 234/640 (36%), Gaps = 77/640 (12%)
Query: 192 QKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
+K+++ +++ EF+ K E+ + E + + L +L ++ K + Q++ E L
Sbjct: 847 EKEMATMKE---EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 252 EQ-------KNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE 304
E+ K L ++ + + ++ K D+ +E D + L
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL----- 958
Query: 305 HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLA 364
LAK+ + + K + L L + I+++ + K+ L + ++ L
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGL------DETIAKLTREKKALQEAHQQALDDLQ 1012
Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR----RLQASKERQTALDNEKDRDSHE 420
+D L T+ L +Q E + E LR R + E L E D
Sbjct: 1013 AEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN 1072
Query: 421 DGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA 480
D + + + C+ V + EQ L+ + +E Q E+ E E +
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVED-----EQTLGLQFQKKIKELQARIEELEEEIEAER 1127
Query: 481 LTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSE-----ELA 535
T K +Q + LE+ +++ + G T + + + F + E A
Sbjct: 1128 ATRA-----KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182
Query: 536 NLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEA 595
L H + + A + G + + + K E
Sbjct: 1183 TLQHEAMVAALRKKH-------------ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 596 GRADGGTGDSSPSPGS------SLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
S S + +L LS+ R + I ++ + Q LQ
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG--- 1286
Query: 650 ELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALA 709
ELSRQ + + + + K+A ++ +LK L + + L L++++ ++
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL--- 1343
Query: 710 NLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLA 769
L+ +YE E+ E +AL + + + R + T + +L+E +++LA
Sbjct: 1344 -LREQYEEEQEGKAELQ-------RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395
Query: 770 A----AEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
+E++ + +N+ + K L +E L +D E+
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/215 (21%), Positives = 95/215 (44%), Gaps = 19/215 (8%)
Query: 51 LEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK 110
L + LK Q +E +++E+E+L+ Q K E+ L+ +
Sbjct: 1662 LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA-------EQELLDSNERV 1714
Query: 111 EQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEY 170
+ + + + T+ K+L L QSE E + A+ +E + + +++K+
Sbjct: 1715 QLLHTQNTSLIHTK-KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773
Query: 171 KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE--- 227
+ A L + LE+ LQ ++ Q+ +G K +I++LE L +LE
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQHRLD--EAEQLALKGGKKQIQKLETRIRELEFELEGEQ 1831
Query: 228 ----DAIRLKEISERQLEEALETLKTEREQKNSLR 258
++++ ER+++E T ++E ++KN LR
Sbjct: 1832 KKNTESVKGLRKYERRVKEL--TYQSEEDRKNVLR 1864
Score = 41.2 bits (95), Expect = 0.004
Identities = 85/422 (20%), Positives = 175/422 (41%), Gaps = 51/422 (12%)
Query: 3 APSEEEEYARLVMEAQPEWLRAEVKRL----SHELAETTREKIQAAEYGLAVLEEKHQLK 58
A E EE L ++ + +++E+ R E+ + R + E + L+ + + +
Sbjct: 1550 AALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR 1609
Query: 59 LQFEELEVDYEAIRSEME-QLKEAFGQAHTNHKKV-AADGESREESLIQESASKEQYYVR 116
+ L+ E +E+E QL A QA K + + G+ ++ L + A + Q ++
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 117 KVLE--------LQTELKQLRNVLTNTQSENERLASVA-QELKEINQNVEIQRGRLRDDI 167
+ L LQ E+++LR L T ER +A QEL + N+ V++ + I
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQT----ERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Query: 168 KEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE 227
K E L+Q SE+E+ + + ++ + + E+K+ ++ + +L +
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 228 DAIRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFS 286
+ + + + +L+EA + LK ++Q L + L L+G
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI------------RELEFELEG---- 1829
Query: 287 DDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ 346
E + E+ V G L ++ +K L + DL+ +L + +++
Sbjct: 1830 ----EQKKNTES-VKGLRKYERRVKELTYQSEEDRKNVLR------LQDLVDKLQV-KVK 1877
Query: 347 KLKQQLMQMEREKAGLLATLQDTQKQLEHT--RGSLSEQQ-EKVTRLTENLSALRRLQAS 403
K+Q + + + L + Q +LE R ++E Q K+ T + ++ R +
Sbjct: 1878 SYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
Query: 404 KE 405
E
Sbjct: 1938 SE 1939
Score = 33.5 bits (75), Expect = 0.83
Identities = 41/184 (22%), Positives = 71/184 (38%), Gaps = 35/184 (19%)
Query: 354 QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE 413
+ E+E A + Q T+ +L + E +EK+ L + + L+ LQ E + LD E
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ-LQVQAESENLLDAE 903
Query: 414 KDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGR 473
+ D +++ K+ +L ++K + E E +AE
Sbjct: 904 ERCD---------------QLIKAKF--------QLEAKIKEVTERAEDEEEINAE---- 936
Query: 474 YEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
LT K LE + ++ + LE L KV T+ + +EL E
Sbjct: 937 -------LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
Query: 534 LANL 537
+A L
Sbjct: 990 IAKL 993
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 80.1 bits (196), Expect = 8e-15
Identities = 176/863 (20%), Positives = 348/863 (40%), Gaps = 97/863 (11%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQA------------AEYGLAVLEE 53
EEE + +E ++ + L +LA +E + + L++L+E
Sbjct: 446 EEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505
Query: 54 KHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQY 113
L+ E+LEV + E+ LKE FG H+K E + E SKE
Sbjct: 506 ISSLQ---EKLEVTRTDHQREITSLKEHFGAREETHQK-----EIKALYTATEKLSKENE 557
Query: 114 YVRKVLELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNVEIQRGRLRDDIKEYKF 172
++ LE K+ +V+ +S+ E +AS Q ++E+ + G + E K
Sbjct: 558 SLKSKLEHAN--KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 615
Query: 173 REARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE----IKRLEEETEYLNSQLED 228
+ ++ DY E EN+ Q Q S + E E L+ + IK E E + S+L+
Sbjct: 616 QIEKMRLDYQH-EIENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673
Query: 229 AIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLH------VSLDG 282
A + L+ + + ++ L+ + + + D+F TS L + LD
Sbjct: 674 AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF-TSQLKATEEKLLDLDA 732
Query: 283 LKFSDDAAEP-----NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
L+ + + EA +H + K +K S+ +E L L
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE---LQGRELKLTNL 789
Query: 338 SELNISEIQKLKQQL---MQMEREK-AGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTEN 393
E N+SE+ ++K+ L +Q+ +EK A Q+ ++ T L +++E+ L+ +
Sbjct: 790 QE-NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Query: 394 LSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI---------NGPEILACKYHVAVA 444
L LR A E + +E++ + + E DI N ++ + +
Sbjct: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
E QLK ++ A Q + E +AE Q+ E E+ ++ L+ LEK
Sbjct: 909 ERDVEELQLKLTKANENASFLQKSIEDMTVKAE-QSQQEAAKKHEEEKKELERKLSDLEK 967
Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
+++ + E + A E T EE+ + + +LD + +G
Sbjct: 968 KMETSHNQCQELKARYERATSETKTKHEEIL-----------QNLQKTLLDTEDKLKGAR 1016
Query: 565 GRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREP 624
S + E R + K A A A + +L S L D ++
Sbjct: 1017 EENSGLLQELEELRKQAD-----KAKAAQTAEDAMQIMEQMTKEKTETLAS-LEDTKQTN 1070
Query: 625 MNIYNLIAIIRD-QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLL 683
+ N + +++ +K+++ EL++ S+EL ++ E +EI LK
Sbjct: 1071 AKLQNELDTLKENNLKNVE-------ELNK----SKELLTVENQKMEEFRKEIETLKQAA 1119
Query: 684 STKREQITTLR--TVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNE----LKALK 737
+ K +Q++ L+ V A + K E E++++ +++++ +K
Sbjct: 1120 AQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 738 EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK---KTLNSLLRMAIQQKLALTQ 794
E+ A+ ++ + E +L++++ ++ E K+L+S+++ K+ L
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1239
Query: 795 RLELLELDHEQTRRGRAKAAPKT 817
+++ LEL ++ +R + ++ T
Sbjct: 1240 KVKNLELQLKENKRQLSSSSGNT 1262
Score = 75.5 bits (184), Expect = 2e-13
Identities = 160/797 (20%), Positives = 328/797 (41%), Gaps = 97/797 (12%)
Query: 69 EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
EA++ + + +++ + +VA S + QE A + + VLEL+ ++ QL
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAK-ATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 129 RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
R ++ E L + +L+E + VE + R+ ++ E + + S + E
Sbjct: 414 RTMVEAADREKVELLN---QLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIME-- 468
Query: 189 ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
L+K +++ Q E +RLE + + ++ L+EIS L+E LE +
Sbjct: 469 --LEKDLALRVQEVAELR------RRLESNKPAGDVDMSLSL-LQEIS--SLQEKLEVTR 517
Query: 249 TEREQK-NSLR-----KELSHYMSINDSFYTSHLHVSLDGLKFS---DDAAEPNNDAEAL 299
T+ +++ SL+ +E +H I + YT+ +S + + A + N+D AL
Sbjct: 518 TDHQREITSLKEHFGAREETHQKEIK-ALYTATEKLSKENESLKSKLEHANKENSDVIAL 576
Query: 300 VNGFEHGGLA---KLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNIS---EIQKLKQQ-- 351
+A + + K S K G + + + ++ + EI+ L+ Q
Sbjct: 577 WKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD 636
Query: 352 ------LMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-- 403
+ME +A L+ +++ + LE R L + +++ L E L +LQ +
Sbjct: 637 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ--HLVEMEDTLNKLQEAEI 694
Query: 404 KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAR 463
K ++ + K + + D + + E + E + ++K LR EA
Sbjct: 695 KVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA 754
Query: 464 EAQ--HAE-EKGRYEAEGQALTEKVSLLEKASRQDREL-LARLEKELKKVSDVAGETQGS 519
E Q H E EK ++ ++T ++ Q REL L L++ L +VS V +
Sbjct: 755 EKQIKHLEIEKNAESSKASSITREL--------QGRELKLTNLQENLSEVSQVKETLEKE 806
Query: 520 LSVAQDELVTFSEELANLYHHVCMCNN------ETPNRVMLDYYREGQGGAGRTSPGGRT 573
L + +++ SEE ++ + N E N + D + + A +
Sbjct: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA----K 862
Query: 574 SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAI 633
E R ++ K L + +GD+S S + + L R+ + +
Sbjct: 863 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNS-SQLTKMNDELRLKERDVEELQLKLTK 921
Query: 634 IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
+ LQ +++ T + Q + QE +++K+ L ++ L+ + T Q L
Sbjct: 922 ANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
Query: 694 RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATF---------S 744
K E A + K+K+E + +T++ ++LK +E+ +
Sbjct: 980 -------KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ 1032
Query: 745 SLRAMFATRCDEYITQLDEMQRQ----LAAAEDEKKT-------LNSLLRMAIQQKLALT 793
+ +A A ++ + +++M ++ LA+ ED K+T L++L ++ L
Sbjct: 1033 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1092
Query: 794 QRLELLELDHEQTRRGR 810
+ ELL +++++ R
Sbjct: 1093 KSKELLTVENQKMEEFR 1109
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/450 (20%), Positives = 187/450 (41%), Gaps = 39/450 (8%)
Query: 379 SLSEQQEKVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILAC 437
S+S + + LTE S R++ + Q AL K++ H + E D+ E+
Sbjct: 325 SVSSRPSRTGLLTETSSRYARKISGTTALQEAL---KEKQQHIEQLLAERDLERAEVAKA 381
Query: 438 KYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRE 497
HV GE+ ++L R H+ QH E EA+ L +++E A R+ E
Sbjct: 382 TSHV-----GEIEQELALARDGHD----QHVLE---LEAKMDQLR---TMVEAADREKVE 426
Query: 498 LLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYY 557
LL +LE+E +KV D+ V ++ + E+A + + E + +
Sbjct: 427 LLNQLEEEKRKVEDL------QFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV 480
Query: 558 REGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPL 617
E + P G + L + L E R D +S +
Sbjct: 481 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKL---EVTRTDHQREITSLK--EHFGARE 535
Query: 618 SDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPAVDKDKEALMEE 675
++E +Y + + + L++ ++ + + IA +L A+ ++A+ E
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595
Query: 676 ILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL-K 734
+ L T+ + L+T ++ + + + NL+++ ++E+A + M LR +L K
Sbjct: 596 KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMK 655
Query: 735 ALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL-- 792
+KE + ++R+ D+++ ++++ +L AE + K L L +Q +
Sbjct: 656 VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDN 715
Query: 793 -TQRLELLE---LDHEQTRRGRAKAAPKTK 818
T +L+ E LD + R+ ++ + K
Sbjct: 716 FTSQLKATEEKLLDLDALRKASSEGKSEMK 745
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 80.1 bits (196), Expect = 8e-15
Identities = 109/546 (19%), Positives = 223/546 (40%), Gaps = 68/546 (12%)
Query: 2 SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
S E +E ++ E + + E K L + TT +K+ E ++++ ++K
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL-LGELQEQIVQKNQEIKNMK 377
Query: 62 EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
EL + R E++K+ G K+ D + E ++Q + Q RK+ +L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF-ETDIVQRMEQETQ---RKLEQL 433
Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
+ EL ++ Q + + Q + ++ + +G + + ++ Y + + +
Sbjct: 434 RAELDEMYG----QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY----SNITVNE 485
Query: 182 SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
+++ N+++ + L+ + E LK E+ + EE L QLED + S Q++
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545
Query: 242 EALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVN 301
A +T+ + + N K LS + ++ S+ E EA V
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA-----------SESRKELELKHEAEVT 594
Query: 302 GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
++ KL + K + +A + + L ++L S ++L + +E E
Sbjct: 595 NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI 650
Query: 362 LLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDR 416
+ L+D ++Q++ + +S++ E + +NL +K+ Q L+ K +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-------ITKQNQLILEISKLK 703
Query: 417 DSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
D + ++ K + EL+++++ LR Q +EKG E
Sbjct: 704 DLQQS------------LVNSKSEEMTLQINELQKEIEILR--------QEEKEKGTLEQ 743
Query: 477 EGQALTEKVSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSLS----VAQDELV 528
E Q L K LLEK ++ +E A+LE E + D + L V+Q+E +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 529 TFSEEL 534
F + +
Sbjct: 804 IFLDSI 809
Score = 69.7 bits (169), Expect = 1e-11
Identities = 148/766 (19%), Positives = 320/766 (41%), Gaps = 82/766 (10%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
V E Q + + + L+ +L +T +K + E +LEEK L+ Q E+L + R
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 74 EMEQLKEAFGQAHTN----HK----------KVAADGESREESLIQESASKEQYYVRKVL 119
++++ ++ + + HK ++ + ESR+E ++ A Y ++ +
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602
Query: 120 ELQTELKQLRNVLTNTQSENERLA-----SVAQELKEINQNVEIQR----GRLRDDIKEY 170
+ + L + + ++E ERL S +EL ++ +++EI+ +L+D++ +
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 171 KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE-ETEYLNSQLEDA 229
++ LQ+ + E + +K + +QNQ L EI +L++ + +NS+ E+
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ-----LILEISKLKDLQQSLVNSKSEE- 716
Query: 230 IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSD 287
+ +L++ +E L+ E ++K +L +E+ + + + + L KF+
Sbjct: 717 ---MTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 288 DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK 347
AE N+ + E P+ + + + S V + E+ I E +
Sbjct: 773 LEAE-NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 348 LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQ 407
LKQQ +Q+ E T +K E L E+ + ++ ++ L+ SK +Q
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD------LEDSKNKQ 885
Query: 408 TALDNEKDRDSHEDGDYYEVDINGPEILACKY---HVAVAEAGELREQLKALRSTHEARE 464
K + +E+ ++ ++ + + VAE E+ E ++ + T E E
Sbjct: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--KDTTELME 943
Query: 465 AQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
++ + E L++++S L + +Q ++ L +E+K + + Q SL +
Sbjct: 944 KLEVTKREKLE-----LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ--EKEQVSLRCRE 996
Query: 525 DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
