Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21493031
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
(1058 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 2061 0.0
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 2061 0.0
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 2061 0.0
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 597 e-170
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 597 e-170
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 581 e-165
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 581 e-165
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 574 e-163
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 571 e-162
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 189 1e-47
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 189 1e-47
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 189 1e-47
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 178 3e-44
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 178 3e-44
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 169 2e-41
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 82 3e-15
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 82 3e-15
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 82 3e-15
gi|38373682 pleckstrin homology domain containing family G membe... 79 3e-14
gi|111154084 pleckstrin homology domain containing family G memb... 79 3e-14
gi|111154088 pleckstrin homology domain containing family G memb... 79 3e-14
gi|111154080 pleckstrin homology domain containing family G memb... 79 3e-14
gi|111154078 pleckstrin homology domain containing family G memb... 79 3e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 78 5e-14
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 78 5e-14
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 77 1e-13
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 76 2e-13
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 75 4e-13
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 75 4e-13
gi|148746195 trichohyalin [Homo sapiens] 69 2e-11
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 2061 bits (5339), Expect = 0.0
Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)
Query: 1 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60
MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK
Sbjct: 1760 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 1819
Query: 61 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120
DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR
Sbjct: 1820 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 1879
Query: 121 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180
SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK
Sbjct: 1880 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 1939
Query: 181 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240
ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR
Sbjct: 1940 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 1999
Query: 241 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300
QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR
Sbjct: 2000 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 2059
Query: 301 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360
ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY
Sbjct: 2060 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 2119
Query: 361 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420
AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA
Sbjct: 2120 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 2179
Query: 421 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480
QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD
Sbjct: 2180 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 2239
Query: 481 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540
GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE
Sbjct: 2240 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 2299
Query: 541 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600
KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD
Sbjct: 2300 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 2359
Query: 601 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660
TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL
Sbjct: 2360 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 2419
Query: 661 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720
KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ
Sbjct: 2420 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 2479
Query: 721 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780
MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL
Sbjct: 2480 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 2539
Query: 781 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840
QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL
Sbjct: 2540 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 2599
Query: 841 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900
EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR
Sbjct: 2600 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 2659
Query: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960
AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI
Sbjct: 2660 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 2719
Query: 961 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020
AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG
Sbjct: 2720 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 2779
Query: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058
LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2780 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 2061 bits (5339), Expect = 0.0
Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)
Query: 1 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60
MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK
Sbjct: 1 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60
Query: 61 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120
DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR
Sbjct: 61 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120
Query: 121 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180
SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK
Sbjct: 121 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180
Query: 181 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240
ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR
Sbjct: 181 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240
Query: 241 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300
QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR
Sbjct: 241 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300
Query: 301 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360
ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY
Sbjct: 301 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360
Query: 361 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420
AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA
Sbjct: 361 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420
Query: 421 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480
QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD
Sbjct: 421 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480
Query: 481 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540
GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE
Sbjct: 481 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540
Query: 541 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600
KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD
Sbjct: 541 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600
Query: 601 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660
TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL
Sbjct: 601 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660
Query: 661 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720
KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ
Sbjct: 661 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720
Query: 721 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780
MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL
Sbjct: 721 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780
Query: 781 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840
QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL
Sbjct: 781 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840
Query: 841 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900
EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR
Sbjct: 841 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900
Query: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960
AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI
Sbjct: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960
Query: 961 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020
AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG
Sbjct: 961 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020
Query: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058
LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 2061 bits (5339), Expect = 0.0
Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)
Query: 1 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60
MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK
Sbjct: 1756 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 1815
Query: 61 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120
DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR
Sbjct: 1816 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 1875
Query: 121 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180
SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK
Sbjct: 1876 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 1935
Query: 181 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240
ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR
Sbjct: 1936 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 1995
Query: 241 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300
QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR
Sbjct: 1996 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 2055
Query: 301 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360
ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY
Sbjct: 2056 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 2115
Query: 361 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420
AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA
Sbjct: 2116 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 2175
Query: 421 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480
QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD
Sbjct: 2176 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 2235
Query: 481 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540
GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE
Sbjct: 2236 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 2295
Query: 541 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600
KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD
Sbjct: 2296 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 2355
Query: 601 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660
TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL
Sbjct: 2356 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 2415
Query: 661 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720
KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ
Sbjct: 2416 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 2475
Query: 721 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780
MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL
Sbjct: 2476 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 2535
Query: 781 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840
QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL
Sbjct: 2536 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 2595
Query: 841 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900
EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR
Sbjct: 2596 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 2655
Query: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960
AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI
Sbjct: 2656 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 2715
Query: 961 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020
AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG
Sbjct: 2716 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 2775
Query: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058
LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2776 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 161 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 220
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 188 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240
Query: 221 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 280
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
Query: 281 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 340
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
Query: 341 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 400
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Query: 401 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 460
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
Query: 461 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 520
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
Query: 521 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
Query: 581 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 635
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 601 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
Query: 636 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 694
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 660 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709
Query: 695 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 741
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 710 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766
Query: 742 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 792
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 767 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826
Query: 793 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 827 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886
Query: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 887 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946
Query: 911 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 956
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 947 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005
Query: 957 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 1016
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055
Query: 1017 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 1047
K K K K+ SQ + AS
Sbjct: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 161 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 220
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 30 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82
Query: 221 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 280
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 83 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142
Query: 281 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 340
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 143 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202
Query: 341 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 400
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 203 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262
Query: 401 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 460
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 263 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322
Query: 461 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 520
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 323 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382
Query: 521 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 383 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442
Query: 581 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 635
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 443 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501
Query: 636 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 694
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 502 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551
Query: 695 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 741
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 552 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608
Query: 742 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 792
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 609 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668
Query: 793 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 669 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728
Query: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 729 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788
Query: 911 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 956
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 789 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847
Query: 957 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 1016
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 848 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897
Query: 1017 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 1047
K K K K+ SQ + AS
Sbjct: 898 ----------KGGKDKGGKSRGSQRWESSAS 918
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 581 bits (1498), Expect = e-165
Identities = 368/894 (41%), Positives = 543/894 (60%), Gaps = 58/894 (6%)
Query: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAY 63
S++ K +EK+K+KE KD + NGH F++I V G C C K T K+A
Sbjct: 15 SRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTMCYACNKSITAKEAL 66
Query: 64 TCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAV 123
C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R+K + +ERP SA+
Sbjct: 67 ICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAI 124
Query: 124 LLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISK 183
D + + +RR + S+SL+KSVS NI G NDE+ + LS STDSLN ++
Sbjct: 125 YPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNR 183
Query: 184 VNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEV 243
S ESL DE ++ +L+ DFE++ K A+SWS +DS FL+Q KK+V+K+Q+V
