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Search of human proteins with 216548085
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|216548085 leucine zipper protein 1 [Homo sapiens]
(1076 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|216548091 leucine zipper protein 1 [Homo sapiens] 2097 0.0
gi|216548085 leucine zipper protein 1 [Homo sapiens] 2097 0.0
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 322 9e-88
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 259 1e-68
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 259 1e-68
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 259 1e-68
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 94 9e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 91 6e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 90 1e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 90 1e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 90 1e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 90 1e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 90 1e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 85 3e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 85 3e-16
gi|16262452 cingulin [Homo sapiens] 83 1e-15
gi|45439327 periplakin [Homo sapiens] 83 1e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens] 82 3e-15
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 81 5e-15
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 81 5e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 81 6e-15
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 81 6e-15
gi|31982906 cingulin-like 1 [Homo sapiens] 80 8e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 80 1e-14
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 80 1e-14
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 79 3e-14
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 78 4e-14
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 78 5e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 78 5e-14
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 78 5e-14
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 2097 bits (5434), Expect = 0.0
Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT
Sbjct: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG
Sbjct: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
Query: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ
Sbjct: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
Query: 421 VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA
Sbjct: 421 VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
Query: 481 AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG
Sbjct: 481 AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
Query: 541 KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP
Sbjct: 541 KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
Query: 601 VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD
Sbjct: 601 VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
Query: 661 DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS
Sbjct: 661 DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
Query: 721 VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK
Sbjct: 721 VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
Query: 781 QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS
Sbjct: 781 QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
Query: 841 PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR
Sbjct: 841 PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
Query: 901 WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF
Sbjct: 901 WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
Query: 961 SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH
Sbjct: 961 SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
Query: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN
Sbjct: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 2097 bits (5434), Expect = 0.0
Identities = 1076/1076 (100%), Positives = 1076/1076 (100%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT
Sbjct: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG
Sbjct: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
Query: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ
Sbjct: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQ 420
Query: 421 VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA
Sbjct: 421 VSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPA 480
Query: 481 AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG
Sbjct: 481 AQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFG 540
Query: 541 KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP
Sbjct: 541 KRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAP 600
Query: 601 VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD
Sbjct: 601 VLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSD 660
Query: 661 DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS
Sbjct: 661 DDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKS 720
Query: 721 VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK
Sbjct: 721 VRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEK 780
Query: 781 QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS
Sbjct: 781 QKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSS 840
Query: 841 PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR
Sbjct: 841 PFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPVERNSHAPPAETIR 900
Query: 901 WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF
Sbjct: 901 WKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDF 960
Query: 961 SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH
Sbjct: 961 SELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNH 1020
Query: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN
Sbjct: 1021 SASMEEEGEDCTLSVYRQLHNSLDPSELPGKQGLPESGRVRAEERLRPTRPCAEEN 1076
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 322 bits (826), Expect = 9e-88
Identities = 224/582 (38%), Positives = 320/582 (54%), Gaps = 68/582 (11%)
Query: 9 ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
+ + +R LR KL L++R++ELEE KNLQKAE+EL +L+DK+ + E NSS++AE+E L
Sbjct: 324 QESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENL 383
Query: 69 RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFS 128
R+RVL +EGKDEEI + E CR +++KL+EEE+ ++EL+ E+E+LQKRM+ELEKLEEAFS
Sbjct: 384 RKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFS 443
Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKS 188
+SK++CTQL L+L +E+NLTK + +ELE+++ +VKELE SE RL+K E SL +L KLKS
Sbjct: 444 KSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKS 503
Query: 189 LTLSFVSERKYLNEKEKENEKLIKELTQ--KLEQNK----------------KMNRDYTR 230
T+ V ERK + EK K+ E+ + L + K+EQ K K+ +
Sbjct: 504 FTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEE 563
Query: 231 NASNLER------NDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKSENEKNRN- 282
NL R L+ E+ SS L K LD +++VE E TR +S
Sbjct: 564 KVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTC 623
Query: 283 QEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE 342
EDNK+K+L EIE+LK +++ E +E +L K + + + L+ + +EQ+K L+ QLEE
Sbjct: 624 PEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE 683
Query: 343 IKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR--- 399
IK QI K K +E GEV ++A L + R E K R +E K EL + +
Sbjct: 684 IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQ 743
Query: 400 -----ERLRNREFALNNENYSLSNRQVS---------------SPSFTNRRA--AKASHM 437
L+ R N+N ++ ++ PS RR +
Sbjct: 744 LQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTST 803
Query: 438 GVSTD--SGTQETKKTEDRFVPGSSQSEG-----------KKSREQPSVLSRYPPAAQEH 484
GV TD SG ++T F+ S Q E KK E+ SVL RYPPAA E
Sbjct: 804 GVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANEL 863
Query: 485 S--KAWKGTSKPGTESGLKGKVEKTTRTFSDTTH-GSVPSDP 523
+ K+W + E+G EK RT S H G V P
Sbjct: 864 TMRKSWIPWMRK-RENGPSITQEKGPRTNSSPGHPGEVVLSP 904
Score = 87.4 bits (215), Expect = 6e-17
Identities = 90/419 (21%), Positives = 182/419 (43%), Gaps = 65/419 (15%)
Query: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL----------------- 45
+FT+ E R + Q + + + +E K L K DEL+
Sbjct: 199 DFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHI 258
Query: 46 -----------DLQDKVIQAEGSNSSMLAEIEVLRQRVLRIE-GKDEEIKRAEDLCRLMK 93
DL K+ + E ++ ++ + RQ++L++E + + R M
Sbjct: 259 EQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMN 318
Query: 94 EKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISS 153
KL +E+ R+L+ ++ L +R+ ELE+ + +++ + +L + + + +
Sbjct: 319 AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMA 378
Query: 154 ELEMLRVKVKELESSEDRLDKTE---------------------------QSLASELEKL 186
E+E LR +V E+E ++ + KTE Q SELEKL
Sbjct: 379 EVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKL 438
Query: 187 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGI 246
+ SE L+ ++ + L K+L +LE K ++ + S LE+ +L ++D +
Sbjct: 439 EEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDL 498
Query: 247 ----SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQE-IEKLKTQ 301
S T+ + R+ + +++++ E R KN E KV D+ ++ IE+ K
Sbjct: 499 TKLKSFTVMLVDERK----NMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKL 554
Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
+K +EE++ + + ++L SE+ K+ L+ ++ +K ++ +E+E G
Sbjct: 555 LKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
Score = 80.9 bits (198), Expect = 6e-15
Identities = 87/346 (25%), Positives = 149/346 (43%), Gaps = 48/346 (13%)
Query: 27 LDELEEATKNLQKAEDELLDL--QDKVIQA--EGSNSSMLAEIEVLRQRVLRIEGKDEEI 82
+++ ++ T L++ + L L Q+K QA E N+ L ++ +DE +
Sbjct: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKL------------RDELV 241
Query: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
K L+ E+ E L + + + QK E EKL+ S+SK D +L
Sbjct: 242 KLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEV 301
Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
+ + + S E E + K+ ES +L L +E+L+ N+
Sbjct: 302 DFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEE-----------TNK 350
Query: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLD 262
++ E+ ++EL K+ + + N NL + L +E G +
Sbjct: 351 NLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEME---------------GKDE 395
Query: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDL 322
+ + E++ R E K +E++ K+L E+EKL+ ++ E LEE K KS+ L
Sbjct: 396 EITKTESQCR---ELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL 452
Query: 323 QDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSK 368
N E+N K L ++LE +K ++ KELE E E A LS K
Sbjct: 453 HLNLEKEKNLTKDLLNELEVVKSRV---KELECSESRLEKAELSLK 495
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/319 (22%), Positives = 130/319 (40%), Gaps = 32/319 (10%)
Query: 75 IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKND 133
I G E +ED + K +E++ + ++R K E E K +++ SK D
Sbjct: 23 IIGNAGEKSLSEDAKKKKKSNRKEDDVMA---SGTVKRHLKTSGECERKTKKSLELSKED 79
Query: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELE----SSED----RLDKTEQSLASELEK 185
QL + E + + L+ + K + LE S+E R+ + LA E
Sbjct: 80 LIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSI 139
Query: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
+ + +SE L EK+KE + + E E+ + N + + + D
Sbjct: 140 GEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDD 199
Query: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT----Q 301
++ L + R K K +E E ++ EK + NK++D E+ KLK+
Sbjct: 200 FTNLLEQERERLK------KLLEQEKAYQARKEKENAKRLNKLRD---ELVKLKSFALML 250
Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEE-----IKLQIKKQKELENG 356
+ + E+L K DL E+ K K + S+ +E +KL++ + +
Sbjct: 251 VDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRF 310
Query: 357 EVEGED--AFLSSKGRHER 373
E E+ A L+++ H R
Sbjct: 311 SQEHEEMNAKLANQESHNR 329
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 259 bits (662), Expect = 1e-68
Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
K D T+ +L +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 548 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 606
Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E
Sbjct: 607 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 666
Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
++K + L+ +LE +K+++ K K E E HE+ F+ E + S H
Sbjct: 667 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 715
Query: 390 AREL 393
+RE+
Sbjct: 716 SREV 719
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
Query: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
Score = 77.8 bits (190), Expect = 5e-14
Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)
Query: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
EF E R + Q + + ++ +E K + ++EL L+ + +
Sbjct: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
Query: 63 AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
A++ + RQ++ L K+ K A L + +++EEE L+ E
Sbjct: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
L+ ++ D + L E + +++ +L L ++ ELE + L K E+ L
Sbjct: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
Query: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
EK+ + RK + + E ++E+LIK Q + NK++ R+
Sbjct: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
L+ D ++E K S+R L+ L+ N+++ + + K N +E K L+
Sbjct: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
Query: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
QE+E LK +IK E++E L+K +K L+ + ++ K ++ +L+ K + K
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
Q +VE ++ E TK R S+ V + + S +R+ L+N+ A
Sbjct: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
Query: 409 LNNENYSLSNR 419
+ L +R
Sbjct: 574 EEEKGNDLLSR 584
Score = 70.5 bits (171), Expect = 8e-12
Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)
Query: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
K E R++ + L E++ + + E +K +EK +E +CL
Sbjct: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
E L K I E +K E E +K +L EL KLKS L V E++ L
Sbjct: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
Query: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
+ + I+ELT ++ ++ + TR L+ + +D I +
Sbjct: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
Query: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
L +++S+ + L + + E ++ + + +++D+ + E
Sbjct: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
Query: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
+E+L+ ++ E +EEL KM+ + DL E ++K ++E++ +I ++LE
Sbjct: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
Query: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
+ + + S K E+ + + R + RL EF L +
Sbjct: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
Query: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
L+ + + F + R +++ KKTED+ SSQ + ++++
Sbjct: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
Score = 70.5 bits (171), Expect = 8e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
+ NRD R NL + R S PS RR
Sbjct: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 259 bits (662), Expect = 1e-68
Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 70 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 247
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK
Sbjct: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 307
Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
K D T+ +L +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 308 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 366
Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E
Sbjct: 367 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 426
Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
++K + L+ +LE +K+++ K K E E HE+ F+ E + S H
Sbjct: 427 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 475
Query: 390 AREL 393
+RE+
Sbjct: 476 SREV 479
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 210 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269
Query: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 270 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 329
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 330 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 389
Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 390 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 436
Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 437 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 555
Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 556 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 590
Score = 70.5 bits (171), Expect = 8e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
Query: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 392
Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 393 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512
Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
+ NRD R NL + R S PS RR
Sbjct: 513 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 549
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/360 (22%), Positives = 159/360 (44%), Gaps = 39/360 (10%)
Query: 80 EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK--------LEEAFSRSK 131
+E +R L ++K++E +E +++ + R+ E E+ L+ ++
Sbjct: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK---- 187
D + L E + +++ +L L ++ ELE + L K E+ L EK+
Sbjct: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
Query: 188 ---SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
+ RK + + E ++E+LIK Q + NK++ R+ L+ D ++E
Sbjct: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------TLQSKDFKLE- 176
Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLNQEIEKLKTQIK 303
K S+R L+ L+ N+++ + + K N +E K L+QE+E LK +IK
Sbjct: 177 ------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
Query: 304 HFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
E++E L+K +K L+ + ++ K ++ +L+ K + K Q +VE
Sbjct: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDKLQAASSQLQVE 288
Query: 360 GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNR 419
++ E TK R S+ V + + S +R+ L+N+ A + L +R
Sbjct: 289 QNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKAEEEKGNDLLSR 344
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/342 (20%), Positives = 136/342 (39%), Gaps = 71/342 (20%)
Query: 136 QLCLSLNEERNLT---KKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
QL L + + LT K+ ++L + +V+E E RL+K Q+ ++ + + ++
Sbjct: 12 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 71
Query: 193 FVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPS 252
++ N + ++ + +LE+ + R +++ + E G + +
Sbjct: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 131
Query: 253 KESRRKGGLDY------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
E RK LD L ++E + R+ + K +E + KD E+EKL +I E
Sbjct: 132 VEELRKRVLDMEGKDEELIKMEEQCRDLN---KRLERETLQSKDFKLEVEKLSKRIMALE 188
Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS 366
LE+ K K + L+ N E+ K L+ +LE +K++IK+ + +E+
Sbjct: 189 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES----------- 237
Query: 367 SKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSF 426
RL EF L + L+ + + F
Sbjct: 238 ----------------------------------RLEKTEFTLKED---LTKLKTLTVMF 260
Query: 427 TNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
+ R + ++ KKTED+ SSQ + ++++
Sbjct: 261 VDERKTMS-----------EKLKKTEDKLQAASSQLQVEQNK 291
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 259 bits (662), Expect = 1e-68
Identities = 155/424 (36%), Positives = 260/424 (61%), Gaps = 45/424 (10%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------------- 222
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
Query: 223 KMNRD-------YTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNK 274
K D T+ +L +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 548 KSKTDVEEKMYSVTKERDDL-KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNK 606
Query: 275 SENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE 329
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E
Sbjct: 607 LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 666
Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT 389
++K + L+ +LE +K+++ K K E E HE+ F+ E + S H
Sbjct: 667 RDKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHL 715
Query: 390 AREL 393
+RE+
Sbjct: 716 SREV 719
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
Query: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
Query: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
Query: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
Score = 77.8 bits (190), Expect = 5e-14
Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)
Query: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
EF E R + Q + + ++ +E K + ++EL L+ + +
Sbjct: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
Query: 63 AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
A++ + RQ++ L K+ K A L + +++EEE L+ E
Sbjct: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
L+ ++ D + L E + +++ +L L ++ ELE + L K E+ L
Sbjct: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
Query: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
EK+ + RK + + E ++E+LIK Q + NK++ R+
Sbjct: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
L+ D ++E K S+R L+ L+ N+++ + + K N +E K L+
Sbjct: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
Query: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
QE+E LK +IK E++E L+K +K L+ + ++ K ++ +L+ K + K
Sbjct: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
Q +VE ++ E TK R S+ V + + S +R+ L+N+ A
Sbjct: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
Query: 409 LNNENYSLSNR 419
+ L +R
Sbjct: 574 EEEKGNDLLSR 584
Score = 70.5 bits (171), Expect = 8e-12
Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)
Query: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
K E R++ + L E++ + + E +K +EK +E +CL
Sbjct: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
E L K I E +K E E +K +L EL KLKS L V E++ L
Sbjct: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
Query: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
+ + I+ELT ++ ++ + TR L+ + +D I +
Sbjct: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
Query: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
L +++S+ + L + + E ++ + + +++D+ + E
Sbjct: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
Query: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
+E+L+ ++ E +EEL KM+ + DL E ++K ++E++ +I ++LE
Sbjct: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
Query: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
+ + + S K E+ + + R + RL EF L +
Sbjct: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
Query: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
L+ + + F + R +++ KKTED+ SSQ + ++++
Sbjct: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
Score = 70.5 bits (171), Expect = 8e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
+ NRD R NL + R S PS RR
Sbjct: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 93.6 bits (231), Expect = 9e-19
Identities = 119/502 (23%), Positives = 215/502 (42%), Gaps = 99/502 (19%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
+R K + RL E+E L E L LQ++ +QAE + + AE E LR R +
Sbjct: 857 VREKQLAAENRLTEMETLQSQLMA---EKLQLQEQ-LQAE---TELCAEAEELRAR---L 906
Query: 76 EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
K +E+ E++C ++ ++EEEE + L++E +++Q+ + ELE+
Sbjct: 907 TAKKQEL---EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE------------- 950
Query: 136 QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
L EE + +K+ E K+K+LE + L+ LA E + L+ F +
Sbjct: 951 ----QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 196 ERKYLNEKEK-------ENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS 248
EK K ++E +I +L ++L + +K ++ + LE + + D I+
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 249 ----------TLPSKE--------------SRRKGGLDYLKQVE---NETRNKSENEK-N 280
L KE +++ L ++++E +E + E+E+ +
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 281 RNQEDNKVKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN---- 333
RN+ + + +DL +E+E LKT+++ + ++EL+ + + ++ L E+ K
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 334 ------------KLLASQLEE---IKLQIKKQK---ELENGEVEGE-DAFLSSKG--RHE 372
+ LA QLE+ +K ++K K E E GE+ E L KG H+
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHK 1246
Query: 373 RTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAA 432
R K E V K E +++ + L+N LS S T +A
Sbjct: 1247 RKKVEAQLQELQV-KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 433 KASHMGVSTDSGTQETKKTEDR 454
S + TQE + E+R
Sbjct: 1306 LESQL-----QDTQELLQEENR 1322
Score = 82.0 bits (201), Expect = 3e-15
Identities = 97/420 (23%), Positives = 184/420 (43%), Gaps = 83/420 (19%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLAEIE 66
A + ++ +Q L +L+E E A + LQ E +L L+++ I E N + E +
Sbjct: 936 AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995
Query: 67 VLRQRVLRIEGK-DEEIKRAEDLCRL----------MKEKLEEEENLTRELKS------- 108
+L R+ EE ++++ L +L ++E+L EE +EL+