E++ N V C+ + + + +G G S ++ G S I
Sbjct: 997 LEIIINHNRAEN----VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEESKI 1048
Query: 585 LLP-----KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK 639
++ + + E + + D PS + P E + + +++ +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP-SENDKLQKELNVLKSEQN 1107
Query: 640 HLQAAVDRTTELSRQRIA-SQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLK 698
L+ ++ QRI S VD+ +E + E K K+L S K E I +K
Sbjct: 1108 DLR------LQMEAQRICLSLVYSTHVDQVREYMENE--KDKALCSLKEELIFAQEEKIK 1159
Query: 699 ANKQTAEVALANLKSKYENEKAMVTETMM-KLRNELKALKEDAATF 743
++ ++ L +K++ ++ ++ KL+ KA+ E+ + F
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ---KAVSEECSYF 1202
Score = 68.9 bits (167), Expect = 2e-11
Identities = 151/811 (18%), Positives = 341/811 (42%), Gaps = 98/811 (12%)
Query: 26 VKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR-----SEMEQLKE 80
+ +L+ L + REK + L + E+ +L++QF++L+ E +R S L +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQ 265
Query: 81 AFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT-----ELKQLRNVLTNT 135
A Q T+ +++ ++ L+++ K++ + ++ LQ E++Q + V +
Sbjct: 266 AKQQILTHQQQL-----EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320
Query: 136 QSENERLASVAQEL-----KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
+ E + ++ +EL +E + +E+ + +L K + +++Q E++ +
Sbjct: 321 KEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLE 379
Query: 191 LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAI--RLKEISERQLEEALETL- 247
L RQ+ E + L ++ L++ + +SQ E I R+++ ++R+LE+ L
Sbjct: 380 LTNSKQKERQSSEEIKQLMGTVEELQKR-NHKDSQFETDIVQRMEQETQRKLEQLRAELD 438
Query: 248 KTEREQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
+ +Q +++EL +M+ + T H + L+ S N D L+N
Sbjct: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-SYSNITVNEDQIKLMN----V 493
Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
+ +L + + + +KE L E+ + ++ ++R+ L+ L
Sbjct: 494 AINELNIKLQDTNSQKEKLK----------------EELGLILEEKCALQRQLEDLVEEL 537
Query: 367 QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY-- 424
+++Q++ R +++EQ+ K+ ++LS + L+A E +A ++ K+ + + +
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTN 595
Query: 425 --YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
++++ E A +A ++ EL L +HE ++ E+ E E +
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED---LEIEHRINI 652
Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
EK L + ++ + L+ E+ + + + +L Q++L+ +L +L +
Sbjct: 653 EK--LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
+E + + +E + G E + + L LL + +
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----ELQLKTELLEKQMKEKE--- 763
Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQR------- 655
+D + + + +I++D+ K L+ + T +S++
Sbjct: 764 ---------------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
Query: 656 IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKY 715
I S+ +K+ E L+EE LK E+I R ++ EV L+ +Y
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 716 -------ENEKAMVTETMMKLRNELKALKED---AATFSSLRAMFATRCDEYITQLDEMQ 765
++ + + ++ +++LKAL E+ + M ++ DE T + E
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928
Query: 766 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRL 796
E + L L + ++KL L+QRL
Sbjct: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRL 959
Score = 61.2 bits (147), Expect = 4e-09
Identities = 118/551 (21%), Positives = 233/551 (42%), Gaps = 79/551 (14%)
Query: 9 EYARLVMEAQPE--WLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
++A+++ E + E L +V +L +L TT K V+EEK++L +LE
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK---------VIEEKNEL---IRDLET 2329
Query: 67 DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
E + S+ E +K N ++ E L QE A+ Q L E
Sbjct: 2330 QIECLMSDQECVKR-------NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2382
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
L++ L +E ++ Q+++ N+ + +++ +KE F+ +L Q+ L+
Sbjct: 2383 SLKHQLDVVIAEK---LALEQQVETANEEMTF----MKNVLKETNFKMNQLTQELFSLKR 2435
Query: 187 ENISLQKQVSV-----------LRQNQVEFEGLKHE--IKRLEEETEYLNSQLEDAIRLK 233
E S++K S+ L +++ E E + E +K LE +T + + + +
Sbjct: 2436 ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII 2495
Query: 234 EISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
+ R QLE + E Q K++ F T L + L+
Sbjct: 2496 NLETRLLQLESTVSAKDLELTQCYKQIKDMQE----QGQFETEMLQKKIVNLQ----KIV 2547
Query: 292 PNNDAEALVNGFEHGGL---AKLPLDNKT--STPKKEGLAPPSPSLVSDLLSELNISEIQ 346
A ALV+ + + AK DN+T S P++ + ++ L + S+I
Sbjct: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-----LNQLREDELGSDIS 2602
Query: 347 KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER 406
L ++ ++E + + +L ++Q+E ++ E+++K+ L + L + Q KE+
Sbjct: 2603 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2662
Query: 407 QTA--------LDNEKDRDSHEDGDYYEVDINGPEILACKYHVA--VAEAGELREQLKAL 456
+ + E + E G + E++ E +A K +A +A +L+E+L +
Sbjct: 2663 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL-LV 2721
Query: 457 RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASR---QDRELLARLEK-ELKKVSDV 512
+ T+ + + + AE + EK+S+LEK Q+ + E +K +
Sbjct: 2722 KETNMTSLQKDLSQVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2778
Query: 513 AGETQGSLSVA 523
A +T G+L ++
Sbjct: 2779 ASQTDGTLKIS 2789
Score = 60.5 bits (145), Expect = 6e-09
Identities = 158/761 (20%), Positives = 308/761 (40%), Gaps = 128/761 (16%)
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
+E FG + ++ A D + E + E A K+ ++ EL EL+++R V T+
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQH----EIEELNRELEEMR-VTYGTEG- 189
Query: 139 NERLASVAQELKEINQNVEIQRG---RLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
Q+L+E ++ + G +L ++++ + + ++++ EL E++ LQ Q
Sbjct: 190 -------LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242
Query: 196 SVLRQNQV-----------EFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ---LE 241
L+ ++ + K +I +++ E + LED + KE Q L+
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 242 EALETLKTEREQK--NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--- 296
E ++ + E+++K NS ++E+ +I + T + L+ D +
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 297 -EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
E +V + KL L N ++ S + L+ + E+QK + Q
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQ------SSEEIKQLMG--TVEELQKRNHKDSQF 414
Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQ-EKVTRLTENLSALRRLQASKERQTALDNEK 414
E + + Q+TQ++LE R L E +++ ++ + L +R+ A E K
Sbjct: 415 ETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKT--RHK 468
Query: 415 DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY 474
+ Y + +N +I +VA+ E + + + + EEK
Sbjct: 469 GEMENALRSYSNITVNEDQIKLM--NVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 475 EAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQD---ELVTFS 531
+ + + L E++S + ++ R+ +A E +L E SLS +D E+V+ S
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLN-------EAHKSLSTVEDLKAEIVSAS 579
Query: 532 EELANL-YHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
E L H N ML+ +E R + E R+ +L
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMAESQEA--ELERLRTQLLF---- 631
Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTT 649
S S L L R +NI L +D + H + +D
Sbjct: 632 --------------SHEEELSKLKEDLEIEHR--INIEKL----KDNLGIHYKQQIDGLQ 671
Query: 650 ELSRQRIASQELGPAVDKD-----KEALMEEILKLK----SLLSTKREQITTLRTVLKAN 700
Q+I + + +KD + L+ EI KLK SL+++K E++T L+ N
Sbjct: 672 NEMSQKIETMQF----EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT-----LQIN 722
Query: 701 KQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMFATRCDEYIT 759
+ E+ + + K EK + + + +L+ + + L K+ + L+ FA
Sbjct: 723 ELQKEIEILRQEEK---EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA-------- 771
Query: 760 QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
+++ + + +DEKKTL +L+ I ++ +RL L+
Sbjct: 772 ---QLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLD 807
Score = 60.5 bits (145), Expect = 6e-09
Identities = 171/885 (19%), Positives = 340/885 (38%), Gaps = 154/885 (17%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK--HQLK 58
+ A ++ + R ++ Q E ++AE + +L + T EK+ + + EK L+
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 59 LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESASKEQ 112
Q + LE+D E S +L++ + +T + ++ E+ L + E A +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE 2077
Query: 113 Y----YVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVE---IQRGRLRD 165
+ + +++ +L+ +LK + ++ + + +A LKE + + +L+
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137
Query: 166 DIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY-LNS 224
DI+E ++ +LE L++ + V + E KH +E + E L
Sbjct: 2138 DIQERN-------EEIEKLEFRVRELEQALLVSADTFQKVEDRKH-FGAVEAKPELSLEV 2189
Query: 225 QLE---DAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL-HVSL 280
QL+ DAI KE LEE LE + E E KN ++L + I T+ L +
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQ 2249
Query: 281 DGLKFSDDAAEPN---NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
+ F DD + +++A+ +H K +KE V+ L
Sbjct: 2250 ENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKF----AQIIQEKEVEIDQLNEQVTKLQ 2305
Query: 338 SELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSAL 397
+L I+ K+ ++ ++ R+ + L Q+ ++ R +E++ +L E + L
Sbjct: 2306 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR------EEEIEQLNEVIEKL 2359
Query: 398 RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
++ A+ ++T+++ H EA L+ QL +
Sbjct: 2360 QQELANIGQKTSMN---------------------------AHSLSEEADSLKHQLDVVI 2392
Query: 458 STHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDREL---LARLEKELKKVSDVAG 514
+ A E Q E + +T ++L++ + + +L L L++E + V +
Sbjct: 2393 AEKLALEQQ-------VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2445
Query: 515 ETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTS 574
+ S++VA D L EL V + + + Y++ S
Sbjct: 2446 IPENSVNVAIDHLSKDKPEL-----EVVLTEDALKSLENQTYFK---------------S 2485
Query: 575 PEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE--------PMN 626
E G+ S I L LL E+ T + + + D + +
Sbjct: 2486 FEENGKGSIINLETRLLQLES------TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Query: 627 IYNLIAIIRDQIKHL---QAAVDRTTELSR-----QRIASQELGPAVDK----DKEALME 674
I NL I+ +++ Q ++ E ++ Q I+S+ + ++ L
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
Query: 675 EILKLKSLLSTKREQITTLRTVLKANKQTAEVALANL------------------KSKYE 716
+I L +S Q+ + T L K+ E+A N+ K + E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
Query: 717 NEKAMVTE--TMMKLRNELKALKEDAATFSSLRAM----FATRCD--EYITQLDEMQRQL 768
EK + ++K EL E++ F+ L A+ AT+ + Y + +++Q +L
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2719
Query: 769 AAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
E +L L ++L +LE + E + KA
Sbjct: 2720 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2764
Score = 51.2 bits (121), Expect = 4e-06
Identities = 91/406 (22%), Positives = 158/406 (38%), Gaps = 43/406 (10%)
Query: 65 EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRKVLELQT 123
+ D ++ SE++ L A N +K+ E E QE Q ++LE+Q
Sbjct: 3084 KADRRSLLSEIQAL-----HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
Query: 124 ELKQLRNVLTNTQ----SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
EL +++ T Q SE +A + EL + +E +KE + +
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
E+ N +L + R+ Q E K ++ R EE + L+ ++ ++ Q
Sbjct: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
Query: 240 LEEALETLK---TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
L LE K E +QK ++ L + L V L+ K D
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
Query: 297 EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK---LKQQLM 353
E ++ A+L + T + PP PS DLL EL +K + + L
Sbjct: 3319 ERELH-------AQLQSSDGTGQSR-----PPLPS--EDLLKELQKQLEEKHSRIVELLN 3364
Query: 354 QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-KERQTALDN 412
+ E+ K L T Q +K + R +L +QE TE + LQ+ ++ Q L+
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE---ANTEGQKKMHELQSKVEDLQRQLEE 3421
Query: 413 EKDRDSHEDGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKAL 456
++ + Y++D+ G + + ++ E E RE + L
Sbjct: 3422 KRQQ-------VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3460
Score = 48.5 bits (114), Expect = 2e-05
Identities = 119/531 (22%), Positives = 204/531 (38%), Gaps = 82/531 (15%)
Query: 23 RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
+ E K LS EL E +E + + + E K + I EM + F
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL-----------TISEEMFSKDKTF 1559
Query: 83 GQAHTNHKKVAADGESREESLIQESASKE---QYYVRKVLELQTELKQLRNV-LTNTQSE 138
+ H +++ L+ E Q VR+ E Q + LR + + +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE------------ 186
E + +E+K +N+ + QR + D+ RE LL++ L++
Sbjct: 1620 REDQEQLQEEIKRLNRQLA-QRSSI-DNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677
Query: 187 -ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL--EDAIRLKEISERQLEEA 243
N S Q Q Q +VE + K K L+ + E + ++ + L++ + R L+
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKE--KELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
Query: 244 LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
LE +KT + ++ + H + I D S SL ++AEA V
Sbjct: 1736 LEVVKTTAAVEETIGR---HVLGILDRSSKSQSSASLIW----------RSEAEASVKSC 1782
Query: 304 EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
H ++ S P G P + ++ S++ E +L Q+L+ ++G
Sbjct: 1783 VHEEHTRV---TDESIPSYSGSDMPRNDI--NMWSKVT-EEGTELSQRLV-----RSGFA 1831
Query: 364 ATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDG 422
T D + + E S Q V +L E +S +L+ +K QT L E R E
Sbjct: 1832 GTEIDPENE-ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-- 1888
Query: 423 DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
E L C+ ELRE+L ARE Q A E + E
Sbjct: 1889 --------ATESLKCQE--------ELRERL---HEESRARE-QLAVELSKAEGVIDGYA 1928
Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
++ +L E+ ++ +++ RLE+EL S+ E + Q+E S +
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
Score = 47.4 bits (111), Expect = 6e-05
Identities = 104/490 (21%), Positives = 201/490 (41%), Gaps = 92/490 (18%)
Query: 5 SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-----HQLKL 59
S+ EE + E Q E E+ R + T +++Q + +LE++ + L+
Sbjct: 712 SKSEEMTLQINELQKE---IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQ----ESASKEQYYV 115
+F +LE + ++ E + L++ + HT S+EE LI +S SK+ +
Sbjct: 769 KFAQLEAENSILKDEKKTLEDML-KIHTP--------VSQEERLIFLDSIKSKSKDSVWE 819
Query: 116 RKV---LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-----RLRDDI 167
+++ +E +LKQ L + S A++ E+N E+Q +++DD+
Sbjct: 820 KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQEEYACLLKVKDDL 878
Query: 168 KEYKFREA-------RLLQDYSELEEENISLQKQVSVLRQNQVEF--------EGLKHEI 212
++ K ++ + L + L+ N + K S + F E ++ +
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
Query: 213 KRLEEETEYLNSQ-LEDAIRLKEISERQ---------LEEALETLKTEREQKNSLRKEL- 261
L E+ E + LE + RL ++SE+ L E +++LK E+EQ + +EL
Sbjct: 939 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Query: 262 ---SHYMSINDSFYTSHLHVSLDGL-----------------KFSDDA---AEPNNDAEA 298
+H + N + + LDG+ F +++ E E
Sbjct: 999 IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058
Query: 299 LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
+ G E +L LD+ S K+ L PS L ELN+ + ++ +L QME +
Sbjct: 1059 MTVG-EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL-QMEAQ 1116
Query: 359 KAGLLATLQDTQKQL------EHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
+ L Q+ E + S ++E + E + L+++ Q L
Sbjct: 1117 RICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-----HQLELQT 1171
Query: 413 EKDRDSHEDG 422
K +++ ++G
Sbjct: 1172 MKTQETGDEG 1181
Score = 45.4 bits (106), Expect = 2e-04
Identities = 155/785 (19%), Positives = 291/785 (37%), Gaps = 130/785 (16%)
Query: 57 LKLQFEEL-----EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE 111
+KL+F E E ++ +I S+M L++ NHK + + E++ ++E
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDI----DVNHKSKLSSLQDLEKTKLEEQVQ-- 1341
Query: 112 QYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR---DDIK 168
EL+ L ++S+ Q+LKE QN E + L+ +
Sbjct: 1342 ------------ELESL-------------ISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376