Sbjct: 184 TL-SVESLIDEA---EVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDV 239
Query: 244 IYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILE 303
IYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DEL IH++F ++LE
Sbjct: 240 IYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLE 299
Query: 304 RKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKD 363
R++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H++++ +K+LYA+D
Sbjct: 300 RRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARD 359
Query: 364 KRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSL 423
KRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ + E E++DL +L
Sbjct: 360 KRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTAL 419
Query: 424 SLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV 483
LVK+++ VD + EK RL EIY + D ++ + F +E+L R+KL+ DG +
Sbjct: 420 GLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCL 479
Query: 484 FLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGL 543
K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+ LIVR++A++EKG+
Sbjct: 480 LWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGM 538
Query: 544 FLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRA 603
FLIS PEM EVH +S+++R++WI++IQ ++ T ED + E E+E +
Sbjct: 539 FLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL-IETEDEAYL----- 590
Query: 604 RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSPTHSPRVLFRSNTEE 658
R +K +L QKD+ ++ LL EK +F +M ED PT PR LFRS + E
Sbjct: 591 RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLE 647
Query: 659 ALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDS 718
+ +G L++ AI EVE L+ L+ G G L T P +LP ++ GG S
Sbjct: 648 SPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP---------ALPLEPDS-GGNTS 696
Query: 719 HQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELL 777
+ A+ GE + +L R +SDS + + GN L+ E+ +Q +V+LY LL
Sbjct: 697 PGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQEEALQRLVNLYGLL 749
Query: 778 SALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQK 834
LQ V QQD+ +E + ER L R+ SR + EKQ +LA LQ+
Sbjct: 750 HGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQR 809
Query: 835 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQK 888
Q A EE RR R E R E EA R E +Q + LE+E EE +++
Sbjct: 810 QHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLEREAEEARRQ 859
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 581 bits (1497), Expect = e-165
Identities = 368/894 (41%), Positives = 543/894 (60%), Gaps = 59/894 (6%)
Query: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAY 63
S++ K +EK+K+KE KD + NGH F++I V G C C K T K+A
Sbjct: 15 SRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTMCYACNKSITAKEAL 66
Query: 64 TCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAV 123
C C+ +H C+++LA+C KVK KQ K +L ++T+ L +V +R+K + +ERP SA+
Sbjct: 67 ICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAI 124
Query: 124 LLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISK 183
D + + +RR + S+SL+KSVS NI G NDE+ + LS STDSLN ++
Sbjct: 125 YPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNR 183
Query: 184 VNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEV 243
S ESL DE ++ +L+ DFE++ K A+SWS +DS FL+Q KK+V+K+Q+V
Sbjct: 184 TL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDV 238
Query: 244 IYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILE 303
IYEL+QTE HHVRTLKIM+ ++ GM+ +L E +V+ LFPC+DEL IH++F ++LE
Sbjct: 239 IYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLE 298
Query: 304 RKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKD 363
R++++L S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H++++ +K+LYA+D
Sbjct: 299 RRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARD 358
Query: 364 KRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSL 423
KRFQ F++K +V++R G+ ECILLVTQRITKYP+L RILQ + E E++DL +L
Sbjct: 359 KRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTAL 418
Query: 424 SLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV 483
LVK+++ VD + EK RL EIY + D ++ + F +E+L R+KL+ DG +
Sbjct: 419 GLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCL 478
Query: 484 FLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGL 543
K A GR K+V +L+TD+LVFLQEKDQKYIF +LD K +V+SL+ LIVR++A++EKG+
Sbjct: 479 LWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGM 537
Query: 544 FLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRA 603
FLIS PEM EVH +S+++R++WI++IQ ++ T ED + E E+E +
Sbjct: 538 FLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL-IETEDEAYL----- 589
Query: 604 RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSPTHSPRVLFRSNTEE 658
R +K +L QKD+ ++ LL EK +F +M ED PT PR LFRS + E
Sbjct: 590 RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLE 646
Query: 659 ALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDS 718
+ +G L++ AI EVE L+ L+ G G L T P +LP ++ GG S
Sbjct: 647 SPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP---------ALPLEPDS-GGNTS 695
Query: 719 HQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELL 777
+ A+ GE + +L R +SDS + + GN L+ E+ +Q +V+LY LL
Sbjct: 696 PGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQEEALQRLVNLYGLL 748
Query: 778 SALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQK 834
LQ V QQD+ +E + ER L R+ SR + EKQ +LA LQ+
Sbjct: 749 HGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQR 808
Query: 835 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQK 888
Q A EE RR R E R E EA R E +Q + LE+E EE +++
Sbjct: 809 QHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLEREAEEARRQ 858
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 574 bits (1479), Expect = e-163
Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)
Query: 29 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 88
KD + NGH F++I V G C C K T K+A C C+ +H C+++LA+C KVK
Sbjct: 5 KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64
Query: 89 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 148
KQ K +L ++T+ L +V +R+K + +ERP SA+ D + + +RR + S+SL+K
Sbjct: 65 KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121
Query: 149 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 208
SVS NI G NDE+ + LS STDSLN ++ S ESL DE ++ +L+ D
Sbjct: 122 SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176
Query: 209 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 268
FE++ K A+SWS +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++ G
Sbjct: 177 FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236
Query: 269 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 328
M+ +L E +V+ LFPC+DEL IH++F ++LER++++L S +NF+I R+GD+L++
Sbjct: 237 MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296
Query: 329 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 388
QFSG +AE++ KTY +FC +H++++ +K+LYA+DKRFQ F++K +V++R G+ ECI
Sbjct: 297 QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356
Query: 389 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 448
LLVTQRITKYP+L RILQ + E E++DL +L LVK+++ VD + EK RL E
Sbjct: 357 LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416
Query: 449 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 508
IY + D ++ + F +E+L R+KL+ DG + K A GR K+V +L+TD+LVFLQ
Sbjct: 417 IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476
Query: 509 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 568
EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS PEM EVH +S+++R++
Sbjct: 477 EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533
Query: 569 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 628
WI++IQ ++ T ED + E E+E + R +K +L QKD+ ++ LL EK +F
Sbjct: 534 WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587
Query: 629 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 683
+M ED PT PR LFRS + E+ +G L++ AI EVE L+ L+ G
Sbjct: 588 AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644
Query: 684 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 743
G L T P +LP ++ GG S + A+ GE + +L R +S
Sbjct: 645 -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691
Query: 744 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 801
DS + + GN L+ E+ +Q +V+LY LL LQ V QQD+ +E + ER
Sbjct: 692 DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746
Query: 802 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 859
L R+ SR + EKQ +LA LQ+Q A EE RR R E R E
Sbjct: 747 EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806
Query: 860 REALLAQREEEVQQGQQDLEKEREELQQK 888
EA R E +Q + LE+E EE +++
Sbjct: 807 LEA----RLRESEQARALLEREAEEARRQ 831
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 571 bits (1471), Expect = e-162
Identities = 354/940 (37%), Positives = 539/940 (57%), Gaps = 78/940 (8%)
Query: 14 KDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH 73
++K K K KD+KDKEK +N H F+ G + C C K K++ C+NC+A VH
Sbjct: 634 RNKSKTKSKDAKDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVH 689
Query: 74 KGCRESLASCAKVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQP 115
KGC+++ +C K ++ P+ L H +SS+P + P+
Sbjct: 690 KGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGR 745
Query: 116 KERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHST 175
+E L T + + RRS S+ E+ N+ + SHS
Sbjct: 746 RETVGQVHPLSRSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSD 790
Query: 176 DSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK 235
+ L + + STES E D+ + L D ++++ EAESWS ++D F +Q+K