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 109 -------EIERLQKRMAEL--------EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISS 153
+I LQ ++AEL E+L+ A +R + + Q ++L + R L +IS
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 154 ELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSL---TLSFVSERKYLNEKEKENEKL 210
L+ ++ +S ++ +K ++ L ELE LK+ TL + ++ L K ++ +
Sbjct: 1116 ----LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 211 IK--------------------------ELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
+K EL ++LEQ K++ + + LE + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 245 GISSTLPSK---ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
+ L K E +RK L++++ + +E E+ R + +KV L E++ +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKF---NEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 302 IKHFESLEEEL-KKMKSKNNDLQD--NYLSEQNKNKLLAS----QLEEIKLQIKKQKELE 354
+ +S +L K + + LQD L E+N+ KL S Q+E+ K ++Q E E
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Score = 78.2 bits (191), Expect = 4e-14
Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 63/501 (12%)
Query: 2 AEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM 61
+E K A + L+ K R EL + LQ D + L + Q++ +S +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL---LSQSDSKSSKL 1299
Query: 62 LAEIEVLR------QRVLRIEGKDE-----EIKRAEDLCRLMKEKLEEEENLTRELKSEI 110
+ L Q +L+ E + + ++K+ ED +E+LEEEE L+ +I
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
L ++A+++K K + + CL EE + +K+ +LE L + +E ++ D
Sbjct: 1360 ATLHAQVADMKK--------KMEDSVGCLETAEE--VKRKLQKDLEGLSQRHEEKVAAYD 1409
Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTR 230
+L+KT+ L EL+ L + + + + EK K+ Q L + K ++ Y
Sbjct: 1410 KLEKTKTRLQQELDDL-------LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 231 NASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
E ++E K L + +E K+E E+ Q +++D
Sbjct: 1463 ERDRAEAE-------------AREKETKA-LSLARALEEAMEQKAELERLNKQFRTEMED 1508
Query: 291 LNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ 346
L + + + E +LE+++++MK++ +L+D + ++ L L+ +K Q
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568
Query: 347 IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406
++ + + + E + L + R + + S++ ++L L++ E
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD-----LKDLE 1623
Query: 407 FALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGK- 465
+++ N NR + +A M D T+ + + + + ++E K
Sbjct: 1624 AHIDSAN---KNRDEAIKQLRKLQAQMKDCMRELDD-----TRASREEILAQAKENEKKL 1675
Query: 466 KSREQPSVLSRYPPAAQEHSK 486
KS E + + AA E +K
Sbjct: 1676 KSMEAEMIQLQEELAAAERAK 1696
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/262 (23%), Positives = 107/262 (40%), Gaps = 48/262 (18%)
Query: 27 LDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKD----EEI 82
L + +E K L+ E E++ LQ+++ AE + E + L + GK EE
Sbjct: 1665 LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL-----------EKLEEAFSRSK 131
+R E ++E+LEEE+ T + +++ ++ ++ +K E A + +
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 132 NDCTQLCLSLNE-ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL----EKL 186
+L + L E E + K + + L K+ +LE D K Q+ ++ +KL
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 187 KSLTLSFVSERK---------------------YLNEKEKENE-------KLIKELTQKL 218
K + L ER+ L E E+E + KL +EL
Sbjct: 1845 KDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT 1904
Query: 219 EQNKKMNRDYTRNASNLERNDL 240
E MNR+ + + L R DL
Sbjct: 1905 ETADAMNREVSSLKNKLRRGDL 1926
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/383 (19%), Positives = 156/383 (40%), Gaps = 61/383 (15%)
Query: 19 KLQSLSRRLDE-LEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG 77
+L+ R L++ +EE L++ EDEL +D ++ E + +M A+ E R R E
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGRDEQ 1579
Query: 78 KDEEIKRAEDLCRLMKEKLEEE--------------ENLTRELKSEIERLQKRMAELEKL 123
+E+ K+ R M+ +LE+E E ++L++ I+ K E K
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 124 EEAFSRSKNDCT-----------QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
DC ++ E K + +E+ L+ ++ E ++ +
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 173 DKTEQSLASELEKLKSLTLSFVSERKYLN----------EKEKENEKLIKELTQKLE-QN 221
+ LA E+ + E++ L E+E+ N +LI + +K Q
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759
Query: 222 KKMNRDYTRNASN----------LERNDLRIEDGISSTLPSKESRRKGGLDYLK------ 265
++N D S+ LER + ++ + + +S+ K + L+
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 266 --QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE----LKKMKSKN 319
Q++NET+ + K + + K+KD+ +++ + + ++ ++ LK++K +
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879
Query: 320 NDLQDNYLSEQNKNKLLASQLEE 342
+ ++ + L +LE+
Sbjct: 1880 EEAEEEAQRANASRRKLQRELED 1902
Score = 37.4 bits (85), Expect = 0.077
Identities = 38/175 (21%), Positives = 77/175 (44%), Gaps = 15/175 (8%)
Query: 29 ELEEATKN---LQKAEDELLDLQDKVIQAEGS-NSSMLAEIEVLRQRVLRIEGK-DEEIK 83
E A KN Q+ E + +L+ K+ + EG+ S A I L ++ ++E + D E K
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 84 RAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNE 143
+ C+ ++ ++LK + ++ E+ ++ ++ QL L E
Sbjct: 1829 ERQAACKQVRRT-------EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881
Query: 144 ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
++ ++ L+ +ELE + + D + ++S KL+ L FV R+
Sbjct: 1882 AEEEAQRANASRRKLQ---RELEDATETADAMNREVSSLKNKLRRGDLPFVVPRR 1933
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 90.9 bits (224), Expect = 6e-18
Identities = 101/405 (24%), Positives = 191/405 (47%), Gaps = 45/405 (11%)
Query: 6 SYKETASS-RHLRFKLQSLSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAEGSNSSML 62
S KET+S + F+ + + + L+ +E + ++ E+EL L+ +++++Q + +N +
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 63 AE-IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE---------EEENLTRELKSEIER 112
E IE L Q +E ++ ++K+ D + + +LE +EENL EL+ +E
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVES 712
Query: 113 LQ---KRMAELE----KLEEAFSRSKNDCTQLCLSLNEERNL----------TKKISSEL 155
L+ +MA+L+ +LE + K L S + L +++ L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 156 EMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELT 215
E K+++LES L+ Q+L LE+LK + K E+E +L K+
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 216 QKLEQNKKMNRDYTRNASNLERNDLRIE--DGISSTLPSKESRRKGGLDYLKQVENETRN 273
Q ++NK++ + + LE N+++I + + TL + K LK++E E +
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK- 891
Query: 274 KSENEKNRNQEDNKVKDLNQEI--EKLKTQIKH--FESLEEELKKM-KSKNNDLQDNYLS 328
E K + + L +++ EKLKTQ + E L EL+K+ +K L D +
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 329 EQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
+ ++ KLL S+LE +KK E++ ++ +A L + +
Sbjct: 950 DDSRYKLLESKLES---TLKKSLEIKEEKIAALEARLEESTNYNQ 991
Score = 85.5 bits (210), Expect = 2e-16
Identities = 104/441 (23%), Positives = 188/441 (42%), Gaps = 84/441 (19%)
Query: 5 TSYKETASSRHLRFKLQSL-SRRLDELEEATKNLQKAEDELLDLQD-------KVIQAEG 56
TS A + L ++ L S RL +LE ++L K +EL D K+++ E
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 57 SNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR-LMKEKLEEE-------ENLTRELK- 107
N + ++E+L +++ + + ++ ++L + LMKEK + E EN R++K
Sbjct: 499 ENQRLSKKVEILENEIVQ---EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555
Query: 108 --SEIERLQK---------------RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
E E L + R+ ++EK + S + + + E+ KK
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
+ + +ELE+ L+K + L ++ LK + + +E E+EN KL
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 211 ------IKELTQKLEQNKKMNRDYTRNASNLERN------------DLRIEDGISSTLPS 252
K LT +LE +K N L RN L++E + L S
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE---NKELES 732
Query: 253 KESRRKGGLDYLK----------------QVENETRNKSENEKNR--NQEDNKVKDLNQE 294
++ + K GL+ LK +EN+ K+ N+ Q +++++DL E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 295 -------IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
+E+LK K E LE+E K ++ + + L+ + + +NK L Q EIK
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTT 851
Query: 348 KKQKELENGEVEGEDAFLSSK 368
++ ++ G +E E+ LS +
Sbjct: 852 LEENNVKIGNLEKENKTLSKE 872
Score = 68.9 bits (167), Expect = 2e-11
Identities = 95/444 (21%), Positives = 191/444 (43%), Gaps = 101/444 (22%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEAT-------KNLQKAEDELLDLQDKVIQAE----- 55
K T S +HL EL +A + L++ ++LLD + ++ Q E
Sbjct: 241 KRTESRQHLSV----------ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290
Query: 56 --GSNSSMLA----------EIEVLRQRVLRIEGKDEEIK--------------RAEDL- 88
N ++L+ E++ LR++ +R++ + E+ R E+L
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 89 -------------------CRLMKEKLEEEENLTRELKSEI-----------ERLQKRMA 118
R +KL E E +LK+++ +++++ M
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQ 177
E LE A +S ++ L L + ++ + + L +V EL SS +L+ Q
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
SL +E+L++ S + + EKEN++L K++ + LE + +N NL +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV-EILENEIVQEKQSLQNCQNLSK 529
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK---SENEKNRNQEDNKVKDLNQE 294
+ ++ + + T+ + + + L+Q ENE N+ S ++++ + +VKD+ +E
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 295 IEKLKTQIKHFES-----------LEEELKKMKSKN---NDLQDNYLSEQNKNKLLASQL 340
+ L IK S +++EL+ K K +L++ + +N+LL ++
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 341 EEIKLQIKKQK--ELENGEVEGED 362
+K+ +K + E EN E+E E+
Sbjct: 649 TNLKITCEKIEALEQENSELEREN 672
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/333 (19%), Positives = 140/333 (42%), Gaps = 17/333 (5%)
Query: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
K+L+ E+++ L+ ++ ++ N + E++ +++ ++ + +E + + + E
Sbjct: 967 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSE 154
+ E ++E E+ +++ R+ E+E+ K L + N + ++
Sbjct: 1027 DNKWERE-SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---NLQAQ 1082
Query: 155 LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEKENEKL 210
+ L+ + L+ L L E L S + S +++ L + E ENE +
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
IKE + +D+ + ER E IS K + + +VE+
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN------LEVEHR 1196
Query: 271 TRNKSENE--KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLS 328
N+ K + Q ++ K L E EK+ + K+ E++ E KK+ +N+ L Y
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
Query: 329 EQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
+ ++L + + +K + K LE +E E
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSK-LEQTRLEAE 1288
Score = 48.5 bits (114), Expect = 3e-05
Identities = 123/574 (21%), Positives = 221/574 (38%), Gaps = 91/574 (15%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDE 80
+SL + L+ A KNL+ +L D +++++ +G + ++V ++++L +E K+
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNH 1233
Query: 81 EIKRAE--DLC-------RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
E AE LC + L+E E L + K+ L E +LE FS+ K
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 132 NDCTQLCLS---LNEERNLTKKISSELEMLRVKVKELESSEDRLDKTE----QSLASELE 184
QL ++ LN + L ++ LE E + LD+ + Q+ +
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLE---------EENRHLLDQIQTLMLQNRTLLEQ 1344
Query: 185 KLKSLTLSFVSERKY---LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASN------- 234
++S L V +R+Y LNE ++ EKL +++ ++Q K + R N
Sbjct: 1345 NMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI---MDQYKFYDPSPPRRRGNWITLKMR 1401
Query: 235 ---LERNDLRIEDGISSTL-PSKESRRKGGLDYLKQVENETRNKSENEKNRNQ-----ED 285
+ D+ E S TL P++ +G L Q ++ + N Q +
Sbjct: 1402 KLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKS 1461
Query: 286 NKVKDLNQEIEKLKTQIKHFESLE-----------EELKKMKSKNNDL-------QDNYL 327
+ + DL Q + E+LE +EL M + +
Sbjct: 1462 STMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFR 1521
Query: 328 SEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSK 387
S+Q N + E+I Q V G RT + AS+ +
Sbjct: 1522 SKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSG---RTSTSNSNNNASLHE 1578
Query: 388 HTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQE 447
A ++ Q + + + EF+L +++ + S+ SSP +R ++S + S T E
Sbjct: 1579 VKAGAVNNQSRPQSHSSGEFSLLHDHEAWSS-SGSSPIQYLKRQTRSSPVLQHKISETLE 1637
Query: 448 TKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKT 507
++ + GS SE + +E +K K ++ L +V K+
Sbjct: 1638 SR--HHKIKTGSPGSE----------VVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKS 1685
Query: 508 TRTFSDTTHGSVPSDPLGRADKASDTSSETVFGK 541
SV SD LG+ S + +V GK
Sbjct: 1686 L---------SVSSDFLGKDKPVSCGLARSVSGK 1710
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 89.7 bits (221), Expect = 1e-17
Identities = 100/404 (24%), Positives = 188/404 (46%), Gaps = 44/404 (10%)
Query: 6 SYKETASS-RHLRFKLQSLSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAEGSNSSML 62
S KET+S + F+ + + + L+ +E + ++ E+EL L+ +++++Q + +N +
Sbjct: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT 654
Query: 63 AE-IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE---------EEENLTRELKSEIER 112
E IE L Q +E ++ ++K+ D + + +LE +EENL EL+ +E
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL--ELRRNVES 712
Query: 113 LQ---KRMAELE----KLEEAFSRSKNDCTQLCLSLNEERNL----------TKKISSEL 155
L+ +MA+L+ +LE + K L S + L +++ L
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 156 EMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELT 215
E K+++LES L+ Q+L LE+LK + K E+E +L K+
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 216 QKLEQNKKMNRDYTRNASNLERNDLRIE--DGISSTLPSKESRRKGGLDYLKQVENETRN 273
Q ++NK++ + + LE N+++I + + TL + K LK++E E +
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK- 891
Query: 274 KSENEKNRNQEDNKVKDLNQEI--EKLKTQIKH--FESLEEELKKMKSKNNDLQDNYLSE 329
E K + + L +++ EKLKTQ + E L EL+K+ L + S
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 330 QNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
++ KLL S+LE +KK E++ ++ +A L + +
Sbjct: 950 DDRYKLLESKLES---TLKKSLEIKEEKIAALEARLEESTNYNQ 990
Score = 85.5 bits (210), Expect = 2e-16
Identities = 104/441 (23%), Positives = 188/441 (42%), Gaps = 84/441 (19%)
Query: 5 TSYKETASSRHLRFKLQSL-SRRLDELEEATKNLQKAEDELLDLQD-------KVIQAEG 56
TS A + L ++ L S RL +LE ++L K +EL D K+++ E
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 57 SNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCR-LMKEKLEEE-------ENLTRELK- 107
N + ++E+L +++ + + ++ ++L + LMKEK + E EN R++K
Sbjct: 499 ENQRLSKKVEILENEIVQ---EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI 555
Query: 108 --SEIERLQK---------------RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
E E L + R+ ++EK + S + + + E+ KK
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL 210
+ + +ELE+ L+K + L ++ LK + + +E E+EN KL
Sbjct: 616 ELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 211 ------IKELTQKLEQNKKMNRDYTRNASNLERN------------DLRIEDGISSTLPS 252
K LT +LE +K N L RN L++E + L S
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLE---NKELES 732
Query: 253 KESRRKGGLDYLK----------------QVENETRNKSENEKNR--NQEDNKVKDLNQE 294
++ + K GL+ LK +EN+ K+ N+ Q +++++DL E
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 295 -------IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
+E+LK K E LE+E K ++ + + L+ + + +NK L Q EIK
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKDTT 851
Query: 348 KKQKELENGEVEGEDAFLSSK 368
++ ++ G +E E+ LS +
Sbjct: 852 LEENNVKIGNLEKENKTLSKE 872
Score = 68.9 bits (167), Expect = 2e-11
Identities = 95/444 (21%), Positives = 191/444 (43%), Gaps = 101/444 (22%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEAT-------KNLQKAEDELLDLQDKVIQAE----- 55
K T S +HL EL +A + L++ ++LLD + ++ Q E
Sbjct: 241 KRTESRQHLSV----------ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290
Query: 56 --GSNSSMLA----------EIEVLRQRVLRIEGKDEEIK--------------RAEDL- 88
N ++L+ E++ LR++ +R++ + E+ R E+L
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 89 -------------------CRLMKEKLEEEENLTRELKSEI-----------ERLQKRMA 118
R +KL E E +LK+++ +++++ M
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSE-DRLDKTEQ 177
E LE A +S ++ L L + ++ + + L +V EL SS +L+ Q
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
SL +E+L++ S + + EKEN++L K++ + LE + +N NL +
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV-EILENEIVQEKQSLQNCQNLSK 529
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK---SENEKNRNQEDNKVKDLNQE 294
+ ++ + + T+ + + + L+Q ENE N+ S ++++ + +VKD+ +E
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQ-ENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 295 IEKLKTQIKHFES-----------LEEELKKMKSKN---NDLQDNYLSEQNKNKLLASQL 340
+ L IK S +++EL+ K K +L++ + +N+LL ++
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 341 EEIKLQIKKQK--ELENGEVEGED 362
+K+ +K + E EN E+E E+
Sbjct: 649 TNLKITCEKIEALEQENSELEREN 672
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/333 (19%), Positives = 140/333 (42%), Gaps = 17/333 (5%)
Query: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
K+L+ E+++ L+ ++ ++ N + E++ +++ ++ + +E + + + E
Sbjct: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSE 154
+ E ++E E+ +++ R+ E+E+ K L + N + ++
Sbjct: 1026 DNKWERE-SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---NLQAQ 1081
Query: 155 LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEKENEKL 210
+ L+ + L+ L L E L S + S +++ L + E ENE +
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
Query: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
IKE + +D+ + ER E IS K + + +VE+
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN------LEVEHR 1195
Query: 271 TRNKSENE--KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLS 328
N+ K + Q ++ K L E EK+ + K+ E++ E KK+ +N+ L Y
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 329 EQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
+ ++L + + +K + K LE +E E
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSK-LEQTRLEAE 1287
Score = 49.7 bits (117), Expect = 1e-05
Identities = 126/602 (20%), Positives = 229/602 (38%), Gaps = 79/602 (13%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDE 80
+SL + L+ A KNL+ +L D +++++ +G + ++V ++++L +E K+
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML-LENKNH 1232
Query: 81 EIKRAE--DLC-------RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
E AE LC + L+E E L + K+ L E +LE FS+ K
Sbjct: 1233 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1292
Query: 132 NDCTQLCLS---LNEERNLTKKISSELEMLRVKVKELESSEDRLDKTE----QSLASELE 184
QL ++ LN + L ++ LE E + LD+ + Q+ +
Sbjct: 1293 EQYQQLDITSTKLNNQCELLSQLKGNLE---------EENRHLLDQIQTLMLQNRTLLEQ 1343
Query: 185 KLKSLTLSFVSERKY---LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASN------- 234
++S L V +R+Y LNE ++ EKL +++ ++Q K + R N
Sbjct: 1344 NMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI---MDQYKFYDPSPPRRRGNWITLKMR 1400
Query: 235 ---LERNDLRIEDGISSTL-PSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
+ D+ E S TL P++ +G L Q+ ++ S + + + ED +
Sbjct: 1401 KLIKSKKDINRERQKSLTLTPTRSDSSEGFL----QLPHQDSQDSSSVGSNSLEDGQTLG 1456
Query: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
+ ++ + ++ KMK+ Y + N L+ S + L +
Sbjct: 1457 TKKSSMVALKRLPFLRNRPKDKDKMKA-------CYRRSMSMNDLVQSMV----LAGQWT 1505
Query: 351 KELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALN 410
EN EV D + K R E A TA S + R+++ N
Sbjct: 1506 GSTENLEV--PDDISTGKRRKE--------LGAMAFSTTAINFSTVNSSAGFRSKQLVNN 1555
Query: 411 NENYS---LSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKS 467
+ S +S + VS S T R + S DSG T + + ++ +
Sbjct: 1556 KDTTSFEDISPQGVSDDSSTGSRV--HASRPASLDSGRTSTSNSNNNASLHEVKAGAVNN 1613
Query: 468 REQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHG-SVPSDPLGR 526
+ +P S + +AW + + +++ TR+ H S +
Sbjct: 1614 QSRPQSHSSGEFSLLHDHEAWSSSGSSPIQ-----YLKRQTRSSPVLQHKISETLESRHH 1668
Query: 527 ADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAAN 586
K SE V ++ N Q +S + + S SS+ L K K +
Sbjct: 1669 KIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSC 1728
Query: 587 GL 588
GL
Sbjct: 1729 GL 1730
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 89.7 bits (221), Expect = 1e-17
Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
+ + + DEL++ + QKAE+EL +L+ K Q E N + + AE E +R
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 910
Query: 71 RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
+R+ K +E+ E++ M+ +LEEEE+ ++L++E +++ ++M +LE+ EE +
Sbjct: 911 --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
R K L L KK+ E+ ++ KE + E+R+ +LA E E
Sbjct: 966 RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 185 KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
K K+LT S +SE + +KE+++ + +++L +KLE + + D +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 235 LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
L+ + E+ + + L + +++ L ++++E + E+ RN+ + +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 288 VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
+DL +E+E LKT+++ + ++EL+ + + + L E+ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 334 -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
+ L QLE+ K + K + +E E+A L+ + + G + K
Sbjct: 1201 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1254
Query: 389 TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
E Q + + + E A LN++ + L N S N KA + S +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 446 QETKKTED 453
+ + T++
Sbjct: 1315 SQLQDTQE 1322
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
+E+E T L +AE + + L V S SS L + + L Q EE ++ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1333
Query: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
+ +++ EE +L +L E+E Q + L S SK ++
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
K+ E+E L + +E ++ D+L+KT+ L EL+ L + ++R+ ++ EK+
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1450
Query: 208 EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
K + L ++ + K + R A E L + + L +KE +
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
++E+ +K + KN ++ + + L ++E++KTQ+ E LE+EL+ + L+
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1567
Query: 325 NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
N L Q + L A + + + + Q++L E E ED + + K G
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627
Query: 382 EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
+ + +A E Q ++ + + ++F E+ S ++ + + N + AK+
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Score = 79.3 bits (194), Expect = 2e-14
Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
K R L +L++L L++ ++T Q K E E+ L+ + + S+ + +
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 64 EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
E+ Q V + + E+ KRA+ K+ LE+E +L EL+ + Q+ + +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
KLE ++ C+ + E + K+ +E+E + + E E +L K SL+S
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 182 EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+L E L+ T ++ L + E+E L +L +++E + + R + L
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
+ +++D S+ +E +++ + K++EN T+ +K E KNR Q+ D+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 287 KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
V DL+ Q + L+ + + F+ L E K + SK D +D +E + K LA
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 340 LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
LEE L+ K++ E N ++ E + +SSK
Sbjct: 1492 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1520
Score = 68.6 bits (166), Expect = 3e-11
Identities = 113/515 (21%), Positives = 205/515 (39%), Gaps = 80/515 (15%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
A +R K SL+R L+E EA + L+ KAE E L D+ V + E S
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 60 SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
++ ++E ++ ++E ++E++ ED KL E N+ + LK + ER LQ R
Sbjct: 1536 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1585
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
+ E+ R ++ L +ER ++ + L +K+LE D K +
Sbjct: 1586 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 179 LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
+L KL++ F E R + KENEK K L L Q ++ +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
R ++LE+ +L E ++S+L + + + ++ E + N ++V+
Sbjct: 1703 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 290 DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Q+ E+L ++ S LE + K+++SK ++++ + ++K K +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1817
Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR----------HERTKFRGHGSEASVSKH 388
LE Q+++Q E E E + L K + ER + +A
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 389 TARELSPQ-----------HKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
++L Q + R RE E+ R+V++ RR + S +
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937
Query: 438 G---------VSTDSGTQETKKTEDRFVPGSSQSE 463
+ G++E T D G+ SE
Sbjct: 1938 PSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1972
Score = 63.9 bits (154), Expect = 8e-10
Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
+L++ ++EE++ ED + KE+ ++ EN +EL+ + +L + L++ +A +