Query: 169 EYKFREARLLQDYSELEEENISLQKQVSVLRQN---QVEFE---GLKHEIKRLEEETEYL 222
E + + E + S +++N +EF G+K E ++ +
Sbjct: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY 1436
Query: 223 NSQLEDAIRLKEIS-ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
QLE+ + +S + E + ++N+ + +H + + Y + + +S D
Sbjct: 1437 QEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQD 1496
Query: 282 GLKFSD----DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
+ F D EHG ++ L N S P P S V +
Sbjct: 1497 QIGFQTFETVDVKFKEEFKPLSKELGEHG--KEILLSN--SDPHD---IPESKDCVLTIS 1549
Query: 338 SELNISEIQKLKQQLMQMEREKAGLLAT--LQDTQKQLEHTRGSLSEQQEKVTRLTENL- 394
E+ + + +Q + E + + A+ L ++QLE R L Q ++ + TE L
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 395 -SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQL 453
+ +R+++ +E Q L E R + + +D ++ L E+L
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID---------NENLVSERERVLLEEL 1660
Query: 454 KALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVA 513
+AL+ A + E + Q E +E+ + +++EL + E ++
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE---DVPPEIL 1717
Query: 514 GETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRT 573
+ +L A + L+ E+ V ET R +L S R+
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAV----EETIGRHVLGILDRSSKSQSSASLIWRS 1773
Query: 574 SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS-PGSSLPSPLSDPRREPMNIYNLIA 632
EA K + E R T +S PS GS +P
Sbjct: 1774 EAEAS--------VKSCVHEEHTRV---TDESIPSYSGSDMP------------------ 1804
Query: 633 IIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
R+ I + TELS++ + S G +D + E LM L + S L E++
Sbjct: 1805 --RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELM---LNISSRLQAAVEKLLE 1859
Query: 693 LRTVLKANKQTAEVALANLKSKYENEKAMVTETMM-------KLRNELKALKEDAATFSS 745
+ + + A+V L + +K TE++ +L E +A ++ A S
Sbjct: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSK 1919
Query: 746 LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
+ D Y + +RQ+ ++KT ++ Q+ L + RL+ LE + +Q
Sbjct: 1920 AEGVI----DGYADEKTLFERQI-----QEKT--DIIDRLEQELLCASNRLQELEAEQQQ 1968
Query: 806 TRRGR 810
+ R
Sbjct: 1969 IQEER 1973
Score = 44.3 bits (103), Expect = 5e-04
Identities = 168/815 (20%), Positives = 303/815 (37%), Gaps = 117/815 (14%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
E L+ E+KRL+ +LA+ R I ++ E+ ++ L EELE + + E+L
Sbjct: 1624 EQLQEEIKRLNRQLAQ--RSSIDNEN----LVSERERVLL--EELEALKQLSLAGREKLC 1675
Query: 80 EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
+ + + ++E KE+ RK ++ E+ L N Q N
Sbjct: 1676 -----CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYALQKAN 1728
Query: 140 ERLASVAQELKEINQNVEIQRGR----LRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
RL + E+ + VE GR + D + + + + + +E ++ ++
Sbjct: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
Query: 196 SVLRQNQVEFEGL---KHEI----KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
V ++ + G +++I K EE TE + EI E L
Sbjct: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
Query: 249 TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGL 308
+ L + +S S + + + + + +A E E L
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
Query: 309 AKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKLKQQLMQMEREKAGLLA 364
A+ L + S K EG+ L E I E I +L+Q+L+ L
Sbjct: 1909 AREQLAVELS--KAEGVIDGYAD--EKTLFERQIQEKTDIIDRLEQELLCASNR----LQ 1960
Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
L+ Q+Q++ R LS Q+E A++ E+Q + EK +
Sbjct: 1961 ELEAEQQQIQEERELLSRQKE----------AMKAEAGPVEQQLLQETEKLMK-----EK 2005
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY-EAEGQALTE 483
EV ++ +L++Q+KAL E E+ R+ E E + TE
Sbjct: 2006 LEVQCQAEKV-----------RDDLQKQVKAL-------EIDVEEQVSRFIELEQEKNTE 2047
Query: 484 KVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCM 543
+ L +Q++ L +LEK K + + A + + V Q E+ ++L + +
Sbjct: 2048 LMDL----RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI 2103
Query: 544 CNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTG 603
++T RE + A E + S +LL K L + +
Sbjct: 2104 SEHQT---------REVEQLANHLK-------EKTDKCSELLLSKEQLQRDIQERN---- 2143
Query: 604 DSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGP 663
L + + + + + + D+ KH AV+ ELS + E
Sbjct: 2144 ----EEIEKLEFRVRELEQALLVSADTFQKVEDR-KHF-GAVEAKPELSLEVQLQAERDA 2197
Query: 664 AVDKDKEA--LMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAM 721
K+KE L E++ + + L K E++ L L+ K+ + L L E E +
Sbjct: 2198 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL----EQENKL 2253
Query: 722 VTETMMKLRNELKALKEDAATFSS----LRAMFATRCDEYITQLDEMQRQLAAAEDEKK- 776
+ M KL A+KE A + L FA E ++D++ Q+ + + K
Sbjct: 2254 FKDDMEKLG---LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2310
Query: 777 -TLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
T N ++ + L ++E L D E +R R
Sbjct: 2311 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2345
Score = 35.8 bits (81), Expect = 0.17
Identities = 63/270 (23%), Positives = 108/270 (40%), Gaps = 57/270 (21%)
Query: 5 SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
++E YA+L+ + +HEL E R+K+Q L VL +K +LQFE
Sbjct: 3490 TKESNYAKLIE------MNGGGTGCNHEL-EMIRQKLQCVASKLQVLPQKASERLQFETA 3542
Query: 65 EVD-----YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQES---ASKEQYYVR 116
+ + E I + QL++ GQ + E SL+ S S + +R
Sbjct: 3543 DDEDFIWVQENIDEIILQLQKLTGQ------------QGEEPSLVSPSTSCGSLTERLLR 3590
Query: 117 KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR--- 173
+ EL + QL T+ +N+ L ++ +L+E + Q G RD+ +
Sbjct: 3591 QNAELTGHISQL------TEEKND-LRNMVMKLEEQIRWYR-QTGAGRDNSSRFSLNGGA 3642
Query: 174 --EARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
EA + + E ++LQK +KR E E L ++L +
Sbjct: 3643 NIEAIIASEKEVWNREKLTLQK-----------------SLKRAEAEVYKLKAELRNDSL 3685
Query: 232 LKEISERQLEEALETLKTEREQKNSLRKEL 261
L+ +S L+ + + + S RK L
Sbjct: 3686 LQTLSPDSEHVTLKRIYGKYLRAESFRKAL 3715
Score = 35.4 bits (80), Expect = 0.22
Identities = 73/411 (17%), Positives = 177/411 (43%), Gaps = 48/411 (11%)
Query: 125 LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
+ L++++T Q + E + + + +++ RG L +++ E +L
Sbjct: 2991 ISSLKDLITKMQLQRE---AEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3047
Query: 185 EEENISLQKQVSVLR--QNQVEFEGLKHEI----------KRLEEETEYLNSQLED---A 229
E + V +L + +++ +G++++ + L E + L++Q+
Sbjct: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107
Query: 230 IRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL---KF 285
++ ++ SE+ +E LE ++ ++ Q ++ ELS S+ D +S + + +
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMVVAEL 3164
Query: 286 SDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI 345
+ A+ + E + +H L +L K + + LL++ SE
Sbjct: 3165 KSELAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV---------HLLNDTLASEQ 3214
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K ++ +E+EKA L + + +++LE + SL Q+++ +L NL ++ Q E
Sbjct: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL--NLLLEQQKQLLNE 3272
Query: 406 RQTALDNEK----DRDSHEDGDYYEVDI--NGPEILACKYHVAVAEAGELREQLKALRST 459
Q +++++ + S E G E+ + ++ + + EL QL++ T
Sbjct: 3273 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3332
Query: 460 HEAREAQHAEE-----KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
++R +E+ + + E + + E ++ EK + ++EK+
Sbjct: 3333 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383
Score = 34.7 bits (78), Expect = 0.37
Identities = 45/215 (20%), Positives = 92/215 (42%), Gaps = 46/215 (21%)
Query: 51 LEEKH----QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQE 106
LEEKH +L + E+ ++D R +ME+ ++ + ++ +G+ + L
Sbjct: 3352 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS- 3410
Query: 107 SASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD 166
KV +LQ +L++ R + E +RL + QE Q E++R R+
Sbjct: 3411 ----------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF----QKQELEREEKRES 3456
Query: 167 IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE-----------------GLK 209
L Q+ +E +++ + + + Q ++E E G
Sbjct: 3457 -------RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCN 3509
Query: 210 HEIKRLEEETEYLNSQLEDAIRLKEISER-QLEEA 243
HE++ + ++ + + S+L+ + ++ SER Q E A
Sbjct: 3510 HELEMIRQKLQCVASKLQ--VLPQKASERLQFETA 3542
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 80.1 bits (196), Expect = 8e-15
Identities = 109/546 (19%), Positives = 223/546 (40%), Gaps = 68/546 (12%)
Query: 2 SAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQF 61
S E +E ++ E + + E K L + TT +K+ E ++++ ++K
Sbjct: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL-LGELQEQIVQKNQEIKNMK 377
Query: 62 EELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLEL 121
EL + R E++K+ G K+ D + E ++Q + Q RK+ +L
Sbjct: 378 LELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF-ETDIVQRMEQETQ---RKLEQL 433
Query: 122 QTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDY 181
+ EL ++ Q + + Q + ++ + +G + + ++ Y + + +
Sbjct: 434 RAELDEMYG----QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY----SNITVNE 485
Query: 182 SELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLE 241
+++ N+++ + L+ + E LK E+ + EE L QLED + S Q++
Sbjct: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545
Query: 242 EALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVN 301
A +T+ + + N K LS + ++ S+ E EA V
Sbjct: 546 RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA-----------SESRKELELKHEAEVT 594
Query: 302 GFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAG 361
++ KL + K + +A + + L ++L S ++L + +E E
Sbjct: 595 NYK----IKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI 650
Query: 362 LLATLQDT-----QKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDR 416
+ L+D ++Q++ + +S++ E + +NL +K+ Q L+ K +
Sbjct: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNL-------ITKQNQLILEISKLK 703
Query: 417 DSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
D + ++ K + EL+++++ LR Q +EKG E
Sbjct: 704 DLQQS------------LVNSKSEEMTLQINELQKEIEILR--------QEEKEKGTLEQ 743
Query: 477 EGQALTEKVSLLEKASRQD----RELLARLEKELKKVSDVAGETQGSLS----VAQDELV 528
E Q L K LLEK ++ +E A+LE E + D + L V+Q+E +
Sbjct: 744 EVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 529 TFSEEL 534
F + +
Sbjct: 804 IFLDSI 809
Score = 69.7 bits (169), Expect = 1e-11
Identities = 148/766 (19%), Positives = 320/766 (41%), Gaps = 82/766 (10%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
V E Q + + + L+ +L +T +K + E +LEEK L+ Q E+L + R
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 74 EMEQLKEAFGQAHTN----HK----------KVAADGESREESLIQESASKEQYYVRKVL 119
++++ ++ + + HK ++ + ESR+E ++ A Y ++ +
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM 602
Query: 120 ELQTELKQLRNVLTNTQSENERLA-----SVAQELKEINQNVEIQR----GRLRDDIKEY 170
+ + L + + ++E ERL S +EL ++ +++EI+ +L+D++ +
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662
Query: 171 KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE-ETEYLNSQLEDA 229
++ LQ+ + E + +K + +QNQ L EI +L++ + +NS+ E+
Sbjct: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ-----LILEISKLKDLQQSLVNSKSEE- 716
Query: 230 IRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL--KFSD 287
+ +L++ +E L+ E ++K +L +E+ + + + + L KF+
Sbjct: 717 ---MTLQINELQKEIEILRQEEKEKGTLEQEVQE-LQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 288 DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK 347
AE N+ + E P+ + + + S V + E+ I E +
Sbjct: 773 LEAE-NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 348 LKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQ 407
LKQQ +Q+ E T +K E L E+ + ++ ++ L+ SK +Q
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDD------LEDSKNKQ 885
Query: 408 TALDNEKDRDSHEDGDYYEVDINGPEILACKY---HVAVAEAGELREQLKALRSTHEARE 464
K + +E+ ++ ++ + + VAE E+ E ++ + T E E
Sbjct: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--KDTTELME 943
Query: 465 AQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQ 524
++ + E L++++S L + +Q ++ L +E+K + + Q SL +
Sbjct: 944 KLEVTKREKLE-----LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ--EKEQVSLRCRE 996
Query: 525 DELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPI 584
E++ N V C+ + + + +G G S ++ G S I
Sbjct: 997 LEIIINHNRAEN----VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF----GEESKI 1048
Query: 585 LLP-----KGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK 639
++ + + E + + D PS + P E + + +++ +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP-SENDKLQKELNVLKSEQN 1107
Query: 640 HLQAAVDRTTELSRQRIA-SQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLK 698
L+ ++ QRI S VD+ +E + E K K+L S K E I +K
Sbjct: 1108 DLR------LQMEAQRICLSLVYSTHVDQVREYMENE--KDKALCSLKEELIFAQEEKIK 1159
Query: 699 ANKQTAEVALANLKSKYENEKAMVTETMM-KLRNELKALKEDAATF 743
++ ++ L +K++ ++ ++ KL+ KA+ E+ + F
Sbjct: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ---KAVSEECSYF 1202
Score = 68.9 bits (167), Expect = 2e-11
Identities = 151/811 (18%), Positives = 341/811 (42%), Gaps = 98/811 (12%)
Query: 26 VKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIR-----SEMEQLKE 80
+ +L+ L + REK + L + E+ +L++QF++L+ E +R S L +
Sbjct: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSSTAADLLQ 265
Query: 81 AFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT-----ELKQLRNVLTNT 135
A Q T+ +++ ++ L+++ K++ + ++ LQ E++Q + V +
Sbjct: 266 AKQQILTHQQQL-----EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320
Query: 136 QSENERLASVAQEL-----KEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENIS 190
+ E + ++ +EL +E + +E+ + +L K + +++Q E++ +
Sbjct: 321 KEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTTADKLLGELQEQIVQKNQEIKNMKLE 379
Query: 191 LQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAI--RLKEISERQLEEALETL- 247
L RQ+ E + L ++ L++ + +SQ E I R+++ ++R+LE+ L
Sbjct: 380 LTNSKQKERQSSEEIKQLMGTVEELQKR-NHKDSQFETDIVQRMEQETQRKLEQLRAELD 438
Query: 248 KTEREQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
+ +Q +++EL +M+ + T H + L+ S N D L+N
Sbjct: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-SYSNITVNEDQIKLMN----V 493
Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATL 366
+ +L + + + +KE L E+ + ++ ++R+ L+ L
Sbjct: 494 AINELNIKLQDTNSQKEKLK----------------EELGLILEEKCALQRQLEDLVEEL 537
Query: 367 QDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY-- 424
+++Q++ R +++EQ+ K+ ++LS + L+A E +A ++ K+ + + +
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTN 595
Query: 425 --YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
++++ E A +A ++ EL L +HE ++ E+ E E +
Sbjct: 596 YKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED---LEIEHRINI 652
Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVC 542
EK L + ++ + L+ E+ + + + +L Q++L+ +L +L +
Sbjct: 653 EK--LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710
Query: 543 MCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGT 602
+E + + +E + G E + + L LL + +
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ----ELQLKTELLEKQMKEKE--- 763
Query: 603 GDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQR------- 655
+D + + + +I++D+ K L+ + T +S++
Sbjct: 764 ---------------NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808
Query: 656 IASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKY 715
I S+ +K+ E L+EE LK E+I R ++ EV L+ +Y
Sbjct: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868
Query: 716 -------ENEKAMVTETMMKLRNELKALKED---AATFSSLRAMFATRCDEYITQLDEMQ 765
++ + + ++ +++LKAL E+ + M ++ DE T + E
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928
Query: 766 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRL 796
E + L L + ++KL L+QRL
Sbjct: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRL 959
Score = 62.4 bits (150), Expect = 2e-09
Identities = 174/882 (19%), Positives = 337/882 (38%), Gaps = 156/882 (17%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK--HQLK 58
+ A ++ + R ++ Q E ++AE + +L + T EK+ + + EK L+
Sbjct: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 59 LQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESASKEQ 112
Q + LE+D E S +L++ + +T + ++ E+ L + E A +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQ---EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE 2077
Query: 113 Y----YVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIK 168
