Guide to the Human Genome
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Search of human proteins with 216548091

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|216548091 leucine zipper protein 1 [Homo sapiens]
         (1076 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|216548091 leucine zipper protein 1 [Homo sapiens]                 2097   0.0  
gi|216548085 leucine zipper protein 1 [Homo sapiens]                 2097   0.0  
gi|31542634 filamin A interacting protein 1 [Homo sapiens]            322   9e-88
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...   259   1e-68
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom...   259   1e-68
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...   259   1e-68
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     94   9e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    91   6e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    90   1e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    90   1e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    90   1e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    90   1e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    90   1e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    85   3e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    85   3e-16
gi|16262452 cingulin [Homo sapiens]                                    83   1e-15
gi|45439327 periplakin [Homo sapiens]                                  83   1e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       82   3e-15
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                81   5e-15
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                81   5e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    81   6e-15
gi|112420968 coiled-coil domain containing 158 [Homo sapiens]          81   6e-15
gi|31982906 cingulin-like 1 [Homo sapiens]                             80   8e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    80   1e-14
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     80   1e-14
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  79   3e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         78   4e-14
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                 78   5e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    78   5e-14
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    78   5e-14

>gi|216548091 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 2097 bits (5434), Expect = 0.0
 Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)

Query: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
            MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS
Sbjct: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60

Query: 61   MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
            MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL
Sbjct: 61   MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
            EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA
Sbjct: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
            SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL
Sbjct: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240

Query: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
            RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT
Sbjct: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300

Query: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
            QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG
Sbjct: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360

Query: 361  EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
            EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ
Sbjct: 361  EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420

Query: 421  VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
            VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA
Sbjct: 421  VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480

Query: 481  AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
            AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG
Sbjct: 481  AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540

Query: 541  KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
            KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP
Sbjct: 541  KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600

Query: 601  VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
            VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD
Sbjct: 601  VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660

Query: 661  DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
            DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS
Sbjct: 661  DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720

Query: 721  VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
            VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK
Sbjct: 721  VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780

Query: 781  QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
            QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS
Sbjct: 781  QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840

Query: 841  PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
            PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR
Sbjct: 841  PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900

Query: 901  WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
            WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF
Sbjct: 901  WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960

Query: 961  SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
            SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH
Sbjct: 961  SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020

Query: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
            SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN
Sbjct: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076


>gi|216548085 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 2097 bits (5434), Expect = 0.0
 Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)

Query: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
            MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS
Sbjct: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60

Query: 61   MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
            MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL
Sbjct: 61   MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120

Query: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
            EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA
Sbjct: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180

Query: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
            SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL
Sbjct: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240

Query: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
            RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT
Sbjct: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300

Query: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
            QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG
Sbjct: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360

Query: 361  EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
            EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ
Sbjct: 361  EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420

Query: 421  VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
            VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA
Sbjct: 421  VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480

Query: 481  AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
            AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG
Sbjct: 481  AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540

Query: 541  KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
            KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP
Sbjct: 541  KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600

Query: 601  VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
            VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD
Sbjct: 601  VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660

Query: 661  DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
            DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS
Sbjct: 661  DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720

Query: 721  VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
            VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK
Sbjct: 721  VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780

Query: 781  QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
            QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS
Sbjct: 781  QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840

Query: 841  PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
            PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR
Sbjct: 841  PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900

Query: 901  WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
            WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF
Sbjct: 901  WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960

Query: 961  SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
            SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH
Sbjct: 961  SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020

Query: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
            SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN
Sbjct: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score =  322 bits (826), Expect = 9e-88
 Identities = 224/582 (38%), Positives = 320/582 (54%), Gaps = 68/582 (11%)

Query: 9   ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
           + + +R LR KL  L++R++ELEE  KNLQKAE+EL +L+DK+ + E  NSS++AE+E L
Sbjct: 324 QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENL 383

Query: 69  RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFS 128
           R+RVL +EGKDEEI + E  CR +++KL+EEE+ ++EL+ E+E+LQKRM+ELEKLEEAFS
Sbjct: 384 RKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFS 443

Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKS 188
           +SK++CTQL L+L +E+NLTK + +ELE+++ +VKELE SE RL+K E SL  +L KLKS
Sbjct: 444 KSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS 503

Query: 189 LTLSFVSERKYLNEKEKENEKLIKELTQ--KLEQNK----------------KMNRDYTR 230
            T+  V ERK + EK K+ E+ +  L +  K+EQ K                K+  +   
Sbjct: 504 FTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEE 563

Query: 231 NASNLER------NDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRN- 282
              NL R        L+ E+  SS L       K  LD +++VE E TR +S        
Sbjct: 564 KVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623

Query: 283 QEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE 342
            EDNK+K+L  EIE+LK +++  E +E +L K + + + L+  + +EQ+K   L+ QLEE
Sbjct: 624 PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE 683

Query: 343 IKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR--- 399
           IK QI K K +E GEV  ++A L  + R E  K R   +E    K    EL  +  +   
Sbjct: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQ 743

Query: 400 -----ERLRNREFALNNENYSLSNRQVS---------------SPSFTNRRA--AKASHM 437
                  L+ R     N+N ++    ++                PS   RR      +  
Sbjct: 744 LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTST 803

Query: 438 GVSTD--SGTQETKKTEDRFVPGSSQSEG-----------KKSREQPSVLSRYPPAAQEH 484
           GV TD  SG    ++T   F+  S Q E            KK  E+ SVL RYPPAA E 
Sbjct: 804 GVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANEL 863

Query: 485 S--KAWKGTSKPGTESGLKGKVEKTTRTFSDTTH-GSVPSDP 523
           +  K+W    +   E+G     EK  RT S   H G V   P
Sbjct: 864 TMRKSWIPWMRK-RENGPSITQEKGPRTNSSPGHPGEVVLSP 904



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 90/419 (21%), Positives = 182/419 (43%), Gaps = 65/419 (15%)

Query: 3   EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL----------------- 45
           +FT+  E    R  +   Q  + +  + +E  K L K  DEL+                 
Sbjct: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHI 258

Query: 46  -----------DLQDKVIQAEGSNSSMLAEIEVLRQRVLRIE-GKDEEIKRAEDLCRLMK 93
                      DL  K+ + E    ++ ++ +  RQ++L++E   + +  R       M 
Sbjct: 259 EQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMN 318

Query: 94  EKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISS 153
            KL  +E+  R+L+ ++  L +R+ ELE+  +   +++ +  +L   + +       + +
Sbjct: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMA 378

Query: 154 ELEMLRVKVKELESSEDRLDKTE---------------------------QSLASELEKL 186
           E+E LR +V E+E  ++ + KTE                           Q   SELEKL
Sbjct: 379 EVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKL 438

Query: 187 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGI 246
           +       SE   L+   ++ + L K+L  +LE  K   ++   + S LE+ +L ++D +
Sbjct: 439 EEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDL 498

Query: 247 ----SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQE-IEKLKTQ 301
               S T+   + R+    + +++++ E R      KN   E  KV D+ ++ IE+ K  
Sbjct: 499 TKLKSFTVMLVDERK----NMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKL 554

Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
           +K    +EE++  +  + ++L     SE+ K+  L+  ++ +K ++   +E+E     G
Sbjct: 555 LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 87/346 (25%), Positives = 149/346 (43%), Gaps = 48/346 (13%)

Query: 27  LDELEEATKNLQKAEDELLDL--QDKVIQA--EGSNSSMLAEIEVLRQRVLRIEGKDEEI 82
           +++ ++ T  L++  + L  L  Q+K  QA  E  N+  L ++            +DE +
Sbjct: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL------------RDELV 241

Query: 83  KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
           K       L+ E+    E L  + +   +  QK   E EKL+   S+SK D  +L     
Sbjct: 242 KLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV 301

Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
           +  +   + S E E +  K+   ES   +L      L   +E+L+             N+
Sbjct: 302 DFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEE-----------TNK 350

Query: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLD 262
             ++ E+ ++EL  K+ + +  N        NL +  L +E               G  +
Sbjct: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEME---------------GKDE 395

Query: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDL 322
            + + E++ R   E  K   +E++  K+L  E+EKL+ ++   E LEE   K KS+   L
Sbjct: 396 EITKTESQCR---ELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452

Query: 323 QDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSK 368
             N   E+N  K L ++LE +K ++   KELE  E   E A LS K
Sbjct: 453 HLNLEKEKNLTKDLLNELEVVKSRV---KELECSESRLEKAELSLK 495



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 72/319 (22%), Positives = 130/319 (40%), Gaps = 32/319 (10%)

Query: 75  IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKND 133
           I G   E   +ED  +  K   +E++ +       ++R  K   E E K +++   SK D
Sbjct: 23  IIGNAGEKSLSEDAKKKKKSNRKEDDVMA---SGTVKRHLKTSGECERKTKKSLELSKED 79

Query: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELE----SSED----RLDKTEQSLASELEK 185
             QL   +  E    + +   L+  + K + LE    S+E     R+   +  LA E   
Sbjct: 80  LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSI 139

Query: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
            + +    +SE   L EK+KE  + + E     E+  +       N  +   + +   D 
Sbjct: 140 GEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDD 199

Query: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT----Q 301
            ++ L  +  R K      K +E E   ++  EK   +  NK++D   E+ KLK+     
Sbjct: 200 FTNLLEQERERLK------KLLEQEKAYQARKEKENAKRLNKLRD---ELVKLKSFALML 250

Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE-----IKLQIKKQKELENG 356
           +   +   E+L     K  DL      E+ K K + S+ +E     +KL++  + +    
Sbjct: 251 VDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRF 310

Query: 357 EVEGED--AFLSSKGRHER 373
             E E+  A L+++  H R
Sbjct: 311 SQEHEEMNAKLANQESHNR 329


>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
           sapiens]
          Length = 1133

 Score =  259 bits (662), Expect = 1e-68
 Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)

Query: 1   MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
           MA+ T+  E + +R L+ KL +LSR++DELEE  ++L+KAE+EL D+++K+ + E  N+ 
Sbjct: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367

Query: 61  MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
           ++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E   +++ K E+E+L KR+  L
Sbjct: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427

Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
           EKLE+AF++SK +C  L  +L +ER  TK++S ELE L+V++KELE+ E RL+KTE +L 
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487

Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
            +L KLK+LT+ FV ERK ++EK K+ E  ++  + +L  EQNK                
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547

Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
           K   D        T+   +L +N L+ E+   + L S+ +  K  L  L+ +E +  +NK
Sbjct: 548 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 606

Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
              +  +     +QE+NK+K+L+QE+E+LK ++K  +++E++L K + +   L+  Y +E
Sbjct: 607 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 666

Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
           ++K + L+ +LE +K+++ K K  E  E             HE+  F+    E + S H 
Sbjct: 667 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 715

Query: 390 AREL 393
           +RE+
Sbjct: 716 SREV 719



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
           KE  +++ L  +L+SL  R+ ELE     L+K E                  DE   + +
Sbjct: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509

Query: 50  KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
           K+ + E    +  ++++V + +V  +  K  EE KRA        E +  + KE      
Sbjct: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569

Query: 95  KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
           KL+ EE    +L S +  L+ R+  LE +E+ F ++K   D  +   +L++E N  K++S
Sbjct: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629

Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
            E+E L++K+K++++ ED L KTE     E E L         ER+Y NE++K     K 
Sbjct: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676

Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
           ++ +  +L + K   +  T +   L +  L+ E+  S  L  +    K  +      E+ 
Sbjct: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735

Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
                 + S  +K  NQ++N+ +DL +EIE L  +++ +    + L+   +         
Sbjct: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795

Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
            S++ + + + ++  + K  I  ++ + NG++  E
Sbjct: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)

Query: 3   EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
           EF    E    R  +   Q +  + ++ +E  K +   ++EL  L+   +        + 
Sbjct: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250

Query: 63  AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
           A++ + RQ++  L    K+   K A     L + +++EEE     L+ E           
Sbjct: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294

Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
             L+   ++   D   +   L  E +  +++  +L  L  ++ ELE +   L K E+ L 
Sbjct: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352

Query: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
              EK+         +       RK + + E ++E+LIK   Q  + NK++ R+      
Sbjct: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406

Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
            L+  D ++E         K S+R   L+ L+   N+++ +  + K N  +E    K L+
Sbjct: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459

Query: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
           QE+E LK +IK  E++E  L+K    +K     L+   +   ++ K ++ +L+  K + K
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517

Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
            Q      +VE       ++   E TK R   S+  V +   +  S   +R+ L+N+  A
Sbjct: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573

Query: 409 LNNENYSLSNR 419
              +   L +R
Sbjct: 574 EEEKGNDLLSR 584



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)

Query: 83  KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
           K  E   R++ + L  E++  + +    E  +K    +EK +E           +CL   
Sbjct: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198

Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
           E   L K I  E       +K  E  E   +K   +L  EL KLKS  L  V E++ L  
Sbjct: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251

Query: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
           +     + I+ELT   ++            ++  +  TR    L+    +    +D I +
Sbjct: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311

Query: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
            L +++S+ +     L  +  +     E  ++  + + +++D+ +              E
Sbjct: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371

Query: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
           +E+L+ ++   E  +EEL KM+ +  DL      E  ++K    ++E++  +I   ++LE
Sbjct: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431

Query: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
           +   + +    S K   E+ +         +     R    +    RL   EF L  +  
Sbjct: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489

Query: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
            L+  +  +  F + R              +++ KKTED+    SSQ + ++++
Sbjct: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 5   TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
           T  K  A+S  L+ +   ++   ++L E TK   K++ ++            DL++K+  
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573

Query: 54  AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
            E   + +L+ + +L+ R+  +E  +++    K  +D  +     L +E N  +EL  E+
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632

Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
           ERL+ ++ +++ +E+   +++++   L      ER+  + +S ELE +++++ + + +E 
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692

Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
                EQ L   L++ ++ +     E   L EK  E    E LI         L +KL Q
Sbjct: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752

Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
            +  NRD  R   NL +   R      S  PS   RR
Sbjct: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789


>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
           sapiens]
          Length = 893

 Score =  259 bits (662), Expect = 1e-68
 Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)

Query: 1   MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
           MA+ T+  E + +R L+ KL +LSR++DELEE  ++L+KAE+EL D+++K+ + E  N+ 
Sbjct: 70  MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127

Query: 61  MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
           ++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E   +++ K E+E+L KR+  L
Sbjct: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187

Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
           EKLE+AF++SK +C  L  +L +ER  TK++S ELE L+V++KELE+ E RL+KTE +L 
Sbjct: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 247

Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
            +L KLK+LT+ FV ERK ++EK K+ E  ++  + +L  EQNK                
Sbjct: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 307

Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
           K   D        T+   +L +N L+ E+   + L S+ +  K  L  L+ +E +  +NK
Sbjct: 308 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 366

Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
              +  +     +QE+NK+K+L+QE+E+LK ++K  +++E++L K + +   L+  Y +E
Sbjct: 367 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 426

Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
           ++K + L+ +LE +K+++ K K  E  E             HE+  F+    E + S H 
Sbjct: 427 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 475

Query: 390 AREL 393
           +RE+
Sbjct: 476 SREV 479



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
           KE  +++ L  +L+SL  R+ ELE     L+K E                  DE   + +
Sbjct: 210 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269

Query: 50  KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
           K+ + E    +  ++++V + +V  +  K  EE KRA        E +  + KE      
Sbjct: 270 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 329

Query: 95  KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
           KL+ EE    +L S +  L+ R+  LE +E+ F ++K   D  +   +L++E N  K++S
Sbjct: 330 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 389

Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
            E+E L++K+K++++ ED L KTE     E E L         ER+Y NE++K     K 
Sbjct: 390 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 436

Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
           ++ +  +L + K   +  T +   L +  L+ E+  S  L  +    K  +      E+ 
Sbjct: 437 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 495

Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
                 + S  +K  NQ++N+ +DL +EIE L  +++ +    + L+   +         
Sbjct: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 555

Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
            S++ + + + ++  + K  I  ++ + NG++  E
Sbjct: 556 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 590



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 5   TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
           T  K  A+S  L+ +   ++   ++L E TK   K++ ++            DL++K+  
Sbjct: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333

Query: 54  AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
            E   + +L+ + +L+ R+  +E  +++    K  +D  +     L +E N  +EL  E+
Sbjct: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 392

Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
           ERL+ ++ +++ +E+   +++++   L      ER+  + +S ELE +++++ + + +E 
Sbjct: 393 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452

Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
                EQ L   L++ ++ +     E   L EK  E    E LI         L +KL Q
Sbjct: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512

Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
            +  NRD  R   NL +   R      S  PS   RR
Sbjct: 513 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 549



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 82/360 (22%), Positives = 159/360 (44%), Gaps = 39/360 (10%)

Query: 80  EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK--------LEEAFSRSK 131
           +E +R      L ++K++E     +E  +++   + R+ E E+        L+   ++  
Sbjct: 4   DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63

Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK---- 187
            D   +   L  E +  +++  +L  L  ++ ELE +   L K E+ L    EK+     
Sbjct: 64  QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123

Query: 188 ---SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
               +       RK + + E ++E+LIK   Q  + NK++ R+       L+  D ++E 
Sbjct: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------TLQSKDFKLE- 176

Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLNQEIEKLKTQIK 303
                   K S+R   L+ L+   N+++ +  + K N  +E    K L+QE+E LK +IK
Sbjct: 177 ------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230

Query: 304 HFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
             E++E  L+K    +K     L+   +   ++ K ++ +L+  K + K Q      +VE
Sbjct: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDKLQAASSQLQVE 288

Query: 360 GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNR 419
                  ++   E TK R   S+  V +   +  S   +R+ L+N+  A   +   L +R
Sbjct: 289 QNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKAEEEKGNDLLSR 344



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 69/342 (20%), Positives = 136/342 (39%), Gaps = 71/342 (20%)

Query: 136 QLCLSLNEERNLT---KKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
           QL L   + + LT   K+  ++L +   +V+E E    RL+K  Q+  ++  + +   ++
Sbjct: 12  QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 71

Query: 193 FVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPS 252
            ++     N + ++    +     +LE+  +  R       +++    + E G +  +  
Sbjct: 72  KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 131

Query: 253 KESRRKGGLDY------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
            E  RK  LD       L ++E + R+ +   K   +E  + KD   E+EKL  +I   E
Sbjct: 132 VEELRKRVLDMEGKDEELIKMEEQCRDLN---KRLERETLQSKDFKLEVEKLSKRIMALE 188

Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS 366
            LE+   K K +   L+ N   E+   K L+ +LE +K++IK+ + +E+           
Sbjct: 189 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES----------- 237

Query: 367 SKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSF 426
                                             RL   EF L  +   L+  +  +  F
Sbjct: 238 ----------------------------------RLEKTEFTLKED---LTKLKTLTVMF 260

Query: 427 TNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
            + R   +           ++ KKTED+    SSQ + ++++
Sbjct: 261 VDERKTMS-----------EKLKKTEDKLQAASSQLQVEQNK 291


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
           sapiens]
          Length = 1135

 Score =  259 bits (662), Expect = 1e-68
 Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)

Query: 1   MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
           MA+ T+  E + +R L+ KL +LSR++DELEE  ++L+KAE+EL D+++K+ + E  N+ 
Sbjct: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367

Query: 61  MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
           ++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E   +++ K E+E+L KR+  L
Sbjct: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427

Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
           EKLE+AF++SK +C  L  +L +ER  TK++S ELE L+V++KELE+ E RL+KTE +L 
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487

Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
            +L KLK+LT+ FV ERK ++EK K+ E  ++  + +L  EQNK                
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547

Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
           K   D        T+   +L +N L+ E+   + L S+ +  K  L  L+ +E +  +NK
Sbjct: 548 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 606

Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
              +  +     +QE+NK+K+L+QE+E+LK ++K  +++E++L K + +   L+  Y +E
Sbjct: 607 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 666

Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
           ++K + L+ +LE +K+++ K K  E  E             HE+  F+    E + S H 
Sbjct: 667 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 715

Query: 390 AREL 393
           +RE+
Sbjct: 716 SREV 719



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
           KE  +++ L  +L+SL  R+ ELE     L+K E                  DE   + +
Sbjct: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509

Query: 50  KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
           K+ + E    +  ++++V + +V  +  K  EE KRA        E +  + KE      
Sbjct: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569

Query: 95  KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
           KL+ EE    +L S +  L+ R+  LE +E+ F ++K   D  +   +L++E N  K++S
Sbjct: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629

Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
            E+E L++K+K++++ ED L KTE     E E L         ER+Y NE++K     K 
Sbjct: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676

Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
           ++ +  +L + K   +  T +   L +  L+ E+  S  L  +    K  +      E+ 
Sbjct: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735

Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
                 + S  +K  NQ++N+ +DL +EIE L  +++ +    + L+   +         
Sbjct: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795

Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
            S++ + + + ++  + K  I  ++ + NG++  E
Sbjct: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)

Query: 3   EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
           EF    E    R  +   Q +  + ++ +E  K +   ++EL  L+   +        + 
Sbjct: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250

Query: 63  AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
           A++ + RQ++  L    K+   K A     L + +++EEE     L+ E           
Sbjct: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294

Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
             L+   ++   D   +   L  E +  +++  +L  L  ++ ELE +   L K E+ L 
Sbjct: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352

Query: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
              EK+         +       RK + + E ++E+LIK   Q  + NK++ R+      
Sbjct: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406

Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
            L+  D ++E         K S+R   L+ L+   N+++ +  + K N  +E    K L+
Sbjct: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459

Query: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
           QE+E LK +IK  E++E  L+K    +K     L+   +   ++ K ++ +L+  K + K
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517

Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
            Q      +VE       ++   E TK R   S+  V +   +  S   +R+ L+N+  A
Sbjct: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573

Query: 409 LNNENYSLSNR 419
              +   L +R
Sbjct: 574 EEEKGNDLLSR 584



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)

Query: 83  KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
           K  E   R++ + L  E++  + +    E  +K    +EK +E           +CL   
Sbjct: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198

Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
           E   L K I  E       +K  E  E   +K   +L  EL KLKS  L  V E++ L  
Sbjct: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251

Query: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
           +     + I+ELT   ++            ++  +  TR    L+    +    +D I +
Sbjct: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311

Query: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
            L +++S+ +     L  +  +     E  ++  + + +++D+ +              E
Sbjct: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371

Query: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
           +E+L+ ++   E  +EEL KM+ +  DL      E  ++K    ++E++  +I   ++LE
Sbjct: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431

Query: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
           +   + +    S K   E+ +         +     R    +    RL   EF L  +  
Sbjct: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489

Query: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
            L+  +  +  F + R              +++ KKTED+    SSQ + ++++
Sbjct: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)

Query: 5   TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
           T  K  A+S  L+ +   ++   ++L E TK   K++ ++            DL++K+  
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573

Query: 54  AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
            E   + +L+ + +L+ R+  +E  +++    K  +D  +     L +E N  +EL  E+
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632

Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
           ERL+ ++ +++ +E+   +++++   L      ER+  + +S ELE +++++ + + +E 
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692

Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
                EQ L   L++ ++ +     E   L EK  E    E LI         L +KL Q
Sbjct: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752

Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
            +  NRD  R   NL +   R      S  PS   RR
Sbjct: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 93.6 bits (231), Expect = 9e-19
 Identities = 119/502 (23%), Positives = 215/502 (42%), Gaps = 99/502 (19%)

Query: 16   LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
            +R K  +   RL E+E     L     E L LQ++ +QAE   + + AE E LR R   +
Sbjct: 857  VREKQLAAENRLTEMETLQSQLMA---EKLQLQEQ-LQAE---TELCAEAEELRAR---L 906

Query: 76   EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
              K +E+   E++C  ++ ++EEEE   + L++E +++Q+ + ELE+             
Sbjct: 907  TAKKQEL---EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE------------- 950

Query: 136  QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
                 L EE +  +K+  E      K+K+LE  +  L+     LA E + L+     F +
Sbjct: 951  ----QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 196  ERKYLNEKEK-------ENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS 248
                  EK K       ++E +I +L ++L + +K  ++  +    LE +   + D I+ 
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 249  ----------TLPSKE--------------SRRKGGLDYLKQVE---NETRNKSENEK-N 280
                       L  KE              +++   L  ++++E   +E +   E+E+ +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126

Query: 281  RNQEDNKVKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN---- 333
            RN+ + + +DL +E+E LKT+++      + ++EL+  + +  ++    L E+ K     
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186

Query: 334  ------------KLLASQLEE---IKLQIKKQK---ELENGEVEGE-DAFLSSKG--RHE 372
                        + LA QLE+   +K  ++K K   E E GE+  E    L  KG   H+
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246

Query: 373  RTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAA 432
            R K      E  V K    E       +++   +  L+N    LS     S   T   +A
Sbjct: 1247 RKKVEAQLQELQV-KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305

Query: 433  KASHMGVSTDSGTQETKKTEDR 454
              S +       TQE  + E+R
Sbjct: 1306 LESQL-----QDTQELLQEENR 1322



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 97/420 (23%), Positives = 184/420 (43%), Gaps = 83/420 (19%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            A  + ++  +Q L  +L+E E A + LQ      E +L  L+++ I  E  N  +  E +
Sbjct: 936  AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995

Query: 67   VLRQRVLRIEGK-DEEIKRAEDLCRL----------MKEKLEEEENLTRELKS------- 108
            +L  R+        EE ++++ L +L          ++E+L  EE   +EL+        
Sbjct: 996  LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055

Query: 109  -------EIERLQKRMAEL--------EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISS 153
                   +I  LQ ++AEL        E+L+ A +R + +  Q  ++L + R L  +IS 
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115

Query: 154  ELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSL---TLSFVSERKYLNEKEKENEKL 210
                L+  ++   +S ++ +K ++ L  ELE LK+    TL   + ++ L  K ++   +
Sbjct: 1116 ----LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171

Query: 211  IK--------------------------ELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
            +K                          EL ++LEQ K++  +  +    LE     + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231

Query: 245  GISSTLPSK---ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
             +   L  K   E +RK     L++++ +    +E E+ R +  +KV  L  E++ +   
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKF---NEGERVRTELADKVTKLQVELDNVTGL 1288