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
+ ++ + L ++ ++I E+E LE EDR Q L +E +K+ L
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 953
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+ L E+E +KL E + KK+ +++ + D ++ L
Sbjct: 954 DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 997
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
SKE RK + + + + E KN + NK + + E+E +LK + K + LE+
Sbjct: 998 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 311 ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
+K++ +D + L +Q+ E+K+Q+ KK++EL+ +D
Sbjct: 1056 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 370 RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
++ + GH S+ S+ AR + + KR+ E AL E L + S+ +
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1164
Query: 426 FTNRRAAKASHMGVSTDSGTQETKKTE 452
RA + + V + +ET+ E
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHE 1191
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 89.7 bits (221), Expect = 1e-17
Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
+ + + DEL++ + QKAE+EL +L+ K Q E N + + AE E +R
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 917
Query: 71 RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
+R+ K +E+ E++ M+ +LEEEE+ ++L++E +++ ++M +LE+ EE +
Sbjct: 918 --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
R K L L KK+ E+ ++ KE + E+R+ +LA E E
Sbjct: 973 RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 185 KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
K K+LT S +SE + +KE+++ + +++L +KLE + + D +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 235 LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
L+ + E+ + + L + +++ L ++++E + E+ RN+ + +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 288 VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
+DL +E+E LKT+++ + ++EL+ + + + L E+ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 334 -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
+ L QLE+ K + K + +E E+A L+ + + G + K
Sbjct: 1208 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1261
Query: 389 TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
E Q + + + E A LN++ + L N S N KA + S +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 446 QETKKTED 453
+ + T++
Sbjct: 1322 SQLQDTQE 1329
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
+E+E T L +AE + + L V S SS L + + L Q EE ++ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1340
Query: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
+ +++ EE +L +L E+E Q + L S SK ++
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
K+ E+E L + +E ++ D+L+KT+ L EL+ L + ++R+ ++ EK+
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1457
Query: 208 EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
K + L ++ + K + R A E L + + L +KE +
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
++E+ +K + KN ++ + + L ++E++KTQ+ E LE+EL+ + L+
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1574
Query: 325 NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
N L Q + L A + + + + Q++L E E ED + + K G
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634
Query: 382 EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
+ + +A E Q ++ + + ++F E+ S ++ + + N + AK+
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Score = 79.3 bits (194), Expect = 2e-14
Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
K R L +L++L L++ ++T Q K E E+ L+ + + S+ + +
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 64 EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
E+ Q V + + E+ KRA+ K+ LE+E +L EL+ + Q+ + +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
KLE ++ C+ + E + K+ +E+E + + E E +L K SL+S
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 182 EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+L E L+ T ++ L + E+E L +L +++E + + R + L
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
+ +++D S+ +E +++ + K++EN T+ +K E KNR Q+ D+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 287 KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
V DL+ Q + L+ + + F+ L E K + SK D +D +E + K LA
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 340 LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
LEE L+ K++ E N ++ E + +SSK
Sbjct: 1499 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1527
Score = 68.6 bits (166), Expect = 3e-11
Identities = 113/515 (21%), Positives = 205/515 (39%), Gaps = 80/515 (15%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
A +R K SL+R L+E EA + L+ KAE E L D+ V + E S
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 60 SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
++ ++E ++ ++E ++E++ ED KL E N+ + LK + ER LQ R
Sbjct: 1543 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1592
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
+ E+ R ++ L +ER ++ + L +K+LE D K +
Sbjct: 1593 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 179 LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
+L KL++ F E R + KENEK K L L Q ++ +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
R ++LE+ +L E ++S+L + + + ++ E + N ++V+
Sbjct: 1710 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 290 DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Q+ E+L ++ S LE + K+++SK ++++ + ++K K +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1824
Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR----------HERTKFRGHGSEASVSKH 388
LE Q+++Q E E E + L K + ER + +A
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 389 TARELSPQ-----------HKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
++L Q + R RE E+ R+V++ RR + S +
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1944
Query: 438 G---------VSTDSGTQETKKTEDRFVPGSSQSE 463
+ G++E T D G+ SE
Sbjct: 1945 PSRRSGGRRVIENADGSEEETDTRDADFNGTKASE 1979
Score = 63.9 bits (154), Expect = 8e-10
Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
+L++ ++EE++ ED + KE+ ++ EN +EL+ + +L + L++ +A +
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
+ ++ + L ++ ++I E+E LE EDR Q L +E +K+ L
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 960
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+ L E+E +KL E + KK+ +++ + D ++ L
Sbjct: 961 DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 1004
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
SKE RK + + + + E KN + NK + + E+E +LK + K + LE+
Sbjct: 1005 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 311 ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
+K++ +D + L +Q+ E+K+Q+ KK++EL+ +D
Sbjct: 1063 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 370 RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
++ + GH S+ S+ AR + + KR+ E AL E L + S+ +
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1171
Query: 426 FTNRRAAKASHMGVSTDSGTQETKKTE 452
RA + + V + +ET+ E
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHE 1198
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 89.7 bits (221), Expect = 1e-17
Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
+ + + DEL++ + QKAE+EL +L+ K Q E N + + AE E +R
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 917
Query: 71 RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
+R+ K +E+ E++ M+ +LEEEE+ ++L++E +++ ++M +LE+ EE +
Sbjct: 918 --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
R K L L KK+ E+ ++ KE + E+R+ +LA E E
Sbjct: 973 RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 185 KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
K K+LT S +SE + +KE+++ + +++L +KLE + + D +
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 235 LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
L+ + E+ + + L + +++ L ++++E + E+ RN+ + +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 288 VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
+DL +E+E LKT+++ + ++EL+ + + + L E+ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 334 -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
+ L QLE+ K + K + +E E+A L+ + + G + K
Sbjct: 1208 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1261
Query: 389 TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
E Q + + + E A LN++ + L N S N KA + S +
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 446 QETKKTED 453
+ + T++
Sbjct: 1322 SQLQDTQE 1329
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
+E+E T L +AE + + L V S SS L + + L Q EE ++ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1340
Query: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
+ +++ EE +L +L E+E Q + L S SK ++
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
K+ E+E L + +E ++ D+L+KT+ L EL+ L + ++R+ ++ EK+
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1457
Query: 208 EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
K + L ++ + K + R A E L + + L +KE +
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
++E+ +K + KN ++ + + L ++E++KTQ+ E LE+EL+ + L+
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1574
Query: 325 NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
N L Q + L A + + + + Q++L E E ED + + K G
Sbjct: 1575 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634
Query: 382 EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
+ + +A E Q ++ + + ++F E+ S ++ + + N + AK+
Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691
Score = 79.3 bits (194), Expect = 2e-14
Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
K R L +L++L L++ ++T Q K E E+ L+ + + S+ + +
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 64 EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
E+ Q V + + E+ KRA+ K+ LE+E +L EL+ + Q+ + +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
KLE ++ C+ + E + K+ +E+E + + E E +L K SL+S
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 182 EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+L E L+ T ++ L + E+E L +L +++E + + R + L
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
+ +++D S+ +E +++ + K++EN T+ +K E KNR Q+ D+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 287 KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
V DL+ Q + L+ + + F+ L E K + SK D +D +E + K LA
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 340 LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
LEE L+ K++ E N ++ E + +SSK
Sbjct: 1499 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1527
Score = 67.0 bits (162), Expect = 9e-11
Identities = 92/392 (23%), Positives = 169/392 (43%), Gaps = 50/392 (12%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
A +R K SL+R L+E EA + L+ KAE E L D+ V + E S
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 60 SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
++ ++E ++ ++E ++E++ ED KL E N+ + LK + ER LQ R
Sbjct: 1543 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1592
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
+ E+ R ++ L +ER ++ + L +K+LE D K +
Sbjct: 1593 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 179 LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
+L KL++ F E R + KENEK K L L Q ++ +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
R ++LE+ +L E ++S+L + + + ++ E + N ++V+
Sbjct: 1710 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 290 DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Q+ E+L ++ S LE + K+++SK ++++ + ++K K +
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1824
Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
LE Q+++Q E E E + L K +
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Score = 65.9 bits (159), Expect = 2e-10
Identities = 77/398 (19%), Positives = 168/398 (42%), Gaps = 60/398 (15%)
Query: 19 KLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
+L+ R L+ ++EE L++ EDEL +D ++ E + ++ + E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 67 ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE--------EEENLTRELKSEIERLQ 114
L++++ E + E+ ++ L K+KLE + ++ + + I++L+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 115 KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDK 174
K A+++ + ++ ++ + E K + ++L L+ + E + + D
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 175 TEQSLASELEKLKSLTLSFVSERKYLN------EKEKENEK--------LIKELTQKLEQ 220
++ LA EL S + E++ L E+E E E+ +++ TQ+ EQ
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 221 --------------NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
N+ + R L +E + S S + + + L+
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 266 QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNNDLQD 324
QVE E R K K+ Q+D K+K++ ++E + + + E E+ ++K L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 325 NYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
+E+ ++ A++ KLQ + + E+ E G +
Sbjct: 1896 ---AEEESQRINANRR---KLQRELDEATESNEAMGRE 1927
Score = 63.9 bits (154), Expect = 8e-10
Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
+L++ ++EE++ ED + KE+ ++ EN +EL+ + +L + L++ +A +
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
+ ++ + L ++ ++I E+E LE EDR Q L +E +K+ L
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 960
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+ L E+E +KL E + KK+ +++ + D ++ L
Sbjct: 961 DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 1004
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
SKE RK + + + + E KN + NK + + E+E +LK + K + LE+
Sbjct: 1005 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 311 ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
+K++ +D + L +Q+ E+K+Q+ KK++EL+ +D
Sbjct: 1063 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 370 RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
++ + GH S+ S+ AR + + KR+ E AL E L + S+ +
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1171
Query: 426 FTNRRAAKASHMGVSTDSGTQETKKTE 452
RA + + V + +ET+ E
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHE 1198
Score = 62.8 bits (151), Expect = 2e-09
Identities = 66/321 (20%), Positives = 141/321 (43%), Gaps = 26/321 (8%)
Query: 11 ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
A+ + L L+ L + D EEA K L+K + ++ D Q ++ A S + A +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 67 VLRQRVLRIEGKDEEIKRAEDLC---RLMKEKLEEEENLTRELKSEIE----------RL 113
++ +E +++ EDL R K+ E+E L EL S + RL
Sbjct: 1684 ENEKKAKSLEADLMQLQ--EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 114 QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD 173
+ R+A+LE E + + + + + +++S+EL R ++ ES+ +L+
Sbjct: 1742 EARIAQLE---EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 174 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
+ + L S+L +++ S + + E + +L +++ Q+ + + + +
Sbjct: 1799 RQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV-KDLN 292
L+ L++ED KE KG +KQ++ + E + N K+ ++L+
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 293 QEIEKLKTQIKHFESLEEELK 313
+ E + + +L+ +L+
Sbjct: 1916 EATESNEAMGREVNALKSKLR 1936
Score = 55.5 bits (132), Expect = 3e-07
Identities = 54/230 (23%), Positives = 107/230 (46%), Gaps = 18/230 (7%)
Query: 8 KETASSRHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
+E ASS R LQ RRL+ + + + L++ + + + D+V +A + E+
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 67 VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-ELKSEIERLQKRMAELEKLEE 125
R + E ++++R + ++ KL E E + + KS I L+ ++A+LE+ E
Sbjct: 1782 TERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 126 AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
+R K T+ SL ++ K+I ++E R ++ + ++ + + L +LE+
Sbjct: 1839 QEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
+ E + +N + KL +EL + E N+ M R+ S L
Sbjct: 1896 AEE-------ESQRINANRR---KLQRELDEATESNEAMGREVNALKSKL 1935
Score = 40.0 bits (92), Expect = 0.012
Identities = 31/144 (21%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKA-----EDELLDLQDKVIQA----E 55
T+ K ++ + L + + L +L E+E A K+ K+ E ++ L+++V Q +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 56 GSNSSMLAEIEVLRQRVLRIEGK-------DEEIKRAEDLCRLMKEKLEEEENLTRELKS 108
+ S+ + + L++ +L++E + E+ ++ + +K +LEE E ++ + +
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 109 EIERLQKRMAELEKLEEAFSRSKN 132
+LQ+ + E + EA R N
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVN 1929
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 89.7 bits (221), Expect = 1e-17
Identities = 109/488 (22%), Positives = 221/488 (45%), Gaps = 72/488 (14%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSN---------SSMLAEIEVLRQ 70
+ + + DEL++ + QKAE+EL +L+ K Q E N + + AE E +R
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR- 910
Query: 71 RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL--EEAFS 128
+R+ K +E+ E++ M+ +LEEEE+ ++L++E +++ ++M +LE+ EE +
Sbjct: 911 --VRLAAKKQEL---EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 129 RSKNDCTQLCLSLNEERNLTKKISSELEML----RVKVKELESSEDRLDKTEQSLASELE 184
R K L L KK+ E+ ++ KE + E+R+ +LA E E
Sbjct: 966 RQK-----LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 185 KLKSLTL------SFVSERKYLNEKEKENEKLIKELTQKLEQN----KKMNRDYTRNASN 234
K K+LT S +SE + +KE+++ + +++L +KLE + + D +
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 235 LERNDLRIEDGISSTLPSKE---SRRKGGLDYLKQVENETRNKSEN----EKNRNQEDNK 287
L+ + E+ + + L + +++ L ++++E + E+ RN+ + +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 288 VKDLNQEIEKLKTQIK---HFESLEEELKKMKSKNNDLQDNYLSEQNKN----------- 333
+DL +E+E LKT+++ + ++EL+ + + + L E+ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 334 -----KLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKH 388
+ L QLE+ K + K + +E E+A L+ + + G + K
Sbjct: 1201 HAQAVEELTEQLEQFK-RAKANLDKNKQTLEKENADLAGE-----LRVLGQAKQEVEHKK 1254
Query: 389 TARELSPQHKRERLRNREFA---LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGT 445
E Q + + + E A LN++ + L N S N KA + S +
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 446 QETKKTED 453
+ + T++
Sbjct: 1315 SQLQDTQE 1322
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/417 (21%), Positives = 179/417 (42%), Gaps = 29/417 (6%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
+E+E T L +AE + + L V S SS L + + L Q EE ++ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDV----ASLSSQLQDTQELLQ---------EETRQKLN 1333
Query: 88 LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNL 147
+ +++ EE +L +L E+E Q + L S SK ++
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 148 TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN 207
K+ E+E L + +E ++ D+L+KT+ L EL+ L + ++R+ ++ EK+
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD---DLVVDLDNQRQLVSNLEKKQ 1450
Query: 208 EKLIKELTQKLEQNKKMNRDYTR---NASNLERNDLRIEDGISSTLPSKESRRKGGLDYL 264
K + L ++ + K + R A E L + + L +KE +
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 265 KQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQD 324
++E+ +K + KN ++ + + L ++E++KTQ+ E LE+EL+ + L+
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDELQATEDAKLRLEV 1567
Query: 325 NY--LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS-SKGRHERTKFRGHGS 381
N L Q + L A + + + + Q++L E E ED + + K G
Sbjct: 1568 NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627
Query: 382 EASVSKHTA----RELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
+ + +A E Q ++ + + ++F E+ S ++ + + N + AK+
Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684
Score = 79.3 bits (194), Expect = 2e-14
Identities = 97/390 (24%), Positives = 182/390 (46%), Gaps = 34/390 (8%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLA 63
K R L +L++L L++ ++T Q K E E+ L+ + + S+ + +
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 64 EIEVLR-QRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE-NLTRELKSEIERLQKRMAELE 121
E+ Q V + + E+ KRA+ K+ LE+E +L EL+ + Q+ + +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
KLE ++ C+ + E + K+ +E+E + + E E +L K SL+S
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 182 EL----EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+L E L+ T ++ L + E+E L +L +++E + + R + L
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETR---------NKSENEKNRNQE--DN 286
+ +++D S+ +E +++ + K++EN T+ +K E KNR Q+ D+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKR----FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 287 KVKDLN---QEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSE----QNKNKLLASQ 339
V DL+ Q + L+ + + F+ L E K + SK D +D +E + K LA
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 340 LEEIKLQIKKQKELENGEVEGE-DAFLSSK 368
LEE L+ K++ E N ++ E + +SSK
Sbjct: 1492 LEE-ALEAKEELERTNKMLKAEMEDLVSSK 1520
Score = 67.0 bits (162), Expect = 9e-11
Identities = 92/392 (23%), Positives = 169/392 (43%), Gaps = 50/392 (12%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQ------KAEDELL-----DLQDKVIQAEGSNS 59
A +R K SL+R L+E EA + L+ KAE E L D+ V + E S
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 60 SMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER-LQKRMA 118
++ ++E ++ ++E ++E++ ED KL E N+ + LK + ER LQ R
Sbjct: 1536 ALETQMEEMK---TQLEELEDELQATED------AKLRLEVNM-QALKGQFERDLQARDE 1585
Query: 119 ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQS 178
+ E+ R ++ L +ER ++ + L +K+LE D K +
Sbjct: 1586 QNEEKRRQLQRQLHEYE---TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 179 LASELEKLKSLTLSFVSE-------RKYLNEKEKENEKLIKELTQKLEQNKK--MNRDYT 229
+L KL++ F E R + KENEK K L L Q ++ +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 230 RNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVK 289
R ++LE+ +L E ++S+L + + + ++ E + N ++V+
Sbjct: 1703 RKQADLEKEELAEE--LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 290 DLNQEIEKLKTQIKHFES-----------LEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
Q+ E+L ++ S LE + K+++SK ++++ + ++K K +
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG---AVKSKFKSTIA 1817
Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
LE Q+++Q E E E + L K +
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Score = 65.9 bits (159), Expect = 2e-10
Identities = 77/398 (19%), Positives = 168/398 (42%), Gaps = 60/398 (15%)
Query: 19 KLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
+L+ R L+ ++EE L++ EDEL +D ++ E + ++ + E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 67 ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE--------EEENLTRELKSEIERLQ 114
L++++ E + E+ ++ L K+KLE + ++ + + I++L+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 115 KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDK 174
K A+++ + ++ ++ + E K + ++L L+ + E + + D
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 175 TEQSLASELEKLKSLTLSFVSERKYLN------EKEKENEK--------LIKELTQKLEQ 220
++ LA EL S + E++ L E+E E E+ +++ TQ+ EQ
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 221 --------------NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
N+ + R L +E + S S + + + L+
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 266 QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNNDLQD 324
QVE E R K K+ Q+D K+K++ ++E + + + E E+ ++K L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 325 NYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
+E+ ++ A++ KLQ + + E+ E G +
Sbjct: 1889 ---AEEESQRINANRR---KLQRELDEATESNEAMGRE 1920
Score = 63.9 bits (154), Expect = 8e-10
Identities = 87/387 (22%), Positives = 172/387 (44%), Gaps = 45/387 (11%)
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
+L++ ++EE++ ED + KE+ ++ EN +EL+ + +L + L++ +A +
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
+ ++ + L ++ ++I E+E LE EDR Q L +E +K+ L
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEME------ARLEEEEDR----GQQLQAERKKMAQQML 953
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+ L E+E +KL E + KK+ +++ + D ++ L
Sbjct: 954 DL---EEQLEEEEAARQKLQLEKVTAEAKIKKL------------EDEILVMDDQNNKL- 997
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIE-KLKTQIKHFESLEE 310
SKE RK + + + + E KN + NK + + E+E +LK + K + LE+
Sbjct: 998 SKE--RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 311 ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFLSSKG 369
+K++ +D + L +Q+ E+K+Q+ KK++EL+ +D
Sbjct: 1056 LKRKLEGDASDFHEQIAD-------LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 370 RHERTK-FRGHGSEASV---SKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
++ + GH S+ S+ AR + + KR+ E AL E L + S+ +
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE-ALKTE---LEDTLDSTAT 1164
Query: 426 FTNRRAAKASHMGVSTDSGTQETKKTE 452
RA + + V + +ET+ E
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHE 1191
Score = 62.8 bits (151), Expect = 2e-09
Identities = 66/321 (20%), Positives = 141/321 (43%), Gaps = 26/321 (8%)
Query: 11 ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
A+ + L L+ L + D EEA K L+K + ++ D Q ++ A S + A +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 67 VLRQRVLRIEGKDEEIKRAEDLC---RLMKEKLEEEENLTRELKSEIE----------RL 113
++ +E +++ EDL R K+ E+E L EL S + RL
Sbjct: 1677 ENEKKAKSLEADLMQLQ--EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 114 QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD 173
+ R+A+LE E + + + + + +++S+EL R ++ ES+ +L+
Sbjct: 1735 EARIAQLE---EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 174 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