+ + +++ +L+ +LK + ++ + + +A LKE D
Sbjct: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKT-----------DKCS 2126
Query: 169 EYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEY-LNSQLE 227
E + +L +D E EE L+ +V L Q + E KH +E + E L QL+
Sbjct: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL-VEDRKH-FGAVEAKPELSLEVQLQ 2184
Query: 228 ---DAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHL-HVSLDGL 283
DAI KE LEE LE + E E KN ++L + I T+ L + +
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2244
Query: 284 KFSDDAAEPN---NDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL 340
F DD + +++A+ +H K +KE V+ L +L
Sbjct: 2245 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKF----AQIIQEKEVEIDQLNEQVTKLQQQL 2300
Query: 341 NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRL 400
I+ K+ ++ ++ R+ + L Q+ ++ R +E++ +L E + L++
Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR------EEEIEQLNEVIEKLQQE 2354
Query: 401 QASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH 460
A+ ++T+++ H EA L+ QL + +
Sbjct: 2355 LANIGQKTSMN---------------------------AHSLSEEADSLKHQLDVVIAEK 2387
Query: 461 EAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDREL---LARLEKELKKVSDVAGETQ 517
A E Q E + +T ++L++ + + +L L L++E + V + +
Sbjct: 2388 LALEQQ-------VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE 2440
Query: 518 GSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEA 577
S++VA D L EL V + + + Y++ S E
Sbjct: 2441 NSVNVAIDHLSKDKPEL-----EVVLTEDALKSLENQTYFK---------------SFEE 2480
Query: 578 RGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRRE--------PMNIYN 629
G+ S I L LL E+ T + + + D + + I N
Sbjct: 2481 NGKGSIINLETRLLQLES------TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2534
Query: 630 LIAIIRDQIKHL---QAAVDRTTELSR-----QRIASQELGPAVDK----DKEALMEEIL 677
L I+ +++ Q ++ E ++ Q I+S+ + ++ L +I
Sbjct: 2535 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS 2594
Query: 678 KLKSLLSTKREQITTLRTVLKANKQTAEVALANL------------------KSKYENEK 719
L +S Q+ + T L K+ E+A N+ K + E EK
Sbjct: 2595 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2654
Query: 720 AMVTE--TMMKLRNELKALKEDAATFSSLRAM----FATRCD--EYITQLDEMQRQLAAA 771
+ ++K EL E++ F+ L A+ AT+ + Y + +++Q +L
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK 2714
Query: 772 EDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
E +L L ++L +LE + E + KA
Sbjct: 2715 ETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2756
Score = 61.2 bits (147), Expect = 4e-09
Identities = 118/551 (21%), Positives = 233/551 (42%), Gaps = 79/551 (14%)
Query: 9 EYARLVMEAQPE--WLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEV 66
++A+++ E + E L +V +L +L TT K V+EEK++L +LE
Sbjct: 2274 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK---------VIEEKNEL---IRDLET 2321
Query: 67 DYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELK 126
E + S+ E +K N ++ E L QE A+ Q L E
Sbjct: 2322 QIECLMSDQECVKR-------NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374
Query: 127 QLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE 186
L++ L +E ++ Q+++ N+ + +++ +KE F+ +L Q+ L+
Sbjct: 2375 SLKHQLDVVIAEK---LALEQQVETANEEMTF----MKNVLKETNFKMNQLTQELFSLKR 2427
Query: 187 ENISLQKQVSV-----------LRQNQVEFEGLKHE--IKRLEEETEYLNSQLEDAIRLK 233
E S++K S+ L +++ E E + E +K LE +T + + + +
Sbjct: 2428 ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSII 2487
Query: 234 EISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAE 291
+ R QLE + E Q K++ F T L + L+
Sbjct: 2488 NLETRLLQLESTVSAKDLELTQCYKQIKDMQE----QGQFETEMLQKKIVNLQ----KIV 2539
Query: 292 PNNDAEALVNGFEHGGL---AKLPLDNKT--STPKKEGLAPPSPSLVSDLLSELNISEIQ 346
A ALV+ + + AK DN+T S P++ + ++ L + S+I
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-----LNQLREDELGSDIS 2594
Query: 347 KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKER 406
L ++ ++E + + +L ++Q+E ++ E+++K+ L + L + Q KE+
Sbjct: 2595 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2654
Query: 407 QTA--------LDNEKDRDSHEDGDYYEVDINGPEILACKYHVA--VAEAGELREQLKAL 456
+ + E + E G + E++ E +A K +A +A +L+E+L +
Sbjct: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL-LV 2713
Query: 457 RSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASR---QDRELLARLEK-ELKKVSDV 512
+ T+ + + + AE + EK+S+LEK Q+ + E +K +
Sbjct: 2714 KETNMTSLQKDLSQVRDHLAEAK---EKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2770
Query: 513 AGETQGSLSVA 523
A +T G+L ++
Sbjct: 2771 ASQTDGTLKIS 2781
Score = 60.5 bits (145), Expect = 6e-09
Identities = 158/761 (20%), Positives = 308/761 (40%), Gaps = 128/761 (16%)
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
+E FG + ++ A D + E + E A K+ ++ EL EL+++R V T+
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQH----EIEELNRELEEMR-VTYGTEG- 189
Query: 139 NERLASVAQELKEINQNVEIQRG---RLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
Q+L+E ++ + G +L ++++ + + ++++ EL E++ LQ Q
Sbjct: 190 -------LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF 242
Query: 196 SVLRQNQV-----------EFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ---LE 241
L+ ++ + K +I +++ E + LED + KE Q L+
Sbjct: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302
Query: 242 EALETLKTEREQK--NSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA--- 296
E ++ + E+++K NS ++E+ +I + T + L+ D +
Sbjct: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362
Query: 297 -EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM 355
E +V + KL L N ++ S + L+ + E+QK + Q
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQ------SSEEIKQLMG--TVEELQKRNHKDSQF 414
Query: 356 EREKAGLLATLQDTQKQLEHTRGSLSEQQ-EKVTRLTENLSALRRLQASKERQTALDNEK 414
E + + Q+TQ++LE R L E +++ ++ + L +R+ A E K
Sbjct: 415 ETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKT--RHK 468
Query: 415 DRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY 474
+ Y + +N +I +VA+ E + + + + EEK
Sbjct: 469 GEMENALRSYSNITVNEDQIKLM--NVAINELNIKLQDTNSQKEKLKEELGLILEEKCAL 526
Query: 475 EAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQD---ELVTFS 531
+ + + L E++S + ++ R+ +A E +L E SLS +D E+V+ S
Sbjct: 527 QRQLEDLVEELSFSREQIQRARQTIAEQESKLN-------EAHKSLSTVEDLKAEIVSAS 579
Query: 532 EELANL-YHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGL 590
E L H N ML+ +E R + E R+ +L
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMAESQEA--ELERLRTQLLF---- 631
Query: 591 LAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIK-HLQAAVDRTT 649
S S L L R +NI L +D + H + +D
Sbjct: 632 --------------SHEEELSKLKEDLEIEHR--INIEKL----KDNLGIHYKQQIDGLQ 671
Query: 650 ELSRQRIASQELGPAVDKD-----KEALMEEILKLK----SLLSTKREQITTLRTVLKAN 700
Q+I + + +KD + L+ EI KLK SL+++K E++T L+ N
Sbjct: 672 NEMSQKIETMQF----EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT-----LQIN 722
Query: 701 KQTAEVALANLKSKYENEKAMVTETMMKLRNELKAL-KEDAATFSSLRAMFATRCDEYIT 759
+ E+ + + K EK + + + +L+ + + L K+ + L+ FA
Sbjct: 723 ELQKEIEILRQEEK---EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA-------- 771
Query: 760 QLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLE 800
+++ + + +DEKKTL +L+ I ++ +RL L+
Sbjct: 772 ---QLEAENSILKDEKKTLEDMLK--IHTPVSQEERLIFLD 807
Score = 51.2 bits (121), Expect = 4e-06
Identities = 91/406 (22%), Positives = 158/406 (38%), Gaps = 43/406 (10%)
Query: 65 EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE-QYYVRKVLELQT 123
+ D ++ SE++ L A N +K+ E E QE Q ++LE+Q
Sbjct: 3076 KADRRSLLSEIQAL-----HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130
Query: 124 ELKQLRNVLTNTQ----SENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQ 179
EL +++ T Q SE +A + EL + +E +KE + +
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3190
Query: 180 DYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQ 239
E+ N +L + R+ Q E K ++ R EE + L+ ++ ++ Q
Sbjct: 3191 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3250
Query: 240 LEEALETLK---TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDA 296
L LE K E +QK ++ L + L V L+ K D
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3310
Query: 297 EALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQK---LKQQLM 353
E ++ A+L + T + PP PS DLL EL +K + + L
Sbjct: 3311 ERELH-------AQLQSSDGTGQSR-----PPLPS--EDLLKELQKQLEEKHSRIVELLN 3356
Query: 354 QMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQAS-KERQTALDN 412
+ E+ K L T Q +K + R +L +QE TE + LQ+ ++ Q L+
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQE---ANTEGQKKMHELQSKVEDLQRQLEE 3413
Query: 413 EKDRDSHEDGDYYEVDINGPEI--LACKYHVAVAEAGELREQLKAL 456
++ + Y++D+ G + + ++ E E RE + L
Sbjct: 3414 KRQQ-------VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL 3452
Score = 48.5 bits (114), Expect = 2e-05
Identities = 119/531 (22%), Positives = 204/531 (38%), Gaps = 82/531 (15%)
Query: 23 RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82
+ E K LS EL E +E + + + E K + I EM + F
Sbjct: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL-----------TISEEMFSKDKTF 1559
Query: 83 GQAHTNHKKVAADGESREESLIQESASKE---QYYVRKVLELQTELKQLRNV-LTNTQSE 138
+ H +++ L+ E Q VR+ E Q + LR + + +
Sbjct: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEE------------ 186
E + +E+K +N+ + QR + D+ RE LL++ L++
Sbjct: 1620 REDQEQLQEEIKRLNRQLA-QRSSI-DNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677
Query: 187 -ENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQL--EDAIRLKEISERQLEEA 243
N S Q Q Q +VE + K K L+ + E + ++ + L++ + R L+
Sbjct: 1678 LRNSSTQTQNGNENQGEVEEQTFKE--KELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
Query: 244 LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGF 303
LE +KT + ++ + H + I D S SL ++AEA V
Sbjct: 1736 LEVVKTTAAVEETIGR---HVLGILDRSSKSQSSASLIW----------RSEAEASVKSC 1782
Query: 304 EHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL 363
H ++ S P G P + ++ S++ E +L Q+L+ ++G
Sbjct: 1783 VHEEHTRV---TDESIPSYSGSDMPRNDI--NMWSKVT-EEGTELSQRLV-----RSGFA 1831
Query: 364 ATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDG 422
T D + + E S Q V +L E +S +L+ +K QT L E R E
Sbjct: 1832 GTEIDPENE-ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-- 1888
Query: 423 DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
E L C+ ELRE+L ARE Q A E + E
Sbjct: 1889 --------ATESLKCQE--------ELRERL---HEESRARE-QLAVELSKAEGVIDGYA 1928
Query: 483 EKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEE 533
++ +L E+ ++ +++ RLE+EL S+ E + Q+E S +
Sbjct: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979
Score = 47.4 bits (111), Expect = 6e-05
Identities = 104/490 (21%), Positives = 201/490 (41%), Gaps = 92/490 (18%)
Query: 5 SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEK-----HQLKL 59
S+ EE + E Q E E+ R + T +++Q + +LE++ + L+
Sbjct: 712 SKSEEMTLQINELQKE---IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQ----ESASKEQYYV 115
+F +LE + ++ E + L++ + HT S+EE LI +S SK+ +
Sbjct: 769 KFAQLEAENSILKDEKKTLEDML-KIHTP--------VSQEERLIFLDSIKSKSKDSVWE 819
Query: 116 RKV---LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRG-----RLRDDI 167
+++ +E +LKQ L + S A++ E+N E+Q +++DD+
Sbjct: 820 KEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ-ELQEEYACLLKVKDDL 878
Query: 168 KEYKFREA-------RLLQDYSELEEENISLQKQVSVLRQNQVEF--------EGLKHEI 212
++ K ++ + L + L+ N + K S + F E ++ +
Sbjct: 879 EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDT 938
Query: 213 KRLEEETEYLNSQ-LEDAIRLKEISERQ---------LEEALETLKTEREQKNSLRKEL- 261
L E+ E + LE + RL ++SE+ L E +++LK E+EQ + +EL
Sbjct: 939 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Query: 262 ---SHYMSINDSFYTSHLHVSLDGL-----------------KFSDDA---AEPNNDAEA 298
+H + N + + LDG+ F +++ E E
Sbjct: 999 IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN 1058
Query: 299 LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
+ G E +L LD+ S K+ L PS L ELN+ + ++ +L QME +
Sbjct: 1059 MTVG-EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL-QMEAQ 1116
Query: 359 KAGLLATLQDTQKQL------EHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN 412
+ L Q+ E + S ++E + E + L+++ Q L
Sbjct: 1117 RICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-----HQLELQT 1171
Query: 413 EKDRDSHEDG 422
K +++ ++G
Sbjct: 1172 MKTQETGDEG 1181
Score = 45.4 bits (106), Expect = 2e-04
Identities = 155/785 (19%), Positives = 291/785 (37%), Gaps = 130/785 (16%)
Query: 57 LKLQFEEL-----EVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKE 111
+KL+F E E ++ +I S+M L++ NHK + + E++ ++E
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDI----DVNHKSKLSSLQDLEKTKLEEQVQ-- 1341
Query: 112 QYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLR---DDIK 168
EL+ L ++S+ Q+LKE QN E + L+ +
Sbjct: 1342 ------------ELESL-------------ISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376
Query: 169 EYKFREARLLQDYSELEEENISLQKQVSVLRQN---QVEFE---GLKHEIKRLEEETEYL 222
E + + E + S +++N +EF G+K E ++ +
Sbjct: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY 1436
Query: 223 NSQLEDAIRLKEIS-ERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLD 281
QLE+ + +S + E + ++N+ + +H + + Y + + +S D
Sbjct: 1437 QEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQD 1496
Query: 282 GLKFSD----DAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLL 337
+ F D EHG ++ L N S P P S V +
Sbjct: 1497 QIGFQTFETVDVKFKEEFKPLSKELGEHG--KEILLSN--SDPHD---IPESKDCVLTIS 1549
Query: 338 SELNISEIQKLKQQLMQMEREKAGLLAT--LQDTQKQLEHTRGSLSEQQEKVTRLTENL- 394
E+ + + +Q + E + + A+ L ++QLE R L Q ++ + TE L
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 395 -SALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQL 453
+ +R+++ +E Q L E R + + +D ++ L E+L
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID---------NENLVSERERVLLEEL 1660
Query: 454 KALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVA 513
+AL+ A + E + Q E +E+ + +++EL + E ++
Sbjct: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE---DVPPEIL 1717
Query: 514 GETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRT 573
+ +L A + L+ E+ V ET R +L S R+
Sbjct: 1718 SNERYALQKANNRLLKILLEVVKTTAAV----EETIGRHVLGILDRSSKSQSSASLIWRS 1773
Query: 574 SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPS-PGSSLPSPLSDPRREPMNIYNLIA 632
EA K + E R T +S PS GS +P
Sbjct: 1774 EAEAS--------VKSCVHEEHTRV---TDESIPSYSGSDMP------------------ 1804
Query: 633 IIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITT 692
R+ I + TELS++ + S G +D + E LM L + S L E++
Sbjct: 1805 --RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELM---LNISSRLQAAVEKLLE 1859
Query: 693 LRTVLKANKQTAEVALANLKSKYENEKAMVTETMM-------KLRNELKALKEDAATFSS 745
+ + + A+V L + +K TE++ +L E +A ++ A S
Sbjct: 1860 AISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSK 1919
Query: 746 LRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQ 805
+ D Y + +RQ+ ++KT ++ Q+ L + RL+ LE + +Q
Sbjct: 1920 AEGVI----DGYADEKTLFERQI-----QEKT--DIIDRLEQELLCASNRLQELEAEQQQ 1968
Query: 806 TRRGR 810
+ R
Sbjct: 1969 IQEER 1973
Score = 45.1 bits (105), Expect = 3e-04
Identities = 168/816 (20%), Positives = 302/816 (37%), Gaps = 127/816 (15%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
E L+ E+KRL+ +LA+ R I ++ E+ ++ L EELE + + E+L
Sbjct: 1624 EQLQEEIKRLNRQLAQ--RSSIDNEN----LVSERERVLL--EELEALKQLSLAGREKLC 1675
Query: 80 EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
+ + + ++E KE+ RK ++ E+ L N Q N
Sbjct: 1676 -----CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI--LSNERYALQKAN 1728
Query: 140 ERLASVAQELKEINQNVEIQRGR----LRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
RL + E+ + VE GR + D + + + + + +E ++ ++
Sbjct: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
Query: 196 SVLRQNQVEFEGL---KHEI----KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
V ++ + G +++I K EE TE + EI E L
Sbjct: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
Query: 249 TEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGL 308
+ L + +S S + + + + + +A E E L
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
Query: 309 AKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISE----IQKLKQQLMQMEREKAGLLA 364
A+ L + S K EG+ L E I E I +L+Q+L+ L
Sbjct: 1909 AREQLAVELS--KAEGVIDGYAD--EKTLFERQIQEKTDIIDRLEQELLCASNR----LQ 1960
Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDY 424
