Search of human proteins with 217272874

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|217272874 coiled-coil domain containing 37 [Homo sapiens]
         (611 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|217272874 coiled-coil domain containing 37 [Homo sapiens]         1202   0.0  
gi|226491199 coiled-coil domain containing 38 [Homo sapiens]          272   6e-73
gi|148746195 trichohyalin [Homo sapiens]                               62   1e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    60   4e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    60   6e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        57   4e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        57   4e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         57   4e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         57   4e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         57   4e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         57   4e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         57   4e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         57   4e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       57   4e-08
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    57   5e-08
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   57   5e-08
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    57   6e-08
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    57   6e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    56   1e-07
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    55   1e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    55   2e-07
gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo sa...    55   2e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    54   3e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       54   3e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     53   7e-07
gi|71061468 centromere protein E [Homo sapiens]                        53   7e-07
gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo sa...    53   9e-07
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]             53   9e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    52   1e-06
gi|110815815 centlein isoform 1 [Homo sapiens]                         51   3e-06

>gi|217272874 coiled-coil domain containing 37 [Homo sapiens]
          Length = 611

 Score = 1202 bits (3111), Expect = 0.0
 Identities = 611/611 (100%), Positives = 611/611 (100%)

Query: 1   MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDV 60
           MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDV
Sbjct: 1   MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDV 60

Query: 61  DFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAE 120
           DFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAE
Sbjct: 61  DFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAE 120

Query: 121 AEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLAT 180
           AEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLAT
Sbjct: 121 AEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLAT 180

Query: 181 KEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV 240
           KEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV
Sbjct: 181 KEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV 240

Query: 241 NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNST 300
           NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNST
Sbjct: 241 NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNST 300

Query: 301 PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
           PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR
Sbjct: 301 PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360

Query: 361 GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
           GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH
Sbjct: 361 GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420

Query: 421 TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
           TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES
Sbjct: 421 TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480

Query: 481 LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
           LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER
Sbjct: 481 LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540

Query: 541 RIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMD 600
           RIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMD
Sbjct: 541 RIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMD 600

Query: 601 KEEEELLFFFT 611
           KEEEELLFFFT
Sbjct: 601 KEEEELLFFFT 611


>gi|226491199 coiled-coil domain containing 38 [Homo sapiens]
          Length = 563

 Score =  272 bits (696), Expect = 6e-73
 Identities = 183/559 (32%), Positives = 296/559 (52%), Gaps = 35/559 (6%)

Query: 61  DFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAE 120
           D FL+++ E     +E+   + M+V+QK T+SS++  K  S   QL    K+        
Sbjct: 32  DLFLVKENEMAAKETEKFMNRNMKVYQKTTFSSRM--KSHSYLSQLAFYPKRSG------ 83

Query: 121 AEHQRAFRDYTTWKLTLTK--EKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETL 178
               R+F  +      + +  E +     +  +I  +R  FLL+YAL  KR  I++ E  
Sbjct: 84  ----RSFEKFGPGPAPIPRLIEGSDTKRTVHEFINDQRDRFLLEYALSTKRNTIKKFEKD 139

Query: 179 ATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQ 238
               E +L++AEK L+ DA  F+EF+REND  SV A++ A +ET  K++   E++  + +
Sbjct: 140 IAMRERQLKKAEKKLQDDALAFEEFLRENDQRSVDALKMAAQETINKLQMTAELKKASME 199

Query: 239 IVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVN 298
           +  +KSEI++ E  L+ Y  Y  FL ++SPK W  +Q  K +   K+K      K  +  
Sbjct: 200 VQAVKSEIAKTEFLLREYMKYGFFLLQMSPKHWQIQQALKRAQASKSKANIILPKILAKL 259

Query: 299 STPGDKGPGI---KGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESS 355
           S       GI    G+ + +     QG     +   +  L R+P          +  +S+
Sbjct: 260 SLHSSNKEGILEESGRTAVLSEDASQGRDSQGK--PSRSLTRTP----------EKKKSN 307

Query: 356 GGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTL 415
             +S GS   +    +D      EP LYF EP++LL V RELEEQNL+L Q SQ+ ++ L
Sbjct: 308 LAESFGSEDSLEFLLDDEMDVDLEPALYFKEPEELLQVLRELEEQNLTLFQYSQDVDENL 367

Query: 416 EELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQD 475
           EE++   K  Q + +  +  L +    +  +  +EE+ AAEL+LK+++F FGE+  D Q+
Sbjct: 368 EEVNKREKVIQDKTNSNIEFLLEQEKMLKANCVREEEKAAELQLKSKLFSFGEFNSDAQE 427

Query: 476 KLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERA 535
            L++SL+ K+  VY+ C G  ++  L  +Q L  +E +L EL + +E +P+  +E  ER 
Sbjct: 428 ILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKENVEAIERM 487

Query: 536 KEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQ-- 593
           K+KE R + R+EK++ ++  Q+E L+ A  +A A+ KKK GR LV  S+PP+   KQQ  
Sbjct: 488 KQKEWRQKFRDEKMKEKQRHQQERLKAALEKAVAQPKKKLGRRLVFHSKPPSGN-KQQLP 546

Query: 594 -SEHTLMDKEEEELLFFFT 611
               T    +EEE  +FFT
Sbjct: 547 LVNETKTKSQEEE--YFFT 563


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 124/566 (21%), Positives = 230/566 (40%), Gaps = 68/566 (12%)

Query: 64  LLRDQERNKA-----LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEAR 118
           L RDQE  +      L E ++++     ++     +   +   L+RQ + E  Q+ L  R
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL--R 533

Query: 119 AEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETL 178
           +E + +R   +     L   +EK +E E     +K++++    Q    +KR E +R + L
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL---LKREEERRQQRL 590

Query: 179 ATKEEARLERAEK-----SLEKDAALFDEFVRE--NDCSSVQAMRAAEKETKAKIEKILE 231
             ++E RLE+  K      LE++        RE   +    Q +++ E+E + + +   E
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 232 IRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAK---EV 288
            ++   Q +  + E  R E  LK     +    +L+ +E  + +E+  S + K +   E 
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710

Query: 289 SEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
              +++S V S P  K  G + +      +  + ++  W+  +     +           
Sbjct: 711 EADARQSKVYSRP-RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769

Query: 349 SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
              +E      R   S  PP +E       E QL   E QQ    F   EE+     +  
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQ-----RERQLRAEERQQREQRFLPEEEEKEQRRRQR 824

Query: 409 QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGE 468
           +E EK L+ L    +  Q++      QL++           EED   E + + R     E
Sbjct: 825 REREKELQFLE---EEEQLQRRERAQQLQE-----------EEDGLQEDQERRR---SQE 867

Query: 469 YKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQL---DELLENLEHVP 525
            + DQ+              +R     +++    T+     ++ QL    +LL+  E   
Sbjct: 868 QRRDQK--------------WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913

Query: 526 QVKIEQAERAKEKERRIRLREEKLQM--QKILQEEHLQRARARAQAEI---KKKRGRTLV 580
           Q +  +  R +E+ER+ R  EE+LQ   +++L+EE  +R R   + +    KK + +   
Sbjct: 914 QREEREKRRRQEQERQYR-EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972

Query: 581 CRSRPPAHRIKQQSEHTLMDKEEEEL 606
                P  R +Q+ E     +EEEEL
Sbjct: 973 LLGEEPEKRRRQEREKKY--REEEEL 996



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 113/571 (19%), Positives = 225/571 (39%), Gaps = 61/571 (10%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEH 123
            L R+QE  +    ++Q++  R+ Q++    ++  +    R QL   ++++ LE   E   
Sbjct: 507  LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ--ERRE 564

Query: 124  QRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEE 183
            QR  R+    +  L K    E E     +K++++  L Q    +KR E++RLE    +E+
Sbjct: 565  QRLKREQEERRDQLLKR---EEERRQQRLKREQEERLEQR---LKREEVERLEQEERREQ 618

Query: 184  ARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIK 243
             RL+R E   E+   L      E +    Q +R  ++E + +  K  E  +   Q +  +
Sbjct: 619  -RLKREEPEEERRQQLLKS--EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675

Query: 244  SEISRFEDTL--KHYKVYKDFLYKLSPK-EWLEEQEKKHSFLKKAKEVSEASKESSVNST 300
             E  R E  L  +  +  ++ +    PK +W  E E      +++K  S   K+      
Sbjct: 676  HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD---ARQSKVYSRPRKQEGQRRR 732

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKP------------WRFLQTMRLGRSPSYLSSPQQG 348
               +    + ++   W +E +  ++             W+  +    GR       P + 
Sbjct: 733  QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGE-----EPQLYFTEPQQLL---DVFRELEEQ 400
             +  +    + +       P +E+ +         E +L F E ++ L   +  ++L+E+
Sbjct: 793  QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852

Query: 401  NLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMS-ITKEEDTAAELEL 459
               L Q  QE  ++ E+        Q+  +R+  +   +    +   + KE+    E E 
Sbjct: 853  EDGL-QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911

Query: 460  KARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLE 519
            + +     + +  +Q++            YR     QQE      Q+L     +      
Sbjct: 912  ELQREEREKRRRQEQERQ-----------YREEEQLQQEEE----QLLREEREKRRRQER 956

Query: 520  NLEHVPQVKIEQAER---AKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRG 576
              ++    K++Q E     +E E+R R   EK    K  +EE LQ+   +   E ++KR 
Sbjct: 957  ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK----KYREEEELQQEEEQLLREEREKRR 1012

Query: 577  RTLVCRSRPPAHRIKQQSEHTLMDKEEEELL 607
            R    R       ++Q+ E  L ++ E+  L
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRL 1043



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 116/564 (20%), Positives = 214/564 (37%), Gaps = 114/564 (20%)

Query: 32  EENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTY 91
           EE P++Q    EE                    LR  ER +   ERQ+++  +  Q++  
Sbjct: 262 EEEPQRQRELQEEEEQ-----------------LRKLERQELRRERQEEEQQQ--QRLRR 302

Query: 92  SSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGY 151
             ++  K    RR+ Q E+++E  E R + E +R        +L   +E+  E +     
Sbjct: 303 EQQLRRKQEEERRE-QQEERREQQERREQQEERR------EQQLRREQEERREQQLRREQ 355

Query: 152 IKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSS 211
            +++R+   L+   + +RRE Q       + E +L R E+ L ++     +  RE     
Sbjct: 356 EEERREQ-QLRREQEEERREQQLRREQQLRREQQLRR-EQQLRRE----QQLRREQQLRR 409

Query: 212 VQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEW 271
            Q +R   +E + + E+ L  R+   +    K E  R E  LK                 
Sbjct: 410 EQQLR---REQQLRREQQLR-REQEEERHEQKHEQERREQRLK----------------- 448

Query: 272 LEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQ 331
             EQE++  +LK+ +E     +E        D+    + +    W K  +  ++  +  +
Sbjct: 449 -REQEERRDWLKREEETERHEQERRKQQLKRDQ----EEERRERWLKLEEEERREQQERR 503

Query: 332 TMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL 391
             +L R        +   Q  E                        E  Q      QQL 
Sbjct: 504 EQQLRREQEERREQRLKRQEEE------------------------ERLQQRLRSEQQLR 539

Query: 392 DVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEE 451
              RE EE+   L++  +E     E     LK  Q   +R    LK+        + +E+
Sbjct: 540 ---REQEERREQLLKREEEKRLEQERREQRLKREQ--EERRDQLLKREEERRQQRLKREQ 594

Query: 452 DTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIE 511
           +   E  LK       E +  ++ +L                  ++E      Q L   E
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRL-----------------KREEPEEERRQQLLKSE 637

Query: 512 HQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEI 571
            Q +   +      Q++ EQ ER   +E+R++  EE+ ++++ L+ EH +  R +  AE 
Sbjct: 638 EQEERRQQ------QLRREQQER---REQRLKREEEEERLEQRLKREHEEERREQELAEE 688

Query: 572 KKKRGRTLVCRSRPPAHRIKQQSE 595
           ++++ R  + +SR P  + + +SE
Sbjct: 689 EQEQARERI-KSRIPKWQWQLESE 711



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 113/555 (20%), Positives = 218/555 (39%), Gaps = 112/555 (20%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAF 127
            QE  + L E Q+++  R  ++  Y  +   +    +++ + ED++ DL+ + E E + A 
Sbjct: 1178 QEEEQLLREEQEKR--RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235

Query: 128  RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYAL--------DVKRREIQRLETLA 179
            RD   +      E+  + E+     +Q +Q   LQ+ L        + +RR  Q+ +   
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQD--LQHLLGEQQERDREQERRRWQQRDRHF 1293

Query: 180  TKEEARLERAE----KSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDL 235
             +EE +LER E    K  ++ +    + +RE      +  R  E + K + E+ L +++ 
Sbjct: 1294 PEEE-QLEREEQKEAKRRDRKSQEEKQLLRE---EREEKRRRQETDRKFREEEQL-LQER 1348

Query: 236  TTQIVNIKSEISRF-EDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKE 294
              Q +  +    +F E+ L+H +  + F   L  ++ L  QE++  FLK+ +++    +E
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKF---LEEEQRLRRQERERKFLKEEQQLRCQERE 1405

Query: 295  SSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSES 354
              +     D+    + +   + +++ +  K      Q  R  R   +L   QQ  Q    
Sbjct: 1406 QQLRQ---DRDRKFREEEQQL-SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ---- 1457

Query: 355  SGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKT 414
                                    E    F E +QLL   +E EEQ L      +   K 
Sbjct: 1458 ------------------------ERHRKFREEEQLL---QEREEQQL---HRQERDRKF 1487

Query: 415  LEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQ 474
            LEE     +  + R  RE              +  +E     LE + ++     ++  +Q
Sbjct: 1488 LEEEQQLRRQERDRKFRE------------QELRSQEPERKFLEEEQQL-----HRQQRQ 1530

Query: 475  DKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAER 534
             K L                 Q+E  L   +         D      E + Q + EQ   
Sbjct: 1531 RKFL-----------------QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573

Query: 535  AKEKERRIRLREEKLQMQ---KILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIK 591
             +E++R+ RL E+K++ Q   +   E+  Q  R   Q +++++R R              
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF------------ 1621

Query: 592  QQSEHTLMDKEEEEL 606
            ++ E  L ++EE++L
Sbjct: 1622 REDEQLLQEREEQQL 1636



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 107/556 (19%), Positives = 232/556 (41%), Gaps = 73/556 (13%)

Query: 66  RDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQR 125
           ++QER  A  E Q +K  R+ Q+         +   L RQ Q  + QE  E RAE E  +
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDR-----QRRDEELWRQRQ--EWQEREERRAEEEQLQ 194

Query: 126 AFRDYTTWKLT----LTKEKNVEPENMSGYIKQK----RQMFLLQYALDVKRREIQRLET 177
           + + + T +      L + + +E        KQ+    RQ  + Q   + + +E ++ ET
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQ---EEEEKEWRKRET 251

Query: 178 LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
           +  KEE +L+  E   +++    +E +R+ +   ++  R  E++ + ++ +  ++R    
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR--- 308

Query: 238 QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSV 297
                K E  R E   +          +   +E  E+QE++    ++ +   E  +E  +
Sbjct: 309 -----KQEEERREQQEE----------RREQQERREQQEERRE--QQLRREQEERREQQL 351

Query: 298 NSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGG 357
                ++    + +      +  Q  ++  +  +  +L R    L   QQ  +  +    
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQL-RREQQLRREQQLRREQQLRRE 410

Query: 358 DSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEE 417
                   +   Q+      EE      E ++     +  +E+    ++  +ETE+  +E
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470

Query: 418 LSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKL 477
                +  Q++ D+E  + ++W+        +EE+   + E + +     + + +Q+++ 
Sbjct: 471 ----RRKQQLKRDQEEERRERWLK------LEEEERREQQERREQ-----QLRREQEERR 515

Query: 478 LESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELL---ENLEHVPQVKIEQAER 534
            + L        R     + +  L + Q L   + +  E L   E  + + Q + EQ  +
Sbjct: 516 EQRLK-------RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568

Query: 535 AKEKERRIRL--REEKLQMQKIL--QEEHLQRARARAQAE-IKKKRGRTLVCRSRPPAHR 589
            +++ERR +L  REE+ + Q++   QEE L++   R + E ++++  R    +   P   
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628

Query: 590 IKQQSEHTLMDKEEEE 605
            +QQ    L+  EE+E
Sbjct: 629 RRQQ----LLKSEEQE 640



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 102/547 (18%), Positives = 209/547 (38%), Gaps = 70/547 (12%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSS---KVSAKHTSLRRQLQLEDKQEDLEARAEA 121
            LR QER + L + + +K     Q+++      K   +   +RRQ + E K  + E +   
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ-ERERKFLEEEQQLRQ 1457

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E  R FR+         +E+ ++        +Q+R    L+    ++R+E  R      +
Sbjct: 1458 ERHRKFRE---------EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK---FRE 1505

Query: 182  EEARLERAE-KSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV 240
            +E R +  E K LE++  L  +  +       Q +R  E+  + + ++  + R+      
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE------ 1559

Query: 241  NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNST 300
              + ++ +  +  +  +  +D  ++L  ++ +  QE++  F++  +++     +  +   
Sbjct: 1560 --EEQLRQEREEQQLSRQERDRKFRLEEQK-VRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSS-PQQGSQPSESSGGDS 359
               K    +     +  +E Q         Q  R  R   +L   PQ   Q  E      
Sbjct: 1617 RDRK---FREDEQLLQEREEQ---------QLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664

Query: 360  RGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELS 419
            R         +E    +GEE QL   E  +    FRE E+Q    ++  +   K L+E  
Sbjct: 1665 RDRKFR---EEEQLLQEGEEQQLRRQERDRK---FREEEQQ----LRRQERERKFLQEEQ 1714

Query: 420  HTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLE 479
               +    R  RE  QL+Q           E++     E   ++    + + +++++ L 
Sbjct: 1715 QLRRQELERKFREEEQLRQ---------ETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765

Query: 480  SLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKE 539
                      R     ++E      +   +   + D      E + Q + EQ  R ++++
Sbjct: 1766 RQE-------RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818

Query: 540  RRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLM 599
             + R  EE+LQ+     EE  QR R     + + +       +SR     + Q+ E    
Sbjct: 1819 GKYRWEEEQLQL-----EEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRR 1873

Query: 600  DKEEEEL 606
             + E +L
Sbjct: 1874 QERERKL 1880



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 112/545 (20%), Positives = 204/545 (37%), Gaps = 108/545 (19%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQED---LEARAEA 121
            +R QER +   E +QQ     H+K     ++  +    R + QL  ++ D   LE   + 
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQE----REEQQLHRQERDRKFLEEEQQL 1494

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRRE------IQRL 175
              Q   R +   +L   + +    E      +Q+RQ   LQ    ++R+E        R 
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554

Query: 176  ETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK-AKIEKILEIRD 234
                 +E+ R ER E+ L +     D   R  +    Q +R  E+E K  + E+ L  ++
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQER--DRKFRLEE----QKVRRQEQERKFMEDEQQLRRQE 1608

Query: 235  LTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLE----------EQEKKHSFLKK 284
               Q+   +    R ++ L   +  +    +   +++LE          EQ+ +H   +K
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668

Query: 285  AKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWR---FLQ---------T 332
             +E  +  +E       G++    + +    + +E Q  ++  R   FLQ          
Sbjct: 1669 FREEEQLLQE-------GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721

Query: 333  MRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLD 392
             R  R    L    +  Q               + P +E+     +E    F E +QL  
Sbjct: 1722 ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR- 1780

Query: 393  VFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEED 452
              +E EEQ L     SQE+++   E        Q+R +RE  QL+           +E+ 
Sbjct: 1781 --QEREEQQL----RSQESDRKFRE------EEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828

Query: 453  TAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEH 512
               E E + R     +Y+ ++Q                    TQ+++             
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQ------------------FATQEKS-----------RR 1859

Query: 513  QLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIK 572
            +  EL +          E+ +R +E+ER  +LREE ++ Q+  ++ H      R   EIK
Sbjct: 1860 EEQELWQE---------EEQKRRQERER--KLREEHIRRQQKEEQRH------RQVGEIK 1902

Query: 573  KKRGR 577
             + G+
Sbjct: 1903 SQEGK 1907



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 107/581 (18%), Positives = 231/581 (39%), Gaps = 75/581 (12%)

Query: 66   RDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQED----------- 114
            R Q+  +   ER++Q+  R  ++     ++  +H   RR+ +L +++++           
Sbjct: 643  RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702

Query: 115  -----LEARAEA------------EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQK-- 155
                 LE+ A+A            E QR  ++    +     E   + E  +   +Q+  
Sbjct: 703  KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762

Query: 156  -RQMFLLQYALDVK----RREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCS 210
             R+ F  Q+  + K    R+ +     L  + E +L   E+   +   L +E  +E    
Sbjct: 763  QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ--- 819

Query: 211  SVQAMRAAEKETK-AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPK 269
              +  R  EKE +  + E+ L+ R+   Q+   +  +   ++  +  +  +D  ++   +
Sbjct: 820  RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879

Query: 270  EWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRF 329
            E  E + ++H+   K     +  KE  +          ++ +   +  +E +  ++    
Sbjct: 880  E--ERKRRRHTLYAKPALQEQLRKEQQL----------LQEEEEELQREEREKRRRQ--- 924

Query: 330  LQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQ 389
             +  R  R    L   ++     E    + R         ++D     +E QL   EP++
Sbjct: 925  -EQERQYREEEQLQQEEEQLLREER---EKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980

Query: 390  LLDVFRELEEQNLSLIQNSQETEKTL-EELSHTLKHTQIRMDREVNQLKQWVTTMMMSIT 448
                 RE + +    +Q  QE E+ L EE     +    R  R+ ++L+Q    ++    
Sbjct: 981  RRRQEREKKYREEEELQ--QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL---- 1034

Query: 449  KEEDTAAELELKARVFHFGEYKGDQQDKLL----ESLNCKVLD-VYRHCTGTQQEANLGT 503
            +EE     L+ + R +   E    ++++LL    E+   + L+  YR     QQE     
Sbjct: 1035 REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEE--- 1091

Query: 504  VQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRA 563
             Q+L     +        +   + +++Q E    +E R + R ++L+ Q   +EE +Q+ 
Sbjct: 1092 -QLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ-YREEEEVQQE 1149