Query: 302  IKHFESLEEEL-KKMKSKNNDLQD--NYLSEQNKNKLLAS----QLEEIKLQIKKQKELE 354
            +   +S   +L K   +  + LQD    L E+N+ KL  S    Q+E+ K   ++Q E E
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 63/501 (12%)

Query: 2    AEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM 61
            +E    K  A  + L+ K     R   EL +    LQ   D +  L   + Q++  +S +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL---LSQSDSKSSKL 1299

Query: 62   LAEIEVLR------QRVLRIEGKDE-----EIKRAEDLCRLMKEKLEEEENLTRELKSEI 110
              +   L       Q +L+ E + +     ++K+ ED     +E+LEEEE     L+ +I
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359

Query: 111  ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
              L  ++A+++K        K + +  CL   EE  + +K+  +LE L  + +E  ++ D
Sbjct: 1360 ATLHAQVADMKK--------KMEDSVGCLETAEE--VKRKLQKDLEGLSQRHEEKVAAYD 1409

Query: 171  RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTR 230
            +L+KT+  L  EL+ L       + +  +  +     EK  K+  Q L + K ++  Y  
Sbjct: 1410 KLEKTKTRLQQELDDL-------LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462

Query: 231  NASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
                 E               ++E   K  L   + +E     K+E E+   Q   +++D
Sbjct: 1463 ERDRAEAE-------------AREKETKA-LSLARALEEAMEQKAELERLNKQFRTEMED 1508

Query: 291  LNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ 346
            L    + +   +   E    +LE+++++MK++  +L+D   + ++    L   L+ +K Q
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568

Query: 347  IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406
             ++  +  + + E +   L  + R    +      + S++    ++L        L++ E
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD-----LKDLE 1623

Query: 407  FALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGK- 465
              +++ N    NR  +       +A     M    D     T+ + +  +  + ++E K 
Sbjct: 1624 AHIDSAN---KNRDEAIKQLRKLQAQMKDCMRELDD-----TRASREEILAQAKENEKKL 1675

Query: 466  KSREQPSVLSRYPPAAQEHSK 486
            KS E   +  +   AA E +K
Sbjct: 1676 KSMEAEMIQLQEELAAAERAK 1696



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 61/262 (23%), Positives = 107/262 (40%), Gaps = 48/262 (18%)

Query: 27   LDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKD----EEI 82
            L + +E  K L+  E E++ LQ+++  AE +      E + L   +    GK     EE 
Sbjct: 1665 LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724

Query: 83   KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL-----------EKLEEAFSRSK 131
            +R E     ++E+LEEE+  T  +   +++   ++ ++           +K E A  + +
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784

Query: 132  NDCTQLCLSLNE-ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL----EKL 186
                +L + L E E  +  K  + +  L  K+ +LE   D   K  Q+   ++    +KL
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844

Query: 187  KSLTLSFVSERK---------------------YLNEKEKENE-------KLIKELTQKL 218
            K + L    ER+                      L E E+E +       KL +EL    
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904

Query: 219  EQNKKMNRDYTRNASNLERNDL 240
            E    MNR+ +   + L R DL
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDL 1926



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 73/383 (19%), Positives = 156/383 (40%), Gaps = 61/383 (15%)

Query: 19   KLQSLSRRLDE-LEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG 77
            +L+   R L++ +EE    L++ EDEL   +D  ++ E +  +M A+ E  R    R E 
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGRDEQ 1579

Query: 78   KDEEIKRAEDLCRLMKEKLEEE--------------ENLTRELKSEIERLQKRMAELEKL 123
             +E+ K+     R M+ +LE+E              E   ++L++ I+   K   E  K 
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639

Query: 124  EEAFSRSKNDCT-----------QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
                     DC            ++     E     K + +E+  L+ ++   E ++ + 
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699

Query: 173  DKTEQSLASELEKLKSLTLSFVSERKYLN----------EKEKENEKLIKELTQKLE-QN 221
             +    LA E+          + E++ L           E+E+ N +LI +  +K   Q 
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759

Query: 222  KKMNRDYTRNASN----------LERNDLRIEDGISSTLPSKESRRKGGLDYLK------ 265
             ++N D     S+          LER +  ++  +     + +S+ K  +  L+      
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819

Query: 266  --QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE----LKKMKSKN 319
              Q++NET+ +    K   + + K+KD+  +++  +   + ++   ++    LK++K + 
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879

Query: 320  NDLQDNYLSEQNKNKLLASQLEE 342
             + ++         + L  +LE+
Sbjct: 1880 EEAEEEAQRANASRRKLQRELED 1902



 Score = 37.4 bits (85), Expect = 0.077
 Identities = 38/175 (21%), Positives = 77/175 (44%), Gaps = 15/175 (8%)

Query: 29   ELEEATKN---LQKAEDELLDLQDKVIQAEGS-NSSMLAEIEVLRQRVLRIEGK-DEEIK 83
            E   A KN    Q+ E +  +L+ K+ + EG+  S   A I  L  ++ ++E + D E K
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828

Query: 84   RAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNE 143
              +  C+ ++          ++LK  + ++       E+ ++   ++     QL   L E
Sbjct: 1829 ERQAACKQVRRT-------EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881

Query: 144  ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
                 ++ ++    L+   +ELE + +  D   + ++S   KL+   L FV  R+
Sbjct: 1882 AEEEAQRANASRRKLQ---RELEDATETADAMNREVSSLKNKLRRGDLPFVVPRR 1933


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 101/405 (24%), Positives = 191/405 (47%), Gaps = 45/405 (11%)

Query: 6   SYKETASS-RHLRFKLQSLSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAEGSNSSML 62
           S KET+S    + F+ + + + L+  +E  +  ++ E+EL  L+ +++++Q + +N  + 
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654

Query: 63  AE-IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE---------EEENLTRELKSEIER 112
            E IE L Q    +E ++ ++K+  D  + +  +LE         +EENL  EL+  +E 
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVES 712

Query: 113 LQ---KRMAELE----KLEEAFSRSKNDCTQLCLSLNEERNL----------TKKISSEL 155
           L+    +MA+L+    +LE    + K     L  S  +   L           +++   L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772

Query: 156 EMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELT 215
           E    K+++LES    L+   Q+L   LE+LK  +       K     E+E  +L K+  
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832

Query: 216 QKLEQNKKMNRDYTRNASNLERNDLRIE--DGISSTLPSKESRRKGGLDYLKQVENETRN 273
           Q  ++NK++ +      + LE N+++I   +  + TL  +    K     LK++E E + 
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK- 891

Query: 274 KSENEKNRNQEDNKVKDLNQEI--EKLKTQIKH--FESLEEELKKM-KSKNNDLQDNYLS 328
             E  K    +   +  L +++  EKLKTQ  +   E L  EL+K+  +K   L D   +
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949

Query: 329 EQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
           + ++ KLL S+LE     +KK  E++  ++   +A L     + +
Sbjct: 950 DDSRYKLLESKLES---TLKKSLEIKEEKIAALEARLEESTNYNQ 991



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 104/441 (23%), Positives = 188/441 (42%), Gaps = 84/441 (19%)

Query: 5   TSYKETASSRHLRFKLQSL-SRRLDELEEATKNLQKAEDELLDLQD-------KVIQAEG 56
           TS    A  + L  ++  L S RL +LE   ++L K  +EL    D       K+++ E 
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498

Query: 57  SNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR-LMKEKLEEE-------ENLTRELK- 107
            N  +  ++E+L   +++   + + ++  ++L + LMKEK + E       EN  R++K 
Sbjct: 499 ENQRLSKKVEILENEIVQ---EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555

Query: 108 --SEIERLQK---------------RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
              E E L +               R+ ++EK  +    S  + +     +  E+   KK
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615

Query: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
                +    + +ELE+    L+K  + L  ++  LK       +  +  +E E+EN KL
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675

Query: 211 ------IKELTQKLEQNKKMNRDYTRNASNLERN------------DLRIEDGISSTLPS 252
                  K LT +LE  +K N         L RN             L++E   +  L S
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE---NKELES 732

Query: 253 KESRRKGGLDYLK----------------QVENETRNKSENEKNR--NQEDNKVKDLNQE 294
           ++ + K GL+ LK                 +EN+   K+    N+   Q +++++DL  E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792

Query: 295 -------IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
                  +E+LK   K  E LE+E K ++ + + L+ +    + +NK L  Q  EIK   
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTT 851

Query: 348 KKQKELENGEVEGEDAFLSSK 368
            ++  ++ G +E E+  LS +
Sbjct: 852 LEENNVKIGNLEKENKTLSKE 872



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 95/444 (21%), Positives = 191/444 (43%), Gaps = 101/444 (22%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEAT-------KNLQKAEDELLDLQDKVIQAE----- 55
           K T S +HL            EL +A        + L++  ++LLD + ++ Q E     
Sbjct: 241 KRTESRQHLSV----------ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290

Query: 56  --GSNSSMLA----------EIEVLRQRVLRIEGKDEEIK--------------RAEDL- 88
               N ++L+          E++ LR++ +R++  + E+               R E+L 
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350

Query: 89  -------------------CRLMKEKLEEEENLTRELKSEI-----------ERLQKRMA 118
                               R   +KL E E    +LK+++           +++++ M 
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410

Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQ 177
           E   LE A  +S ++   L   L +    ++   +  + L  +V EL SS   +L+   Q
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470

Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
           SL   +E+L++   S       + + EKEN++L K++ + LE      +   +N  NL +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV-EILENEIVQEKQSLQNCQNLSK 529

Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK---SENEKNRNQEDNKVKDLNQE 294
           + ++ +  +  T+ +     +  +  L+Q ENE  N+   S  ++++   + +VKD+ +E
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSLRQRSQISAEARVKDIEKE 588

Query: 295 IEKLKTQIKHFES-----------LEEELKKMKSKN---NDLQDNYLSEQNKNKLLASQL 340
            + L   IK   S           +++EL+  K K     +L++     + +N+LL  ++
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648

Query: 341 EEIKLQIKKQK--ELENGEVEGED 362
             +K+  +K +  E EN E+E E+
Sbjct: 649 TNLKITCEKIEALEQENSELEREN 672



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 65/333 (19%), Positives = 140/333 (42%), Gaps = 17/333 (5%)

Query: 35   KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
            K+L+  E+++  L+ ++ ++   N  +  E++ +++    ++ + +E +  +    +  E
Sbjct: 967  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026

Query: 95   KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSE 154
              + E   ++E   E+ +++ R+ E+E+        K         L  + N    + ++
Sbjct: 1027 DNKWERE-SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---NLQAQ 1082

Query: 155  LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEKENEKL 210
            +  L+ +   L+     L      L  E   L S + S +++   L    +  E ENE +
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142

Query: 211  IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
            IKE          + +D+ +     ER     E  IS     K + +        +VE+ 
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN------LEVEHR 1196

Query: 271  TRNKSENE--KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLS 328
                  N+  K + Q ++  K L  E EK+  + K+ E++  E KK+  +N+ L   Y  
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256

Query: 329  EQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
               + ++L +  + +K  +   K LE   +E E
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSK-LEQTRLEAE 1288



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 123/574 (21%), Positives = 221/574 (38%), Gaps = 91/574 (15%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDE 80
            +SL  +   L+ A KNL+    +L D  +++++ +G    +   ++V ++++L +E K+ 
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNH 1233

Query: 81   EIKRAE--DLC-------RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            E   AE   LC           + L+E E L  + K+    L     E  +LE  FS+ K
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293

Query: 132  NDCTQLCLS---LNEERNLTKKISSELEMLRVKVKELESSEDRLDKTE----QSLASELE 184
                QL ++   LN +  L  ++   LE         E +   LD+ +    Q+     +
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLE---------EENRHLLDQIQTLMLQNRTLLEQ 1344

Query: 185  KLKSLTLSFVSERKY---LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASN------- 234
             ++S  L  V +R+Y   LNE  ++ EKL +++   ++Q K  +    R   N       
Sbjct: 1345 NMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI---MDQYKFYDPSPPRRRGNWITLKMR 1401

Query: 235  ---LERNDLRIEDGISSTL-PSKESRRKGGLDYLKQVENETRNKSENEKNRNQ-----ED 285
                 + D+  E   S TL P++    +G L    Q   ++ +   N     Q     + 
Sbjct: 1402 KLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKS 1461

Query: 286  NKVKDLNQEIEKLKTQIKHFESLE-----------EELKKMKSKNNDL-------QDNYL 327
            + + DL Q +          E+LE           +EL  M      +          + 
Sbjct: 1462 STMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFR 1521

Query: 328  SEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSK 387
            S+Q  N    +  E+I  Q           V          G   RT      + AS+ +
Sbjct: 1522 SKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSG---RTSTSNSNNNASLHE 1578

Query: 388  HTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQE 447
              A  ++ Q + +   + EF+L +++ + S+   SSP    +R  ++S +     S T E
Sbjct: 1579 VKAGAVNNQSRPQSHSSGEFSLLHDHEAWSS-SGSSPIQYLKRQTRSSPVLQHKISETLE 1637

Query: 448  TKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKT 507
            ++    +   GS  SE          +       +E +K      K  ++  L  +V K+
Sbjct: 1638 SR--HHKIKTGSPGSE----------VVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKS 1685

Query: 508  TRTFSDTTHGSVPSDPLGRADKASDTSSETVFGK 541
                      SV SD LG+    S   + +V GK
Sbjct: 1686 L---------SVSSDFLGKDKPVSCGLARSVSGK 1710


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 100/404 (24%), Positives = 188/404 (46%), Gaps = 44/404 (10%)

Query: 6   SYKETASS-RHLRFKLQSLSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAEGSNSSML 62
           S KET+S    + F+ + + + L+  +E  +  ++ E+EL  L+ +++++Q + +N  + 
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654

Query: 63  AE-IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE---------EEENLTRELKSEIER 112
            E IE L Q    +E ++ ++K+  D  + +  +LE         +EENL  EL+  +E 
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVES 712

Query: 113 LQ---KRMAELE----KLEEAFSRSKNDCTQLCLSLNEERNL----------TKKISSEL 155
           L+    +MA+L+    +LE    + K     L  S  +   L           +++   L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772

Query: 156 EMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELT 215
           E    K+++LES    L+   Q+L   LE+LK  +       K     E+E  +L K+  
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832

Query: 216 QKLEQNKKMNRDYTRNASNLERNDLRIE--DGISSTLPSKESRRKGGLDYLKQVENETRN 273
           Q  ++NK++ +      + LE N+++I   +  + TL  +    K     LK++E E + 
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK- 891

Query: 274 KSENEKNRNQEDNKVKDLNQEI--EKLKTQIKH--FESLEEELKKMKSKNNDLQDNYLSE 329
             E  K    +   +  L +++  EKLKTQ  +   E L  EL+K+      L  +  S 
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949

Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
            ++ KLL S+LE     +KK  E++  ++   +A L     + +
Sbjct: 950 DDRYKLLESKLES---TLKKSLEIKEEKIAALEARLEESTNYNQ 990



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 104/441 (23%), Positives = 188/441 (42%), Gaps = 84/441 (19%)

Query: 5   TSYKETASSRHLRFKLQSL-SRRLDELEEATKNLQKAEDELLDLQD-------KVIQAEG 56
           TS    A  + L  ++  L S RL +LE   ++L K  +EL    D       K+++ E 
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498

Query: 57  SNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR-LMKEKLEEE-------ENLTRELK- 107
            N  +  ++E+L   +++   + + ++  ++L + LMKEK + E       EN  R++K 
Sbjct: 499 ENQRLSKKVEILENEIVQ---EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555

Query: 108 --SEIERLQK---------------RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
              E E L +               R+ ++EK  +    S  + +     +  E+   KK
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615

Query: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
                +    + +ELE+    L+K  + L  ++  LK       +  +  +E E+EN KL
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675

Query: 211 ------IKELTQKLEQNKKMNRDYTRNASNLERN------------DLRIEDGISSTLPS 252
                  K LT +LE  +K N         L RN             L++E   +  L S
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE---NKELES 732

Query: 253 KESRRKGGLDYLK----------------QVENETRNKSENEKNR--NQEDNKVKDLNQE 294
           ++ + K GL+ LK                 +EN+   K+    N+   Q +++++DL  E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792

Query: 295 -------IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
                  +E+LK   K  E LE+E K ++ + + L+ +    + +NK L  Q  EIK   
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTT 851

Query: 348 KKQKELENGEVEGEDAFLSSK 368
            ++  ++ G +E E+  LS +
Sbjct: 852 LEENNVKIGNLEKENKTLSKE 872



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 95/444 (21%), Positives = 191/444 (43%), Gaps = 101/444 (22%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEAT-------KNLQKAEDELLDLQDKVIQAE----- 55
           K T S +HL            EL +A        + L++  ++LLD + ++ Q E     
Sbjct: 241 KRTESRQHLSV----------ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290

Query: 56  --GSNSSMLA----------EIEVLRQRVLRIEGKDEEIK--------------RAEDL- 88
               N ++L+          E++ LR++ +R++  + E+               R E+L 
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350

Query: 89  -------------------CRLMKEKLEEEENLTRELKSEI-----------ERLQKRMA 118
                               R   +KL E E    +LK+++           +++++ M 
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410

Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQ 177
           E   LE A  +S ++   L   L +    ++   +  + L  +V EL SS   +L+   Q
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470

Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
           SL   +E+L++   S       + + EKEN++L K++ + LE      +   +N  NL +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV-EILENEIVQEKQSLQNCQNLSK 529

Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK---SENEKNRNQEDNKVKDLNQE 294
           + ++ +  +  T+ +     +  +  L+Q ENE  N+   S  ++++   + +VKD+ +E
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSLRQRSQISAEARVKDIEKE 588

Query: 295 IEKLKTQIKHFES-----------LEEELKKMKSKN---NDLQDNYLSEQNKNKLLASQL 340
            + L   IK   S           +++EL+  K K     +L++     + +N+LL  ++
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648

Query: 341 EEIKLQIKKQK--ELENGEVEGED 362
             +K+  +K +  E EN E+E E+
Sbjct: 649 TNLKITCEKIEALEQENSELEREN 672



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 65/333 (19%), Positives = 140/333 (42%), Gaps = 17/333 (5%)

Query: 35   KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
            K+L+  E+++  L+ ++ ++   N  +  E++ +++    ++ + +E +  +    +  E
Sbjct: 966  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025

Query: 95   KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSE 154
              + E   ++E   E+ +++ R+ E+E+        K         L  + N    + ++
Sbjct: 1026 DNKWERE-SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---NLQAQ 1081

Query: 155  LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEKENEKL 210
            +  L+ +   L+     L      L  E   L S + S +++   L    +  E ENE +
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141

Query: 211  IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
            IKE          + +D+ +     ER     E  IS     K + +        +VE+ 
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN------LEVEHR 1195

Query: 271  TRNKSENE--KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLS 328
                  N+  K + Q ++  K L  E EK+  + K+ E++  E KK+  +N+ L   Y  
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255

Query: 329  EQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
               + ++L +  + +K  +   K LE   +E E
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSK-LEQTRLEAE 1287



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 126/602 (20%), Positives = 229/602 (38%), Gaps = 79/602 (13%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDE 80
            +SL  +   L+ A KNL+    +L D  +++++ +G    +   ++V ++++L +E K+ 
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNH 1232

Query: 81   EIKRAE--DLC-------RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            E   AE   LC           + L+E E L  + K+    L     E  +LE  FS+ K
Sbjct: 1233 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1292

Query: 132  NDCTQLCLS---LNEERNLTKKISSELEMLRVKVKELESSEDRLDKTE----QSLASELE 184
                QL ++   LN +  L  ++   LE         E +   LD+ +    Q+     +
Sbjct: 1293 EQYQQLDITSTKLNNQCELLSQLKGNLE---------EENRHLLDQIQTLMLQNRTLLEQ 1343

Query: 185  KLKSLTLSFVSERKY---LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASN------- 234
             ++S  L  V +R+Y   LNE  ++ EKL +++   ++Q K  +    R   N       
Sbjct: 1344 NMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI---MDQYKFYDPSPPRRRGNWITLKMR 1400

Query: 235  ---LERNDLRIEDGISSTL-PSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
                 + D+  E   S TL P++    +G L    Q+ ++    S +  + + ED +   
Sbjct: 1401 KLIKSKKDINRERQKSLTLTPTRSDSSEGFL----QLPHQDSQDSSSVGSNSLEDGQTLG 1456

Query: 291  LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
              +       ++    +  ++  KMK+        Y    + N L+ S +    L  +  
Sbjct: 1457 TKKSSMVALKRLPFLRNRPKDKDKMKA-------CYRRSMSMNDLVQSMV----LAGQWT 1505

Query: 351  KELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALN 410
               EN EV   D   + K R E          A     TA   S  +     R+++   N
Sbjct: 1506 GSTENLEV--PDDISTGKRRKE--------LGAMAFSTTAINFSTVNSSAGFRSKQLVNN 1555

Query: 411  NENYS---LSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKS 467
             +  S   +S + VS  S T  R    +    S DSG   T  + +       ++    +
Sbjct: 1556 KDTTSFEDISPQGVSDDSSTGSRV--HASRPASLDSGRTSTSNSNNNASLHEVKAGAVNN 1613

Query: 468  REQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHG-SVPSDPLGR 526
            + +P   S    +     +AW  +     +      +++ TR+     H  S   +    
Sbjct: 1614 QSRPQSHSSGEFSLLHDHEAWSSSGSSPIQ-----YLKRQTRSSPVLQHKISETLESRHH 1668

Query: 527  ADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAAN 586
              K     SE V  ++     N     Q  +S     +  +  S   SS+ L K K  + 
Sbjct: 1669 KIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSC 1728

Query: 587  GL 588
            GL
Sbjct: 1729 GL 1730


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
            + +  + DEL++  +  QKAE+EL +L+ K  Q  E  N         + + AE E +R 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 910

Query: 71   RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
              +R+  K +E+   E++   M+ +LEEEE+  ++L++E +++ ++M +LE+   EE  +
Sbjct: 911  --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 129  RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
            R K     L L         KK+  E+ ++        KE +  E+R+     +LA E E
Sbjct: 966  RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 185  KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
            K K+LT       S +SE +   +KE+++ + +++L +KLE +     +   D     + 
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 235  LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
            L+    + E+ + + L   +   +++   L  ++++E    +  E+       RN+ + +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 288  VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
             +DL +E+E LKT+++      + ++EL+  + +   +    L E+ ++           
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200

Query: 334  -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
                 + L  QLE+ K + K   +     +E E+A L+ +      +  G   +    K 
Sbjct: 1201 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1254

Query: 389  TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
               E   Q  + +  + E A   LN++ + L N   S     N    KA  +     S +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 446  QETKKTED 453
             + + T++
Sbjct: 1315 SQLQDTQE 1322



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)

Query: 28   DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
            +E+E  T  L +AE + + L   V     S SS L + + L Q         EE ++  +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1333

Query: 88   LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
            +   +++  EE  +L  +L  E+E  Q     +  L    S SK        ++      
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 148  TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
             K+   E+E L  + +E  ++ D+L+KT+  L  EL+    L +   ++R+ ++  EK+ 
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1450

Query: 208  EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
             K  + L ++   + K   +  R    A   E   L +   +   L +KE   +      
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510

Query: 265  KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
             ++E+   +K +  KN ++ +   + L  ++E++KTQ+   E LE+EL+  +     L+ 
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1567

Query: 325  NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
            N   L  Q +  L A   +  + + + Q++L   E E ED     +     + K  G   
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627

Query: 382  EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
            +  +   +A     E   Q ++ + + ++F    E+   S  ++ + +  N + AK+
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
            K     R L  +L++L   L++  ++T   Q    K E E+  L+  + +   S+ + + 
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 64   EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
            E+     Q V  +  + E+ KRA+      K+ LE+E  +L  EL+   +  Q+   + +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
            KLE      ++ C+    +  E  +   K+ +E+E +   + E E    +L K   SL+S
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 182  EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            +L    E L+  T   ++    L + E+E   L  +L +++E  + + R  +     L  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 238  NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
            +  +++D  S+    +E +++    + K++EN T+         +K E  KNR Q+  D+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 287  KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
             V DL+   Q +  L+ + + F+ L  E K + SK  D +D   +E    + K   LA  
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 340  LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
            LEE  L+ K++ E  N  ++ E +  +SSK
Sbjct: 1492 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1520



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 113/515 (21%), Positives = 205/515 (39%), Gaps = 80/515 (15%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
            A +R    K  SL+R L+E  EA + L+      KAE E L     D+   V + E S  
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535

Query: 60   SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
            ++  ++E ++    ++E  ++E++  ED       KL  E N+ + LK + ER LQ R  
Sbjct: 1536 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1585

Query: 119  ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
            + E+      R  ++       L +ER      ++  + L   +K+LE   D   K  + 
Sbjct: 1586 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642

Query: 179  LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
               +L KL++    F  E       R  +    KENEK  K L   L Q ++     +  
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 230  RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
            R  ++LE+ +L  E  ++S+L  + + +        ++        E + N     ++V+
Sbjct: 1703 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 290  DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
               Q+ E+L  ++    S           LE + K+++SK ++++    + ++K K   +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1817

Query: 339  QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR----------HERTKFRGHGSEASVSKH 388
             LE    Q+++Q E E  E +     L  K +           ER     +  +A     
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 389  TARELSPQ-----------HKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
              ++L  Q           +   R   RE     E+     R+V++     RR  + S +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937

Query: 438  G---------VSTDSGTQETKKTEDRFVPGSSQSE 463
                      +    G++E   T D    G+  SE
Sbjct: 1938 PSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1972



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            +L++  ++EE++  ED  +  KE+ ++ EN  +EL+ +  +L +    L++  +A +   
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
             +  ++ + L  ++   ++I  E+E        LE  EDR     Q L +E +K+    L
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 953

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
                  + L E+E   +KL  E      + KK+             +++ + D  ++ L 
Sbjct: 954  DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 997

Query: 252  SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
            SKE  RK   + +  +      + E  KN  +  NK + +  E+E +LK + K  + LE+
Sbjct: 998  SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 311  ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
              +K++   +D  +           L +Q+ E+K+Q+ KK++EL+      +D       
Sbjct: 1056 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108

Query: 370  RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
              ++ +   GH S+      S+  AR  + + KR+     E AL  E   L +   S+ +
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1164