L+ Q+Q++ R LS Q+E A++ E+Q + EK +
Sbjct: 1961 ELEAEQQQIQEERELLSRQKE----------AMKAEAGPVEQQLLQETEKLMK-----EK 2005
Query: 425 YEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRY-EAEGQALTE 483
EV ++ +L++Q+KAL E E+ R+ E E + TE
Sbjct: 2006 LEVQCQAEKV-----------RDDLQKQVKAL-------EIDVEEQVSRFIELEQEKNTE 2047
Query: 484 KVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCM 543
+ L +Q++ L +LEK K + + A + + V Q E+ ++L + +
Sbjct: 2048 LMDL----RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPI 2103
Query: 544 CNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTG 603
++T RE + A E + S +LL K L + +
Sbjct: 2104 SEHQT---------REVEQLANHLK-------EKTDKCSELLLSKEQLQRDIQERN---- 2143
Query: 604 DSSPSPGSSLPSPLSDPRREPMNIYNL-IAIIRDQIKHLQAAVDRTTELSRQRIASQELG 662
+ + + L A++ + KH AV+ ELS + E
Sbjct: 2144 --------------EEIEKLEFRVRELEQALLVEDRKHF-GAVEAKPELSLEVQLQAERD 2188
Query: 663 PAVDKDKEA--LMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720
K+KE L E++ + + L K E++ L L+ K+ + L L E E
Sbjct: 2189 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL----EQENK 2244
Query: 721 MVTETMMKLRNELKALKEDAATFSS----LRAMFATRCDEYITQLDEMQRQLAAAEDEKK 776
+ + M KL A+KE A + L FA E ++D++ Q+ + + K
Sbjct: 2245 LFKDDMEKLG---LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301
Query: 777 --TLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
T N ++ + L ++E L D E +R R
Sbjct: 2302 ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337
Score = 35.8 bits (81), Expect = 0.17
Identities = 63/270 (23%), Positives = 108/270 (40%), Gaps = 57/270 (21%)
Query: 5 SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEEL 64
++E YA+L+ + +HEL E R+K+Q L VL +K +LQFE
Sbjct: 3482 TKESNYAKLIE------MNGGGTGCNHEL-EMIRQKLQCVASKLQVLPQKASERLQFETA 3534
Query: 65 EVD-----YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQES---ASKEQYYVR 116
+ + E I + QL++ GQ + E SL+ S S + +R
Sbjct: 3535 DDEDFIWVQENIDEIILQLQKLTGQ------------QGEEPSLVSPSTSCGSLTERLLR 3582
Query: 117 KVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFR--- 173
+ EL + QL T+ +N+ L ++ +L+E + Q G RD+ +
Sbjct: 3583 QNAELTGHISQL------TEEKND-LRNMVMKLEEQIRWYR-QTGAGRDNSSRFSLNGGA 3634
Query: 174 --EARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIR 231
EA + + E ++LQK +KR E E L ++L +
Sbjct: 3635 NIEAIIASEKEVWNREKLTLQK-----------------SLKRAEAEVYKLKAELRNDSL 3677
Query: 232 LKEISERQLEEALETLKTEREQKNSLRKEL 261
L+ +S L+ + + + S RK L
Sbjct: 3678 LQTLSPDSEHVTLKRIYGKYLRAESFRKAL 3707
Score = 35.4 bits (80), Expect = 0.22
Identities = 73/411 (17%), Positives = 177/411 (43%), Gaps = 48/411 (11%)
Query: 125 LKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL 184
+ L++++T Q + E + + + +++ RG L +++ E +L
Sbjct: 2983 ISSLKDLITKMQLQRE---AEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039
Query: 185 EEENISLQKQVSVLR--QNQVEFEGLKHEI----------KRLEEETEYLNSQLED---A 229
E + V +L + +++ +G++++ + L E + L++Q+
Sbjct: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3099
Query: 230 IRLKEISERQLEEALE-TLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGL---KF 285
++ ++ SE+ +E LE ++ ++ Q ++ ELS S+ D +S + + +
Sbjct: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELS---SMKDRATELQEQLSSEKMVVAEL 3156
Query: 286 SDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEI 345
+ A+ + E + +H L +L K + + LL++ SE
Sbjct: 3157 KSELAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEV---------HLLNDTLASEQ 3206
Query: 346 QKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE 405
+K ++ +E+EKA L + + +++LE + SL Q+++ +L NL ++ Q E
Sbjct: 3207 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL--NLLLEQQKQLLNE 3264
Query: 406 RQTALDNEK----DRDSHEDGDYYEVDI--NGPEILACKYHVAVAEAGELREQLKALRST 459
Q +++++ + S E G E+ + ++ + + EL QL++ T
Sbjct: 3265 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3324
Query: 460 HEAREAQHAEE-----KGRYEAEGQALTEKVSLLEKASRQDRELLARLEKE 505
++R +E+ + + E + + E ++ EK + ++EK+
Sbjct: 3325 GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375
Score = 34.7 bits (78), Expect = 0.37
Identities = 45/215 (20%), Positives = 92/215 (42%), Gaps = 46/215 (21%)
Query: 51 LEEKH----QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQE 106
LEEKH +L + E+ ++D R +ME+ ++ + ++ +G+ + L
Sbjct: 3344 LEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQS- 3402
Query: 107 SASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD 166
KV +LQ +L++ R + E +RL + QE Q E++R R+
Sbjct: 3403 ----------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF----QKQELEREEKRES 3448
Query: 167 IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFE-----------------GLK 209
L Q+ +E +++ + + + Q ++E E G
Sbjct: 3449 -------RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCN 3501
Query: 210 HEIKRLEEETEYLNSQLEDAIRLKEISER-QLEEA 243
HE++ + ++ + + S+L+ + ++ SER Q E A
Sbjct: 3502 HELEMIRQKLQCVASKLQ--VLPQKASERLQFETA 3534
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 80.1 bits (196), Expect = 8e-15
Identities = 175/822 (21%), Positives = 327/822 (39%), Gaps = 102/822 (12%)
Query: 22 LRAEVKRLSHELAETTREKIQAAE-YGLAVLEEKHQLKLQFEE---LEVDYEAIRSEMEQ 77
L+ +V +L+ +L + QA E V E+K L+ + LE + S++ +
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 78 LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQS 137
KE Q K ++ E L+ A+K + +LQ L +N L + Q
Sbjct: 633 SKEKVSQLDIQIK-------AKTELLLSAEAAK----TAQRADLQNHLDTAQNALQDKQQ 681
Query: 138 ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
E ++ + ++ Q+ + +L +KEYK + Y LE++ L+ Q+
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK-------EKYLSLEQKTEELEGQIKK 734
Query: 198 LRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER------ 251
L + +E + K + + ++ LN+ LE +R E+S +QLE E + + R
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLE--LRATELS-KQLEMEKEIVSSTRLDLQKK 791
Query: 252 -----EQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHG 306
K L K+ + F T + E NN + V +
Sbjct: 792 SEALESIKQKLTKQEEEKQILKQDFETLSQETKI-------QHEELNNRIQTTVTELQKV 844
Query: 307 GLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE----KAGL 362
+ K L + ST K+ L+ S SL + SE E QK K ++ +E+ K L
Sbjct: 845 KMEKEALMTELST-VKDKLSKVSDSL-KNSKSEFE-KENQKGKAAILDLEKTCKELKHQL 901
Query: 363 LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
+++T K+ + + SL +++E +L L++++ Q + + T NEK+ + G
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE-QLIQAQNTLKQNEKE-EQQLQG 959
Query: 423 DYYEVDINGP------EILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEA 476
+ E+ + E L + +AV + EL +L+ + T A+E A EK
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ-QLTQAAQEL--AAEK----- 1011
Query: 477 EGQALTEKVSLLEKASRQDRELLARL-------EKELKKVSDVAGETQGSLSVAQDELVT 529
EK+S+L+ + +E +L E EL + LS+AQ++L++
Sbjct: 1012 ------EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 530 FSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKG 589
++ N + + + D ++ Q R E + ++ K
Sbjct: 1066 NRNQIGN-QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS 1124
Query: 590 LLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTT 649
LA E L S + +E N+ + ++ Q LQ D
Sbjct: 1125 KLA-EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 650 ELSRQRIASQE-LGPAVDKDKEALMEEILKLKSLLST--KREQITTLRTVLKANKQTAEV 706
Q +Q+ L V K++E L +E ++ ++ L + K +++ + K T ++
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243
Query: 707 A-----LANLKSKYENEKAMVTETMMK---LRNELKALKEDAATFSSLRAMFATRC---- 754
L +K ++++ + V+E + LR E+ L+ R RC
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
Query: 755 ---DEYITQLDEMQRQL---AAAEDEKKTLNSLLRMAIQQKL 790
++ T++ E+QR+L AA E N L++ Q L
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQAL 1345
Score = 77.8 bits (190), Expect = 4e-14
Identities = 167/847 (19%), Positives = 340/847 (40%), Gaps = 106/847 (12%)
Query: 6 EEEEYARLVM-EAQPEWL----RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQ 60
E E+Y L EA+P+ L AE++ L +L E E + ++ QL +
Sbjct: 112 ELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATE 171
Query: 61 FEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASK--EQYYVRKV 118
+++ Y+ RS L+EA Q T + ++E ++IQ+ ++ ++ + V
Sbjct: 172 IADIKSKYDEERS----LREAAEQKVTR----LTEELNKEATVIQDLKTELLQRPGIEDV 223
Query: 119 LELQTELKQLRNVLTN----TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFRE 174
L+ EL Q++ ++ N + E+E+L ++L+ + E +LR ++ +
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 283
Query: 175 ARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKE 234
A +Q+ +L+ L ++ L +N ++ E +++ E ++ + K+
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343
Query: 235 ISERQL-------EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSD 287
+ +QL E +L + E +K ++L +S ++ Y HL L+
Sbjct: 344 LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKY-QHLKAEFKQLQQQR 402
Query: 288 DAAEPNN-DAEALVN-------------GFEHGGL-AKLPLDNKTSTPKKEGLAPPSPSL 332
+ E + ++ +N G HG L + L ++ K++ +A L
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 333 --VSDLLSE--LNISEIQ----KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQ 384
+ + L E N +E+Q K KQQ + + + A L++ Q LE + ++
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD 522
Query: 385 EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVA 444
+K+ +NL AL LQ SKE + L+ E++ D + E + L K H
Sbjct: 523 QKI----QNLEAL--LQKSKENISLLEKERE-DLYAKIQAGEGETAVLNQLQEKNHTLQE 575
Query: 445 EAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEK 504
+ +L E+LK +H+ + ++ +A +A ++V LE + EL ++L +
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV---NELNSQLNE 632
Query: 505 ELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
+KVS + + + + + + A+L +H+ +T + D +E
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL-----DTAQNALQDKQQE----- 682
Query: 565 GRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREP 624
+ + + D S L S L + + +
Sbjct: 683 -----------------------LNKITTQLDQVTAKLQDKQ-EHCSQLESHLKEYKEKY 718
Query: 625 MNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLS 684
+++ + QIK L+A Q + + ++ D E E+ K L
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK---QLE 775
Query: 685 TKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKED----- 739
++E +++ R L+ + E ++ +K E EK ++ + L E K E+
Sbjct: 776 MEKEIVSSTRLDLQKKSEALE-SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834
Query: 740 AATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLE-- 797
T + L+ + + + +T+L ++ +L+ D K S Q+ A LE
Sbjct: 835 QTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 798 LLELDHE 804
EL H+
Sbjct: 894 CKELKHQ 900
Score = 73.2 bits (178), Expect = 9e-13
Identities = 162/855 (18%), Positives = 334/855 (39%), Gaps = 143/855 (16%)
Query: 8 EEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQ--------LKL 59
+E A V E Q L++ V L+ + +T E + E LEEKH ++
Sbjct: 281 QEVAVYVQELQK--LKSSVNELTQK-NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQA 337
Query: 60 QFEELEVDYEAIRSEM---------------------EQLKEAFGQAHTNHKKVAADGES 98
+ ++D + ++S + ++LKE + T ++ + A+ +
Sbjct: 338 TLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 397
Query: 99 REESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEI 158
L Q+ KEQ+ L+LQ+E+ QL + L T+ + L LKE Q
Sbjct: 398 ----LQQQREEKEQHG----LQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSE 446
Query: 159 QRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKH----EIKR 214
+ + + + + +RL + E + LQ Q+ +Q E + L+ +++
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 215 LEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTS 274
+ + E + Q+ D + + E L+++ E + +++ L ++ ++ +
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ--AGEGETAVLN 564
Query: 275 HLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL-- 332
L L+ + E L N E A+ L ++ K A L
Sbjct: 565 QLQEKNHTLQ-----EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 333 ---VSDLLSELNISEIQKLKQQLMQMEREKAGLL-------ATLQDTQKQLEHTRGSLSE 382
V++L S+LN S+ +K+ Q +Q++ + LL A D Q L+ + +L +
Sbjct: 620 ETSVNELNSQLNESK-EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 383 QQEKVTRLTENLSALR-RLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441
+Q+++ ++T L + +LQ +E + L++ +Y E KY
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK-------EYKE-----------KYLS 720
Query: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQA-----LTEKVSLLEKASRQDR 496
+ EL Q+K L + ++ E + ++E+ + + Q L + + L K ++
Sbjct: 721 LEQKTEELEGQIKKLEA--DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 497 ELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDY 556
E+++ +L+K S+ + L+ ++E ++ L + + E NR+
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQT-- 836
Query: 557 YREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP 616
T E + + + K L E S S +S
Sbjct: 837 ----------------TVTELQ----KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 617 LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEI 676
+ ++ I +L ++ LQ ++ T + +EL +++K+KEA +
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLK------EQKELKKSLEKEKEASHQ-- 928
Query: 677 LKLKSLLSTKREQITTLRTVLKANKQTAEVALAN---LKSKYENEKAMV----------- 722
LK L++ +EQ+ + LK N++ + N LK E +K +
Sbjct: 929 --LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV 986
Query: 723 ---TETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLN 779
TE KL+ +L ++ A ++ ++ ++Q E E
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1046
Query: 780 SLLRMAIQQKLALTQ 794
L+ ++++KL+L Q
Sbjct: 1047 QDLK-SVEEKLSLAQ 1060
Score = 65.9 bits (159), Expect = 2e-10
Identities = 118/597 (19%), Positives = 246/597 (41%), Gaps = 97/597 (16%)
Query: 7 EEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFE---- 62
+E+Y L +E + E L ++K+L + E K QA L L+++ QL E
Sbjct: 715 KEKY--LSLEQKTEELEGQIKKLEADSLEVKASKEQA----LQDLQQQRQLNTDLELRAT 768
Query: 63 ----ELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESRE------ESLIQESASKEQ 112
+LE++ E + S L++ + +K+ E ++ E+L QE+ + +
Sbjct: 769 ELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 113 YYVRKVLELQTELKQLR---------------------NVLTNTQSENER--------LA 143
++ TEL++++ + L N++SE E+ +
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL 888
Query: 144 SVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV----SVLR 199
+ + KE+ +++Q + KE K + + +L+ E S+Q+Q+ + L+
Sbjct: 889 DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLK 948
Query: 200 QNQVEFEGLK---HEIKRLEE----ETEYLNSQLEDAI----RLKEISERQLEEALETLK 248
QN+ E + L+ +E+K+ E + E L +L+ A+ L+ ++QL +A + L
Sbjct: 949 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 249 TEREQ----KNSLRKELSHYMSINDSFY--TSHLHVSLDGLKFSDDAAEPNNDAEALVNG 302
E+E+ +N+ K + + FY S L + LK ++ + + + N
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE-DLISNR 1067
Query: 303 FEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
+ G KL + KT+ +L D S ++Q+ + L +++EK+
Sbjct: 1068 NQIGNQNKLIQELKTA----------KATLEQD--SAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 363 LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKE-------RQTALDNEKD 415
L + + +L Q++++T+L E L + +L++ KE +Q + + +
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS-HKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 416 RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTH------EAREAQHAE 469
D V+ K V E +E ++ H E +H E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 470 EKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE 526
+ + + AL E + ++K + + ++ LEK+ + + ++ QDE
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
Score = 51.2 bits (121), Expect = 4e-06
Identities = 134/721 (18%), Positives = 269/721 (37%), Gaps = 120/721 (16%)
Query: 121 LQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQD 180
L+ E++ L+ L + +E L ++ + + Q G + D E + E +L
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL--- 144
Query: 181 YSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL 240
E + EN ++++ + Q + L E + S+ ++ L+E +E+++
Sbjct: 145 -EEAQTENFNIKQMKDLFEQKAAQ----------LATEIADIKSKYDEERSLREAAEQKV 193
Query: 241 EEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALV 300
E L E L+ EL I D V + L + E ++E L
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL-MDNMTLERERESEKL- 251
Query: 301 NGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELN---------ISEIQKLKQQ 351
K K + S + +S L SEL + E+QKLK