+ + L S+L +++ S + + E + +L +++ Q+ + + + +
Sbjct: 1792 RQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV-KDLN 292
L+ L++ED KE KG +KQ++ + E + N K+ ++L+
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNA-RVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 293 QEIEKLKTQIKHFESLEEELK 313
+ E + + +L+ +L+
Sbjct: 1909 EATESNEAMGREVNALKSKLR 1929
Score = 55.5 bits (132), Expect = 3e-07
Identities = 54/230 (23%), Positives = 107/230 (46%), Gaps = 18/230 (7%)
Query: 8 KETASSRHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
+E ASS R LQ RRL+ + + + L++ + + + D+V +A + E+
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 67 VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-ELKSEIERLQKRMAELEKLEE 125
R + E ++++R + ++ KL E E + + KS I L+ ++A+LE+ E
Sbjct: 1775 TERSTAQKNESARQQLERQN---KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 126 AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
+R K T+ SL ++ K+I ++E R ++ + ++ + + L +LE+
Sbjct: 1832 QEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL 235
+ E + +N + KL +EL + E N+ M R+ S L
Sbjct: 1889 AEE-------ESQRINANRR---KLQRELDEATESNEAMGREVNALKSKL 1928
Score = 40.0 bits (92), Expect = 0.012
Identities = 31/144 (21%), Positives = 71/144 (49%), Gaps = 16/144 (11%)
Query: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKA-----EDELLDLQDKVIQA----E 55
T+ K ++ + L + + L +L E+E A K+ K+ E ++ L+++V Q +
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 56 GSNSSMLAEIEVLRQRVLRIEGK-------DEEIKRAEDLCRLMKEKLEEEENLTRELKS 108
+ S+ + + L++ +L++E + E+ ++ + +K +LEE E ++ + +
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 109 EIERLQKRMAELEKLEEAFSRSKN 132
+LQ+ + E + EA R N
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVN 1922
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 85.1 bits (209), Expect = 3e-16
Identities = 70/351 (19%), Positives = 161/351 (45%), Gaps = 47/351 (13%)
Query: 11 ASSRHLRFKLQSLSRRLD---ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
A + HL +LQS+S +L E E L + ++E + Q++ IQ E
Sbjct: 253 AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQERE---------EK 303
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
++++ +I ++E+++R E++ +EK+ +E + E + +I L+++M E EK+ E
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE-- 361
Query: 128 SRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187
K + + + K+ + E +R + +++ E+ + + E+ + + EK+
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 188 SLTLSFVSERKYL---NEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
+ + + EK +E EK I+E +K+ + ++M
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM-------------------- 461
Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQED---NKVKDLNQEIEKLKTQ 301
+E K G K E E + + + EK R QE+ + K + ++ EK++ Q
Sbjct: 462 -------MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Query: 302 IKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE 352
+ + EE++ + + K + ++ ++ K + ++ E ++++++Q+E
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Score = 67.0 bits (162), Expect = 9e-11
Identities = 78/350 (22%), Positives = 161/350 (46%), Gaps = 37/350 (10%)
Query: 65 IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLE 124
+E+ R + E K++ K E L + EK E + N+ +ELK ++ER + + + +
Sbjct: 195 LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-KELKRKLERAKLLLPQQQLQA 253
Query: 125 EA--FSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKE-LESSEDRLDKTEQSLAS 181
EA + + + EE L +++ + E + +E ++ E+++ + E+ +
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 182 ELEKLKSLT-LSFVSERKYLNEKEK--ENEKLIKELTQKLEQNKKMNRDYTRNASNLERN 238
+ EK++ + + E K ++E E E+ I+EL +K+ + +K+ E+
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR----------EQE 363
Query: 239 DLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKL 298
+ R E+ + +E R++ K E + + + EK R QE+ + ++ EK+
Sbjct: 364 EKRQEE---EKIREQEKRQE---QEAKMWRQEEKIREQEEKIREQEEM----MQEQEEKM 413
Query: 299 KTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELEN--G 356
Q + EEE+++ + K Q+ + EQ K + Q E+I+ Q + +E E G
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMR-RQEEKIREQEKK--IREQEEKIREQEEMMQEQEEKMG 470
Query: 357 EVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNRE 406
E EG+ +K + + K R + + RE + E++R +E
Sbjct: 471 EQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE-----QEEKIREQE 515
Score = 55.1 bits (131), Expect = 4e-07
Identities = 35/198 (17%), Positives = 104/198 (52%), Gaps = 15/198 (7%)
Query: 25 RRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKR 84
R+ +++ E + +++ E+ + + ++K+ + E M + E ++++ ++ ++E+I+
Sbjct: 387 RQEEKIREQEEKIREQEEMMQEQEEKMGEQE---EKMWEQEEEMQEQEEKMRRQEEKIRE 443
Query: 85 AEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE-KLEEAFSRSKNDCTQLCLSLNE 143
E R +EK+ E+E + +E + ++ + +M E E K++E + + ++ +
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Query: 144 ERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEK 203
R +KI + EM++ + +++ E+++ + E+ + + EK++ EK
Sbjct: 504 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR-----------QEEK 552
Query: 204 EKENEKLIKELTQKLEQN 221
+E E +++ +K++++
Sbjct: 553 MREQEVRLRQQEEKMQEH 570
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 85.1 bits (209), Expect = 3e-16
Identities = 107/497 (21%), Positives = 207/497 (41%), Gaps = 99/497 (19%)
Query: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVL--------RIEGKDEEIKRAE 86
+ LQ ++ELL +++K + EG L E+E Q++L +++ + E AE
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGE----LEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 87 DLCRLMKEKLEEEENLTRELKSEIERLQKR-----------MAELEKLEEAFSRSKNDCT 135
++ + K +E E + +L+S +E ++R A ++ LEE +
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 136 QLCLSLNEERNLTKKISSELEMLRVK----VKELESSEDRLDKTEQSLASELEKLKSLTL 191
+L L KK+ E+ +L + +KE + EDR+ + LA E EK K+L
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA- 1026
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS--- 248
+ + E +I +L ++L++ +K ++ + L+ ++D I+
Sbjct: 1027 ----------KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA 1076
Query: 249 -------TLPSKESRRKGGL-----------DYLKQVEN------ETRNKSENEK-NRNQ 283
L KE +G L + LK V E + E+EK +RN+
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 284 EDNKVKDLNQEIEKLKTQIKHF----------------------ESLEEELKKMKSKNND 321
+ + +DL++E+E LKT+++ ++LEEE K +++ D
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 322 LQDNYLSEQNKNKLLASQLEEIKLQIKKQK---ELENGEVEGEDAFL---SSKGRHERTK 375
++ + + + Q + K ++K K E +N E+ E L ++ H+R K
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK 1256
Query: 376 FRGHGSE--ASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAK 433
E A VS+ + K +L+N L+N + L + F A+
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNE---LDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 434 ASHMGVSTDSGTQETKK 450
S + + + +ET++
Sbjct: 1314 ESQLQDTQELLQEETRQ 1330
Score = 84.7 bits (208), Expect = 4e-16
Identities = 94/417 (22%), Positives = 192/417 (46%), Gaps = 83/417 (19%)
Query: 14 RHLRFKLQSLSRRLDELEEATKNLQ----KAEDELLDLQDKVIQAEGSNSSMLAEIEVLR 69
+ ++ +Q L +LDE E A + LQ AE ++ ++++++ E NS + E +++
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 70 QRVLRIEGK-DEEIKRAEDLCRL----------MKEKLEEEENLTRELKS-------EIE 111
R+ + EE ++A++L ++ ++E+L++EE +EL+ E
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 112 RLQKRMAEL---------------EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELE 156
LQ ++AEL E+L+ A +R ++ L N + +++ +++
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET----LHKNNALKVVRELQAQIA 1121
Query: 157 MLRVKVKELESSEDRLDKTEQSLASELEKLKSL---TLSF--------------VSERKY 199
L+ + ++S ++ +K ++ L+ ELE LK+ TL V+E K
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 200 LNEKEKENEK------------LIKELTQKLEQNKKMNRDYTRNASNLE--RNDLRIEDG 245
E+E +N + ++EL+++LEQ K+ + +N LE +L E
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
+ + ++ ++ LD QV+ SE ++ R + K L E++ + T ++
Sbjct: 1242 VLQQVKAESEHKRKKLD--AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 306 E----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS----QLEEIKLQIKKQKELE 354
E ++ ++S+ D Q+ L E+ + KL S QLEE K +++Q+E E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQE-LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Score = 76.3 bits (186), Expect = 1e-13
Identities = 83/393 (21%), Positives = 166/393 (42%), Gaps = 32/393 (8%)
Query: 9 ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV- 67
E A + ++F + S +L++ + LQ+ + L+L ++ Q E +S+ + E
Sbjct: 1297 EEAEKKGIKFAKDAASLE-SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 68 ------LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEE-EENLTRELKSEIERLQKRMAEL 120
L ++VL ++ + + K+ D E LEE ++ L ++ ++ +RL+++
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
+KLE+ +R + + L + L+ +R + + + + + E +S R +
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
+E + ++ LS + E ++E E+ K+L +E D +N LE++
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSEN---EKNRNQEDNKVKDLNQEIEK 297
+E + E D L+ E+ N K + + D + +D Q EK
Sbjct: 1536 ALEQQVEEMRTQLEELE----DELQATEDAKLRLEVNMQAMKAQFERDLQTRD-EQNEEK 1590
Query: 298 LKTQIKHFESLEEEL--------------KKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
+ IK LE EL KKM+ DL+ + + QL ++
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 344 KLQIKK-QKELENGEVEGEDAFLSSKGRHERTK 375
+ Q+K Q+ELE ++ F SK ++ K
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Score = 69.7 bits (169), Expect = 1e-11
Identities = 69/295 (23%), Positives = 133/295 (45%), Gaps = 35/295 (11%)
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
+L++ ++EE++ ++ +KEK +++ E+E ++++ +L + + +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEK-------QTKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
T+L E R ELE + + +LES + ++ Q L +E +K+++
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEI---LHDLESRVEEEEERNQILQNEKKKMQA--- 950
Query: 192 SFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+ L+E+E +KL E + KKM E L +ED S +
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM-----------EEEILLLEDQNSKFIK 999
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE 311
K+ + Q+ E K RN+++ + DL E+LK + K + LE+
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE---ERLKKEEKTRQELEKA 1056
Query: 312 LKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI-KKQKELENGEVEGEDAFL 365
+K+ + DLQD L +Q++E+KLQ+ KK++EL+ G+D L
Sbjct: 1057 KRKLDGETTDLQDQIAE-------LQAQIDELKLQLAKKEEELQGALARGDDETL 1104
Score = 67.0 bits (162), Expect = 9e-11
Identities = 83/361 (22%), Positives = 159/361 (44%), Gaps = 42/361 (11%)
Query: 12 SSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQR 71
+ L+ +L L+ LD + NL+K + + D+++ E S S+ AE R R
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF----DQLLAEEKSISARYAEE---RDR 1473
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRE---LKSEIERLQ-------KRMAELE 121
E +++E K A L R ++E LE +E R+ L++++E L K + ELE
Sbjct: 1474 A-EAEAREKETK-ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
K + A + + L +E T+ LE+ +++ + + ++ Q+
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV------NMQAMKAQFERDLQTRDE 1585
Query: 182 ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
+ E+ K L + V E E E E+E+ K+ + KKM D + +E + +
Sbjct: 1586 QNEEKKRLLIKQVREL----EAELEDER--KQRALAVASKKKMEIDLKDLEAQIEAAN-K 1638
Query: 242 IEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
D + L +++ K DY +++E ++ E + + K+K L EI +L+ +
Sbjct: 1639 ARDEVIKQLRKLQAQMK---DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 302 I-------KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
+ +H E +EL + + + L E+ + + +QLEE + + EL
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Query: 355 N 355
N
Sbjct: 1756 N 1756
Score = 58.9 bits (141), Expect = 2e-08
Identities = 80/401 (19%), Positives = 170/401 (42%), Gaps = 72/401 (17%)
Query: 19 KLQSLSRRLDE-LEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE----------- 66
+L+ R L++ +EE L++ EDEL +D ++ E + +M A+ E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 67 ----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLE----------EEENLTR-ELKSEIE 111
+L ++V +E + E+ ++ L K+K+E E N R E+ ++
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 112 RLQKRMAELEK-LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
+LQ +M + ++ LEEA R+ D ++ E K + +E+ L+ ++ E +
Sbjct: 1649 KLQAQMKDYQRELEEA--RASRD--EIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704
Query: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLN----------EKEKENEKLIKELTQKL-- 218
++ LA E+ S + + E++ L E+E+ N +L+ + +K
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764
Query: 219 -----------EQNKKMNRDYTRNASNLERNDLR-----IEDGISSTLPSKESRRKGGLD 262
E++ D R + +L+ +E + S + S + +
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824
Query: 263 YLK-QVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF-ESLEEELKKMKSKNN 320
L+ Q+E E + ++ K + + K+K++ ++E + + E +E+ +MK
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
L++ +E+ + AS+ K Q+EL++ E
Sbjct: 1885 QLEE---AEEEATRANASRR-------KLQRELDDATEANE 1915
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/327 (18%), Positives = 141/327 (43%), Gaps = 48/327 (14%)
Query: 11 ASSRHLRFKLQSLSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE 66
AS + + L+ L +++ +E K L+K + ++ D Q ++ +A S + A+ +
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 67 VLRQRVLRIEGK----DEEIKRAEDLCRLMKEK------------------LEEEENLTR 104
+++ +E + EE+ +E R +++ L+E+ L
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736
Query: 105 ELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEER-------NLTKKISSELEM 157
+ E L++ + +E L + F ++ L L ER N +++ + +
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 158 LRVKVKELESS-EDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQ 216
L+ K++ELE + + + T +L +++ +L+ ER N+ + EK +KE+
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 217 KLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE 276
++E ++ Y +E+ + R++ ++E + N +R K +
Sbjct: 1857 QVEDERRHADQY---KEQMEKANARMKQLKRQLEEAEEEATRA---------NASRRKLQ 1904
Query: 277 NEKNRNQEDNKVKDLNQEIEKLKTQIK 303
E + E N + L++E+ LK +++
Sbjct: 1905 RELDDATEAN--EGLSREVSTLKNRLR 1929
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 83.2 bits (204), Expect = 1e-15
Identities = 103/436 (23%), Positives = 192/436 (44%), Gaps = 40/436 (9%)
Query: 11 ASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLD----LQDKVIQAEGSNSSMLAEIE 66
A LR KLQ L +LEEA Q+ E L L+ ++ +A+ + + E +
Sbjct: 758 AVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQ 817
Query: 67 VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEA 126
L R L EGK E+ R K +LEE++ L L ++RL K ELEK+ E
Sbjct: 818 TLN-RALEEEGKQREVLRRG------KAELEEQKRL---LDRTVDRLNK---ELEKIGED 864
Query: 127 FSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
SK QL L + + +K E+ + + K+ S ++ L E+++L
Sbjct: 865 ---SKQALQQLQAQLEDYK---EKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRL 918
Query: 187 KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIE--- 243
+ + +ER ++ + ++ L Q+ E K+ D R LE R+E
Sbjct: 919 RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL 978
Query: 244 DGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIK 303
D +T+ R G D + Q+ E E ++ E +K+ L ++ + LKT++
Sbjct: 979 DEEKNTVELLTDRVNRGRDQVDQLRTELMQ--ERSARQDLECDKIS-LERQNKDLKTRLA 1035
Query: 304 HFESLEE---ELKKMKSKNNDLQDNYLSE-------QNKNKLLASQLEEIKLQIKKQKEL 353
E ++ L +++S+N LQ+ +E Q+ N+ L +++E+ +QI+ +++
Sbjct: 1036 SSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQH 1095
Query: 354 ENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHK-RERLRNREFALNNE 412
N + + + + R + K RE+ QH+ E+L+ R +L +
Sbjct: 1096 VNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155
Query: 413 NYSLSNRQVSSPSFTN 428
++ ++R + + N
Sbjct: 1156 SWRKASRSAAESALKN 1171
Score = 59.7 bits (143), Expect = 1e-08
Identities = 73/339 (21%), Positives = 141/339 (41%), Gaps = 20/339 (5%)
Query: 20 LQSLSRRLDELEE-ATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
LQ L +L++ +E A + + A+ + D + + G S + EI+ LRQ + + +
Sbjct: 869 LQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAE 928
Query: 79 DEEIKRAEDLCRLMKEKLEEE-ENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
+ + ++L + LE+E EN R +L+ ++ +LE KN L
Sbjct: 929 RDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELL 988
Query: 138 CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
+N R+ ++ +EL R ++LE + L++ + L + L + F
Sbjct: 989 TDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSE----GFQKPS 1044
Query: 198 KYLNEKEKENEKLIKELTQKLEQNKKM----NRDYTRNASNLERNDLRIEDGISSTLPSK 253
L++ E +N+ L++E Q E+ K + NR R L ++IED K
Sbjct: 1045 ASLSQLESQNQ-LLQERLQAEEREKTVLQSTNRKLERKVKEL---SIQIEDERQHVNDQK 1100
Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
+ +QV+ + R + +V++ ++ E+L+ +IK E
Sbjct: 1101 DQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKA 1160
Query: 314 KMKSKNNDLQDNYLSEQNK------NKLLASQLEEIKLQ 346
+ + L++ LS + +AS L E LQ
Sbjct: 1161 SRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQ 1199
Score = 55.8 bits (133), Expect = 2e-07
Identities = 80/397 (20%), Positives = 171/397 (43%), Gaps = 35/397 (8%)
Query: 75 IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDC 134
+ G+ E ++ E+L R + E++++ + L +L+++ E +L+E R K +
Sbjct: 358 VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA 417
Query: 135 TQ-------LCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187
Q + L++ +L + +++ L+ K+K ++ E + + L E L+
Sbjct: 418 QQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLE 477
Query: 188 SLT--LSFVSERKYLNEKEKENEK--LIKELTQKLEQNKKMNRDYTRNASNLERN--DLR 241
+ V E+ L E+E K L +E+ + ++ + + + Y R+ L R+ D
Sbjct: 478 EVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDAT 537
Query: 242 IEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQ 301
+ + K S GL + +E ++ +N+ED ++ QE+ +L+ +
Sbjct: 538 QDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED--LRATKQELLQLRME 595
Query: 302 IKHFESLEEEL-KKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
E +EEEL +K++ +L+ S + Q+E +K ++ + +E E E++
Sbjct: 596 ---KEEMEEELGEKIEVLQRELEQARASAGD-----TRQVEVLKKELLRTQE-ELKELQA 646
Query: 361 EDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSN-- 418
E GRH + + V REL Q+ + + ++ + E S +
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
Query: 419 RQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRF 455
+ + RRAA ++ +ET++ D F
Sbjct: 707 AEAEATVLGQRRAA--------VETTLRETQEENDEF 735
Score = 48.5 bits (114), Expect = 3e-05
Identities = 145/723 (20%), Positives = 287/723 (39%), Gaps = 78/723 (10%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELL-DLQDK-----VIQAEGSNSSMLAEIEVLRQRVLR 74
+ ++ R E+E + Q+ ++L +QD V++AE S L +R
Sbjct: 506 EEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSAL-----VRGLQRE 560
Query: 75 IEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-LEKLEEAFSRSKND 133
+E EE + + + KE L + +L+ E E +++ + E +E L+ +++
Sbjct: 561 LEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQAR-- 618
Query: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
S + R + + + EL + ++KEL++ + + ELEK ++
Sbjct: 619 -----ASAGDTRQV-EVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672
Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
+ L E+ + +K +++L Q E+ K A+ L + +E + T
Sbjct: 673 ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732
Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
+ R+ L L+Q ETR + + + +++D Q +E K Q LEE L
Sbjct: 733 DEFRRRILG-LEQQLKETRGLVDGGE---AVEARLRDKLQRLEAEKQQ------LEEAL- 781
Query: 314 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI----KKQKELENG-EVEGEDAFLSSK 368
N Q+ S + L ++LEE + + ++Q+ L E EG+ + +
Sbjct: 782 ------NASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRR 835
Query: 369 GRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY-SLSNRQVSSPSFT 427
G+ E + + + E + ++ L+ + L E+Y + R+V+
Sbjct: 836 GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL--EDYKEKARREVAD---A 890
Query: 428 NRRAAKASHMGVSTDSGTQETKKTEDRFVPG--SSQSEGKKSREQPSVLSRYPPAAQEHS 485
R+A + T G + R +SQ+E +R +L++ ++ +
Sbjct: 891 QRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 950
Query: 486 KAWKGTSKPGTESGLKGKVEKTTR--TFSDTTHGSVP--SDPLGRADKASDTSSETVFGK 541
+ K S+ LKG EK +R T D +V +D + R D + +
Sbjct: 951 EN-KKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQE 1009
Query: 542 RGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPV 601
R + Q + + L +R +SSEG K + + LE+ N +
Sbjct: 1010 R-----SARQDLECDKISLERQNKDL-KTRLASSEGFQKPSASLSQLESQNQ-------L 1056
Query: 602 LSKYPYSCRSQENILQGFSTSHK-EGVNQPAAVVMEDSSPHE-------ALRCRVIKSSG 653
L + + ++ +LQ ST+ K E + ++ +ED H +LR + +K
Sbjct: 1057 LQERLQAEEREKTVLQ--STNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114
Query: 654 REKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGM 713
E + + LD + V + + + S EK R A R++ K+ G+
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGL 1174
Query: 714 ENE 716
++
Sbjct: 1175 SSD 1177
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 83.2 bits (204), Expect = 1e-15
Identities = 112/478 (23%), Positives = 207/478 (43%), Gaps = 72/478 (15%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEAT----KNLQKAEDELLDLQDKVIQAE-------- 55
KE +S LR KL ++ +LE + + + E+EL ++++V+Q E
Sbjct: 1305 KEEVAS--LRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEP 1362
Query: 56 ---GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER 112
S+ I+V +++ ++ + ++R E+LE E RE + E++R
Sbjct: 1363 GLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422
Query: 113 LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
LQ+R+A LE+ EEA +R K TQ + + + + E +LR+ +LE + R
Sbjct: 1423 LQQRLAALEQ-EEAEAREKVTHTQKVVLQQDPQQ-----AREHALLRL---QLEEEQHRR 1473
Query: 173 DKTEQSLASELEKLKSLTLSFVSERKYLNE----KEKENEKLIKELTQKLEQNKKMNRDY 228
E L + KL +L + V E+ L+E ++ + E+ I+ L LE+ + R+
Sbjct: 1474 QLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKREL 1533
Query: 229 TRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV 288
S LE S L S+ LD+L++ EN K + + N
Sbjct: 1534 DVEVSRLEAR--------LSELEFHNSKSSKELDFLRE---------ENHKLQLERQN-- 1574
Query: 289 KDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
L E +L+++I + +L+ M + D+ + ++ L +L+++K ++
Sbjct: 1575 --LQLETRRLQSEINMAATETRDLRNM-----TVADSGTNHDSRLWSLERELDDLK-RLS 1626
Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE-------- 400
K K+LE E++ ++ K R S + T RELSP+
Sbjct: 1627 KDKDLEIDELQKRLGSVAVKREQRENHLR--RSIVVIHPDTGRELSPEEAHRAGLIDWNM 1684
Query: 401 --RLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFV 456
+LR++E + E S+ S +R++ K + + SG + T DR+V
Sbjct: 1685 FVKLRSQE--CDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSG-RLTPAQYDRYV 1739
Score = 50.4 bits (119), Expect = 9e-06
Identities = 57/275 (20%), Positives = 119/275 (43%), Gaps = 53/275 (19%)
Query: 92 MKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKI 151
M+ KL+ ++NL E+ S + +QK A ++ ++A + + +L L+ E + +
Sbjct: 763 METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHV 822
Query: 152 SSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLI 211
S K L+S ++ + E +LA++ ++ + +N + +N +
Sbjct: 823 S--------KRARLQSPATKVKEEEAALAAKFTEVYA-----------INRQRLQNLEFA 863
Query: 212 KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENET 271
L ++ + + + RN R + G+ + K+++ ET
Sbjct: 864 LNLLRQQPEVEVTHETLQRN---------RPDSGVEEAWKIR-----------KELDEET 903
Query: 272 RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK------MKSKNNDLQDN 325
+ R Q +N+VK +EI L+ Q + +E+ K ++ LQ
Sbjct: 904 -------ERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRT 956
Query: 326 YLSEQNKNKLLASQLEEIKLQIKK-QKELENGEVE 359
EQ+KN+LL +LE ++LQ++ ++E +G E
Sbjct: 957 LAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
Score = 46.6 bits (109), Expect = 1e-04
Identities = 78/394 (19%), Positives = 171/394 (43%), Gaps = 54/394 (13%)
Query: 29 ELEEATKNLQKAEDELLDLQDKV--IQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAE 86
EL+E T+ ++ E+E+ Q+++ ++ +G S V+R+ VL+ + D + E
Sbjct: 898 ELDEETERRRQLENEVKSTQEEIWTLRNQGPQES------VVRKEVLK-KVPDPVL---E 947
Query: 87 DLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERN 146
+ + ++ L EE++ + L+ E+E LQ ++ LE +E + + L + +R
Sbjct: 948 ESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALE--QETRDGGQEYVVKEVLRIEPDRA 1005
Query: 147 LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE 206
++ E L ++ + E + +Q +A+ E EK +
Sbjct: 1006 QADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAE-----------------EKSRA 1048
Query: 207 NEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL---RIEDGIS------STLPSKESRR 257
EK+ ++ KL+ + ++ +Y + + +R D + E+ +S L + +
Sbjct: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
Query: 258 KGGL---DYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK 314
+G + + LK ++ + ++ R ED K + EK + ++ +LEEE K
Sbjct: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTEL-LRKIWALEEENAK 1167
Query: 315 MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