Query: 564  RARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
              +   E  +KR R  + R       ++Q+ E  L +++E+
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 100/558 (17%), Positives = 216/558 (38%), Gaps = 59/558 (10%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEH 123
            LLR++   K   +   +K     Q +    +   +     R+ + E+ +   + R   E 
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE 1379

Query: 124  QRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEE 183
            ++  R     +  L +E+ +  +     ++Q R     +    + R+E  R      ++ 
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439

Query: 184  ARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIK 243
             R ER  K LE++  L  E  R+         R  E+  + + E+ L  ++   + +  +
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRK--------FREEEQLLQEREEQQLHRQERDRKFLEEE 1491

Query: 244  SEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGD 303
             ++ R E   K  +  ++   +   +++LEE+++ H   ++ K + E  +          
Sbjct: 1492 QQLRRQERDRKFRE--QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL--------- 1540

Query: 304  KGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ--PSESSGGDSRG 361
                   +      +  Q   + +R  + +R  R    LS  ++  +    E        
Sbjct: 1541 -------RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593

Query: 362  SNSPIPPTQEDTDSDGE-----EPQLYFTEPQQLLDVFRELEEQNLSLIQNS-----QET 411
                +   Q+    +G+     E    F E +QLL   +E EEQ L   +       +E 
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL---QEREEQQLHRQERDRKFLEEEP 1650

Query: 412  EKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKG 471
            +   +E    L+H + R  RE  QL Q      +   + +    E E + R       + 
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR-------RQ 1703

Query: 472  DQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQ 531
            +++ K L+                +++    T Q     + +  ++LE  +  P+ + EQ
Sbjct: 1704 ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE-REEQ 1762

Query: 532  AERAKEKERRIRLREEKLQMQKILQEEHLQRARA----RAQAEIKKKRGRTLVCRSRPPA 587
              R +E++R+   REE+ Q+++  +E+ L+   +    R + +++++R      + RP  
Sbjct: 1763 QLRRQERDRK--FREEE-QLRQEREEQQLRSQESDRKFREEEQLRQEREEQ---QLRPQQ 1816

Query: 588  HRIKQQSEHTLMDKEEEE 605
               K + E   +  EE+E
Sbjct: 1817 RDGKYRWEEEQLQLEEQE 1834



 Score = 30.4 bits (67), Expect = 5.0
 Identities = 56/248 (22%), Positives = 100/248 (40%), Gaps = 42/248 (16%)

Query: 361 GSNSPIPPTQEDTDSDGEEPQ--LYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEEL 418
           G  S +   +++ D    EP+      EP Q     R+ +E+ L+  +   E ++ LE+ 
Sbjct: 105 GKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQR 164

Query: 419 SHTLKHTQIRMDREV-NQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKL 477
                    R D E+  Q ++W         +EE  A E +L++   H  E   D++   
Sbjct: 165 DRQ------RRDEELWRQRQEWQE-------REERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 478 LESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKE 537
              L    L++ R     +Q+              + D + +  E     K E   R +E
Sbjct: 212 RREL----LELRRKGREEKQQQR----------RERQDRVFQEEEEKEWRKRETVLRKEE 257

Query: 538 KERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHT 597
           +    +L+EE+ Q Q+ LQEE  Q  +   Q E++++       R      + + + E  
Sbjct: 258 E----KLQEEEPQRQRELQEEEEQLRKLERQ-ELRRE-------RQEEEQQQQRLRREQQ 305

Query: 598 LMDKEEEE 605
           L  K+EEE
Sbjct: 306 LRRKQEEE 313


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 114/547 (20%), Positives = 228/547 (41%), Gaps = 63/547 (11%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQ-LEDKQEDLEARAEAEH 123
            L  +ER+K ++E        + + +  +  +S+   SL+  L+ L + +E L    E+  
Sbjct: 1543 LLQEERDKLITE--------MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594

Query: 124  QRAFRDYTTWKLTLTKEKNVEPEN---MSGYIKQKRQMFLLQYALDVKRREIQRLETLAT 180
                 + T W+    K K ++ E    +  Y     +   +Q+ ++  R+E Q L     
Sbjct: 1595 SSKIAESTEWQ---EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR 1651

Query: 181  KEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV 240
              EA  +  EK L++     +E   +             K  K+K +KILE+ +   ++ 
Sbjct: 1652 STEANKKETEKQLQEAEQEMEEMKEK-----------MRKFAKSKQQKILELEEENDRL- 1699

Query: 241  NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNST 300
              ++E+    DT K   +        S KE LE  + ++  L K K  S  S++ S++  
Sbjct: 1700 --RAEVHPAGDTAKEC-METLLSSNASMKEELERVKMEYETLSK-KFQSLMSEKDSLSEE 1755

Query: 301  PGDKGPGIKG---KASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGG 357
              D    I+G   K +++ A E    +       T  +        S    ++P+ S   
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESV 1815

Query: 358  DSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEE 417
             S  + S  P   +D  S  +E   Y  +  QL +    LEE+     Q ++E  +TLE 
Sbjct: 1816 PS--AKSANPAVSKDFSSH-DEINNYLQQIDQLKERIAGLEEEK----QKNKEFSQTLEN 1868

Query: 418  LSHTLKHTQIRMDREVNQLKQWVTTM-MMSITKEEDTAAELELKARVFHFGEYKGDQQDK 476
              +TL       D E+  L++ VT M +++   +E+ +   +LK       E K D +++
Sbjct: 1869 EKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA---EEEKDDLEER 1925

Query: 477  LLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAK 536
            L+  L      +  +C    Q+     ++         +ELLE+   +  +K   +E  +
Sbjct: 1926 LMNQLAELNGSIGNYC----QDVTDAQIK---------NELLES--EMKNLKKCVSELEE 1970

Query: 537  EKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEH 596
            EK++ ++   EK +++  +++E+L++ +   +    K   + L    +     +KQ  + 
Sbjct: 1971 EKQQLVK---EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027

Query: 597  TLMDKEE 603
             +  +E+
Sbjct: 2028 CIRYQEK 2034



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 116/602 (19%), Positives = 239/602 (39%), Gaps = 96/602 (15%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQ---------LEDKQEDLEAR 118
            + R KA +E    K + +    + +++V A +  L+++LQ         ++ K EDLE R
Sbjct: 2068 EHRKKAQAELASFKVL-LDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126

Query: 119  AEAEHQRAFRDYTTW--KLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLE 176
             E   ++  ++      KL   + + V  E   G I         Q  L+ K +E+Q+L+
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI---------QVTLNKKDKEVQQLQ 2177

Query: 177  T---LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL--- 230
                    + A   ++  SL+ D     +  ++ +     A+++ E+E + K +      
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK 2237

Query: 231  -EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPK----------EWLEE-QEKK 278
             ++R ++  +  +K  ISR E   + ++       +L  K          E L + +E +
Sbjct: 2238 DQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETR 2297

Query: 279  HSFLKKAKEVSEASKE-SSVNSTPGDKGPGIKGKASSMWAKEG---------QGTKKPWR 328
            H +     E+++   E  S+     D    ++         EG         Q +K  + 
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE 2357

Query: 329  FLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTD-SDGEEPQLYFTEP 387
             L+T          +S +  S+  E      +   S +   +E    +  E  Q +  E 
Sbjct: 2358 QLET-------DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMM--- 444
            ++L ++  + EE+N+ L + +++      +L  TLK  +    ++  QL  +V +M    
Sbjct: 2411 KELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470

Query: 445  -----------------MSITKEED------TAAELELKARVFHFGEYKGDQQDKLLESL 481
                             +SI  E+D       A   +LK  +     +  D     L S 
Sbjct: 2471 NDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD-----LNSE 2525

Query: 482  NCKV-LDVYRHCTGTQQEANLGTVQMLTIIEHQL--DELLENLEHVPQVKIEQAERAKEK 538
            N K+  ++ ++     Q   +   Q   ++E QL  ++ LEN     + K++++E A E 
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585

Query: 539  ERRI--RLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEH 596
             RR    L+EEK  + K ++   +  ++   Q    ++ G   +  ++    ++K++  H
Sbjct: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ---LKVKEEEVH 2642

Query: 597  TL 598
             L
Sbjct: 2643 RL 2644



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 100/568 (17%), Positives = 228/568 (40%), Gaps = 48/568 (8%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRR-QLQLEDKQEDLE------ARAE 120
            +E  + L E+QQ+        + Y  K+SA   +++  +    + Q+DLE      A+A 
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067

Query: 121  AEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYAL--DVKRREIQRLETL 178
               ++A  +  ++K+ L   ++     ++  +K K+++   + ++   +K+++      L
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127

Query: 179  ATKEEARLERAEKSLEKDAALFDEFVR-ENDCSSVQA-MRAAEKETKAKIEK----ILEI 232
               EE  L+  +   EK  AL  E V  E     +Q  +   +KE +   E     + ++
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187

Query: 233  RDLTTQIVNIKSEISRFEDTLKHY-KVYKDFLYKLSPKEWLEEQEKKHSFLK-KAKEVSE 290
               T  + +++ +  R  D  K + + + D +   S +E +  +E   S LK + +++S 
Sbjct: 2188 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ--SKEEEIRLKEDNCSVLKDQLRQMSI 2245

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
              +E  +N +  +    I       W  + Q   +  + +     G +   LS  ++   
Sbjct: 2246 HMEELKINISRLEHDKQI-------WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQE 410
               SS  +     S +   ++         +    +   L  + R+ E      IQNS+ 
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD----IQNSKF 2354

Query: 411  TEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYK 470
            + + LE      +    R+  E+N  +Q + + ++S  +E    A  EL+ +  H  E K
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIIS-LLSGKEEAIQVAIAELRQQ--HDKEIK 2411

Query: 471  --------GDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLE 522
                     ++++ +LE  N K +D       T +      +Q     + QLD  ++++ 
Sbjct: 2412 ELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQ----KAQLDSFVKSMS 2467

Query: 523  HVPQVK---IEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTL 579
             +   +   +   ++ +E+   I L +++L  +   +   L+      ++ +        
Sbjct: 2468 SLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527

Query: 580  VCRSRPPAHRIKQQSEHTLMDKEEEELL 607
               +    +R       T+ D ++++LL
Sbjct: 2528 KLDAELIQYREDLNQVITIKDSQQKQLL 2555



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 112/542 (20%), Positives = 207/542 (38%), Gaps = 60/542 (11%)

Query: 65   LRDQERNKA-LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEH 123
            L+D+ + +  LSE ++ +     +   YS K     TS  +++++  KQ   E   E +H
Sbjct: 1019 LKDESKKEIPLSETERGEVEEDKENKEYSEKCV---TSKCQEIEIYLKQTISEKEVELQH 1075

Query: 124  QRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEE 183
             R  +D         +EK    E     +KQ  Q       L  K  +I  L+   ++ +
Sbjct: 1076 IR--KDL--------EEKLAAEEQFQALVKQMNQ------TLQDKTNQIDLLQAEISENQ 1119

Query: 184  ARLERAEKSLEKDAALFDE--FVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
            A +++   S   DA+  D    V+E    S     ++E       EKIL +     Q+  
Sbjct: 1120 AIIQKLITS-NTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKE-WLEEQ--EKKHSFLKKAKEVSEASKESSVN 298
                  + ++ L   K     L K   KE  L E+  ++K  + +  ++  E SKE   N
Sbjct: 1179 ------KLQEALTSRKA---ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKE---N 1226

Query: 299  STPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGD 358
               GD+   ++ +       +   T +      T  L   P + ++ Q  +QP   S   
Sbjct: 1227 ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGL-EEPLFKATEQHHTQPVLESN-- 1283

Query: 359  SRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEEL 418
                   + P       D    Q   T   Q+    +E+E + + L      T   L + 
Sbjct: 1284 -------LCPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335

Query: 419  SHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKL- 477
            S  +   Q +++++  +++   T    +    E    +LE         E+  + Q KL 
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395

Query: 478  -LESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAK 536
             L+ L  K  +   + +G   E      ++ T       E++E  + +  +  +   +AK
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQT-------EIIEQEDLIKALHTQLEMQAK 1448

Query: 537  EKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEH 596
            E + RI+  + +L   K   EE  + +RA+ Q  I++K    L+ R          Q E 
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEESRAKQQ--IQRKLQAALISRKEALKENKSLQEEL 1506

Query: 597  TL 598
            +L
Sbjct: 1507 SL 1508



 Score = 37.4 bits (85), Expect = 0.041
 Identities = 84/410 (20%), Positives = 161/410 (39%), Gaps = 31/410 (7%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            E  K +S   +     + QK+  S    A    LR      D+ + L ++ E +      
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413

Query: 129  DYTTWKLTLTKEKN--VEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARL 186
              +  +  LTK +   +E E++   +  + +M   ++   +K+ +++  E     EE   
Sbjct: 1414 QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473

Query: 187  E-RAEKSLEK--DAALFD--EFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
            E RA++ +++   AAL    E ++EN   S+Q   +  + T  ++ K L   D+ +Q+  
Sbjct: 1474 ESRAKQQIQRKLQAALISRKEALKEN--KSLQEELSLARGTIERLTKSLA--DVESQVSA 1529

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSF--LKKAKEVSEASKESSVNS 299
               E       L   +  +D L     +  LE Q    S   LK A E     KE  V  
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589

Query: 300  TPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQ------TMRLGRSPSYLSSPQQGSQPS- 352
                K   I    S+ W ++ +  +K +  L       +    R    + + +Q  Q   
Sbjct: 1590 IESLKSSKIA--ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647

Query: 353  ---ESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQ 409
                S+  + + +   +   +++ +   E+ + +    QQ +    ELEE+N  L     
Sbjct: 1648 GKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI---LELEEENDRLRAEVH 1704

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTM---MMSITKEEDTAAE 456
                T +E   TL  +   M  E+ ++K    T+     S+  E+D+ +E
Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE 1754



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 110/551 (19%), Positives = 212/551 (38%), Gaps = 79/551 (14%)

Query: 73   ALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTT 132
            ALSE + Q   +V ++++  +++ A+   L   L   ++Q  L+  ++  H     +   
Sbjct: 741  ALSEERDQLLSQV-KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIH 799

Query: 133  WKLTLTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRREI----QRLETLAT 180
                  K K+V+ E +   +   +  F         LQ  L  K  E+    +R+  +++
Sbjct: 800  SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859

Query: 181  KEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIR-DLTTQI 239
            K E  L +A    E +    D+ + E      + +   ++  + K +++ EI   +T ++
Sbjct: 860  KVE-ELSQALSQKELEITKMDQLLLEKK----RDVETLQQTIEEKDQQVTEISFSMTEKM 914

Query: 240  VNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNS 299
            V +  E  +F   ++  K  K+ L  LS  E     E K   +++  EVS   K++    
Sbjct: 915  VQLNEE--KFSLGVE-IKTLKEQLNLLSRAE-----EAKKEQVEEDNEVSSGLKQNYDEM 966

Query: 300  TP-GDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGG- 357
            +P G            +  KE +  K   R LQ   + R        Q+ S+  E     
Sbjct: 967  SPAGQISKEELQHEFDLLKKENEQRK---RKLQAALINRKELL----QRVSRLEEELANL 1019

Query: 358  -DSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLE 416
             D      P+  T+     + +E + Y  +      V  + +E  + L Q   E E  L+
Sbjct: 1020 KDESKKEIPLSETERGEVEEDKENKEYSEKC-----VTSKCQEIEIYLKQTISEKEVELQ 1074

Query: 417  ELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAEL-ELKARVFHFGEYKGDQQD 475
             +   L+      ++    +KQ   T+     + +   AE+ E +A +        D  D
Sbjct: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134

Query: 476  KLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERA 535
                +L  + + +   CTG+               EH   EL                  
Sbjct: 1135 GDSVALVKETVVISPPCTGSS--------------EHWKPEL------------------ 1162

Query: 536  KEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
              +E+ + L +EK Q+QK LQE    R     +A+ K++  R  + + +   +R+++Q +
Sbjct: 1163 --EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220

Query: 596  HTLMDKEEEEL 606
                 KE E +
Sbjct: 1221 E--QSKENENI 1229



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 122/627 (19%), Positives = 225/627 (35%), Gaps = 104/627 (16%)

Query: 11   KNMTNDKNSLESMNISSSSSTEENPKKQARKNE------EHGPDPSANPFHLSGDVD--- 61
            + +  +  SL+S  I+ S+  +E  K+  ++ E      E+  + +    H+   V    
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643

Query: 62   ---FFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEAR 118
               +  LR  E NK  +E+Q Q+  +  ++M    +  AK +  ++ L+LE++ + L A 
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK-SKQQKILELEEENDRLRAE 1702

Query: 119  AEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETL 178
                   A     T   +    K         Y    ++   L    D    E+Q L+  
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762

Query: 179  A---TKEEARLERAEKS------LEKDAALFDEFVREND---------CS-SVQAMRAAE 219
                  ++A LE  EK        E+          E D         CS SV + ++A 
Sbjct: 1763 IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822

Query: 220  KETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKD--------FLYKLSPKE- 270
                       EI +   QI  +K  I+  E+  +  K +           L ++S K+ 
Sbjct: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDG 1882

Query: 271  ---WLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPW 327
                L+E+  K + L +  +  E S+ + +  T  ++   ++ +  +  A+         
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQ-EELSRVTKLKETAEEEKDDLEERLMNQLAELN------- 1934

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
                    G   +Y          +E    + +     +   +E      E+ QL     
Sbjct: 1935 --------GSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE------EKQQLV---- 1976

Query: 388  QQLLDVFRELEEQNLSLIQNSQE---TEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMM 444
            ++   V  E+ ++ L  IQ +Q+    +   +EL   LK  Q    +EV QL++      
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ----QEVKQLQKDCIRYQ 2032

Query: 445  MSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTV 504
              I+  E T   LE          +   +  K LE     +     H    Q E     V
Sbjct: 2033 EKISALERTVKALE----------FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV 2082

Query: 505  QMLTIIEHQLDELLENLE-------HVPQVKIEQAERAKEKERRIRLREEK-LQMQKILQ 556
             +          L +NL+       +   VK +  ++ ++ ERR+   EEK L+ +K +Q
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142

Query: 557  EE---------HLQRARARAQAEIKKK 574
            E+         HL+      Q  + KK
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKK 2169



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 115/648 (17%), Positives = 246/648 (37%), Gaps = 125/648 (19%)

Query: 9    VSKNMTNDKNSLESMNISSSSS-------TEENPKKQARKNEEHGPDPSANPFHLSGDVD 61
            + K + ++K S++S                EE   K+ +  +E          HL   + 
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160

Query: 62   FFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEA 121
               +   +++K + + Q+     V Q   ++  +S+          L+D ++ +   A+ 
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSS----------LQDDRDRVIDEAK- 2209

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            + +R F D    K    +E  ++ +N S    Q RQM +    L +    I RLE     
Sbjct: 2210 KWERKFSDAIQSK---EEEIRLKEDNCSVLKDQLRQMSIHMEELKIN---ISRLEH---- 2259

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL--------EIR 233
                    +K + +  A  +  +++  C ++Q      KE  +++E+          E+ 
Sbjct: 2260 --------DKQIWESKAQTEVQLQQKVCDTLQG---ENKELLSQLEETRHLYHSSQNELA 2308

Query: 234  DLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSF------LKKAKE 287
             L +++ ++K +++   ++L+  K  K  L  +  ++  + Q  K S+      L+ ++E
Sbjct: 2309 KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368

Query: 288  VSEA------SKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSY 341
            ++         KE  + S    K   I+   + +  +  +  K+              + 
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE------------LENL 2416

Query: 342  LSSPQQGSQPSESSGGDSRGSNSPIPPT-----------QEDTDSDGEEPQLYFTEPQQL 390
            LS  ++ +   E     +    + +  T           +   DS  +       +  ++
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476

Query: 391  LDVFRELEEQNLSLI--------QNSQETEKTLEEL----SHT--LKHTQIRMDREV--- 433
            +  +++LEE++LS+I        + + E  K  EE+    SH   L     ++D E+   
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536

Query: 434  ------------NQLKQWVTTMMMSITKEEDTAAELELKARVFH---------FGEYKGD 472
                        +Q KQ +   +    + E+  A+LE K +            F   + +
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596

Query: 473  QQD--KLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIE 530
            +QD  K +ESL   +  + R  T  Q+E  LG       ++ +    L  L    Q +I 
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA 2656

Query: 531  QAER---AKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKR 575
            + E      +KE   ++ E + +++K L+  H      R + E  ++R
Sbjct: 2657 ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 87/498 (17%), Positives = 199/498 (39%), Gaps = 62/498 (12%)

Query: 68  QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAF 127
           QE+ + +S  Q Q T    ++   SS    +   +++QLQ   ++E+  +  +A+  +  
Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ---EKEEFISTLQAQLSQTQ 210

Query: 128 RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLE 187
            +    ++   K+   E +        + ++  L    DV+    Q+L  L    + +LE
Sbjct: 211 AEQAAQQVVREKDARFETQ----VRLHEDELLQLVTQADVETEMQQKLRVL----QRKLE 262

Query: 188 RAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEIS 247
             E+SL   A + D   +E        + AAE+  +           L+ Q+  +++E +
Sbjct: 263 EHEESLVGRAQVVDLLQQE--------LTAAEQRNQI----------LSQQLQQMEAEHN 304

Query: 248 RFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPG 307
              +T++  +     L +   K  LE  E+K SF    +E+    ++       G     
Sbjct: 305 TLRNTVETEREESKILLE---KMELEVAERKLSFHNLQEEMHHLLEQF---EQAGQAQAE 358

Query: 308 IKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIP 367
           ++ + S++  K                +    S++ S Q+  Q  +S+    +  NS + 
Sbjct: 359 LESRYSALEQK------------HKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL- 405

Query: 368 PTQEDTDSDGEEPQLYFTEPQQLLDVFRELEE--QNLSLIQNSQETEKTLEELSH----- 420
             Q+  +   +  Q       QL    +E+ +    L L Q+   ++ +  ++ +     
Sbjct: 406 -LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464

Query: 421 TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             +     + + V +L+     +++S  + E+  AE E  +      E +    +   E 
Sbjct: 465 VTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREV 524

Query: 481 LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQ-----LDELLENLEHVPQVKIE-QAER 534
               ++D+    + + +E+    ++     +H+     L E+ E  E +  +K++ Q +R
Sbjct: 525 SEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKR 584

Query: 535 AKEKERRIRLREEKLQMQ 552
           A+E +  +  ++E  QM+
Sbjct: 585 AEEADHEVLDQKEMKQME 602



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 64/314 (20%), Positives = 132/314 (42%), Gaps = 28/314 (8%)