Query: 426  FTNRRAAKASHMGVSTDSGTQETKKTE 452
                RA +   + V   +  +ET+  E
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHE 1191


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
            + +  + DEL++  +  QKAE+EL +L+ K  Q  E  N         + + AE E +R 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 917

Query: 71   RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
              +R+  K +E+   E++   M+ +LEEEE+  ++L++E +++ ++M +LE+   EE  +
Sbjct: 918  --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 129  RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
            R K     L L         KK+  E+ ++        KE +  E+R+     +LA E E
Sbjct: 973  RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 185  KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
            K K+LT       S +SE +   +KE+++ + +++L +KLE +     +   D     + 
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 235  LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
            L+    + E+ + + L   +   +++   L  ++++E    +  E+       RN+ + +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 288  VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
             +DL +E+E LKT+++      + ++EL+  + +   +    L E+ ++           
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207

Query: 334  -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
                 + L  QLE+ K + K   +     +E E+A L+ +      +  G   +    K 
Sbjct: 1208 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1261

Query: 389  TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
               E   Q  + +  + E A   LN++ + L N   S     N    KA  +     S +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 446  QETKKTED 453
             + + T++
Sbjct: 1322 SQLQDTQE 1329



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)

Query: 28   DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
            +E+E  T  L +AE + + L   V     S SS L + + L Q         EE ++  +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1340

Query: 88   LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
            +   +++  EE  +L  +L  E+E  Q     +  L    S SK        ++      
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 148  TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
             K+   E+E L  + +E  ++ D+L+KT+  L  EL+    L +   ++R+ ++  EK+ 
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1457

Query: 208  EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
             K  + L ++   + K   +  R    A   E   L +   +   L +KE   +      
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517

Query: 265  KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
             ++E+   +K +  KN ++ +   + L  ++E++KTQ+   E LE+EL+  +     L+ 
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1574

Query: 325  NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
            N   L  Q +  L A   +  + + + Q++L   E E ED     +     + K  G   
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634

Query: 382  EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
            +  +   +A     E   Q ++ + + ++F    E+   S  ++ + +  N + AK+
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
            K     R L  +L++L   L++  ++T   Q    K E E+  L+  + +   S+ + + 
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 64   EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
            E+     Q V  +  + E+ KRA+      K+ LE+E  +L  EL+   +  Q+   + +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
            KLE      ++ C+    +  E  +   K+ +E+E +   + E E    +L K   SL+S
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 182  EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            +L    E L+  T   ++    L + E+E   L  +L +++E  + + R  +     L  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 238  NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
            +  +++D  S+    +E +++    + K++EN T+         +K E  KNR Q+  D+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 287  KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
             V DL+   Q +  L+ + + F+ L  E K + SK  D +D   +E    + K   LA  
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 340  LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
            LEE  L+ K++ E  N  ++ E +  +SSK
Sbjct: 1499 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1527



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 113/515 (21%), Positives = 205/515 (39%), Gaps = 80/515 (15%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
            A +R    K  SL+R L+E  EA + L+      KAE E L     D+   V + E S  
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542

Query: 60   SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
            ++  ++E ++    ++E  ++E++  ED       KL  E N+ + LK + ER LQ R  
Sbjct: 1543 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1592

Query: 119  ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
            + E+      R  ++       L +ER      ++  + L   +K+LE   D   K  + 
Sbjct: 1593 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649

Query: 179  LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
               +L KL++    F  E       R  +    KENEK  K L   L Q ++     +  
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 230  RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
            R  ++LE+ +L  E  ++S+L  + + +        ++        E + N     ++V+
Sbjct: 1710 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 290  DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
               Q+ E+L  ++    S           LE + K+++SK ++++    + ++K K   +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1824

Query: 339  QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR----------HERTKFRGHGSEASVSKH 388
             LE    Q+++Q E E  E +     L  K +           ER     +  +A     
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 389  TARELSPQ-----------HKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
              ++L  Q           +   R   RE     E+     R+V++     RR  + S +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1944

Query: 438  G---------VSTDSGTQETKKTEDRFVPGSSQSE 463
                      +    G++E   T D    G+  SE
Sbjct: 1945 PSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1979



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            +L++  ++EE++  ED  +  KE+ ++ EN  +EL+ +  +L +    L++  +A +   
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
             +  ++ + L  ++   ++I  E+E        LE  EDR     Q L +E +K+    L
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 960

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
                  + L E+E   +KL  E      + KK+             +++ + D  ++ L 
Sbjct: 961  DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 1004

Query: 252  SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
            SKE  RK   + +  +      + E  KN  +  NK + +  E+E +LK + K  + LE+
Sbjct: 1005 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 311  ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
              +K++   +D  +           L +Q+ E+K+Q+ KK++EL+      +D       
Sbjct: 1063 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115

Query: 370  RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
              ++ +   GH S+      S+  AR  + + KR+     E AL  E   L +   S+ +
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1171

Query: 426  FTNRRAAKASHMGVSTDSGTQETKKTE 452
                RA +   + V   +  +ET+  E
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHE 1198


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
            + +  + DEL++  +  QKAE+EL +L+ K  Q  E  N         + + AE E +R 
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 917

Query: 71   RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
              +R+  K +E+   E++   M+ +LEEEE+  ++L++E +++ ++M +LE+   EE  +
Sbjct: 918  --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972

Query: 129  RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
            R K     L L         KK+  E+ ++        KE +  E+R+     +LA E E
Sbjct: 973  RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 185  KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
            K K+LT       S +SE +   +KE+++ + +++L +KLE +     +   D     + 
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 235  LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
            L+    + E+ + + L   +   +++   L  ++++E    +  E+       RN+ + +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 288  VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
             +DL +E+E LKT+++      + ++EL+  + +   +    L E+ ++           
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207

Query: 334  -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
                 + L  QLE+ K + K   +     +E E+A L+ +      +  G   +    K 
Sbjct: 1208 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1261

Query: 389  TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
               E   Q  + +  + E A   LN++ + L N   S     N    KA  +     S +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321

Query: 446  QETKKTED 453
             + + T++
Sbjct: 1322 SQLQDTQE 1329



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)

Query: 28   DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
            +E+E  T  L +AE + + L   V     S SS L + + L Q         EE ++  +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1340

Query: 88   LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
            +   +++  EE  +L  +L  E+E  Q     +  L    S SK        ++      
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400

Query: 148  TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
             K+   E+E L  + +E  ++ D+L+KT+  L  EL+    L +   ++R+ ++  EK+ 
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1457

Query: 208  EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
             K  + L ++   + K   +  R    A   E   L +   +   L +KE   +      
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517

Query: 265  KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
             ++E+   +K +  KN ++ +   + L  ++E++KTQ+   E LE+EL+  +     L+ 
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1574

Query: 325  NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
            N   L  Q +  L A   +  + + + Q++L   E E ED     +     + K  G   
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634

Query: 382  EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
            +  +   +A     E   Q ++ + + ++F    E+   S  ++ + +  N + AK+
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
            K     R L  +L++L   L++  ++T   Q    K E E+  L+  + +   S+ + + 
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202

Query: 64   EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
            E+     Q V  +  + E+ KRA+      K+ LE+E  +L  EL+   +  Q+   + +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
            KLE      ++ C+    +  E  +   K+ +E+E +   + E E    +L K   SL+S
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 182  EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            +L    E L+  T   ++    L + E+E   L  +L +++E  + + R  +     L  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382

Query: 238  NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
            +  +++D  S+    +E +++    + K++EN T+         +K E  KNR Q+  D+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 287  KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
             V DL+   Q +  L+ + + F+ L  E K + SK  D +D   +E    + K   LA  
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498

Query: 340  LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
            LEE  L+ K++ E  N  ++ E +  +SSK
Sbjct: 1499 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1527



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 92/392 (23%), Positives = 169/392 (43%), Gaps = 50/392 (12%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
            A +R    K  SL+R L+E  EA + L+      KAE E L     D+   V + E S  
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542

Query: 60   SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
            ++  ++E ++    ++E  ++E++  ED       KL  E N+ + LK + ER LQ R  
Sbjct: 1543 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1592

Query: 119  ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
            + E+      R  ++       L +ER      ++  + L   +K+LE   D   K  + 
Sbjct: 1593 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649

Query: 179  LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
               +L KL++    F  E       R  +    KENEK  K L   L Q ++     +  
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 230  RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
            R  ++LE+ +L  E  ++S+L  + + +        ++        E + N     ++V+
Sbjct: 1710 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 290  DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
               Q+ E+L  ++    S           LE + K+++SK ++++    + ++K K   +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1824

Query: 339  QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
             LE    Q+++Q E E  E +     L  K +
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 77/398 (19%), Positives = 168/398 (42%), Gaps = 60/398 (15%)

Query: 19   KLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
            +L+   R L+ ++EE    L++ EDEL   +D  ++ E +  ++  + E           
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 67   ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE--------EEENLTRELKSEIERLQ 114
                 L++++   E + E+ ++   L    K+KLE        + ++  +  +  I++L+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 115  KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDK 174
            K  A+++  +     ++    ++  +  E     K + ++L  L+  +   E +  + D 
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715

Query: 175  TEQSLASELEKLKSLTLSFVSERKYLN------EKEKENEK--------LIKELTQKLEQ 220
             ++ LA EL    S   +   E++ L       E+E E E+         +++ TQ+ EQ
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775

Query: 221  --------------NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
                          N+   +   R    L      +E  + S   S  +  +  +  L+ 
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835

Query: 266  QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNNDLQD 324
            QVE E R K    K+  Q+D K+K++  ++E  +   + + E  E+   ++K     L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 325  NYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
               +E+   ++ A++    KLQ +  +  E+ E  G +
Sbjct: 1896 ---AEEESQRINANRR---KLQRELDEATESNEAMGRE 1927



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            +L++  ++EE++  ED  +  KE+ ++ EN  +EL+ +  +L +    L++  +A +   
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
             +  ++ + L  ++   ++I  E+E        LE  EDR     Q L +E +K+    L
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 960

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
                  + L E+E   +KL  E      + KK+             +++ + D  ++ L 
Sbjct: 961  DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 1004

Query: 252  SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
            SKE  RK   + +  +      + E  KN  +  NK + +  E+E +LK + K  + LE+
Sbjct: 1005 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 311  ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
              +K++   +D  +           L +Q+ E+K+Q+ KK++EL+      +D       
Sbjct: 1063 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115

Query: 370  RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
              ++ +   GH S+      S+  AR  + + KR+     E AL  E   L +   S+ +
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1171

Query: 426  FTNRRAAKASHMGVSTDSGTQETKKTE 452
                RA +   + V   +  +ET+  E
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHE 1198



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 66/321 (20%), Positives = 141/321 (43%), Gaps = 26/321 (8%)

Query: 11   ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            A+ + L   L+ L  + D      EEA K L+K + ++ D Q ++  A  S   + A  +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 67   VLRQRVLRIEGKDEEIKRAEDLC---RLMKEKLEEEENLTRELKSEIE----------RL 113
               ++   +E    +++  EDL    R  K+   E+E L  EL S +           RL
Sbjct: 1684 ENEKKAKSLEADLMQLQ--EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

Query: 114  QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD 173
            + R+A+LE   E     + +   +   + +     +++S+EL   R   ++ ES+  +L+
Sbjct: 1742 EARIAQLE---EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 174  KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
            +  + L S+L +++    S    +  +   E +  +L +++ Q+  + +   +   +   
Sbjct: 1799 RQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 234  NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV-KDLN 292
             L+   L++ED        KE   KG    +KQ++ +     E  +  N    K+ ++L+
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 293  QEIEKLKTQIKHFESLEEELK 313
            +  E  +   +   +L+ +L+
Sbjct: 1916 EATESNEAMGREVNALKSKLR 1936



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 54/230 (23%), Positives = 107/230 (46%), Gaps = 18/230 (7%)

Query: 8    KETASSRHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            +E ASS   R  LQ   RRL+  + +  + L++ +  +  + D+V +A      +  E+ 
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 67   VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-ELKSEIERLQKRMAELEKLEE 125
              R    + E   ++++R     + ++ KL E E   + + KS I  L+ ++A+LE+  E
Sbjct: 1782 TERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 126  AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
              +R K   T+   SL ++    K+I  ++E  R   ++ +   ++ +   + L  +LE+
Sbjct: 1839 QEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895

Query: 186  LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
             +        E + +N   +   KL +EL +  E N+ M R+     S L
Sbjct: 1896 AEE-------ESQRINANRR---KLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 31/144 (21%), Positives = 71/144 (49%), Gaps = 16/144 (11%)

Query: 5    TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKA-----EDELLDLQDKVIQA----E 55
            T+ K  ++ + L  + + L  +L E+E A K+  K+     E ++  L+++V Q     +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 56   GSNSSMLAEIEVLRQRVLRIEGK-------DEEIKRAEDLCRLMKEKLEEEENLTRELKS 108
             +  S+  + + L++ +L++E +        E+ ++     + +K +LEE E  ++ + +
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 109  EIERLQKRMAELEKLEEAFSRSKN 132
               +LQ+ + E  +  EA  R  N
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVN 1929


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
            + +  + DEL++  +  QKAE+EL +L+ K  Q  E  N         + + AE E +R 
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 910

Query: 71   RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
              +R+  K +E+   E++   M+ +LEEEE+  ++L++E +++ ++M +LE+   EE  +
Sbjct: 911  --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965

Query: 129  RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
            R K     L L         KK+  E+ ++        KE +  E+R+     +LA E E
Sbjct: 966  RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 185  KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
            K K+LT       S +SE +   +KE+++ + +++L +KLE +     +   D     + 
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 235  LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
            L+    + E+ + + L   +   +++   L  ++++E    +  E+       RN+ + +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 288  VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
             +DL +E+E LKT+++      + ++EL+  + +   +    L E+ ++           
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200

Query: 334  -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
                 + L  QLE+ K + K   +     +E E+A L+ +      +  G   +    K 
Sbjct: 1201 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1254

Query: 389  TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
               E   Q  + +  + E A   LN++ + L N   S     N    KA  +     S +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314

Query: 446  QETKKTED 453
             + + T++
Sbjct: 1315 SQLQDTQE 1322



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)

Query: 28   DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
            +E+E  T  L +AE + + L   V     S SS L + + L Q         EE ++  +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1333

Query: 88   LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
            +   +++  EE  +L  +L  E+E  Q     +  L    S SK        ++      
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393

Query: 148  TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
             K+   E+E L  + +E  ++ D+L+KT+  L  EL+    L +   ++R+ ++  EK+ 
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1450

Query: 208  EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
             K  + L ++   + K   +  R    A   E   L +   +   L +KE   +      
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510

Query: 265  KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
             ++E+   +K +  KN ++ +   + L  ++E++KTQ+   E LE+EL+  +     L+ 
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1567

Query: 325  NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
            N   L  Q +  L A   +  + + + Q++L   E E ED     +     + K  G   
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627

Query: 382  EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
            +  +   +A     E   Q ++ + + ++F    E+   S  ++ + +  N + AK+
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
            K     R L  +L++L   L++  ++T   Q    K E E+  L+  + +   S+ + + 
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195

Query: 64   EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
            E+     Q V  +  + E+ KRA+      K+ LE+E  +L  EL+   +  Q+   + +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
            KLE      ++ C+    +  E  +   K+ +E+E +   + E E    +L K   SL+S
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 182  EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            +L    E L+  T   ++    L + E+E   L  +L +++E  + + R  +     L  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375

Query: 238  NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
            +  +++D  S+    +E +++    + K++EN T+         +K E  KNR Q+  D+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 287  KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
             V DL+   Q +  L+ + + F+ L  E K + SK  D +D   +E    + K   LA  
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491

Query: 340  LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
            LEE  L+ K++ E  N  ++ E +  +SSK
Sbjct: 1492 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1520



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 92/392 (23%), Positives = 169/392 (43%), Gaps = 50/392 (12%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
            A +R    K  SL+R L+E  EA + L+      KAE E L     D+   V + E S  
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535

Query: 60   SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
            ++  ++E ++    ++E  ++E++  ED       KL  E N+ + LK + ER LQ R  
Sbjct: 1536 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1585

Query: 119  ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
            + E+      R  ++       L +ER      ++  + L   +K+LE   D   K  + 
Sbjct: 1586 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642

Query: 179  LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
               +L KL++    F  E       R  +    KENEK  K L   L Q ++     +  
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 230  RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
            R  ++LE+ +L  E  ++S+L  + + +        ++        E + N     ++V+
Sbjct: 1703 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 290  DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
               Q+ E+L  ++    S           LE + K+++SK ++++    + ++K K   +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1817

Query: 339  QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
             LE    Q+++Q E E  E +     L  K +
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 77/398 (19%), Positives = 168/398 (42%), Gaps = 60/398 (15%)

Query: 19   KLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
            +L+   R L+ ++EE    L++ EDEL   +D  ++ E +  ++  + E           
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 67   ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE--------EEENLTRELKSEIERLQ 114
                 L++++   E + E+ ++   L    K+KLE        + ++  +  +  I++L+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 115  KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDK 174
            K  A+++  +     ++    ++  +  E     K + ++L  L+  +   E +  + D 
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708

Query: 175  TEQSLASELEKLKSLTLSFVSERKYLN------EKEKENEK--------LIKELTQKLEQ 220
             ++ LA EL    S   +   E++ L       E+E E E+         +++ TQ+ EQ
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768

Query: 221  --------------NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
                          N+   +   R    L      +E  + S   S  +  +  +  L+ 
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828

Query: 266  QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNNDLQD 324
            QVE E R K    K+  Q+D K+K++  ++E  +   + + E  E+   ++K     L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 325  NYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
               +E+   ++ A++    KLQ +  +  E+ E  G +
Sbjct: 1889 ---AEEESQRINANRR---KLQRELDEATESNEAMGRE 1920



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            +L++  ++EE++  ED  +  KE+ ++ EN  +EL+ +  +L +    L++  +A +   
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
             +  ++ + L  ++   ++I  E+E        LE  EDR     Q L +E +K+    L
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 953

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
                  + L E+E   +KL  E      + KK+             +++ + D  ++ L 
Sbjct: 954  DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 997

Query: 252  SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
            SKE  RK   + +  +      + E  KN  +  NK + +  E+E +LK + K  + LE+
Sbjct: 998  SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 311  ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
              +K++   +D  +           L +Q+ E+K+Q+ KK++EL+      +D       
Sbjct: 1056 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108

Query: 370  RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
              ++ +   GH S+      S+  AR  + + KR+     E AL  E   L +   S+ +
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1164

Query: 426  FTNRRAAKASHMGVSTDSGTQETKKTE 452
                RA +   + V   +  +ET+  E
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHE 1191



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 66/321 (20%), Positives = 141/321 (43%), Gaps = 26/321 (8%)

Query: 11   ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            A+ + L   L+ L  + D      EEA K L+K + ++ D Q ++  A  S   + A  +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 67   VLRQRVLRIEGKDEEIKRAEDLC---RLMKEKLEEEENLTRELKSEIE----------RL 113
               ++   +E    +++  EDL    R  K+   E+E L  EL S +           RL
Sbjct: 1677 ENEKKAKSLEADLMQLQ--EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734

Query: 114  QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD 173
            + R+A+LE   E     + +   +   + +     +++S+EL   R   ++ ES+  +L+
Sbjct: 1735 EARIAQLE---EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 174  KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
            +  + L S+L +++    S    +  +   E +  +L +++ Q+  + +   +   +   
Sbjct: 1792 RQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 234  NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV-KDLN 292
             L+   L++ED        KE   KG    +KQ++ +     E  +  N    K+ ++L+
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 293  QEIEKLKTQIKHFESLEEELK 313
            +  E  +   +   +L+ +L+
Sbjct: 1909 EATESNEAMGREVNALKSKLR 1929



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 54/230 (23%), Positives = 107/230 (46%), Gaps = 18/230 (7%)

Query: 8    KETASSRHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            +E ASS   R  LQ   RRL+  + +  + L++ +  +  + D+V +A      +  E+ 
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 67   VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-ELKSEIERLQKRMAELEKLEE 125
              R    + E   ++++R     + ++ KL E E   + + KS I  L+ ++A+LE+  E
Sbjct: 1775 TERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 126  AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
              +R K   T+   SL ++    K+I  ++E  R   ++ +   ++ +   + L  +LE+
Sbjct: 1832 QEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888

Query: 186  LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
             +        E + +N   +   KL +EL +  E N+ M R+     S L
Sbjct: 1889 AEE-------ESQRINANRR---KLQRELDEATESNEAMGREVNALKSKL 1928



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 31/144 (21%), Positives = 71/144 (49%), Gaps = 16/144 (11%)

Query: 5    TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKA-----EDELLDLQDKVIQA----E 55
            T+ K  ++ + L  + + L  +L E+E A K+  K+     E ++  L+++V Q     +
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 56   GSNSSMLAEIEVLRQRVLRIEGK-------DEEIKRAEDLCRLMKEKLEEEENLTRELKS 108
             +  S+  + + L++ +L++E +        E+ ++     + +K +LEE E  ++ + +
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 109  EIERLQKRMAELEKLEEAFSRSKN 132
               +LQ+ + E  +  EA  R  N
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVN 1922


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 70/351 (19%), Positives = 161/351 (45%), Gaps = 47/351 (13%)

Query: 11  ASSRHLRFKLQSLSRRLD---ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
           A + HL  +LQS+S +L    E  E    L + ++E +  Q++ IQ            E 
Sbjct: 253 AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQERE---------EK 303

Query: 68  LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
           ++++  +I  ++E+++R E++    +EK+  +E +  E + +I  L+++M E EK+ E  
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE-- 361

Query: 128 SRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187
              K    +      + +    K+  + E +R + +++   E+ + + E+ +  + EK+ 
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421

Query: 188 SLTLSFVSERKYL---NEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
                   + + +    EK +E EK I+E  +K+ + ++M                    
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM-------------------- 461

Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQED---NKVKDLNQEIEKLKTQ 301
                   +E   K G    K  E E + + + EK R QE+    + K + ++ EK++ Q
Sbjct: 462 -------MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514

Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE 352
            +  +  EE++ + + K  + ++    ++ K +    ++ E ++++++Q+E
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 78/350 (22%), Positives = 161/350 (46%), Gaps = 37/350 (10%)

Query: 65  IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLE 124
           +E+ R  +   E K++  K  E L  +  EK E + N+ +ELK ++ER +  + + +   
Sbjct: 195 LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-KELKRKLERAKLLLPQQQLQA 253

Query: 125 EA--FSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKE-LESSEDRLDKTEQSLAS 181
           EA    +     +    +  EE  L  +++ + E    + +E ++  E+++ + E+ +  
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE 313

Query: 182 ELEKLKSLT-LSFVSERKYLNEKEK--ENEKLIKELTQKLEQNKKMNRDYTRNASNLERN 238
           + EK++    + +  E K   ++E   E E+ I+EL +K+ + +K+           E+ 
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR----------EQE 363

Query: 239 DLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKL 298
           + R E+     +  +E R++      K    E + + + EK R QE+     + ++ EK+
Sbjct: 364 EKRQEE---EKIREQEKRQE---QEAKMWRQEEKIREQEEKIREQEEM----MQEQEEKM 413

Query: 299 KTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELEN--G 356
             Q +     EEE+++ + K    Q+  + EQ K   +  Q E+I+ Q +  +E E   G
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMR-RQEEKIREQEKK--IREQEEKIREQEEMMQEQEEKMG 470

Query: 357 EVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406
           E EG+     +K + +  K R    +    +   RE     + E++R +E
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE-----QEEKIREQE 515



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 35/198 (17%), Positives = 104/198 (52%), Gaps = 15/198 (7%)

Query: 25  RRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKR 84
           R+ +++ E  + +++ E+ + + ++K+ + E     M  + E ++++  ++  ++E+I+ 
Sbjct: 387 RQEEKIREQEEKIREQEEMMQEQEEKMGEQE---EKMWEQEEEMQEQEEKMRRQEEKIRE 443

Query: 85  AEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKNDCTQLCLSLNE 143
            E   R  +EK+ E+E + +E + ++   + +M E E K++E   + +    ++     +
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503

Query: 144 ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEK 203
            R   +KI  + EM++ + +++   E+++ + E+ +  + EK++              EK
Sbjct: 504 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-----------QEEK 552

Query: 204 EKENEKLIKELTQKLEQN 221
            +E E  +++  +K++++
Sbjct: 553 MREQEVRLRQQEEKMQEH 570


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 107/497 (21%), Positives = 207/497 (41%), Gaps = 99/497 (19%)

Query: 35   KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVL--------RIEGKDEEIKRAE 86
            + LQ  ++ELL +++K  + EG     L E+E   Q++L        +++ + E    AE
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGE----LEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907

Query: 87   DLCRLMKEKLEEEENLTRELKSEIERLQKR-----------MAELEKLEEAFSRSKNDCT 135
            ++   +  K +E E +  +L+S +E  ++R            A ++ LEE     +    
Sbjct: 908  EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967

Query: 136  QLCLSLNEERNLTKKISSELEMLRVK----VKELESSEDRLDKTEQSLASELEKLKSLTL 191
            +L L         KK+  E+ +L  +    +KE +  EDR+ +    LA E EK K+L  
Sbjct: 968  KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA- 1026

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS--- 248
                      +   + E +I +L ++L++ +K  ++  +    L+     ++D I+    
Sbjct: 1027 ----------KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076

Query: 249  -------TLPSKESRRKGGL-----------DYLKQVEN------ETRNKSENEK-NRNQ 283
                    L  KE   +G L           + LK V        E +   E+EK +RN+
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136

Query: 284  EDNKVKDLNQEIEKLKTQIKHF----------------------ESLEEELKKMKSKNND 321
             + + +DL++E+E LKT+++                        ++LEEE K  +++  D
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196

Query: 322  LQDNYLSEQNKNKLLASQLEEIKLQIKKQK---ELENGEVEGEDAFL---SSKGRHERTK 375
            ++  + +   +      Q +  K  ++K K   E +N E+  E   L    ++  H+R K
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256

Query: 376  FRGHGSE--ASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAK 433
                  E  A VS+     +    K  +L+N    L+N +  L   +     F    A+ 
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNE---LDNVSTLLEEAEKKGIKFAKDAASL 1313