Sbjct: 252 ---------------KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 352 LMQMEREKAGLLATL----QD-TQKQLEHTRGSLSEQ-------------QEKVTRLTEN 393
+ ++ ++ L L QD T+ + +H S+S++ Q+ +RL+ +
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356
Query: 394 LSALRRLQAS-KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQ 452
++L R+ E+ A K+ S + Y + + L + +L+ +
Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ-LQQQREEKEQHGLQLQSE 415
Query: 453 LKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV 512
+ L S E Q E GR + + Q +EK+ E+ + L+RLE++LK+
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 513 AGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGR 572
+ E Q L + + +E L E N + + G
Sbjct: 476 STELQHQLDKTKQQ----HQEQQALQQSTTAKLREAQNDLEQVLRQIG------------ 519
Query: 573 TSPEARGRRSPILLPK-----GLLAPEA----GRADGGTGDSSPSPGSSLPSPLSDPRRE 623
+ + + LL K LL E + G G++ + L+ + +
Sbjct: 520 -DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET---------AVLNQLQEK 569
Query: 624 PMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALME-EILKLKSL 682
+ + + +++K+ + + E ++ Q+ +D+ +E + +L S
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 683 LSTKREQITTLRTVLKANKQ---TAEVALANLKSKYENEKAMVTETMMKLRNELKALKED 739
L+ +E+++ L +KA + +AE A ++ +N + + EL
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL------ 683
Query: 740 AATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELL 799
++ TQLD++ +L ++ L S L+ ++ L+L Q+ E L
Sbjct: 684 ---------------NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 800 E 800
E
Sbjct: 729 E 729
Score = 37.7 bits (86), Expect = 0.044
Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 665 VDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTE 724
V +KEALM E+ +K LS + + ++ + Q + A+ +L+ + K +
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 725 TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTL----NS 780
M E K LK+ + QL + Q L E E++ L N
Sbjct: 904 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE 963
Query: 781 LLRMAIQQ-----------KLALTQRLEL-LELDHEQTRRGRAKAAPKTK 818
L + + Q+ K+A+ Q+ EL +L + T+ + AA K K
Sbjct: 964 LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Score = 34.7 bits (78), Expect = 0.37
Identities = 28/160 (17%), Positives = 73/160 (45%), Gaps = 2/160 (1%)
Query: 1 MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKH-QLKL 59
+ A E+E+ + +++ Q + E+K+ E +I+ E G+ EE +L +
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241
Query: 60 QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVL 119
Q L + ++ E + + + + + + E+ +Q + + + + + L
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGE-IAVLEATVQNNQDERRALLERCL 1300
Query: 120 ELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQ 159
+ + E+++L+ + Q + + + QEL NQ+++I+
Sbjct: 1301 KGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/133 (18%), Positives = 58/133 (43%), Gaps = 10/133 (7%)
Query: 631 IAIIRDQIKHLQAAVDR----TTELSR-----QRIASQELGP-AVDKDKEALMEEILKLK 680
+ ++R +++ LQA++ + EL + Q + QE P + D A ++ + +
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 681 SLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDA 740
T+ I ++ + + +A++KSKY+ E+++ K+ + L ++A
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 741 ATFSSLRAMFATR 753
L+ R
Sbjct: 205 TVIQDLKTELLQR 217
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 79.7 bits (195), Expect = 1e-14
Identities = 115/507 (22%), Positives = 213/507 (42%), Gaps = 46/507 (9%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
E L K+L+ L E E ++A + LE+ KH+L+ + E+L VD E +
Sbjct: 1384 EELEEAKKKLAQRLQEA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA-- 1440
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNV----LTN 134
A + N K+ A+ + + E ES S+ + ++ L TEL +L+N L +
Sbjct: 1441 --ALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 135 TQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQ 194
++ ++ +E+ ++ + + + + K K EA ++ S LEE SL+ +
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 195 VSVLRQNQVEFEGLKHEIKR-LEEETEYLNSQLEDAIRLKEISERQLE-------EALET 246
+ + Q+EF +K EI+R L E+ E + + +R+ + + L+ EAL
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 247 LKTEREQKNSLRKELSH--YMSINDSFYTSHLHVSLDGLKFS-DDAAEPNNDAEALVNGF 303
K N + +LSH M+ L L + DDA N+D + +
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 304 E-HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
E L + L+ + ++ S L L E + +Q L Q + +K +
Sbjct: 1675 ERRNNLLQAELEELRAVVEQ---TERSRKLAEQELIETS-ERVQLLHSQNTSLINQKKKM 1730
Query: 363 LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
A L Q ++E +EK + + +A+ + KE+ T+ E+ + + E
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQ- 1788
Query: 423 DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
I ++ + AE L+ K L+ EA+ E + EAE +
Sbjct: 1789 ----------TIKDLQHRLDEAEQIALKGGKKQLQKL----EARVRELENELEAEQKRNA 1834
Query: 483 EKVSLLEKASRQDRELLARLEKELKKV 509
E V + K+ R+ +EL + E++ K +
Sbjct: 1835 ESVKGMRKSERRIKELTYQTEEDRKNL 1861
Score = 79.3 bits (194), Expect = 1e-14
Identities = 179/891 (20%), Positives = 344/891 (38%), Gaps = 139/891 (15%)
Query: 22 LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEA 81
++ E RL L ++ + + E +++L+EK+ L+LQ + + + +QL +
Sbjct: 852 MKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKN 911
Query: 82 FGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENER 141
Q K++ E EE + E +K++ + EL+ ++ L L + E
Sbjct: 912 KIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHA 970
Query: 142 LASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQN 201
+ + L E ++ +L + K + + L D E++ +L K L Q
Sbjct: 971 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ 1030
Query: 202 QVEFEG---------------------------------------LKHEIKRLEEETEYL 222
+ EG L +K+ + E L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 223 NSQLED--------AIRLKEISER--QLEEALETLKTEREQKNSLRKELSHYMSINDSFY 272
N+++ED +LKE+ R +LEE LE +T R + LR +LS
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR--------- 1141
Query: 273 TSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSL 332
L+ + + A + +N K+ D + +T + E A
Sbjct: 1142 ------ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 333 VSDLLSEL--NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
+D ++EL I +Q++KQ+L E+EK+ L D +E EK+ R
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKL---EKEKSEFKLELDDVTSNMEQII-KAKANLEKMCRT 1251
Query: 391 TENLSALRRLQASKERQTA--LDNEKDRDSHEDGDYYEVDINGPEILACK-------YHV 441
E+ R +A + +++ L +++ + E+G+ ++ E L + Y
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR-QLDEKEALISQLTRGKLTYTQ 1310
Query: 442 AVAE-AGELREQLKALRS-THEAREAQHAEE--KGRYEAEGQALTEKVSLLEKASRQDRE 497
+ + +L E++KA + H + A+H + + +YE E +A E +L KA+ + +
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
Query: 498 LLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR------ 551
+ E + + ++ E + L+ E +EE + C +T +R
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKKLAQRLQE----AEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 552 -VMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPG 610
+M+D R A + + + R +L + E +++ +SS
Sbjct: 1427 DLMVDVERSNAAAA---------ALDKKQRNFDKILAEWKQKYEESQSE---LESSQKEA 1474
Query: 611 SSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKE 670
SL + L + + + + K+LQ + ++L+ Q +S + ++K ++
Sbjct: 1475 RSLSTELFKLKNAYEESLEHLETFKRENKNLQ---EEISDLTEQLGSSGKTIHELEKVRK 1531
Query: 671 ALMEEILKLKSLL-----STKREQITTLRTVLKANKQTAEV--ALANLKSKYENEKAMVT 723
L E ++L+S L S + E+ LR L+ N+ AE+ LA + E K
Sbjct: 1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL 1591
Query: 724 ETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLR 783
+ L+ L A ++ +E QL R A A+ + K+L SLL+
Sbjct: 1592 RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651
Query: 784 MA-------------IQQKLALTQR--------LELLELDHEQTRRGRAKA 813
+++ +A+ +R LE L EQT R R A
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1702
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/250 (20%), Positives = 112/250 (44%), Gaps = 13/250 (5%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
+++A+ E LRA V++ +E I+ +E + + L Q ++++ D +++
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 74 EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
E+E+ + A KK D E L +E + + R ++ +K L++ L
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLD 1798
Query: 134 NTQS-----ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
+ ++L + ++E+ +E ++ R + +K + E R+ + + EE+
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDR 1858
Query: 189 ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
+L + ++ + Q++ + K ++ EE E N+ L ++ + +L+EA E
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYK---RQAEEAEEQANTNLSKFRKV----QHELDEAEERAD 1911
Query: 249 TEREQKNSLR 258
Q N LR
Sbjct: 1912 IAESQVNKLR 1921
Score = 47.4 bits (111), Expect = 6e-05
Identities = 56/256 (21%), Positives = 119/256 (46%), Gaps = 35/256 (13%)
Query: 12 RLVMEAQPEW--LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYE 69
R+ EAQ + L++ +K +L + R E +A++E ++ L L+ + E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNL------LQAELE 1686
Query: 70 AIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLR 129
+R+ +EQ + + +K+A E+ LI E++ + Q + L + K++
Sbjct: 1687 ELRAVVEQTERS--------RKLA------EQELI-ETSERVQLLHSQNTSLINQKKKMD 1731
Query: 130 NVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENI 189
L+ Q+E E + +E + + +++K+ + A L + +E+
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791
Query: 190 SLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE-------DAIRLKEISERQLEE 242
LQ ++ Q+ +G K ++++LE L ++LE ++++ SER+++E
Sbjct: 1792 DLQHRLD--EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Query: 243 ALETLKTEREQKNSLR 258
T +TE ++KN LR
Sbjct: 1850 L--TYQTEEDRKNLLR 1863
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 79.7 bits (195), Expect = 1e-14
Identities = 168/812 (20%), Positives = 332/812 (40%), Gaps = 85/812 (10%)
Query: 45 EYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLI 104
+ L++L+E L+ E+LEV + E+ LKE FG H+K E +
Sbjct: 532 DMSLSLLQEISSLQ---EKLEVTRTDHQREITSLKEHFGAREETHQK-----EIKALYTA 583
Query: 105 QESASKEQYYVRKVLELQTELKQLRNVLTNTQSENE-RLASVAQELKEINQNVEIQRGRL 163
E SKE ++ LE K+ +V+ +S+ E +AS Q ++E+ + G
Sbjct: 584 TEKLSKENESLKSKLEHAN--KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 641
Query: 164 RDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHE----IKRLEEET 219
+ E K + ++ DY E EN+ Q Q S + E E L+ + IK E
Sbjct: 642 TAEFAELKTQIEKMRLDYQH-EIENLQNQ-QDSERAAHAKEMEALRAKLMKVIKEKENSL 699
Query: 220 EYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLH-- 277
E + S+L+ A + L+ + + ++ L+ + + + D+F TS L
Sbjct: 700 EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF-TSQLKAT 758
Query: 278 ----VSLDGLKFSDDAAEP-----NNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPP 328
+ LD L+ + + EA +H + K +K S+ +E
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE---LQ 815
Query: 329 SPSLVSDLLSELNISEIQKLKQQL---MQMEREK-AGLLATLQDTQKQLEHTRGSLSEQQ 384
L L E N+SE+ ++K+ L +Q+ +EK A Q+ ++ T L +++
Sbjct: 816 GRELKLTNLQE-NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 874
Query: 385 EKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDI---------NGPEIL 435
E+ L+ +L LR A E + +E++ + + E DI N ++
Sbjct: 875 EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 934
Query: 436 ACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQD 495
+ + E QLK ++ A Q + E +AE Q+ E E+ ++
Sbjct: 935 KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE-QSQQEAAKKHEEEKKEL 993
Query: 496 RELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLD 555
L+ LEK+++ + E + A E T EE+ + + +LD
Sbjct: 994 ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL-----------QNLQKTLLD 1042
Query: 556 YYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPS 615
+ +G S + E R + K A A A + +L S
Sbjct: 1043 TEDKLKGAREENSGLLQELEELRKQAD-----KAKAAQTAEDAMQIMEQMTKEKTETLAS 1097
Query: 616 PLSDPRREPMNIYNLIAIIRD-QIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALME 674
L D ++ + N + +++ +K+++ EL++ S+EL ++ E +
Sbjct: 1098 -LEDTKQTNAKLQNELDTLKENNLKNVE-------ELNK----SKELLTVENQKMEEFRK 1145
Query: 675 EILKLKSLLSTKREQITTLR--TVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNE 732
EI LK + K +Q++ L+ V A + K E E++++ +++++
Sbjct: 1146 EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR 1205
Query: 733 ----LKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEK---KTLNSLLRMA 785
+K E+ A+ ++ + E +L++++ ++ E K+L+S+++
Sbjct: 1206 ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTL 1265
Query: 786 IQQKLALTQRLELLELDHEQTRRGRAKAAPKT 817
K+ L +++ LEL ++ +R + ++ T
Sbjct: 1266 ESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297
Score = 76.3 bits (186), Expect = 1e-13
Identities = 158/821 (19%), Positives = 335/821 (40%), Gaps = 110/821 (13%)
Query: 69 EAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQL 128
EA++ + + +++ + +VA S + QE A + + VLEL+ ++ QL
Sbjct: 355 EALKEKQQHIEQLLAERDLERAEVAK-ATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 129 RNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
R ++ E L + +L+E + VE + R+ ++ E + +++ ++E
Sbjct: 414 RTMVEAADREKVELLN---QLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
Query: 189 ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISE----------- 237
SL + + + Q E E + + + E++ + + + A+R++E++E
Sbjct: 471 QSLLFEKTKADKLQRELEDTR--VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPA 528
Query: 238 -------------RQLEEALETLKTEREQK-NSLR-----KELSHYMSINDSFYTSHLHV 278
L+E LE +T+ +++ SL+ +E +H I + YT+ +
Sbjct: 529 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK-ALYTATEKL 587
Query: 279 SLDGLKFS---DDAAEPNNDAEALVNGFEHGGLA---KLPLDNKTSTPKKEGLAPPSPSL 332
S + + A + N+D AL +A + + K S K G +
Sbjct: 588 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 647
Query: 333 VSDLLSELNIS---EIQKLKQQ--------LMQMEREKAGLLATLQDTQKQLEHTRGSLS 381
+ + ++ + EI+ L+ Q +ME +A L+ +++ + LE R L
Sbjct: 648 LKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707
Query: 382 EQQEKVTRLTENLSALRRLQAS--KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKY 439
+ +++ L E L +LQ + K ++ + K + + D + + E
Sbjct: 708 KAEDQ--HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 765
Query: 440 HVAVAEAGELREQLKALRSTHEAREAQ--HAE-EKGRYEAEGQALTEKVSLLEKASRQDR 496
+ E + ++K LR EA E Q H E EK ++ ++T ++ Q R
Sbjct: 766 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL--------QGR 817
Query: 497 EL-LARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNN------ETP 549
EL L L++ L +VS V + L + +++ SEE ++ + N E
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 877
Query: 550 NRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSP 609
N + D + + A + E R ++ K L + +GD+S S
Sbjct: 878 NMLSSDLEKLRENLADMEA----KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNS-SQ 932
Query: 610 GSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDK 669
+ + L R+ + + + LQ +++ T + Q + QE +++K
Sbjct: 933 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEK 990
Query: 670 EALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKL 729
+ L ++ L+ + T Q L K E A + K+K+E + +T++
Sbjct: 991 KELERKLSDLEKKMETSHNQCQEL-------KARYERATSETKTKHEEILQNLQKTLLDT 1043
Query: 730 RNELKALKEDAATF---------SSLRAMFATRCDEYITQLDEMQRQ----LAAAEDEKK 776
++LK +E+ + + +A A ++ + +++M ++ LA+ ED K+
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1103
Query: 777 T-------LNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
T L++L ++ L + ELL +++++ R
Sbjct: 1104 TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1144
Score = 67.0 bits (162), Expect = 7e-11
Identities = 106/546 (19%), Positives = 207/546 (37%), Gaps = 57/546 (10%)
Query: 7 EEEYARLVMEAQPEWLRAEVKRLSHELA---ETTREKIQAAEYGLAVLEEKHQLKLQFEE 63
+++ R + E LRA++ ++ E E R K+ AE V E KLQ E
Sbjct: 669 QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE 728
Query: 64 LEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQT 123
++V E+E L QA N + D + + +E + E ++
Sbjct: 729 IKV------KELEVL-----QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 777
Query: 124 ELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGR-LRDDIKEYKFREARLLQDYS 182
E+K+LR L + + + L EI +N E + + +++ + + L ++ S
Sbjct: 778 EMKKLRQQLEAAEKQIKHL--------EIEKNAESSKASSITRELQGRELKLTNLQENLS 829