Sbjct: 791 ELLQSMGS-SPSTESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEK 845
Query: 236 DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHS 295
DV+KRQ+VI+ELMQTE HH++TL IMS ++ +GM +L + V+K+FPCLDEL+ IH
Sbjct: 846 DVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHR 905
Query: 296 QFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNY 355
FF + ER++ES S++NF+I RIGD+LV QFS ENA ++KK YG+FC H ++VN
Sbjct: 906 HFFYSMKERRQESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNL 964
Query: 356 FKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVE 415
FK+L ++K+FQ F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+ E
Sbjct: 965 FKELQ-QNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEE 1023
Query: 416 QEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--K 473
+DL ++L L+KD+I VD KV YEK + EI K ++K+ ++K+G +F K+ L +
Sbjct: 1024 HKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSE 1083
Query: 474 RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIV 533
+ L+ DG V+ K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI
Sbjct: 1084 ERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIA 1143
Query: 534 REVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENE 593
REVA+EE+G+FLIS PEM E+H +SKEERN+W++ IQ + + +E G SE++
Sbjct: 1144 REVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESD 1202
Query: 594 EEKKMLDTRA---RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPR 649
E+K+ + R ++ +E L +DQ+I LEEK I+ ++ E S H P
Sbjct: 1203 EDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPH 1257
Query: 650 VLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRR 709
+L + + E + L+ +A+ E E LQ V + G + + V+
Sbjct: 1258 LLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL-------- 1309
Query: 710 AETFGGFD---SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE 764
A+T D S + GG + G D ++ +D + G +S+
Sbjct: 1310 ADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQ 1369
Query: 765 -QVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQR 820
+++Q++ +L LL +LQ + QDS+IE +LVL ++ +L S+ R L + +K R
Sbjct: 1370 SEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSR 1428
Query: 821 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 880
++Q ++LAN+ + Q Q +E+RR R E ++R RE+ L +RE E Q ++ L +
Sbjct: 1429 DADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLR 1488
Query: 881 EREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERL 920
R EL + YQ+ LERLR Q+ +EREQ ++R + L
Sbjct: 1489 SRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLL 1528
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 192 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 248
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 381 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 440
Query: 249 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 441 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 500
Query: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 501 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 553
Query: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 554 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 612
Query: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 485
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 613 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 671
Query: 486 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 534
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 672 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 731
Query: 535 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 732 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 777
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 192 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 248
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 333 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392
Query: 249 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 393 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452
Query: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 453 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505
Query: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 506 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564
Query: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 485
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 565 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623
Query: 486 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 534
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 624 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683
Query: 535 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 684 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 189 bits (480), Expect = 1e-47
Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)
Query: 192 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 248
TDEG T+ E G+ +LE E W ++ L K VKRQEVI EL+
Sbjct: 366 TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 425
Query: 249 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308
TE HVR L+++ ++ Q M L F + ++ +FP LDELI +HS F R+++R++ES
Sbjct: 426 VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 485
Query: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368
+LI+ IGDVL+ +F G +K +FC + + ++ K KD RF A
Sbjct: 486 -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 538
Query: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428
FV++ S RRL + + I QR+TKYP+L Q I Q T++ E+E + + ++
Sbjct: 539 FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 597
Query: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 485
++ V+ V E +RL + + D S +R S M F D+ +KKLV +G +
Sbjct: 598 ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 656
Query: 486 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 534
+ + EV +LL D+L+ LQ +D++ + S + T V+ L + R
Sbjct: 657 RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 716
Query: 535 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
EVA + K +++ + ++ E+ A + ER +W +I +T +L
Sbjct: 717 EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 762
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 178 bits (451), Expect = 3e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 59
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 555 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614
Query: 60 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 113
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 615 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667
Query: 114 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 173
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 668 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718
Query: 174 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 233
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 719 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768
Query: 234 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 293
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 769 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
Query: 294 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 353
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 829 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880
Query: 354 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 413
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 881 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940
Query: 414 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 471
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 941 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000
Query: 472 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 523
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060
Query: 524 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 579
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120
Query: 580 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 608
R D+ + E E E+ T +++ +
Sbjct: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180
Query: 609 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 667
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236
Query: 668 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 710
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296
Query: 711 ETFGGFDSHQMNASKGGEKEEGDDG 735
G D+ Q+ +G E+ D G
Sbjct: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 178 bits (451), Expect = 3e-44
Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)
Query: 4 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 59
+KKS +KEKD +++K+++ K K + + IP+ V P + ++ F N
Sbjct: 515 TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574
Query: 60 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 113
Y + + ES +S +++++ + + SL+ + + R++ +
Sbjct: 575 NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627
Query: 114 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 173
+ R RS V + D A A R Q + S + S+S +++ + T K
Sbjct: 628 ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678
Query: 174 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 233
S +S + T++L + D+ + L D E E +A++W + +
Sbjct: 679 SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728
Query: 234 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 293
+ + RQEVI EL TE H+RTL+++ ++ Q M + L ++ + +LFP L ELI I