Query: 434  ASHMGVSTDSGTQETKK 450
             S +  + +   +ET++
Sbjct: 1314 ESQLQDTQELLQEETRQ 1330



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 94/417 (22%), Positives = 192/417 (46%), Gaps = 83/417 (19%)

Query: 14   RHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLAEIEVLR 69
            + ++  +Q L  +LDE E A + LQ     AE ++  ++++++  E  NS  + E +++ 
Sbjct: 946  KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005

Query: 70   QRVLRIEGK-DEEIKRAEDLCRL----------MKEKLEEEENLTRELKS-------EIE 111
             R+     +  EE ++A++L ++          ++E+L++EE   +EL+        E  
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065

Query: 112  RLQKRMAEL---------------EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELE 156
             LQ ++AEL               E+L+ A +R  ++     L  N    + +++ +++ 
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET----LHKNNALKVVRELQAQIA 1121

Query: 157  MLRVKVKELESSEDRLDKTEQSLASELEKLKSL---TLSF--------------VSERKY 199
             L+   +  ++S ++ +K ++ L+ ELE LK+    TL                V+E K 
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181

Query: 200  LNEKEKENEK------------LIKELTQKLEQNKKMNRDYTRNASNLE--RNDLRIEDG 245
              E+E +N +             ++EL+++LEQ K+   +  +N   LE    +L  E  
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241

Query: 246  ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
            +   + ++   ++  LD   QV+      SE ++ R +   K   L  E++ + T ++  
Sbjct: 1242 VLQQVKAESEHKRKKLD--AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299

Query: 306  E----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS----QLEEIKLQIKKQKELE 354
            E       ++   ++S+  D Q+  L E+ + KL  S    QLEE K  +++Q+E E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQE-LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 83/393 (21%), Positives = 166/393 (42%), Gaps = 32/393 (8%)

Query: 9    ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV- 67
            E A  + ++F   + S    +L++  + LQ+   + L+L  ++ Q E   +S+  + E  
Sbjct: 1297 EEAEKKGIKFAKDAASLE-SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355

Query: 68   ------LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEE-EENLTRELKSEIERLQKRMAEL 120
                  L ++VL ++ +  + K+  D      E LEE ++ L ++ ++  +RL+++    
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
            +KLE+  +R + +   L + L+ +R +   +  + +     + E +S   R  +      
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
            +E  + ++  LS     +   E ++E E+  K+L   +E       D  +N   LE++  
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535

Query: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSEN---EKNRNQEDNKVKDLNQEIEK 297
             +E  +       E       D L+  E+       N    K + + D + +D  Q  EK
Sbjct: 1536 ALEQQVEEMRTQLEELE----DELQATEDAKLRLEVNMQAMKAQFERDLQTRD-EQNEEK 1590

Query: 298  LKTQIKHFESLEEEL--------------KKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
             +  IK    LE EL              KKM+    DL+    +       +  QL ++
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650

Query: 344  KLQIKK-QKELENGEVEGEDAFLSSKGRHERTK 375
            + Q+K  Q+ELE      ++ F  SK   ++ K
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 69/295 (23%), Positives = 133/295 (45%), Gaps = 35/295 (11%)

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
            +L++  ++EE++  ++    +KEK         +++ E+E ++++  +L + +   +   
Sbjct: 844  LLQVTRQEEELQAKDEELLKVKEK-------QTKVEGELEEMERKHQQLLEEKNILAEQL 896

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
               T+L     E R        ELE +   + +LES  +  ++  Q L +E +K+++   
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEI---LHDLESRVEEEEERNQILQNEKKKMQA--- 950

Query: 192  SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
                  + L+E+E   +KL  E      + KKM           E   L +ED  S  + 
Sbjct: 951  HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM-----------EEEILLLEDQNSKFIK 999

Query: 252  SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE 311
             K+       +   Q+  E        K RN+++  + DL    E+LK + K  + LE+ 
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE---ERLKKEEKTRQELEKA 1056

Query: 312  LKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFL 365
             +K+  +  DLQD           L +Q++E+KLQ+ KK++EL+     G+D  L
Sbjct: 1057 KRKLDGETTDLQDQIAE-------LQAQIDELKLQLAKKEEELQGALARGDDETL 1104



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 83/361 (22%), Positives = 159/361 (44%), Gaps = 42/361 (11%)

Query: 12   SSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQR 71
            +   L+ +L  L+  LD   +   NL+K + +     D+++  E S S+  AE    R R
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF----DQLLAEEKSISARYAEE---RDR 1473

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRE---LKSEIERLQ-------KRMAELE 121
                E +++E K A  L R ++E LE +E   R+   L++++E L        K + ELE
Sbjct: 1474 A-EAEAREKETK-ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
            K + A  +   +       L +E   T+     LE+       +++ + + ++  Q+   
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV------NMQAMKAQFERDLQTRDE 1585

Query: 182  ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
            + E+ K L +  V E     E E E+E+  K+    +   KKM  D     + +E  + +
Sbjct: 1586 QNEEKKRLLIKQVREL----EAELEDER--KQRALAVASKKKMEIDLKDLEAQIEAAN-K 1638

Query: 242  IEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
              D +   L   +++ K   DY +++E    ++ E      + + K+K L  EI +L+ +
Sbjct: 1639 ARDEVIKQLRKLQAQMK---DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695

Query: 302  I-------KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
            +       +H E   +EL    + +   +   L E+ + +   +QLEE   + +   EL 
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755

Query: 355  N 355
            N
Sbjct: 1756 N 1756



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 80/401 (19%), Positives = 170/401 (42%), Gaps = 72/401 (17%)

Query: 19   KLQSLSRRLDE-LEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
            +L+   R L++ +EE    L++ EDEL   +D  ++ E +  +M A+ E           
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588

Query: 67   ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE----------EEENLTR-ELKSEIE 111
                +L ++V  +E + E+ ++   L    K+K+E          E  N  R E+  ++ 
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648

Query: 112  RLQKRMAELEK-LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
            +LQ +M + ++ LEEA  R+  D  ++     E     K + +E+  L+ ++   E +  
Sbjct: 1649 KLQAQMKDYQRELEEA--RASRD--EIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704

Query: 171  RLDKTEQSLASELEKLKSLTLSFVSERKYLN----------EKEKENEKLIKELTQKL-- 218
              ++    LA E+    S   + + E++ L           E+E+ N +L+ +  +K   
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764

Query: 219  -----------EQNKKMNRDYTRNASNLERNDLR-----IEDGISSTLPSKESRRKGGLD 262
                       E++     D  R     +  +L+     +E  + S   +  S  +  + 
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824

Query: 263  YLK-QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNN 320
             L+ Q+E E + ++   K   + + K+K++  ++E  +     + E +E+   +MK    
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884

Query: 321  DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
             L++   +E+   +  AS+        K Q+EL++     E
Sbjct: 1885 QLEE---AEEEATRANASRR-------KLQRELDDATEANE 1915



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 61/327 (18%), Positives = 141/327 (43%), Gaps = 48/327 (14%)

Query: 11   ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
            AS + +   L+ L  +++      +E  K L+K + ++ D Q ++ +A  S   + A+ +
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676

Query: 67   VLRQRVLRIEGK----DEEIKRAEDLCRLMKEK------------------LEEEENLTR 104
               +++  +E +     EE+  +E   R  +++                  L+E+  L  
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736

Query: 105  ELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEER-------NLTKKISSELEM 157
             +    E L++  + +E L + F ++      L   L  ER       N  +++  + + 
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796

Query: 158  LRVKVKELESS-EDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQ 216
            L+ K++ELE + + +   T  +L +++ +L+        ER   N+  +  EK +KE+  
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856

Query: 217  KLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE 276
            ++E  ++    Y      +E+ + R++        ++E   +          N +R K +
Sbjct: 1857 QVEDERRHADQY---KEQMEKANARMKQLKRQLEEAEEEATRA---------NASRRKLQ 1904

Query: 277  NEKNRNQEDNKVKDLNQEIEKLKTQIK 303
             E +   E N  + L++E+  LK +++
Sbjct: 1905 RELDDATEAN--EGLSREVSTLKNRLR 1929


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 103/436 (23%), Positives = 192/436 (44%), Gaps = 40/436 (9%)

Query: 11   ASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLD----LQDKVIQAEGSNSSMLAEIE 66
            A    LR KLQ L     +LEEA    Q+ E  L      L+ ++ +A+   + +  E +
Sbjct: 758  AVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQ 817

Query: 67   VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEA 126
             L  R L  EGK  E+ R        K +LEE++ L   L   ++RL K   ELEK+ E 
Sbjct: 818  TLN-RALEEEGKQREVLRRG------KAELEEQKRL---LDRTVDRLNK---ELEKIGED 864

Query: 127  FSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
               SK    QL   L + +   +K   E+   + + K+  S  ++       L  E+++L
Sbjct: 865  ---SKQALQQLQAQLEDYK---EKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918

Query: 187  KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIE--- 243
            +    +  +ER      ++   + ++ L Q+ E  K+   D  R    LE    R+E   
Sbjct: 919  RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL 978

Query: 244  DGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIK 303
            D   +T+     R   G D + Q+  E     E    ++ E +K+  L ++ + LKT++ 
Sbjct: 979  DEEKNTVELLTDRVNRGRDQVDQLRTELMQ--ERSARQDLECDKIS-LERQNKDLKTRLA 1035

Query: 304  HFESLEE---ELKKMKSKNNDLQDNYLSE-------QNKNKLLASQLEEIKLQIKKQKEL 353
              E  ++    L +++S+N  LQ+   +E       Q+ N+ L  +++E+ +QI+ +++ 
Sbjct: 1036 SSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQH 1095

Query: 354  ENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHK-RERLRNREFALNNE 412
             N + +     + +  R              + K   RE+  QH+  E+L+ R  +L  +
Sbjct: 1096 VNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155

Query: 413  NYSLSNRQVSSPSFTN 428
            ++  ++R  +  +  N
Sbjct: 1156 SWRKASRSAAESALKN 1171



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 73/339 (21%), Positives = 141/339 (41%), Gaps = 20/339 (5%)

Query: 20   LQSLSRRLDELEE-ATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
            LQ L  +L++ +E A + +  A+ +  D   +  +  G  S +  EI+ LRQ +   + +
Sbjct: 869  LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928

Query: 79   DEEIKRAEDLCRLMKEKLEEE-ENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
             +  +  ++L     + LE+E EN  R       +L+    ++ +LE      KN    L
Sbjct: 929  RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988

Query: 138  CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
               +N  R+   ++ +EL   R   ++LE  +  L++  + L + L   +     F    
Sbjct: 989  TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE----GFQKPS 1044

Query: 198  KYLNEKEKENEKLIKELTQKLEQNKKM----NRDYTRNASNLERNDLRIEDGISSTLPSK 253
              L++ E +N+ L++E  Q  E+ K +    NR   R    L    ++IED        K
Sbjct: 1045 ASLSQLESQNQ-LLQERLQAEEREKTVLQSTNRKLERKVKEL---SIQIEDERQHVNDQK 1100

Query: 254  ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
            +          +QV+         +  R +   +V++ ++  E+L+ +IK  E       
Sbjct: 1101 DQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKA 1160

Query: 314  KMKSKNNDLQDNYLSEQNK------NKLLASQLEEIKLQ 346
               +  + L++  LS   +         +AS L E  LQ
Sbjct: 1161 SRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQ 1199



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 80/397 (20%), Positives = 171/397 (43%), Gaps = 35/397 (8%)

Query: 75  IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDC 134
           + G+ E  ++ E+L R + E++++ + L         +L+++  E  +L+E   R K + 
Sbjct: 358 VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA 417

Query: 135 TQ-------LCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187
            Q       +   L++  +L   + +++  L+ K+K ++  E   +   + L    E L+
Sbjct: 418 QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE 477

Query: 188 SLT--LSFVSERKYLNEKEKENEK--LIKELTQKLEQNKKMNRDYTRNASNLERN--DLR 241
            +      V E+  L E+E    K  L +E+  + ++ + + + Y R+   L R+  D  
Sbjct: 478 EVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT 537

Query: 242 IEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
            +  +      K S    GL    +  +E     ++   +N+ED  ++   QE+ +L+ +
Sbjct: 538 QDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED--LRATKQELLQLRME 595

Query: 302 IKHFESLEEEL-KKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
               E +EEEL +K++    +L+    S  +       Q+E +K ++ + +E E  E++ 
Sbjct: 596 ---KEEMEEELGEKIEVLQRELEQARASAGD-----TRQVEVLKKELLRTQE-ELKELQA 646

Query: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSN-- 418
           E       GRH   +     +   V     REL  Q+ + +   ++   + E  S +   
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706

Query: 419 RQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRF 455
            +  +     RRAA         ++  +ET++  D F
Sbjct: 707 AEAEATVLGQRRAA--------VETTLRETQEENDEF 735



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 145/723 (20%), Positives = 287/723 (39%), Gaps = 78/723 (10%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELL-DLQDK-----VIQAEGSNSSMLAEIEVLRQRVLR 74
            + ++ R  E+E   +  Q+  ++L   +QD      V++AE    S L     +R     
Sbjct: 506  EEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSAL-----VRGLQRE 560

Query: 75   IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-LEKLEEAFSRSKND 133
            +E   EE    + + +  KE L   +    +L+ E E +++ + E +E L+    +++  
Sbjct: 561  LEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQAR-- 618

Query: 134  CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
                  S  + R + + +  EL   + ++KEL++     +   +    ELEK  ++    
Sbjct: 619  -----ASAGDTRQV-EVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672

Query: 194  VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
                + L E+  + +K +++L Q  E+  K        A+ L +    +E  +  T    
Sbjct: 673  ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732

Query: 254  ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
            +  R+  L  L+Q   ETR   +  +     + +++D  Q +E  K Q      LEE L 
Sbjct: 733  DEFRRRILG-LEQQLKETRGLVDGGE---AVEARLRDKLQRLEAEKQQ------LEEAL- 781

Query: 314  KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI----KKQKELENG-EVEGEDAFLSSK 368
                  N  Q+   S     + L ++LEE +  +    ++Q+ L    E EG+   +  +
Sbjct: 782  ------NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835

Query: 369  GRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY-SLSNRQVSSPSFT 427
            G+ E  + +          +   E   +  ++ L+  +  L  E+Y   + R+V+     
Sbjct: 836  GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL--EDYKEKARREVAD---A 890

Query: 428  NRRAAKASHMGVSTDSGTQETKKTEDRFVPG--SSQSEGKKSREQPSVLSRYPPAAQEHS 485
             R+A   +     T  G    +    R      +SQ+E   +R    +L++     ++ +
Sbjct: 891  QRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 950

Query: 486  KAWKGTSKPGTESGLKGKVEKTTR--TFSDTTHGSVP--SDPLGRADKASDTSSETVFGK 541
            +  K  S+      LKG  EK +R  T  D    +V   +D + R     D     +  +
Sbjct: 951  EN-KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009

Query: 542  RGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPV 601
            R     +  Q  +       +    L  +R +SSEG  K   + + LE+ N        +
Sbjct: 1010 R-----SARQDLECDKISLERQNKDL-KTRLASSEGFQKPSASLSQLESQNQ-------L 1056

Query: 602  LSKYPYSCRSQENILQGFSTSHK-EGVNQPAAVVMEDSSPHE-------ALRCRVIKSSG 653
            L +   +   ++ +LQ  ST+ K E   +  ++ +ED   H        +LR + +K   
Sbjct: 1057 LQERLQAEEREKTVLQ--STNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114

Query: 654  REKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGM 713
             E  +  + LD       + V        + + +  S EK   R A R++     K+ G+
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGL 1174

Query: 714  ENE 716
             ++
Sbjct: 1175 SSD 1177


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 112/478 (23%), Positives = 207/478 (43%), Gaps = 72/478 (15%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEAT----KNLQKAEDELLDLQDKVIQAE-------- 55
            KE  +S  LR KL    ++  +LE       + + + E+EL  ++++V+Q E        
Sbjct: 1305 KEEVAS--LRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEP 1362

Query: 56   ---GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER 112
                  S+    I+V  +++ ++  +   ++R         E+LE E    RE + E++R
Sbjct: 1363 GLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422

Query: 113  LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
            LQ+R+A LE+ EEA +R K   TQ  +   + +      + E  +LR+   +LE  + R 
Sbjct: 1423 LQQRLAALEQ-EEAEAREKVTHTQKVVLQQDPQQ-----AREHALLRL---QLEEEQHRR 1473

Query: 173  DKTEQSLASELEKLKSLTLSFVSERKYLNE----KEKENEKLIKELTQKLEQNKKMNRDY 228
               E  L +   KL +L  + V E+  L+E    ++ + E+ I+ L   LE+  +  R+ 
Sbjct: 1474 QLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKREL 1533

Query: 229  TRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV 288
                S LE           S L    S+    LD+L++         EN K + +  N  
Sbjct: 1534 DVEVSRLEAR--------LSELEFHNSKSSKELDFLRE---------ENHKLQLERQN-- 1574

Query: 289  KDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
              L  E  +L+++I    +   +L+ M      + D+  +  ++   L  +L+++K ++ 
Sbjct: 1575 --LQLETRRLQSEINMAATETRDLRNM-----TVADSGTNHDSRLWSLERELDDLK-RLS 1626

Query: 349  KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE-------- 400
            K K+LE  E++     ++ K        R   S   +   T RELSP+            
Sbjct: 1627 KDKDLEIDELQKRLGSVAVKREQRENHLR--RSIVVIHPDTGRELSPEEAHRAGLIDWNM 1684

Query: 401  --RLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFV 456
              +LR++E   + E  S+      S    +R++ K   +  +  SG + T    DR+V
Sbjct: 1685 FVKLRSQE--CDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSG-RLTPAQYDRYV 1739



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 57/275 (20%), Positives = 119/275 (43%), Gaps = 53/275 (19%)

Query: 92  MKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKI 151
           M+ KL+ ++NL  E+ S  + +QK  A  ++ ++A    + +  +L   L+ E   +  +
Sbjct: 763 METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHV 822

Query: 152 SSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLI 211
           S        K   L+S   ++ + E +LA++  ++ +           +N +  +N +  
Sbjct: 823 S--------KRARLQSPATKVKEEEAALAAKFTEVYA-----------INRQRLQNLEFA 863

Query: 212 KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENET 271
             L ++  + +  +    RN         R + G+      +           K+++ ET
Sbjct: 864 LNLLRQQPEVEVTHETLQRN---------RPDSGVEEAWKIR-----------KELDEET 903

Query: 272 RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK------MKSKNNDLQDN 325
                  + R Q +N+VK   +EI  L+ Q      + +E+ K      ++     LQ  
Sbjct: 904 -------ERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRT 956

Query: 326 YLSEQNKNKLLASQLEEIKLQIKK-QKELENGEVE 359
              EQ+KN+LL  +LE ++LQ++  ++E  +G  E
Sbjct: 957 LAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 78/394 (19%), Positives = 171/394 (43%), Gaps = 54/394 (13%)

Query: 29   ELEEATKNLQKAEDELLDLQDKV--IQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAE 86
            EL+E T+  ++ E+E+   Q+++  ++ +G   S      V+R+ VL+ +  D  +   E
Sbjct: 898  ELDEETERRRQLENEVKSTQEEIWTLRNQGPQES------VVRKEVLK-KVPDPVL---E 947

Query: 87   DLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERN 146
            +  + ++  L EE++  + L+ E+E LQ ++  LE  +E     +    +  L +  +R 
Sbjct: 948  ESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALE--QETRDGGQEYVVKEVLRIEPDRA 1005

Query: 147  LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE 206
               ++    E L    ++  + E  +   +Q +A+  E                 EK + 
Sbjct: 1006 QADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAE-----------------EKSRA 1048

Query: 207  NEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL---RIEDGIS------STLPSKESRR 257
             EK+ ++   KL+ + ++  +Y +   + +R D    + E+ +S        L  + +  
Sbjct: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108

Query: 258  KGGL---DYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK 314
            +G +   + LK  ++    +  ++  R  ED   K    + EK +  ++   +LEEE  K
Sbjct: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTEL-LRKIWALEEENAK 1167

Query: 315  MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
            +      +Q+        +    S++  ++L++ +Q+    G    E+   S +   E  
Sbjct: 1168 VV-----VQEKVREIVRPDPKAESEVANLRLELVEQERKYRG---AEEQLRSYQSELEAL 1219

Query: 375  KFRGHGSEA-SVSKHTAR-ELSPQHKRERLRNRE 406
            + RG   E   V+K   + +  P+ ++E  R RE
Sbjct: 1220 RRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLRE 1253



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 76/356 (21%), Positives = 134/356 (37%), Gaps = 47/356 (13%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE- 66
           +E A +  LR  L+   R + +  E  K+L+   +ELL ++ +  ++     + +  +  
Sbjct: 521 QEKAITGILRPPLEQ-GRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579

Query: 67  -----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
                +LR RV     K E + +  DL +   EK++    L + L+   E L      L 
Sbjct: 580 SGTTPLLRTRVEDTNRKYEHLLQLLDLAQ---EKVDVANRLEKSLQQSWELLATHENHLN 636

Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
           + +     S+                   + S+ + L     EL++ +  L + EQ+L +
Sbjct: 637 QDDTVPESSR------------------VLDSKGQELAAMACELQAQKSLLGEVEQNLQA 678

Query: 182 ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
             +   +L   F      L  +E E  KL +     L Q  +      ++A     +  R
Sbjct: 679 AKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNN-LRQQVERRAQSLQSAKAAYEHFHR 737

Query: 242 IEDGISSTLPSKESRRKGGLDYLKQVENETRNKS-----------ENEK---NRNQEDNK 287
             D +   L S  S      D L Q+E + +N+            E +K   N  Q    
Sbjct: 738 GHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA 797

Query: 288 VKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
           VKD   E EKL++ +     LE       SK   LQ      + +   LA++  E+
Sbjct: 798 VKDYELEAEKLRSLL----DLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV 849



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 93/423 (21%), Positives = 172/423 (40%), Gaps = 54/423 (12%)

Query: 14  RHLRFKLQSLSRRLDELEEA--TKNLQKAED----ELLDLQDKVIQAEGSNSSMLAEIEV 67
           R +R K     R L +  E   T+N   A D    +LL   DKV  A   +    A   +
Sbjct: 471 RSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKV--ASDLDRQEKAITGI 528

Query: 68  LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-----LEK 122
           LR  + +     +  +RA+DL  +  E L  E   TR        +Q          L  
Sbjct: 529 LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT 588

Query: 123 LEEAFSRSKNDCTQLCLSLNEER-----NLTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
             E  +R      QL L L +E+      L K +    E+L      L + +D + ++ +
Sbjct: 589 RVEDTNRKYEHLLQL-LDLAQEKVDVANRLEKSLQQSWELLATHENHL-NQDDTVPESSR 646

Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            L S+ ++L ++     +++  L E E +N +  K+ +  L         +  +  +LER
Sbjct: 647 VLDSKGQELAAMACELQAQKSLLGEVE-QNLQAAKQCSSTLASR------FQEHCPDLER 699

Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRN----KSENEKNRNQEDNKVKDLNQ 293
            +  +          K  +R   L   +QVE   ++    K+  E      D+ ++ L  
Sbjct: 700 QEAEVH---------KLGQRFNNLR--QQVERRAQSLQSAKAAYEHFHRGHDHVLQFL-- 746

Query: 294 EIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ------LEEIKLQI 347
            +     + +  +SL +   K+K++ N L +    EQ   K+ A+       +++ +L+ 
Sbjct: 747 -VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEA 805

Query: 348 KKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREF 407
           +K + L + E  G  + +S + R +    +    EA+++       +    R+RL+N EF
Sbjct: 806 EKLRSLLDLE-NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAIN--RQRLQNLEF 862

Query: 408 ALN 410
           ALN
Sbjct: 863 ALN 865


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 92/390 (23%), Positives = 179/390 (45%), Gaps = 37/390 (9%)

Query: 14   RHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE------ 66
            + +R  L+   R+L+ +L+   +++   E++ L L++K+ + E   +   ++IE      
Sbjct: 1044 KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLA 1103

Query: 67   -----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKR----- 116
                  L++   RIE  +EE++ AE   R   EKL  +  L+REL+   ERL++      
Sbjct: 1104 LQLQKKLKENQARIEELEEELE-AERTARAKVEKLRSD--LSRELEEISERLEEAGGATS 1160

Query: 117  -MAELEKLEEA-FSRSKNDCTQLCLSLNEERN-LTKKISSELEMLRVKVKELESSEDRLD 173
               E+ K  EA F + + D  +  L        L KK +  +  L  ++  L+  + +L+
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220

Query: 174  KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
            K +     EL+ + S     +  +  L +  +  E    E   KLE+ ++   D+T    
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT---- 1276

Query: 234  NLERNDLRIEDG-ISSTLPSKES----RRKGGLDYLKQVENETRNKSENEKNRNQEDNKV 288
              +R  L+ E+G ++  L  KE+      +G L Y +Q+E+  R   E  K +N   + +
Sbjct: 1277 -TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL 1335

Query: 289  KDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQI 347
            +    + + L+ Q +     + EL+++ SK N     + ++   + +    +LEE K ++
Sbjct: 1336 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1395

Query: 348  KKQKELENGEVEGEDAFLSSKGRHERTKFR 377
             ++ +     VE  +A  SS    E+TK R
Sbjct: 1396 AQRLQDAEEAVEAVNAKCSSL---EKTKHR 1422



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 72/284 (25%), Positives = 138/284 (48%), Gaps = 32/284 (11%)

Query: 147  LTKKISSELEMLRVK-----VKE-LESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL 200
            L K   +E EM  +K     +KE LE SE R  + E+ + S L++   L L   +E+  L
Sbjct: 841  LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900

Query: 201  NEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGG 260
            N+ E+  ++LIK   Q   + K+MN          ER  L  E+ +++ L +K+ + +  
Sbjct: 901  NDAEERCDQLIKNKIQLEAKVKEMN----------ER--LEDEEEMNAELTAKKRKLEDE 948