Query: 183 ELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEE 242
E+ + +L+K++ +L++ E ++R +ET Q E+ + +L E
Sbjct: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 243 ALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDG----LKFSDDAAEPNNDAEA 298
L ++ + +K+ ++L ++ + +S D K +D+ D E
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE 949
Query: 299 LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMERE 358
L KL N+ + S + + ++ + Q ++ + E E
Sbjct: 950 L--------QLKLTKANENA------------SFLQKSIEDMTVKAEQSQQEAAKKHEEE 989
Query: 359 KAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNE---KD 415
K L L D +K++E + E + + R T ++T LD E K
Sbjct: 990 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1049
Query: 416 RDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYE 475
G E++ + K +A ++ EQ+ ++ A + + +
Sbjct: 1050 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109
Query: 476 AEGQALTEKVSLLEKASRQDRELLA-------RLEKELKKVSDVAGETQGSLSVAQDELV 528
E L E + + +ELL KE++ + A + LS Q+E V
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169
Query: 529 TFSEEL 534
+EEL
Sbjct: 1170 KLAEEL 1175
Score = 61.6 bits (148), Expect = 3e-09
Identities = 101/495 (20%), Positives = 195/495 (39%), Gaps = 53/495 (10%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLK 79
E L E++ L + AE + E + + + HQ + QF L D E +R + ++
Sbjct: 836 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME 895
Query: 80 EAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSEN 139
F + + REE LI+ E + QL + + +
Sbjct: 896 AKF-----------REKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 944
Query: 140 ERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSEL-EEENISLQKQVSVL 198
+ + +L + N+N L+ I++ + + Q+ ++ EEE L++++S L
Sbjct: 945 RDVEELQLKLTKANENASF----LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000
Query: 199 RQNQVEFEGLKHEIK-RLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSL 257
+ E+K R E T ++ E+ + + ++ L + + LK RE+ + L
Sbjct: 1001 EKKMETSHNQCQELKARYERATSETKTKHEEIL---QNLQKTLLDTEDKLKGAREENSGL 1057
Query: 258 RKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT 317
+EL D + D ++ + + + A E L N+
Sbjct: 1058 LQELEELRKQADK--AKAAQTAEDAMQIMEQMTKEKTETLA---SLEDTKQTNAKLQNEL 1112
Query: 318 STPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTR 377
T K+ L N+ E+ K K +L+ +E +K +T KQ +
Sbjct: 1113 DTLKENNLK--------------NVEELNKSK-ELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 378 G-SLSEQQEKVTRLTENLSALR----RLQASKERQTALDNE----KDRDSH--EDGDYYE 426
LS QE+ +L E L R Q +E ++ L+N+ K R+S +D D +
Sbjct: 1158 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1217
Query: 427 VDI-NGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKV 485
+ I + AE +LR ++ LR + + ++ H+ + E++ L KV
Sbjct: 1218 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ-TLESDKVKLELKV 1276
Query: 486 SLLEKASRQDRELLA 500
LE ++++ L+
Sbjct: 1277 KNLELQLKENKRQLS 1291
Score = 43.5 bits (101), Expect = 8e-04
Identities = 40/207 (19%), Positives = 97/207 (46%), Gaps = 9/207 (4%)
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIA--SQELGPAVDKDKEALMEEILK 678
++E +Y + + + L++ ++ + + IA +L A+ ++A+ E +
Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
Query: 679 LKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNEL-KALK 737
L T+ + L+T ++ + + + NL+++ ++E+A + M LR +L K +K
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
Query: 738 EDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLAL---TQ 794
E + ++R+ D+++ ++++ +L AE + K L L +Q + T
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 795 RLELLE---LDHEQTRRGRAKAAPKTK 818
+L+ E LD + R+ ++ + K
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMK 780
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 19/135 (14%)
Query: 379 SLSEQQEKVTRLTENLSAL-RRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILAC 437
S+S + + LTE S R++ + Q AL K++ H + E D+ E+
Sbjct: 325 SVSSRPSRTGLLTETSSRYARKISGTTALQEAL---KEKQQHIEQLLAERDLERAEVAKA 381
Query: 438 KYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRE 497
HV GE+ ++L R H+ QH E EA+ L +++E A R+ E
Sbjct: 382 TSHV-----GEIEQELALARDGHD----QHVLE---LEAKMDQLR---TMVEAADREKVE 426
Query: 498 LLARLEKELKKVSDV 512
LL +LE+E +KV D+
Sbjct: 427 LLNQLEEEKRKVEDL 441
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 79.3 bits (194), Expect = 1e-14
Identities = 159/818 (19%), Positives = 318/818 (38%), Gaps = 142/818 (17%)
Query: 22 LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEE----LEVDYEAIRSEMEQ 77
L E K ++ E ++ QA E LE+ ++K E+ LE + + +E++
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 78 LKEAFGQAHTNHKKVAA----------DGES-REE----------------SLIQESASK 110
L + G + KKV A +GE R E L+ +S SK
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 111 EQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEY 170
+ L+++L+ + +L Q EN + S++ +LK+ VE ++ R+ ++E
Sbjct: 1296 SSKLTKDFSALESQLQDTQELL---QEENRQKLSLSTKLKQ----VEDEKNSFREQLEEE 1348
Query: 171 KFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEG---LKHEIKR-LEEETEYLNSQL 226
+ EA+ LE++ +L QV+ +++ + G E+KR L+++ E L+ +
Sbjct: 1349 E--EAK-----HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 227 EDAI-------RLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVS 279
E+ + + K +++L++ L L +R+ +L K+ + + T +
Sbjct: 1402 EEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYA 1461
Query: 280 LDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSE 339
+ + +A E A +L E K L+ + E + DL+S
Sbjct: 1462 EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE---------MEDLMSS 1512
Query: 340 LNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR 399
+ + + + ++E+ K L +++ + QLE L ++ RL NL A++
Sbjct: 1513 KD-----DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK- 1566
Query: 400 LQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRST 459
A ER +E+ + + L + AE + R+Q +
Sbjct: 1567 --AQFERDLQGRDEQSEEKKKQ-------------LVRQVREMEAELEDERKQRSMAVAA 1611
Query: 460 HEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDV---AGET 516
+ E + + ++ + E + L K Q ++ + L+ ++ A E
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Query: 517 QGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPE 576
+ L + E++ EELA R +
Sbjct: 1672 EKKLKSMEAEMIQLQEELA---------------------------------AAERAKRQ 1698
Query: 577 ARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRD 636
A+ R LA E + G G + L + ++ E +I D
Sbjct: 1699 AQQERDE-------LADEIANS-SGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
Query: 637 QIKHLQAAVDR-TTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRT 695
++K +D+ T+L+ +R +Q K++ A + + K L +E T+++
Sbjct: 1751 RLKKANLQIDQINTDLNLERSHAQ-------KNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 696 VLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLR---AMFAT 752
KA+ E +A L+ + +NE ++R K LK+ R +
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 753 RCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
+ D+ T+L +++RQL AE+E + N+ R +Q++L
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANA-SRRKLQREL 1900
Score = 74.7 bits (182), Expect = 3e-13
Identities = 128/559 (22%), Positives = 228/559 (40%), Gaps = 101/559 (18%)
Query: 9 EYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAE--YGLAVLEEKHQLKL------- 59
E ++++E Q L E K L +AE T + E LA L+ KH+ +
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERL 1036
Query: 60 -----QFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL------IQESA 108
Q +ELE + + L + + ++ +EE L ++E A
Sbjct: 1037 RREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096
Query: 109 SKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRD--- 165
+++ ++K+ EL++++ +L+ L +SE ++ +++ + +E + L D
Sbjct: 1097 AQKNMALKKIRELESQISELQEDL---ESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153
Query: 166 ------DIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEET 219
+++ + +E +L+ LEEE + + Q+ +RQ KH +
Sbjct: 1154 STAAQQELRSKREQEVNILK--KTLEEEAKTHEAQIQEMRQ--------KH-----SQAV 1198
Query: 220 EYLNSQLEDAIRLKEISERQLEEALETLKTER-EQKNSLRKELSHYMSINDSFYTSHLHV 278
E L QLE R+K LE+A +TL+ ER E N ++ L +
Sbjct: 1199 EELAEQLEQTKRVK----ANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254
Query: 279 SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKT-----STPKKEGLAPPSPSLV 333
+KF++ A+ + ++ LDN T S K L +L
Sbjct: 1255 QELQVKFNEGERVRTELADKVTK-------LQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 334 S------DLLSELN---ISEIQKLKQ----------QLMQ-------MEREKAGLLATLQ 367
S +LL E N +S KLKQ QL + +E++ A L A +
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 368 DTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDN-EKDRDS-HEDGDYY 425
D +K++E + G L +E +L ++L L Q +E+ A D EK + ++ D
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLS--QRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 426 EVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKV 485
VD++ AC + +L + K + A++AEE+ R EAE + K
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTI-------SAKYAEERDRAEAEAREKETKA 1478
Query: 486 SLLEKASRQDRELLARLEK 504
L +A + E A LE+
Sbjct: 1479 LSLARALEEAMEQKAELER 1497
Score = 70.1 bits (170), Expect = 8e-12
Identities = 161/859 (18%), Positives = 335/859 (38%), Gaps = 131/859 (15%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKH-QLKLQFEELEVDYEAIRSEMEQL 78
+W R K E++ A E L + EK + + E+E + +E QL
Sbjct: 826 QWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQL 885
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
+E QA T ++ A+ E L +K+Q +L+ +++ + Q+E
Sbjct: 886 QEQL-QAET---ELCAEAEELRARL----TAKKQELEEICHDLEARVEEEEERCQHLQAE 937
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVL 198
+++ QEL+E + E R +L+ + + + +L ++ LE++N L K+ +L
Sbjct: 938 KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 199 RQNQVEF-------EGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTER 251
EF E + +L+ + E + + LE+ +R +E ++LE+ L+ +
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 252 EQKNSLRKEL-SHYMSINDSFYTSHLHVSLDGLKFSDDAAEPN------NDAEALVNGFE 304
+ EL + + + + ++AA+ N + E+ ++ +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 305 HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLL- 363
++ NK K++ L +L ++L L+ + Q Q+L ++ +L
Sbjct: 1118 EDLESERASRNKAEKQKRD-LGEELEALKTELEDTLDSTAAQ---QELRSKREQEVNILK 1173
Query: 364 ATLQDTQKQLEHTRGSLSEQQEK----VTRLTENLSALRRLQASKER-QTALDNEKDRDS 418
TL++ K E + E ++K V L E L +R++A+ E+ + L+NE+ +
Sbjct: 1174 KTLEEEAKTHE---AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230
Query: 419 HE---------DGDYYEVDINGP-EILACKYHVAVAEAGELREQLKALRSTHEAREAQHA 468
+E D ++ + + L K++ EL +++ L+ + +
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 469 EEKGRYEAEGQALTEKVSLLEKASRQDRELLAR-------LEKELKKVSDVAGETQGSLS 521
+ +++ LT+ S LE + +ELL L +LK+V D + L
Sbjct: 1291 QS----DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 522 VAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRR 581
++ +++A L+ V D ++ + G T+ E + +
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVA------------DMKKKMEDSVGCL----ETAEEVKRK- 1389
Query: 582 SPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHL 641
L K L LS E + Y+ + + +++
Sbjct: 1390 ----LQKDL------------------------EGLSQRHEEKVAAYDKLEKTKTRLQ-- 1419
Query: 642 QAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANK 701
Q D +L QR ++ L + K+ +++L + +S K + K
Sbjct: 1420 QELDDLLVDLDHQRQSACNL-----EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 702 QTAEVALANLKSKYENEKAMVTETMMKLRNELKAL---KEDAA----TFSSLRAMFATRC 754
+T ++LA + +KA + + R E++ L K+D + +
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534
Query: 755 DEYITQLDEMQRQLAAAEDEKKTLNSLLR---------------MAIQQKLALTQRLELL 799
+E TQL+E++ +L A ED K L L+ + ++K L +++ +
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594
Query: 800 ELDHEQTRRGRAKAAPKTK 818
E + E R+ R+ A K
Sbjct: 1595 EAELEDERKQRSMAVAARK 1613
Score = 66.2 bits (160), Expect = 1e-10
Identities = 116/546 (21%), Positives = 214/546 (39%), Gaps = 86/546 (15%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSH---------ELAETTREKIQAAEYGLAVLEE--- 53
EEEE A+ +E Q L A+V + E AE + K+Q GL+ E
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405
Query: 54 ---------KHQLKLQFEELEVDYEAIRSE---MEQLKEAFGQAHTNHKKVAA---DGES 98
K +L+ + ++L VD + R +E+ ++ F Q K ++A +
Sbjct: 1406 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465
Query: 99 REESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEI 158
R E+ +E +K R + E + +L + ++E E L S ++ + +E
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Query: 159 QRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEE 218
+ L ++E K + L + E+ + L+ + ++ +FE +++ +E+
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK---AQFE---RDLQGRDEQ 1579
Query: 219 TEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHV 278
+E QL +R ++E LE + +R + RK+L +
Sbjct: 1580 SEEKKKQLVRQVR-------EMEAELEDERKQRSMAVAARKKLE---------------M 1617
Query: 279 SLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNK--------TSTPKKEGLAPPSP 330
L L+ D+A N D EA+ L KL K T ++E LA
Sbjct: 1618 DLKDLEAHIDSANKNRD-EAIKQ------LRKLQAQMKDCMRELDDTRASREEILAQAKE 1670
Query: 331 SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
+ L + IQ L+++L ER K + ++ ++ G + E+ RL
Sbjct: 1671 N--EKKLKSMEAEMIQ-LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 391 TENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELR 450
++ L ++ T L N++ + ++ D D+N A K A +
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 451 EQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLE-------KASRQDRELLARLE 503
++LK + K +Y+A AL K++ LE K + + + R E
Sbjct: 1788 KELKV------KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 504 KELKKV 509
K+LK V
Sbjct: 1842 KKLKDV 1847
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/254 (19%), Positives = 115/254 (45%), Gaps = 24/254 (9%)
Query: 22 LRAEVKRLSHELAETTREKIQAAEY--------------GLAVLEEKHQLKLQFEELEVD 67
+ AE+ +L ELA R K QA + G LEEK +L+ + +LE +
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737
Query: 68 YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQ 127
E + E + + +A+ ++ D + E S Q++ + Q R+ EL+ +L++
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTD-LNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 128 LRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEE 187
+ + + + + ++ ++ ++ + ++ + + K+ + E +L ++++E
Sbjct: 1797 MEGTVKSKYKAS--ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 188 NISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETL 247
+ ++ + + LK +++ EEE + N+ + +R+LE+A ET
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANAS-------RRKLQRELEDATETA 1907
Query: 248 KTEREQKNSLRKEL 261
+ +SL+ +L
Sbjct: 1908 DAMNREVSSLKNKL 1921
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 78.2 bits (191), Expect = 3e-14
Identities = 175/882 (19%), Positives = 341/882 (38%), Gaps = 109/882 (12%)
Query: 16 EAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEM 75
E + ++ E R+ L ++ + + E +++L+EK+ L+LQ + + +
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 76 EQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNT 135
+QL + Q K++ E EE + E +K++ + EL+ ++ L L
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLED-EEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKV 966
Query: 136 QSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQV 195
+ E + + L E ++ +L + K + + L D E++ SL K
Sbjct: 967 EKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSK 1026
Query: 196 SVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEIS-------ERQLEEALETLK 248
L Q + EG + K++ + E +LE ++L + S + QLEE L+ +
Sbjct: 1027 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKE 1086
Query: 249 TEREQKNS-----------LRKELSHYMSINDSF----------------YTSHLHVSLD 281
+ Q+NS L+K+L + + S L L+
Sbjct: 1087 FDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE 1146
Query: 282 GLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSEL- 340
+ + A + +N K+ D + +T + E A +D ++EL
Sbjct: 1147 EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1206
Query: 341 -NISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR 399
I +Q++KQ+L E+EK+ L D +E EKV+R E+ + R
Sbjct: 1207 EQIDNLQRVKQKL---EKEKSEFKLELDDVTSNMEQII-KAKANLEKVSRTLEDQANEYR 1262