+ +Q+ + S++ ++L++ +Q+ G E+ S + E
Sbjct: 1168 VV-----VQEKVREIVRPDPKAESEVANLRLELVEQERKYRG---AEEQLRSYQSELEAL 1219
Query: 375 KFRGHGSEA-SVSKHTAR-ELSPQHKRERLRNRE 406
+ RG E V+K + + P+ ++E R RE
Sbjct: 1220 RRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLRE 1253
Score = 43.1 bits (100), Expect = 0.001
Identities = 76/356 (21%), Positives = 134/356 (37%), Gaps = 47/356 (13%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE- 66
+E A + LR L+ R + + E K+L+ +ELL ++ + ++ + + +
Sbjct: 521 QEKAITGILRPPLEQ-GRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
Query: 67 -----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
+LR RV K E + + DL + EK++ L + L+ E L L
Sbjct: 580 SGTTPLLRTRVEDTNRKYEHLLQLLDLAQ---EKVDVANRLEKSLQQSWELLATHENHLN 636
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLAS 181
+ + S+ + S+ + L EL++ + L + EQ+L +
Sbjct: 637 QDDTVPESSR------------------VLDSKGQELAAMACELQAQKSLLGEVEQNLQA 678
Query: 182 ELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLR 241
+ +L F L +E E KL + L Q + ++A + R
Sbjct: 679 AKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNN-LRQQVERRAQSLQSAKAAYEHFHR 737
Query: 242 IEDGISSTLPSKESRRKGGLDYLKQVENETRNKS-----------ENEK---NRNQEDNK 287
D + L S S D L Q+E + +N+ E +K N Q
Sbjct: 738 GHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA 797
Query: 288 VKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
VKD E EKL++ + LE SK LQ + + LA++ E+
Sbjct: 798 VKDYELEAEKLRSLL----DLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV 849
Score = 42.7 bits (99), Expect = 0.002
Identities = 93/423 (21%), Positives = 172/423 (40%), Gaps = 54/423 (12%)
Query: 14 RHLRFKLQSLSRRLDELEEA--TKNLQKAED----ELLDLQDKVIQAEGSNSSMLAEIEV 67
R +R K R L + E T+N A D +LL DKV A + A +
Sbjct: 471 RSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKV--ASDLDRQEKAITGI 528
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE-----LEK 122
LR + + + +RA+DL + E L E TR +Q L
Sbjct: 529 LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT 588
Query: 123 LEEAFSRSKNDCTQLCLSLNEER-----NLTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
E +R QL L L +E+ L K + E+L L + +D + ++ +
Sbjct: 589 RVEDTNRKYEHLLQL-LDLAQEKVDVANRLEKSLQQSWELLATHENHL-NQDDTVPESSR 646
Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
L S+ ++L ++ +++ L E E +N + K+ + L + + +LER
Sbjct: 647 VLDSKGQELAAMACELQAQKSLLGEVE-QNLQAAKQCSSTLASR------FQEHCPDLER 699
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRN----KSENEKNRNQEDNKVKDLNQ 293
+ + K +R L +QVE ++ K+ E D+ ++ L
Sbjct: 700 QEAEVH---------KLGQRFNNLR--QQVERRAQSLQSAKAAYEHFHRGHDHVLQFL-- 746
Query: 294 EIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ------LEEIKLQI 347
+ + + +SL + K+K++ N L + EQ K+ A+ +++ +L+
Sbjct: 747 -VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEA 805
Query: 348 KKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREF 407
+K + L + E G + +S + R + + EA+++ + R+RL+N EF
Sbjct: 806 EKLRSLLDLE-NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAIN--RQRLQNLEF 862
Query: 408 ALN 410
ALN
Sbjct: 863 ALN 865
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 82.0 bits (201), Expect = 3e-15
Identities = 92/390 (23%), Positives = 179/390 (45%), Gaps = 37/390 (9%)
Query: 14 RHLRFKLQSLSRRLD-ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIE------ 66
+ +R L+ R+L+ +L+ +++ E++ L L++K+ + E + ++IE
Sbjct: 1044 KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLA 1103
Query: 67 -----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKR----- 116
L++ RIE +EE++ AE R EKL + L+REL+ ERL++
Sbjct: 1104 LQLQKKLKENQARIEELEEELE-AERTARAKVEKLRSD--LSRELEEISERLEEAGGATS 1160
Query: 117 -MAELEKLEEA-FSRSKNDCTQLCLSLNEERN-LTKKISSELEMLRVKVKELESSEDRLD 173
E+ K EA F + + D + L L KK + + L ++ L+ + +L+
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 174 KTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
K + EL+ + S + + L + + E E KLE+ ++ D+T
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT---- 1276
Query: 234 NLERNDLRIEDG-ISSTLPSKES----RRKGGLDYLKQVENETRNKSENEKNRNQEDNKV 288
+R L+ E+G ++ L KE+ +G L Y +Q+E+ R E K +N + +
Sbjct: 1277 -TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL 1335
Query: 289 KDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQI 347
+ + + L+ Q + + EL+++ SK N + ++ + + +LEE K ++
Sbjct: 1336 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1395
Query: 348 KKQKELENGEVEGEDAFLSSKGRHERTKFR 377
++ + VE +A SS E+TK R
Sbjct: 1396 AQRLQDAEEAVEAVNAKCSSL---EKTKHR 1422
Score = 70.5 bits (171), Expect = 8e-12
Identities = 72/284 (25%), Positives = 138/284 (48%), Gaps = 32/284 (11%)
Query: 147 LTKKISSELEMLRVK-----VKE-LESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL 200
L K +E EM +K +KE LE SE R + E+ + S L++ L L +E+ L
Sbjct: 841 LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 201 NEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGG 260
N+ E+ ++LIK Q + K+MN ER L E+ +++ L +K+ + +
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMN----------ER--LEDEEEMNAELTAKKRKLEDE 948
Query: 261 LDYLKQ-VENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKN 319
LK+ +++ ++ EK ++ +NKVK+L +E+ L I L +E K ++ +
Sbjct: 949 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII---AKLTKEKKALQEAH 1005
Query: 320 NDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGH 379
D+ E++K + L + K+++++Q + G +E E R +R K G
Sbjct: 1006 QQALDDLQVEEDK----VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKR-KLEG- 1059
Query: 380 GSEASVSKHTARELSPQ--HKRERLRNREFALNNENYSLSNRQV 421
+ +++ + +L E+L+ +EF +N +N + + QV
Sbjct: 1060 --DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQV 1101
Score = 68.9 bits (167), Expect = 2e-11
Identities = 91/412 (22%), Positives = 184/412 (44%), Gaps = 45/412 (10%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
+E + L+K+E +L++K++ S+L E L+ L+++ + + + AE+
Sbjct: 856 EEFGRIKETLEKSEARRKELEEKMV-------SLLQEKNDLQ---LQVQAEQDNLNDAEE 905
Query: 88 LC-RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERN 146
C +L+K K++ E + +E+ +E ++ AEL + + +++C++L +++
Sbjct: 906 RCDQLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKR---KLEDECSELKKDIDDLEL 961
Query: 147 LTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL-----KSLTLSFVSERKY-- 199
K+ E KVK L LD+ L E + L ++L V E K
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 200 LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKG 259
L++ + + E+ + +L LEQ KK+ D LER ++E + T S
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLEQEKKVRMD-------LERAKRKLEGDLKLTQESIMDLEND 1074
Query: 260 GLDYLKQVENETRNK--SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKS 317
L Q+E + + K N++N ED +V L + +KLK E LEEEL+ ++
Sbjct: 1075 KL----QLEEKLKKKEFDINQQNSKIEDEQVLALQLQ-KKLKENQARIEELEEELEAERT 1129
Query: 318 KNNDLQDNYLSEQNKNKLLASQLEE--------IKLQIKKQKELENGEVEGEDAFLSSKG 369
++ + + ++ +LEE I++ K++ E + + E+A L +
Sbjct: 1130 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189
Query: 370 RHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQV 421
+ + S A + + + K E+ ++ EF L ++ + + Q+
Sbjct: 1190 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS-EFKLELDDVTSNMEQI 1240
Score = 63.2 bits (152), Expect = 1e-09
Identities = 115/562 (20%), Positives = 229/562 (40%), Gaps = 90/562 (16%)
Query: 17 RFKLQSLSRRLDELEEATKNLQKAEDELL-DLQDK---VIQAEGSNSSMLAEIEVLRQRV 72
R KL+ R L++ LQ EL L++K + Q S ++E L+ R
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK-RQ 1320
Query: 73 LRIEGKDEE-----IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA--------- 118
L EGK + ++ A C L++E+ EEE EL+ + + +A
Sbjct: 1321 LEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1380
Query: 119 ------ELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK----ISSELEMLRVKVKELESS 168
ELE+ ++ ++ D + ++N + + +K + +E+E L V V+ ++
Sbjct: 1381 AIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
Query: 169 EDRLDKTEQ----------------------------SLASELEKLKSLTLSFVSERKYL 200
LDK ++ SL++EL KLK+ ++ ++L
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKN---AYEESLEHL 1497
Query: 201 NEKEKENEKL---IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
++EN+ L I +LT++L + K + + LE L ++ + S E
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557
Query: 258 ----KGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI-KHFESLEEEL 312
+ L++ Q++ E K EK+ E K ++ + ++ L+T + S E L
Sbjct: 1558 GKILRAQLEF-NQIKAEIERKLA-EKDEEMEQAK-RNHQRVVDSLQTSLDAETRSRNEVL 1614
Query: 313 KKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHE 372
+ K DL + + + N++ A +++K Q L++ +++ +DA ++ E
Sbjct: 1615 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK---SLQSLLKDTQIQLDDAVRANDDLKE 1671
Query: 373 R---TKFRGHGSEASVSKHTARELSPQHKRER-LRNREFALNNENYSLSNRQVSSPSFTN 428
+ R + +A + + R + Q +R R L +E +E L + Q + S N
Sbjct: 1672 NIAIVERRNNLLQAELEE--LRAVVEQTERSRKLAEQELIETSERVQLLHSQ--NTSLIN 1727
Query: 429 RRAAKAS---HMGVSTDSGTQETKKTEDRFVPGSSQS-----EGKKSREQPSVLSRYPPA 480
++ S + + QE + E++ + + E KK ++ + L R
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1787
Query: 481 AQEHSKAWKGTSKPGTESGLKG 502
++ K + + LKG
Sbjct: 1788 MEQTIKDLQHRLDEAEQIALKG 1809
Score = 62.8 bits (151), Expect = 2e-09
Identities = 92/434 (21%), Positives = 196/434 (45%), Gaps = 33/434 (7%)
Query: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
K + + D LL +Q + G + ++ + +L+ ++E+ ++ +KE
Sbjct: 804 KKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKE 863
Query: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKND----CTQLCLSLNEERNLTKK 150
LE+ E +EL+ ++ L + +L+ +A + ND C QL + + K+
Sbjct: 864 TLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKE 923
Query: 151 ISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--E 208
++ LE EL + + +L+ L +++ L+ LTL+ V + K+ E + +N E
Sbjct: 924 MNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE-LTLAKVEKEKHATENKVKNLTE 982
Query: 209 KL--IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLK- 265
++ + E+ KL + KK ++ + A +DL++E+ ++L + + + +D L+
Sbjct: 983 EMAGLDEIIAKLTKEKKALQEAHQQA----LDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038
Query: 266 --QVENETRNKSENEKNRNQEDNKVKD---LNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
+ E + R E K + + D K+ ++ E +KL+ + K + E ++ + SK
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK-LKKKEFDINQQNSKIE 1097
Query: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRH--ERTKFRG 378
D Q L Q K K +++EE++ +++ ++ +VE + LS + ER + G
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAER-TARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 379 HGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMG 438
+ + + RE Q R L E L +E ++ + + A + +G
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDL--EEATLQHE--------ATAAALRKKHADSVAELG 1206
Query: 439 VSTDSGTQETKKTE 452
D+ + +K E
Sbjct: 1207 EQIDNLQRVKQKLE 1220
Score = 57.8 bits (138), Expect = 5e-08
Identities = 54/267 (20%), Positives = 117/267 (43%), Gaps = 15/267 (5%)
Query: 23 LSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
L L+EL E+ ++ + AE EL++ ++V N+S++ + + + + +++
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS- 1741
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
E++ A CR +EK ++ + E+++ Q A LE++++ ++ D
Sbjct: 1742 --EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-- 1797
Query: 139 LSLNEERNLTKKISS-ELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
L+E + K +L+ L +V+ELE + EQ +E K + + E
Sbjct: 1798 -RLDEAEQIALKGGKKQLQKLEARVRELEGELE----AEQKRNAESVKGMRKSERRIKEL 1852
Query: 198 KYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
Y E++K+N +++L KL+ K + A +L + L E R
Sbjct: 1853 TYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1912
Query: 258 KGGLDYLKQVENETRNKSENEKNRNQE 284
+ ++ ++R+ +K ++E
Sbjct: 1913 DIAESQVNKLRAKSRDIGAKQKMHDEE 1939
Score = 42.7 bits (99), Expect = 0.002
Identities = 41/187 (21%), Positives = 91/187 (48%), Gaps = 9/187 (4%)
Query: 7 YKETASSRHLRFKLQS-LSRRLDELEEATKNLQKAEDELLD-LQDKVIQAEG--SNSSML 62
+ + S + + K++S L++ E+EEA + + AE++ + D + AE
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 63 AEIEVLRQRVLR-IEGKDEEIKRAEDLC-RLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
A +E +++ + + I+ + AE + + K++L++ E REL+ E+E QKR AE
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
K +S+ +L E++ ++ ++ L++KVK + + ++ +
Sbjct: 1839 VK---GMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895
Query: 181 SELEKLK 187
S+ K++
Sbjct: 1896 SKFRKVQ 1902
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 81.3 bits (199), Expect = 5e-15
Identities = 89/397 (22%), Positives = 169/397 (42%), Gaps = 46/397 (11%)
Query: 21 QSLSRRLDELEEATK--NLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
Q L ++L E K N ++ EL + +++ + LA++E Q E +
Sbjct: 340 QQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQ 399
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
++E KR +L + ++++ E E E + EIER + ELE+ + +N +L
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERNRRQELL 458
Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
N+E+ ++ +L+ K K LE + L+ + L KL+ + ++R+
Sbjct: 459 NQRNKEQ-------EDIVVLKAKKKTLEFELEALNDKKHQLEG---KLQDIRCRLTTQRQ 508
Query: 199 YLNEKEKENEKLIKELT---QKLEQNKKM-------NRDYTRNASNLERNDLRIED--GI 246
+ K E I E+T Q+L+++++M + +++N L + +
Sbjct: 509 EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL 568
Query: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
L +KE R+ D L +VE ETR+K QEI+ Q+K
Sbjct: 569 KRALEAKELARQHLRDQLDEVEKETRSKL-----------------QEIDIFNNQLKELR 611
Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGEDAFL 365
+ + + K K+ + + EQ + + L Q EE + + +++ + V+ ED
Sbjct: 612 EIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671
Query: 366 SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERL 402
+ HE K + E SV K E Q +++L
Sbjct: 672 RPRKLHEEEKLK---REESVKKKDGEEKGKQEAQDKL 705
Score = 35.8 bits (81), Expect = 0.22
Identities = 35/168 (20%), Positives = 75/168 (44%), Gaps = 13/168 (7%)
Query: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
++Q S D L + L+ E L+D++ + E S L EI++ ++
Sbjct: 554 QVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQL------ 607
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
+E++ + +L K+K E E L + + ++++ ELEK +E R + +
Sbjct: 608 -KELREIHNKQQLQKQKSMEAERLKQ------KEQERKIIELEKQKEEAQRRAQERDKQW 660
Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
L ++ + ++ E ++K +E +D +K +Q +L +L
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRL 708
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 81.3 bits (199), Expect = 5e-15
Identities = 89/397 (22%), Positives = 169/397 (42%), Gaps = 46/397 (11%)
Query: 21 QSLSRRLDELEEATK--NLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
Q L ++L E K N ++ EL + +++ + LA++E Q E +
Sbjct: 340 QQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQ 399
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
++E KR +L + ++++ E E E + EIER + ELE+ + +N +L
Sbjct: 400 EQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERNRRQELL 458
Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK 198
N+E+ ++ +L+ K K LE + L+ + L KL+ + ++R+
Sbjct: 459 NQRNKEQ-------EDIVVLKAKKKTLEFELEALNDKKHQLEG---KLQDIRCRLTTQRQ 508
Query: 199 YLNEKEKENEKLIKELT---QKLEQNKKM-------NRDYTRNASNLERNDLRIED--GI 246
+ K E I E+T Q+L+++++M + +++N L + +
Sbjct: 509 EIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL 568
Query: 247 SSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
L +KE R+ D L +VE ETR+K QEI+ Q+K
Sbjct: 569 KRALEAKELARQHLRDQLDEVEKETRSKL-----------------QEIDIFNNQLKELR 611
Query: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGEDAFL 365
+ + + K K+ + + EQ + + L Q EE + + +++ + V+ ED
Sbjct: 612 EIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQ 671
Query: 366 SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERL 402
+ HE K + E SV K E Q +++L
Sbjct: 672 RPRKLHEEEKLK---REESVKKKDGEEKGKQEAQDKL 705
Score = 35.8 bits (81), Expect = 0.22
Identities = 35/168 (20%), Positives = 75/168 (44%), Gaps = 13/168 (7%)
Query: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
++Q S D L + L+ E L+D++ + E S L EI++ ++
Sbjct: 554 QVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQL------ 607
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
+E++ + +L K+K E E L + + ++++ ELEK +E R + +
Sbjct: 608 -KELREIHNKQQLQKQKSMEAERLKQ------KEQERKIIELEKQKEEAQRRAQERDKQW 660
Query: 139 LSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKL 186
L ++ + ++ E ++K +E +D +K +Q +L +L
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRL 708
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 80.9 bits (198), Expect = 6e-15
Identities = 100/511 (19%), Positives = 212/511 (41%), Gaps = 56/511 (10%)
Query: 7 YKETASSRHLRFKLQSLSRRLD-----------ELEEATKNLQKAEDELLDLQDKVIQAE 55
Y+ T ++ L+ K L +L ++E + L++A+ L +Q +Q E
Sbjct: 176 YRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 235
Query: 56 GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMK-------EKLEEEENLTRELKS 108
M + E LR++ +I ++E++ R E+ R + EK+ +E RE +
Sbjct: 236 -----MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 109 EIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESS 168
E+ +K + E +KL E + + ++ + R +K+ + E L + K++
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350
Query: 169 EDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEK-ENEKLIKELTQKLEQNKKMNRD 227
E ++ E+ + + E+L+ + K ++EK + E+ I+E +K+ + ++ R+
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMRE 410
Query: 228 YTRNASNLERN--DLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQED 285
E N + ++ LP ++ + + K E E + + EK R+QE+
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL---WEQEKMQEQEEKIWEQEEKIRDQEE 467
Query: 286 --NKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEI 343
+ K + ++ EK++ Q EE+++ + K D Q+ + EQ++ +L E
Sbjct: 468 MWGQEKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKMWD-QEERMWEQDE------RLREK 519
Query: 344 KLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLR 403
+ ++++QK++ E K R K T + + ER+R
Sbjct: 520 EERMREQKKMWQQE----------------EKMREEKKTQEQEKKTWDQEEKMREEERMR 563
Query: 404 NREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSE 463
RE + E + ++ + + M + ++ +K ++ Q E
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 464 GKKSREQPSVLSRYPPAAQE-HSKAWKGTSK 493
K +EQ ++ QE K W+ K
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Score = 59.7 bits (143), Expect = 1e-08
Identities = 66/348 (18%), Positives = 158/348 (45%), Gaps = 26/348 (7%)
Query: 26 RLDELEEATKNLQKA--EDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIK 83
RL E EE + +K ++E + ++++ + E M E E +R++ +++ ++E +
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIRERE---KKMREEEETMREQEEKMQKQEENMW 423
Query: 84 RAEDL----CRL--MKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL 137
E+ RL KEKL E+E +++ + E++ ++ ++ EE + + K Q
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQE----KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ- 478
Query: 138 CLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSER 197
+ R ++ + E +R + +++ E+R+ + ++ L + E+++ + E
Sbjct: 479 ----EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE 534
Query: 198 KYLNEKE-KENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESR 256
K EK+ +E EK + +K+ + ++M + E + E +E
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Query: 257 RKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEI-----EKLKTQIKHFESLEEE 311
K K E E + + EK QE+ +E+ EK++ Q + EE+
Sbjct: 595 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Query: 312 LKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
+++ + K + ++ ++ K + +++ + ++++Q+E G+ E
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEE 702
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/206 (17%), Positives = 100/206 (48%), Gaps = 6/206 (2%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
K+T + + R + + E K +++ E+ + + ++K+ + E M + E
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE---EKMREQEEK 596
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKE--KLEEEENLTRELKSEIERLQKRMAELE-KLE 124
+ ++ +++ ++E++ E+ +E K++E+E + E + +++ +++M E E K+
Sbjct: 597 MWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656
Query: 125 EAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
E + + ++ + R +K+ + E +R + +++ E+++ E+ + + E
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEE 716
Query: 185 KLKSLTLSFVSERKYLNEKEKENEKL 210
K+ E + ++KEK E+L
Sbjct: 717 KMWGQEEMREKEERIRDQKEKMQERL 742
Score = 40.0 bits (92), Expect = 0.012
Identities = 25/119 (21%), Positives = 68/119 (57%), Gaps = 10/119 (8%)
Query: 28 DELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAED 87
++++E + + + E+++ + ++K+ + E M + E +R++ +++G++E+++ E+
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQE---EKMQGQEEKMREQEEKMQGQEEKMREQEE 695
Query: 88 LCRLMKEKL--EEEENLTRELK----SEIERLQKRMAEL-EKLEEAFSRSKNDCTQLCL 139
R +EK+ +EE+ +E K E+ ++R+ + EK++E + C++ CL
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCL 754
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 80.9 bits (198), Expect = 6e-15
Identities = 140/647 (21%), Positives = 266/647 (41%), Gaps = 63/647 (9%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
K ++ + L + L + ++EL L+ +E + DL + + E + + AEI
Sbjct: 462 KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITK 521
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
LR RV DL + L+ E + R +++E E L+ +M E +K+ E
Sbjct: 522 LRSRV--------------DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL 567
Query: 128 SRSKNDCTQLCLSLNEERNLTK----KISSELEMLRVKVKELESSEDRLDKTEQSLAS-- 181
+ + TQL + ++ E+ R+++KEL+ +D+ D + L +
Sbjct: 568 RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627
Query: 182 ---ELEKLKSLTLSFVSER-KYLNEKEKENEKLIKELTQKLEQNKKMNRDY---TRNASN 234
ELEK+K + SER + + + ++E ++L+ E+ + ++ +Y RN N
Sbjct: 628 SDLELEKVKLVNAG--SERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRN 685
Query: 235 LERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE----NEKNRNQEDNKVKD 290
+ + L S +S + + LK +E + + +K + ++
Sbjct: 686 KSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDA 745
Query: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
L +I+ L+ + + + LK+ KSK + +E+NK +A +LE ++ Q ++
Sbjct: 746 LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNK---MAGELEVLRSQERRL 802
Query: 351 KE-LENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT--ARELSPQHKRERLRNREF 407
KE + N EV + A L + + + S +HT +EL +
Sbjct: 803 KEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPR 862
Query: 408 ALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKS 467
L + + S+ V S T A+ SH ST + T + T D + Q
Sbjct: 863 LLQPASVTRSHSNVPSSQST---ASFLSHH--STKANTLKEDPTRD--LKQLLQELRSVI 915
Query: 468 REQPSV-LSRYPPAAQEHSKAWKGTSKPG-----TESGLKGKV-EKTTRTFSDTTHGSVP 520
E+P+V LS+ +E + G + TES L+ + ++ + D+T GS
Sbjct: 916 NEEPAVSLSK----TEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKS 971
Query: 521 SDPLGR------ADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSS 574
S+ L R A D S F S +S + +L +S
Sbjct: 972 SETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEG 1031
Query: 575 SEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFST 621
S G + ++A + + +S +S++P + +CR +N L+ T
Sbjct: 1032 SIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQT 1078
Score = 57.4 bits (137), Expect = 7e-08
Identities = 86/398 (21%), Positives = 170/398 (42%), Gaps = 54/398 (13%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLD-LQDKVIQAEGSN---SSML----AEIEV 67
L+ KLQ + D + + + +++++L + LQ+ V + E + ML +IE
Sbjct: 115 LQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQ 174
Query: 68 LRQRVLRIEGKDEEIKRA-EDLCRLMKEKLEEEENLT---------------RELKSEIE 111
LR+ +L EG +EI+ D +K+ E ++++ REL +EI
Sbjct: 175 LRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEIS 234
Query: 112 RLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDR 171
L+ R+ +E EA + +L L +++R +++ SE E V++ L
Sbjct: 235 YLKGRIFPVEDQLEALKSESQNKIELLLQQHQDR--IEQLISEHE---VEITGLTEKASS 289
Query: 172 LDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRN 231
S+ S++E ++ + + + + E + +L +L + K+M D T
Sbjct: 290 ARSQANSIQSQMEIIQEQARN---QNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEE 346
Query: 232 ASNLERNDLRIEDGISSTLPSKE--SRRKGGLDYLKQVENETRNKSENEKNRNQEDNK-- 287
LE+ + ++ ++ S+ G LD Q +K E E + +E NK
Sbjct: 347 ---LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRL 403
Query: 288 ----------VKDLNQEIEKLKTQIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLL 336
+ L +E++ +++ E+L LK +KS+ ++ + Q KN+ L
Sbjct: 404 WDRDTGNSITIDHLRRELDNRNMEVQRLEAL---LKALKSECQGQMERQMAAIQGKNESL 460
Query: 337 ASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
++ + Q++ KE+ VE A + ERT
Sbjct: 461 -EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT 497
Score = 54.3 bits (129), Expect = 6e-07
Identities = 83/370 (22%), Positives = 160/370 (43%), Gaps = 42/370 (11%)
Query: 20 LQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSN--SSMLAEIEVLRQRVLRIEG 77
LQ + L + EEA+ D + L + + + S + EI L+ R+ +E
Sbjct: 186 LQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