Sbjct: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
Query: 294 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 353
H+ + + + + ++E + IK I D+++ +F G E L++ +FC + ++
Sbjct: 789 HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840
Query: 354 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 413
K K+ RFQ F+++ S RRL + + I+ QR+TKYP+L + I++ T+
Sbjct: 841 ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900
Query: 414 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 471
E E L ++ ++++ V+ V E + RL + D+ ++ R + F D
Sbjct: 901 SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960
Query: 472 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 523
L +K++ +G + + + + ++ +LL D+LV LQ++D+K + S D K
Sbjct: 961 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020
Query: 524 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 579
T V+ L +++R VA +++ F+I + + P++ E+ A + ++N+W++++++ +
Sbjct: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080
Query: 580 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 608
R D+ + E E E+ T +++ +
Sbjct: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140
Query: 609 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 667
HQ +LL E+E + P P + + R+ A G M+
Sbjct: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196
Query: 668 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 710
SA+ +VE L+ L+ +L G T+ + E D+ S+ P +A
Sbjct: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256
Query: 711 ETFGGFDSHQMNASKGGEKEEGDDG 735
G D+ Q+ +G E+ D G
Sbjct: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 169 bits (427), Expect = 2e-41
Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)
Query: 178 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 229
L+++ + E +T+ G + G+ + E +Q E + +W +++ +
Sbjct: 718 LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777
Query: 230 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 289
L K +KRQEVI EL TE HVRTLK++ V+ Q + + + + K+F L++
Sbjct: 778 LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837
Query: 290 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 349
++ +H +++ V K + +I +IG+ L+ FSG E+LK FC
Sbjct: 838 ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891
Query: 350 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 409
++ K KD RFQ FV+ S+ + RRL + + I QR+TKYP+L I + T
Sbjct: 892 PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951
Query: 410 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 467
+ E+E + ++ + ++ V+ V E K RL + + D+ S + + +
Sbjct: 952 -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010
Query: 468 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 519
DL ++K++ +G + K + ++ +LL DILV LQ++D K + ++
Sbjct: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070
Query: 520 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 576
D K T VI L ++VR+VA + K LF+ISM ++ E+ A + E+ W +I
Sbjct: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130
Query: 577 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 611
++ + IP +N+EE +LKE+ H
Sbjct: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 81.6 bits (200), Expect = 3e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 102 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 162 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212
Query: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 213 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266
Query: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 451
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 267 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326
Query: 452 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 479
+ K + S + +LK + V+
Sbjct: 327 EEGQKDSLIDSSRVLCCHGELKNNRGVK 354
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 81.6 bits (200), Expect = 3e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 128 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 188 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238
Query: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 239 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292
Query: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 451
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 293 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352
Query: 452 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 479
+ K + S + +LK + V+
Sbjct: 353 EEGQKDSLIDSSRVLCCHGELKNNRGVK 380
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 81.6 bits (200), Expect = 3e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 96 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 155
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 156 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 206
Query: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 207 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 260
Query: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 451
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 261 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 320
Query: 452 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 479
+ K + S + +LK + V+
Sbjct: 321 EEGQKDSLIDSSRVLCCHGELKNNRGVK 348
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 3e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 593 EEEKK 597
EEE++
Sbjct: 717 EEEEE 721
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 78.6 bits (192), Expect = 3e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 395 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 451 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505
Query: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 506 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561
Query: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 562 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620
Query: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 621 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680
Query: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 681 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733
Query: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592
V + AS + W+ I Q + +L +EDE E
Sbjct: 734 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793
Query: 593 EEEKK 597
EEE++
Sbjct: 794 EEEEE 798
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 3e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 593 EEEKK 597
EEE++
Sbjct: 717 EEEEE 721
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 78.6 bits (192), Expect = 3e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 318 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 374 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428
Query: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 429 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484
Query: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 485 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543
Query: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 544 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603
Query: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 604 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656
Query: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592
V + AS + W+ I Q + +L +EDE E
Sbjct: 657 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716
Query: 593 EEEKK 597
EEE++
Sbjct: 717 EEEEE 721
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 78.6 bits (192), Expect = 3e-14
Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)
Query: 219 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 272
+SW +ID K ++Q +QE ++EL+ TE ++R L+++ ++ ++ +
Sbjct: 374 DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 331
LL E + E+LF + E+ +H + + ++ +++K+ + + + GD L +
Sbjct: 430 LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484
Query: 332 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 391
G L K Y ++C + + Y + L + F+A++ +RL + + +
Sbjct: 485 GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
Query: 392 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 451
QR+TKYP+L + +L+ T++ ++ +A + V+ I V++ + +++ RL + +
Sbjct: 541 HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599
Query: 452 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 495
+ D+ ++ S ++ F DL + ++L+ +GS+ +K +V
Sbjct: 600 RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659
Query: 496 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 553
L TD+L+ + + +++ VI L+ + V E + G FL+
Sbjct: 660 YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712
Query: 554 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 592
V + AS + W+ I Q + +L +EDE E
Sbjct: 713 SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772
Query: 593 EEEKK 597
EEE++
Sbjct: 773 EEEEE 777
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 77.8 bits (190), Expect = 5e-14
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 148 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 208 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259
Query: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 260 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312
Query: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 452
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 313 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372
Query: 453 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 510