Query: 261  LDYLKQ-VENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKN 319
               LK+ +++     ++ EK ++  +NKVK+L +E+  L   I     L +E K ++  +
Sbjct: 949  CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII---AKLTKEKKALQEAH 1005

Query: 320  NDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGH 379
                D+   E++K     + L + K+++++Q +   G +E E        R +R K  G 
Sbjct: 1006 QQALDDLQVEEDK----VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR-KLEG- 1059

Query: 380  GSEASVSKHTARELSPQ--HKRERLRNREFALNNENYSLSNRQV 421
              +  +++ +  +L        E+L+ +EF +N +N  + + QV
Sbjct: 1060 --DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQV 1101



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 91/412 (22%), Positives = 184/412 (44%), Gaps = 45/412 (10%)

Query: 28   DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
            +E     + L+K+E    +L++K++       S+L E   L+   L+++ + + +  AE+
Sbjct: 856  EEFGRIKETLEKSEARRKELEEKMV-------SLLQEKNDLQ---LQVQAEQDNLNDAEE 905

Query: 88   LC-RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERN 146
             C +L+K K++ E  + +E+   +E  ++  AEL   +    + +++C++L   +++   
Sbjct: 906  RCDQLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKR---KLEDECSELKKDIDDLEL 961

Query: 147  LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL-----KSLTLSFVSERKY-- 199
               K+  E      KVK L      LD+    L  E + L     ++L    V E K   
Sbjct: 962  TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021

Query: 200  LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKG 259
            L++ + + E+ + +L   LEQ KK+  D       LER   ++E  +  T  S       
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLEQEKKVRMD-------LERAKRKLEGDLKLTQESIMDLEND 1074

Query: 260  GLDYLKQVENETRNK--SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKS 317
             L    Q+E + + K    N++N   ED +V  L  + +KLK      E LEEEL+  ++
Sbjct: 1075 KL----QLEEKLKKKEFDINQQNSKIEDEQVLALQLQ-KKLKENQARIEELEEELEAERT 1129

Query: 318  KNNDLQDNYLSEQNKNKLLASQLEE--------IKLQIKKQKELENGEVEGEDAFLSSKG 369
                ++        + + ++ +LEE        I++  K++ E +    + E+A L  + 
Sbjct: 1130 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189

Query: 370  RHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQV 421
                 + +   S A + +        + K E+ ++ EF L  ++ + +  Q+
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS-EFKLELDDVTSNMEQI 1240



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 115/562 (20%), Positives = 229/562 (40%), Gaps = 90/562 (16%)

Query: 17   RFKLQSLSRRLDELEEATKNLQKAEDELL-DLQDK---VIQAEGSNSSMLAEIEVLRQRV 72
            R KL+   R L++       LQ    EL   L++K   + Q      S   ++E L+ R 
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK-RQ 1320

Query: 73   LRIEGKDEE-----IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA--------- 118
            L  EGK +      ++ A   C L++E+ EEE     EL+  + +    +A         
Sbjct: 1321 LEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1380

Query: 119  ------ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK----ISSELEMLRVKVKELESS 168
                  ELE+ ++  ++   D  +   ++N + +  +K    + +E+E L V V+   ++
Sbjct: 1381 AIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440

Query: 169  EDRLDKTEQ----------------------------SLASELEKLKSLTLSFVSERKYL 200
               LDK ++                            SL++EL KLK+   ++    ++L
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN---AYEESLEHL 1497

Query: 201  NEKEKENEKL---IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
               ++EN+ L   I +LT++L +  K   +  +    LE   L ++  +     S E   
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557

Query: 258  ----KGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI-KHFESLEEEL 312
                +  L++  Q++ E   K   EK+   E  K ++  + ++ L+T +     S  E L
Sbjct: 1558 GKILRAQLEF-NQIKAEIERKLA-EKDEEMEQAK-RNHQRVVDSLQTSLDAETRSRNEVL 1614

Query: 313  KKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHE 372
            +  K    DL +  +   + N++ A   +++K     Q  L++ +++ +DA  ++    E
Sbjct: 1615 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK---SLQSLLKDTQIQLDDAVRANDDLKE 1671

Query: 373  R---TKFRGHGSEASVSKHTARELSPQHKRER-LRNREFALNNENYSLSNRQVSSPSFTN 428
                 + R +  +A + +   R +  Q +R R L  +E    +E   L + Q  + S  N
Sbjct: 1672 NIAIVERRNNLLQAELEE--LRAVVEQTERSRKLAEQELIETSERVQLLHSQ--NTSLIN 1727

Query: 429  RRAAKAS---HMGVSTDSGTQETKKTEDRFVPGSSQS-----EGKKSREQPSVLSRYPPA 480
            ++    S    +    +   QE +  E++     + +     E KK ++  + L R    
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787

Query: 481  AQEHSKAWKGTSKPGTESGLKG 502
             ++  K  +       +  LKG
Sbjct: 1788 MEQTIKDLQHRLDEAEQIALKG 1809



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 92/434 (21%), Positives = 196/434 (45%), Gaps = 33/434 (7%)

Query: 35   KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
            K + +  D LL +Q  +    G  +    ++    + +L+    ++E+   ++    +KE
Sbjct: 804  KKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKE 863

Query: 95   KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKND----CTQLCLSLNEERNLTKK 150
             LE+ E   +EL+ ++  L +   +L+   +A   + ND    C QL  +  +     K+
Sbjct: 864  TLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKE 923

Query: 151  ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--E 208
            ++  LE       EL + + +L+     L  +++ L+ LTL+ V + K+  E + +N  E
Sbjct: 924  MNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE-LTLAKVEKEKHATENKVKNLTE 982

Query: 209  KL--IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
            ++  + E+  KL + KK  ++  + A     +DL++E+   ++L   + + +  +D L+ 
Sbjct: 983  EMAGLDEIIAKLTKEKKALQEAHQQA----LDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038

Query: 266  --QVENETRNKSENEKNRNQEDNKVKD---LNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
              + E + R   E  K + + D K+     ++ E +KL+ + K  +  E ++ +  SK  
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK-LKKKEFDINQQNSKIE 1097

Query: 321  DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRH--ERTKFRG 378
            D Q   L  Q K K   +++EE++ +++ ++     +VE   + LS +     ER +  G
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAER-TARAKVEKLRSDLSRELEEISERLEEAG 1156

Query: 379  HGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMG 438
              +   +  +  RE   Q  R  L   E  L +E         ++ +   + A   + +G
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDL--EEATLQHE--------ATAAALRKKHADSVAELG 1206

Query: 439  VSTDSGTQETKKTE 452
               D+  +  +K E
Sbjct: 1207 EQIDNLQRVKQKLE 1220



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 54/267 (20%), Positives = 117/267 (43%), Gaps = 15/267 (5%)

Query: 23   LSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
            L   L+EL    E+  ++ + AE EL++  ++V      N+S++ + + +   + +++  
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS- 1741

Query: 79   DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
              E++ A   CR  +EK ++       +  E+++ Q   A LE++++   ++  D     
Sbjct: 1742 --EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-- 1797

Query: 139  LSLNEERNLTKKISS-ELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
              L+E   +  K    +L+ L  +V+ELE   +     EQ   +E  K    +   + E 
Sbjct: 1798 -RLDEAEQIALKGGKKQLQKLEARVRELEGELE----AEQKRNAESVKGMRKSERRIKEL 1852

Query: 198  KYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
             Y  E++K+N   +++L  KL+   K  +     A      +L     +   L   E R 
Sbjct: 1853 TYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1912

Query: 258  KGGLDYLKQVENETRNKSENEKNRNQE 284
                  + ++  ++R+    +K  ++E
Sbjct: 1913 DIAESQVNKLRAKSRDIGAKQKMHDEE 1939



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 41/187 (21%), Positives = 91/187 (48%), Gaps = 9/187 (4%)

Query: 7    YKETASSRHLRFKLQS-LSRRLDELEEATKNLQKAEDELLD-LQDKVIQAEG--SNSSML 62
            + +  S  + + K++S L++   E+EEA +  + AE++    + D  + AE         
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778

Query: 63   AEIEVLRQRVLR-IEGKDEEIKRAEDLC-RLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
            A +E +++ + + I+     +  AE +  +  K++L++ E   REL+ E+E  QKR AE 
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838

Query: 121  EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
             K      +S+    +L     E++    ++   ++ L++KVK  +   +  ++   +  
Sbjct: 1839 VK---GMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895

Query: 181  SELEKLK 187
            S+  K++
Sbjct: 1896 SKFRKVQ 1902


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 89/397 (22%), Positives = 169/397 (42%), Gaps = 46/397 (11%)

Query: 21  QSLSRRLDELEEATK--NLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
           Q L ++L    E  K  N ++   EL   +  +++ +      LA++E   Q     E +
Sbjct: 340 QQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQ 399

Query: 79  DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
           ++E KR  +L + ++++ E E     E + EIER +    ELE+ +      +N   +L 
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERNRRQELL 458

Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
              N+E+        ++ +L+ K K LE   + L+  +  L     KL+ +     ++R+
Sbjct: 459 NQRNKEQ-------EDIVVLKAKKKTLEFELEALNDKKHQLEG---KLQDIRCRLTTQRQ 508

Query: 199 YLNEKEKENEKLIKELT---QKLEQNKKM-------NRDYTRNASNLERNDLRIED--GI 246
            +    K  E  I E+T   Q+L+++++M        +        +++N L  +    +
Sbjct: 509 EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL 568

Query: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
              L +KE  R+   D L +VE ETR+K                  QEI+    Q+K   
Sbjct: 569 KRALEAKELARQHLRDQLDEVEKETRSKL-----------------QEIDIFNNQLKELR 611

Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGEDAFL 365
            +  + +  K K+ + +     EQ +  + L  Q EE + + +++ +     V+ ED   
Sbjct: 612 EIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671

Query: 366 SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERL 402
             +  HE  K +    E SV K    E   Q  +++L
Sbjct: 672 RPRKLHEEEKLK---REESVKKKDGEEKGKQEAQDKL 705



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/168 (20%), Positives = 75/168 (44%), Gaps = 13/168 (7%)

Query: 19  KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
           ++Q  S   D L    + L+  E     L+D++ + E    S L EI++   ++      
Sbjct: 554 QVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQL------ 607

Query: 79  DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
            +E++   +  +L K+K  E E L +      +  ++++ ELEK +E   R   +  +  
Sbjct: 608 -KELREIHNKQQLQKQKSMEAERLKQ------KEQERKIIELEKQKEEAQRRAQERDKQW 660

Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
           L   ++ +  ++     E  ++K +E    +D  +K +Q    +L +L
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRL 708


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 89/397 (22%), Positives = 169/397 (42%), Gaps = 46/397 (11%)

Query: 21  QSLSRRLDELEEATK--NLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
           Q L ++L    E  K  N ++   EL   +  +++ +      LA++E   Q     E +
Sbjct: 340 QQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQ 399

Query: 79  DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
           ++E KR  +L + ++++ E E     E + EIER +    ELE+ +      +N   +L 
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERNRRQELL 458

Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
              N+E+        ++ +L+ K K LE   + L+  +  L     KL+ +     ++R+
Sbjct: 459 NQRNKEQ-------EDIVVLKAKKKTLEFELEALNDKKHQLEG---KLQDIRCRLTTQRQ 508

Query: 199 YLNEKEKENEKLIKELT---QKLEQNKKM-------NRDYTRNASNLERNDLRIED--GI 246
            +    K  E  I E+T   Q+L+++++M        +        +++N L  +    +
Sbjct: 509 EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL 568

Query: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
              L +KE  R+   D L +VE ETR+K                  QEI+    Q+K   
Sbjct: 569 KRALEAKELARQHLRDQLDEVEKETRSKL-----------------QEIDIFNNQLKELR 611

Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGEDAFL 365
            +  + +  K K+ + +     EQ +  + L  Q EE + + +++ +     V+ ED   
Sbjct: 612 EIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671

Query: 366 SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERL 402
             +  HE  K +    E SV K    E   Q  +++L
Sbjct: 672 RPRKLHEEEKLK---REESVKKKDGEEKGKQEAQDKL 705



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/168 (20%), Positives = 75/168 (44%), Gaps = 13/168 (7%)

Query: 19  KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
           ++Q  S   D L    + L+  E     L+D++ + E    S L EI++   ++      
Sbjct: 554 QVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQL------ 607

Query: 79  DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
            +E++   +  +L K+K  E E L +      +  ++++ ELEK +E   R   +  +  
Sbjct: 608 -KELREIHNKQQLQKQKSMEAERLKQ------KEQERKIIELEKQKEEAQRRAQERDKQW 660

Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
           L   ++ +  ++     E  ++K +E    +D  +K +Q    +L +L
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRL 708


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 100/511 (19%), Positives = 212/511 (41%), Gaps = 56/511 (10%)

Query: 7   YKETASSRHLRFKLQSLSRRLD-----------ELEEATKNLQKAEDELLDLQDKVIQAE 55
           Y+ T ++  L+ K   L  +L             ++E  + L++A+  L  +Q   +Q E
Sbjct: 176 YRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 235

Query: 56  GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMK-------EKLEEEENLTRELKS 108
                M  + E LR++  +I  ++E++ R E+  R  +       EK+  +E   RE + 
Sbjct: 236 -----MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290

Query: 109 EIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESS 168
           E+   +K + E +KL E   + +    ++     + R   +K+  + E L  + K++   
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350

Query: 169 EDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEK-ENEKLIKELTQKLEQNKKMNRD 227
           E ++   E+ +  + E+L+        + K   ++EK + E+ I+E  +K+ + ++  R+
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMRE 410

Query: 228 YTRNASNLERN--DLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQED 285
                   E N  +   ++     LP ++ +     +  K  E E +   + EK R+QE+
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL---WEQEKMQEQEEKIWEQEEKIRDQEE 467

Query: 286 --NKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
              + K + ++ EK++ Q       EE+++  + K  D Q+  + EQ++      +L E 
Sbjct: 468 MWGQEKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWD-QEERMWEQDE------RLREK 519

Query: 344 KLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLR 403
           + ++++QK++   E                 K R         K T  +     + ER+R
Sbjct: 520 EERMREQKKMWQQE----------------EKMREEKKTQEQEKKTWDQEEKMREEERMR 563

Query: 404 NREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSE 463
            RE  +  E   +  ++        +   +   M    +   ++ +K  ++      Q E
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623

Query: 464 GKKSREQPSVLSRYPPAAQE-HSKAWKGTSK 493
             K +EQ  ++       QE   K W+   K
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 66/348 (18%), Positives = 158/348 (45%), Gaps = 26/348 (7%)

Query: 26  RLDELEEATKNLQKA--EDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIK 83
           RL E EE  +  +K   ++E +  ++++ + E     M  E E +R++  +++ ++E + 
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIRERE---KKMREEEETMREQEEKMQKQEENMW 423

Query: 84  RAEDL----CRL--MKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
             E+      RL   KEKL E+E    +++ + E++ ++  ++   EE + + K    Q 
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQE----KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ- 478

Query: 138 CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
                + R    ++  + E +R + +++   E+R+ + ++ L  + E+++     +  E 
Sbjct: 479 ----EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE 534

Query: 198 KYLNEKE-KENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESR 256
           K   EK+ +E EK   +  +K+ + ++M     +     E    + E         +E  
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594

Query: 257 RKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEI-----EKLKTQIKHFESLEEE 311
            K      K  E E +   + EK   QE+       +E+     EK++ Q +     EE+
Sbjct: 595 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654

Query: 312 LKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
           +++ + K  + ++    ++ K +    +++  + ++++Q+E   G+ E
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEE 702



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/206 (17%), Positives = 100/206 (48%), Gaps = 6/206 (2%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
           K+T       +  +   R  + + E  K +++ E+ + + ++K+ + E     M  + E 
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE---EKMREQEEK 596

Query: 68  LRQRVLRIEGKDEEIKRAEDLCRLMKE--KLEEEENLTRELKSEIERLQKRMAELE-KLE 124
           + ++  +++ ++E++   E+     +E  K++E+E +  E + +++  +++M E E K+ 
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656

Query: 125 EAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
           E   + +    ++     + R   +K+  + E +R + +++   E+++   E+ +  + E
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEE 716

Query: 185 KLKSLTLSFVSERKYLNEKEKENEKL 210
           K+         E +  ++KEK  E+L
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQERL 742



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 25/119 (21%), Positives = 68/119 (57%), Gaps = 10/119 (8%)

Query: 28  DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
           ++++E  + + + E+++ + ++K+ + E     M  + E +R++  +++G++E+++  E+
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQE---EKMQGQEEKMREQEEKMQGQEEKMREQEE 695

Query: 88  LCRLMKEKL--EEEENLTRELK----SEIERLQKRMAEL-EKLEEAFSRSKNDCTQLCL 139
             R  +EK+  +EE+   +E K     E+   ++R+ +  EK++E     +  C++ CL
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCL 754


>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
          Length = 1113

 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 140/647 (21%), Positives = 266/647 (41%), Gaps = 63/647 (9%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
            K ++ +  L    + L + ++EL      L+ +E  + DL   + + E +  +  AEI  
Sbjct: 462  KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITK 521

Query: 68   LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
            LR RV              DL     + L+ E +  R +++E E L+ +M E +K+ E  
Sbjct: 522  LRSRV--------------DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL 567

Query: 128  SRSKNDCTQLCLSLNEERNLTK----KISSELEMLRVKVKELESSEDRLDKTEQSLAS-- 181
             +   + TQL           +    ++  E+   R+++KEL+  +D+ D   + L +  
Sbjct: 568  RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627

Query: 182  ---ELEKLKSLTLSFVSER-KYLNEKEKENEKLIKELTQKLEQNKKMNRDY---TRNASN 234
               ELEK+K +     SER + + + ++E ++L+ E+     +   ++ +Y    RN  N
Sbjct: 628  SDLELEKVKLVNAG--SERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRN 685

Query: 235  LERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE----NEKNRNQEDNKVKD 290
                     + +   L S +S  +   + LK +E    +  +     +K    +  ++  
Sbjct: 686  KSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDA 745

Query: 291  LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
            L  +I+ L+  + +    +  LK+ KSK +       +E+NK   +A +LE ++ Q ++ 
Sbjct: 746  LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNK---MAGELEVLRSQERRL 802

Query: 351  KE-LENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT--ARELSPQHKRERLRNREF 407
            KE + N EV  + A L      +  + +   S     +HT   +EL           +  
Sbjct: 803  KEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPR 862

Query: 408  ALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKS 467
             L   + + S+  V S   T   A+  SH   ST + T +   T D  +    Q      
Sbjct: 863  LLQPASVTRSHSNVPSSQST---ASFLSHH--STKANTLKEDPTRD--LKQLLQELRSVI 915

Query: 468  REQPSV-LSRYPPAAQEHSKAWKGTSKPG-----TESGLKGKV-EKTTRTFSDTTHGSVP 520
             E+P+V LS+     +E  +   G  +       TES L+  +  ++  +  D+T GS  
Sbjct: 916  NEEPAVSLSK----TEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKS 971

Query: 521  SDPLGR------ADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSS 574
            S+ L R      A    D S    F          S      +S     + +L +S    
Sbjct: 972  SETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEG 1031

Query: 575  SEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFST 621
            S G +   ++A  + + +S  +S++P +     +CR  +N L+   T
Sbjct: 1032 SIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQT 1078



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 86/398 (21%), Positives = 170/398 (42%), Gaps = 54/398 (13%)

Query: 16  LRFKLQSLSRRLDELEEATKNLQKAEDELLD-LQDKVIQAEGSN---SSML----AEIEV 67
           L+ KLQ +    D + +  +   +++++L + LQ+ V + E +      ML     +IE 
Sbjct: 115 LQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQ 174

Query: 68  LRQRVLRIEGKDEEIKRA-EDLCRLMKEKLEEEENLT---------------RELKSEIE 111
           LR+ +L  EG  +EI+    D      +K+ E ++++               REL +EI 
Sbjct: 175 LRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEIS 234

Query: 112 RLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDR 171
            L+ R+  +E   EA      +  +L L  +++R   +++ SE E   V++  L      
Sbjct: 235 YLKGRIFPVEDQLEALKSESQNKIELLLQQHQDR--IEQLISEHE---VEITGLTEKASS 289

Query: 172 LDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRN 231
                 S+ S++E ++    +   +      +  + E  + +L  +L + K+M  D T  
Sbjct: 290 ARSQANSIQSQMEIIQEQARN---QNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEE 346

Query: 232 ASNLERNDLRIEDGISSTLPSKE--SRRKGGLDYLKQVENETRNKSENEKNRNQEDNK-- 287
              LE+  +     ++     ++  S+  G LD   Q      +K E E +  +E NK  
Sbjct: 347 ---LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRL 403

Query: 288 ----------VKDLNQEIEKLKTQIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLL 336
                     +  L +E++    +++  E+L   LK +KS+    ++    + Q KN+ L
Sbjct: 404 WDRDTGNSITIDHLRRELDNRNMEVQRLEAL---LKALKSECQGQMERQMAAIQGKNESL 460

Query: 337 ASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
             ++  +  Q++  KE+    VE   A   +    ERT
Sbjct: 461 -EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT 497



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 83/370 (22%), Positives = 160/370 (43%), Gaps = 42/370 (11%)

Query: 20  LQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSN--SSMLAEIEVLRQRVLRIEG 77
           LQ +   L + EEA+       D +  L  + + +  S     +  EI  L+ R+  +E 
Sbjct: 186 LQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245

Query: 78  KDEEIKRAED--LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
           + E +K      +  L+++  +  E L  E + EI  L       EK   A S++ +  +
Sbjct: 246 QLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT------EKASSARSQANSIQS 299

Query: 136 QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
           Q+ +   + RN       +L  L   V +L S      +  +    ELEK   L  S ++
Sbjct: 300 QMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELT 359

Query: 196 ERKYLNEK--------EKENEKLI-------KELTQKLEQNKKMNRDYTRNASNLERNDL 240
           E +   ++        + + +KL+       KEL+ + EQNK++    T N+  ++    
Sbjct: 360 EARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR 419

Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENE----KNRNQEDNKVKDLNQEIE 296
            +++       + E +R   L  LK +++E + + E +    + +N+   KV  L  ++E
Sbjct: 420 ELDN------RNMEVQRLEAL--LKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLE 471

Query: 297 KLKTQI-KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLL-ASQLEEIKLQIK---KQK 351
             K  + K  E L  +   ++S    + D   S Q K + + A+  E  KL+ +   K +
Sbjct: 472 STKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQ 531

Query: 352 ELENGEVEGE 361
           EL++ + EG+
Sbjct: 532 ELQHLKNEGD 541



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 74/402 (18%), Positives = 174/402 (43%), Gaps = 36/402 (8%)

Query: 79  DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
           +E   + +DL R + E  E  E     L+  +  LQ ++ E++   +A +  +   +Q  
Sbjct: 81  EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ-- 138

Query: 139 LSLNEERNLTKKISSELEMLR-VKVKELESSEDRLDKTEQSLASE---LEKLKSLTLSFV 194
            S  + RN  +    ELE  + +K   L+ S  ++++  + + S    L++++S+ + F 
Sbjct: 139 -SQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFE 197

Query: 195 -SERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
            +  K + E +  +    + L   +    K+ R+     S L+     +ED + +     
Sbjct: 198 EASGKKICEHDSMSTLHFRSLGSAIS---KILRELDTEISYLKGRIFPVEDQLEAL--KS 252

Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
           ES+ K  ++ L Q     +++   E+  ++ + ++  L ++    ++Q     S++ +++
Sbjct: 253 ESQNK--IELLLQ-----QHQDRIEQLISEHEVEITGLTEKASSARSQAN---SIQSQME 302

Query: 314 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
            ++ +  +    Y+ + +  +   SQL     + K+  E +  E+E +    +S+    R
Sbjct: 303 IIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEAR 362

Query: 374 TKFRGHGSEA-SVSKHTARELSPQHKRERLRNREFALNNE-NYSLSNRQVSSPSFTNRRA 431
           T+      E+ ++     + L+  HKRE    +E +L  E N  L +R   +       +
Sbjct: 363 TERDQFSQESGNLDDQLQKLLADLHKRE----KELSLEKEQNKRLWDRDTGN-------S 411

Query: 432 AKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSV 473
               H+    D+   E ++ E       S+ +G+  R+  ++
Sbjct: 412 ITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAI 453


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 85/424 (20%)

Query: 13   SRHLRFKLQSLSRRLDELE----EATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
            S  L  ++  L R++++L+    +A + L+K E E+  L++ ++ A       ++    L
Sbjct: 838  SEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL 897

Query: 69   RQRVLRIEGK-DEEIKRAEDLCRLMKEKLEEEENLTR---ELKSE-------IERLQKRM 117
               +   +G   +  +  + L   +KE+ E++E L R   E+++E       IE+LQK M
Sbjct: 898  ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957

Query: 118  AEL------------EKLEEAFSRSKNDCTQLCLSLNEE-------RNLTKKISSELEML 158
            A++             +L+E   +++ +  ++   L E+       R    K+  E+ ++
Sbjct: 958  ADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLM 1017

Query: 159  RVKVKELESSEDR-------LDKTEQSLASELE------------------KLKSLTLSF 193
              ++++ + ++D        L++T + L  ELE                  K+  L +  
Sbjct: 1018 EEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL 1077

Query: 194  VSERK---YLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTL 250
              ER     L+E+   + + +++L  +L Q +   +D   +  +LER +  ++  I    
Sbjct: 1078 EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137

Query: 251  PSKESRRKGGLDYLK--------QVENETRNKSENEKNRNQEDNKVKDLNQEIE------ 296
             S  S ++G +  ++        ++E+E R+++  + +  + + KVK+L  +++      
Sbjct: 1138 GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197

Query: 297  ---------KLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
                     +LK   +  E  EEE+ +++S    LQ     + + N+ L  QL  +K  +
Sbjct: 1198 TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257

Query: 348  KKQK 351
            + +K
Sbjct: 1258 RLKK 1261



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 84/360 (23%), Positives = 166/360 (46%), Gaps = 43/360 (11%)

Query: 28   DELEEATKNLQ-------KAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG--- 77
            + +EEATKN++        +E +    + +V   +  N  +    E L +RV +++    
Sbjct: 794  ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853