Query: 78 KDEEIKRAED--LCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
+ E +K + L+++ + E L E + EI L EK A S++ + +
Sbjct: 246 QLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT------EKASSARSQANSIQS 299
Query: 136 QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
Q+ + + RN +L L V +L S + + ELEK L S ++
Sbjct: 300 QMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELT 359
Query: 196 ERKYLNEK--------EKENEKLI-------KELTQKLEQNKKMNRDYTRNASNLERNDL 240
E + ++ + + +KL+ KEL+ + EQNK++ T N+ ++
Sbjct: 360 EARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR 419
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENE----KNRNQEDNKVKDLNQEIE 296
+++ + E +R L LK +++E + + E + + +N+ KV L ++E
Sbjct: 420 ELDN------RNMEVQRLEAL--LKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLE 471
Query: 297 KLKTQI-KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLL-ASQLEEIKLQIK---KQK 351
K + K E L + ++S + D S Q K + + A+ E KL+ + K +
Sbjct: 472 STKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQ 531
Query: 352 ELENGEVEGE 361
EL++ + EG+
Sbjct: 532 ELQHLKNEGD 541
Score = 46.6 bits (109), Expect = 1e-04
Identities = 74/402 (18%), Positives = 174/402 (43%), Gaps = 36/402 (8%)
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
+E + +DL R + E E E L+ + LQ ++ E++ +A + + +Q
Sbjct: 81 EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ-- 138
Query: 139 LSLNEERNLTKKISSELEMLR-VKVKELESSEDRLDKTEQSLASE---LEKLKSLTLSFV 194
S + RN + ELE + +K L+ S ++++ + + S L++++S+ + F
Sbjct: 139 -SQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFE 197
Query: 195 -SERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
+ K + E + + + L + K+ R+ S L+ +ED + +
Sbjct: 198 EASGKKICEHDSMSTLHFRSLGSAIS---KILRELDTEISYLKGRIFPVEDQLEAL--KS 252
Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK 313
ES+ K ++ L Q +++ E+ ++ + ++ L ++ ++Q S++ +++
Sbjct: 253 ESQNK--IELLLQ-----QHQDRIEQLISEHEVEITGLTEKASSARSQAN---SIQSQME 302
Query: 314 KMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER 373
++ + + Y+ + + + SQL + K+ E + E+E + +S+ R
Sbjct: 303 IIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEAR 362
Query: 374 TKFRGHGSEA-SVSKHTARELSPQHKRERLRNREFALNNE-NYSLSNRQVSSPSFTNRRA 431
T+ E+ ++ + L+ HKRE +E +L E N L +R + +
Sbjct: 363 TERDQFSQESGNLDDQLQKLLADLHKRE----KELSLEKEQNKRLWDRDTGN-------S 411
Query: 432 AKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSV 473
H+ D+ E ++ E S+ +G+ R+ ++
Sbjct: 412 ITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAI 453
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.5 bits (197), Expect = 8e-15
Identities = 83/424 (19%), Positives = 187/424 (44%), Gaps = 85/424 (20%)
Query: 13 SRHLRFKLQSLSRRLDELE----EATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVL 68
S L ++ L R++++L+ +A + L+K E E+ L++ ++ A ++ L
Sbjct: 838 SEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL 897
Query: 69 RQRVLRIEGK-DEEIKRAEDLCRLMKEKLEEEENLTR---ELKSE-------IERLQKRM 117
+ +G + + + L +KE+ E++E L R E+++E IE+LQK M
Sbjct: 898 ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEM 957
Query: 118 AEL------------EKLEEAFSRSKNDCTQLCLSLNEE-------RNLTKKISSELEML 158
A++ +L+E +++ + ++ L E+ R K+ E+ ++
Sbjct: 958 ADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLM 1017
Query: 159 RVKVKELESSEDR-------LDKTEQSLASELE------------------KLKSLTLSF 193
++++ + ++D L++T + L ELE K+ L +
Sbjct: 1018 EEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMEL 1077
Query: 194 VSERK---YLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTL 250
ER L+E+ + + +++L +L Q + +D + +LER + ++ I
Sbjct: 1078 EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137
Query: 251 PSKESRRKGGLDYLK--------QVENETRNKSENEKNRNQEDNKVKDLNQEIE------ 296
S S ++G + ++ ++E+E R+++ + + + + KVK+L +++
Sbjct: 1138 GSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197
Query: 297 ---------KLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
+LK + E EEE+ +++S LQ + + N+ L QL +K +
Sbjct: 1198 TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
Query: 348 KKQK 351
+ +K
Sbjct: 1258 RLKK 1261
Score = 75.5 bits (184), Expect = 3e-13
Identities = 84/360 (23%), Positives = 166/360 (46%), Gaps = 43/360 (11%)
Query: 28 DELEEATKNLQ-------KAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG--- 77
+ +EEATKN++ +E + + +V + N + E L +RV +++
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 78 --KDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMA---ELEKLEEAFSRSKN 132
K +E K E L + E + EE L K E E + R A ELE + S++
Sbjct: 854 DLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQ 913
Query: 133 DCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
+ QL L EE S + E LR E+E+ L KT + L E+ + + +
Sbjct: 914 EQKQLSEKLKEE-------SEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRT 966
Query: 193 FVSE-RKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRI-EDGISSTL 250
E + L+E +++N + + E+ ++L++ K + + +R + ++++R+ E+ +
Sbjct: 967 STLELQNQLDEYKEKNRRELAEMQRQLKE-KTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 251 PSKE---SRRKGGLDYLKQVENETRNKSENEKNRN----QEDNKVKDLNQEIE------- 296
+++ ++R+ LK +E E KS + +R+ Q ++KV L E+E
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSD 1085
Query: 297 ----KLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE 352
++ + E L EL + ++ DL+ + +S + +NK L S++ ++ + KE
Sbjct: 1086 LLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
Score = 72.8 bits (177), Expect = 2e-12
Identities = 96/428 (22%), Positives = 198/428 (46%), Gaps = 54/428 (12%)
Query: 29 ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDL 88
+L+ KN Q ++E ++ + + ++ + E L+QR+ EG E K E+L
Sbjct: 629 QLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG--ELRKNLEEL 686
Query: 89 CRLMKEKLEEEENLTRELKSEIERLQ------KRMAELEK--LEEAFSRSKNDCTQLCLS 140
++ E+ E+ + R+L+ ++ + KR + EK L E ++K D L ++
Sbjct: 687 FQVKMER-EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745
Query: 141 LNEERNLTKKISSELEMLRVKVKELESSEDR-LDKTEQSLASELEKLK------SLTLSF 193
E+ +L +K EL L+ +KE SS D+ +DK ++ +EL+ L+ + +
Sbjct: 746 KEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV 805
Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKM---NRDYTRNASNLERNDLRIEDGISSTL 250
++ R +E+++ ++ +L Q E+N+K+ + + R + L+R +IED L
Sbjct: 806 LASRSNTSEQDQAGTEMRVKLLQ--EENEKLQGRSEELERRVAQLQR---QIED-----L 855
Query: 251 PSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKV----KDLNQEIE----KLKTQI 302
E++ K + LK+ E E R E + +E+ + + L E+E L
Sbjct: 856 KGDEAKAK---ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTT 912
Query: 303 KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ---IKKQKELENGEVE 359
+ + L E+LK+ + L+ +N+ L +E+++ + I + E++
Sbjct: 913 QEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ 972
Query: 360 GEDAFLSSKGRHE----RTKFRGHGSEASVSKHTARELSPQHK--RERLRNREFALNNEN 413
+ K R E + + + EA S+ TA ++ + + E LR+ + A ++
Sbjct: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA---QD 1029
Query: 414 YSLSNRQV 421
+L+ RQ+
Sbjct: 1030 EALTKRQL 1037
Score = 65.1 bits (157), Expect = 3e-10
Identities = 86/420 (20%), Positives = 169/420 (40%), Gaps = 42/420 (10%)
Query: 21 QSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML--------AEIEVLRQRV 72
Q L L EE L+K E EL L+ + + S+ + AE++ LR+ V
Sbjct: 737 QDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESV 796
Query: 73 LRIEGKDEEIKRAEDLCRLMKEKLEEE---ENLTRELKSEIERLQKRMAELEKLEEAFSR 129
+E K E L +++ E + L+ E E+LQ R ELE+ R
Sbjct: 797 ------EEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQR 850
Query: 130 SKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSL 189
D L + + KK E+ L + E ++L +ELE +
Sbjct: 851 QIED---LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 190 TLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISST 249
E+K L+EK +KE +++ EQ +++ + +L + +++ ++
Sbjct: 908 LSQTTQEQKQLSEK-------LKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 250 LPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLE 309
+ E+ R L+ Q++ E + K+ E Q K K L E +L ++
Sbjct: 961 V---EASRTSTLELQNQLD-EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM-----KMQ 1011
Query: 310 EELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENG------EVEGEDA 363
+E++ M+ + D Q K +LL L++++ +++ + L++ ++E + +
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071
Query: 364 FLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSS 423
L + ER S S+ +L + +ER ++ + + N+ + S
Sbjct: 1072 QLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKS 1131
Score = 62.4 bits (150), Expect = 2e-09
Identities = 77/348 (22%), Positives = 156/348 (44%), Gaps = 41/348 (11%)
Query: 23 LSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK--DE 80
L + L+EL + ++ + E+ DLQD++ S M E++ ++ R +G +E
Sbjct: 679 LRKNLEELFQVKMEREQHQTEIRDLQDQL-------SEMHDELDSAKRSEDREKGALIEE 731
Query: 81 EIKRAEDLCRLMKEKLEEEENLTRELKSEI--------ERLQKRMAELEKLEE------- 125
++ +DL L+ K EE+E+L R+ + E+ E + E++KL+E
Sbjct: 732 LLQAKQDLQDLLIAK-EEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ 790
Query: 126 AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
A S + T+ L N +++ + EM +VK L+ ++L + L + +
Sbjct: 791 ALRESVEEATKNVEVLASRSNTSEQDQAGTEM---RVKLLQEENEKLQGRSEELERRVAQ 847
Query: 186 LKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDG 245
L+ + E K+ E I++L + L +K ++ LE N+L G
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE-NELEAAQG 906
Query: 246 ISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
S ++ + ++++ E+ K + + +N+ +N+ L + IEKL+ K
Sbjct: 907 NLSQTTQEQKQLS------EKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQ---KEM 957
Query: 306 ESLEEELKKMKSKNNDLQDNYLSEQNKNKL--LASQLEEIKLQIKKQK 351
+ E + + + D Y E+N+ +L + QL+E L+ +K +
Sbjct: 958 ADIVEASRTSTLELQNQLDEY-KEKNRRELAEMQRQLKEKTLEAEKSR 1004
Score = 52.8 bits (125), Expect = 2e-06
Identities = 72/284 (25%), Positives = 129/284 (45%), Gaps = 56/284 (19%)
Query: 9 ETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV- 67
E SR K+Q R + EE ++ Q+A+DE L + + Q L ++E
Sbjct: 999 EAEKSRLTAMKMQDEMRLM---EEELRDYQRAQDEALTKRQLLEQT-------LKDLEYE 1048
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL--EKLEE 125
L + + + +K+ ED ++ +LEEE N + L I R +++M +L E L+E
Sbjct: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108
Query: 126 AFSRSKNDCTQLCLSLNEERNLTKKI-------SSELEMLRVKVK-ELESSEDRLDKTEQ 177
+R +C ++ L + ++L +I S E L V+++ + EDRL+ E+
Sbjct: 1109 RAARQDLECDKISLE-RQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 178 SLAS------ELE-KLKSLTLSFVSE------------------RKYLNEKEKENEKL-- 210
A+ LE K+K L + E ++ + E E+E ++L
Sbjct: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227
Query: 211 -IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
K+L ++LE+ MN ++ + N + DLR++ LPSK
Sbjct: 1228 SKKKLQRELEEQMDMN-EHLQGQLNSMKKDLRLK-----KLPSK 1265
Score = 49.3 bits (116), Expect = 2e-05
Identities = 84/346 (24%), Positives = 157/346 (45%), Gaps = 63/346 (18%)
Query: 82 IKRAEDLCRLMKEKLEEE--ENLTRELKSEIERLQKRMAEL--EKLEEAFSRSKNDC--- 134
+K ++L + E+ ++ N +E ++ + KR L EK++ SR+
Sbjct: 540 LKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGN 599
Query: 135 TQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFV 194
Q C S +E ++L ++ S L ++V EL+ K +Q++ E E++++ +
Sbjct: 600 NQACNSTSEVKDLLEQKSK----LTIEVAELQRQLQLEVKNQQNIKEERERMRA---NLE 652
Query: 195 SERKYLNEKEKENEKLIK-------ELTQKLEQ--NKKMNRD-YTRNASNLERNDLRIED 244
R NEK +EN L + EL + LE+ KM R+ + +L+ + D
Sbjct: 653 ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
Query: 245 GISSTLPSKESRRKGGL-DYLKQVENETRN----KSENE---KNRNQE--------DNKV 288
+ S S E R KG L + L Q + + ++ K E E + R +E +V
Sbjct: 713 ELDSAKRS-EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEV 771
Query: 289 KDLNQEIEKLKTQIKH-----FESLEEELKKMK----SKNNDLQDNYLSE------QNKN 333
+QE++KLK Q ES+EE K ++ N QD +E Q +N
Sbjct: 772 SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEEN 831
Query: 334 KLLASQLEEIKLQIKK-QKELENGEVEGEDAFLSSKGRHERTKFRG 378
+ L + EE++ ++ + Q+++E +++G++A K + K+ G
Sbjct: 832 EKLQGRSEELERRVAQLQRQIE--DLKGDEA----KAKETLKKYEG 871
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 80.1 bits (196), Expect = 1e-14
Identities = 94/436 (21%), Positives = 190/436 (43%), Gaps = 63/436 (14%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQA------ 54
+A+ T K+ H + L L D++ TK K E ++ DL+ + Q
Sbjct: 989 IAKLTKEKKALQEAHQQ-ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD 1047
Query: 55 -EGSNSSMLAEIEVLRQRVLRIEGK----DEEIKRAEDLCRLMKEKLEEEENLTRELKSE 109
E + + ++++ ++ ++ +E DE +K+ + + ++E+E+ L +L+ +
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKK 1107
Query: 110 IERLQKRMAEL--------------EKLEEAFSRSKND----------CTQLCLSLNEER 145
++ LQ R+ EL EKL SR + T + + +N++R
Sbjct: 1108 LKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167
Query: 146 NLT-KKISSELE-----------MLRVK----VKELESSEDRLDKTEQSLASELEKLKSL 189
+K+ +LE LR K V EL D L + +Q L E + K
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227
Query: 190 TLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNL--ERNDLRIEDG-I 246
S + + + + EK+ + L ++ +++ + R+ ++L +R L+ E+G +
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL 1287
Query: 247 SSTLPSKES----RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI 302
S L KE+ +G L Y +Q+E+ R E K +N + ++ + + L+ Q
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 303 KHFESLEEELKKMKSKNNDLQDNYLSEQNKNKL-LASQLEEIKLQIKKQKELENGEVEGE 361
+ + EL+++ SK N + ++ + + +LEE K ++ ++ + VE
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 362 DAFLSSKGRHERTKFR 377
+A SS E+TK R
Sbjct: 1408 NAKCSSL---EKTKHR 1420
Score = 67.4 bits (163), Expect = 7e-11
Identities = 91/431 (21%), Positives = 195/431 (45%), Gaps = 32/431 (7%)
Query: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
M + K S ++ S+ L+EA L+K+E +L++K++ S
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEA---LEKSEARRKELEEKMV-------S 879
Query: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLC-RLMKEKLEEEENLTRELKSEIERLQKRMAE 119
+L E L+ L+++ + + + AE+ C +L+K K++ E + +E+ +E ++ AE
Sbjct: 880 LLQEKNDLQ---LQVQAEQDNLADAEERCDQLIKNKIQLEAKV-KEMNERLEDEEEMNAE 935
Query: 120 LEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSL 179
L + + +++C++L +++ K+ E KVK L LD+ L
Sbjct: 936 LTAKKR---KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Query: 180 ASELEKLKSLTLSFV----SERKYLNEKEKENEKL---IKELTQKLEQNKKMNRDYTRNA 232
E + L+ + +E +N K KL + +L LEQ KK+ D R
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1052
Query: 233 SNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN-RNQEDNKVKDL 291
LE DL++ L + + + L N + E+E+ +Q K+K+L
Sbjct: 1053 RKLE-GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 292 NQEIEKLKTQIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
IE+L+ +++ + +++K++S + +L++ +SE+ + A+ + +I++ K++
Sbjct: 1112 QARIEELEEELEAERTARAKVEKLRSDLSRELEE--ISERLEEAGGATSV-QIEMNKKRE 1168
Query: 351 KELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALN 410
E + + E+A L + + + S A + + + K E+ ++ EF L
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS-EFKLE 1227
Query: 411 NENYSLSNRQV 421
++ + + Q+
Sbjct: 1228 LDDVTSNMEQI 1238
Score = 66.6 bits (161), Expect = 1e-10
Identities = 116/548 (21%), Positives = 231/548 (42%), Gaps = 79/548 (14%)
Query: 17 RFKLQS----LSRRLDELEEATKNLQKAE----DELLDLQDKVIQAEGSNSSMLAEIEVL 68
R KLQ+ LSR+LDE E L + + +L DL+ ++ + + +++ ++
Sbjct: 1277 RAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA 1336
Query: 69 RQRV-LRIEGKDEEIKRAEDLCRLMK---------------------EKLEE-EENLTRE 105
R L E +EE + +L R++ E+LEE ++ L +
Sbjct: 1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 106 LKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN-----------EERNLTKKISSE 154
L+ E ++ A+ LE+ R +N+ L + + ++RN K ++
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456
Query: 155 LEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKL---I 211
+ ELESS+ K +SL++EL KLK+ ++ ++L ++EN+ L I
Sbjct: 1457 KQKYEESQSELESSQ----KEARSLSTELFKLKN---AYEESLEHLETFKRENKNLQEEI 1509
Query: 212 KELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR----KGGLDYLKQV 267
+LT++L + K + + LE + ++ + S E + L++ Q+
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF-NQI 1568
Query: 268 ENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQI-KHFESLEEELKKMKSKNNDLQDNY 326
+ E K EK+ E K L + ++ L+T + S E L+ K DL +
Sbjct: 1569 KAEIERKLA-EKDEEMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHER---TKFRGHGSEA 383
+ + N++ A +++K Q L++ +++ +DA ++ E + R + +A
Sbjct: 1627 IQLSHANRMAAEAQKQVK---SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 384 SVSKHTARELSPQHKRER-LRNREFALNNENYSLSNRQVSSPSFTNRRA---AKASHMGV 439
+ + R + Q +R R L +E +E L + Q + S N++ A S +
Sbjct: 1684 ELEE--LRAVVEQTERSRKLAEQELIETSERVQLLHSQ--NTSLINQKKKMDADLSQLQT 1739
Query: 440 STDSGTQETKKTEDRFVPGSSQS-----EGKKSREQPSVLSRYPPAAQEHSKAWKGTSKP 494
+ QE + E++ + + E KK ++ + L R ++ K +
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 495 GTESGLKG 502
+ LKG
Sbjct: 1800 AEQIALKG 1807
Score = 52.8 bits (125), Expect = 2e-06
Identities = 57/273 (20%), Positives = 120/273 (43%), Gaps = 29/273 (10%)
Query: 23 LSRRLDEL----EEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
L L+EL E+ ++ + AE EL++ ++V N+S++ + + + + +++
Sbjct: 1681 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ-- 1738
Query: 79 DEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLC 138
E++ A CR +EK ++ + E+++ Q A LE++++ ++ D
Sbjct: 1739 -TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH-- 1795
Query: 139 LSLNEERNLTKKISS-ELEMLRVKVKELESS----EDRLDKTEQSLASELEKLKSLTLSF 193
L+E + K +L+ L +V+ELE+ + R ++ + + ++K LT
Sbjct: 1796 -RLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT--- 1851
Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
Y E++++N +++L KL+ K + A +L + L
Sbjct: 1852 -----YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1906
Query: 254 ESRRKGGLDYLKQVENETRNKSEN--EKNRNQE 284
E R D + N+ R KS + K N+E
Sbjct: 1907 EER----ADIAESQVNKLRAKSRDIGTKGLNEE 1935
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 79.7 bits (195), Expect = 1e-14
Identities = 103/482 (21%), Positives = 201/482 (41%), Gaps = 79/482 (16%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSM------ 61
+ T L K++ ++++L E +++ + E E L+++ + I E N +
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAEN-DRDILRREQEQLNVEKRQIMEECENLKLECSKLQ 361
Query: 62 -----LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRE--LKSEIERLQ 114
++ ++R+L EE+ R + + ++ +L ++ L + +L+
Sbjct: 362 PSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLK 421
Query: 115 KRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK-------ISSELEMLRVKVKELES 167
R+ LEK + S+ K + L LN E + K + SEL LR+ ++ E
Sbjct: 422 MRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQ 481
Query: 168 SEDRLDKTEQSLASELEKL----KSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKK 223
++ +++L +E+E+L + T + + L++++ E + +I +L Q L KK
Sbjct: 482 ELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKK 541
Query: 224 M-------NRDYTRNA---------SNLERNDLRIE------------DGISSTLPSKES 255
D T+ S + NDL + D ++ + S S
Sbjct: 542 RVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVS 601
Query: 256 RRKGGLDY----------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHF 305
+K L+ L ++ NE + N N +D +K+ E+ LK +
Sbjct: 602 IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
Query: 306 ESLEEELKK----MKSKNNDLQDNYLSEQNKNKL---LA--SQLEEIKLQIKKQKELENG 356
E L E LKK +K +N L E +++L LA +QL K I + ++E G
Sbjct: 662 EQLNENLKKVAFDVKMENEKLV--LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKG 719
Query: 357 EVEGEDAFLSSKGRHERTKFRGHGSEASVSKH---TARELSPQH--KRERLRNREFALNN 411
E+E E + + E K+ E S +++ +A +L +H K + ++ E A
Sbjct: 720 EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK 779
Query: 412 EN 413
+N
Sbjct: 780 KN 781
Score = 71.6 bits (174), Expect = 4e-12
Identities = 104/446 (23%), Positives = 193/446 (43%), Gaps = 69/446 (15%)
Query: 12 SSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQR 71
+++H+ LS++ +E + + K + +L D + +V Q E + E++V +++
Sbjct: 507 ATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK 563
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEE-ENLTRELKSEIER---LQKRMAELEKL---- 123
+++ E ++ L K+KLE++ ENL +L E +QK EL++
Sbjct: 564 LIQSEVALNDL-------HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
Query: 124 EEAFSRSKNDCTQLCLSLNEERN------LTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
EE SR +N+ Q SLN++ N L K+ +E+ L+ + ELE + L K
Sbjct: 617 EEELSRIRNELMQ---SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+ E EKL L+ R L E N +L E +E K + ++
Sbjct: 674 DVKMENEKL---VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK 730
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEK 297
L + T+ + R L Q+E+E K +K D ++ +L + IE+
Sbjct: 731 RLLEEANKYEKTIEELSNARNLNTSAL-QLEHEHLIKLNQKK-----DMEIAELKKNIEQ 784
Query: 298 LKTQIKHFE-----SLEEE-------------LKKMKSKNNDLQ---DNYLSEQNKNKLL 336
+ T K + SLEE+ ++K+K +++ LQ D Y KN++L
Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
Query: 337 ASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHT--ARELS 394
+EE + KE EN ++ E + R E+++ ++ T A E+S
Sbjct: 845 RQTIEEKDRSLGSMKE-ENNHLQEE----LERLREEQSRTAPVADPKTLDSVTELASEVS 899
Query: 395 -----PQHKRERLRNREFALNNENYS 415
+H E +++ + + ++N S
Sbjct: 900 QLNTIKEHLEEEIKHHQKIIEDQNQS 925
Score = 66.2 bits (160), Expect = 2e-10
Identities = 108/490 (22%), Positives = 212/490 (43%), Gaps = 76/490 (15%)
Query: 9 ETASSRHLRFKLQSLSRRLDELE-EATKNLQKAEDELLDLQDKVI--QAEGSNSSMLAEI 65
E++ R +Q+LSR + E + E QK + L LQ +A G NS+ E+
Sbjct: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEEL 1207
Query: 66 EVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEE 125
R ++ +++K+ E+ + + ++ ++ + +L+ E+ +LQ A++ +
Sbjct: 1208 LQERDKL------KQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ---AQVLVDSD 1258
Query: 126 AFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEK 185
S+ + D T L S + K EL ++ + +L +++D L ++ +L
Sbjct: 1259 NNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSS 1318
Query: 186 LKSLT-LSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
LT S R +E E+ +L++ Q+LE+ +K ++ L+ N+ R+ D
Sbjct: 1319 ASLLTPQSAECLRASKSEVLSESSELLQ---QELEELRKSLQEKDATIRTLQENNHRLSD 1375
Query: 245 GISST--LPSKESRR--------KGGLDYLKQVENET----RNKSENEKNRNQE-DNKVK 289
I++T L KE + K D L+++ E + KS+ + N+ NKV
Sbjct: 1376 SIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVN 1435
Query: 290 D---LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQ 346
+ L Q + LK +I LE ++ K+K +N + + Y ++ + + L + +
Sbjct: 1436 ENELLRQAVTNLKERIL---ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMM 1492
Query: 347 IKKQ------------------KELENGEVEGEDAFLSS-KGRHERTK-FRGHGSEA--S 384
++++ KE E G+ + L++ K E+T F+ + +
Sbjct: 1493 LREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552
Query: 385 VSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSG 444
+ + + Q++ +RLR++EF N E L N H+ S DS
Sbjct: 1553 LKQKQMENTALQNEVQRLRDKEFRSNQELERLRN-----------------HLLESEDSY 1595
Query: 445 TQETKKTEDR 454
T+E EDR
Sbjct: 1596 TREALAAEDR 1605
Score = 64.7 bits (156), Expect = 4e-10
Identities = 66/288 (22%), Positives = 132/288 (45%), Gaps = 29/288 (10%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVI----QAEGSNSSMLA 63
K A + L+ K Q + L++L A K++Q+ +D+V+ Q + N+++
Sbjct: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
Query: 64 EIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKL 123
E++ LR D+E + ++L RL LE E++ TRE + +R K ++ L
Sbjct: 1566 EVQRLR---------DKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVL 1616
Query: 124 EEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL 183
EE +L S N N + + S ++E L+ ++L + D+T L+
Sbjct: 1617 EE----------KLVSSSNAMENASHQASVQVESLQ---EQLNVVSKQRDETALQLSVSQ 1663
Query: 184 EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIE 243
E++K LS + + L ++E + + + +LE+ K++ ++ +NA NLE + ++
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAM---YSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720
Query: 244 DGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDL 291
+ + + +S + + E K +NE + D+ K L
Sbjct: 1721 ECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768
Score = 55.8 bits (133), Expect = 2e-07
Identities = 85/430 (19%), Positives = 175/430 (40%), Gaps = 61/430 (14%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
K S L ++ L+ + LEE K+ QK ++ + +++Q+ + E
Sbjct: 886 KTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRY 945
Query: 68 LRQRV------LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEI-ERLQKRMAEL 120
+++ L +E KDEEIK + +K +L EE + S+I + + + +
Sbjct: 946 QHEQMNATHTQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI 1004
Query: 121 EKLEEAFSRSKNDCTQLCLSLNE---------ERN--LTKKI--------SSELEMLRVK 161
E E SK + +L + E E+N LTK+I ++++ K
Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064
Query: 162 VKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERK----YLNEKEKENEKLIKE---- 213
E+++ R+ T S ++ L+ ++ ER+ LNEK +EN L E
Sbjct: 1065 DLEIQALHARISST--SHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
Query: 214 ----------LTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDY 263