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 373 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418
Query: 511 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 555
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 419 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475
Query: 556 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 608
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 476 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534
Query: 609 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 663
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 535 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 77.8 bits (190), Expect = 5e-14
Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)
Query: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
+K+ + WS ++D + ++RQE IYE+ + E + LK+ Y M+
Sbjct: 94 AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153
Query: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
+ ++ + +F LD I +H RI E K + +++IG +LV+
Sbjct: 154 SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205
Query: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
NA Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 206 LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258
Query: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 452
R+ KYP+L + IL+ T + + L ++ +++ V+ ++ K E + ++++
Sbjct: 259 SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318
Query: 453 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 510
+ + R+++ K L+ G L++ +G ++ L DILV + +
Sbjct: 319 DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364
Query: 511 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 555
++++ + Q I +++L++ ++ ++ EK + + DP
Sbjct: 365 NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421
Query: 556 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 608
+ H A+ + W I+ I + + E +G+P E EE + AR+L
Sbjct: 422 AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480
Query: 609 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 663
Q + +E E +R MAE S L TH + R ++AL GG
Sbjct: 481 QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 76.6 bits (187), Expect = 1e-13
Identities = 99/460 (21%), Positives = 198/460 (43%), Gaps = 57/460 (12%)
Query: 141 QQSVSLSKSVSIQNI-----TGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEG 195
+++ +LS SIQ T + N E S +TDS + N S S G
Sbjct: 105 EKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDG----NASDSSYRTPG 160
Query: 196 VGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQ----QKKDVVKRQEVIYELMQTE 251
+G + + E E+K E E+ ++ + L Q ++ + K ++ EL+ TE
Sbjct: 161 IGPVLPLEER--GAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTE 218
Query: 252 FHHVRTLKIMSGVYSQGMMADL---LFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 308
+V L ++ V+ ++ + F +MV K+F + + + HS+F LE++ +
Sbjct: 219 RAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQE 278
Query: 309 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 368
RIGD+L + K YG++ + ++ K++ + +F++
Sbjct: 279 WETTP-------RIGDIL------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKS 325
Query: 369 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 428
V++ + L + +L QRI +Y +L + L+ + ++ D +SL ++
Sbjct: 326 VVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIST 385
Query: 429 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNA 488
+S + E +L EIY + + S + L+++G + LK A
Sbjct: 386 AASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNE-----------LIKEGQI-LKLA 433
Query: 489 AGRL--KEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV---ISLKKLIVREVAHEE-KG 542
A +E L ++L++ K F+ + K TV + + + + E +EE
Sbjct: 434 ARNTSAQERYLFLFNNMLLYCVPK-----FSLVGSKFTVRTRVGIDGMKIVETQNEEYPH 488
Query: 543 LFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNR 582
F +S +E+ ASS +++ WI+ +Q+TI+ ++
Sbjct: 489 TFQVS---GKERTLELQASSAQDKEEWIKALQETIDAFHQ 525
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 75.9 bits (185), Expect = 2e-13
Identities = 78/347 (22%), Positives = 145/347 (41%), Gaps = 27/347 (7%)
Query: 239 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 298
KRQ I+EL+ TE ++V L++++ ++ + +M L ++ V +F ELI + +
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 299 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 358
+ + RKK S + +K IGD+L Q + Y +FC + +
Sbjct: 1297 KALRVRKK-----MSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 359 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 418
+ F+ FVK+ + + + IL QR+T+YP++ + IL+ T +N +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 419 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 478
L +L +++ V+ V E RL I + + L +K +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS-VTNCLGPRKFL 1464
Query: 479 RDGSVFLKNAAGRLKEVQAVLLTDILVFLQ------EKDQKYIF---ASLDQK--STVIS 527
G ++ A KE+ L D L+ Q +F ++L K T I
Sbjct: 1465 HSGKLY---KAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIF 1521
Query: 528 LKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQ 574
L +++V+ + + D + + A S ER +W+Q I+
Sbjct: 1522 LNEVLVKLPTDPSGDEPIFHISHID-RVYTLRAESINERTAWVQKIK 1567
Score = 60.8 bits (146), Expect = 6e-09
Identities = 43/147 (29%), Positives = 87/147 (59%), Gaps = 12/147 (8%)
Query: 785 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 844
L ++ +ED++ L ++ + E+ LEK+RQ L Q+++ + L +
Sbjct: 329 LPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLE-LEKRRQALLEQQRKEQERLAQLE 387
Query: 845 RREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQK 904
R E+E + RER+ +ER+ L + E+++++ Q++LE++REE ++K ++ER AA++
Sbjct: 388 RAEQERKERERQEQERKRQL-ELEKQLEK-QRELERQREEERRK------EIERREAAKR 439
Query: 905 QLEREQE---QLRREAERLSQRQTERD 928
+LER+++ + R E L+QR E++
Sbjct: 440 ELERQRQLEWERNRRQELLNQRNKEQE 466
Score = 53.9 bits (128), Expect = 8e-07
Identities = 52/178 (29%), Positives = 87/178 (48%), Gaps = 23/178 (12%)
Query: 775 ELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQK 834
EL Q ++ QQ E ++L ERA R EQE++R LE ++Q L+K
Sbjct: 364 ELEKRRQALLEQQRK--EQERLAQLERAEQERKERERQ--EQERKRQLELEKQ----LEK 415
Query: 835 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDL----EKEREE---LQQ 887
Q+ LE +R ER E RE +RE ++ E + +Q+L KE+E+ L+
Sbjct: 416 QRE--LERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKA 473
Query: 888 KKGTYQYDLERLRAAQKQLEREQEQLR------REAERLSQRQTERDLCQVSHPHTKL 939
KK T +++LE L + QLE + + +R R+ + + E + +++H +L
Sbjct: 474 KKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQL 531
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/237 (19%), Positives = 109/237 (45%), Gaps = 18/237 (7%)
Query: 736 QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQK 795
Q++ T L+ +L L+ + + + + + L L+ V QQ+S D
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQV--QQNSLHRDSL 565
Query: 796 LVLSERALTRSLSRP---SSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRR--REREW 850
+ L + L+R L E EK+ + Q D+ N Q ++ + + K++ +++
Sbjct: 566 VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM 625
Query: 851 EARERELREREALLAQREEEVQQGQQDL-EKEREELQQKKGTYQYDLERLRAAQKQLERE 909
EA + +E+E + + E++ ++ Q+ E++++ L+ + ++ R +++L+RE
Sbjct: 626 EAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685
Query: 910 QEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSL 966
+ +++ E +++ + L ++ H H + P +P + S A+ G L
Sbjct: 686 ESVKKKDGEEKGKQEAQDKLGRLFHQHQE----------PAKPAVQAPWSTAEKGPL 732
Score = 35.8 bits (81), Expect = 0.22
Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 9/137 (6%)
Query: 785 LQQDSYIEDQKLVLSERALTRSLS---RPSSLIEQEKQRSLE---KQRQDLANLQKQQAQ 838
L+ + +E Q+ + +R R R ++ E E+QR LE +RQ+L N + ++ +
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQE 466
Query: 839 YLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLER 898
+ + +++ E L +++ Q E ++Q + L +R+E++ + + +
Sbjct: 467 DIVVLKAKKKTLEFELEALNDKK---HQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAE 523
Query: 899 LRAAQKQLEREQEQLRR 915
+ Q+QL+ Q+ L R
Sbjct: 524 ITHLQQQLQESQQMLGR 540
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 74.7 bits (182), Expect = 4e-13
Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)
Query: 239 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 298
KRQ I+EL+QTE ++ L+++ V+ + M + + +F ELI +++
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 299 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 358
+ + RKK + ++ IGD+L + S A Y +FC +
Sbjct: 1242 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1290
Query: 359 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 418
+D F+ F+KK S + + + +L QRIT+YP+L + IL+ T ++ +
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 419 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 478
L +L +++ V+ V E RL I + + L +KL+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1409
Query: 479 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 526
G ++ + KE+ L D L+ F + +F+S T I
Sbjct: 1410 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1466
Query: 527 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 586
L +++V+ + + D + + + ER +W+Q I+ ++
Sbjct: 1467 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1518
Query: 587 GIPSENEEEKKMLDTRARE 605
I +E ++ +K R+++
Sbjct: 1519 YIDTEKKKREKAYQARSQK 1537
Score = 62.8 bits (151), Expect = 2e-09
Identities = 40/111 (36%), Positives = 72/111 (64%), Gaps = 13/111 (11%)
Query: 822 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 881
LEK+RQ L Q+++A+ + ++ + EWE ++REL+E+E E+ + Q++LE++