Query: 176 ETLATKEEARLERAEKSLEKDAALF--DEFVRENDCSSVQAMRAAEKETKAKIEKILE-I 232
           E LA  E+  +E  +   +KD  L   DE ++E   ++   ++  +   KAK+  + + I
Sbjct: 52  ERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYI 111

Query: 233 RDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEAS 292
            ++  Q   +     + E+ L  +        K S +E +E ++ KH   +K + +S  +
Sbjct: 112 EEMKAQGGTVLPTEPQSEEQLSKHD-------KSSTEEEMEIEKIKHKLQEKEELIS--T 162

Query: 293 KESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPS 352
            ++ +     ++ P         +    Q  ++   F+ T++   S +      Q     
Sbjct: 163 LQAQLTQAQAEQ-PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221

Query: 353 ESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVF-RELEEQNLSLIQNSQET 411
           + +  +++         Q  T +D E      TE QQ L V  R+LEE   SL+  +Q  
Sbjct: 222 KDARFETQVRLHEDELLQLVTQADVE------TEMQQKLRVLQRKLEEHEESLVGRAQVV 275

Query: 412 EKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA------AELELKARVFH 465
           +   +EL+   +  QI + +++ Q++    T+  ++  E + +       ELE+  R   
Sbjct: 276 DLLQQELTAAEQRNQI-LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334

Query: 466 FGEYKGDQQDKLLE 479
           F   + ++   LLE
Sbjct: 335 FHNLQ-EEMHHLLE 347



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 42/255 (16%), Positives = 108/255 (42%), Gaps = 25/255 (9%)

Query: 358 DSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQN--SQETEKTL 415
           + +     + PT+  ++    +     TE +  ++  +   ++   LI    +Q T+   
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQA 172

Query: 416 EE--LSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEE-DTAAELELKARVFHFGEYKGD 472
           E+   S T     + M +++ + +++++T+   +++ + + AA+  ++ +   F      
Sbjct: 173 EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232

Query: 473 QQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQA 532
            +D+LL+ +             TQ +      Q L +++ +L+E  E+L    QV     
Sbjct: 233 HEDELLQLV-------------TQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQ 279

Query: 533 ERAKEKERRIRLREEKLQMQKILQEEHLQRARA----RAQAEIKKKRGRTLVCRSRPPAH 588
           +     E+R ++  ++LQ    ++ EH          R +++I  ++    V   +   H
Sbjct: 280 QELTAAEQRNQILSQQLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336

Query: 589 RIKQQSEHTLMDKEE 603
            ++++  H L   E+
Sbjct: 337 NLQEEMHHLLEQFEQ 351


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 124/600 (20%), Positives = 240/600 (40%), Gaps = 105/600 (17%)

Query: 28   SSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQ 87
            S+   EN K+Q  +  E      +N      D     ++ Q++ K L  R ++    +  
Sbjct: 1068 STMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEA 1127

Query: 88   KMTYSSKVSAKHTSLRRQLQ-----LEDK------QEDLEARAEAEHQRAFRDYTTWKLT 136
            +    +K   + + L R+L+     LE+       Q +L  + EAE Q+  RD       
Sbjct: 1128 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL------ 1181

Query: 137  LTKEKNVEPENMSGYIKQKR--QMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLE 194
              +E  ++ E M   +++K    M  L   +D  +R  Q+LE    K E ++E  + S  
Sbjct: 1182 --EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK--EKSELKMETDDLSSN 1237

Query: 195  KDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLK 254
             +A    +   E  C S++  + +E +TK + ++ L I DLT Q   +++E   +     
Sbjct: 1238 AEAISKAKGNLEKMCRSLED-QVSELKTKEEEQQRL-INDLTAQRARLQTEAGEYS---- 1291

Query: 255  HYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASS 314
                             L+E++   S L ++K+ S    E   +    +       KA +
Sbjct: 1292 ---------------RQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET------KAKN 1330

Query: 315  MWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTD 374
              A   Q ++     L+              Q+G    + +   +   NS +   +   +
Sbjct: 1331 ALAHALQSSRHDCDLLREQ--------YEEEQEGKAELQRALSKA---NSEVAQWRTKYE 1379

Query: 375  SDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH---TLKHTQIRMDR 431
            +D              +    ELEE    L Q  QE E+ +E ++    +L+ T+ R+  
Sbjct: 1380 TDA-------------IQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426

Query: 432  EVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRH 491
            EV  L       M+ + +     A L+ K R F          DK+L     K  +    
Sbjct: 1427 EVEDL-------MLDVERSNAACAALDKKQRNF----------DKVLSEWKQKYEETQAE 1469

Query: 492  CTGTQQEANLGTVQML---TIIEHQLDELLENL----EHVPQVKIEQAERAKEKERRIRL 544
               +Q+E+   + ++     + E  LD+L E L    +++ Q   +  E+  E  ++I  
Sbjct: 1470 LEASQKESRSLSTELFKVKNVYEESLDQL-ETLRRENKNLQQEISDLTEQIAEGGKQIH- 1527

Query: 545  REEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
              EK++ Q   ++  +Q A   A+A ++ + G+ L  R +   +++K + +  + +K+EE
Sbjct: 1528 ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL--RIQLELNQVKSEVDRKIAEKDEE 1585



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 117/593 (19%), Positives = 230/593 (38%), Gaps = 98/593 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQ-LEDKQEDLEARAEAEH---- 123
            +R + L E +++   R+ +   +   V+AK  SL +  Q L+++ EDL    E  +    
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443

Query: 124  -----QRAF-RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLET 177
                 QR F +  + WK    +E   E E       QK    L      VK    + L+ 
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKY-EETQAELE-----ASQKESRSLSTELFKVKNVYEESLDQ 1497

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVREN--DCSSVQAMRAAEKETKAKIEKILEIRDL 235
            L T     L R  K+L+++ +   E + E       ++ ++   ++ K +I+  LE  + 
Sbjct: 1498 LET-----LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552

Query: 236  TTQ-----IVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
            + +     I+ I+ E+++ +  +      KD        E +++ ++ H+ + +  + + 
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKD--------EEIDQLKRNHTRVVETMQSTL 1604

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMR-----LGRSPSYLSSP 345
             ++  S N     K   ++G  + M  +     +     L+  R     L  +  +L   
Sbjct: 1605 DAEIRSRNDALRVKKK-MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663

Query: 346  QQGSQP-SESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRE---LEEQN 401
             +G +   E      R +N      +E   +  +  +      Q+LLD       L  QN
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723

Query: 402  LSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM---SITKEEDTAAELE 458
             SLI   ++ E  + +L   ++           + K+ +T   M    + KE+DT+A LE
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783

Query: 459  LKARVFHFG----EYKGDQQDKL--------LESLNCKVLDVYRHCTGTQQEANLGTVQM 506
               +         +++ D+ ++L        ++ L  +V ++       +Q+ N   V+ 
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN-EQKRNAEAVKG 1842

Query: 507  LTIIEHQLDEL-------------LENLEHVPQVKIE----QAERAKEKERRIRLREEKL 549
            L   E ++ EL             L++L    Q K++    QAE A+E+      +  KL
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKL 1902

Query: 550  QMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKE 602
            Q         L+ A  RA            +  S+    R+K +  HT +  E
Sbjct: 1903 Q-------HELEEAEERAD-----------IAESQVNKLRVKSREVHTKISAE 1937



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 55/255 (21%), Positives = 105/255 (41%), Gaps = 42/255 (16%)

Query: 65   LRDQERNKALSERQ----QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEAR-A 119
            L   ER++ ++E++     ++   +H + T       K  +   QLQ E ++   E+R A
Sbjct: 1695 LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNA 1754

Query: 120  EAEHQRAFRDYTTWKLTLTKEKNVEP------ENMSGYIK--QKRQMFLLQYALDVKRRE 171
            E + ++A  D       L KE++         +N+   +K  Q R     Q AL   +++
Sbjct: 1755 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQ 1814

Query: 172  IQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILE 231
            IQ+LE    + E  +E  +K                +  +V+ +R  E+           
Sbjct: 1815 IQKLEARVRELEGEVENEQK---------------RNAEAVKGLRKHER----------R 1849

Query: 232  IRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH--SFLKKAKEVS 289
            +++LT Q    +  + R +D +   +  K   YK   +E  EEQ   +   F K   E+ 
Sbjct: 1850 VKELTYQTEEDRKNVLRLQDLVDKLQA-KVKSYKRQAEE-AEEQSNANLSKFRKLQHELE 1907

Query: 290  EASKESSVNSTPGDK 304
            EA + + +  +  +K
Sbjct: 1908 EAEERADIAESQVNK 1922



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 101/529 (19%), Positives = 212/529 (40%), Gaps = 53/529 (10%)

Query: 79   QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQ-----EDLE---ARAEAE-------- 122
            + K   V ++     +++A+ T+ +R+L+ E  +     +DLE   A+ E E        
Sbjct: 919  EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 978

Query: 123  ----HQRAFRDYTTWKLTLTKE--KNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLE 176
                 + A  D T  KL+  K+  +    + +     ++ ++ +L  A     +++  LE
Sbjct: 979  KNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLE 1038

Query: 177  -TLATKEEAR--LERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIR 233
             +L  +++ R  LERA++ LE D  L  E   + +    Q     EK       K  EI 
Sbjct: 1039 GSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK-------KEFEIS 1091

Query: 234  DLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASK 293
            +L ++I + ++   + +  +K  +   + L +       E + ++ S  K  K+ S+ S+
Sbjct: 1092 NLISKIEDEQAVEIQLQKKIKELQARIEELGE-------EIEAERASRAKAEKQRSDLSR 1144

Query: 294  ESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSE 353
            E    S   ++  G       +  K     +K  R L+   L +  + +++ ++    S 
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL-QHEAMVAALRKKHADSM 1203

Query: 354  SSGGDSRGSNSPIPPTQE--------DTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLI 405
            +  G+   +   +    E        +TD      +        L  + R LE+Q   L 
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELK 1263

Query: 406  QNSQETEKTLEELSHTLKHTQIRMDREVNQL-KQWVTTMMMSITKEEDTAAELELKARVF 464
               +E ++ + +L+      Q        QL ++      +S +K+  T    ELK ++ 
Sbjct: 1264 TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLE 1323

Query: 465  HFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHV 524
               + K      L  S +    D+ R     +QE      + L+    ++ +     E  
Sbjct: 1324 EETKAKNALAHALQSSRH--DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1381

Query: 525  PQVKIEQAERAKEKERRIRLREEKLQMQKILQE-EHLQRARARAQAEIK 572
               + E+ E AK+K  + RL+E +  ++ +  +   L++ + R Q E++
Sbjct: 1382 AIQRTEELEEAKKKLAQ-RLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2158

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2217

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2218 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2258

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2259 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2355

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2416 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2447

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2508 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2563

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2564 EGVRRKQEE 2572



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1841 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1894 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1940

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 2001 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2060 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2109

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2166

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVE 2185



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2313

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2374 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2432 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2486 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2591

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1577 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1624

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1685 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1801

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1862 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1909

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1910 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2024

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2025 RERAEQESARQLQLAQE 2041



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1515



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1470

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1528

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1631



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1337 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1392

Query: 574  KRGR 577
             + R
Sbjct: 1393 LQQR 1396


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2162

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2221

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2222 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2262

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2263 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2300

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2359

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2419

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2420 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2451

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2452 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2511

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2512 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2567

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2568 EGVRRKQEE 2576



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1665 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1845 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1898 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1944

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 2005 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2064 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2113

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2170

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2171 MEKHKKFAEQTLRQKAQVE 2189



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2317

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2378 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2436 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2490 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2539

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2540 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2595

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2596 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2638



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1581 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1628

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1629 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1688

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1689 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1805

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1866 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1913

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1914 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2028

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2029 RERAEQESARQLQLAQE 2045



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1468 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1519



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1474

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1532

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1635



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1341 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1396

Query: 574  KRGR 577
             + R
Sbjct: 1397 LQQR 1400


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2158

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2217

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2218 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2258

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2259 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2296

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2355

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2416 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2447

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2448 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2507

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2508 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2563

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2564 EGVRRKQEE 2572



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1841 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1894 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1940

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 2001 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2060 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2109

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2166

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVE 2185



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2313

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2374 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2432 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2486 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2591

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2634



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1577 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1624

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1625 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1684

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1685 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1801

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1862 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1909

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1910 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2024

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2025 RERAEQESARQLQLAQE 2041



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1464 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1515



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1470

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1528

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1631



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1337 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1392

Query: 574  KRGR 577
             + R
Sbjct: 1393 LQQR 1396


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2126

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2185

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2186 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2226

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2227 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2264

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2323

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2383

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2384 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2415

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2416 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2475

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2476 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2531

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2532 EGVRRKQEE 2540



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1629 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1809 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1862 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1908

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 1969 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2028 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2077

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2134

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2135 MEKHKKFAEQTLRQKAQVE 2153



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2281

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2342 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2400 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2454 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2503

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2504 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2559

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2560 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2602



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1545 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1592

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1593 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1652

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1653 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1769

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1830 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1877

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1878 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 1992

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 1993 RERAEQESARQLQLAQE 2009



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1432 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1483



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1438

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1496

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1599



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1305 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1360

Query: 574  KRGR 577
             + R
Sbjct: 1361 LQQR 1364


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2295

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2354

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2355 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2395

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2396 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2433

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2492

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2552

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2553 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2584

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2644

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2645 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2700

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2701 EGVRRKQEE 2709



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1798 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1978 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 2031 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 2077

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 2138 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2197 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2246

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2303

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2304 MEKHKKFAEQTLRQKAQVE 2322



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2450

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2511 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2569 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2623 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2672

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2728

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2729 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1714 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1761

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1762 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1821

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1822 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1938

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1999 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 2046

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 2047 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2161

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2162 RERAEQESARQLQLAQE 2178



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1601 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1652



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1607

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1665

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1768



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1474 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1529

Query: 574  KRGR 577
             + R
Sbjct: 1530 LQQR 1533


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2136

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2195

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2196 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2236

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2237 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2274

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2333

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2393

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2394 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2425

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2485

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2486 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2541

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2542 EGVRRKQEE 2550



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1639 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1819 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1872 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1918

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 1979 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2038 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2087

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2144

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2145 MEKHKKFAEQTLRQKAQVE 2163



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2291

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2352 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2410 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2464 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2513

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2514 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2569

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2570 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1555 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1602

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1603 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1662

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1663 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1779

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1840 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1887

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1888 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2002

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2003 RERAEQESARQLQLAQE 2019



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1442 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1493



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1448

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1506

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1609



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1315 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1370

Query: 574  KRGR 577
             + R
Sbjct: 1371 LQQR 1374


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2144

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2203

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2204 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2244

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2245 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2282

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2341

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2401

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2402 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2433

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2434 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2493

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2494 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2549

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2550 EGVRRKQEE 2558



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1647 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1706

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1827 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1879

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1880 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1926

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1986

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 1987 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2046 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2095

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2152

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2153 MEKHKKFAEQTLRQKAQVE 2171



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2299

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2360 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2418 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2472 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2521

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2522 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2577

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2578 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2620



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1563 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1610

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1611 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1670

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1671 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1787

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1848 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1895

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1896 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2010

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2011 RERAEQESARQLQLAQE 2027



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1450 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1501



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1456

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1514

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1617



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1323 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1378

Query: 574  KRGR 577
             + R
Sbjct: 1379 LQQR 1382


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 107/549 (19%), Positives = 215/549 (39%), Gaps = 90/549 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            ER  A S RQ ++  R+ Q     ++  A+  +   +L+ E +QE    RA+AE Q A R
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-RAQAE-QAALR 2185

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD-------VKRREIQRLETLATK 181
                    + K K    + +    + ++++  L+  L+       +   E+QRL+  AT 
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT- 2244

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                 E A +  + +  LF   V+  + S ++A   AE        + L +RD       
Sbjct: 2245 -----EAARQRSQVEEELFSVRVQMEELSKLKARIEAEN-------RALILRD------- 2285

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESS-VNST 300
             K    RF                       EE EK     ++A  +S A++E++ +   
Sbjct: 2286 -KDNTQRFLQ---------------------EEAEKMKQVAEEAARLSVAAQEAARLRQL 2323

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
              +     +  A  M  ++ Q  ++  R      L +    L+  +Q  +  E     ++
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ-EQARRLQEDKEQMAQ 2382

Query: 361  GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH 420
                     Q   +++ +       E ++L     E+        +++Q   K  EE+  
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2442

Query: 421  TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLES 480
             L  T++    +V        T++ ++                    E +  Q D   E 
Sbjct: 2443 KLHRTELATQEKV--------TLVQTL--------------------EIQRQQSDHDAER 2474

Query: 481  LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKER 540
            L   + ++ R     QQEA L  ++   +   Q ++LL+  + + Q  + + +   ++ER
Sbjct: 2475 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER 2534

Query: 541  RIRLREEKLQMQKILQEE-----HLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
             I   +EK +++++ Q+E      L+  + R Q +++++R R +   S   A R + ++E
Sbjct: 2535 FI--EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA--SMEEARRRQHEAE 2590

Query: 596  HTLMDKEEE 604
              +  K+EE
Sbjct: 2591 EGVRRKQEE 2599



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 103/559 (18%), Positives = 211/559 (37%), Gaps = 54/559 (9%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRA 126
            + E+ K  +ER+ ++  +  ++     +++ +    +RQL     Q+ L A  E    RA
Sbjct: 1688 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1747

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEAR- 185
              +    +  L +E+    +  +    QKRQ    + A      E+        +EE+R 
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 186  -LERAEKSLEKDA--------------ALFDEFVRENDCSSVQAMRAAEKETKAKIEKIL 230
              E++++ LE +A              AL +E  R+   +   A R   +  +   EK+ 
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
             I + T     +K+E    E  LK  +   + L +L+  E  + +  +    +   ++ E
Sbjct: 1868 AIGEAT----RLKTEA---EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEG--QGTKKPWRFLQTMRLGRSPSYLSSPQQG 348
               +              K   S +  ++G  + T +  R ++   L    S+      G
Sbjct: 1921 RLAQLR------------KASDSELERQKGLVEDTLRQRRQVEEEILALKASF-EKAAAG 1967

Query: 349  SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNS 408
                E   G  R +      ++E  + +    +    E ++      E  +++L+  + +
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027

Query: 409  QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKE-EDTAAELELKARVFHFG 467
                K   E    LK  ++   R + +  +  +   + + +E      + E KA  F   
Sbjct: 2028 ARQRKAALEEVERLK-AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
            + + + Q  L +  +  VLD  R      + A     +     E +  +         + 
Sbjct: 2087 QKEQELQQTLQQEQS--VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ--------SRR 2136

Query: 528  KIEQAERAKEK-ERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
            ++E+AER K+  E + + R +     + L++E  Q A  RAQAE    R +     +   
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQ---AADAE 2193

Query: 587  AHRIKQQSEHTLMDKEEEE 605
              + K+ +E TL  K + E
Sbjct: 2194 MEKHKKFAEQTLRQKAQVE 2212



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 81/403 (20%), Positives = 161/403 (39%), Gaps = 59/403 (14%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLED--KQEDLEARAEA 121
            +LRD++  +   + + +K  +V ++    S V+A+  +  RQL  ED  +Q  L  +   
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLS-VAAQEAARLRQLAEEDLAQQRALAEKMLK 2340

Query: 122  EHQRAFRDYTTWKLT---LTKEKNVEPENMSGYIKQKRQMFL--------LQYALDVKRR 170
            E  +A ++ T  K     L ++K +  E      + K QM           Q  L+ +R+
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400

Query: 171  EIQRLETLATKEE-----ARLERAEKSLEKDAALF-------------DEFVRENDCSSV 212
              ++LE  A  E      A + RA+   E+DA  F              E   +   + V
Sbjct: 2401 --RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458

Query: 213  QAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWL 272
            Q +    +++    E++ E       I  ++ E  + +   K  ++  + +  +  ++ L
Sbjct: 2459 QTLEIQRQQSDHDAERLREA------IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512

Query: 273  EE-QEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMW----AKEGQGTKKPW 327
            +E Q  + SFL +   + +  +E  +           K K   ++    AK  Q  ++  
Sbjct: 2513 QETQALQQSFLSEKDSLLQ--RERFIEQE--------KAKLEQLFQDEVAKAQQLREEQQ 2562

Query: 328  RFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP 387
            R  Q M   R     S  +   +  E+  G  R         Q+      ++ +L   E 
Sbjct: 2563 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRRQQEELLAEEN 2618

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMD 430
            Q+L +  + LEEQ+ + + +S+E   +    + TL + +  +D
Sbjct: 2619 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2661



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 100/557 (17%), Positives = 227/557 (40%), Gaps = 50/557 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKH---TSLRRQLQLEDKQEDLEARAEA 121
            L  + + +A + R++Q+ ++  +++   ++ + +      + R  Q++   E  +  AEA
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
            E Q     +   + T   E++++ E+++  + Q R+        + +RR  Q+ E    +
Sbjct: 1604 ELQSKRASFA--EKTAQLERSLQEEHVA--VAQLRE--------EAERRAQQQAEAERAR 1651

Query: 182  EEARLERAEKSLEKDAAL-----FDEFVRENDCSSVQAMR---AAEKETKAK---IEKIL 230
            EEA  E     L+ + AL      +E  ++   +  +A +    AE+E + +    E+ +
Sbjct: 1652 EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV 1711

Query: 231  EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
              R+L  Q +  + +++  E T +     +  L +L  +    EQ+++    + A+   E
Sbjct: 1712 RQRELAEQELEKQRQLA--EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
            A+  +        +   ++ +   + A + +  ++  R        R  +     ++ ++
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEES-RSTSEKSKQRLEAEAGRFRELAE 1828

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLL-DVFRELEEQNLSLIQNSQ 409
             +      +  +       +ED      E +    E    + +  R   E  ++L +   
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEY 469
            E E+ L  L+      + R++ +  Q K  +   +  + K  D+  E +           
Sbjct: 1889 ENER-LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ----------- 1936

Query: 470  KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLENLEHVPQ 526
            KG  +D L +    +V +       + ++A  G  ++   L  I    ++ L + E    
Sbjct: 1937 KGLVEDTLRQ--RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 527  VKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPP 586
                Q + A E+ERR R  EE++Q + +  EE   R R  A  E+++ + +  V  +R  
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQ-KSLAAEEEAARQRKAALEEVERLKAK--VEEARRL 2051