L + ++NKK++ + + ++ R ++ +S + K+
Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQ---NLSRIIREKDIEIDALSQK 1179
Query: 264 LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQ 323
+ + + S + N+ ++L QE +KLK Q+ KKM+ +
Sbjct: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV----------KKMEEWKQQVM 1229
Query: 324 DNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEA 383
+ Q+++ L +L +++ Q+ + N +++ + L TK + G E
Sbjct: 1230 TTVQNMQHESAQLQEELHQLQAQVLVDSD-NNSKLQVDYTGLIQSYEQNETKLKNFGQEL 1288
Query: 384 SVSKHTAREL 393
+ +H+ +L
Sbjct: 1289 AQVQHSIGQL 1298
Score = 33.5 bits (75), Expect = 1.1
Identities = 63/330 (19%), Positives = 129/330 (39%), Gaps = 47/330 (14%)
Query: 53 QAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIER 112
Q GS +S+ +I + +L +EG +E D + +E E + L+SE ER
Sbjct: 18 QVGGSLASLTGQISNFTKDML-MEGTEEVEAELPD------SRTKEIEAIHAILRSENER 70
Query: 113 LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
L+K +LE+ EA Q+ RN ++ E+ L+ + L+ +L
Sbjct: 71 LKKLCTDLEEKHEASE------IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKL 124
Query: 173 DKTEQSLASELEKLKSLTLS----------------------FVSERKYLNEKEKENEKL 210
QS+ S + S +S ++ +N E +L
Sbjct: 125 QSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL 184
Query: 211 IKEL--TQKLEQNKKMNRDYTRNASNLERNDL-RIEDGISSTLPSKESRRKGGLDYLKQV 267
E+ + + Q K + N +++++ ++++ I ++ + +
Sbjct: 185 ESEVGHWRHIAQTSK-----AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVL 239
Query: 268 ENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFES--LEEELKKMKSKNNDLQDN 325
+N + K R++E+ + D + IE+L+ ++ S +E +L K+ +Q
Sbjct: 240 QNAHQQKLTEISRRHREE--LSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVL 297
Query: 326 YLSEQNKNKLLASQLEEIKLQIKKQKELEN 355
+ + K + ++IK KK EN
Sbjct: 298 QIEKVESTKKMEQLEDKIKDINKKLSSAEN 327
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 78.6 bits (192), Expect = 3e-14
Identities = 96/438 (21%), Positives = 184/438 (42%), Gaps = 59/438 (13%)
Query: 23 LSRRLDELEEATKNLQKAEDEL--LDLQDKVIQAE-GSNSSMLAEIEVLRQRVLRIEGKD 79
L+R++ LE AT+ ++ E E L L+++ ++ + ++ ++E L + +++ ++
Sbjct: 647 LARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAEN 706
Query: 80 EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCL 139
E++R + R KL + E ++L+ E E L+K + L+ L + K++ +L
Sbjct: 707 LELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGK-----KSERLELSY 761
Query: 140 SLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKY 199
NL ++ LE K + LES L+ Q+L +LE L+
Sbjct: 762 QSVSAENL--RLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQ------- 812
Query: 200 LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISS-TLPSKESR-- 256
L EK+ + L +E+ Q + K + ++ R +E D ++D + + KESR
Sbjct: 813 LEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRAL 872
Query: 257 -----------------RKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLK 299
K D KQV R + ++ E K + L+ E++KL
Sbjct: 873 DKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLS 932
Query: 300 TQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK-------------LLASQLEEIKLQ 346
+++ E L + +D + L +N++ LL +Q+EE K
Sbjct: 933 QELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEE-KAS 991
Query: 347 IKKQKELENGEVEGEDAFL---SSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE--- 400
+ +Q E E ++ E L +G+H + F+ + + S P HK
Sbjct: 992 LNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATME 1051
Query: 401 --RLRNREFALNNENYSL 416
R+++R L N +L
Sbjct: 1052 LLRVKDRAIELERNNAAL 1069
Score = 60.8 bits (146), Expect = 6e-09
Identities = 101/446 (22%), Positives = 181/446 (40%), Gaps = 54/446 (12%)
Query: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAE-------------- 64
KL + R +LE + L+K D L L K + E S S+ AE
Sbjct: 722 KLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHK 781
Query: 65 IEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK-- 122
+ L + +E + + ++R + RL +LE E + L+ E+ +L+K LEK
Sbjct: 782 TQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEA 841
Query: 123 -----LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQ 177
E +D T ++ +E K + K+KELE +D D T+Q
Sbjct: 842 KRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELE--KDNRDLTKQ 899
Query: 178 SLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER 237
+ L +L V E+ + E +KL +EL +K+ N+++ + S+ +
Sbjct: 900 -VTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQEL-EKVGLNRELLLQEDDSGSDTKY 957
Query: 238 NDL--RIEDGISSTLPSKESR---------RKGGLDYLKQVENETRNKSENEKNRNQEDN 286
L R E + +TL KE + K L+ +Q+E+E + + + Q
Sbjct: 958 KILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLN--RQLESELQMLKKECETLRQNQG 1015
Query: 287 KVKDLNQEIEKL--KTQIKH---------FESLEEELKKMKSKNNDLQDNYLSEQNKNKL 335
+ + L + KT H + EL ++K + +L+ N + Q + +L
Sbjct: 1016 EGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQL 1075
Query: 336 LASQLEEIKLQ-IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELS 394
L QL+ ++ Q + ++ ++ + AFL +T+ E S + L+
Sbjct: 1076 LKEQLQHLETQNVTFSSQILT--LQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALT 1133
Query: 395 PQHKRERLRNREFALNNENYSLSNRQ 420
Q+ L+N A EN SL +Q
Sbjct: 1134 AQY--TLLQNHHTAKETENESLQRQQ 1157
Score = 59.3 bits (142), Expect = 2e-08
Identities = 89/453 (19%), Positives = 177/453 (39%), Gaps = 30/453 (6%)
Query: 29 ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDL 88
EL + L++ EL D ++++ ++ E++ ++Q +++ + D
Sbjct: 255 ELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDE 314
Query: 89 CRLMKEKLEEEENLTRELKSEIERL------QKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
++EK E L EL E+L + RM EL + +K + +
Sbjct: 315 LDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAAR 374
Query: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
+ ++ E L+ K+ +LE D K + L E L+ +++++ +NE
Sbjct: 375 ARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLE------IAQKQSMNE 428
Query: 203 KEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED--GISSTLPSKESRRKGG 260
+L ++L +N ++ D +R + E N+ + S +S +G
Sbjct: 429 SAHLGWEL-----EQLSKNADLS-DASRKSFVFELNECASSRILKLEKENQSLQSTIQGL 482
Query: 261 LDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSK-N 319
D +E E EK +Q K++ L ++E+ K + E+L EEL + K +
Sbjct: 483 RDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQ 542
Query: 320 NDLQDNYLSEQNKNKLLASQLEEIK--LQIKKQKELENGEVEGEDAFLSSKGRHER-TKF 376
+D++ + + K L + + + + +++ + E +D +K H+ T+
Sbjct: 543 SDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEA 602
Query: 377 RGHGSEASVSKHTARELSPQHKR-----ERLRNREFALNNENYSLSNRQVSSPSFTNRRA 431
G S+ K Q K E+L L EN L+ R+V+S +
Sbjct: 603 NGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLA-RKVTSLETATEKV 661
Query: 432 AKASHMGVSTDSGTQETKKTEDRFVPGSSQSEG 464
H + +K+ D S Q EG
Sbjct: 662 EALEHESQGLQLENRTLRKSLDTLQNVSLQLEG 694
Score = 53.1 bits (126), Expect = 1e-06
Identities = 100/478 (20%), Positives = 207/478 (43%), Gaps = 41/478 (8%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQ-----DKVIQAEGSNSSMLAEIEVLRQ 70
L +L + R D++ E K + + +L DL+ DK E +M+ EI +
Sbjct: 366 LEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQS 425
Query: 71 --RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTR-----ELKSEIERLQKRMAELEKL 123
+ + E++ + DL ++ E N +L+ E + LQ + L
Sbjct: 426 MNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDA 485
Query: 124 EEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASEL 183
S C +L ++ +K+ ++LE + ++LE+ + L + ++ L S++
Sbjct: 486 SLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDM 545
Query: 184 EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLER---NDL 240
E LK+ + + + + E+E + L + + E+++ + ++ + +
Sbjct: 546 ETLKA------DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTV 599
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
+G S L ++ + L+ K+ + E K E E R QE+N L +++ L+T
Sbjct: 600 TEANGKLSQLEFEKRQLHRDLEQAKE-KGERAEKLERELQRLQEEN--GRLARKVTSLET 656
Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE- 359
+ E+LE E + ++ +N L+ + + QN ++ QLE ++ + KQ + EN E+
Sbjct: 657 ATEKVEALEHESQGLQLENRTLRKSLDTLQN----VSLQLEGLE-RDNKQLDAENLELRR 711
Query: 360 --GEDAFLSSK-GRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSL 416
F S+K + ER + + + K+ + K ERL +++ EN L
Sbjct: 712 LVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRL 771
Query: 417 SNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEG----KKSREQ 470
Q S S +++ S +G ++ Q ++ + ++Q EG +K+ EQ
Sbjct: 772 ---QQSLESSSHKTQTLESELG-ELEAERQALRRDLEALRLANAQLEGAEKDRKALEQ 825
Score = 49.3 bits (116), Expect = 2e-05
Identities = 116/594 (19%), Positives = 223/594 (37%), Gaps = 70/594 (11%)
Query: 41 EDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEE 100
E E LQ + Q + ++L + E L R + E + R + + LE E
Sbjct: 1147 ETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEH 1206
Query: 101 NLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV 160
+EL + KR AELE+ E+ + + +L +E+ E + LR
Sbjct: 1207 ---KELGERHGDMLKRKAELEEREKVLTTERE-------ALQQEQRTNALAMGENQRLRG 1256
Query: 161 KVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQ 220
++ DR++ L E E+L + T + LN + E + + EQ
Sbjct: 1257 EL-------DRVNFLHHQLKGEYEELHAHTKELKTS---LNNAQLELNRWQARFDELKEQ 1306
Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN 280
++ M+ T+ ++ E + + L + + L Q +N+ E+N
Sbjct: 1307 HQTMDISLTKLDNHCE-----LLSRLKGNLEEENHHLLSQIQLLSQ-----QNQMLLEQN 1356
Query: 281 RNQEDNKVKDLNQEIEKLKTQIKHFESLEEELK---KMKSKNNDLQDNYLSEQNKNKLLA 337
++ ++ Q I+KL +H E LEE++ K +++++ + KL+
Sbjct: 1357 MENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIK 1416
Query: 338 SQLEEIKLQIKKQKELENGEVEGEDAF-------LSSKGRHERTKFRGHGSEASVSKHTA 390
+ E + ++K + ++E D L S+ + T G H
Sbjct: 1417 PKKEGSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPALGSNCAEERDAHNG 1476
Query: 391 R------ELSPQ----HKRERLR---NREFALNNENYSLSNRQVSSPSFTNRRAAKASHM 437
+L P+ H+ R + + A+ + L +R S+ + T A ++
Sbjct: 1477 SVGKGPGDLKPKRGSPHRGSLDRTDASTDLAMRSWPSELGSRTCSTSATT---TAPSNST 1533
Query: 438 GVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTE 497
++ G + ++D S + E R+ S P++ E S + TS +
Sbjct: 1534 PIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQYVS-----RPSSLESS---RNTSSNSSP 1585
Query: 498 SGLKGKVEKT-TRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAA 556
LKG E+ R+ S ++ +PS L + + T G+ + L + Q
Sbjct: 1586 LNLKGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEG 1645
Query: 557 NSGCSKA---IGALASSRRSSSE--GLSKGKKAANGLEADNSCPNSKAPVLSKY 605
A +G S SSE L + + +N + P+ + +LS Y
Sbjct: 1646 AQKRGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDY 1699
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 78.2 bits (191), Expect = 4e-14
Identities = 86/415 (20%), Positives = 178/415 (42%), Gaps = 39/415 (9%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
K+ + L LQ ++ E L + E+ L LQD Q +G + ++E
Sbjct: 358 KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLET 417
Query: 68 LRQRVLRIEGKDE---------EIKRAEDLCRLMKEK--LEEEE----NLTRELKSEIER 112
L+Q + + E +R + +L+ E+ EEE+ +L +L+S I
Sbjct: 418 LKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477
Query: 113 LQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRL 172
L + ELE+ +A + +LT ++++ ++ + +EL + +
Sbjct: 478 LSQAKEELEQASQAHGARLT---------AQVASLTSELTTLNATIQQQDQELAGLKQQA 528
Query: 173 DKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA 232
+ + LA L++ + + + + L+ K+ E+ +KE+ +K E ++ + A
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 233 SNLERNDLRIEDGISSTLPSKESRRKGGLDYLK---QVENETRNKSENEKNRNQEDNKVK 289
+ LR D L + E + L+ L+ QV NE R+ ++ + Q +
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK--A 646
Query: 290 DLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNK---NKLLASQLEEIKLQ 346
+L++++E+L+ + E+ +E + +++ +L+ SEQ K + +A + ++++ Q
Sbjct: 647 ELSRKVEELQACV---ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 347 IKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRER 401
++ KE ++ L + R S K R L QHKRER
Sbjct: 704 LQALKE----SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754
Score = 59.3 bits (142), Expect = 2e-08
Identities = 127/588 (21%), Positives = 232/588 (39%), Gaps = 91/588 (15%)
Query: 15 HLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQ-AEGSNS---SMLAEIEVLRQ 70
H + L S R L ++ KAEDE + Q AE NS S+ E+ +L +
Sbjct: 1180 HSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNR 1239
Query: 71 RVLRIEGKDEEIKR-----------AEDLCRLMK---------------------EKLEE 98
+VL EG+ +E+KR E+ RL++ + L E
Sbjct: 1240 QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299
Query: 99 E--------ENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKK 150
E ENL +EL S+ ER ++ EL+ +E F + + Q +L E T+
Sbjct: 1300 EAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE----QALSTLQLEHTSTQA 1355
Query: 151 ISSELEMLRVKVKELESSE--------DRLDKTEQS---LASELEKLKSLTLSFVSERKY 199
+ SEL + ++L++ + + L++++Q+ L +EL + + + R+
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415
Query: 200 LNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA---------SNLERNDLRIE--DGISS 248
+ E+E+ ++L E EQ + + + A +NL R L +E
Sbjct: 1416 VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREK 1475
Query: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEK--NRNQEDNKVKDL------NQEIEKLKT 300
+ + R L +V+ E ++ + + E KVK L +E +KL
Sbjct: 1476 YVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1535
Query: 301 QIKHFESLE-EELKKMKSKNNDLQD-NYLSEQNKNKLLASQLEEIKLQIKKQK-ELENGE 357
Q++ E + E+ K+++ + L D + S+ + KL A Q + + Q + Q+ + + E
Sbjct: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE 1595
Query: 358 VEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLS 417
++ + + H + + E + + + A++ Q +E+LR+ E L EN L
Sbjct: 1596 LQAQLSQKEQAAEHYKLQM-----EKAKTHYDAKKQQNQELQEQLRSLE-QLQKENKELR 1649
Query: 418 NRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSE--GKKSREQPSVLS 475
+ K + T + + E + Q GK ++ S
Sbjct: 1650 AEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKS 1709
Query: 476 RYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDP 523
R P A + + E K RT D T SVP +P
Sbjct: 1710 REPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGT--SVPGEP 1755
Score = 56.2 bits (134), Expect = 2e-07
Identities = 82/366 (22%), Positives = 144/366 (39%), Gaps = 57/366 (15%)
Query: 66 EVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKR--------- 116
E L + EGKD+E+ + L ++LEE ++LK ++ + +K
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 117 ----------------MAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRV 160
AE+ KLE+ + + L SL ER + S LE L+
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ- 1168
Query: 161 KVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQ 220
+LE L ++ +LAS +L +F ++ + ++ E E + + Q+ E+
Sbjct: 1169 --GQLEEKAQELGHSQSALASAQREL----AAFRTKVQDHSKAEDEWKAQVARGRQEAER 1222
Query: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKN 280
+ S L R L E SKE +R L E+E K E E+
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEG------ESKELKR------LVMAESEKSQKLE-ERL 1269
Query: 281 RNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQL 340
R + + + E+ + +SL EE +K + + +L+ S+ A +
Sbjct: 1270 RLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ-------AERA 1322
Query: 341 EEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRE 400
EE+ ++K +E + E A S + E T + SE +KH ++L +
Sbjct: 1323 EELGQELKAWQE---KFFQKEQAL--STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377
Query: 401 RLRNRE 406
R+RE
Sbjct: 1378 EKRHRE 1383
Score = 54.3 bits (129), Expect = 6e-07
Identities = 102/483 (21%), Positives = 185/483 (38%), Gaps = 75/483 (15%)
Query: 22 SLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEE 81
+L+R L +++E QK D+L LQ+K+ + S +A +E L +R G+ +E
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKM----AATSKEVARLETL----VRKAGEQQE 931
Query: 82 ------IKRAEDLCRLMKEKLEEEEN----LTRELKSEIERLQKRMA-ELEKLEEAFSRS 130
+K E LEE++ T+ +ER ++M ELE+L A S
Sbjct: 932 TASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMES 991
Query: 131 -------KNDCTQLCLSLNEERN-------LTKKISSELEM------------------- 157
+ + L +ER L K +ELEM
Sbjct: 992 QGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA 1051
Query: 158 LRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEK---LIKEL 214
L + E E + L K A+++++L+ L + ++ L +KEKE+ E
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 215 TQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK 274
+ E S LE+ + ++ S S E+ R + +E
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171
Query: 275 SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK 334
E + + + +E+ +T+++ E+E K ++ + KN
Sbjct: 1172 EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ------EAERKNS 1225
Query: 335 LLASQLEEIKLQIKK--QKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARE 392
L++S EE+ + ++ +KE E+ E++ S K + + R +E + + A E
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Query: 393 LSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTE 452
S + E RE A S + RQ +A +A +G QE K +
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQE-----LTSQAERAEELG-------QELKAWQ 1333
Query: 453 DRF 455
++F
Sbjct: 1334 EKF 1336
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/382 (20%), Positives = 158/382 (41%), Gaps = 47/382 (12%)
Query: 39 KAEDELLDLQDKVIQAEGSN------SSMLAEI---EVLRQRVLRIEGKDEEIKRAEDLC 89
K E L+LQ + G+N +S + +I + R L+ + DE R E
Sbjct: 176 KREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDE--- 232
Query: 90 RLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTK 149
++ +L E L E ++I +Q+R+ L L E + S + +L ++ +LT
Sbjct: 233 --LELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290
Query: 150 KISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYL----NEKEK 205
++ L+ + ++L++ + ++D+ L+ E L F S + L NE +
Sbjct: 291 RLHETLK----QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTE 346
Query: 206 ENEKLIKELTQKLEQ-NKKMNRDYTRNASNLERNDL------RIEDGISSTLPSKESRRK 258
E+ K +E +K Q K+++ E+N++ ++E+ +S + +
Sbjct: 347 EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406
Query: 259 GGLDYLKQVENETRNKSENEKNRNQEDNKVKDL----NQEIEKLKTQIKHFESLEEELKK 314
L + Q+E + + N Q +V+ L Q+ KL + HF EEE ++
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF---EEEKQQ 463
Query: 315 MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
+ S DLQ + S L + K ++++ + + + A L+S+
Sbjct: 464 LSSLITDLQSS-----------ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512
Query: 375 KFRGHGSEASVSKHTARELSPQ 396
+ E + K A+E Q
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQ 534
Score = 50.4 bits (119), Expect = 9e-06
Identities = 126/575 (21%), Positives = 217/575 (37%), Gaps = 101/575 (17%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKA-EDELLDLQDKVIQAEGSNSSMLAEIE 66
K T R + K Q L +L L+E+ K + + E+E D + + + S + AE
Sbjct: 686 KATEKERVAQEKDQ-LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 67 VLRQRVLRIEGKDEEIKRA------EDLCRLMKEKLEEEENLTREL----------KSEI 110
L ++ R E K+ E +RA L +L + E E L REL +SE
Sbjct: 745 SLVEQHKR-ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESEC 803
Query: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTK----KISSELEMLRVKVKELE 166
E+L K +A E + S+ + Q E+ K K EL+ + KV +E
Sbjct: 804 EQLVKEVAAWR---ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
Query: 167 SSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEK---------------EKENEKLI 211
S + +Q+ +EL + L V E++ +K KE +L
Sbjct: 861 SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Query: 212 KELTQKLEQNKKMNRDYTRNASNL-ERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
+ + EQ + +R+ + + +R +E+ S ++ + +Q+ NE
Sbjct: 921 TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980
Query: 271 --------TRNKSENEKNRNQEDNKVKDLNQE---------IEK-------------LKT 300
++ + ++ R Q++ +V L QE +EK L
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKE----LENG 356
Q F +L+E L ++ + +LEE++ +K+ KE E
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100
Query: 357 EVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSL 416
G A + GR E T + A VSK E Q ++E+ + E +L E S
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSK---LEQQCQKQQEQADSLERSLEAERASR 1157
Query: 417 SNRQVSSPSFTNRRAAKASHMGVSTD-------------SGTQETKKTEDRF----VPGS 459
+ R + + + KA +G S + Q+ K ED + G
Sbjct: 1158 AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR 1217
Query: 460 SQSEGKKS-----REQPSVLSRYPPAAQEHSKAWK 489
++E K S E+ S+L+R + SK K
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELK 1252
Score = 42.0 bits (97), Expect = 0.003
Identities = 85/455 (18%), Positives = 189/455 (41%), Gaps = 56/455 (12%)
Query: 3 EFTSYKETASSR--HLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
E + + A +R ++ + QS +R ELE T + A+ ++L+ + + + ++
Sbjct: 1479 ELAAVRADAETRLAEVQREAQSTAR---ELEVMTAKYEGAKVKVLEERQRFQEERQKLTA 1535
Query: 61 MLAEIEVL-RQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAE 119
+ ++EV R++ ++E +++ ++ ++ ++KL+ + E + E +RLQ +
Sbjct: 1536 QVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ--- 1592
Query: 120 LEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSL 179
L +L+ S+ + L + + + + + L+ +++ LE +L K + L
Sbjct: 1593 LNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE----QLQKENKEL 1648
Query: 180 ASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERND 239
+E E+L E + K KE E+ + LT ++ + + +L +
Sbjct: 1649 RAEAERLG-------HELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQ 1701
Query: 240 LRIEDGISSTLPSKESRRKGGLDYLK-QVENETRNKSENEKNRNQEDNKV---KDLNQEI 295
+ D + S P + + +D L E T ++ R Q D + +
Sbjct: 1702 V-ATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPIS 1760
Query: 296 EKLKTQIKHFESL------EEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKK 349
++L +++ ESL ++S + L D +L K + + +I + I
Sbjct: 1761 QRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQI-INITM 1819
Query: 350 QKELENGEVE-GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
K+L+ E + +F S++ A S+ + R S RL + ++
Sbjct: 1820 TKKLDVEEPDSANSSFYSTR-------------SAPASQASLRATSSTQSLARLGSPDYG 1866
Query: 409 LNNENYSLSNRQVSSPSF--TNRRAAKASHMGVST 441
++ +S P + T R +A+ S GVS+
Sbjct: 1867 --------NSALLSLPGYRPTTRSSARRSQAGVSS 1893
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 77.8 bits (190), Expect = 5e-14
Identities = 83/395 (21%), Positives = 184/395 (46%), Gaps = 64/395 (16%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKA----EDELLDLQDKV--IQAEGSNSSM 61
K ++ + L+F+L+ ++ L L+ ++L++ + E ++Q K+ ++ G +
Sbjct: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
Query: 62 LAEIE----VLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERL---- 113
+ E+E ++++ V +++ ++E++K+A + L EK+ E +LK+E+E+L
Sbjct: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGI--LTSEKMANIEQENEKLKAELEKLKAHL 2184
Query: 114 ---------------QKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEML 158
+K +AE E+L + + + +L ++ N L +K++ +LE
Sbjct: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET 2244
Query: 159 RVKVKELESSEDRLDKTEQSLASEL-------EKLKSLTLSFVSERKYLNEKEKENEKLI 211
+++ ES +L+ + + KLK L + N+ + ++L+
Sbjct: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK----NQSITDLKQLV 2300
Query: 212 KELTQKLEQNKKMNRDYTRNASNLER--NDLRIEDGISSTLP----SKESRRKGGLDYLK 265
KE T++ ++ K N D + L+ E G+ L + K + +
Sbjct: 2301 KEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIH 2360
Query: 266 QVE-NETRNKSENE-KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMK------- 316
Q+E N+ ++ +E+ + +Q K+KDL +++ + +H L+EE+KK+K
Sbjct: 2361 QIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH---LKEEIKKLKKELENFD 2417
Query: 317 ----SKNNDLQDNYLSEQNKNKLLASQLEEIKLQI 347
+ DL+ NY E KN LL +++++ Q+
Sbjct: 2418 PSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Score = 72.0 bits (175), Expect = 3e-12
Identities = 94/428 (21%), Positives = 187/428 (43%), Gaps = 55/428 (12%)
Query: 29 ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLA---EIEVLRQRVLRIEGK-----DE 80
EL EA K L+ E + L+D V++ + + + EIE+L + + ++E K DE
Sbjct: 440 ELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDE 499
Query: 81 ----------EIKRAEDLCRLMKEKLEEEENLTRE---LKSEIERLQKRMAELEKLEEAF 127
E K DL K +++ E L EIE L++ +L+K
Sbjct: 500 NEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM 559
Query: 128 SRSKNDCTQLCLSLNEERNLTKKISS-------ELEMLRVK-VKELESSEDRLDKTEQSL 179
++ + + E+ NLT+ IS +L++L +K + E +S + L +
Sbjct: 560 AQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK 619
Query: 180 ASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERND 239
+LE+ +++ F ++ K L E+ K+ E+ +KE+ Q +++ +K + D ++L
Sbjct: 620 ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQK-DPDVKGGETSLIIPS 678
Query: 240 L-RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKL 298
L R+ + I S + E L QV+ T E + + + + +Q++ K
Sbjct: 679 LERLVNAIES--KNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736
Query: 299 KTQIKHFESLEEELKKMKSKN-----NDLQDNYLSE-----QNKNKLLASQLEEIKLQIK 348
+I H E L++ + N DL D ++N+ L L+E++ + K
Sbjct: 737 NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK 796
Query: 349 KQKELEN---------GEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKR 399
K K LE+ + + + L + E+ ++ +E+ K R+L Q ++