Sbjct: 378 LEKRRQALMEQQQREAE--RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ 435
Query: 882 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 928
REE ++K D+ER AA+++LER E E++RR+ E L+Q+ E++
Sbjct: 436 REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479
Score = 51.2 bits (121), Expect = 5e-06
Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
ED++ ER R +L+EQ+++ + K +++ +++Q + E++ +++ E E
Sbjct: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423
Query: 852 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 895
R + RE E QREEE ++ +Q+LE++R +EL +K Q +
Sbjct: 424 KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 896 LERLRAAQKQLEREQEQLRREAERLSQR 923
+ RL + +K L E E L + +++S R
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGR 508
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)
Query: 833 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 888
QK+ E+KR+ E E E R R+AL+ Q++ E Q+ +++ E+++ ELQ++
Sbjct: 356 QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414
Query: 889 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 927
+ Q +LE+ Q++LER++E+ RR E ++++ ER
Sbjct: 415 EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Score = 44.7 bits (104), Expect = 5e-04
Identities = 48/226 (21%), Positives = 100/226 (44%), Gaps = 42/226 (18%)
Query: 744 DSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERAL 803
D LKK + +L + + + + L + L Q ++ Y+ +K +L+ER
Sbjct: 511 DVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI----YLVPEKQLLNERIK 566
Query: 804 TRSLSR-PSSLIEQEKQRSLEKQ------RQDLANLQKQQAQYLEE-------------- 842
S P S + ++SLEK+ ++ L L+K+ A L E
Sbjct: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRET 626
Query: 843 --------------KRRREREWEARERELREREALLAQREEEVQQGQQDLEKE--REELQ 886
KR + +E E + EL +++ L + + +QG+++L KE R+E +
Sbjct: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE 686
Query: 887 QKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 932
+K+ Q + + + +++ + E++Q R++ + L + +R+ V
Sbjct: 687 EKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 731
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/254 (21%), Positives = 116/254 (45%), Gaps = 21/254 (8%)
Query: 817 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWE-ARERELREREALLAQREEEVQQ 873
EKQR LE+QR++ ++++++A E +R+R EWE R +EL ++ + +
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486
Query: 874 GQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREA--ERLSQRQTERDLCQ 931
+++L E E L K L+ +R ++ + E E L ++ E + +Q +++L +
Sbjct: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
Query: 932 VSH------PHTKLM--RIPS--FFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISR 981
+ P +L+ RI + F +P+ S S+ SL+ E + +
Sbjct: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPD-----SGVSLLHKKSLEKEELCQRLKEQLDA 601
Query: 982 THKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQP 1041
K+ + S N+ E + A +L+ + + K K+ ++K+ + + +
Sbjct: 602 LEKETAS-KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660
Query: 1042 GDGPASEVSAEGEE 1055
+ A+ + +G+E
Sbjct: 661 LEDEAARKAKQGKE 674
Score = 31.2 bits (69), Expect = 5.4
Identities = 16/67 (23%), Positives = 38/67 (56%), Gaps = 3/67 (4%)
Query: 866 QREEEVQQGQQDLEKEREEL---QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQ 922
+R+ ++G +LEK R+ L QQ++ + E+ +KQ E ++++ +++ E +
Sbjct: 366 KRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR 425
Query: 923 RQTERDL 929
+ +R+L
Sbjct: 426 LEKQREL 432
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 74.7 bits (182), Expect = 4e-13
Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)
Query: 239 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 298
KRQ I+EL+QTE ++ L+++ V+ + M + + +F ELI +++
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 299 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 358
+ + RKK + ++ IGD+L + S A Y +FC +
Sbjct: 1269 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1317
Query: 359 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 418
+D F+ F+KK S + + + +L QRIT+YP+L + IL+ T ++ +
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 419 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 478
L +L +++ V+ V E RL I + + L +KL+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1436
Query: 479 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 526
G ++ + KE+ L D L+ F + +F+S T I
Sbjct: 1437 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1493
Query: 527 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 586
L +++V+ + + D + + + ER +W+Q I+ ++
Sbjct: 1494 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1545
Query: 587 GIPSENEEEKKMLDTRARE 605
I +E ++ +K R+++
Sbjct: 1546 YIDTEKKKREKAYQARSQK 1564
Score = 62.8 bits (151), Expect = 2e-09
Identities = 40/111 (36%), Positives = 72/111 (64%), Gaps = 13/111 (11%)
Query: 822 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 881
LEK+RQ L Q+++A+ + ++ + EWE ++REL+E+E E+ + Q++LE++
Sbjct: 378 LEKRRQALMEQQQREAE--RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ 435
Query: 882 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 928
REE ++K D+ER AA+++LER E E++RR+ E L+Q+ E++
Sbjct: 436 REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479
Score = 51.2 bits (121), Expect = 5e-06
Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
ED++ ER R +L+EQ+++ + K +++ +++Q + E++ +++ E E
Sbjct: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423
Query: 852 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 895
R + RE E QREEE ++ +Q+LE++R +EL +K Q +
Sbjct: 424 KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 896 LERLRAAQKQLEREQEQLRREAERLSQR 923
+ RL + +K L E E L + +++S R
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGR 508
Score = 48.1 bits (113), Expect = 4e-05
Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)
Query: 833 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 888
QK+ E+KR+ E E E R R+AL+ Q++ E Q+ +++ E+++ ELQ++
Sbjct: 356 QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414
Query: 889 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 927
+ Q +LE+ Q++LER++E+ RR E ++++ ER
Sbjct: 415 EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 15/100 (15%)
Query: 817 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQG 874
EKQR LE+QR++ ++++++A E +R+R EWE R+ LL Q+ E
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWER-----IRRQELLNQKNRE---- 477
Query: 875 QQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLR 914
++E L KK +LE L +Q+ + +R
Sbjct: 478 ----QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVR 513
Score = 38.5 bits (88), Expect = 0.034
Identities = 26/113 (23%), Positives = 61/113 (53%), Gaps = 3/113 (2%)
Query: 822 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 881
L++ R+ Q Q + KR + +E E + EL +++ L + + +QG+++L KE
Sbjct: 647 LKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE 706
Query: 882 --REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 932
R+E ++K+ Q + + + +++ + E++Q R++ + L + +R+ V
Sbjct: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 758
Score = 37.4 bits (85), Expect = 0.075
Identities = 26/95 (27%), Positives = 53/95 (55%), Gaps = 8/95 (8%)
Query: 814 IEQEKQRSLEKQRQDLANLQKQQAQYLEE-KRRREREWEARERELREREALLAQREEEVQ 872
I+++K + +E++R +L +K + + + K+ +E W+ R+ E E +EE+ Q
Sbjct: 667 IKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK-EEEEKQKRLQEEKTQ 725
Query: 873 QGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLE 907
+ Q+ E++ EE Q+K D + L+A +K+ E
Sbjct: 726 EKIQEEERKAEEKQRK------DKDTLKAEEKKRE 754
Score = 31.2 bits (69), Expect = 5.4
Identities = 16/67 (23%), Positives = 38/67 (56%), Gaps = 3/67 (4%)
Query: 866 QREEEVQQGQQDLEKEREEL---QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQ 922
+R+ ++G +LEK R+ L QQ++ + E+ +KQ E ++++ +++ E +
Sbjct: 366 KRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR 425
Query: 923 RQTERDL 929
+ +R+L
Sbjct: 426 LEKQREL 432
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 69.3 bits (168), Expect = 2e-11
Identities = 64/229 (27%), Positives = 111/229 (48%), Gaps = 18/229 (7%)
Query: 717 DSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNA---------NLVFMLKRNSE-QV 766
+ Q+ + KG E EE D + LRR E +KG + VF + E +
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 767 VQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQR 826
++V+ E + Q++ E+++L ER R + +Q +R + +R
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 827 QDLANLQKQQAQYLEEKRRREREWEARERELR----EREALLAQREEEVQQGQQDLEKER 882
+ ++QQ + E++ RRE++ E RE++LR ER +RE+E ++ +Q L +E+
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 883 EEL---QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERD 928
EE QQ + Q E+ ++QL REQ QLRRE + ++Q R+
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRRE 416
Score = 63.5 bits (153), Expect = 1e-09
Identities = 51/148 (34%), Positives = 82/148 (55%), Gaps = 17/148 (11%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQ--DLANLQKQQAQYLEEK 843
++ Y E+++L E L R E+EK+R E +RQ LQ+++ Q L E+
Sbjct: 986 REKKYREEEELQQEEEQLLRE--------EREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 844 RRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQ 903
R + R E RER+ RE E L Q+EEE G++ + R+EL+++ Y+ + E L+ +
Sbjct: 1038 REKRRLQE-RERQYREEEEL--QQEEEQLLGEERETRRRQELERQ---YRKE-EELQQEE 1090
Query: 904 KQLEREQEQLRREAERLSQRQTERDLCQ 931
+QL RE+ + RR ER Q + E +L Q
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQ 1118