Query: 78   --KDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA---ELEKLEEAFSRSKN 132
              K +E K  E L +   E  + EE L    K E E +  R A   ELE  +   S++  
Sbjct: 854  DLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913

Query: 133  DCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
            +  QL   L EE       S + E LR    E+E+    L KT + L  E+  +   + +
Sbjct: 914  EQKQLSEKLKEE-------SEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966

Query: 193  FVSE-RKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRI-EDGISSTL 250
               E +  L+E +++N + + E+ ++L++ K +  + +R  +   ++++R+ E+ +    
Sbjct: 967  STLELQNQLDEYKEKNRRELAEMQRQLKE-KTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025

Query: 251  PSKE---SRRKGGLDYLKQVENETRNKSENEKNRN----QEDNKVKDLNQEIE------- 296
             +++   ++R+     LK +E E   KS  + +R+    Q ++KV  L  E+E       
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085

Query: 297  ----KLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE 352
                ++    +  E L  EL + ++   DL+ + +S + +NK L S++  ++   +  KE
Sbjct: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 96/428 (22%), Positives = 198/428 (46%), Gaps = 54/428 (12%)

Query: 29   ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDL 88
            +L+   KN Q  ++E   ++  + +    ++  + E   L+QR+   EG  E  K  E+L
Sbjct: 629  QLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG--ELRKNLEEL 686

Query: 89   CRLMKEKLEEEENLTRELKSEIERLQ------KRMAELEK--LEEAFSRSKNDCTQLCLS 140
             ++  E+ E+ +   R+L+ ++  +       KR  + EK  L E   ++K D   L ++
Sbjct: 687  FQVKMER-EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745

Query: 141  LNEERNLTKKISSELEMLRVKVKELESSEDR-LDKTEQSLASELEKLK------SLTLSF 193
              E+ +L +K   EL  L+  +KE  SS D+ +DK ++   +EL+ L+      +  +  
Sbjct: 746  KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805

Query: 194  VSERKYLNEKEKENEKLIKELTQKLEQNKKM---NRDYTRNASNLERNDLRIEDGISSTL 250
            ++ R   +E+++   ++  +L Q  E+N+K+   + +  R  + L+R   +IED     L
Sbjct: 806  LASRSNTSEQDQAGTEMRVKLLQ--EENEKLQGRSEELERRVAQLQR---QIED-----L 855

Query: 251  PSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV----KDLNQEIE----KLKTQI 302
               E++ K   + LK+ E E R   E   +  +E+ +     + L  E+E     L    
Sbjct: 856  KGDEAKAK---ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912

Query: 303  KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ---IKKQKELENGEVE 359
            +  + L E+LK+   +   L+      +N+   L   +E+++ +   I +       E++
Sbjct: 913  QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ 972

Query: 360  GEDAFLSSKGRHE----RTKFRGHGSEASVSKHTARELSPQHK--RERLRNREFALNNEN 413
             +      K R E    + + +    EA  S+ TA ++  + +   E LR+ + A   ++
Sbjct: 973  NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA---QD 1029

Query: 414  YSLSNRQV 421
             +L+ RQ+
Sbjct: 1030 EALTKRQL 1037



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 86/420 (20%), Positives = 169/420 (40%), Gaps = 42/420 (10%)

Query: 21   QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML--------AEIEVLRQRV 72
            Q L   L   EE    L+K E EL  L+  + +   S+   +        AE++ LR+ V
Sbjct: 737  QDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESV 796

Query: 73   LRIEGKDEEIKRAEDLCRLMKEKLEEE---ENLTRELKSEIERLQKRMAELEKLEEAFSR 129
                  +E  K  E L        +++   E   + L+ E E+LQ R  ELE+      R
Sbjct: 797  ------EEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQR 850

Query: 130  SKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSL 189
               D   L     + +   KK   E+  L   +      E       ++L +ELE  +  
Sbjct: 851  QIED---LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907

Query: 190  TLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISST 249
                  E+K L+EK       +KE +++ EQ +++  +      +L +   +++  ++  
Sbjct: 908  LSQTTQEQKQLSEK-------LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960

Query: 250  LPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLE 309
            +   E+ R   L+   Q++ E + K+  E    Q   K K L  E  +L         ++
Sbjct: 961  V---EASRTSTLELQNQLD-EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-----KMQ 1011

Query: 310  EELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENG------EVEGEDA 363
            +E++ M+ +  D Q        K +LL   L++++ +++ +  L++       ++E + +
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071

Query: 364  FLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSS 423
             L  +   ER          S S+    +L  +  +ER   ++   +  +    N+ + S
Sbjct: 1072 QLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKS 1131



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 77/348 (22%), Positives = 156/348 (44%), Gaps = 41/348 (11%)

Query: 23   LSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK--DE 80
            L + L+EL +     ++ + E+ DLQD++       S M  E++  ++   R +G   +E
Sbjct: 679  LRKNLEELFQVKMEREQHQTEIRDLQDQL-------SEMHDELDSAKRSEDREKGALIEE 731

Query: 81   EIKRAEDLCRLMKEKLEEEENLTRELKSEI--------ERLQKRMAELEKLEE------- 125
             ++  +DL  L+  K EE+E+L R+ + E+        E +     E++KL+E       
Sbjct: 732  LLQAKQDLQDLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ 790

Query: 126  AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
            A   S  + T+    L    N +++  +  EM   +VK L+   ++L    + L   + +
Sbjct: 791  ALRESVEEATKNVEVLASRSNTSEQDQAGTEM---RVKLLQEENEKLQGRSEELERRVAQ 847

Query: 186  LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
            L+        +     E  K+ E  I++L + L   +K  ++       LE N+L    G
Sbjct: 848  LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE-NELEAAQG 906

Query: 246  ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
              S    ++ +        ++++ E+  K +  + +N+ +N+   L + IEKL+   K  
Sbjct: 907  NLSQTTQEQKQLS------EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ---KEM 957

Query: 306  ESLEEELKKMKSKNNDLQDNYLSEQNKNKL--LASQLEEIKLQIKKQK 351
              + E  +    +  +  D Y  E+N+ +L  +  QL+E  L+ +K +
Sbjct: 958  ADIVEASRTSTLELQNQLDEY-KEKNRRELAEMQRQLKEKTLEAEKSR 1004



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 72/284 (25%), Positives = 129/284 (45%), Gaps = 56/284 (19%)

Query: 9    ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV- 67
            E   SR    K+Q   R +   EE  ++ Q+A+DE L  +  + Q        L ++E  
Sbjct: 999  EAEKSRLTAMKMQDEMRLM---EEELRDYQRAQDEALTKRQLLEQT-------LKDLEYE 1048

Query: 68   LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL--EKLEE 125
            L  +    + +   +K+ ED    ++ +LEEE N +  L   I R +++M +L  E L+E
Sbjct: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108

Query: 126  AFSRSKNDCTQLCLSLNEERNLTKKI-------SSELEMLRVKVK-ELESSEDRLDKTEQ 177
              +R   +C ++ L   + ++L  +I        S  E L V+++  +   EDRL+  E+
Sbjct: 1109 RAARQDLECDKISLE-RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167

Query: 178  SLAS------ELE-KLKSLTLSFVSE------------------RKYLNEKEKENEKL-- 210
              A+       LE K+K L +    E                  ++ + E E+E ++L  
Sbjct: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227

Query: 211  -IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
              K+L ++LE+   MN ++ +   N  + DLR++      LPSK
Sbjct: 1228 SKKKLQRELEEQMDMN-EHLQGQLNSMKKDLRLK-----KLPSK 1265



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 84/346 (24%), Positives = 157/346 (45%), Gaps = 63/346 (18%)

Query: 82  IKRAEDLCRLMKEKLEEE--ENLTRELKSEIERLQKRMAEL--EKLEEAFSRSKNDC--- 134
           +K  ++L +   E+  ++   N  +E  ++ +   KR   L  EK++   SR+       
Sbjct: 540 LKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGN 599

Query: 135 TQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFV 194
            Q C S +E ++L ++ S     L ++V EL+       K +Q++  E E++++   +  
Sbjct: 600 NQACNSTSEVKDLLEQKSK----LTIEVAELQRQLQLEVKNQQNIKEERERMRA---NLE 652

Query: 195 SERKYLNEKEKENEKLIK-------ELTQKLEQ--NKKMNRD-YTRNASNLERNDLRIED 244
             R   NEK +EN  L +       EL + LE+    KM R+ +     +L+     + D
Sbjct: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712

Query: 245 GISSTLPSKESRRKGGL-DYLKQVENETRN----KSENE---KNRNQE--------DNKV 288
            + S   S E R KG L + L Q + + ++    K E E   + R +E          +V
Sbjct: 713 ELDSAKRS-EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771

Query: 289 KDLNQEIEKLKTQIKH-----FESLEEELKKMK----SKNNDLQDNYLSE------QNKN 333
              +QE++KLK Q         ES+EE  K ++      N   QD   +E      Q +N
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831

Query: 334 KLLASQLEEIKLQIKK-QKELENGEVEGEDAFLSSKGRHERTKFRG 378
           + L  + EE++ ++ + Q+++E  +++G++A    K +    K+ G
Sbjct: 832 EKLQGRSEELERRVAQLQRQIE--DLKGDEA----KAKETLKKYEG 871


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 94/436 (21%), Positives = 190/436 (43%), Gaps = 63/436 (14%)

Query: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQA------ 54
            +A+ T  K+     H +  L  L    D++   TK   K E ++ DL+  + Q       
Sbjct: 989  IAKLTKEKKALQEAHQQ-ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047

Query: 55   -EGSNSSMLAEIEVLRQRVLRIEGK----DEEIKRAEDLCRLMKEKLEEEENLTRELKSE 109
             E +   +  ++++ ++ ++ +E      DE +K+ +     +  ++E+E+ L  +L+ +
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKK 1107

Query: 110  IERLQKRMAEL--------------EKLEEAFSRSKND----------CTQLCLSLNEER 145
            ++ LQ R+ EL              EKL    SR   +           T + + +N++R
Sbjct: 1108 LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167

Query: 146  NLT-KKISSELE-----------MLRVK----VKELESSEDRLDKTEQSLASELEKLKSL 189
                +K+  +LE            LR K    V EL    D L + +Q L  E  + K  
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227

Query: 190  TLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL--ERNDLRIEDG-I 246
                 S  + + + +   EK+ + L  ++ +++    +  R+ ++L  +R  L+ E+G +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL 1287

Query: 247  SSTLPSKES----RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI 302
            S  L  KE+      +G L Y +Q+E+  R   E  K +N   + ++    + + L+ Q 
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347

Query: 303  KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGE 361
            +     + EL+++ SK N     + ++   + +    +LEE K ++ ++ +     VE  
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407

Query: 362  DAFLSSKGRHERTKFR 377
            +A  SS    E+TK R
Sbjct: 1408 NAKCSSL---EKTKHR 1420



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 91/431 (21%), Positives = 195/431 (45%), Gaps = 32/431 (7%)

Query: 1    MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
            M  +   K    S     ++ S+      L+EA   L+K+E    +L++K++       S
Sbjct: 830  MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEA---LEKSEARRKELEEKMV-------S 879

Query: 61   MLAEIEVLRQRVLRIEGKDEEIKRAEDLC-RLMKEKLEEEENLTRELKSEIERLQKRMAE 119
            +L E   L+   L+++ + + +  AE+ C +L+K K++ E  + +E+   +E  ++  AE
Sbjct: 880  LLQEKNDLQ---LQVQAEQDNLADAEERCDQLIKNKIQLEAKV-KEMNERLEDEEEMNAE 935

Query: 120  LEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSL 179
            L   +    + +++C++L   +++      K+  E      KVK L      LD+    L
Sbjct: 936  LTAKKR---KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992

Query: 180  ASELEKLKSLTLSFV----SERKYLNEKEKENEKL---IKELTQKLEQNKKMNRDYTRNA 232
              E + L+      +    +E   +N   K   KL   + +L   LEQ KK+  D  R  
Sbjct: 993  TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1052

Query: 233  SNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN-RNQEDNKVKDL 291
              LE  DL++       L + + +    L       N    + E+E+   +Q   K+K+L
Sbjct: 1053 RKLE-GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111

Query: 292  NQEIEKLKTQIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
               IE+L+ +++   +   +++K++S  + +L++  +SE+ +    A+ + +I++  K++
Sbjct: 1112 QARIEELEEELEAERTARAKVEKLRSDLSRELEE--ISERLEEAGGATSV-QIEMNKKRE 1168

Query: 351  KELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALN 410
             E +    + E+A L  +      + +   S A + +        + K E+ ++ EF L 
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS-EFKLE 1227

Query: 411  NENYSLSNRQV 421
             ++ + +  Q+
Sbjct: 1228 LDDVTSNMEQI 1238



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 116/548 (21%), Positives = 231/548 (42%), Gaps = 79/548 (14%)

Query: 17   RFKLQS----LSRRLDELEEATKNLQKAE----DELLDLQDKVIQAEGSNSSMLAEIEVL 68
            R KLQ+    LSR+LDE E     L + +     +L DL+ ++ +   + +++   ++  
Sbjct: 1277 RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336

Query: 69   RQRV-LRIEGKDEEIKRAEDLCRLMK---------------------EKLEE-EENLTRE 105
            R    L  E  +EE +   +L R++                      E+LEE ++ L + 
Sbjct: 1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396

Query: 106  LKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN-----------EERNLTKKISSE 154
            L+   E ++   A+   LE+   R +N+   L + +            ++RN  K ++  
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456

Query: 155  LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL---I 211
             +       ELESS+    K  +SL++EL KLK+   ++    ++L   ++EN+ L   I
Sbjct: 1457 KQKYEESQSELESSQ----KEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEI 1509

Query: 212  KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR----KGGLDYLKQV 267
             +LT++L  + K   +  +    LE   + ++  +     S E       +  L++  Q+
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF-NQI 1568

Query: 268  ENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI-KHFESLEEELKKMKSKNNDLQDNY 326
            + E   K   EK+   E  K   L + ++ L+T +     S  E L+  K    DL +  
Sbjct: 1569 KAEIERKLA-EKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626

Query: 327  LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER---TKFRGHGSEA 383
            +   + N++ A   +++K     Q  L++ +++ +DA  ++    E     + R +  +A
Sbjct: 1627 IQLSHANRMAAEAQKQVK---SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683

Query: 384  SVSKHTARELSPQHKRER-LRNREFALNNENYSLSNRQVSSPSFTNRRA---AKASHMGV 439
             + +   R +  Q +R R L  +E    +E   L + Q  + S  N++    A  S +  
Sbjct: 1684 ELEE--LRAVVEQTERSRKLAEQELIETSERVQLLHSQ--NTSLINQKKKMDADLSQLQT 1739

Query: 440  STDSGTQETKKTEDRFVPGSSQS-----EGKKSREQPSVLSRYPPAAQEHSKAWKGTSKP 494
              +   QE +  E++     + +     E KK ++  + L R     ++  K  +     
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799

Query: 495  GTESGLKG 502
              +  LKG
Sbjct: 1800 AEQIALKG 1807



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 57/273 (20%), Positives = 120/273 (43%), Gaps = 29/273 (10%)

Query: 23   LSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
            L   L+EL    E+  ++ + AE EL++  ++V      N+S++ + + +   + +++  
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ-- 1738

Query: 79   DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
              E++ A   CR  +EK ++       +  E+++ Q   A LE++++   ++  D     
Sbjct: 1739 -TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-- 1795

Query: 139  LSLNEERNLTKKISS-ELEMLRVKVKELESS----EDRLDKTEQSLASELEKLKSLTLSF 193
              L+E   +  K    +L+ L  +V+ELE+     + R  ++ + +     ++K LT   
Sbjct: 1796 -RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT--- 1851

Query: 194  VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
                 Y  E++++N   +++L  KL+   K  +     A      +L     +   L   
Sbjct: 1852 -----YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1906

Query: 254  ESRRKGGLDYLKQVENETRNKSEN--EKNRNQE 284
            E R     D  +   N+ R KS +   K  N+E
Sbjct: 1907 EER----ADIAESQVNKLRAKSRDIGTKGLNEE 1935


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 103/482 (21%), Positives = 201/482 (41%), Gaps = 79/482 (16%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM------ 61
           + T     L  K++ ++++L   E   +++ + E E L+++ + I  E  N  +      
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAEN-DRDILRREQEQLNVEKRQIMEECENLKLECSKLQ 361

Query: 62  -----LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRE--LKSEIERLQ 114
                 ++    ++R+L      EE+ R +      + ++    +L ++  L  +  +L+
Sbjct: 362 PSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLK 421

Query: 115 KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK-------ISSELEMLRVKVKELES 167
            R+  LEK +   S+ K +     L LN E  + K        + SEL  LR+ ++  E 
Sbjct: 422 MRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQ 481

Query: 168 SEDRLDKTEQSLASELEKL----KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKK 223
             ++    +++L +E+E+L    +  T   +  +  L++++ E + +I +L Q L   KK
Sbjct: 482 ELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKK 541

Query: 224 M-------NRDYTRNA---------SNLERNDLRIE------------DGISSTLPSKES 255
                     D T+           S +  NDL +             D ++ +  S  S
Sbjct: 542 RVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVS 601

Query: 256 RRKGGLDY----------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
            +K  L+           L ++ NE       + N N +D  +K+   E+  LK  +   
Sbjct: 602 IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661

Query: 306 ESLEEELKK----MKSKNNDLQDNYLSEQNKNKL---LA--SQLEEIKLQIKKQKELENG 356
           E L E LKK    +K +N  L      E  +++L   LA  +QL   K  I +  ++E G
Sbjct: 662 EQLNENLKKVAFDVKMENEKLV--LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKG 719

Query: 357 EVEGEDAFLSSKGRHERTKFRGHGSEASVSKH---TARELSPQH--KRERLRNREFALNN 411
           E+E E  +   +   E  K+     E S +++   +A +L  +H  K  + ++ E A   
Sbjct: 720 EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK 779

Query: 412 EN 413
           +N
Sbjct: 780 KN 781



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 104/446 (23%), Positives = 193/446 (43%), Gaps = 69/446 (15%)

Query: 12  SSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQR 71
           +++H+      LS++ +E +     + K + +L D + +V Q E     +  E++V +++
Sbjct: 507 ATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK 563

Query: 72  VLRIEGKDEEIKRAEDLCRLMKEKLEEE-ENLTRELKSEIER---LQKRMAELEKL---- 123
           +++ E    ++        L K+KLE++ ENL  +L    E    +QK   EL++     
Sbjct: 564 LIQSEVALNDL-------HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616

Query: 124 EEAFSRSKNDCTQLCLSLNEERN------LTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
           EE  SR +N+  Q   SLN++ N      L K+  +E+  L+  + ELE   + L K   
Sbjct: 617 EEELSRIRNELMQ---SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673

Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            +  E EKL    L+    R  L E    N +L  E    +E  K    +        ++
Sbjct: 674 DVKMENEKL---VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK 730

Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEK 297
             L   +    T+    + R      L Q+E+E   K   +K     D ++ +L + IE+
Sbjct: 731 RLLEEANKYEKTIEELSNARNLNTSAL-QLEHEHLIKLNQKK-----DMEIAELKKNIEQ 784

Query: 298 LKTQIKHFE-----SLEEE-------------LKKMKSKNNDLQ---DNYLSEQNKNKLL 336
           + T  K  +     SLEE+             ++K+K +++ LQ   D Y     KN++L
Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844

Query: 337 ASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT--ARELS 394
              +EE    +   KE EN  ++ E      + R E+++        ++   T  A E+S
Sbjct: 845 RQTIEEKDRSLGSMKE-ENNHLQEE----LERLREEQSRTAPVADPKTLDSVTELASEVS 899

Query: 395 -----PQHKRERLRNREFALNNENYS 415
                 +H  E +++ +  + ++N S
Sbjct: 900 QLNTIKEHLEEEIKHHQKIIEDQNQS 925



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 108/490 (22%), Positives = 212/490 (43%), Gaps = 76/490 (15%)

Query: 9    ETASSRHLRFKLQSLSRRLDELE-EATKNLQKAEDELLDLQDKVI--QAEGSNSSMLAEI 65
            E++     R  +Q+LSR + E + E     QK +  L  LQ      +A G NS+   E+
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEEL 1207

Query: 66   EVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEE 125
               R ++       +++K+ E+  + +   ++  ++ + +L+ E+ +LQ   A++    +
Sbjct: 1208 LQERDKL------KQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ---AQVLVDSD 1258

Query: 126  AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
              S+ + D T L  S  +     K    EL  ++  + +L +++D L      ++ +L  
Sbjct: 1259 NNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSS 1318

Query: 186  LKSLT-LSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
               LT  S    R   +E   E+ +L++   Q+LE+ +K  ++       L+ N+ R+ D
Sbjct: 1319 ASLLTPQSAECLRASKSEVLSESSELLQ---QELEELRKSLQEKDATIRTLQENNHRLSD 1375

Query: 245  GISST--LPSKESRR--------KGGLDYLKQVENET----RNKSENEKNRNQE-DNKVK 289
             I++T  L  KE  +        K   D L+++  E     + KS+   + N+   NKV 
Sbjct: 1376 SIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVN 1435

Query: 290  D---LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ 346
            +   L Q +  LK +I     LE ++ K+K +N  + + Y  ++ + + L     +  + 
Sbjct: 1436 ENELLRQAVTNLKERIL---ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMM 1492

Query: 347  IKKQ------------------KELENGEVEGEDAFLSS-KGRHERTK-FRGHGSEA--S 384
            ++++                  KE E G+    +  L++ K   E+T  F+    +   +
Sbjct: 1493 LREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552

Query: 385  VSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSG 444
            + +      + Q++ +RLR++EF  N E   L N                 H+  S DS 
Sbjct: 1553 LKQKQMENTALQNEVQRLRDKEFRSNQELERLRN-----------------HLLESEDSY 1595

Query: 445  TQETKKTEDR 454
            T+E    EDR
Sbjct: 1596 TREALAAEDR 1605



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 66/288 (22%), Positives = 132/288 (45%), Gaps = 29/288 (10%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVI----QAEGSNSSMLA 63
            K  A  + L+ K Q  +  L++L  A K++Q+        +D+V+    Q +  N+++  
Sbjct: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565

Query: 64   EIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL 123
            E++ LR         D+E +  ++L RL    LE E++ TRE  +  +R  K   ++  L
Sbjct: 1566 EVQRLR---------DKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVL 1616

Query: 124  EEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL 183
            EE          +L  S N   N + + S ++E L+   ++L     + D+T   L+   
Sbjct: 1617 EE----------KLVSSSNAMENASHQASVQVESLQ---EQLNVVSKQRDETALQLSVSQ 1663

Query: 184  EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIE 243
            E++K   LS  + +  L   ++E + +    + +LE+ K++  ++ +NA NLE   + ++
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAM---YSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720

Query: 244  DGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDL 291
            + +     + +S  +       + E     K +NE  +   D+  K L
Sbjct: 1721 ECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 85/430 (19%), Positives = 175/430 (40%), Gaps = 61/430 (14%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
            K   S   L  ++  L+   + LEE  K+ QK  ++    + +++Q+       + E   
Sbjct: 886  KTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRY 945

Query: 68   LRQRV------LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEI-ERLQKRMAEL 120
              +++      L +E KDEEIK  +     +K +L EE    +   S+I +  + +   +
Sbjct: 946  QHEQMNATHTQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI 1004

Query: 121  EKLEEAFSRSKNDCTQLCLSLNE---------ERN--LTKKI--------SSELEMLRVK 161
            E   E    SK +  +L   + E         E+N  LTK+I            ++++ K
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064

Query: 162  VKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK----YLNEKEKENEKLIKE---- 213
              E+++   R+  T  S   ++  L+    ++  ER+     LNEK +EN  L  E    
Sbjct: 1065 DLEIQALHARISST--SHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122

Query: 214  ----------LTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDY 263
                      L +  ++NKK++  +  +  ++ R  ++    +S  +  K+         
Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQ---NLSRIIREKDIEIDALSQK 1179

Query: 264  LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQ 323
             + +    +  S   +      N+ ++L QE +KLK Q+          KKM+     + 
Sbjct: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV----------KKMEEWKQQVM 1229

Query: 324  DNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEA 383
                + Q+++  L  +L +++ Q+    +  N +++ +   L        TK +  G E 
Sbjct: 1230 TTVQNMQHESAQLQEELHQLQAQVLVDSD-NNSKLQVDYTGLIQSYEQNETKLKNFGQEL 1288

Query: 384  SVSKHTAREL 393
            +  +H+  +L
Sbjct: 1289 AQVQHSIGQL 1298



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 63/330 (19%), Positives = 129/330 (39%), Gaps = 47/330 (14%)

Query: 53  QAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER 112
           Q  GS +S+  +I    + +L +EG +E      D       + +E E +   L+SE ER
Sbjct: 18  QVGGSLASLTGQISNFTKDML-MEGTEEVEAELPD------SRTKEIEAIHAILRSENER 70

Query: 113 LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
           L+K   +LE+  EA         Q+       RN  ++   E+  L+ +   L+    +L
Sbjct: 71  LKKLCTDLEEKHEASE------IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKL 124

Query: 173 DKTEQSLASELEKLKSLTLS----------------------FVSERKYLNEKEKENEKL 210
               QS+ S      +   S                       +S ++ +N    E  +L
Sbjct: 125 QSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL 184

Query: 211 IKEL--TQKLEQNKKMNRDYTRNASNLERNDL-RIEDGISSTLPSKESRRKGGLDYLKQV 267
             E+   + + Q  K      +   N +++++ ++++ I     ++          +  +
Sbjct: 185 ESEVGHWRHIAQTSK-----AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVL 239

Query: 268 ENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFES--LEEELKKMKSKNNDLQDN 325
           +N  + K      R++E+  + D  + IE+L+  ++   S  +E +L K+      +Q  
Sbjct: 240 QNAHQQKLTEISRRHREE--LSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVL 297

Query: 326 YLSEQNKNKLLASQLEEIKLQIKKQKELEN 355
            + +    K +    ++IK   KK    EN
Sbjct: 298 QIEKVESTKKMEQLEDKIKDINKKLSSAEN 327