Sbjct: 797 KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWK---TESKTIKEEKRKLEDQVQQ 853
Query: 400 ERLRNREF 407
+ ++ +E+
Sbjct: 854 DAIKVKEY 861
Score = 68.6 bits (166), Expect = 3e-11
Identities = 110/499 (22%), Positives = 214/499 (42%), Gaps = 84/499 (16%)
Query: 13 SRHLRFKLQSLSRRLD----ELEEATKNLQKAE--DELLDLQDKVIQAEGSNSSMLAE-- 64
+R LR ++ L ++L+ ELE+ K L+K + +E L L+++ +AE NS + E
Sbjct: 110 TRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE--EAENENSKLRRENK 167
Query: 65 -------------------IEVLRQRVLRIEGKDEEI-----KRAEDLCRLM-------- 92
I+ ++ +L G+D + K+ +L + +
Sbjct: 168 RLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE 227
Query: 93 -KEKLE-EEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQL-------CLSLNE 143
EK+E + + + + L+ ++ ++K E +++ ++ N QL L + E
Sbjct: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQE 287
Query: 144 ERNLTKKISSELEMLRV----KVKE----LESSEDRLDKTEQSLASELEKLKSLTL-SFV 194
+L K + E + + V KV+E L S +D + + +Q L + EKLK+ L +
Sbjct: 288 LTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADK 347
Query: 195 SERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKE 254
S L + +E + IK LT+++EQ K T +L +N+L+ G S+
Sbjct: 348 SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDL-KNELQRNKGASTLSQQTH 406
Query: 255 SRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKK 314
+ + LD LK+ E +E + +E K K+L + +++LK LE+ + +
Sbjct: 407 MKIQSTLDILKEKTKEAERTAELAEADARE--KDKELVEALKRLKDYESGVYGLEDAVVE 464
Query: 315 MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERT 374
+K+ N ++ + ++L ++ KL++K L+ E E L K + T
Sbjct: 465 IKNCKNQIK----IRDREIEILTKEIN--KLELKISDFLDENEALRERVGLEPKTMIDLT 518
Query: 375 KFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKA 434
+FR SKH K+++ R L E SL ++ + A +
Sbjct: 519 EFRN-------SKHL--------KQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
Query: 435 SHMGVSTDSGTQETKKTED 453
++ T++ TE+
Sbjct: 564 GKRSATSGLTTEDLNLTEN 582
Score = 64.7 bits (156), Expect = 4e-10
Identities = 97/439 (22%), Positives = 189/439 (43%), Gaps = 49/439 (11%)
Query: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATK-NLQKAEDELLDLQDKVIQAEGSNSSM 61
E T ++ S L KL+ +S+ L+ E T+ +++ E+ L LQ+ E +
Sbjct: 1627 EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQEN---HEDEVKKV 1683
Query: 62 LAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELE 121
AE+E L+ +L K+ + ++E L +K T +++ +ERL+ ++A E
Sbjct: 1684 KAEVEDLKY-LLDQSQKESQCLKSE----LQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
Query: 122 KLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEM---------LRVKVKELESSEDRL 172
K ++A SR+ + + EER ++ E + R ++E + L
Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
Query: 173 DKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNA 232
K +++L + + SLT + L +K+K K+++E + ++N ++ R R
Sbjct: 1799 LKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLT 1858
Query: 233 SNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSE-------NEKNRNQE- 284
S L+ L D S + +E +RK +K++EN+ K E EKN +E
Sbjct: 1859 SGLQGKPL--TDNKQSLI--EELQRK-----VKKLENQLEGKVEEVDLKPMKEKNAKEEL 1909
Query: 285 --DNKVKDLNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
+ K +IE ++ ++K E +L ++L +K L+ Q K K
Sbjct: 1910 IRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGM 1969
Query: 339 QLEEIK--LQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQ 396
++++ ++ +KELE + D ++ R H + S L +
Sbjct: 1970 TVDQVLGIRALESEKELEELKKRNLDL------ENDILYMRAHQALPRDSVVEDLHLQNR 2023
Query: 397 HKRERLRNREFALNNENYS 415
+ +E+L E + + YS
Sbjct: 2024 YLQEKLHALEKQFSKDTYS 2042
Score = 57.0 bits (136), Expect = 9e-08
Identities = 103/468 (22%), Positives = 192/468 (41%), Gaps = 66/468 (14%)
Query: 3 EFTSYKETASSRHL---RFKLQSLSRRLDELEEATKNLQKAEDELLDL---QDKVIQAEG 56
EF S + R L R + +L EL E K L++ E+L K +G
Sbjct: 610 EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKG 669
Query: 57 SNSSMLAEIEVLRQRVLRIEGKDEE----------------IKRAEDLCRLMKEKLEEEE 100
+S++ I L + V IE K+ E R E+L + ++E +E
Sbjct: 670 GETSLI--IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 727
Query: 101 NLTRELKS---EIERLQKRMAELEKLE------EAFSRSKNDCTQLCLSLNEERNLTKKI 151
N +++L +I+ L+K + L + E + +N + +
Sbjct: 728 NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 787
Query: 152 SSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKE--KENEK 209
ELE K K+L++ ED L+ + A + +SL ++YL+EKE K K
Sbjct: 788 LQELEN---KEKKLKNLEDSLEDYNRKFA-VIRHQQSLLY-----KEYLSEKETWKTESK 838
Query: 210 LIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGL-------- 261
IKE +KLE + + + +NL N L+++ + ++ SR+ L
Sbjct: 839 TIKEEKRKLEDQVQQDAIKVKEYNNL-LNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
Query: 262 -DYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNN 320
Y VE E + + ENEK +N+ + ++ ++I L+ + L+K+ +
Sbjct: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
Query: 321 DLQDNYLSEQNKNKLLASQ---LEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFR 377
L + L+ + N+L A L++ + +++ LE+ E E +S K + E
Sbjct: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECEN----ISLKEQVESI--- 1010
Query: 378 GHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPS 425
E ++K + ++E E +++ S++N + S S
Sbjct: 1011 --NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSIS 1056
Score = 54.3 bits (129), Expect = 6e-07
Identities = 101/467 (21%), Positives = 189/467 (40%), Gaps = 84/467 (17%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
++ K Q + L+E+E+A + K E++L + KV++ E E+E+ +Q
Sbjct: 59 MKMKAQEVELALEEVEKAGEEQAKFENQL---KTKVMKLEN-------ELEMAQQSA--- 105
Query: 76 EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
G+D R E +C+L K+ L+++ ELE +E+ + K
Sbjct: 106 GGRDTRFLRNE-ICQLEKQ------------------LEQKDRELEDMEKELEKEKKVNE 146
Query: 136 QLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVS 195
QL L E N K+ E + L+ K ++L +D +D +Q + S+ E L S
Sbjct: 147 QLALRNEEAENENSKLRRENKRLKKKNEQL--CQDIIDYQKQ-IDSQKETLLSRRGEDSD 203
Query: 196 ERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKES 255
R L++K E + + E+ E N+K+ NLE +
Sbjct: 204 YRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES----------------- 246
Query: 256 RRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKM 315
++++E T + + +Q DN I++LK + H++ +EL +
Sbjct: 247 --------VQEMEKMTDEYNRMKAIVHQTDNV-------IDQLKKENDHYQLQVQELTDL 291
Query: 316 KSKNNDLQDNYLSEQNK-----NKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
N+ D + N +L+S+ +EI I+ Q+ L N + ++A L +
Sbjct: 292 LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEI---IEYQQMLHNLREKLKNAQLDADKS 348
Query: 371 HERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRR 430
+ +G S K ++ Q+ +E +N + +N N+ S+ S
Sbjct: 349 NVMALQQGIQERDSQIKMLTEQVE-QYTKEMEKNTCIIEDLKNELQRNKGASTLS----- 402
Query: 431 AAKASHMGV-STDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSR 476
+ +HM + ST +E K +R + +K +E L R
Sbjct: 403 --QQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKR 447
Score = 52.4 bits (124), Expect = 2e-06
Identities = 80/402 (19%), Positives = 180/402 (44%), Gaps = 45/402 (11%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
L+ +++S+++ L+ +E +++A ++ L ++ + S ++I + +++ +
Sbjct: 1003 LKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITML 1062
Query: 76 EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
E K+ ++ + C+ M E L++ ++++++R ELE ++ D
Sbjct: 1063 EMKELNERQRAEHCQKMYE----------HLRTSLKQMEERNFELETKFAELTKINLDAQ 1112
Query: 136 QLCLSLNEER--NLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
++ L +E +++K +S + R ++ ELE K E L E+ KL+ ++
Sbjct: 1113 KVEQMLRDELADSVSKAVS---DADRQRILELE-------KNEMELKVEVSKLREISDIA 1162
Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERN-DLRIEDGIS-STLP 251
+ + LN +++ +K ++ L +L + + + + A + N L++ + + L
Sbjct: 1163 RRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLE 1222
Query: 252 SKESRRKGGLDYLKQVENETRNKSEN-EKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEE 310
S S+ + Y ++E + K + R + N+ K L Q I+ L+ Q L +
Sbjct: 1223 SITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQ 1282
Query: 311 ELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR 370
+ K K+ + + +KL ++E+K ++ + +EN +E E L KG
Sbjct: 1283 QEKFSKT---------MIQLQNDKL--KIMQEMKNSQQEHRNMENKTLEME---LKLKGL 1328
Query: 371 HERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNE 412
E S +K + ++ K E LR +E LN E
Sbjct: 1329 EELI------STLKDTKGAQKVINWHMKIEELRLQELKLNRE 1364
Score = 50.8 bits (120), Expect = 7e-06
Identities = 91/396 (22%), Positives = 170/396 (42%), Gaps = 52/396 (13%)
Query: 17 RFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIE 76
R +SL +L E E A L+ AE +L +DKVI AE E L + R E
Sbjct: 1471 RATCKSLEEKLKEKESA---LRLAEQNILS-RDKVINELRLRLPATAEREKLIAELGRKE 1526
Query: 77 GKDEE---IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK----------- 122
+ + +K A M+ +L ++E + ++ + +E+ ++ E+ K
Sbjct: 1527 MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHH 1586
Query: 123 -LEEAFSRSKNDCTQLCLSLNEERNL---TKKISSELEMLRVKVKELESSEDRLDKTEQS 178
LE S N Q L ++ T K L + V E + S L +
Sbjct: 1587 RLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646
Query: 179 LASELEKLKSLTLSFVSERKYLNEKEKEN-EKLIKELTQKLEQNKKMNRDYTRNASNLER 237
++ +LE+ + +T V E + + + +EN E +K++ ++E K + D ++ S +
Sbjct: 1647 VSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYL-LDQSQKESQCLK 1705
Query: 238 NDLRIEDGISSTLPS----------------KESRRKGGLDYLKQVENETRNKSENE--- 278
++L+ + +S P+ KE ++K L ++ E +E
Sbjct: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
Query: 279 --KNRNQEDNKVKDLNQEIEKLKTQIKHFE----SLEEELKKMKSKNNDLQDNYLSEQNK 332
+ N + +++ +LKTQ++ L+E LK K++ N L DN L++ N
Sbjct: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDN-LNDLN- 1823
Query: 333 NKLLASQLEEIK-LQIKKQKELENGEVEGEDAFLSS 367
N+L Q K L+ K++ + EN E++ + L+S
Sbjct: 1824 NELQKKQKAYNKILREKEEIDQENDELKRQIKRLTS 1859
Score = 50.4 bits (119), Expect = 9e-06
Identities = 77/399 (19%), Positives = 163/399 (40%), Gaps = 82/399 (20%)
Query: 27 LDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAE 86
+D+L++ + Q EL DL + E + M+A + + L + KD+EI +
Sbjct: 271 IDQLKKENDHYQLQVQELTDLLKS--KNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ 328
Query: 87 DLCRLMKEKL------------------------------EEEENLTRELKSEIERLQKR 116
+ ++EKL E+ E T+E ++K
Sbjct: 329 QMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKE-------MEKN 381
Query: 117 MAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLD--- 173
+E L+ R+K T L+++ ++ KI S L++L+ K KE E + + +
Sbjct: 382 TCIIEDLKNELQRNKGAST-----LSQQTHM--KIQSTLDILKEKTKEAERTAELAEADA 434
Query: 174 -KTEQSLASELEKLK----------SLTLSFVSERKYLNEKEKENEKLIKELTQK----- 217
+ ++ L L++LK + + + + +++E E L KE+ +
Sbjct: 435 REKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS 494
Query: 218 --LEQNKKMNR----------DYT--RNASNLERNDLRIEDGI-SSTLPSKESRRKGGLD 262
L++N+ + D T RN+ +L++ R E+ I + S E R
Sbjct: 495 DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKK 554
Query: 263 YLKQVENETRNKSENEKNRNQEDNKVKDLNQ--EIEKLKTQIKHFESLEEELKKMKSKNN 320
++Q+ E +S ++ N ++++Q I + K + +++ E K + +
Sbjct: 555 KIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSR 614
Query: 321 DLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
+L + + ++A ++K +++ K+LE G E
Sbjct: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKE 653
Score = 46.2 bits (108), Expect = 2e-04
Identities = 80/346 (23%), Positives = 146/346 (42%), Gaps = 69/346 (19%)
Query: 29 ELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLR-IEGKDEEIKRAED 87
+LE + ++E+L+ K +A GS + + LR I+ I
Sbjct: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472
Query: 88 LCRLMKEKLEEEENLTRELKSE-------IERLQKRM---AELEKLEEAFSRSKND---- 133
C+ ++EKL+E+E+ R + I L+ R+ AE EKL R + +
Sbjct: 1473 TCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSH 1532
Query: 134 ---------CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELE 184
+ LN++ + KK LE R + +E+ + K E+ L
Sbjct: 1533 HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREI------VKKHEEDLHILHH 1586
Query: 185 KLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
+L+ + LN+ ++ L+K+ + NK R + +E+ +D
Sbjct: 1587 RLE------LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR-----LAEMEQTVAEQDD 1635
Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKH 304
+SS L LK+V + E+ R + KVK E E +K Q++
Sbjct: 1636 SLSSLLVK-----------LKKVSQDL------ERQREITELKVK----EFENIKLQLQ- 1673
Query: 305 FESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQ 350
E+ E+E+KK+K++ DL+ YL +Q++ + SQ + +LQ +K+
Sbjct: 1674 -ENHEDEVKKVKAEVEDLK--YLLDQSQKE---SQCLKSELQAQKE 1713
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 77.8 bits (190), Expect = 5e-14
Identities = 93/504 (18%), Positives = 219/504 (43%), Gaps = 50/504 (9%)
Query: 7 YKETASSRHLRFKLQSLSRRLD-----------ELEEATKNLQKAEDELLDLQDKVIQAE 55
Y+ T ++ L+ K L +L ++E + L++A+ L +Q +Q E
Sbjct: 214 YRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEE 273
Query: 56 GSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQK 115
M + E LR++ +I ++E++ R E+ R + K+ E+E ++ R +K
Sbjct: 274 -----MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE-------EKMWRQEK 321
Query: 116 RMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT 175
R+ E EK + + +L + + +K+ + E +R + +++ E+RL +
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 176 EQSLASELEKLKSLTLSFVSERKYLNEKE---KENEKLIKELTQKLEQNKKMNRD--YTR 230
E+ + + +K++ + + L EKE +E EK+ +++ +K+ + KKM TR
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV-EKMREEKKMQEQEKKTR 440
Query: 231 NASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKD 290
+ + + RI + +E + + + +++ E + + + EN + +++ + +
Sbjct: 441 DQEEKMQEEERIRE--------REKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQN--KNKLLASQLEEIKLQIK 348
L ++ EKL Q K + EE++ + + K D ++ + E+ + + + Q +++ Q +
Sbjct: 493 LPEQKEKLWEQEK-MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
K ++ E + E+ E+ + + RE + + E +R +E
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 409 LNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDS-GTQETKKTEDRFVPGSSQS--EGK 465
+ + + ++ + + M + QE K E + +P + E +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 466 KSREQPSVLSRYPPAAQEHSKAWK 489
K +EQ + ++ K W+
Sbjct: 672 KMQEQEKM-------QEQEEKIWE 688
Score = 75.5 bits (184), Expect = 3e-13
Identities = 99/537 (18%), Positives = 211/537 (39%), Gaps = 55/537 (10%)
Query: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEV 67
++ R K+ +RL E E+ + +K E +L+++ Q + M + E
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
Query: 68 LRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
+R++ ++ ++E + E R ++K+ ++E E + ++RM E EK+ E
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
Query: 128 SRSK------------NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKT 175
+ + D + R KK+ E E +R + ++++ E+ + +
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 176 E------QSLASELEKLKSLTLSFVSERKYLNEKEK---------------ENEKLIKEL 214
E Q L + EKL E K ++EK EK+ ++
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 215 TQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNK 274
Q EQ +KM + ER + + ++ T +E R + + E E + +
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR----EEERMREREKKMR 599
Query: 275 SENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNK 334
E E R QE+ + ++ EK++ Q + EE++++ + K + ++ ++ K
Sbjct: 600 EEEEMMREQEEK----MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK-- 653
Query: 335 LLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGR-HERTKFRGHGSEASVSKHTAREL 393
E+ +L +K+K E+ +++ ++ + + E+ K E + +
Sbjct: 654 ----MWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE---QEKKTWDQ 706
Query: 394 SPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDS-GTQETKKTE 452
+ E +R RE + E + ++ + + M + QE K E
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 453 DRFVPGSSQS--EGKKSREQPSVLSRYPPAA-QEHSKAWKGTSKPGTESGLKGKVEK 506
+ +P + E +K +EQ + + QE + G E ++G+ EK
Sbjct: 767 QQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823
Score = 62.0 bits (149), Expect = 3e-09
Identities = 62/307 (20%), Positives = 140/307 (45%), Gaps = 18/307 (5%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRI 75
+R + + + + + E + +Q+ E+++ + ++K+ + E ++ +++
Sbjct: 591 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 76 EGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCT 135
E K E +R + KEKL E E + + K ++ ++++ E EK+E+ +
Sbjct: 651 EEKMWEQQRLPE----QKEKLWEHEKMQEQEK--MQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 136 QLCLSLNEE--RNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
EE R KK+ E EM+R + ++++ E+++ + E+ + + EK+
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Query: 194 VSERKYLNEKEK--ENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLP 251
+++ +KEK E+EK+ +E + EQ +KM R+ R G +
Sbjct: 765 WEQQRLPEQKEKLWEHEKM-QEQEKIWEQEEKM-----RDQEEKMRGQEEKMRGQEEKMR 818
Query: 252 SKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEE 311
+E + G + K E + + EK QE+ + + + EK++ Q + EE+
Sbjct: 819 GQEEKMWGQEE--KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876
Query: 312 LKKMKSK 318
+++ + K
Sbjct: 877 MREQEEK 883
Score = 55.8 bits (133), Expect = 2e-07
Identities = 65/300 (21%), Positives = 134/300 (44%), Gaps = 31/300 (10%)
Query: 80 EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRM--AELEKLEEAFS----RSKND 133
EE+ + D L +L ELK + LQ+++ AE EK E + + K +
Sbjct: 200 EELTKERDALSL---ELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256
Query: 134 CTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSF 193
+ L + L +++ + E LR + K++ E+++ + E+ L + K++
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316
Query: 194 VSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSK 253
+ K L E+EKE + KEL ++ E ++ + + E+ + +
Sbjct: 317 WRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE-----------KMR 365
Query: 254 ESRRKGGLDYLKQVENETRNKSENEKNRNQED---NKVKDLNQEIEKLKTQIKHFESLEE 310
E K + E E + + + +K R+QE+ + + L ++ E+++ Q K +E +E+
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 311 --ELKKM---KSKNNDLQDNYLSEQ---NKNKLLASQLEEIKLQIKKQKELENGEVEGED 362
E KKM + K D ++ E+ + K + + E ++ Q +K ++ E E E+
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485
Score = 48.1 bits (113), Expect = 4e-05
Identities = 58/330 (17%), Positives = 130/330 (39%), Gaps = 34/330 (10%)
Query: 123 LEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASE 182
L +AF S C L E ++L ++ + L + R K ++ +
Sbjct: 143 LSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEEL 202
Query: 183 LEKLKSLTLSFVSERKYLNEKEKENEKL-----------------IKELTQKLEQNKKMN 225
++ +L+L E +K+N +L +KEL +KLE+ K +
Sbjct: 203 TKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL 262
Query: 226 RDYTRNASNLERNDLRIEDGI---SSTLPSKESRRKGGLDYLKQVENETRNKSE----NE 278
N L+ R E+ + + +E + + L++ E + R + E E
Sbjct: 263 PQVQTN--TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQE 320
Query: 279 KNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLAS 338
K +++ ++++ +E+ + K + E ++E+ +KM + +++ + + L
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
Query: 339 QLEEIKLQIKKQKELENGEVEGEDAFLSSKGR--------HERTKFRGHGSEASVSKHTA 390
Q ++++ Q +K ++ E E ++ + R + K R K T
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 391 RELSPQHKRERLRNREFALNNENYSLSNRQ 420
+ + ER+R RE + E ++ ++
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQE 470
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 77.8 bits (190), Expect = 5e-14
Identities = 94/406 (23%), Positives = 184/406 (45%), Gaps = 47/406 (11%)
Query: 19 KLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGK 78
K+++L+ + L+E+ L K E LQ+ QA G + + L + LR+E +
Sbjct: 1023 KVKNLTEEMAALDESVARLTK---EKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQ 1079
Query: 79 DEEIKRAEDLCRLMKEKL--EEEENLTRELKSEIERLQKRMAEL----EKLEEAFSRSKN 132
E+++ C L +EK + E R+L+ +++ Q+ +A+ ++LEE + +
Sbjct: 1080 VEDLE-----CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDS 1134
Query: 133 DCTQLCLSLNEERNLTKKISSELEMLRVKVKELE-------SSEDRLDKTEQSLASEL-- 183
+ +QL L + +E+ L ++ +++ L+ + +ELE ++ R++K A EL
Sbjct: 1135 ELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEE 1194
Query: 184 --EKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNK----KMNRDYTRNASNLER 237
E+L+ + +R+ ++E E +L +EL + +++ + R A+ L
Sbjct: 1195 LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254
Query: 238 NDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDN------KVKD 290
++ K R D VE TR K+ EK R ED KV++
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 291 LNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQ-LEEIKLQIKK 349
L +++ TQ ++ EL ++ + L +S+ ++ K LA+Q LEE++ Q+++
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSRLLEEKECL----ISQLSRGKALAAQSLEELRRQLEE 1370
Query: 350 QKELENGEVEGEDAFLSSKGRHERTKFR-GHGSEASVSKHTARELS 394
+ + ++ A RH+ R H EA R LS
Sbjct: 1371 ESKAKSALAHAVQAL-----RHDCDLLREQHEEEAEAQAELQRLLS 1411
Score = 63.5 bits (153), Expect = 1e-09
Identities = 84/414 (20%), Positives = 173/414 (41%), Gaps = 35/414 (8%)
Query: 16 LRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML-AEIEVLRQR--- 71
L FK++ L R EE L EL L+ + AE + + + +++
Sbjct: 881 LFFKMKPLLRSAQAEEE----LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL 936
Query: 72 VLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK 131
L+++ + + + AE+ C L+ + + E +EL +E ++ A+L + +
Sbjct: 937 ALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRR---KLE 993
Query: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTL 191
++CT+L +++ + K E + KVK L LD++ L E + L+
Sbjct: 994 DECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Query: 192 SFVSERK-------YLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
+ + + L + + E+ +++L LEQ KK+ D R LE + ++
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQE 1113
Query: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRN----QEDNKVKDLNQEIEKLKT 300
++ K+ + LK+ ++E S ++ Q K+K+L E+L+
Sbjct: 1114 SVADAAQDKQQLE----EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEE 1169
Query: 301 QIKHFESLEEELKKMKSK-NNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
+++ + ++K +++ +L++ + A Q E + K++ EL E
Sbjct: 1170 ELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCR---KREAELGRLRRE 1226
Query: 360 GEDAFLSSKGRHERTKFRGHGSEASVSKHTAREL-SPQHKRERLRNREFALNNE 412
E+A L RHE T +A + ++ S Q R++L + L E
Sbjct: 1227 LEEAAL----RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRME 1276
Score = 57.0 bits (136), Expect = 9e-08
Identities = 121/614 (19%), Positives = 232/614 (37%), Gaps = 76/614 (12%)
Query: 17 RFKLQSLSRRLDELEEATKNLQKAEDELLDLQDK----VIQAEGSNSSMLAEIEVLRQRV 72
+ K++ L R+L + LQ EL L ++ + Q + +E LR R
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELR-RQ 1367
Query: 73 LRIEGKDEE-----IKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAF 127
L E K + ++ C L++E+ EEE EL+ + + +A+ EA
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEA- 1426
Query: 128 SRSKNDCTQLCLSLNEERNLTKKISSEL-------EMLRVKVKELESSEDRLDKTEQSLA 180
D Q L E + KK++ L E K LE ++ RL + +
Sbjct: 1427 -----DAIQRTEELEEAK---KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDL 240
ELE+ S + L++K++ E+ ++E ++ E+ ++ R + L
Sbjct: 1479 LELERATSAAAA-------LDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELF 1531
Query: 241 RIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKT 300
R+ G L + E+ ++ + +++ + T S + K+ + + K L E +++
Sbjct: 1532 RLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQA 1591
Query: 301 QIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEG 360
++ E EL++ K+ L+ + + + KL E L+ Q+ +E+ +
Sbjct: 1592 ALEEAEG-ALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA-S 1649
Query: 361 EDAFLSSKGRHERTKFRGHGSEASVS---KHTARELSPQHKRERLR----NREFALNNEN 413
DA ++ R K + G + H R+ + RL E A +E
Sbjct: 1650 LDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE 1709
Query: 414 YSLSNRQVSSPSFTNRR----AAKASHMGVSTDSGTQETKKTEDRFVPGS-------SQS 462
L+ RR AA+ + + + G + + E + + SQ+
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQN 1769
Query: 463 EG------KKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTH 516
G K + + AAQE +A + K T++ + + K +
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQ------- 1822
Query: 517 GSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGAL-ASSRRSSS 575
D ++ T +TV + + + QAA G K + L A R +
Sbjct: 1823 -----DTSAHLERMKKTLEQTVRELQARL----EEAEQAALRGGKKQVQKLEAKVRELEA 1873
Query: 576 EGLSKGKKAANGLE 589
E ++ KK A L+
Sbjct: 1874 ELDAEQKKHAEALK 1887
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.123 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,389,971
Number of Sequences: 37866
Number of extensions: 2005108
Number of successful extensions: 19437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 395
Number of HSP's successfully gapped in prelim test: 1365
Number of HSP's that attempted gapping in prelim test: 8348
Number of HSP's gapped (non-prelim): 5902
length of query: 1076
length of database: 18,247,518
effective HSP length: 113
effective length of query: 963
effective length of database: 13,968,660
effective search space: 13451819580
effective search space used: 13451819580
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.