Query: 587  AHRIKQQSEHTLMDKEE 603
              R +Q+S   L   +E
Sbjct: 2052 RERAEQESARQLQLAQE 2068



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 13/118 (11%)

Query: 496  QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE-------RAKEKERRIRLREEK 548
            ++EA +   Q    I+ +L +L ++ E   Q K  QAE       R +E+ R +RL+ E 
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490

Query: 549  LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
             + Q+   E  LQ  RARA+    +KR      +++  A R+++Q +     K + E+
Sbjct: 1491 TERQRGGAEGELQALRARAEEAEAQKR------QAQEEAERLRRQVQDESQRKRQAEV 1542



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 51/231 (22%), Positives = 96/231 (41%), Gaps = 42/231 (18%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTA 454
            R ++E+   L Q+S+   +     +   + +++R++ E+      V  + +  T+ +   
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-----VVRLQLEATERQRGG 1497

Query: 455  AELELKARVFHFGEYKGD--QQDKLLESLNCKVLDVYRHCTGTQQEANLGT--------- 503
            AE EL+A      E +    Q  +  E L  +V D  +     Q E  L +         
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAA 1555

Query: 504  ------VQMLTIIEHQLDELLENLEHVP-------QVKIEQAERAKEKE---RRIRLREE 547
                  +Q L  +  Q +E    L           QV +E A+R+ E E   +R    E+
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615

Query: 548  KLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL 598
              Q+++ LQEEH+  A+ R +AE +         + +  A R ++++E  L
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERR--------AQQQAEAERAREEAEREL 1658



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%)

Query: 514  LDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKK 573
            + E L  +E   + ++ + +RA+E+ER   + E  L+ Q+ L E H Q A+A+A+ E K+
Sbjct: 1364 ISETLRRMEE--EERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQ-AKAQAEREAKE 1419

Query: 574  KRGR 577
             + R
Sbjct: 1420 LQQR 1423


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 126/581 (21%), Positives = 234/581 (40%), Gaps = 105/581 (18%)

Query: 65   LRDQERNKA-LSERQQQKTMRVHQKMTYSSKVSAKHT-SLRRQLQLEDKQ---EDLEARA 119
            + D E +K  L E+ ++K   ++Q+   +SK+  +   +L+ Q +L++ Q   E+LE   
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQ---NSKIEDEQVLALQLQKKLKENQARIEELEEEL 1124

Query: 120  EAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRR-EIQRLETL 178
            EAE     R        L  + + E E +S  +++      +Q  ++ KR  E Q++   
Sbjct: 1125 EAE-----RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179

Query: 179  ATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT- 237
              +   + E    +L K  A   + V E         R  +K  K K E  LE+ D+T+ 
Sbjct: 1180 LEEATLQHEATAAALRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236

Query: 238  --QIVNIKSEISR----FEDTLKHYKV--------YKDFLYKLSPKEW--------LEEQ 275
              QI+  K+ + +     ED    Y+V          DF  + +  +         LEE+
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296

Query: 276  EKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRL 335
            E   S L + K       E        +      GKA +  A   Q  +     L+    
Sbjct: 1297 EALISQLTRGKLSYTQQMEDLKRQLEEE------GKAKNALAHALQSARHDCDLLR---- 1346

Query: 336  GRSPSYLSSPQQGSQPSESSGGDSR---GSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLD 392
                      +Q  + +E+     R    +NS +   +   ++D              + 
Sbjct: 1347 ----------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA-------------IQ 1383

Query: 393  VFRELEEQNLSLIQNSQETEKTLEELS---HTLKHTQIRMDREVNQLKQWVTTMMMSITK 449
               ELEE    L Q  Q+ E+ +E ++    +L+ T+ R+  E+  L       M+ + +
Sbjct: 1384 RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL-------MVDVER 1436

Query: 450  EEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTI 509
                AA L+ K R F          DK+L     K  +       +Q+EA   + ++  +
Sbjct: 1437 SNAAAAALDKKQRNF----------DKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486

Query: 510  IEHQLDELLENLEHVPQVKIEQAERAKEKERRI-----RLRE-EKLQMQKILQEEHLQRA 563
             ++  +E LE+LE   +      E   +   ++      + E EK++ Q  +++  LQ A
Sbjct: 1487 -KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545

Query: 564  RARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
               A+A ++ + G+ L  R++   ++IK + E  L +K+EE
Sbjct: 1546 LEEAEASLEHEEGKIL--RAQLEFNQIKAEIERKLAEKDEE 1584



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 111/573 (19%), Positives = 218/573 (38%), Gaps = 63/573 (10%)

Query: 74   LSERQQQKTMRVHQKMTYSSKVSAKHT--SLRRQLQLEDKQEDLEARAEAEHQR----AF 127
            LS  QQ + ++   +    +K +  H   S R    L  +Q + E  A+AE QR    A 
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367

Query: 128  RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFL-LQYALDVKRREIQRLETLATKEEARL 186
             +   W+     +     E +    K+  Q     + A++    +   LE    + +  +
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI 1427

Query: 187  ERAEKSLEKD---AALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIK 243
            E     +E+    AA  D+  R  D    +  +  E+          E R L+T++  +K
Sbjct: 1428 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK 1487

Query: 244  SEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGD 303
            +    +E++L+H + +K     L  +E  +  E+     K   E+ +  K+  V     +
Sbjct: 1488 NA---YEESLEHLETFKRENKNLQ-EEISDLTEQLGEGGKNVHELEKVRKQLEVEKL--E 1541

Query: 304  KGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSN 363
                ++   +S+  +EG+  +    F Q              ++ ++  E      R   
Sbjct: 1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKA--------EIERKLAEKDEEMEQAKRNHQ 1593

Query: 364  SPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLK 423
              +   Q   D++           +++     E+E Q     + + E +K ++ L   LK
Sbjct: 1594 RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1653

Query: 424  HTQIRMDREV----------------NQLKQWVTTMMMSITKEEDTA---AELEL----- 459
             TQI++D  V                N L Q     + ++ ++ + +   AE EL     
Sbjct: 1654 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1713

Query: 460  KARVFHFGEYKGDQQDKLLES----LNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLD 515
            + ++ H        Q K +ES    L  +V +  + C   +++A         + E +L 
Sbjct: 1714 RVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAE-ELK 1772

Query: 516  ELLENLEHVPQVKIEQAERAKEKERR------IRLREEKLQMQKILQEEHLQRARARAQA 569
            +  +   H+ ++K    +  K+ + R      I L+  K Q+QK+  E  ++      +A
Sbjct: 1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL--EARVRELEGELEA 1830

Query: 570  EIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKE 602
            E  +KR    V   R    RIK+ +  T  DK+
Sbjct: 1831 E--QKRNAESVKGMRKSERRIKELTYQTEEDKK 1861



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 50/212 (23%), Positives = 89/212 (41%), Gaps = 31/212 (14%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVN---QLKQWVTTMMMSITKEE 451
            +ELEE+ +SL+Q   + +  ++     L   + R D+ +    QL+  V  M   +  EE
Sbjct: 873  KELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEE 932

Query: 452  DTAAELELKARVF--HFGEYKGDQQD---------KLLESLNCKVLDVYRHCTG------ 494
            +  AEL  K R       E K D  D         K   +   KV ++     G      
Sbjct: 933  EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 992

Query: 495  --TQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQ----AERAKEKERRIRLREEK 548
              T+++  L       + + Q++E   N     +VK+EQ     E + E+E+++R+  E+
Sbjct: 993  KLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER 1052

Query: 549  LQMQ-----KILQEEHLQRARARAQAEIKKKR 575
             + +     K+ QE  +     + Q E K K+
Sbjct: 1053 AKRKLEGDLKLTQESIMDLENDKLQLEEKLKK 1084



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 49/202 (24%), Positives = 93/202 (46%), Gaps = 39/202 (19%)

Query: 392  DVFRELEEQNLSLIQNSQETEKTL---EELSHTLKHTQIRMDREVNQLKQWVTTMMMSIT 448
            ++  +L ++  +L +  Q+    L   E+  ++L  ++++++++V+ L+        S+ 
Sbjct: 989  EIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG-------SLE 1041

Query: 449  KEEDTAAELELKARVFHFGEYKGDQQD---------KLLESLNCKVLDVYRHCTGTQQEA 499
            +E+    +LE   R    G+ K  Q+          +L E L  K  D+       QQ +
Sbjct: 1042 QEKKVRMDLERAKRKLE-GDLKLTQESIMDLENDKLQLEEKLKKKEFDI------NQQNS 1094

Query: 500  NLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQ--MQKILQE 557
             +   Q+L +   QL + L+      Q +IE+ E   E ER  R + EKL+  + + L+E
Sbjct: 1095 KIEDEQVLAL---QLQKKLKE----NQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1147

Query: 558  --EHLQRA--RARAQAEIKKKR 575
              E L+ A      Q E+ KKR
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKR 1169


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 111/518 (21%), Positives = 215/518 (41%), Gaps = 65/518 (12%)

Query: 105  QLQLEDKQEDLEA----RAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFL 160
            Q ++E+ +E++EA    RA+AE QR+             + + E E +S  +++      
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRS-------------DLSRELEEISERLEEAGGATS 1162

Query: 161  LQYALDVKRR-EIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAE 219
             Q  ++ KR  E Q++     +   + E    +L K  A   + V E         R  +
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQ 1219

Query: 220  KETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH 279
            K  K K E  +EI DL + +  +       E   K  +  +D L ++  KE  EEQ++  
Sbjct: 1220 KLEKEKSEMKMEIDDLASNMETVSKAKGNLE---KMCRALEDQLSEIKTKE--EEQQRLI 1274

Query: 280  SFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSP 339
            + L   +  +    ES   S   D+   +  + S       Q  ++  R L+     +S 
Sbjct: 1275 NDLTAQR--ARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSA 1332

Query: 340  --SYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQL-YFTEPQQLLDVFRE 396
                L S +           + + + + +       +S+  + +  Y T+  Q  +   E
Sbjct: 1333 LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE---E 1389

Query: 397  LEEQNLSLIQNSQETEKTLEELSH---TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDT 453
            LEE    L Q  Q+ E+ +E ++    +L+ T+ R+  EV  L       M+ + +    
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL-------MIDVERTNAA 1442

Query: 454  AAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQ 513
             A L+ K R F          DK+L     K  + +     +Q+E+   + ++  I ++ 
Sbjct: 1443 CAALDKKQRNF----------DKILAEWKQKCEETHAELEASQKESRSLSTELFKI-KNA 1491

Query: 514  LDELLENLE-------HVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARAR 566
             +E L+ LE       ++ Q   +  E+  E  +RI    EK++ Q   ++  LQ A   
Sbjct: 1492 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH-ELEKIKKQVEQEKSELQAALEE 1550

Query: 567  AQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
            A+A ++ + G+ L  R +   +++K + +  + +K+EE
Sbjct: 1551 AEASLEHEEGKIL--RIQLELNQVKSEVDRKIAEKDEE 1586



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 107/594 (18%), Positives = 232/594 (39%), Gaps = 98/594 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSL-----RRQLQLEDKQEDLEARAEA-- 121
            +R + L E +++   R+     +   V+AK  SL     R Q ++ED   D+E    A  
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444

Query: 122  ---EHQRAF-RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLET 177
               + QR F +    WK    +E + E E       QK    L      +K    + L+ 
Sbjct: 1445 ALDKKQRNFDKILAEWKQKC-EETHAELE-----ASQKESRSLSTELFKIKNAYEESLDQ 1498

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVREND--CSSVQAMRAAEKETKAKIEKILEIRDL 235
            L T     L+R  K+L+++ +   E + E       ++ ++   ++ K++++  LE  + 
Sbjct: 1499 LET-----LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEA 1553

Query: 236  TTQ-----IVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE 290
            + +     I+ I+ E+++ +  +      KD        E +++ ++ H  + ++ + + 
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEVDRKIAEKD--------EEIDQMKRNHIRIVESMQSTL 1605

Query: 291  ASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ 350
             ++  S N     K   ++G  + M  +     +     L+  R   + + L   Q    
Sbjct: 1606 DAEIRSRNDAIRLKKK-MEGDLNEMEIQLNHANRMAAEALRNYR--NTQAILKDTQLHLD 1662

Query: 351  PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP--------QQLLDVFRE---LEE 399
             +  S  D +   + +        ++ EE +    +         Q+LLD       L  
Sbjct: 1663 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722

Query: 400  QNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM---SITKEEDTAAE 456
            QN SLI   ++ E  + ++   ++           + K+ +T   M    + KE+DT+A 
Sbjct: 1723 QNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1782

Query: 457  LELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDE 516
            LE                 ++ ++L   V D+       +Q A  G  + +  +E ++ E
Sbjct: 1783 LE-----------------RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE 1825

Query: 517  LLENLEHVPQVKIEQAERAKEKERRIR--------------------------LREEKLQ 550
            L   +E   +  +E  +  ++ ER+++                          ++  K Q
Sbjct: 1826 LEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ 1885

Query: 551  MQKILQEEHLQRAR-ARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEE 603
             ++  ++ ++  ++  R Q E+++   R  +  S+    R+K +  HT +  EE
Sbjct: 1886 AEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 59/227 (25%), Positives = 104/227 (45%), Gaps = 28/227 (12%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVN---QLKQWVTTMMMSITKEE 451
            +ELEE+ ++L+Q   + +  ++  + +L   + R D+ +    QL+  +  +      EE
Sbjct: 875  KELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934

Query: 452  DTAAELELKARVF--HFGEYKGDQQDKLLESLNCKVLDVYRHCTG------TQQEANLG- 502
            +  AEL  K R       E K D  D  LE    KV +  +H T       T++ A L  
Sbjct: 935  EINAELTAKKRKLEDECSELKKDIDD--LELTLAKV-EKEKHATENKVKNLTEEMAGLDE 991

Query: 503  TVQMLTIIEHQLDE----LLENLEHVPQVKIEQAERAKEK-ERRIRLREEKLQMQKILQE 557
            T+  LT  +  L E     L++L+   + K+    +AK K E+++   E  L+ +K ++ 
Sbjct: 992  TIAKLTKEKKALQEAHQQTLDDLQ-AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRM 1050

Query: 558  EHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
            + L+RA+ + + ++K      L   S       KQQ +  L  KE E
Sbjct: 1051 D-LERAKRKLEGDLK------LAQESTMDIENDKQQLDEKLKKKEFE 1090



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 106/523 (20%), Positives = 203/523 (38%), Gaps = 73/523 (13%)

Query: 79   QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQ--EDLEARAEAEHQRAFRDYTTWKLT 136
            + K   + ++M    +  AK T  ++ LQ   +Q  +DL+A  +  +            T
Sbjct: 976  ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN------------T 1023

Query: 137  LTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKS---L 193
            LTK K          IK ++Q+  L+ +L+ +++    LE    K E  L+ A++S   +
Sbjct: 1024 LTKAK----------IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDI 1073

Query: 194  EKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEI-SRFEDT 252
            E D    DE +++ +          E E    ++   +I++L  +I  ++ EI +     
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASR 1133

Query: 253  LKHYKVYKDFLYKLSP-KEWLEE------------QEKKHSFLKKAKEVSEASKESSVNS 299
             K  K   D   +L    E LEE            ++++  F K  +++ EA+ +    +
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193

Query: 300  TPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDS 359
                    ++ K +   A+ G+      R  Q +   +S   +      S     S   +
Sbjct: 1194 AT------LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS--KA 1245

Query: 360  RGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELS 419
            +G+   +    ED  S+ +  +    E QQ L    +L  Q   L   S E  + L+E  
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKE----EEQQRL--INDLTAQRARLQTESGEYSRQLDE-- 1297

Query: 420  HTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLE 479
               K T +    ++++ KQ  T  +  + ++ +   E++ K+ + H  +      D L E
Sbjct: 1298 ---KDTLV---SQLSRGKQAFTQQIEELKRQLE--EEIKAKSALAHALQSSRHDCDLLRE 1349

Query: 480  SLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKE 539
                +  +          +AN    Q  T  E    +  E LE   +   ++ + A+E  
Sbjct: 1350 QYE-EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408

Query: 540  RRIRLREEKLQMQK-ILQEE------HLQRARARAQAEIKKKR 575
              +  +   L+  K  LQ E       ++R  A   A  KK+R
Sbjct: 1409 EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 56/257 (21%), Positives = 109/257 (42%), Gaps = 46/257 (17%)

Query: 65   LRDQERNKALSERQ----QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDL--EAR 118
            L   ER++ ++E++     ++   +H + T  S ++ K        Q++ + ED+  EAR
Sbjct: 1696 LEQTERSRKIAEQELLDASERVQLLHTQNT--SLINTKKKLETDISQIQGEMEDIIQEAR 1753

Query: 119  -AEAEHQRAFRDYTTWKLTLTKEKNVEP------ENMSGYIK--QKRQMFLLQYALDVKR 169
             AE + ++A  D       L KE++         +N+   +K  Q R     Q AL   +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813

Query: 170  REIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKI 229
            ++IQ+LE    + E  +E  +K                   +V+A++   K  +      
Sbjct: 1814 KQIQKLEARVRELEGEVESEQK------------------RNVEAVKGLRKHER------ 1849

Query: 230  LEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH--SFLKKAKE 287
             ++++LT Q    +  I R +D +   +  K   YK   +E  EEQ   +   F +   E
Sbjct: 1850 -KVKELTYQTEEDRKNILRLQDLVDKLQA-KVKSYKRQAEE-AEEQSNVNLSKFRRIQHE 1906

Query: 288  VSEASKESSVNSTPGDK 304
            + EA + + +  +  +K
Sbjct: 1907 LEEAEERADIAESQVNK 1923


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 106/554 (19%), Positives = 218/554 (39%), Gaps = 45/554 (8%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQ 124
            ++  E  KAL  +  ++T++V Q    S+    K   +    QLE  +E  E + + + +
Sbjct: 824  MKKDEALKALQNQVSEETIKVRQ--LDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSE 881

Query: 125  RAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEA 184
              +         L KE  ++  ++    +   Q  +LQ+ L  +++ +Q+ ET+   E  
Sbjct: 882  EVY--------CLQKELKIKNHSLQ---ETSEQNVILQHTLQQQQQMLQQ-ETIRNGE-- 927

Query: 185  RLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEK-------ETKAKIEKILEI----R 233
             LE  +  LEK  +  ++ +++   SS + +R  E+       E   K +K++E+    R
Sbjct: 928  -LEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTAR 986

Query: 234  DLTTQIVNIKSEISRFEDTLKHYK-VYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEAS 292
             +  ++   K E+S+ E  + H K   ++    LS  + + +Q K     KK   V E  
Sbjct: 987  QVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKT-ELEKKTNAVKELE 1045

Query: 293  KESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPS 352
            K      T   +    +    +         K   R LQ +R     + LS  ++ +   
Sbjct: 1046 KLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIK 1105

Query: 353  ESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFR----------ELEEQNL 402
            + +              QE  + D    +  +   Q+   V            E+E++ +
Sbjct: 1106 DLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKII 1165

Query: 403  SLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKAR 462
             L    +++E  L+E +  ++    ++     QL++    M+ +  +      E+E   +
Sbjct: 1166 KLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ 1225

Query: 463  VFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLE 522
                 E    +Q++ + +   + +D+ +    T+++      + L    HQ  +    +E
Sbjct: 1226 RMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTE-LAEARHQQVQAQREIE 1284

Query: 523  HVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCR 582
             +     +  + +KEK+       E+L   K+ +E HL+   AR QAEIKK        +
Sbjct: 1285 RLSSELEDMKQLSKEKDAHGNHLAEELGASKV-REAHLE---ARMQAEIKKLSAEVESLK 1340

Query: 583  SRPPAHRIKQQSEH 596
                   I  Q  H
Sbjct: 1341 EAYHMEMISHQENH 1354



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 100/497 (20%), Positives = 199/497 (40%), Gaps = 100/497 (20%)

Query: 84   RVHQKMTYSSKVSAKHTSLRRQL-QLEDKQEDLEARAEAEHQR---AFRDYTTWKLTLTK 139
            ++ +K+   S ++AK+  L ++L +  +K   LE     EH++   AF       L   K
Sbjct: 705  QLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHK 764

Query: 140  EKNVEPENMSGYIKQKRQMF--------LLQYALDVKRREIQRLETLATKEEARLERAEK 191
            E   + E +   +++K Q F        +LQ  +  K+  ++ L+ L T  E++ E  ++
Sbjct: 765  EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLT--ESKGEMKKE 822

Query: 192  SLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFED 251
            +++KD                +A++A + +     E+ +++R L + +   K E+    +
Sbjct: 823  NMKKD----------------EALKALQNQVS---EETIKVRQLDSALEICKEELVLHLN 863

Query: 252  TLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGK 311
             L+              KE  E+Q KK     K++EV    KE             +K K
Sbjct: 864  QLE------------GNKEKFEKQLKK-----KSEEVYCLQKE-------------LKIK 893

Query: 312  ASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQE 371
              S+     Q T +    LQ          L   QQ  Q      G+   + + +     
Sbjct: 894  NHSL-----QETSEQNVILQHT--------LQQQQQMLQQETIRNGELEDTQTKLEKQVS 940

Query: 372  DTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDR 431
              + + ++ +      +   +  R++EE+  S    +    + + EL+ T +  +I MD+
Sbjct: 941  KLEQELQKQR------ESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994

Query: 432  EVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLN--CKVLDVY 489
               +L +    +M      E+ A  L     +        DQ    LE      K L+  
Sbjct: 995  YKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL-------DQTKTELEKKTNAVKELEKL 1047

Query: 490  RHCTGTQQEANLGTVQML-TIIEHQLDELLENLEHVPQVK--IEQAERAKE------KER 540
            +H T T+    L   ++L T +++   EL   L  + +++  +++A+ + E      K+ 
Sbjct: 1048 QHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDL 1107

Query: 541  RIRLREEKLQMQKILQE 557
               LRE K++++   QE
Sbjct: 1108 TAELRECKMEIEDKKQE 1124



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 52/234 (22%), Positives = 102/234 (43%), Gaps = 39/234 (16%)

Query: 394 FRELEEQNLSLIQNS--------QETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM 445
           F+E +E+ +S++Q          +  ++ L E    +K   ++ D  +  L+  V+   +
Sbjct: 784 FKE-QEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETI 842

Query: 446 SITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQ 505
            + ++ D+A E+  +  V H  + +G+++ K  + L  K  +VY  C   Q+E       
Sbjct: 843 KV-RQLDSALEICKEELVLHLNQLEGNKE-KFEKQLKKKSEEVY--CL--QKE------- 889