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 96/438 (21%), Positives = 184/438 (42%), Gaps = 59/438 (13%)

Query: 23   LSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAE-GSNSSMLAEIEVLRQRVLRIEGKD 79
            L+R++  LE AT+ ++  E E   L L+++ ++    +  ++  ++E L +   +++ ++
Sbjct: 647  LARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAEN 706

Query: 80   EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCL 139
             E++R  +  R    KL + E   ++L+ E E L+K +  L+ L +     K++  +L  
Sbjct: 707  LELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK-----KSERLELSY 761

Query: 140  SLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKY 199
                  NL  ++   LE    K + LES    L+   Q+L  +LE L+            
Sbjct: 762  QSVSAENL--RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ------- 812

Query: 200  LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS-TLPSKESR-- 256
            L   EK+ + L +E+ Q  +  K + ++  R    +E  D  ++D  +  +   KESR  
Sbjct: 813  LEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872

Query: 257  -----------------RKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLK 299
                              K   D  KQV    R  +   ++   E  K + L+ E++KL 
Sbjct: 873  DKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLS 932

Query: 300  TQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK-------------LLASQLEEIKLQ 346
             +++      E L +     +D +   L  +N++              LL +Q+EE K  
Sbjct: 933  QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEE-KAS 991

Query: 347  IKKQKELENGEVEGEDAFL---SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE--- 400
            + +Q E E   ++ E   L     +G+H +  F+    + + S        P HK     
Sbjct: 992  LNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051

Query: 401  --RLRNREFALNNENYSL 416
              R+++R   L   N +L
Sbjct: 1052 LLRVKDRAIELERNNAAL 1069



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 101/446 (22%), Positives = 181/446 (40%), Gaps = 54/446 (12%)

Query: 19   KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAE-------------- 64
            KL  + R   +LE   + L+K  D L  L  K  + E S  S+ AE              
Sbjct: 722  KLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHK 781

Query: 65   IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK-- 122
             + L   +  +E + + ++R  +  RL   +LE  E   + L+ E+ +L+K    LEK  
Sbjct: 782  TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEA 841

Query: 123  -----LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
                   E      +D T    ++ +E     K  +       K+KELE  +D  D T+Q
Sbjct: 842  KRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELE--KDNRDLTKQ 899

Query: 178  SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
             +      L +L    V E+    +   E +KL +EL +K+  N+++      + S+ + 
Sbjct: 900  -VTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQEL-EKVGLNRELLLQEDDSGSDTKY 957

Query: 238  NDL--RIEDGISSTLPSKESR---------RKGGLDYLKQVENETRNKSENEKNRNQEDN 286
              L  R E  + +TL  KE +          K  L+  +Q+E+E +   +  +   Q   
Sbjct: 958  KILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN--RQLESELQMLKKECETLRQNQG 1015

Query: 287  KVKDLNQEIEKL--KTQIKH---------FESLEEELKKMKSKNNDLQDNYLSEQNKNKL 335
            + + L    +    KT   H          +    EL ++K +  +L+ N  + Q + +L
Sbjct: 1016 EGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQL 1075

Query: 336  LASQLEEIKLQ-IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELS 394
            L  QL+ ++ Q +    ++    ++ + AFL       +T+      E S     +  L+
Sbjct: 1076 LKEQLQHLETQNVTFSSQILT--LQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133

Query: 395  PQHKRERLRNREFALNNENYSLSNRQ 420
             Q+    L+N   A   EN SL  +Q
Sbjct: 1134 AQY--TLLQNHHTAKETENESLQRQQ 1157



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 89/453 (19%), Positives = 177/453 (39%), Gaps = 30/453 (6%)

Query: 29  ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDL 88
           EL +    L++   EL D  ++++        ++ E++ ++Q  +++       +   D 
Sbjct: 255 ELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDE 314

Query: 89  CRLMKEKLEEEENLTRELKSEIERL------QKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
              ++EK    E L  EL    E+L      + RM EL +       +K    +   +  
Sbjct: 315 LDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAAR 374

Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
              +   ++  E   L+ K+ +LE   D   K  + L  E   L+      +++++ +NE
Sbjct: 375 ARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE------IAQKQSMNE 428

Query: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED--GISSTLPSKESRRKGG 260
                 +L     ++L +N  ++ D +R +   E N+        +     S +S  +G 
Sbjct: 429 SAHLGWEL-----EQLSKNADLS-DASRKSFVFELNECASSRILKLEKENQSLQSTIQGL 482

Query: 261 LDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSK-N 319
            D    +E       E EK  +Q   K++ L  ++E+ K   +  E+L EEL + K +  
Sbjct: 483 RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQ 542

Query: 320 NDLQDNYLSEQNKNKLLASQLEEIK--LQIKKQKELENGEVEGEDAFLSSKGRHER-TKF 376
           +D++     +  + K L  + + +   +   +++   + E   +D    +K  H+  T+ 
Sbjct: 543 SDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEA 602

Query: 377 RGHGSEASVSKHTARELSPQHKR-----ERLRNREFALNNENYSLSNRQVSSPSFTNRRA 431
            G  S+    K        Q K      E+L      L  EN  L+ R+V+S      + 
Sbjct: 603 NGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLA-RKVTSLETATEKV 661

Query: 432 AKASHMGVSTDSGTQETKKTEDRFVPGSSQSEG 464
               H         +  +K+ D     S Q EG
Sbjct: 662 EALEHESQGLQLENRTLRKSLDTLQNVSLQLEG 694



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 100/478 (20%), Positives = 207/478 (43%), Gaps = 41/478 (8%)

Query: 16  LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQ-----DKVIQAEGSNSSMLAEIEVLRQ 70
           L  +L +   R D++ E  K   + + +L DL+     DK    E    +M+ EI   + 
Sbjct: 366 LEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQS 425

Query: 71  --RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-----ELKSEIERLQKRMAELEKL 123
                 +  + E++ +  DL    ++    E N        +L+ E + LQ  +  L   
Sbjct: 426 MNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDA 485

Query: 124 EEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL 183
                 S   C +L    ++     +K+ ++LE  +   ++LE+  + L + ++ L S++
Sbjct: 486 SLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDM 545

Query: 184 EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER---NDL 240
           E LK+       + + + + E+E + L + +    E+++  +    ++     +     +
Sbjct: 546 ETLKA------DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTV 599

Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
              +G  S L  ++ +    L+  K+ + E   K E E  R QE+N    L +++  L+T
Sbjct: 600 TEANGKLSQLEFEKRQLHRDLEQAKE-KGERAEKLERELQRLQEEN--GRLARKVTSLET 656

Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE- 359
             +  E+LE E + ++ +N  L+ +  + QN    ++ QLE ++ +  KQ + EN E+  
Sbjct: 657 ATEKVEALEHESQGLQLENRTLRKSLDTLQN----VSLQLEGLE-RDNKQLDAENLELRR 711

Query: 360 --GEDAFLSSK-GRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSL 416
                 F S+K  + ER   +    +  + K+     +   K ERL     +++ EN  L
Sbjct: 712 LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRL 771

Query: 417 SNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEG----KKSREQ 470
              Q S  S +++     S +G   ++  Q  ++  +     ++Q EG    +K+ EQ
Sbjct: 772 ---QQSLESSSHKTQTLESELG-ELEAERQALRRDLEALRLANAQLEGAEKDRKALEQ 825



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 116/594 (19%), Positives = 223/594 (37%), Gaps = 70/594 (11%)

Query: 41   EDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE 100
            E E   LQ +  Q   +  ++L + E L     R   + E + R     + +   LE E 
Sbjct: 1147 ETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEH 1206

Query: 101  NLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV 160
               +EL      + KR AELE+ E+  +  +        +L +E+        E + LR 
Sbjct: 1207 ---KELGERHGDMLKRKAELEEREKVLTTERE-------ALQQEQRTNALAMGENQRLRG 1256

Query: 161  KVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQ 220
            ++       DR++     L  E E+L + T    +    LN  + E  +      +  EQ
Sbjct: 1257 EL-------DRVNFLHHQLKGEYEELHAHTKELKTS---LNNAQLELNRWQARFDELKEQ 1306

Query: 221  NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN 280
            ++ M+   T+  ++ E     +   +   L  +       +  L Q     +N+   E+N
Sbjct: 1307 HQTMDISLTKLDNHCE-----LLSRLKGNLEEENHHLLSQIQLLSQ-----QNQMLLEQN 1356

Query: 281  RNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK---KMKSKNNDLQDNYLSEQNKNKLLA 337
               ++   ++  Q I+KL    +H E LEE++    K        +++++  +   KL+ 
Sbjct: 1357 MENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIK 1416

Query: 338  SQLEEIKLQIKKQKELENGEVEGEDAF-------LSSKGRHERTKFRGHGSEASVSKHTA 390
             + E  + ++K   +    ++E  D         L S+  +  T   G         H  
Sbjct: 1417 PKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNG 1476

Query: 391  R------ELSPQ----HKRERLR---NREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
                   +L P+    H+    R   + + A+ +    L +R  S+ + T    A ++  
Sbjct: 1477 SVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATT---TAPSNST 1533

Query: 438  GVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTE 497
             ++   G  +   ++D     S + E    R+  S      P++ E S   + TS   + 
Sbjct: 1534 PIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVS-----RPSSLESS---RNTSSNSSP 1585

Query: 498  SGLKGKVEKT-TRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAA 556
              LKG  E+   R+ S ++   +PS  L    + + T      G+  + L     + Q  
Sbjct: 1586 LNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEG 1645

Query: 557  NSGCSKA---IGALASSRRSSSE--GLSKGKKAANGLEADNSCPNSKAPVLSKY 605
                  A   +G    S   SSE   L +  + +N     +  P+ +  +LS Y
Sbjct: 1646 AQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDY 1699


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 86/415 (20%), Positives = 178/415 (42%), Gaps = 39/415 (9%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
           K+    + L   LQ      ++ E     L + E+ L  LQD   Q +G     + ++E 
Sbjct: 358 KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLET 417

Query: 68  LRQRVLRIEGKDE---------EIKRAEDLCRLMKEK--LEEEE----NLTRELKSEIER 112
           L+Q    +   +          E +R +   +L+ E+   EEE+    +L  +L+S I  
Sbjct: 418 LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477

Query: 113 LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
           L +   ELE+  +A                +  +LT ++++    ++ + +EL   + + 
Sbjct: 478 LSQAKEELEQASQAHGARLT---------AQVASLTSELTTLNATIQQQDQELAGLKQQA 528

Query: 173 DKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA 232
            + +  LA  L++ +  +     + + L+   K+ E+ +KE+ +K E  ++ +      A
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588

Query: 233 SNLERNDLRIEDGISSTLPSKESRRKGGLDYLK---QVENETRNKSENEKNRNQEDNKVK 289
           +      LR  D     L + E  +   L+ L+   QV NE R+ ++    + Q +    
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK--A 646

Query: 290 DLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNK---NKLLASQLEEIKLQ 346
           +L++++E+L+  +   E+  +E  + +++  +L+    SEQ K    + +A + ++++ Q
Sbjct: 647 ELSRKVEELQACV---ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703

Query: 347 IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRER 401
           ++  KE     ++     L  + R             S  K   R L  QHKRER
Sbjct: 704 LQALKE----SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 127/588 (21%), Positives = 232/588 (39%), Gaps = 91/588 (15%)

Query: 15   HLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSNS---SMLAEIEVLRQ 70
            H +  L S  R L       ++  KAEDE      +  Q AE  NS   S+  E+ +L +
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNR 1239

Query: 71   RVLRIEGKDEEIKR-----------AEDLCRLMK---------------------EKLEE 98
            +VL  EG+ +E+KR            E+  RL++                     + L E
Sbjct: 1240 QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299

Query: 99   E--------ENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
            E        ENL +EL S+ ER ++   EL+  +E F + +    Q   +L  E   T+ 
Sbjct: 1300 EAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE----QALSTLQLEHTSTQA 1355

Query: 151  ISSELEMLRVKVKELESSE--------DRLDKTEQS---LASELEKLKSLTLSFVSERKY 199
            + SEL   +   ++L++ +        + L++++Q+   L +EL + +      +  R+ 
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415

Query: 200  LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA---------SNLERNDLRIE--DGISS 248
            + E+E+  ++L  E     EQ   + + +   A         +NL R  L +E       
Sbjct: 1416 VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREK 1475

Query: 249  TLPSKESRRKGGLDYLKQVENETRNKSENEK--NRNQEDNKVKDL------NQEIEKLKT 300
             +    + R      L +V+ E ++ +   +      E  KVK L       +E +KL  
Sbjct: 1476 YVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1535

Query: 301  QIKHFESLE-EELKKMKSKNNDLQD-NYLSEQNKNKLLASQLEEIKLQIKKQK-ELENGE 357
            Q++  E  + E+ K+++  +  L D +  S+  + KL A Q +  + Q + Q+ + +  E
Sbjct: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE 1595

Query: 358  VEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLS 417
            ++ + +       H + +      E + + + A++   Q  +E+LR+ E  L  EN  L 
Sbjct: 1596 LQAQLSQKEQAAEHYKLQM-----EKAKTHYDAKKQQNQELQEQLRSLE-QLQKENKELR 1649

Query: 418  NRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSE--GKKSREQPSVLS 475
                       +   K      +    T + +  E +      Q    GK      ++ S
Sbjct: 1650 AEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKS 1709

Query: 476  RYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDP 523
            R P A  +   +         E        K  RT  D T  SVP +P
Sbjct: 1710 REPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGT--SVPGEP 1755



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 82/366 (22%), Positives = 144/366 (39%), Gaps = 57/366 (15%)

Query: 66   EVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKR--------- 116
            E L   +   EGKD+E+ +   L     ++LEE     ++LK ++ + +K          
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109

Query: 117  ----------------MAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV 160
                             AE+ KLE+   + +     L  SL  ER    +  S LE L+ 
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ- 1168

Query: 161  KVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQ 220
               +LE     L  ++ +LAS   +L     +F ++ +  ++ E E +  +    Q+ E+
Sbjct: 1169 --GQLEEKAQELGHSQSALASAQREL----AAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222

Query: 221  NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN 280
               +        S L R  L  E        SKE +R      L   E+E   K E E+ 
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEG------ESKELKR------LVMAESEKSQKLE-ERL 1269

Query: 281  RNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQL 340
            R  +     +  +  E+     +  +SL EE +K +  + +L+    S+       A + 
Sbjct: 1270 RLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ-------AERA 1322

Query: 341  EEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE 400
            EE+  ++K  +E      + E A   S  + E T  +   SE   +KH  ++L  +    
Sbjct: 1323 EELGQELKAWQE---KFFQKEQAL--STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377

Query: 401  RLRNRE 406
              R+RE
Sbjct: 1378 EKRHRE 1383



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 102/483 (21%), Positives = 185/483 (38%), Gaps = 75/483 (15%)

Query: 22   SLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEE 81
            +L+R L +++E     QK  D+L  LQ+K+     + S  +A +E L    +R  G+ +E
Sbjct: 880  NLARALQQVQEKEVRAQKLADDLSTLQEKM----AATSKEVARLETL----VRKAGEQQE 931

Query: 82   ------IKRAEDLCRLMKEKLEEEEN----LTRELKSEIERLQKRMA-ELEKLEEAFSRS 130
                  +K          E LEE++      T+     +ER  ++M  ELE+L  A   S
Sbjct: 932  TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991

Query: 131  -------KNDCTQLCLSLNEERN-------LTKKISSELEM------------------- 157
                   +    +    L +ER        L K   +ELEM                   
Sbjct: 992  QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051

Query: 158  LRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEK---LIKEL 214
            L   + E E  +  L K     A+++++L+ L  +    ++ L +KEKE+        E 
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111

Query: 215  TQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK 274
              + E             S LE+   + ++   S   S E+ R    +    +E      
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171

Query: 275  SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK 334
             E  +      + +    +E+   +T+++     E+E K   ++           + KN 
Sbjct: 1172 EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ------EAERKNS 1225

Query: 335  LLASQLEEIKLQIKK--QKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARE 392
            L++S  EE+ +  ++  +KE E+ E++      S K +    + R   +E + +   A E
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285

Query: 393  LSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTE 452
             S   + E    RE A      S + RQ         +A +A  +G       QE K  +
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQE-----LTSQAERAEELG-------QELKAWQ 1333

Query: 453  DRF 455
            ++F
Sbjct: 1334 EKF 1336



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 80/382 (20%), Positives = 158/382 (41%), Gaps = 47/382 (12%)

Query: 39  KAEDELLDLQDKVIQAEGSN------SSMLAEI---EVLRQRVLRIEGKDEEIKRAEDLC 89
           K E   L+LQ     + G+N      +S + +I      + R L+ +  DE   R E   
Sbjct: 176 KREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDE--- 232

Query: 90  RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTK 149
             ++ +L E   L  E  ++I  +Q+R+  L  L E  + S  +  +L    ++  +LT 
Sbjct: 233 --LELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290

Query: 150 KISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEK 205
           ++   L+    + ++L++ + ++D+    L+ E   L      F S  + L    NE  +
Sbjct: 291 RLHETLK----QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTE 346

Query: 206 ENEKLIKELTQKLEQ-NKKMNRDYTRNASNLERNDL------RIEDGISSTLPSKESRRK 258
           E+ K  +E  +K  Q  K+++          E+N++      ++E+ +S    +    + 
Sbjct: 347 EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406

Query: 259 GGLDYLKQVENETRNKSENEKNRNQEDNKVKDL----NQEIEKLKTQIKHFESLEEELKK 314
             L  + Q+E   +  +    N  Q   +V+ L     Q+  KL  +  HF   EEE ++
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF---EEEKQQ 463

Query: 315 MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
           + S   DLQ +            S L + K ++++  +     +  + A L+S+      
Sbjct: 464 LSSLITDLQSS-----------ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512

Query: 375 KFRGHGSEASVSKHTARELSPQ 396
             +    E +  K  A+E   Q
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQ 534



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 126/575 (21%), Positives = 217/575 (37%), Gaps = 101/575 (17%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQKA-EDELLDLQDKVIQAEGSNSSMLAEIE 66
            K T   R  + K Q L  +L  L+E+ K  + + E+E     D + + +   S + AE  
Sbjct: 686  KATEKERVAQEKDQ-LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744

Query: 67   VLRQRVLRIEGKDEEIKRA------EDLCRLMKEKLEEEENLTREL----------KSEI 110
             L ++  R E K+ E +RA        L +L +    E E L REL          +SE 
Sbjct: 745  SLVEQHKR-ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803

Query: 111  ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTK----KISSELEMLRVKVKELE 166
            E+L K +A      E +  S+ +  Q      E+    K    K   EL+  + KV  +E
Sbjct: 804  EQLVKEVAAWR---ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860

Query: 167  SSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEK---------------EKENEKLI 211
            S  +     +Q+  +EL    +  L  V E++   +K                KE  +L 
Sbjct: 861  SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920

Query: 212  KELTQKLEQNKKMNRDYTRNASNL-ERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
              + +  EQ +  +R+  +  +   +R    +E+       S ++  +      +Q+ NE
Sbjct: 921  TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980

Query: 271  --------TRNKSENEKNRNQEDNKVKDLNQE---------IEK-------------LKT 300
                      ++ + ++ R Q++ +V  L QE         +EK             L  
Sbjct: 981  LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040

Query: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE----LENG 356
            Q   F +L+E L    ++           +        +LEE++  +K+ KE     E  
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100

Query: 357  EVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSL 416
               G  A   + GR E T  +     A VSK    E   Q ++E+  + E +L  E  S 
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSK---LEQQCQKQQEQADSLERSLEAERASR 1157

Query: 417  SNRQVSSPSFTNRRAAKASHMGVSTD-------------SGTQETKKTEDRF----VPGS 459
            + R  +  +   +   KA  +G S               +  Q+  K ED +      G 
Sbjct: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR 1217

Query: 460  SQSEGKKS-----REQPSVLSRYPPAAQEHSKAWK 489
             ++E K S      E+ S+L+R     +  SK  K
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 85/455 (18%), Positives = 189/455 (41%), Gaps = 56/455 (12%)

Query: 3    EFTSYKETASSR--HLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
            E  + +  A +R   ++ + QS +R   ELE  T   + A+ ++L+ + +  +     ++
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTAR---ELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1535

Query: 61   MLAEIEVL-RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE 119
             + ++EV  R++  ++E   +++  ++   ++ ++KL+  +    E + E +RLQ +   
Sbjct: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ--- 1592

Query: 120  LEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSL 179
            L +L+   S+ +       L + + +        + + L+ +++ LE    +L K  + L
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648

Query: 180  ASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERND 239
             +E E+L         E +    K KE E+  + LT ++   +       +   +L +  
Sbjct: 1649 RAEAERLG-------HELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701

Query: 240  LRIEDGISSTLPSKESRRKGGLDYLK-QVENETRNKSENEKNRNQEDNKV---KDLNQEI 295
            +   D + S  P  + +    +D L    E  T     ++  R Q D      +  +   
Sbjct: 1702 V-ATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS 1760

Query: 296  EKLKTQIKHFESL------EEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKK 349
            ++L  +++  ESL            ++S  + L D +L    K +    +  +I + I  
Sbjct: 1761 QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQI-INITM 1819

Query: 350  QKELENGEVE-GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
             K+L+  E +    +F S++              A  S+ + R  S      RL + ++ 
Sbjct: 1820 TKKLDVEEPDSANSSFYSTR-------------SAPASQASLRATSSTQSLARLGSPDYG 1866

Query: 409  LNNENYSLSNRQVSSPSF--TNRRAAKASHMGVST 441
                    ++  +S P +  T R +A+ S  GVS+
Sbjct: 1867 --------NSALLSLPGYRPTTRSSARRSQAGVSS 1893


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 83/395 (21%), Positives = 184/395 (46%), Gaps = 64/395 (16%)

Query: 8    KETASSRHLRFKLQSLSRRLDELEEATKNLQKA----EDELLDLQDKV--IQAEGSNSSM 61
            K ++ +  L+F+L+  ++ L  L+   ++L++     + E  ++Q K+  ++  G +   
Sbjct: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126

Query: 62   LAEIE----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERL---- 113
            + E+E    ++++ V +++ ++E++K+A  +  L  EK+   E    +LK+E+E+L    
Sbjct: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGI--LTSEKMANIEQENEKLKAELEKLKAHL 2184

Query: 114  ---------------QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEML 158
                           +K +AE E+L +   +  +   +L ++ N    L +K++ +LE  
Sbjct: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET 2244

Query: 159  RVKVKELESSEDRLDKTEQSLASEL-------EKLKSLTLSFVSERKYLNEKEKENEKLI 211
              +++  ES   +L+  +      +        KLK L      +    N+   + ++L+
Sbjct: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK----NQSITDLKQLV 2300

Query: 212  KELTQKLEQNKKMNRDYTRNASNLER--NDLRIEDGISSTLP----SKESRRKGGLDYLK 265
            KE T++ ++  K N D  +    L+        E G+   L     +     K   + + 
Sbjct: 2301 KEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIH 2360

Query: 266  QVE-NETRNKSENE-KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMK------- 316
            Q+E N+ ++ +E+   + +Q   K+KDL  +++    + +H   L+EE+KK+K       
Sbjct: 2361 QIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH---LKEEIKKLKKELENFD 2417

Query: 317  ----SKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
                 +  DL+ NY  E  KN LL  +++++  Q+
Sbjct: 2418 PSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 94/428 (21%), Positives = 187/428 (43%), Gaps = 55/428 (12%)

Query: 29  ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLA---EIEVLRQRVLRIEGK-----DE 80
           EL EA K L+  E  +  L+D V++ +   + +     EIE+L + + ++E K     DE
Sbjct: 440 ELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDE 499

Query: 81  ----------EIKRAEDLCRLMKEKLEEEENLTRE---LKSEIERLQKRMAELEKLEEAF 127
                     E K   DL      K  +++    E   L  EIE L++   +L+K     
Sbjct: 500 NEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM 559

Query: 128 SRSKNDCTQLCLSLNEERNLTKKISS-------ELEMLRVK-VKELESSEDRLDKTEQSL 179
           ++ +   +       E+ NLT+ IS        +L++L +K + E +S  + L +     
Sbjct: 560 AQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK 619

Query: 180 ASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERND 239
             +LE+ +++   F ++ K L E+ K+ E+ +KE+ Q +++ +K + D     ++L    
Sbjct: 620 ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQK-DPDVKGGETSLIIPS 678

Query: 240 L-RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKL 298
           L R+ + I S   + E      L    QV+  T    E  +   +   +  + +Q++ K 
Sbjct: 679 LERLVNAIES--KNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736

Query: 299 KTQIKHFESLEEELKKMKSKN-----NDLQDNYLSE-----QNKNKLLASQLEEIKLQIK 348
             +I H E     L++ +  N      DL D           ++N+ L   L+E++ + K
Sbjct: 737 NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK 796

Query: 349 KQKELEN---------GEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR 399
           K K LE+           +  + + L  +   E+  ++   +E+   K   R+L  Q ++
Sbjct: 797 KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWK---TESKTIKEEKRKLEDQVQQ 853

Query: 400 ERLRNREF 407
           + ++ +E+
Sbjct: 854 DAIKVKEY 861



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 110/499 (22%), Positives = 214/499 (42%), Gaps = 84/499 (16%)

Query: 13  SRHLRFKLQSLSRRLD----ELEEATKNLQKAE--DELLDLQDKVIQAEGSNSSMLAE-- 64
           +R LR ++  L ++L+    ELE+  K L+K +  +E L L+++  +AE  NS +  E  
Sbjct: 110 TRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE--EAENENSKLRRENK 167

Query: 65  -------------------IEVLRQRVLRIEGKDEEI-----KRAEDLCRLM-------- 92
                              I+  ++ +L   G+D +      K+  +L + +        
Sbjct: 168 RLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE 227

Query: 93  -KEKLE-EEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL-------CLSLNE 143
             EK+E + + + + L+  ++ ++K   E  +++    ++ N   QL        L + E
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQE 287

Query: 144 ERNLTKKISSELEMLRV----KVKE----LESSEDRLDKTEQSLASELEKLKSLTL-SFV 194
             +L K  + E + + V    KV+E    L S +D + + +Q L +  EKLK+  L +  
Sbjct: 288 LTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADK 347