Query: 400 LQASKERQTALD--NEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALR 457
++ + +++ D ++ + E+G+ +++ ++ ++ + + L
Sbjct: 1263 VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE 1322
Query: 458 STHEAREA-QHAEEKGR---------YEAEGQALTEKVSLLEKASRQDRELLARLEKELK 507
+A+ A HA + R YE E +A E +L KA+ + + + E +
Sbjct: 1323 EEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1382
Query: 508 KVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNR-------VMLDYYREG 560
+ ++ E + L+ + + +EE + C +T +R +M+D R
Sbjct: 1383 QRTEELEEAKKKLA----QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438
Query: 561 QGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDP 620
A + + + R +L + E +++ +SS SL + L
Sbjct: 1439 AAAA---------ALDKKQRNFDKILAEWKQKYEESQSE---LESSQKEARSLSTELFKL 1486
Query: 621 RREPMNIYNLIAIIRDQIKHLQAAV-DRTTELSRQRIASQELGPAVDKDKEALMEEILKL 679
+ + + + K+LQ + D T +L EL +K ++ L E L+L
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL----EKVRKQLEVEKLEL 1542
Query: 680 KSLL-----STKREQITTLRTVLKANKQTAEV--ALANLKSKYENEKAMVTETMMKLRNE 732
+S L S + E+ LR L+ N+ AE+ LA + E K + L+
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 733 LKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMA------- 785
L A ++ +E QL R A A+ + K+L SLL+
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 786 ------IQQKLALTQR--------LELLELDHEQTRRGRAKA 813
+++ +A+ +R LE L EQT R R A
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1704
Score = 75.5 bits (184), Expect = 2e-13
Identities = 116/507 (22%), Positives = 210/507 (41%), Gaps = 46/507 (9%)
Query: 20 EWLRAEVKRLSHELAETTREKIQAAEYGLAVLEE-KHQLKLQFEELEVDYEAIRSEMEQL 78
E L K+L+ L + E ++A + LE+ KH+L+ + E+L VD E +
Sbjct: 1386 EELEEAKKKLAQRLQDA-EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA-- 1442
Query: 79 KEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE 138
A + N K+ A+ + + E ES S+ + ++ L TEL +L+N +
Sbjct: 1443 --ALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 139 NERLASVAQELKEINQNVEIQRGRLRDDIKEY----KFREARLLQDYSELEEENISLQKQ 194
E + L+E ++ Q G ++ E K E L+ S LEE SL+ +
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556
Query: 195 VSVLRQNQVEFEGLKHEIKR-LEEETEYL------NSQLEDAIRLK-EISERQLEEALET 246
+ + Q+EF +K EI+R L E+ E + + ++ D+++ + R E L
Sbjct: 1557 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRV 1616
Query: 247 LKTEREQKNSLRKELSH--YMSINDSFYTSHLHVSLDGLKFS-DDAAEPNNDAEALVNGF 303
K N + +LSH M+ L L + DDA N+D + +
Sbjct: 1617 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676
Query: 304 E-HGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGL 362
E L + L+ + ++ S L L E + +Q L Q + +K +
Sbjct: 1677 ERRNNLLQAELEELRAVVEQ---TERSRKLAEQELIETS-ERVQLLHSQNTSLINQKKKM 1732
Query: 363 LATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDG 422
+ L Q ++E +EK + + +A+ + KE+ T+ E+ + + E
Sbjct: 1733 ESDLTQLQSEVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQ- 1790
Query: 423 DYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALT 482
I ++ + AE L+ K L+ EA+ E +G EAE +
Sbjct: 1791 ----------TIKDLQHRLDEAEQIALKGGKKQLQKL----EARVRELEGELEAEQKRNA 1836
Query: 483 EKVSLLEKASRQDRELLARLEKELKKV 509
E V + K+ R+ +EL + E++ K +
Sbjct: 1837 ESVKGMRKSERRIKELTYQTEEDKKNL 1863
Score = 73.2 bits (178), Expect = 9e-13
Identities = 166/850 (19%), Positives = 339/850 (39%), Gaps = 85/850 (10%)
Query: 22 LRAEVKRLSHELAETTREKIQAAEYGLAVLE-EKHQLKLQFEELEVDY---EAIRSEMEQ 77
L A+ ++L E +E ++ I E LA +E EKH + + + L + + I +++ +
Sbjct: 938 LTAKKRKLEDECSELKKD-IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996
Query: 78 LKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQS 137
K+A +AH A D EE + + + ++V +L+ L+Q + V + +
Sbjct: 997 EKKALQEAHQQ----ALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052
Query: 138 ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSV 197
+L + +E ++E + +L + +K+ +F + Q S++E+E + +
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD---INQQNSKIEDEQVLALQLQKK 1109
Query: 198 LRQNQVEFEGLKHEI---KRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQK 254
L++NQ E L+ E+ + + E L S L + L+EISER LEEA + E
Sbjct: 1110 LKENQARIEELEEELEAERTARAKVEKLRSDL--SRELEEISER-LEEAGGATSVQIEMN 1166
Query: 255 NSLRKELSHY-MSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFE----HGGLA 309
E + ++ + K +D AE + L +
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1226
Query: 310 KLPLDNKTSTPK-----KEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLA 364
KL LD+ TS + K L S +L D +E + ++++ ++ L ++A L
Sbjct: 1227 KLELDDVTSNMEQIIKAKANLEKVSRTL-EDQANEYRV-KLEEAQRSLNDFTTQRAKLQT 1284
Query: 365 TLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRR-LQASKERQTALDNEKDRDSHEDG- 422
+ +QLE +S+ T+ + L+R L+ + + AL + H+
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344
Query: 423 --DYYEVDINGPEILACKYHVAVAEAGELREQLK--ALRSTHEAREAQHAEEKGRYEAEG 478
+ YE + L A +E + R + + A++ T E EA+ + +AE
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1404
Query: 479 --QALTEKVSLLEKAS--------------RQDRELLARLEKELKKVSDVAGETQGSLSV 522
+A+ K S LEK + A L+K+ + + E +
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464
Query: 523 AQDELVTFSEELANLYHHVCMCNN---------ETPNRVMLDYYREGQGGAGRTSPGGRT 573
+Q EL + +E +L + N ET R + E + GG+
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524
Query: 574 SPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAI 633
E R + + K L A+ +SL R + + A
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAE-----------ASLEHEEGKILRAQLEFNQIKAE 1573
Query: 634 IRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTL 693
I ++ +++ + + QR+ L ++D + + E+L++K + ++
Sbjct: 1574 IERKLAEKDEEMEQ-AKRNHQRVV-DSLQTSLDAETRS-RNEVLRVKKKMEGDLNEMEI- 1629
Query: 694 RTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKA---LKEDAATFSSLRAMF 750
+ AN+ AE + + ++ ++++ +T ++L + ++A LKE+ A +
Sbjct: 1630 -QLSHANRMAAEA-----QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683
Query: 751 ATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGR 810
+E +++ +R AE E + +++ Q +L + + +E D Q +
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743
Query: 811 AKAAPKTKPA 820
+A + + A
Sbjct: 1744 EEAVQECRNA 1753
Score = 62.4 bits (150), Expect = 2e-09
Identities = 165/876 (18%), Positives = 329/876 (37%), Gaps = 123/876 (14%)
Query: 6 EEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAE----------YGLAVLEEKH 55
E+E+ R+ +E L ++K + + +K+Q E + +E++
Sbjct: 1041 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQ 1100
Query: 56 QLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESL---IQESASKEQ 112
L LQ ++ + +A E+E+ EA A +K+ +D E + ++E+
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Query: 113 YYVRKVLELQTELKQLRNVLTNTQSENERLA---------SVAQ------ELKEINQNVE 157
+ + + E +++R L ++E A SVA+ L+ + Q +E
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 158 IQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEE 217
++ + ++ + ++++ + LE+ + +L+ Q + R E + ++
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280
Query: 218 ETEYLNSQLEDAIRLKEISERQL-------EEALETLKTEREQKNSLRKELSHYMSINDS 270
+ + N +L + KE QL + +E LK + E++ + L+H +
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ---- 1336
Query: 271 FYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSP 330
+D + L +E AK L S E
Sbjct: 1337 --------------------SARHDCDLLREQYEEETEAKAELQRVLSKANSE------- 1369
Query: 331 SLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRL 390
V+ ++ IQ+ + ++E K L LQD ++ +E S ++ RL
Sbjct: 1370 --VAQWRTKYETDAIQRTE----ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRL 1423
Query: 391 TENLSALR-RLQASKERQTALDNEK---DRDSHEDGDYYEVDINGPEILACKYHVAVAEA 446
+ L ++ S ALD ++ D+ E YE + + EA
Sbjct: 1424 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-------QSELESSQKEA 1476
Query: 447 GELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKEL 506
L +L L++ +E +H E ++ E + L E++S L + + + + LEK
Sbjct: 1477 RSLSTELFKLKNAYE-ESLEHLE---TFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 507 KKVSDVAGETQGSLSVAQDELVTFSEEL--ANLYHHVCMCNNETPNRVMLDYYREGQGGA 564
K++ E Q +L A+ L ++ A L + E + + +
Sbjct: 1533 KQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592
Query: 565 GRTSPGGRTSPEARGR-RSPILLPKGLLAPEAGRAD------GGTGDSSPSPGSSLPSPL 617
R +TS +A R R+ +L K + + + + SL S L
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1652
Query: 618 SDPR-------REPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKE 670
D + R ++ IAI+ + LQA ++ + Q S++L +++
Sbjct: 1653 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL---AEQELI 1709
Query: 671 ALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLR 730
E + L S ++ Q + + L + E A+ ++ E K +T+ M +
Sbjct: 1710 ETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAM-MA 1768
Query: 731 NELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKL 790
ELK ++ +A ++ + +LDE ++ A + KK L QKL
Sbjct: 1769 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGGKKQL---------QKL 1817
Query: 791 ALTQRLELLELDHEQTR-----RGRAKAAPKTKPAT 821
R EL+ EQ R +G K+ + K T
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRIKELT 1853
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/250 (20%), Positives = 112/250 (44%), Gaps = 13/250 (5%)
Query: 14 VMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRS 73
+++A+ E LRA V++ +E I+ +E + + L Q +++E D ++S
Sbjct: 1682 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741
Query: 74 EMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLT 133
E+E+ + A KK D E L +E + + R ++ +K L++ L
Sbjct: 1742 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLD 1800
Query: 134 NTQS-----ENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEEN 188
+ ++L + ++E+ +E ++ R + +K + E R+ + + EE+
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDK 1860
Query: 189 ISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLK 248
+L + ++ + Q++ + K + + EE+ N+ L ++ + +L+EA E
Sbjct: 1861 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA---NTNLSKFRKV----QHELDEAEERAD 1913
Query: 249 TEREQKNSLR 258
Q N LR
Sbjct: 1914 IAESQVNKLR 1923
Score = 51.6 bits (122), Expect = 3e-06
Identities = 58/256 (22%), Positives = 119/256 (46%), Gaps = 35/256 (13%)
Query: 12 RLVMEAQPEW--LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYE 69
R+ EAQ + L++ +K +L + R E +A++E ++ L L+ + E
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNL------LQAELE 1688
Query: 70 AIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLR 129
+R+ +EQ + + +K+A E+ LI E++ + Q + L + K++
Sbjct: 1689 ELRAVVEQTERS--------RKLA------EQELI-ETSERVQLLHSQNTSLINQKKKME 1733
Query: 130 NVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENI 189
+ LT QSE E + +E + + +++K+ + A L + +E+
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793
Query: 190 SLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLE-------DAIRLKEISERQLEE 242
LQ ++ Q+ +G K ++++LE L +LE ++++ SER+++E
Sbjct: 1794 DLQHRLD--EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Query: 243 ALETLKTEREQKNSLR 258
T +TE ++KN LR
Sbjct: 1852 L--TYQTEEDKKNLLR 1865
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 77.8 bits (190), Expect = 4e-14
Identities = 150/752 (19%), Positives = 302/752 (40%), Gaps = 100/752 (13%)
Query: 119 LELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQR--GRLRDDIKEYKFREAR 176
L++ ++ QL V+ ++N+ S Q LK+ ++ EIQ+ R+ I +YK +
Sbjct: 42 LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE-EIQQILAETREKILQYKSKVTE 100
Query: 177 LLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE---------------EETEY 221
L +++ SL+ + + +Q EFE KH ++ ++ E E
Sbjct: 101 ELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEE 160
Query: 222 LNSQLEDAIR----LKEISERQLEEALETLKT--EREQKNSLRKELSHYMSINDSFYTSH 275
+ + E+ +R L+ E+ ALE L+ RE + L+ + H S+N +
Sbjct: 161 IRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAE 220
Query: 276 LHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLP--LDNKTSTPKKEGL-----APP 328
++ + E + + L+ +E G L K + + T K+ L
Sbjct: 221 ELHRMEVESLNKMLEELRLERKKLIEDYE-GKLNKAQSFYERELDTLKRSQLFTAESLQA 279
Query: 329 SPSLVSDLLSELNISE------IQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSE 382
S +DL E E I KLK +L ++ E LL Q Q L ++
Sbjct: 280 SKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQV 339
Query: 383 QQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVA 442
Q+++ E AL L KE ++ L ++R + D ++ H+
Sbjct: 340 LQKQLDDAKEGEMAL--LSKHKEVESELAAARERLQQQASD----------LVLKASHIG 387
Query: 443 VAEAGELREQ-----LKALRSTHEAREAQHAEEKGRYEAEGQALTEK-----VSLLEKAS 492
+ +A ++ ++ L++ +S R +Q EE+ ++ Q+L E+ + L +K +
Sbjct: 388 MLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVN 447
Query: 493 RQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHV--CMCNNETPN 550
R E+ELK + E L+ A + + EELA +H + +N +
Sbjct: 448 EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL---EELAWKHHMAIEAVHSNAIRD 504
Query: 551 RVMLDYYREGQGGAGRTS---PGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSP 607
+ L E Q + + + E + + E G S
Sbjct: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
Query: 608 SPGSS--LPSPLSDPRREPMNIYNLIAIIRDQIKHLQ-AAVDRTTELSRQRIASQELGPA 664
GS+ L + L D + + N + + +D +K + A ++ EL ++R +E A
Sbjct: 565 GLGSAEGLIASLQDSQER---LQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAA 621
Query: 665 VDKDKEALMEEILKLKSLLSTK--REQITTLRTVLKANKQTAEVALANLKSKYENEKAMV 722
+ ++++ ++++ + T+ R++ + LR L+ ++E +K
Sbjct: 622 MKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE--------------ELRLQHEEDKKSA 667
Query: 723 TETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKT-LNSL 781
+++L++ K D+ + + ++ + Q+ +++ L + +T L L
Sbjct: 668 MSQLLQLKDREKNAARDS---------WQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQL 718
Query: 782 LRMAIQQKLALTQRLELLELDHEQTRRGRAKA 813
Q++ LTQ LE LE H+Q + +A
Sbjct: 719 QAQFTQERQRLTQELEELEEQHQQRHKSLKEA 750
Score = 59.3 bits (142), Expect = 1e-08
Identities = 118/580 (20%), Positives = 247/580 (42%), Gaps = 105/580 (18%)
Query: 5 SEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAV-------LEEKHQL 57
+++E Y R + Q L EV +L+ ++T E A ++ +A+ + +K +L
Sbjct: 452 TQQEYYERELKNLQSR-LEEEVTQLNEAHSKTLEEL--AWKHHMAIEAVHSNAIRDKKKL 508
Query: 58 KLQFEE--------LEVDYEAIRSEMEQLKEAF-GQAHTNHKKV---------AADGESR 99
++ EE LE D ++ E+E LKE + +T ++++ + G
Sbjct: 509 QMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGS 568
Query: 100 EESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSE--------NERLASVAQELK- 150
E LI ++ ++ + LK+ ++ L N + E E +A++ +E K
Sbjct: 569 AEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKL 628
Query: 151 -----------EINQNVEIQRGRLRDDIK---------------EYKFREARLLQDYSEL 184
+ +N+ + +LR++++ + K RE +D +
Sbjct: 629 KVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 688
Query: 185 EEENISLQKQVSVLRQN-QVEFEGLKHEIKRLE----EETEYLNSQLEDAIRLKEISERQ 239
+ E+ L Q+S+L+QN +++ + +++L+ +E + L +LE+ + +
Sbjct: 689 KVED--LLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 746
Query: 240 LEEA-LETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEA 298
L+EA + +T E+K ++ L +++ S + L D + S + + E
Sbjct: 747 LKEAHVLAFQTMEEEKEKEQRALENHLQQKHS---AELQSLKDAHRESMEGFRIEMEQEL 803
Query: 299 LVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQM--- 355
FE K L + S + A DLL + E+ K +L +
Sbjct: 804 QTLRFELEDEGKAMLASLRSELNHQHAA------AIDLLRHNHHQELAAAKMELERSIDI 857
Query: 356 -EREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALR-----------RLQAS 403
R+ + + D Q++L H +SE ++V L EN+SAL R+++
Sbjct: 858 SRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSE 917
Query: 404 KERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLK----ALRST 459
+Q L +E+D + + E+D+ + L K ++ A+ + E LK AL+ +
Sbjct: 918 SNQQIRL-HEQDLNKRLE---KELDVMTADHLREK-NIMRADFNKTNELLKEINAALQVS 972
Query: 460 HEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELL 499
E E ++ + + E + Q +TE ++L + + ++L+
Sbjct: 973 LEEMEEKYLMRESKPE-DIQMITELKAMLTERDQIIKKLI 1011
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,632,354
Number of Sequences: 37866
Number of extensions: 1368483
Number of successful extensions: 17171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 316
Number of HSP's successfully gapped in prelim test: 1053
Number of HSP's that attempted gapping in prelim test: 8153
Number of HSP's gapped (non-prelim): 5693
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.