Query: 506 MLTIIEHQLDELLEN---LEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQR 562
            L I  H L E  E    L+H  Q + +  ++   +   +   + KL+ Q    E+ LQ+
Sbjct: 890 -LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948

Query: 563 ARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTL----------MDKEEEEL 606
            R  +  +++K   +   C S      +K+Q    L          MD+ +EEL
Sbjct: 949 QRESSAEKLRKMEEK---CESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 102/500 (20%), Positives = 197/500 (39%), Gaps = 72/500 (14%)

Query: 109  EDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKR---QMFLLQYAL 165
            +  Q  +  + E E QR        +   TK   +E EN    +       Q  L+Q  L
Sbjct: 622  DQNQHTMNKQYEKERQRLVTGIEELR---TKLIQIEAENSDLKVNMAHRTSQFQLIQEEL 678

Query: 166  DVKRREIQRLETLATKEEARLERAEKSLE-----------KDAALFDEFVREND-CSSVQ 213
              K     +LE+  TK+ ++L   EK LE           K+A L  E + +N+   S++
Sbjct: 679  LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLE 738

Query: 214  AMRAAEKE------TKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYK-----VYKDF 262
                 E E       KAK   + + +++  QI  +++++ + +   K  +     + +D 
Sbjct: 739  TNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDI 798

Query: 263  LYKLSPKEWLEE--QEKKHSFLKKAKEVSEASK-------ESSVNSTPGDKGPGIKGKAS 313
            + K    E L+    E K    K+  +  EA K       E ++     D    I  +  
Sbjct: 799  ICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL 858

Query: 314  SMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPT---- 369
             +   + +G K+ +      +L +    +   Q+  +    S  ++   N  +  T    
Sbjct: 859  VLHLNQLEGNKEKFE----KQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ 914

Query: 370  ----QEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTL--- 422
                Q++T  +GE         +Q+  + +EL++Q  S  +  ++ E+  E  +H     
Sbjct: 915  QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK 974

Query: 423  KHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLN 482
            +   I +     Q+K     + M   KEE +  E E+          K D ++K   +++
Sbjct: 975  RQKVIELTGTARQVK-----IEMDQYKEELSKMEKEIM-------HLKRDGENK---AMH 1019

Query: 483  CKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLD-ELLENLE--HVPQVKIEQAE-RAKEK 538
               LD+    T T+ E     V+ L  ++H  + EL E L+   V + +++ A    K  
Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 1079

Query: 539  ERRIRLREEKLQMQKILQEE 558
             R+++   + LQ  ++  EE
Sbjct: 1080 LRQLQELRDVLQKAQLSLEE 1099


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 121/561 (21%), Positives = 229/561 (40%), Gaps = 72/561 (12%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRR-----QLQLEDKQEDLEA----R 118
            +   + L E+ ++K   +    +      A    L++     Q ++E+ +E++EA    R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 119  AEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRR-EIQRLET 177
            A+AE QR+             + + E E +S  +++       Q  ++ KR  E Q++  
Sbjct: 1136 AKAEKQRS-------------DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
               +   + E    +L K  A   + V E         R  +K  K K E  +EI DL +
Sbjct: 1183 DLEEATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

Query: 238  QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSV 297
             +  +       E   K  +  +D L +L  KE  EEQ++  + L   +       ES  
Sbjct: 1240 NVETVSKAKGNLE---KMCRTLEDQLSELKSKE--EEQQRLINDLTAQR--GRLQTESGE 1292

Query: 298  NSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSP--SYLSSPQQGSQPSESS 355
             S   D+   +  + S       Q  ++  R L+     ++     L S +         
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352

Query: 356  GGDSRGSNSPIPPTQEDTDSDGEEPQL-YFTEPQQLLDVFRELEEQNLSLIQNSQETEKT 414
              + + S + +       +++  + +  Y T+  Q  +   ELEE    L Q  Q  E+ 
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE---ELEEAKKKLAQRLQAAEEH 1409

Query: 415  LEELSH---TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKG 471
            +E ++    +L+ T+ R+  EV  L       M+ + +     A L+ K R F       
Sbjct: 1410 VEAVNAKCASLEKTKQRLQNEVEDL-------MLDVERTNAACAALDKKQRNF------- 1455

Query: 472  DQQDKLLESLNCKVLDVYRHCTGTQQEA-NLGTVQMLTIIEHQLDELLENLE-------H 523
               DK+L     K  + +     +Q+EA +LGT   L  I++  +E L+ LE       +
Sbjct: 1456 ---DKILAEWKQKCEETHAELEASQKEARSLGTE--LFKIKNAYEESLDQLETLKRENKN 1510

Query: 524  VPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRS 583
            + Q   +  E+  E  +RI    EK++ Q   ++  LQ A   A+A ++ + G+ L  R 
Sbjct: 1511 LQQEISDLTEQIAEGGKRIH-ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL--RI 1567

Query: 584  RPPAHRIKQQSEHTLMDKEEE 604
            +   +++K + +  + +K+EE
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEE 1588



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 47/196 (23%), Positives = 94/196 (47%), Gaps = 27/196 (13%)

Query: 392  DVFRELEEQNLSLIQNSQETEKTL---EELSHTLKHTQIRMDREVNQLKQWVTTMMMSIT 448
            +   +L ++  +L +  Q+T   L   E+  +TL   +I+++++V+ L+        S+ 
Sbjct: 993  ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEG-------SLE 1045

Query: 449  KEEDTAAELELKARVFHFGEYK---------GDQQDKLLESLNCKVLDVYRHCTGTQQEA 499
            +E+    +LE   R    G+ K          +++ +L E L  K  ++    +  + E 
Sbjct: 1046 QEKKLRMDLERAKRKLE-GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104

Query: 500  NLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEH 559
             LG +Q+   I+ +L   +E LE   +++ E+A RAK +++R  L  E  ++ + L+E  
Sbjct: 1105 ALG-IQLQKKIK-ELQARIEELEE--EIEAERASRAKAEKQRSDLSRELEEISERLEE-- 1158

Query: 560  LQRARARAQAEIKKKR 575
                   AQ E+ KKR
Sbjct: 1159 -AGGATSAQIEMNKKR 1173



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 117/590 (19%), Positives = 224/590 (37%), Gaps = 90/590 (15%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSL-----RRQLQLEDKQEDLEARAEA-- 121
            +R + L E +++   R+     +   V+AK  SL     R Q ++ED   D+E    A  
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446

Query: 122  ---EHQRAF-RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLET 177
               + QR F +    WK    +E + E E       QK    L      +K    + L+ 
Sbjct: 1447 ALDKKQRNFDKILAEWKQKC-EETHAELE-----ASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
            L T     L+R  K+L+++ +   E + E      +  +  ++  + K E    + +   
Sbjct: 1501 LET-----LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555

Query: 238  QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPK-EWLEEQEKKHSFLKKAKEVSEASKESS 296
             + + + +I R +  L   K   D   K++ K E +++ ++ H  + ++ + +  ++  S
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 297  VNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSG 356
             N     K   ++G  + M  +     +     L+  R   +   L   Q     +  S 
Sbjct: 1614 RNDAIRLKKK-MEGDLNEMEIQLNHANRMAAEALRNYR--NTQGILKDTQIHLDDALRSQ 1670

Query: 357  GDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP--------QQLLDVFRE---LEEQNLSLI 405
             D +   + +        ++ EE +    +         Q+LLD       L  QN SLI
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 406  QNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM---SITKEEDTAAELE---- 458
               ++ E  + ++   ++           + K+ +T   M    + KE+DT+A LE    
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790

Query: 459  --------LKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTII 510
                    L+ R+    +       K ++ L  +V ++      ++Q+ N   V+ L   
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE-SEQKRNAEAVKGLRKH 1849

Query: 511  EHQLDEL-------------LENLEHVPQVKIE----QAERAKEKERRIRLREEKLQMQK 553
            E ++ EL             L++L    Q K++    QAE A+E+      +  KLQ   
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ--- 1906

Query: 554  ILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEE 603
                  L+ A  RA            +  S+    R+K +  HT +  EE
Sbjct: 1907 ----HELEEAEERAD-----------IAESQVNKLRVKSREVHTKVISEE 1941



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 59/257 (22%), Positives = 111/257 (43%), Gaps = 46/257 (17%)

Query: 65   LRDQERNKALSERQ----QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDL--EAR 118
            L   ER++ ++E++     ++   +H + T  S ++ K        Q++ + ED+  EAR
Sbjct: 1698 LEQTERSRKIAEQELLDASERVQLLHTQNT--SLINTKKKLETDISQMQGEMEDILQEAR 1755

Query: 119  -AEAEHQRAFRDYTTWKLTLTKEKNVEP------ENMSGYIK--QKRQMFLLQYALDVKR 169
             AE + ++A  D       L KE++         +NM   +K  Q R     Q AL   +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK 1815

Query: 170  REIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKI 229
            ++IQ+L       EAR+   E  +E +        ++ +  +V+ +R  E+         
Sbjct: 1816 KQIQKL-------EARVRELEGEVESE--------QKRNAEAVKGLRKHER--------- 1851

Query: 230  LEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH--SFLKKAKE 287
              +++LT Q    +  I R +D +   +  K   YK   +E  EEQ   +   F K   E
Sbjct: 1852 -RVKELTYQTEEDRKNILRLQDLVDKLQA-KVKSYKRQAEE-AEEQSNTNLAKFRKLQHE 1908

Query: 288  VSEASKESSVNSTPGDK 304
            + EA + + +  +  +K
Sbjct: 1909 LEEAEERADIAESQVNK 1925



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 43/208 (20%), Positives = 98/208 (47%), Gaps = 23/208 (11%)

Query: 405  IQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITK--EEDTAAELELKAR 462
            I+   E  +  EE++  L   + +++ E ++LK+ +  + +++ K  +E  A E ++K  
Sbjct: 925  IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984

Query: 463  VFHFGEY-----KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTI-IEHQLDE 516
                        K  ++ K L+  + + LD  +      +E  + T+    I +E Q+D+
Sbjct: 985  TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-----AEEDKVNTLTKAKIKLEQQVDD 1039

Query: 517  LLENLEHVPQVKIEQAERAKEK---------ERRIRLREEKLQMQKILQEEHLQRARARA 567
            L  +LE   +++++  ERAK K         E  + +  EK Q+ + L+++  + +  ++
Sbjct: 1040 LEGSLEQEKKLRMD-LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098

Query: 568  QAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
            + E ++  G  L  + +    RI++  E
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEE 1126


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 121/561 (21%), Positives = 229/561 (40%), Gaps = 72/561 (12%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRR-----QLQLEDKQEDLEA----R 118
            +   + L E+ ++K   +    +      A    L++     Q ++E+ +E++EA    R
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 119  AEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRR-EIQRLET 177
            A+AE QR+             + + E E +S  +++       Q  ++ KR  E Q++  
Sbjct: 1136 AKAEKQRS-------------DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
               +   + E    +L K  A   + V E         R  +K  K K E  +EI DL +
Sbjct: 1183 DLEEATLQHEATAATLRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239

Query: 238  QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSV 297
             +  +       E   K  +  +D L +L  KE  EEQ++  + L   +       ES  
Sbjct: 1240 NVETVSKAKGNLE---KMCRTLEDQLSELKSKE--EEQQRLINDLTAQR--GRLQTESGE 1292

Query: 298  NSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSP--SYLSSPQQGSQPSESS 355
             S   D+   +  + S       Q  ++  R L+     ++     L S +         
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352

Query: 356  GGDSRGSNSPIPPTQEDTDSDGEEPQL-YFTEPQQLLDVFRELEEQNLSLIQNSQETEKT 414
              + + S + +       +++  + +  Y T+  Q  +   ELEE    L Q  Q  E+ 
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE---ELEEAKKKLAQRLQAAEEH 1409

Query: 415  LEELSH---TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKG 471
            +E ++    +L+ T+ R+  EV  L       M+ + +     A L+ K R F       
Sbjct: 1410 VEAVNAKCASLEKTKQRLQNEVEDL-------MLDVERTNAACAALDKKQRNF------- 1455

Query: 472  DQQDKLLESLNCKVLDVYRHCTGTQQEA-NLGTVQMLTIIEHQLDELLENLE-------H 523
               DK+L     K  + +     +Q+EA +LGT   L  I++  +E L+ LE       +
Sbjct: 1456 ---DKILAEWKQKCEETHAELEASQKEARSLGTE--LFKIKNAYEESLDQLETLKRENKN 1510

Query: 524  VPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRS 583
            + Q   +  E+  E  +RI    EK++ Q   ++  LQ A   A+A ++ + G+ L  R 
Sbjct: 1511 LQQEISDLTEQIAEGGKRIH-ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL--RI 1567

Query: 584  RPPAHRIKQQSEHTLMDKEEE 604
            +   +++K + +  + +K+EE
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEE 1588



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 47/196 (23%), Positives = 94/196 (47%), Gaps = 27/196 (13%)

Query: 392  DVFRELEEQNLSLIQNSQETEKTL---EELSHTLKHTQIRMDREVNQLKQWVTTMMMSIT 448
            +   +L ++  +L +  Q+T   L   E+  +TL   +I+++++V+ L+        S+ 
Sbjct: 993  ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEG-------SLE 1045

Query: 449  KEEDTAAELELKARVFHFGEYK---------GDQQDKLLESLNCKVLDVYRHCTGTQQEA 499
            +E+    +LE   R    G+ K          +++ +L E L  K  ++    +  + E 
Sbjct: 1046 QEKKLRMDLERAKRKLE-GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104

Query: 500  NLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEH 559
             LG +Q+   I+ +L   +E LE   +++ E+A RAK +++R  L  E  ++ + L+E  
Sbjct: 1105 ALG-IQLQKKIK-ELQARIEELEE--EIEAERASRAKAEKQRSDLSRELEEISERLEE-- 1158

Query: 560  LQRARARAQAEIKKKR 575
                   AQ E+ KKR
Sbjct: 1159 -AGGATSAQIEMNKKR 1173



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 117/590 (19%), Positives = 224/590 (37%), Gaps = 90/590 (15%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSL-----RRQLQLEDKQEDLEARAEA-- 121
            +R + L E +++   R+     +   V+AK  SL     R Q ++ED   D+E    A  
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446

Query: 122  ---EHQRAF-RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLET 177
               + QR F +    WK    +E + E E       QK    L      +K    + L+ 
Sbjct: 1447 ALDKKQRNFDKILAEWKQKC-EETHAELE-----ASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
            L T     L+R  K+L+++ +   E + E      +  +  ++  + K E    + +   
Sbjct: 1501 LET-----LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEA 1555

Query: 238  QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPK-EWLEEQEKKHSFLKKAKEVSEASKESS 296
             + + + +I R +  L   K   D   K++ K E +++ ++ H  + ++ + +  ++  S
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVD--RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 297  VNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSG 356
             N     K   ++G  + M  +     +     L+  R   +   L   Q     +  S 
Sbjct: 1614 RNDAIRLKKK-MEGDLNEMEIQLNHANRMAAEALRNYR--NTQGILKDTQIHLDDALRSQ 1670

Query: 357  GDSRGSNSPIPPTQEDTDSDGEEPQLYFTEP--------QQLLDVFRE---LEEQNLSLI 405
             D +   + +        ++ EE +    +         Q+LLD       L  QN SLI
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 406  QNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM---SITKEEDTAAELE---- 458
               ++ E  + ++   ++           + K+ +T   M    + KE+DT+A LE    
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790

Query: 459  --------LKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTII 510
                    L+ R+    +       K ++ L  +V ++      ++Q+ N   V+ L   
Sbjct: 1791 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVE-SEQKRNAEAVKGLRKH 1849

Query: 511  EHQLDEL-------------LENLEHVPQVKIE----QAERAKEKERRIRLREEKLQMQK 553
            E ++ EL             L++L    Q K++    QAE A+E+      +  KLQ   
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQ--- 1906

Query: 554  ILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEE 603
                  L+ A  RA            +  S+    R+K +  HT +  EE
Sbjct: 1907 ----HELEEAEERAD-----------IAESQVNKLRVKSREVHTKVISEE 1941



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 59/257 (22%), Positives = 111/257 (43%), Gaps = 46/257 (17%)

Query: 65   LRDQERNKALSERQ----QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDL--EAR 118
            L   ER++ ++E++     ++   +H + T  S ++ K        Q++ + ED+  EAR
Sbjct: 1698 LEQTERSRKIAEQELLDASERVQLLHTQNT--SLINTKKKLETDISQMQGEMEDILQEAR 1755

Query: 119  -AEAEHQRAFRDYTTWKLTLTKEKNVEP------ENMSGYIK--QKRQMFLLQYALDVKR 169
             AE + ++A  D       L KE++         +NM   +K  Q R     Q AL   +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK 1815

Query: 170  REIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKI 229
            ++IQ+L       EAR+   E  +E +        ++ +  +V+ +R  E+         
Sbjct: 1816 KQIQKL-------EARVRELEGEVESE--------QKRNAEAVKGLRKHER--------- 1851

Query: 230  LEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH--SFLKKAKE 287
              +++LT Q    +  I R +D +   +  K   YK   +E  EEQ   +   F K   E
Sbjct: 1852 -RVKELTYQTEEDRKNILRLQDLVDKLQA-KVKSYKRQAEE-AEEQSNTNLAKFRKLQHE 1908

Query: 288  VSEASKESSVNSTPGDK 304
            + EA + + +  +  +K
Sbjct: 1909 LEEAEERADIAESQVNK 1925



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 43/208 (20%), Positives = 98/208 (47%), Gaps = 23/208 (11%)

Query: 405  IQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITK--EEDTAAELELKAR 462
            I+   E  +  EE++  L   + +++ E ++LK+ +  + +++ K  +E  A E ++K  
Sbjct: 925  IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984

Query: 463  VFHFGEY-----KGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTI-IEHQLDE 516
                        K  ++ K L+  + + LD  +      +E  + T+    I +E Q+D+
Sbjct: 985  TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-----AEEDKVNTLTKAKIKLEQQVDD 1039

Query: 517  LLENLEHVPQVKIEQAERAKEK---------ERRIRLREEKLQMQKILQEEHLQRARARA 567
            L  +LE   +++++  ERAK K         E  + +  EK Q+ + L+++  + +  ++
Sbjct: 1040 LEGSLEQEKKLRMD-LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098

Query: 568  QAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
            + E ++  G  L  + +    RI++  E
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEE 1126


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 105/524 (20%), Positives = 209/524 (39%), Gaps = 98/524 (18%)

Query: 65  LRDQE---RNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEA 121
           LR+QE   R +    R+Q+K +R  +K     ++  +   LR Q +L +++E ++ + E 
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEK-----ELREQEKELREQKKLREQEEQMQEQEEK 318

Query: 122 --EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLA 179
             E +   R+    K+   +E+  E E      +QK +        D + R  ++ E L 
Sbjct: 319 MWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQKMR--------DQEERMWEQDERLR 369

Query: 180 TKEEARLERAEKSLEKDAALFDEF-VRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQ 238
            KEE R+   EK  E++  + +E  +RE +    + MR  E+  + + EK+         
Sbjct: 370 EKEE-RMREQEKMWEQEEKMQEEERIRERE----KKMREEEETMREQEEKMQ-------- 416

Query: 239 IVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVN 298
               K E + +E   K ++  +        KE L EQEK     +K  E  E  ++    
Sbjct: 417 ----KQEENMWEQEEKEWQQQR----LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE- 467

Query: 299 STPGDKGPGIKGKASSMWAKEGQGTKKP--WRFLQTMRLGRSPSYLSSPQQGSQPSESSG 356
                    + G+   MW +E    ++   W   + MR      +    +   Q      
Sbjct: 468 ---------MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518

Query: 357 GDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLE 416
            + R         QE+   + ++ Q    + ++  D   ++ E+     +  +E EK + 
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQ---EQEKKTWDQEEKMREE-----ERMREREKKMR 570

Query: 417 ELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDK 476
           E    ++  + +M  +  ++++    M     ++E+   E E K        ++ +++DK
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMW----EQEEKMQEQEEKMWEQEEKMWEQEEEDK 626

Query: 477 LLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAK 536
           + E                               E  + E  E ++   +   EQ E+ +
Sbjct: 627 MQEQ------------------------------EEMMWEQEEKMQEQEEKMWEQEEKMR 656

Query: 537 EKERRIRLREEKLQMQKIL---QEEHLQRARARAQAEIKKKRGR 577
           E+E ++R +EEK+Q Q+     QEE +Q    + + + +K RG+
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQ 700



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 95/491 (19%), Positives = 192/491 (39%), Gaps = 55/491 (11%)

Query: 122 EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
           E QRA    +TW     +      +       +  +  +    L  K  E+Q    LA  
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAES 201

Query: 182 EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
           E++ ++   K L++        + +   +++Q     ++E         E+R+   +I  
Sbjct: 202 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE---------ELREQEKKIRK 252

Query: 242 IKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTP 301
            + ++ R E+ L+  +           +E +  QEK+    ++ KE+ E  KE       
Sbjct: 253 QEEKMWRQEERLREQEGKMR-----EQEEKMRRQEKR--LREQEKELREQEKELREQKKL 305

Query: 302 GDKGPGIKGKASSMWAKEG---QGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGD 358
            ++   ++ +   MW +E    +  +K WR  Q  RL      +   +Q  +  E     
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWR--QEERLWEQEKQMREQEQKMRDQEER--- 360

Query: 359 SRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEEL 418
                        + D    E +    E +++ +   +++E+     +  +E EK + E 
Sbjct: 361 -----------MWEQDERLREKEERMREQEKMWEQEEKMQEE-----ERIREREKKMREE 404

Query: 419 SHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLL 478
             T++  + +M ++          M     KE       E K +++   E   +Q++K+ 
Sbjct: 405 EETMREQEEKMQKQEEN-------MWEQEEKEWQQQRLPEQKEKLWE-QEKMQEQEEKIW 456

Query: 479 ESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEK 538
           E    K+ D      G  QE  +   + +   E Q+ E  E +    Q   +Q ER  E+
Sbjct: 457 EQEE-KIRD-QEEMWG--QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512

Query: 539 ERRIRLREEKLQMQ-KILQEEHLQRARARAQAEIKKKRGRTLVCR--SRPPAHRIKQQSE 595
           + R+R +EE+++ Q K+ Q+E   R   + Q + KK   +    R   R      K + E
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572

Query: 596 HTLMDKEEEEL 606
             +M ++EE++
Sbjct: 573 EEMMREQEEKM 583



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 76/533 (14%), Positives = 216/533 (40%), Gaps = 85/533 (15%)