Query: 195 SERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKE 254
           S    L +  +E +  IK LT+++EQ  K     T    +L +N+L+   G S+      
Sbjct: 348 SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDL-KNELQRNKGASTLSQQTH 406

Query: 255 SRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK 314
            + +  LD LK+   E    +E  +   +E  K K+L + +++LK        LE+ + +
Sbjct: 407 MKIQSTLDILKEKTKEAERTAELAEADARE--KDKELVEALKRLKDYESGVYGLEDAVVE 464

Query: 315 MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
           +K+  N ++        + ++L  ++   KL++K    L+  E   E   L  K   + T
Sbjct: 465 IKNCKNQIK----IRDREIEILTKEIN--KLELKISDFLDENEALRERVGLEPKTMIDLT 518

Query: 375 KFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
           +FR        SKH         K+++ R     L  E  SL   ++       + A + 
Sbjct: 519 EFRN-------SKHL--------KQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563

Query: 435 SHMGVSTDSGTQETKKTED 453
                ++   T++   TE+
Sbjct: 564 GKRSATSGLTTEDLNLTEN 582



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 97/439 (22%), Positives = 189/439 (43%), Gaps = 49/439 (11%)

Query: 3    EFTSYKETASSRHLRFKLQSLSRRLDELEEATK-NLQKAEDELLDLQDKVIQAEGSNSSM 61
            E T  ++  S   L  KL+ +S+ L+   E T+  +++ E+  L LQ+     E     +
Sbjct: 1627 EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQEN---HEDEVKKV 1683

Query: 62   LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
             AE+E L+  +L    K+ +  ++E    L  +K       T  +++ +ERL+ ++A  E
Sbjct: 1684 KAEVEDLKY-LLDQSQKESQCLKSE----LQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738

Query: 122  KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEM---------LRVKVKELESSEDRL 172
            K ++A SR+  +      +  EER ++     E  +          R    ++E   + L
Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798

Query: 173  DKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA 232
             K +++L +   +  SLT +       L +K+K   K+++E  +  ++N ++ R   R  
Sbjct: 1799 LKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLT 1858

Query: 233  SNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE-------NEKNRNQE- 284
            S L+   L   D   S +  +E +RK     +K++EN+   K E        EKN  +E 
Sbjct: 1859 SGLQGKPL--TDNKQSLI--EELQRK-----VKKLENQLEGKVEEVDLKPMKEKNAKEEL 1909

Query: 285  --DNKVKDLNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
                + K    +IE ++ ++K  E    +L ++L  +K          L+ Q K K    
Sbjct: 1910 IRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGM 1969

Query: 339  QLEEIK--LQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQ 396
             ++++     ++ +KELE  +    D        ++    R H +    S      L  +
Sbjct: 1970 TVDQVLGIRALESEKELEELKKRNLDL------ENDILYMRAHQALPRDSVVEDLHLQNR 2023

Query: 397  HKRERLRNREFALNNENYS 415
            + +E+L   E   + + YS
Sbjct: 2024 YLQEKLHALEKQFSKDTYS 2042



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 103/468 (22%), Positives = 192/468 (41%), Gaps = 66/468 (14%)

Query: 3    EFTSYKETASSRHL---RFKLQSLSRRLDELEEATKNLQKAEDELLDL---QDKVIQAEG 56
            EF S +     R L   R  +     +L EL E  K L++   E+L       K    +G
Sbjct: 610  EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKG 669

Query: 57   SNSSMLAEIEVLRQRVLRIEGKDEE----------------IKRAEDLCRLMKEKLEEEE 100
              +S++  I  L + V  IE K+ E                  R E+L + ++E  +E  
Sbjct: 670  GETSLI--IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 727

Query: 101  NLTRELKS---EIERLQKRMAELEKLE------EAFSRSKNDCTQLCLSLNEERNLTKKI 151
            N +++L     +I+ L+K  + L + E      +               +N +      +
Sbjct: 728  NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 787

Query: 152  SSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKE--KENEK 209
              ELE    K K+L++ ED L+   +  A  +   +SL       ++YL+EKE  K   K
Sbjct: 788  LQELEN---KEKKLKNLEDSLEDYNRKFA-VIRHQQSLLY-----KEYLSEKETWKTESK 838

Query: 210  LIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGL-------- 261
             IKE  +KLE   + +    +  +NL  N L+++      + ++ SR+   L        
Sbjct: 839  TIKEEKRKLEDQVQQDAIKVKEYNNL-LNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897

Query: 262  -DYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
              Y   VE E + + ENEK +N+  +   ++ ++I  L+   +        L+K+   + 
Sbjct: 898  RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957

Query: 321  DLQDNYLSEQNKNKLLASQ---LEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFR 377
             L +  L+ +  N+L A     L++  + +++   LE+ E E     +S K + E     
Sbjct: 958  SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECEN----ISLKEQVESI--- 1010

Query: 378  GHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
                E  ++K     +    ++E     E +++    S++N  + S S
Sbjct: 1011 --NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS 1056



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 101/467 (21%), Positives = 189/467 (40%), Gaps = 84/467 (17%)

Query: 16  LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
           ++ K Q +   L+E+E+A +   K E++L   + KV++ E        E+E+ +Q     
Sbjct: 59  MKMKAQEVELALEEVEKAGEEQAKFENQL---KTKVMKLEN-------ELEMAQQSA--- 105

Query: 76  EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
            G+D    R E +C+L K+                  L+++  ELE +E+   + K    
Sbjct: 106 GGRDTRFLRNE-ICQLEKQ------------------LEQKDRELEDMEKELEKEKKVNE 146

Query: 136 QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
           QL L   E  N   K+  E + L+ K ++L   +D +D  +Q + S+ E L S       
Sbjct: 147 QLALRNEEAENENSKLRRENKRLKKKNEQL--CQDIIDYQKQ-IDSQKETLLSRRGEDSD 203

Query: 196 ERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKES 255
            R  L++K  E  + + E+    E N+K+         NLE +                 
Sbjct: 204 YRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES----------------- 246

Query: 256 RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKM 315
                   ++++E  T   +  +   +Q DN        I++LK +  H++   +EL  +
Sbjct: 247 --------VQEMEKMTDEYNRMKAIVHQTDNV-------IDQLKKENDHYQLQVQELTDL 291

Query: 316 KSKNNDLQDNYLSEQNK-----NKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
               N+  D  +   N        +L+S+ +EI   I+ Q+ L N   + ++A L +   
Sbjct: 292 LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEI---IEYQQMLHNLREKLKNAQLDADKS 348

Query: 371 HERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRR 430
           +     +G     S  K    ++  Q+ +E  +N     + +N    N+  S+ S     
Sbjct: 349 NVMALQQGIQERDSQIKMLTEQVE-QYTKEMEKNTCIIEDLKNELQRNKGASTLS----- 402

Query: 431 AAKASHMGV-STDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSR 476
             + +HM + ST    +E  K  +R    +     +K +E    L R
Sbjct: 403 --QQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKR 447



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 80/402 (19%), Positives = 180/402 (44%), Gaps = 45/402 (11%)

Query: 16   LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
            L+ +++S+++ L+  +E    +++A ++   L ++    +   S   ++I  + +++  +
Sbjct: 1003 LKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITML 1062

Query: 76   EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
            E K+   ++  + C+ M E           L++ ++++++R  ELE      ++   D  
Sbjct: 1063 EMKELNERQRAEHCQKMYE----------HLRTSLKQMEERNFELETKFAELTKINLDAQ 1112

Query: 136  QLCLSLNEER--NLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
            ++   L +E   +++K +S   +  R ++ ELE       K E  L  E+ KL+ ++   
Sbjct: 1113 KVEQMLRDELADSVSKAVS---DADRQRILELE-------KNEMELKVEVSKLREISDIA 1162

Query: 194  VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERN-DLRIEDGIS-STLP 251
              + + LN +++  +K ++ L  +L   +  + + +  A   + N  L++ +  +   L 
Sbjct: 1163 RRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLE 1222

Query: 252  SKESRRKGGLDYLKQVENETRNKSEN-EKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEE 310
            S  S+ +    Y  ++E +   K +     R +  N+ K L Q I+ L+ Q      L +
Sbjct: 1223 SITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQ 1282

Query: 311  ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
            + K  K+         + +   +KL    ++E+K   ++ + +EN  +E E   L  KG 
Sbjct: 1283 QEKFSKT---------MIQLQNDKL--KIMQEMKNSQQEHRNMENKTLEME---LKLKGL 1328

Query: 371  HERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNE 412
             E        S    +K   + ++   K E LR +E  LN E
Sbjct: 1329 EELI------STLKDTKGAQKVINWHMKIEELRLQELKLNRE 1364



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 91/396 (22%), Positives = 170/396 (42%), Gaps = 52/396 (13%)

Query: 17   RFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIE 76
            R   +SL  +L E E A   L+ AE  +L  +DKVI          AE E L   + R E
Sbjct: 1471 RATCKSLEEKLKEKESA---LRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGRKE 1526

Query: 77   GKDEE---IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK----------- 122
             + +    +K A      M+ +L ++E + ++ +  +E+ ++   E+ K           
Sbjct: 1527 MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHH 1586

Query: 123  -LEEAFSRSKNDCTQLCLSLNEERNL---TKKISSELEMLRVKVKELESSEDRLDKTEQS 178
             LE     S N   Q    L ++      T K    L  +   V E + S   L    + 
Sbjct: 1587 RLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646

Query: 179  LASELEKLKSLTLSFVSERKYLNEKEKEN-EKLIKELTQKLEQNKKMNRDYTRNASNLER 237
            ++ +LE+ + +T   V E + +  + +EN E  +K++  ++E  K +  D ++  S   +
Sbjct: 1647 VSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYL-LDQSQKESQCLK 1705

Query: 238  NDLRIEDGISSTLPS----------------KESRRKGGLDYLKQVENETRNKSENE--- 278
            ++L+ +   +S  P+                KE ++K     L ++  E    +E     
Sbjct: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765

Query: 279  --KNRNQEDNKVKDLNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNK 332
                +    N  + +++   +LKTQ++        L+E LK  K++ N L DN L++ N 
Sbjct: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDN-LNDLN- 1823

Query: 333  NKLLASQLEEIK-LQIKKQKELENGEVEGEDAFLSS 367
            N+L   Q    K L+ K++ + EN E++ +   L+S
Sbjct: 1824 NELQKKQKAYNKILREKEEIDQENDELKRQIKRLTS 1859



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 77/399 (19%), Positives = 163/399 (40%), Gaps = 82/399 (20%)

Query: 27  LDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAE 86
           +D+L++   + Q    EL DL     + E  +  M+A    + +  L +  KD+EI   +
Sbjct: 271 IDQLKKENDHYQLQVQELTDLLKS--KNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ 328

Query: 87  DLCRLMKEKL------------------------------EEEENLTRELKSEIERLQKR 116
            +   ++EKL                              E+ E  T+E       ++K 
Sbjct: 329 QMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKE-------MEKN 381

Query: 117 MAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD--- 173
              +E L+    R+K   T     L+++ ++  KI S L++L+ K KE E + +  +   
Sbjct: 382 TCIIEDLKNELQRNKGAST-----LSQQTHM--KIQSTLDILKEKTKEAERTAELAEADA 434

Query: 174 -KTEQSLASELEKLK----------SLTLSFVSERKYLNEKEKENEKLIKELTQK----- 217
            + ++ L   L++LK             +   + +  +  +++E E L KE+ +      
Sbjct: 435 REKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS 494

Query: 218 --LEQNKKMNR----------DYT--RNASNLERNDLRIEDGI-SSTLPSKESRRKGGLD 262
             L++N+ +            D T  RN+ +L++   R E+ I    + S E  R     
Sbjct: 495 DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKK 554

Query: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQ--EIEKLKTQIKHFESLEEELKKMKSKNN 320
            ++Q+  E   +S       ++ N  ++++Q   I + K  +   +++ E   K +  + 
Sbjct: 555 KIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSR 614

Query: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
           +L +     +    ++A    ++K  +++ K+LE G  E
Sbjct: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKE 653



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 80/346 (23%), Positives = 146/346 (42%), Gaps = 69/346 (19%)

Query: 29   ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLR-IEGKDEEIKRAED 87
            +LE       + ++E+L+   K  +A GS       +    +  LR I+     I     
Sbjct: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472

Query: 88   LCRLMKEKLEEEENLTRELKSE-------IERLQKRM---AELEKLEEAFSRSKND---- 133
             C+ ++EKL+E+E+  R  +         I  L+ R+   AE EKL     R + +    
Sbjct: 1473 TCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSH 1532

Query: 134  ---------CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
                        +   LN++  + KK    LE  R + +E+      + K E+ L     
Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI------VKKHEEDLHILHH 1586

Query: 185  KLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
            +L+      +     LN+ ++    L+K+    +  NK   R      + +E+     +D
Sbjct: 1587 RLE------LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR-----LAEMEQTVAEQDD 1635

Query: 245  GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKH 304
             +SS L             LK+V  +       E+ R   + KVK    E E +K Q++ 
Sbjct: 1636 SLSSLLVK-----------LKKVSQDL------ERQREITELKVK----EFENIKLQLQ- 1673

Query: 305  FESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
             E+ E+E+KK+K++  DL+  YL +Q++ +   SQ  + +LQ +K+
Sbjct: 1674 -ENHEDEVKKVKAEVEDLK--YLLDQSQKE---SQCLKSELQAQKE 1713


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 93/504 (18%), Positives = 219/504 (43%), Gaps = 50/504 (9%)

Query: 7   YKETASSRHLRFKLQSLSRRLD-----------ELEEATKNLQKAEDELLDLQDKVIQAE 55
           Y+ T ++  L+ K   L  +L             ++E  + L++A+  L  +Q   +Q E
Sbjct: 214 YRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273

Query: 56  GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQK 115
                M  + E LR++  +I  ++E++ R E+  R  + K+ E+E        ++ R +K
Sbjct: 274 -----MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE-------EKMWRQEK 321

Query: 116 RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT 175
           R+ E EK      +   +  +L     + +   +K+  + E +R + +++   E+RL + 
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381

Query: 176 EQSLASELEKLKSLTLSFVSERKYLNEKE---KENEKLIKELTQKLEQNKKMNRD--YTR 230
           E+ +  + +K++        + + L EKE   +E EK+ +++ +K+ + KKM      TR
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV-EKMREEKKMQEQEKKTR 440

Query: 231 NASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
           +     + + RI +        +E + +   + +++ E + + + EN   + +++ + + 
Sbjct: 441 DQEEKMQEEERIRE--------REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492

Query: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQN--KNKLLASQLEEIKLQIK 348
           L ++ EKL  Q K  +  EE++ + + K  D ++ +  E+   + + +  Q +++  Q +
Sbjct: 493 LPEQKEKLWEQEK-MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551

Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
           K ++ E    + E+         E+  +          +   RE   + + E +R +E  
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 409 LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDS-GTQETKKTEDRFVPGSSQS--EGK 465
           +  +   +  ++        +   +   M    +    QE K  E + +P   +   E +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671

Query: 466 KSREQPSVLSRYPPAAQEHSKAWK 489
           K +EQ  +        ++  K W+
Sbjct: 672 KMQEQEKM-------QEQEEKIWE 688



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 99/537 (18%), Positives = 211/537 (39%), Gaps = 55/537 (10%)

Query: 8   KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
           ++    R    K+    +RL E E+  +  +K   E  +L+++  Q +     M  + E 
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363

Query: 68  LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
           +R++  ++  ++E +   E   R  ++K+ ++E    E    +   ++RM E EK+ E  
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423

Query: 128 SRSK------------NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT 175
            + +             D  +        R   KK+  E E +R + ++++  E+ + + 
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 176 E------QSLASELEKLKSLTLSFVSERKYLNEKEK---------------ENEKLIKEL 214
           E      Q L  + EKL         E K   ++EK                 EK+ ++ 
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543

Query: 215 TQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK 274
            Q  EQ +KM     +     ER + + ++    T   +E  R    +  +  E E + +
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR----EEERMREREKKMR 599

Query: 275 SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK 334
            E E  R QE+     + ++ EK++ Q +     EE++++ + K  + ++    ++ K  
Sbjct: 600 EEEEMMREQEEK----MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK-- 653

Query: 335 LLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR-HERTKFRGHGSEASVSKHTAREL 393
                 E+ +L  +K+K  E+ +++ ++     + +  E+ K      E    +    + 
Sbjct: 654 ----MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE---QEKKTWDQ 706

Query: 394 SPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDS-GTQETKKTE 452
               + E +R RE  +  E   +  ++        +   +   M    +    QE K  E
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766

Query: 453 DRFVPGSSQS--EGKKSREQPSVLSRYPPAA-QEHSKAWKGTSKPGTESGLKGKVEK 506
            + +P   +   E +K +EQ  +  +      QE     +     G E  ++G+ EK
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 62/307 (20%), Positives = 140/307 (45%), Gaps = 18/307 (5%)

Query: 16  LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
           +R + + +    + + E  + +Q+ E+++ + ++K+ + E        ++    +++   
Sbjct: 591 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650

Query: 76  EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
           E K  E +R  +     KEKL E E +  + K  ++  ++++ E EK+E+     +    
Sbjct: 651 EEKMWEQQRLPE----QKEKLWEHEKMQEQEK--MQEQEEKIWEQEKMEKKTQEQEKKTW 704

Query: 136 QLCLSLNEE--RNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
                  EE  R   KK+  E EM+R + ++++  E+++ + E+ +  + EK+       
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764

Query: 194 VSERKYLNEKEK--ENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
             +++   +KEK  E+EK+ +E  +  EQ +KM     R+     R       G    + 
Sbjct: 765 WEQQRLPEQKEKLWEHEKM-QEQEKIWEQEEKM-----RDQEEKMRGQEEKMRGQEEKMR 818

Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE 311
            +E +  G  +  K    E +   + EK   QE+   + +  + EK++ Q +     EE+
Sbjct: 819 GQEEKMWGQEE--KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876

Query: 312 LKKMKSK 318
           +++ + K
Sbjct: 877 MREQEEK 883



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 65/300 (21%), Positives = 134/300 (44%), Gaps = 31/300 (10%)

Query: 80  EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRM--AELEKLEEAFS----RSKND 133
           EE+ +  D   L   +L        ELK +   LQ+++  AE EK E   +    + K +
Sbjct: 200 EELTKERDALSL---ELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256

Query: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
             +  L   +   L +++  + E LR + K++   E+++ + E+ L  +  K++      
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316

Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
             + K L E+EKE  +  KEL ++ E  ++  +   +     E+ +             +
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE-----------KMR 365

Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQED---NKVKDLNQEIEKLKTQIKHFESLEE 310
           E   K      +  E E + + + +K R+QE+    + + L ++ E+++ Q K +E +E+
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425

Query: 311 --ELKKM---KSKNNDLQDNYLSEQ---NKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
             E KKM   + K  D ++    E+    + K +  + E ++ Q +K ++ E    E E+
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 58/330 (17%), Positives = 130/330 (39%), Gaps = 34/330 (10%)

Query: 123 LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 182
           L +AF  S   C    L   E ++L  ++           + L +   R  K ++ +   
Sbjct: 143 LSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEEL 202

Query: 183 LEKLKSLTLSFVSERKYLNEKEKENEKL-----------------IKELTQKLEQNKKMN 225
            ++  +L+L          E +K+N +L                 +KEL +KLE+ K + 
Sbjct: 203 TKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL 262

Query: 226 RDYTRNASNLERNDLRIEDGI---SSTLPSKESRRKGGLDYLKQVENETRNKSE----NE 278
                N   L+    R E+ +      +  +E +     + L++ E + R + E     E
Sbjct: 263 PQVQTN--TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQE 320

Query: 279 KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
           K   +++ ++++  +E+ + K   +  E ++E+ +KM  +   +++       + + L  
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380

Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR--------HERTKFRGHGSEASVSKHTA 390
           Q ++++ Q +K ++ E    E ++     + R         +  K R         K T 
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440

Query: 391 RELSPQHKRERLRNREFALNNENYSLSNRQ 420
            +     + ER+R RE  +  E  ++  ++
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQE 470


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 94/406 (23%), Positives = 184/406 (45%), Gaps = 47/406 (11%)

Query: 19   KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
            K+++L+  +  L+E+   L K   E   LQ+   QA G   +    +  L +  LR+E +
Sbjct: 1023 KVKNLTEEMAALDESVARLTK---EKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQ 1079

Query: 79   DEEIKRAEDLCRLMKEKL--EEEENLTRELKSEIERLQKRMAEL----EKLEEAFSRSKN 132
             E+++     C L +EK    + E   R+L+ +++  Q+ +A+     ++LEE   +  +
Sbjct: 1080 VEDLE-----CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134

Query: 133  DCTQLCLSLNEERNLTKKISSELEMLRVKVKELE-------SSEDRLDKTEQSLASEL-- 183
            + +QL L + +E+ L  ++  +++ L+ + +ELE       ++  R++K     A EL  
Sbjct: 1135 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEE 1194

Query: 184  --EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNK----KMNRDYTRNASNLER 237
              E+L+    +   +R+   ++E E  +L +EL +   +++     + R     A+ L  
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254

Query: 238  NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDN------KVKD 290
                ++         K   R    D    VE  TR K+  EK  R  ED       KV++
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314

Query: 291  LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ-LEEIKLQIKK 349
            L +++    TQ    ++   EL ++  +   L    +S+ ++ K LA+Q LEE++ Q+++
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSRLLEEKECL----ISQLSRGKALAAQSLEELRRQLEE 1370

Query: 350  QKELENGEVEGEDAFLSSKGRHERTKFR-GHGSEASVSKHTARELS 394
            + + ++       A      RH+    R  H  EA       R LS
Sbjct: 1371 ESKAKSALAHAVQAL-----RHDCDLLREQHEEEAEAQAELQRLLS 1411



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 84/414 (20%), Positives = 173/414 (41%), Gaps = 35/414 (8%)

Query: 16   LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML-AEIEVLRQR--- 71
            L FK++ L R     EE    L     EL  L+  +  AE     +    + + +++   
Sbjct: 881  LFFKMKPLLRSAQAEEE----LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL 936

Query: 72   VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
             L+++ + + +  AE+ C L+ +   + E   +EL   +E  ++  A+L        + +
Sbjct: 937  ALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRR---KLE 993

Query: 132  NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
            ++CT+L   +++ +    K   E +    KVK L      LD++   L  E + L+    
Sbjct: 994  DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053

Query: 192  SFVSERK-------YLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
              + + +        L + +   E+ +++L   LEQ KK+  D  R    LE +    ++
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113

Query: 245  GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRN----QEDNKVKDLNQEIEKLKT 300
             ++     K+       + LK+ ++E    S   ++      Q   K+K+L    E+L+ 
Sbjct: 1114 SVADAAQDKQQLE----EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169

Query: 301  QIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
            +++   +    ++K +++   +L++     +      A Q E  +   K++ EL     E
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR---KREAELGRLRRE 1226

Query: 360  GEDAFLSSKGRHERTKFRGHGSEASVSKHTAREL-SPQHKRERLRNREFALNNE 412
             E+A L    RHE T       +A  +     ++ S Q  R++L   +  L  E
Sbjct: 1227 LEEAAL----RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRME 1276



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 121/614 (19%), Positives = 232/614 (37%), Gaps = 76/614 (12%)

Query: 17   RFKLQSLSRRLDELEEATKNLQKAEDELLDLQDK----VIQAEGSNSSMLAEIEVLRQRV 72
            + K++ L R+L +       LQ    EL  L ++    + Q     +     +E LR R 
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR-RQ 1367

Query: 73   LRIEGKDEE-----IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
            L  E K +      ++     C L++E+ EEE     EL+  + +    +A+     EA 
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEA- 1426

Query: 128  SRSKNDCTQLCLSLNEERNLTKKISSEL-------EMLRVKVKELESSEDRLDKTEQSLA 180
                 D  Q    L E +   KK++  L       E    K   LE ++ RL    + + 
Sbjct: 1427 -----DAIQRTEELEEAK---KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478

Query: 181  SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
             ELE+  S   +       L++K++  E+ ++E  ++ E+ ++      R +  L     
Sbjct: 1479 LELERATSAAAA-------LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELF 1531

Query: 241  RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
            R+  G    L + E+ ++   +  +++ + T   S + K+  + +   K L  E  +++ 
Sbjct: 1532 RLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQA 1591

Query: 301  QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
             ++  E    EL++ K+    L+ + +  +   KL     E   L+   Q+ +E+ +   
Sbjct: 1592 ALEEAEG-ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA-S 1649

Query: 361  EDAFLSSKGRHERTKFRGHGSEASVS---KHTARELSPQHKRERLR----NREFALNNEN 413
             DA   ++    R K +  G    +     H  R+ +      RL       E A  +E 
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709

Query: 414  YSLSNRQVSSPSFTNRR----AAKASHMGVSTDSGTQETKKTEDRFVPGS-------SQS 462
              L+           RR    AA+   +  + + G +  +  E   +  +       SQ+
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769

Query: 463  EG------KKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTH 516
             G      K   +   +      AAQE  +A +   K  T++ +  +  K  +       
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ------- 1822

Query: 517  GSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGAL-ASSRRSSS 575
                 D     ++   T  +TV   +  +     +  QAA  G  K +  L A  R   +
Sbjct: 1823 -----DTSAHLERMKKTLEQTVRELQARL----EEAEQAALRGGKKQVQKLEAKVRELEA 1873

Query: 576  EGLSKGKKAANGLE 589
            E  ++ KK A  L+
Sbjct: 1874 ELDAEQKKHAEALK 1887


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.123    0.329 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,389,971
Number of Sequences: 37866
Number of extensions: 2005108
Number of successful extensions: 19437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 395
Number of HSP's successfully gapped in prelim test: 1365
Number of HSP's that attempted gapping in prelim test: 8348
Number of HSP's gapped (non-prelim): 5902
length of query: 1076
length of database: 18,247,518
effective HSP length: 113
effective length of query: 963
effective length of database: 13,968,660
effective search space: 13451819580
effective search space used: 13451819580
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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