Query: 74  LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTW 133
           L++ +   ++ +++    + ++  K+  L+ +L+L          AE+E      +    
Sbjct: 164 LTKERDALSLELYRNTITNEELKKKNAELQEKLRL----------AESEKSEIQLNVKEL 213

Query: 134 KLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSL 193
           K  L + K + P+  +  +++  +M+  +  L  + ++I++ E    ++E RL   E  +
Sbjct: 214 KRKLERAKFLLPQVQTNTLQE--EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271

Query: 194 EKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTL 253
            +     +E +R  +    + +R  EKE + + +++ E + L  Q   ++ +  +  +  
Sbjct: 272 REQ----EEKMRRQE----KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 254 KHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKAS 313
           +  +  ++ +++   + W +E++ +    K                        ++ +  
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQK------------------------MRDQEE 359

Query: 314 SMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDT 373
            MW ++ +  +K  R  +  ++      +   ++  +  +    +           Q+  
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419

Query: 374 DSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREV 433
           ++  E+ +  + + Q+L +   +L EQ     +  QE E+ + E    ++  +    +E 
Sbjct: 420 ENMWEQEEKEWQQ-QRLPEQKEKLWEQ-----EKMQEQEEKIWEQEEKIRDQEEMWGQEK 473

Query: 434 NQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCT 493
              +Q        + ++ED   E E K R         DQ+ K+ +              
Sbjct: 474 KMWRQ------EKMREQEDQMWEQEEKMR---------DQEQKMWD-------------- 504

Query: 494 GTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQK 553
             Q+E      + L   E ++ E  +  +   + K+ + ++ +E+E++   +EEK++ ++
Sbjct: 505 --QEERMWEQDERLREKEERMREQKKMWQQ--EEKMREEKKTQEQEKKTWDQEEKMREEE 560

Query: 554 ILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
            ++E   +          ++++ +    + R    ++ +Q E   M ++EE++
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK--MQEQEEKM 611


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 109/527 (20%), Positives = 212/527 (40%), Gaps = 83/527 (15%)

Query: 105  QLQLEDKQEDLEA----RAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFL 160
            Q ++E+ +E++EA    RA+AE QR+             + + E E +S  +++      
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRS-------------DLSRELEEISERLEEAGGATS 1162

Query: 161  LQYALDVKRR-EIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAE 219
             Q  ++ KR  E Q++     +   + E    +L K  A   + V E         R  +
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHA---DSVAELGEQIDSLQRVKQ 1219

Query: 220  KETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH 279
            K  K K E  +EI DL + +  +    + FE   K  +  +D L ++  KE  EEQ++  
Sbjct: 1220 KLEKEKSELKMEINDLASNMETVSKAKANFE---KMCRTLEDQLSEIKTKE--EEQQRLI 1274

Query: 280  SFLKKAK--------EVSEASKESSVNSTPGDKGP-GIKGKASSMWAKEGQGTKKPWRFL 330
            + L   K        E S    E     +   +G      +   +  +  + TK      
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334

Query: 331  QTMRLGRSPSYLSSPQQGSQPSESSGGDSRG---SNSPIPPTQEDTDSDGEEPQLYFTEP 387
              ++  R    L   +Q  +  E+     RG   +NS +   +   ++D           
Sbjct: 1335 HALQSARHDCDLLR-EQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDA---------- 1383

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSH---TLKHTQIRMDREVNQLKQWVTTMM 444
               +    ELEE    L Q  Q+ E+ +E ++    +L+ T+ R+  EV  L       M
Sbjct: 1384 ---IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL-------M 1433

Query: 445  MSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTV 504
            + + +       L+ K R F          DK+L     K  +       +Q+E+   + 
Sbjct: 1434 IDVERSNAACIALDKKQRNF----------DKVLAEWKQKYEETQAELEASQKESRSLST 1483

Query: 505  QMLTIIEHQLDELLENLE-------HVPQVKIEQAERAKEKERRIRLREEKLQMQKILQE 557
            ++  + ++  +E L++LE       ++ Q   +  E+  E  + I    EK++ Q   ++
Sbjct: 1484 ELFKV-KNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIH-ELEKVKKQLDHEK 1541

Query: 558  EHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
              LQ +   A+A ++ + G+ L  R +   +++K + +  + +K+EE
Sbjct: 1542 SELQTSLEEAEASLEHEEGKIL--RIQLELNQVKSEIDRKIAEKDEE 1586



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 113/584 (19%), Positives = 224/584 (38%), Gaps = 83/584 (14%)

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEA-----E 122
            +E  K L++R Q      H +   S   S + T  R Q ++ED   D+E    A     +
Sbjct: 1391 EEAKKKLAQRLQDA--EEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK 1448

Query: 123  HQRAF-RDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATK 181
             QR F +    WK    +E   E E       QK    L      VK    + L+ L T 
Sbjct: 1449 KQRNFDKVLAEWKQKY-EETQAELE-----ASQKESRSLSTELFKVKNAYEESLDHLET- 1501

Query: 182  EEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVN 241
                L+R  K+L+++ +   E + E      +  +  ++    K E    + +    + +
Sbjct: 1502 ----LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEH 1557

Query: 242  IKSEISRFEDTLKHYKVYKDFLYKLSPK-EWLEEQEKKHSFLKKAKEVSEASKESSVNST 300
             + +I R +  L   K   D   K++ K E L++ ++ H  + ++ + +  ++  S N  
Sbjct: 1558 EEGKILRIQLELNQVKSEID--RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDA 1615

Query: 301  PGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSR 360
               K   ++G  + M  +     ++    L+ +R   +   L   Q     +     D +
Sbjct: 1616 LRIKKK-MEGDLNEMEIQLNHANRQAAEALRNLR--NTQGILKDTQLHLDDAIRGQDDLK 1672

Query: 361  GSNSPIPPTQEDTDSDGEE--PQLYFTE------PQQLLDVFRE---LEEQNLSLIQNSQ 409
               + +        ++ EE    L  TE       Q+LLD       L  QN SLI   +
Sbjct: 1673 EQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKK 1732

Query: 410  ETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM---SITKEEDTAAELELKARVFHF 466
            + E  + ++   ++           + K+ +T   M    + KE+DT+A LE        
Sbjct: 1733 KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE-------- 1784

Query: 467  GEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQ 526
                     ++ +++   V D+       +Q A  G  + +  +E ++ EL   +E   +
Sbjct: 1785 ---------RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQK 1835

Query: 527  VKIEQAERAKEKERRIR--------------------------LREEKLQMQKILQEEHL 560
              +E  +  ++ ERR++                          ++  K Q ++  ++ ++
Sbjct: 1836 HNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNV 1895

Query: 561  QRARARA-QAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEE 603
              A+ R  Q E+++ + R  +  S+    R+K +  HT +  EE
Sbjct: 1896 NLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 60/227 (26%), Positives = 102/227 (44%), Gaps = 28/227 (12%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVN---QLKQWVTTMMMSITKEE 451
            +ELEE+ ++L+Q   + +  ++  +  L   + R D+ +    QL+  +  +      EE
Sbjct: 875  KELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934

Query: 452  DTAAELELKARVF--HFGEYKGDQQDKLLESLNCKVLDVYRHCTG------TQQEANLG- 502
            +  AEL  K R       E K D  D  LE    KV +  +H T       T++ A L  
Sbjct: 935  EINAELTAKKRKLEDECSELKKDIDD--LELTLAKV-EKEKHATENKVKNLTEEMAGLDE 991

Query: 503  TVQMLTIIEHQLDE----LLENLEHVPQVKIEQAERAKEK-ERRIRLREEKLQMQKILQE 557
            T+  LT  +  L E     L++L+ + + K+    +AK K E+++   E  L+ +K L  
Sbjct: 992  TIAKLTKEKKALQEAHQQTLDDLQ-MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCM 1050

Query: 558  EHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
            + L+RA+ + + ++K      L   S       KQQ    L  KE E
Sbjct: 1051 D-LERAKRKLEGDLK------LAQESTMDTENDKQQLNEKLKKKEFE 1090



 Score = 33.1 bits (74), Expect = 0.77
 Identities = 45/196 (22%), Positives = 91/196 (46%), Gaps = 27/196 (13%)

Query: 392  DVFRELEEQNLSLIQNSQETEKTL---EELSHTLKHTQIRMDREVNQLKQWVTTMMMSIT 448
            +   +L ++  +L +  Q+T   L   E+  +TL   + +++++V+ L+        S+ 
Sbjct: 991  ETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEG-------SLE 1043

Query: 449  KEEDTAAELELKARVFHFGEYKGDQQD---------KLLESLNCKVLDVYRHCTGTQQEA 499
            +E+    +LE   R    G+ K  Q+          +L E L  K  ++  +  G  ++ 
Sbjct: 1044 QEKKLCMDLERAKRKLE-GDLKLAQESTMDTENDKQQLNEKLKKKEFEM-SNLQGKIEDE 1101

Query: 500  NLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEH 559
                +Q+   I+ +L   +E LE   +++ E+A RAK +++R  L  E  ++ + L+E  
Sbjct: 1102 QALAIQLQKKIK-ELQARIEELEE--EIEAERASRAKAEKQRSDLSRELEEISERLEE-- 1156

Query: 560  LQRARARAQAEIKKKR 575
                   AQ E+ KKR
Sbjct: 1157 -AGGATSAQIEMNKKR 1171


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 100/515 (19%), Positives = 200/515 (38%), Gaps = 64/515 (12%)

Query: 65  LRDQERNKALSERQ---QQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEA 121
           LR+QE      E +   Q+K +R  +K     ++  +   LR Q +L +++E ++ + E 
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEK-----ELREQEKELREQKELREQEEQMQEQEEK 356

Query: 122 --EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLA 179
             E +   R+    K+   +E+  E E      +QK +        D + R  ++ E L 
Sbjct: 357 MWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQKMR--------DQEERMWEQDERLR 407

Query: 180 TKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQI 239
            KEE R+   EK  E+   + +E          + M+  EK+T+ + EK+ E   +  + 
Sbjct: 408 EKEE-RMREQEKMWEQVEKMREE----------KKMQEQEKKTRDQEEKMQEEERIRERE 456

Query: 240 VNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQ--EKKHSFLKKAKEVSEASKESSV 297
             ++ E     +  +  +  ++ +++   KEW +++  E+K    ++ K   +  K    
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516

Query: 298 NSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGG 357
                D+          MW +E    KK WR     ++      +   ++  +  E    
Sbjct: 517 EEKIRDQ--------EEMWGQE----KKMWR---QEKMREQEDQMWEQEEKMRDQEQKMW 561

Query: 358 DSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEE 417
           D           QE    D EE        ++     RE EE      +  QE E+ ++E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621

Query: 418 LSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKL 477
               +   + +M  +  + K W     M   +EE    +  L  +     E++  Q+ + 
Sbjct: 622 QEEKMWEQEEKMQEQ--EEKMWEQEEKMW-EQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678

Query: 478 LESLNCKVLDVYRHCTGTQQ--------------EANLGTVQMLTIIEHQLDELLENLEH 523
           ++    K+ +  +    TQ+              E+     + +   E  + E  E ++ 
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738

Query: 524 VPQVKIEQAERAKEKERRIRLREEKLQMQKILQEE 558
             +   EQ E   E+E ++  +EEK+  Q+ L E+
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 86/496 (17%), Positives = 202/496 (40%), Gaps = 47/496 (9%)

Query: 67  DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQ-LEDKQEDLEARAEAEHQR 125
           ++ R +   + Q++KT    +KM    ++  +   +R + + + +++E ++ + E   ++
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 126 AFRDYTTWKLTLTKEKNVEPENMSGY---IKQKRQMFLLQYALDVKRREIQRLETLATKE 182
             +++   +L   KEK  E E M      I ++ +    Q  +  + +++ R E +  +E
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543

Query: 183 EARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNI 242
           +   E+ EK  +++  ++D+  R    +  Q  +  ++E K + E+ +  R+       +
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-----KM 598

Query: 243 KSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPG 302
           + E     +  +  +  ++ + +   K W E++EK     +K  E  E   E        
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMW-EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657

Query: 303 DKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGS 362
            + P  K K   +W  E                          Q+  Q  E    +    
Sbjct: 658 QRLPEQKEK---LWEHEKM----------------------QEQEKMQEQEEKIWEQEKM 692

Query: 363 NSPIPPTQEDTDSDGEEPQLYFTEPQQLLDV-FRELEEQNLSLIQNSQETEKTLEELSHT 421
                 TQE      ++ ++   E  +  +   RE EE      +  QE E+ ++E    
Sbjct: 693 EKK---TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749

Query: 422 LKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESL 481
           +   + +M  +  + K W    +    ++     +++ + +++   E   DQ++K+    
Sbjct: 750 MWEQEEKMWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM-RGQ 806

Query: 482 NCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQL---DELLENLEHVPQVKIE-QAERAKE 537
             K+        G Q+E   G  + +   E ++   +E +   E   + K++ Q E+ +E
Sbjct: 807 EEKMRGQEEKMRG-QEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865

Query: 538 KERRIRLREEKLQMQK 553
           +E ++R +EEK++ Q+
Sbjct: 866 QEEKMRGQEEKMREQE 881



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 93/562 (16%), Positives = 221/562 (39%), Gaps = 69/562 (12%)

Query: 54  FHLSGDVDFFLLRDQERNKA-------LSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQL 106
           +H +G++   L     R+K        L++ +   ++ +++    + ++  K+  L+ +L
Sbjct: 175 WHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL 234

Query: 107 QLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALD 166
            L          AE+E      +    K  L + K + P+  +  +++  +M+  +  L 
Sbjct: 235 PL----------AESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQE--EMWRQEEELR 282

Query: 167 VKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKI 226
            + ++I++ E    ++E RL   E  + +          E      + +R  EKE + + 
Sbjct: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQ--------EEKMWRQEKRLREQEKELREQE 334

Query: 227 EKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAK 286
           +++ E ++L  Q   ++ +  +  +  +  +  ++ +++   + W +E++ +    +K +
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE-QKMR 393

Query: 287 EVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQ 346
           +  E   E             ++ K   M  +E     K W  ++ MR           +
Sbjct: 394 DQEERMWEQDER---------LREKEERMREQE-----KMWEQVEKMR--EEKKMQEQEK 437

Query: 347 QGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQ 406
           +     E    + R         +E+     +E ++   E        +E ++Q L   +
Sbjct: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 497

Query: 407 NSQETEKTLEELSHTL--KHTQIRMDREV--NQLKQWVTTMMMSITKEEDTAAELELKAR 462
                ++ ++E    +  +  +IR   E+   + K W    M    ++ED   E E K R
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR---EQEDQMWEQEEKMR 554

Query: 463 VFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLE 522
                    DQ+ K+ +       +        +QE      +     E ++ E  + + 
Sbjct: 555 ---------DQEQKMWDQ------EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599

Query: 523 HVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCR 582
              ++  EQ E+ +E+E +++ +EEK+  Q+   +E  Q  +   Q E   ++   +  +
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE--QEEKMWEQEEKMWEQEEKMWEQ 657

Query: 583 SRPPAHRIKQQSEHTLMDKEEE 604
            R P  + K   EH  M ++E+
Sbjct: 658 QRLPEQKEKLW-EHEKMQEQEK 678



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 28/220 (12%)

Query: 396 ELEEQNLSLIQNSQET---EKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEED 452
           EL EQ   + +  ++    E+ L E    ++  + +M R+  +L++    +     +E++
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR---EQEKE 336

Query: 453 TAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEH 512
              + EL+ +     E   +Q++K+ E                Q+E      + L   E 
Sbjct: 337 LREQKELREQE----EQMQEQEEKMWEQ---------EEKMREQEEKMWRQEERLWEQEK 383

Query: 513 QLDELLENLEHVPQVKIEQAERAKEKERRIRLRE------EKLQMQKILQEEHLQRARAR 566
           Q+ E  + +    +   EQ ER +EKE R+R +E      EK++ +K +QE+  ++ R +
Sbjct: 384 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE-KKTRDQ 442

Query: 567 AQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
            +   +++R R    + R     +++Q E   M K+EE +
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEK--MQKQEENM 480



 Score = 30.8 bits (68), Expect = 3.8
 Identities = 24/101 (23%), Positives = 48/101 (47%), Gaps = 5/101 (4%)

Query: 511 EHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKL-QMQKILQEEHL----QRARA 565
           E +L E  + +    +    Q ER +E+E ++R +EEK+ + +K L+E+      Q    
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337

Query: 566 RAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
           R Q E++++  +      +      K + +   M ++EE L
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378


>gi|226494053 coiled-coil domain containing 42 isoform 1 [Homo
           sapiens]
          Length = 316

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 36/198 (18%)

Query: 104 RQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQY 163
           R LQ+  K  ++E  +E+         + W L    EK  E E M   + QK++MF    
Sbjct: 22  RLLQMLQKLPNVEGASESP--------SIWLL----EKKKETEIMHQTMVQKKKMFQ--- 66

Query: 164 ALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK 223
                    +R+ETL  + E  L   E  L+      ++F++END   ++AM+ A KE +
Sbjct: 67  ---------RRMETLNLRWE-ELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERE 116

Query: 224 AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEK------ 277
            K + + E+     ++V ++ E  R    LK Y ++  +L K+      EE  +      
Sbjct: 117 LKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKVVENSEFEEIHEVIARYK 176

Query: 278 -----KHSFLKKAKEVSE 290
                +H  ++ A+E  E
Sbjct: 177 TLVSMRHDLMQSAQEGQE 194


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 129/623 (20%), Positives = 244/623 (39%), Gaps = 91/623 (14%)

Query: 13   MTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNK 72
            +T  K  LE        S E+  +K+ R + E           L+ +    L  D+++  
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQ--EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ-- 1075

Query: 73   ALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQL-QLEDKQEDLEARAEAEHQRAFRDYT 131
             L ER ++K   ++          A  + L+++L +L+ + E+LE   EAE     R   
Sbjct: 1076 -LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAE-----RTAR 1129

Query: 132  TWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRR-EIQRLETLATKEEARLERAE 190
                 L  + + E E +S  +++      +Q  ++ KR  E Q++     +   + E   
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189

Query: 191  KSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT---QIVNIKSEIS 247
             +L K  A   + V E         R  +K  K K E  LE+ D+T+   QI+  K+ + 
Sbjct: 1190 AALRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1246

Query: 248  RFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEA-----SKESSVNSTPG 302
            +   T                   LE+Q  +H    KA+E   +     S+ + + +  G
Sbjct: 1247 KMCRT-------------------LEDQMNEHR--SKAEETQRSVNDLTSQRAKLQTENG 1285

Query: 303  DKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGS 362
            +    +  K + +     Q T+   +   T +L      L    +       +   +R  
Sbjct: 1286 ELSRQLDEKEALI----SQLTRG--KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339

Query: 363  NSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFR------------ELEEQNLSLIQNSQE 410
               +    E+      E Q   ++    +  +R            ELEE    L Q  QE
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399

Query: 411  TEKTLEELS---HTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFG 467
             E+ +E ++    +L+ T+ R+  E+  L       M+ + +    AA L+ K R F   
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDL-------MVDVERSNAAAAALDKKQRNF--- 1449

Query: 468  EYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQV 527
                   DK+L     K  +       +Q+EA   + ++  + ++  +E LE+LE   + 
Sbjct: 1450 -------DKILAEWKQKYEESQSELESSQKEARSLSTELFKL-KNAYEESLEHLETFKRE 1501

Query: 528  KIEQAERAKEKERRI-----RLRE-EKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVC 581
                 E   +   ++      + E EK++ Q   ++  LQ A   A+A ++ + G+ L  
Sbjct: 1502 NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL-- 1559

Query: 582  RSRPPAHRIKQQSEHTLMDKEEE 604
            R++   ++IK + E  L +K+EE
Sbjct: 1560 RAQLEFNQIKAEIERKLAEKDEE 1582



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 116/607 (19%), Positives = 227/607 (37%), Gaps = 106/607 (17%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            E ++ L E++   +     K+TY+ ++      L+RQL+ E K ++  A A  +  R   
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLE----DLKRQLEEEVKAKNALAHA-LQSARHDC 1340

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLER 188
            D    +     E   E + +      +   +  +Y  D  +R  + LE    K   RL+ 
Sbjct: 1341 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQE 1399

Query: 189  AEKSLEKDAALFDEFVREN------------DCSSVQAMRAAEKETKAKIEKIL------ 230
            AE+++E   A      +              D     A  AA  + +   +KIL      
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459

Query: 231  -------------EIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPK-----EWL 272
                         E R L+T++  +K+    +E++L+H + +K     L  +     E L
Sbjct: 1460 YEESQSELESSQKEARSLSTELFKLKNA---YEESLEHLETFKRENKNLQEEISDLTEQL 1516

Query: 273  EEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQT 332
                K    L+K ++  EA K    ++        ++   +S+  +EG+  +    F Q 
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSA--------LEEAEASLEHEEGKILRAQLEFNQI 1568

Query: 333  MRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLD 392
                         ++ ++  E      R     +   Q   D++           +++  
Sbjct: 1569 KA--------EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 1620

Query: 393  VFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREV----------------NQL 436
               E+E Q     + + E +K ++ L   LK TQI++D  V                N L
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1680

Query: 437  KQWVTTMMMSITKEEDTA---AELEL-----KARVFHFGEYKGDQQDKLLES----LNCK 484
             Q     + ++ ++ + +   AE EL     + ++ H        Q K +++    L  +
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740

Query: 485  VLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERR--- 541
            V +  + C   +++A         + E +L +  +   H+ ++K    +  K+ + R   
Sbjct: 1741 VEEAVQECRNAEEKAKKAITDAAMMAE-ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799

Query: 542  ---IRLREEKLQMQKILQEEHLQRARARA---QAEIKKKRGRTLVCRSRPPAHRIKQQSE 595
               I L+  K Q+QK+        AR R    + E ++KR    V   R    RIK+ + 
Sbjct: 1800 AEQIALKGGKKQLQKL-------EARVRELENELEAEQKRNAESVKGMRKSERRIKELTY 1852

Query: 596  HTLMDKE 602
             T  D++
Sbjct: 1853 QTEEDRK 1859



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 52/225 (23%), Positives = 98/225 (43%), Gaps = 24/225 (10%)

Query: 395  RELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVN---QLKQWVTTMMMSITKEE 451
            +ELEE+ +SL+Q   + +  ++     L   + R D+ +    QL+  V  M   +  EE
Sbjct: 871  KELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEE 930

Query: 452  DTAAELELKARVF--HFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTI 509
            +  AEL  K R       E K D  D  LE    KV +  +H T  + +     +  L  
Sbjct: 931  EMNAELTAKKRKLEDECSELKRDIDD--LELTLAKV-EKEKHATENKVKNLTEEMAGLDE 987

Query: 510  IEHQLDELLENLEHVPQVKIEQAERAKEK-----ERRIRLREEKLQMQKILQEE-----H 559
            I  +L +  + L+   Q  ++  +  ++K     + +++L ++   ++  L++E      
Sbjct: 988  IIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047

Query: 560  LQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEE 604
            L+RA+ + + ++K      L   S       KQQ +  L  K+ E
Sbjct: 1048 LERAKRKLEGDLK------LTQESIMDLENDKQQLDERLKKKDFE 1086



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 51/197 (25%), Positives = 90/197 (45%), Gaps = 42/197 (21%)

Query: 388  QQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQ-IRMD--REVNQLKQWVTTMM 444
            QQ LD  +  E++  +L +   + E+ +++L  +L+  + +RMD  R   +L+  +    
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQ 1063

Query: 445  MSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTV 504
             SI   E+   +L+ + +          ++D  L +LN ++ D          E  LG+ 
Sbjct: 1064 ESIMDLENDKQQLDERLK----------KKDFELNALNARIED----------EQALGS- 1102

Query: 505  QMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQ--MQKILQE--EHL 560
                    QL + L+ L    Q +IE+ E   E ER  R + EKL+  + + L+E  E L
Sbjct: 1103 --------QLQKKLKEL----QARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 561  QRA--RARAQAEIKKKR 575
            + A      Q E+ KKR
Sbjct: 1151 EEAGGATSVQIEMNKKR 1167


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 115/548 (20%), Positives = 208/548 (37%), Gaps = 113/548 (20%)

Query: 32  EENPKKQARKNEEHGPDP---SANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQK 88
           EEN K+   K EE    P   S     +   V+      QE    +S +  Q +     K
Sbjct: 181 EENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE-EPK 239

Query: 89  MTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENM 148
                +  +   S   +++ EDK+     RAEAE  R   +    ++   ++K +  E  
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKE-----RAEAERARLEAEERE-RIKAEQDKKIADERA 293

Query: 149 SGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVREND 208
               ++K        A + +RRE +  E +  +E+   E  ++  E++    +E  R  +
Sbjct: 294 RIEAEEKAA------AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347

Query: 209 CSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSP 268
               +  RAAE+  +                  IK E  R  +  +  +  ++       
Sbjct: 348 ----EEKRAAEERQR------------------IKEEEKRAAEERQRARAEEE------E 379

Query: 269 KEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWR 328
           K  +EEQ++     K+ +E   A +E+ +      KG  ++ K    W  E +  +    
Sbjct: 380 KAKVEEQKRN----KQLEEKKHAMQETKI------KGEKVEQKIEGKWVNEKKAQEDK-- 427

Query: 329 FLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQ 388
            LQT  L +      +  Q  +       +    + P    +E  D   ++ +    E +
Sbjct: 428 -LQTAVLKKQGEEKGTKVQAKR-------EKLQEDKPTFKKEEIKDEKIKKDKEPKEEVK 479

Query: 389 QLLDV---FRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMM 445
             +D    F E++ QN              E ++H LKHT+    R   +          
Sbjct: 480 SFMDRKKGFTEVKSQNG-------------EFMTHKLKHTENTFSRPGGRASV------- 519

Query: 446 SITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQ 505
             TKE + A ++E   R+      +G+ + +  E L  K           QQEA L    
Sbjct: 520 -DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQK-----------QQEAAL---- 563

Query: 506 MLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARA 565
                  +L+EL +  E   +V  E+ +R K++E   +LREE+   +K   +E ++R RA
Sbjct: 564 -------ELEELKKKREERRKVLEEEEQRRKQEEADRKLREEE---EKRRLKEEIERRRA 613

Query: 566 RAQAEIKK 573
            A  + +K
Sbjct: 614 EAAEKRQK 621



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 109/598 (18%), Positives = 245/598 (40%), Gaps = 91/598 (15%)

Query: 66  RDQERNKALSERQQQKTM-RVHQKMTYSSKVS-----AKHTSLRRQLQLEDKQEDLEARA 119
           R + R + L ++Q+++++ +V  ++  +++ S     AK T+   Q++ +D+   LE  A
Sbjct: 42  RRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101

Query: 120 EAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLA 179
             E +R  R     +  L ++K  +P      +           +L  +R +    E   
Sbjct: 102 RREERRQKR----LQEALERQKEFDPTITDASL-----------SLPSRRMQNDTAENET 146

Query: 180 TKEEARLERAEKSLE-KDAALFDEFVRENDCSSVQAMRAAEKETKAK------------- 225
           T++E + E  ++  E ++     +  ++ND    +  +  +KE + +             
Sbjct: 147 TEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGEN 206

Query: 226 -IEKILEIRDLTTQ----IVNIKS-EISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKH 279
            +E ++E +   +Q    ++++K+ +IS  E   K  +  +    ++S  E +EE++K+ 
Sbjct: 207 QVEVMVEEKTTESQEETVVMSLKNGQISSEEP--KQEEEREQGSDEISHHEKMEEEDKER 264

Query: 280 SFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWR--FLQTMRLGR 337
           +  ++A+   EA +   + +    K   I  + + + A+E    ++  R    +  R+  
Sbjct: 265 AEAERAR--LEAEERERIKAEQDKK---IADERARIEAEEKAAAQERERREAEERERMRE 319

Query: 338 SPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFREL 397
                +  +Q  +  E    + R         +E+     EE Q    E ++  +  +  
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQR------IKEEEKRAAEERQRIKEEEKRAAEERQRA 373

Query: 398 --EEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDRE--------VNQLKQWVTTMMMSI 447
             EE+  + ++  Q+  K LEE  H ++ T+I+ ++         VN+ K     +  ++
Sbjct: 374 RAEEEEKAKVEE-QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAV 432

Query: 448 TKEEDTAAELELKAR---------VFHFGEYKGDQ--QDKLLESLNCKVLDVYRHCTGTQ 496
            K++      +++A+          F   E K ++  +DK  +      +D  +  T  +
Sbjct: 433 LKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 492

Query: 497 QEANLGTVQMLTIIEHQLDEL-------LENLEHVPQVKIEQAERAKEKERRIRLREEKL 549
            +        L   E+             +  E  PQV   +A +  E+ RR R   E  
Sbjct: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQV---EAGKRLEELRRRRGETESE 549

Query: 550 QMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELL 607
           + +K+ Q+   Q+  A    E+KKKR             R +++++  L ++EE+  L
Sbjct: 550 EFEKLKQK---QQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 604



 Score = 33.5 bits (75), Expect = 0.59
 Identities = 78/426 (18%), Positives = 171/426 (40%), Gaps = 53/426 (12%)

Query: 168 KRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIE 227
           +RRE++R +    +EE RLE    + +++    +E  RE         R A +E   + +
Sbjct: 6   RRRELRRQK----REEMRLEAERIAYQRNDDDEEEAARER-------RRRARQERLRQKQ 54

Query: 228 KILEIRDLTTQI-VNIKSEISRFE--DTLKHYKVYKD----FLYKLSPKEWLEEQEKKHS 280
           +   +  +T Q+ VN ++ +   E   T  + +V  D    FL +L+ +E     E++  
Sbjct: 55  EEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARRE-----ERRQK 109

Query: 281 FLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPS 340
            L++A E     ++   + T  D    +  +       E + T+K  +            
Sbjct: 110 RLQEALE-----RQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKS----------- 153

Query: 341 YLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQ 400
              S Q+  +  E+         +     +E+   D E+ +    +P++       + E 
Sbjct: 154 --ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKR-----GSIGEN 206

Query: 401 NLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMS----ITKEEDTAAE 456
            + ++   + TE   E +  +LK+ QI  +    + ++   +  +S    + +E+   AE
Sbjct: 207 QVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAE 266

Query: 457 LELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDE 516
            E         E    +QDK +     ++    +     ++       + +   E +  E
Sbjct: 267 AERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE 326

Query: 517 LLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIK---K 573
             + ++   +   E+ +R KE+E+R     ++++ ++    E  QRARA  + + K   +
Sbjct: 327 ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQ 386

Query: 574 KRGRTL 579
           KR + L
Sbjct: 387 KRNKQL 392


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 109/567 (19%), Positives = 232/567 (40%), Gaps = 68/567 (11%)

Query: 72   KALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQL-----QLEDKQEDLEARAEAEHQRA 126
            + L  +   + +++ +++   +++ A+   LR +L     +LE+   DLEAR E E +R 
Sbjct: 872  ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931

Query: 127  FRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARL 186
                   K      + +E E +      ++++ L +   + K ++++  + +   +  +L
Sbjct: 932  QHLQAEKKKMQQNIQELE-EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL 990

Query: 187  ERAEKSLEKDAALFDEFVRENDCSS-----------------VQAMRAAEKE------TK 223
             + +K LE   A F   + E +  S                  + +R  EK+      T+
Sbjct: 991  AKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR 1050

Query: 224  AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLK 283
             K+E   +  DL+ QI  ++++I+  +  L   K  ++    L+  E  EE  +K+  LK
Sbjct: 1051 RKLEG--DSTDLSDQIAELQAQIAELKMQLA--KKEEELQAALARVE--EEAAQKNMALK 1104

Query: 284  KAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLS 343
            K +E+     ES ++    D          S  A   +  K      Q   LG     L 
Sbjct: 1105 KIREL-----ESQISELQED--------LESERASRNKAEK------QKRDLGEELEALK 1145

Query: 344  SPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLS 403
            +  + +  S ++  + R          + T    EE + +  + Q++     +  E+   
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLE--EEAKTHEAQIQEMRQKHSQAVEELAE 1203

Query: 404  LIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARV 463
             ++ ++  +  LE+   TL++ +  +  EV  L Q          K E    EL++K   
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK--- 1260

Query: 464  FHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM---LTIIEHQLDELLEN 520
            F+ GE    +    +  L  ++ +V    TG   +++  + ++    + +E QL +  E 
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNV----TGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316

Query: 521  LEHVPQVKIEQAERAKE-KERRIRLREEKLQMQKILQEEHLQRARARAQ-AEIKKKRGRT 578
            L+   + K+  + + K+ ++ +   RE+  + ++       Q A   AQ A++KKK   +
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376

Query: 579  LVCRSRPPAHRIKQQSEHTLMDKEEEE 605
            + C       + K Q +   + +  EE
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEE 1403



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 127/614 (20%), Positives = 239/614 (38%), Gaps = 111/614 (18%)

Query: 55   HLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQED 114
            HL  +        QE  + L E +  +     +K+T  +K+         Q+ LED+   
Sbjct: 933  HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE---EEQIILEDQNCK 989

Query: 115  LEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQR 174
            L    +    R   ++TT    LT+E+  E       +K K +  +      ++R E QR
Sbjct: 990  LAKEKKLLEDR-IAEFTT---NLTEEE--EKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043

Query: 175  LET-------------------------------LATKEE------ARLERAEKSLEKDA 197
             E                                LA KEE      AR+E  E++ +K+ 
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVE--EEAAQKNM 1101

Query: 198  ALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYK 257
            AL      E+  S +Q    +E+ ++ K EK  + RDL  ++  +K+E+   EDTL    
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEK--QKRDLGEELEALKTEL---EDTLDS-- 1154

Query: 258  VYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSM-- 315
                     + +E   ++E++ + LKK  E    + E+ +          ++  A  +  
Sbjct: 1155 -------TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207

Query: 316  WAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTD- 374
              +     +K  + L+  R G   + +    QG        GDS      +    ++   
Sbjct: 1208 TKRVKANLEKAKQTLENER-GELANEVKVLLQGK-------GDSEHKRKKVEAQLQELQV 1259

Query: 375  --SDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELS---HTLKHTQIRM 429
              ++GE  +    +    L V  EL+     L Q+  ++ K  ++ S     L+ TQ  +
Sbjct: 1260 KFNEGERVRTELADKVTKLQV--ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317

Query: 430  DREVNQLKQWVTTMMMSITKE---------EDTAAELELKARVFHFGEYKGDQQDKLLES 480
              E N+ K  ++T +  +  E         E+  A+  L+ ++        D + K+ +S
Sbjct: 1318 QEE-NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376

Query: 481  LNC--------KVLDVYRHCTGTQQEANLGTVQML----TIIEHQLDELLENLEHVPQVK 528
            + C        + L         + E  +     L    T ++ +LD+LL +L+H  Q  
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436

Query: 529  IEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAH 588
                ++ K+ ++   L EEK    K  +E      R RA+AE ++K  + L   +R    
Sbjct: 1437 CNLEKKQKKFDQ--LLAEEKTISAKYAEE------RDRAEAEAREKETKAL-SLARALEE 1487

Query: 589  RIKQQSEHTLMDKE 602
             ++Q++E   ++K+
Sbjct: 1488 AMEQKAELERLNKQ 1501



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 112/533 (21%), Positives = 220/533 (41%), Gaps = 64/533 (12%)

Query: 65   LRDQERNKALSERQQQKTMRVHQKMTYSSKV--SAKHTSLRRQLQLEDKQEDLEARA-EA 121
            L   +R KA  E+ +Q       ++    KV    K  S  ++ ++E + ++L+ +  E 
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264

Query: 122  EHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQ---KRQMFLLQY-ALDVKRREIQRLET 177
            E  R        KL       VE +N++G + Q   K       + AL+ + ++ Q L  
Sbjct: 1265 ERVRTELADKVTKL------QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318

Query: 178  LATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTT 237
               +++  L    K +E +   F E + E            E+E K  +EK  +I  L  
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEE------------EEEAKHNLEK--QIATLHA 1364

Query: 238  QIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSV 297
            Q+ ++K ++   ED++   +  ++   KL     LE   ++H     A +  E +K + +
Sbjct: 1365 QVADMKKKM---EDSVGCLETAEEVKRKLQKD--LEGLSQRHEEKVAAYDKLEKTK-TRL 1418

Query: 298  NSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGG 357
                 D    +  +  S    E    KK  +F Q +   ++ S   + ++    +E+   
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLE----KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 358  DSRGSNSPIPPTQEDTDSDGEEPQL---YFTEPQQLL----DVFR---ELEEQNLSLIQN 407
            +++   S     +E  +   E  +L   + TE + L+    DV +   ELE+   +L Q 
Sbjct: 1475 ETKAL-SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 408  SQETEKTLEELSHTLKHTQ-IRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHF 466
             +E +  LEEL   L+ T+  ++  EVN   Q +        +  D  +E + K  V   
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591

Query: 467  GEYKGDQQDK---------LLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDEL 517
             E + + +D+           + L   + D+  H     +  +   ++ L  ++ Q+ + 
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD-EAIKQLRKLQAQMKDC 1650

Query: 518  LENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAE 570
            +  L+     + E   +AKE E++++  E ++     LQEE     RA+ QA+
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQ---LQEELAAAERAKRQAQ 1700



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 96/517 (18%), Positives = 199/517 (38%), Gaps = 77/517 (14%)

Query: 61   DFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARA- 119
            D  +  D +R  A +  ++QK  +  Q +     +SAK+   R + + E ++++ +A + 
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQK--KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481

Query: 120  ----------EAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKR----QMFLLQYAL 165
                      +AE +R  + + T    L   K+   +++    K KR    Q+  ++  L
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541

Query: 166  DVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK-- 223
            +    E+Q  E    + E  L+  +   E+D    DE   E     V+ +R  E E +  
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601

Query: 224  ---------AKIEKILEIRDLTTQIVNI-KSEISRFEDTLKHYKVYKDFLYKL----SPK 269
                     A+ +  ++++DL   I +  K+     +   K     KD + +L    + +
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASR 1661

Query: 270  EWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGK---ASSMWAKEGQGTKKP 326
            E +  Q K++    K+ E      +  + +    K    + +   A  +    G+G    
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKG---- 1717

Query: 327  WRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTE 386
                  + L       +   Q  +  E   G++   N  +       D    +  L  + 
Sbjct: 1718 -----ALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772

Query: 387  PQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMS 446
             Q+  +  ++LE QN  L    QE E T++      K +   ++ ++ QL++     + +
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKS---KYKASITALEAKIAQLEE----QLDN 1825

Query: 447  ITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQM 506
             TKE   A +             +  + +K L+ +  +V D  R+    + +A+  + ++
Sbjct: 1826 ETKERQAACK-------------QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872

Query: 507  LTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIR 543
                  QL   LE  E       E+A+RA    R+++
Sbjct: 1873 -----KQLKRQLEEAE-------EEAQRANASRRKLQ 1897


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 129/597 (21%), Positives = 236/597 (39%), Gaps = 140/597 (23%)

Query: 66   RDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLE---------------- 109
            ++Q RN   S +Q Q+T+      T  SK+S +   + R L +E                
Sbjct: 963  QEQLRNALESLKQHQETIN-----TLKSKISEE---VSRNLHMEENTGETKDEFQQKMVG 1014

Query: 110  -DKQEDLEARAEAEHQRAFRDYTTWK-----LTLTKEKNVEPENMSGYIKQKRQMFLLQY 163
             DK++DLEA+         +D    +      +L +EKN   + +   I +K Q+     
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL----- 1069

Query: 164  ALDVKRREIQRLE-TLATKEEARL--ERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEK 220
              D+K    + +E T+  +EE RL  +  +K  E  A   +  +++    S    R AE 
Sbjct: 1070 KTDLK----ENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125

Query: 221  ETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEW-LEEQEKKH 279
            E K K EK  ++++   Q++N++ E+S  +  +   +  K+   +L  KE  LE  E + 
Sbjct: 1126 EEKLK-EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN---ELKNKELTLEHMETER 1181

Query: 280  SFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSP 339
              L+ A++++E  +E  V S                  KE +  K+  +  +T R     
Sbjct: 1182 --LELAQKLNENYEE--VKSI----------------TKERKVLKELQKSFETER----- 1216

Query: 340  SYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEE 399
                                RG    I  T   T  + +   ++  E Q+ +D  R    
Sbjct: 1217 -----------------DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259

Query: 400  QNLSLIQNSQETEKTLEELSHTLK--HTQIRMDREVNQLKQWVTTM-------MMSITKE 450
            +  + I N+Q+ EK+  +L   +   H +  +   V ++ +   TM         S TK+
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319

Query: 451  EDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTII 510
              T A +E++ R+    +++  Q++  ++SL             T++  NL T++    +
Sbjct: 1320 STTLARIEME-RLRLNEKFQESQEE--IKSL-------------TKERDNLKTIKEALEV 1363

Query: 511  EHQLDELLENLEHV------PQVKIEQAERAKEKERR------------------IRLRE 546
            +H  D+L E++          Q K EQ+   KEK+                    +R+  
Sbjct: 1364 KH--DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421

Query: 547  EKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEE 603
            E L + K LQE H +      + +  ++    L   S      IK+     L  +EE
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 122/614 (19%), Positives = 240/614 (39%), Gaps = 109/614 (17%)

Query: 56   LSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDL 115
            LS  V+    ++ +  K       QK   +   ++YS +      S+    Q++    D 
Sbjct: 577  LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLE------SIEDPKQMKQTLFDA 630

Query: 116  EARA-EAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQR 174
            E  A +A+ + AF      +L   KEK    E  + Y + +  + L Q  L+ K++    
Sbjct: 631  ETVALDAKRESAFLRSENLEL---KEKM--KELATTYKQMENDIQLYQSQLEAKKK---- 681

Query: 175  LETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQA---MRAAEKETKAKIEKILE 231
               +    E  L+ A   + K  +L D  V ++   +++    +   +KE   ++E+   
Sbjct: 682  ---MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEA 738

Query: 232  IRD---LTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFL-KKAKE 287
            +R+   L +++ ++ SE+ R                    KE  ++ E+ H    +K K 
Sbjct: 739  LREEVILLSELKSLPSEVERLR------------------KEIQDKSEELHIITSEKDKL 780

Query: 288  VSEA-SKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSY---LS 343
             SE   KES V     + G      A++      + T + ++  +T+ +     Y   L 
Sbjct: 781  FSEVVHKESRVQGLLEEIGKTKDDLATTQ--SNYKSTDQEFQNFKTLHMDFEQKYKMVLE 838

Query: 344  SPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQN-- 401
              ++ +Q   +   +++  +S +   + +     +E Q    E Q+ L+   +L+EQ   
Sbjct: 839  ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN 898

Query: 402  ---------------LSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWV-TTMMM 445
                              +Q + E  KTL +    LK  Q  +  E +QLK  +  T+ M
Sbjct: 899  RDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM 958

Query: 446  SITKEEDTAAELE-----------LKARV-------FHFGEYKGDQQDKL---------- 477
            +I  +E     LE           LK+++        H  E  G+ +D+           
Sbjct: 959  NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKK 1018

Query: 478  --LESLNCKVL--DVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAE 533
              LE+ N + L  DV  +    QQ      +Q    ++  L+ ++   E +     E  E
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 534  RAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVC-RSRPPAHRIKQ 592
               E +  +RL  ++L+ Q+ +  +    A       IKK+   +  C R      ++K+
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHA-------IKKEGELSRTCDRLAEVEEKLKE 1131

Query: 593  QSEHTLMDKEEEEL 606
            +S+  L +K+++ L
Sbjct: 1132 KSQQ-LQEKQQQLL 1144



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 22/76 (28%), Positives = 41/76 (53%), Gaps = 7/76 (9%)

Query: 509 IIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQE--EHLQR---- 562
           +++    E+++  + + +V +E   +A EK++  +L EEK  +QK+  E  E+L R    
Sbjct: 344 LLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVT 403

Query: 563 -ARARAQAEIKKKRGR 577
            +    Q E+K KR R
Sbjct: 404 SSSLTLQQELKAKRKR 419



 Score = 30.0 bits (66), Expect = 6.5
 Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 18/121 (14%)

Query: 187 ERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEK--------ILEIRDLTTQ 238
           E  E  L    A +D  V +      + +R  ++E + K+++         LE +    Q
Sbjct: 494 ENIESELNSLRADYDNLVLD-----YEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548

Query: 239 IVNIKSEISRFEDTLKHYKVY-KDFLYKLSPK-EWLEEQEKKHSFLKKAKEVSEASKESS 296
            + +  EIS  ++ +KH +VY +D   +LS K E L E+E +   +KK +E  ++ K  +
Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQ---IKKLQEYIDSQKLEN 605

Query: 297 V 297
           +
Sbjct: 606 I 606


>gi|226528968 coiled-coil domain containing 42 isoform 2 [Homo
           sapiens]
          Length = 242

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 44/163 (26%), Positives = 76/163 (46%), Gaps = 25/163 (15%)

Query: 104 RQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQY 163
           R LQ+  K  ++E  +E+         + W L    EK  E E M   + QK++MF    
Sbjct: 22  RLLQMLQKLPNVEGASESP--------SIWLL----EKKKETEIMHQTMVQKKKMFQ--- 66

Query: 164 ALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETK 223
                    +R+ETL  + E  L   E  L+      ++F++END   ++AM+ A KE +
Sbjct: 67  ---------RRMETLNLRWE-ELGVKEAQLKAHIQKSEQFIQENDQKRIRAMKKANKERE 116

Query: 224 AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKL 266
            K + + E+     ++V ++ E  R    LK Y ++  +L K+
Sbjct: 117 LKCQHMQELTKRKQEMVALRLEHQRLSAKLKDYYIFNKYLEKV 159


>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 86/417 (20%), Positives = 162/417 (38%), Gaps = 63/417 (15%)

Query: 64   LLRDQERNKALSERQQQKTMR--VHQKMTYSS-------KVSAKH--TSLRRQLQLEDKQ 112
            LL+D+E + A S     +++   +HQ   +SS       +V A H  TS  R+L +  + 
Sbjct: 717  LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD 776

Query: 113  EDLEA--------------------------RAEAEHQRAFRDYTTWKLTLTKEKNVEPE 146
            E L A                           A    Q    +   W++T  + K    E
Sbjct: 777  EQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSK---AE 833

Query: 147  NMSGYIKQKRQMFLLQYALDVKRREIQRLET-LATKEEARLERAEKSLEKDAALFDEFVR 205
            +M   ++++R++   Q A++  R E++R ++ L  ++++ + +  +   + AA + EF  
Sbjct: 834  SMQRALEEQRKVTAQQMAME--RAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSA 891

Query: 206  ENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYK 265
            +   S  +A R AE+  +   ++   +  L  +   +K   S      K     +  L +
Sbjct: 892  QQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQ 951

Query: 266  LSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEG---QG 322
               +  LE++    + L+      E    S V S   ++G     +A  + A++    Q 
Sbjct: 952  ERQELRLEKERINATALRVKLRAEEVESMSKVASEKYEEGERALREAQQVQAEQQARLQA 1011

Query: 323  TKKPWRFLQTMRLGRSPSYLSSPQQGSQ--------PSESSG------GDSRGSNSPIPP 368
             ++    L+         +LS  QQ  Q        PS   G      G +  S S + P
Sbjct: 1012 VQQQQERLRKQEQHMHQEHLSLAQQRLQLDRARQDLPSSLVGLFPRAQGPAASSQSALMP 1071

Query: 369  TQEDTDSDGEEPQLYFTEPQQL---LDVFRELEEQNLSLIQNSQETEKTLEELSHTL 422
                T    + P      P  L   L + R + EQ+   ++N Q   +TL++ S+ L
Sbjct: 1072 PAPTTRWCSQPPTGLDPSPLHLHARLALLRHMAEQDRDFLENEQFFLETLKKGSYNL 1128



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 52/247 (21%), Positives = 104/247 (42%), Gaps = 17/247 (6%)

Query: 374 DSDGEEPQLYFTEPQQLLDVFRELEEQ--NLSLIQNSQETEKTLEELSHT-----LKHTQ 426
           + D E  +L   +   +LD+ R+ EEQ   L L+++ +E +      SHT     + H  
Sbjct: 685 EKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKD-REVDAATSATSHTRSLNSIIHQM 743

Query: 427 IRMDREVNQLKQWVTTMMMSITKEEDTAA---ELELKARVFHFGEYKGDQQDKLLESLNC 483
            +    +++L   V    ++ ++E +      + +L+A     G+ + D +++   S   
Sbjct: 744 EKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEE--RSRQQ 801

Query: 484 KVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQA--ERAKEKERR 541
           +V+         Q          +T  + + + +   LE   +V  +Q   ERA+ +  +
Sbjct: 802 EVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAK 861

Query: 542 IRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMD- 600
             L EE+  +     EE  + A   A+   ++K  +    R    A ++  Q E TL+  
Sbjct: 862 SALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISL 921

Query: 601 -KEEEEL 606
            KE+ EL
Sbjct: 922 AKEQAEL 928



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 46/210 (21%), Positives = 86/210 (40%), Gaps = 12/210 (5%)

Query: 403 SLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKAR 462
           S +  SQE E  + +    L+  Q R+ ++   +++  +     I K E   A L  ++R
Sbjct: 760 SHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKME---ARLNEQSR 816

Query: 463 VFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQML--TIIEHQLDELLEN 520
           +     ++   +    ES+  + L+  R  T  Q       ++     ++E Q   +L+ 
Sbjct: 817 LLEQERWRVTAEQSKAESMQ-RALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKC 875

Query: 521 LEHVPQVKIEQAERAKE----KERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRG 576
            E   ++  E AE + +    KER  R  E  LQ+    Q E    + A+ QAE+K +  
Sbjct: 876 GEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDT--QREGTLISLAKEQAELKIRAS 933

Query: 577 RTLVCRSRPPAHRIKQQSEHTLMDKEEEEL 606
                  +  A R   + E   +  E+E +
Sbjct: 934 ELRAEEKQLAAERAALEQERQELRLEKERI 963



 Score = 33.9 bits (76), Expect = 0.45
 Identities = 27/114 (23%), Positives = 56/114 (49%), Gaps = 8/114 (7%)

Query: 496 QQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKIL 555
           Q E  LG++Q     +HQ D  L    H  ++K+ +    +++E R+R   E+L  + + 
Sbjct: 605 QHELLLGSLQQ----QHQADLELIESAHRSRIKVLETSY-QQREERLRRENEELSARYLS 659

Query: 556 QEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMD--KEEEELL 607
           Q +  ++ARA   A+  ++R   +         R+++    +++D  ++ EE L
Sbjct: 660 QCQEAEQARAELTAQ-HQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQL 712



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 97/502 (19%), Positives = 202/502 (40%), Gaps = 58/502 (11%)

Query: 102  LRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLL 161
            L  Q+QL+    +L+A  E  H +A       ++   + +  + E + G ++Q+ Q  L 
Sbjct: 565  LAAQVQLQCSPAELQA--ELLHSQARLAELEAQVRKLELERAQHELLLGSLQQQHQADL- 621

Query: 162  QYALDVKRREIQRLETLATKEEARLERAEKSLE----KDAALFDEFVRENDCSSVQAMRA 217
            +      R  I+ LET   + E RL R  + L           ++   E      + + A
Sbjct: 622  ELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQRRLAA 681

Query: 218  AEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEK 277
              +E   ++E++ E++     I++++ +    E+ L+  K+ KD     +       +  
Sbjct: 682  IAQEKDQEMERLRELQ--RASILDMRRD---HEEQLQRLKLLKDREVDAATSATSHTRSL 736

Query: 278  K---HSFLKKAKEVSEASK--ESSVNSTPGDKGPGIKGKASSMWAKEG-----QGTKKPW 327
                H   K +  + E S   E+S  +T  ++  GI+ +   + A +      Q   +  
Sbjct: 737  NSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDMEEE 796

Query: 328  RFLQTMRLGRSPSYLSSPQQG-SQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTE 386
            R  Q   +G+  + L+   +   Q       +   + S     +E      ++  +   E
Sbjct: 797  RSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAE 856

Query: 387  PQQLLDVFRELEEQNLSLIQNSQETEKTLEE---LSHTLKHTQIRMDREVNQLKQWVTTM 443
             ++       LEEQ   +++  +E  +   E    S   K ++ R +RE  +  Q  T  
Sbjct: 857  LERAKSAL--LEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQR 914

Query: 444  ---MMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEAN 500
               ++S+ KE+   AEL+++A      E + +++    E      L+  R     ++E  
Sbjct: 915  EGTLISLAKEQ---AELKIRA-----SELRAEEKQLAAERA---ALEQERQELRLEKERI 963

Query: 501  LGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERA------KEKERRIRLREEKLQMQKI 554
              T   + +   ++    E++  V   K E+ ERA       + E++ RL+  + Q +++
Sbjct: 964  NATALRVKLRAEEV----ESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERL 1019

Query: 555  ------LQEEHLQRARARAQAE 570
                  + +EHL  A+ R Q +
Sbjct: 1020 RKQEQHMHQEHLSLAQQRLQLD 1041


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 111/512 (21%), Positives = 213/512 (41%), Gaps = 85/512 (16%)

Query: 69   ERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFR 128
            E    L+E+ Q +T    +     ++++AK      + +LE+   DLE+R E E +R   
Sbjct: 887  EEKNILAEQLQAETELFAEAEEMRARLAAK------KQELEEILHDLESRVEEEEER--- 937

Query: 129  DYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLER 188
                    L  EK    + M  +I+       L+  LD +    Q+L+      EA++++
Sbjct: 938  -----NQILQNEK----KKMQAHIQD------LEEQLDEEEGARQKLQLEKVTAEAKIKK 982

Query: 189  AEKSLEKDAALFDEFVREN--------DCSSVQAMRAAEKETKAKIEKILEIRDLTTQIV 240
             E+ +        +F++E         +CSS    + AE+E KAK   + +IR+    + 
Sbjct: 983  MEEEILLLEDQNSKFIKEKKLMEDRIAECSS----QLAEEEEKAK--NLAKIRNKQEVM- 1035

Query: 241  NIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSE-----ASKES 295
                 IS  E+ LK  +  +  L K   K   E  + +    +   ++ E     A KE 
Sbjct: 1036 -----ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090

Query: 296  SVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESS 355
             +      +G   +G   ++         K  R LQ  ++        S +     +E  
Sbjct: 1091 EL------QGALARGDDETL---HKNNALKVVRELQA-QIAELQEDFESEKASRNKAEKQ 1140

Query: 356  GGDSRGSNSPIPPTQEDT-DSDGEEPQLYFTEPQQLLDVFRELEEQ---NLSLIQNSQET 411
              D       +    EDT D+   + +L     Q++ ++ + LEE+   + + IQ+ ++ 
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200

Query: 412  EKT-LEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYK 470
              T LEELS  L+  + R    + + KQ +       T  ++ A E+++  +V    E+K
Sbjct: 1201 HATALEELSEQLEQAK-RFKANLEKNKQGLE------TDNKELACEVKVLQQVKAESEHK 1253

Query: 471  GDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIE 530
              + D  ++ L+ KV +      G +    L   +  + ++++LD +   LE   +  I+
Sbjct: 1254 RKKLDAQVQELHAKVSE------GDRLRVEL--AEKASKLQNELDNVSTLLEEAEKKGIK 1305

Query: 531  QAERAKEKERRIRLREEKLQMQKILQEEHLQR 562
             A+ A   E +++        Q++LQEE  Q+
Sbjct: 1306 FAKDAASLESQLQ------DTQELLQEETRQK 1331



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 110/553 (19%), Positives = 214/553 (38%), Gaps = 105/553 (18%)

Query: 64   LLRDQERNKALSERQQQKTMRVHQKMT-YSSKVSAKHTSLRRQ-----LQLEDKQEDLE- 116
            ++ D E      E+ +Q+  +  +K+   ++ +  +   L+ Q     LQL  K+E+L+ 
Sbjct: 1035 MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQG 1094

Query: 117  --ARAEAE--HQ----RAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVK 168
              AR + E  H+    +  R+       L ++   E  + +   KQKR    L   L+  
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD---LSEELEAL 1151

Query: 169  RREIQ-RLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIE 227
            + E++  L+T A ++E R +R ++  E   AL +E   +N  + +Q MR        ++ 
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEE--TKNHEAQIQDMRQRHATALEELS 1209

Query: 228  KILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKE 287
            + LE             +  RF+  L+              K+ LE   K+ +   K  +
Sbjct: 1210 EQLE-------------QAKRFKANLE------------KNKQGLETDNKELACEVKVLQ 1244

Query: 288  VSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQ 347
              +A  E         K   +  +   + AK  +G +   R     +  +  + L +   
Sbjct: 1245 QVKAESEH--------KRKKLDAQVQELHAKVSEGDRL--RVELAEKASKLQNELDNVST 1294

Query: 348  GSQPSESSG----GDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLS 403
              + +E  G     D+    S +  TQE    +  +     +  +QL +    L+EQ   
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 404  LIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARV 463
              +  +  EK +  L   L  T+ ++D ++  ++         +   E  +  LE KA  
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414

Query: 464  FHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEH 523
            +          DKL ++ N                           ++ +LD+L  +L+H
Sbjct: 1415 Y----------DKLEKTKN--------------------------RLQQELDDLTVDLDH 1438

Query: 524  VPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTL-VCR 582
              QV     ++ K+ ++   L EEK    +  +E      R RA+AE ++K  + L + R
Sbjct: 1439 QRQVASNLEKKQKKFDQ--LLAEEKSISARYAEE------RDRAEAEAREKETKALSLAR 1490

Query: 583  SRPPAHRIKQQSE 595
            +   A   K++ E
Sbjct: 1491 ALEEALEAKEEFE 1503



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 95/492 (19%), Positives = 185/492 (37%), Gaps = 66/492 (13%)

Query: 116  EARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRL 175
            + +AE+EH+R   D    +L     K  E + +   + +K     LQ  LD     ++  
Sbjct: 1245 QVKAESEHKRKKLDAQVQEL---HAKVSEGDRLRVELAEKASK--LQNELDNVSTLLEEA 1299

Query: 176  ETLATKEEARLERAEKSLEKDAALFDEFVR------------ENDCSSVQAMRAAEKETK 223
            E    K        E  L+    L  E  R            E + +S+Q  +  E+E +
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359

Query: 224  AKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSP--KEWLEEQEKKHSF 281
              +EK  ++  L +Q+ + K ++     T++  +  K  L K +    + LEE+   +  
Sbjct: 1360 KNLEK--QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417

Query: 282  LKKAKE---------------VSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKP 326
            L+K K                  + +          D+    +   S+ +A+E    +  
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477

Query: 327  WRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTE 386
             R  +T  L  + + L    +  +  E      R     +  +++D   +          
Sbjct: 1478 AREKETKALSLARA-LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN---------- 1526

Query: 387  PQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQ---IRMDREVNQLKQWVTTM 443
                     ELE+   +L Q  +E    LEEL   L+ T+   +R++  +  +K      
Sbjct: 1527 -------VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERD 1579

Query: 444  MMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQE----A 499
            + +  ++ +    L +K       E + +++ + L   + K +++       Q E    A
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639

Query: 500  NLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIR-LREEKLQMQKILQEE 558
                ++ L  ++ Q+ +    LE     + E   ++KE E++++ L  E LQ    LQEE
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ----LQEE 1695

Query: 559  HLQRARARAQAE 570
                 RAR  AE
Sbjct: 1696 LASSERARRHAE 1707



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 117/576 (20%), Positives = 213/576 (36%), Gaps = 81/576 (14%)

Query: 12   NMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGP---DPSANPFHLS-GDVDFFLLRD 67
            N+  +K  LE+ N     + E    +Q +   EH     D      H    + D   +  
Sbjct: 1221 NLEKNKQGLETDN--KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVEL 1278

Query: 68   QERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDL--EARAEAEHQR 125
             E+   L       +  + +      K +    SL  QLQ  D QE L  E R +     
Sbjct: 1279 AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ--DTQELLQEETRQKLNLSS 1336

Query: 126  AFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYAL-DVKRREIQRLETLATKEEA 184
              R     K +L +++  E E        ++Q+  LQ  L D K++    L T+ + EEA
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393

Query: 185  RLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQI----- 239
            +     K L KDA    + + E          A +K  K K     E+ DLT  +     
Sbjct: 1394 K-----KKLLKDAEALSQRLEEKAL-------AYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441

Query: 240  --VNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEA--SKES 295
               N++ +  +F+  L   K       +   +   E +EK+   L  A+ + EA  +KE 
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 296  -------------SVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMR--LGRSPS 340
                          + S+  D G  +     S  A E Q        ++ MR  L     
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ--------VEEMRTQLEELED 1553

Query: 341  YLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQ 400
             L + +      E +    +        T+++ +   E+ +L   + ++L     +  +Q
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE--EKKRLLIKQVRELEAELEDERKQ 1611

Query: 401  NLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELK 460
                + + ++ E  L++L   ++      D  + QL++    M       +D   ELE +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM-------KDYQRELE-E 1663

Query: 461  ARVFH---FGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDEL 517
            AR      F + K  + +K L+SL  ++L +      +++             E + DEL
Sbjct: 1664 ARASRDEIFAQSK--ESEKKLKSLEAEILQLQEELASSERARRHA--------EQERDEL 1713

Query: 518  LENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQK 553
             + + +    K    +  +  E RI   EE+L+ ++
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 42/197 (21%), Positives = 79/197 (40%), Gaps = 8/197 (4%)

Query: 378  EEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIR---MDREVN 434
            EE  +   + Q   ++F E EE    L    QE E+ L +L   ++  + R   +  E  
Sbjct: 887  EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946

Query: 435  QLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTG 494
            +++  +  +   + +EE    +L+L+         K +++  LLE  N K +   +    
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK---- 1002

Query: 495  TQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKI 554
               E  +         E +  + L  + +  +V I   E   +KE + R   EK + +  
Sbjct: 1003 -LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061

Query: 555  LQEEHLQRARARAQAEI 571
             +   LQ   A  QA+I
Sbjct: 1062 GETTDLQDQIAELQAQI 1078



 Score = 34.3 bits (77), Expect = 0.34
 Identities = 90/519 (17%), Positives = 189/519 (36%), Gaps = 91/519 (17%)

Query: 67   DQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEA--------- 117
            D +  + ++   ++K  +  Q +     +SA++   R + + E ++++ +A         
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494

Query: 118  --RAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKR----QMFLLQYALDVKRRE 171
               A+ E +R  +        L   K+   +N+    K KR    Q+  ++  L+    E
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554

Query: 172  IQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKE---------- 221
            +Q  E    + E  ++  +   E+D    DE   E     ++ +R  E E          
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614

Query: 222  ---TKAKIEKILEIRDLTTQIV--------------NIKSEISRFEDTLKHYKVYKDFLY 264
               +K K+E  ++++DL  QI                +++++  ++  L+  +  +D ++
Sbjct: 1615 AVASKKKME--IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 265  KLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTK 324
              S     +E EKK   L+   E+ +  +E + +          + + +        G  
Sbjct: 1673 AQS-----KESEKKLKSLE--AEILQLQEELASSERARRHAEQERDELADEITNSASG-- 1723

Query: 325  KPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYF 384
                  ++  L       +   Q  +  E    +    N     T    D+   E     
Sbjct: 1724 ------KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 385  TEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMM 444
            +  Q+  +  ++LE QN  L    QE E  ++      K T   ++ ++ QL++     +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKS---KFKATISALEAKIGQLEE----QL 1830

Query: 445  MSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTV 504
                KE   A +L  +              +K L+ +  +V D  RH    +++      
Sbjct: 1831 EQEAKERAAANKLVRRT-------------EKKLKEIFMQVEDERRHADQYKEQMEKANA 1877

Query: 505  QMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIR 543
            +M      QL   LE  E       E+A RA    R+++
Sbjct: 1878 RM-----KQLKRQLEEAE-------EEATRANASRRKLQ 1904


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 123/635 (19%), Positives = 243/635 (38%), Gaps = 98/635 (15%)

Query: 3   EIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQAR-KNEEHGPDPSANPFHLSGDVD 61
           E  + +V KN+  +   L +      +  E+  K++A  + E++  D     F  +    
Sbjct: 233 EEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDN---- 288

Query: 62  FFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQ-LED--KQEDLEAR 118
             L+  ++  +    +    ++++  K T   +     T +R++LQ L++  KQ      
Sbjct: 289 --LIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTA 346

Query: 119 AEAE--HQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLE 176
            +AE   Q    +  T K+ L  +++V       Y K   ++ +       K  E    +
Sbjct: 347 QQAELIQQLQVLNMDTQKV-LRNQEDVHTAESISYQKLYNELHICFET--TKSNEAMLRQ 403

Query: 177 TLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLT 236
           ++   ++  L++     E++ A   E ++E+  + +   + ++ +  A++     +  L 
Sbjct: 404 SVTNLQDQLLQK-----EQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458

Query: 237 TQIVNIKSEISRFEDTLK--------HYKVYKDFLYK--------------------LSP 268
           T +V+ KSEI   ++ LK        +    K F  K                    LSP
Sbjct: 459 TLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSP 518

Query: 269 KEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWR 328
           K    + E+     K  +++    K   + S   D+      K            K+  +
Sbjct: 519 KSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR-----------KERLQ 567

Query: 329 FLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQ---EDTDSDGEEPQLYFT 385
            LQT       +Y +  +Q  Q  E SG           P Q   ED+D+   E   +  
Sbjct: 568 MLQT-------NYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR 620

Query: 386 EPQQLLDVFRELEEQ----------NLSLIQ--NSQETEKTLEELSHTLKHTQIRMDREV 433
           E Q+L+     LEE+          + + IQ  N    E+  E+L  + +  +++     
Sbjct: 621 ENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPE 680

Query: 434 NQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCT 493
              K+ +   +  +T+ E+     E ++R    G  K  +++  L+SL    L   +  T
Sbjct: 681 KNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSL----LKQQQEDT 736

Query: 494 GTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERR-----IRLREEK 548
            T+++      ++  II+   D   EN E   QVKI + E      RR       LR E 
Sbjct: 737 ETREK------ELEQIIKGSKDVEKENTE--LQVKISELETEVTSLRRQVAEANALRNEN 788

Query: 549 LQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRS 583
            ++   +++ H    RA+++    K R     C++
Sbjct: 789 EELINPMEKSHQSADRAKSEMATMKVRSGRYDCKT 823


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.125    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,991,964
Number of Sequences: 37866
Number of extensions: 1105127
Number of successful extensions: 9876
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 151
Number of HSP's successfully gapped in prelim test: 653
Number of HSP's that attempted gapping in prelim test: 6789
Number of HSP's gapped (non-prelim): 2992
length of query: 611
length of database: 18,247,518
effective HSP length: 108
effective length of query: 503
effective length of database: 14,157,990
effective search space: 7121468970
effective search space used: 7121468970
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.