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/129 (31%), Positives = 75/129 (58%), Gaps = 16/129 (12%)
Query: 815 EQEKQRSLEKQRQDLANLQKQQAQYL----EEKRRREREWEARERELREREALLAQREEE 870
E +++ LE+Q + LQ+++ Q L E++RR+ERE + RE E ++E REE
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 871 VQQGQQDLEK---EREELQQKKGTY---------QYDLERLRAAQKQLEREQEQLRREAE 918
++ +Q+LE+ E EE+QQ++ + +LER +++L++E+EQL RE +
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 919 RLSQRQTER 927
+++ ER
Sbjct: 1189 EKRRQERER 1197
Score = 62.0 bits (149), Expect = 3e-09
Identities = 47/138 (34%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 809 RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLA--- 865
R L+E ++ EKQ+Q ++Q + EE+ E+EW RE LR+ E L
Sbjct: 211 RRRELLELRRKGREEKQQQ---RRERQDRVFQEEE---EKEWRKRETVLRKEEEKLQEEE 264
Query: 866 -QREEEVQQGQQDLEK-EREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQR 923
QR+ E+Q+ ++ L K ER+EL++++ + +RLR Q QL R+QE+ RRE + +
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLRRKQEEERREQQEERRE 323
Query: 924 QTERDLCQVSHPHTKLMR 941
Q ER Q +L R
Sbjct: 324 QQERREQQEERREQQLRR 341
Score = 61.6 bits (148), Expect = 4e-09
Identities = 45/144 (31%), Positives = 79/144 (54%), Gaps = 15/144 (10%)
Query: 799 SERALTRSLSRPSSLIEQEKQ-RSLEKQRQDLANLQKQQAQYLEEKRRREREWEAR---- 853
SER R +RP ++E+Q R+ E+Q+++ L +++ + ++RRERE E +
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 854 ERELRERE-ALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR---------AAQ 903
E +L+ RE A Q EE+ Q Q+ + +E+ + +K +Q + ER R A Q
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 904 KQLEREQEQLRREAERLSQRQTER 927
+QL +EQ+ L+ E E L + + E+
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREK 920
Score = 60.8 bits (146), Expect = 6e-09
Identities = 50/156 (32%), Positives = 90/156 (57%), Gaps = 23/156 (14%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLAN--LQKQQAQYL--- 840
Q+ Y E+++L E L R E+EK+R E++RQ + LQ+++ Q L
Sbjct: 926 QERQYREEEQLQQEEEQLLRE--------EREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 841 -EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE---REELQQKKGTY---Q 893
E++RR+ERE + RE E ++E REE ++ +Q+ E++ ++ELQQ++ +
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 894 YDLERLRAAQKQLEREQEQLRREAERL--SQRQTER 927
+ RL+ ++Q RE+E+L++E E+L +R+T R
Sbjct: 1038 REKRRLQERERQY-REEEELQQEEEQLLGEERETRR 1072
Score = 60.5 bits (145), Expect = 8e-09
Identities = 45/162 (27%), Positives = 86/162 (53%), Gaps = 22/162 (13%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR- 844
++ Y +D+KL E L E+ +++ EK+ ++ LQ+++ Q L E+R
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEP------EKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 845 -RREREWEARER---ELREREALLAQREEEVQQGQ---------QDLEKEREEL--QQKK 889
RR +EWE + R EL++ E L + E E ++ Q ++L++E E+L ++++
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 890 GTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQ 931
+ +LER +++L++E+EQL RE +RQ C+
Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Score = 60.1 bits (144), Expect = 1e-08
Identities = 43/142 (30%), Positives = 80/142 (56%), Gaps = 15/142 (10%)
Query: 792 EDQKLVLSERALTRSLS-----RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRR 846
E+++L+ ER R R ++QE+++ L ++R+ LQ+++ QY EE+ +
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK-RRLQERERQYREEEELQ 1057
Query: 847 EREWE--ARERELREREALLAQ--REEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAA 902
+ E + ERE R R+ L Q +EEE+QQ ++ L +E E ++++ + ER
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ-----ERERQCRE 1112
Query: 903 QKQLEREQEQLRREAERLSQRQ 924
+++L++E+EQL RE +RQ
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQ 1134
Score = 59.7 bits (143), Expect = 1e-08
Identities = 42/143 (29%), Positives = 79/143 (55%), Gaps = 13/143 (9%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
E+++L ERA +QE++RS E++R QK + Q EE++RR
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD-----QKWRWQLEEERKRRRHTLY 890
Query: 852 AR---ERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLER 908
A+ + +LR+ + LL + EEE+Q+ +++ + +E+ +Q + + E+L+ ++QL R
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR-----EEEQLQQEEEQLLR 945
Query: 909 EQEQLRREAERLSQRQTERDLCQ 931
E+ + RR ER Q + ++ L Q
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQ 968
Score = 59.3 bits (142), Expect = 2e-08
Identities = 54/202 (26%), Positives = 105/202 (51%), Gaps = 22/202 (10%)
Query: 728 EKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQ 787
E+EE + Q L+R E + L++ + L+R E+ + +LL + L+Q
Sbjct: 510 EQEERRE-QRLKRQEEEERLQQRLRSEQ--QLRREQEERRE------QLLKREEEKRLEQ 560
Query: 788 DSYIEDQKLVLSERA---LTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 844
+ + K ER L R R +++E++ LE++ L++++ + LE++
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR------LKREEVERLEQEE 614
Query: 845 RREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQK 904
RRE+ + E E R+ LL E+E ++ QQ L +E++E ++++ + + ERL ++
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQE-ERRQQQLRREQQERREQRLKREEEEERL---EQ 670
Query: 905 QLEREQEQLRREAERLSQRQTE 926
+L+RE E+ RRE E + Q +
Sbjct: 671 RLKREHEEERREQELAEEEQEQ 692
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/138 (29%), Positives = 85/138 (61%), Gaps = 7/138 (5%)
Query: 794 QKLVLSERALTRSLS-RPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEA 852
Q+ + SE+ L R R L+++E+++ LE++R++ L+++Q + ++ +RE E
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKREEE-RR 586
Query: 853 RERELREREALLAQR--EEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
++R RE+E L QR EEV++ +Q E+ RE+ +++ + ++L +++Q ER Q
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQ--EERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 911 EQLRREAERLSQRQTERD 928
+QLRRE + +++ +R+
Sbjct: 645 QQLRREQQERREQRLKRE 662
Score = 58.5 bits (140), Expect = 3e-08
Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 38/208 (18%)
Query: 728 EKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQ 787
E++ +D Q LRR E L++ + R EQ++Q
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKF-----REDEQLLQER----------------- 1631
Query: 788 DSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRRE 847
E+Q+L ER + L L QE+++ L R ++Q Q EE++ R
Sbjct: 1632 ----EEQQLHRQERD-RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Query: 848 REWEARERELREREALLAQRE-------EEVQQGQQDLEKE-REELQQKKGTYQYDLERL 899
+E R+R+ RE E L ++E EE Q +Q+LE++ REE Q ++ T Q L R
Sbjct: 1687 QE---RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 900 RAAQKQLEREQEQLRREAERLSQRQTER 927
+K LE EQ + RE ++L +++ +R
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDR 1771
Score = 57.8 bits (138), Expect = 5e-08
Identities = 53/172 (30%), Positives = 85/172 (49%), Gaps = 33/172 (19%)
Query: 785 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQ--DLANLQKQQAQYL-- 840
LQ+ E Q L E L R E+EK+R E++RQ + LQ+++ Q L
Sbjct: 895 LQEQLRKEQQLLQEEEEELQRE--------EREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Query: 841 --EEKRRREREWEAR------------------ERELREREALLAQREEEVQQGQQDLEK 880
E++RR+ERE + R +R +ERE + EE Q+ +Q L +
Sbjct: 947 EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 881 EREELQQKKGTYQY-DLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQ 931
ERE+ ++++ QY + L+ ++QL RE+ + RR ER Q + E +L Q
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Score = 57.8 bits (138), Expect = 5e-08
Identities = 44/153 (28%), Positives = 78/153 (50%), Gaps = 16/153 (10%)
Query: 793 DQKLVLSERALTRSLS----RPSSLIEQEKQRSLEKQRQDLANLQKQ-----QAQYLEEK 843
D+K + E+ L R R L QE +R ++ Q L Q+Q + Q L +
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 844 RRREREWEARERELREREALLAQREEEVQQGQQD-----LEKEREELQQKKGTYQYDLER 898
R ++ + R+R+ RE E L +REE+ Q+ LE+++ Q+++ + D ++
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 899 LRA--AQKQLEREQEQLRREAERLSQRQTERDL 929
LR Q+QL +E+++ RE E+L Q + E+ L
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Score = 57.0 bits (136), Expect = 9e-08
Identities = 50/173 (28%), Positives = 88/173 (50%), Gaps = 30/173 (17%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEK-- 843
Q+ ++ED++ + + + +++Q E++ Q L + Q++ ++LEE+
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL-HRQERDRKFLEEEPQ 1651
Query: 844 -RRREREWEAR---ERELREREALLAQREE-------------EVQQGQQDLEKEREELQ 886
RR+ERE + R +R+ RE E LL + EE E +Q + E+ER+ LQ
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711
Query: 887 QKKGTYQYDLERLRAAQKQL--EREQEQLRR--------EAERLSQRQTERDL 929
+++ + +LER ++QL E EQEQLRR E E+L + E+ L
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL 1764
Score = 56.2 bits (134), Expect = 2e-07
Identities = 47/159 (29%), Positives = 78/159 (49%), Gaps = 26/159 (16%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
E+Q+L ER R R E+E+ R E++ Q L+ ++ + LEE++ R +E E
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQ-EREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 852 A---------------------RERELREREALLAQREEEVQQGQQDLEKEREELQQKKG 890
R+R+ RE E LL +REE+ Q E++R+ L+++
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ---ERDRKFLEEEPQ 1651
Query: 891 TYQYDLE-RLRAAQKQLEREQEQLRREAERLSQRQTERD 928
+ + E +LR + + RE+EQL +E E R+ ERD
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690
Score = 56.2 bits (134), Expect = 2e-07
Identities = 41/128 (32%), Positives = 75/128 (58%), Gaps = 12/128 (9%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
E+Q +E+ R R ++E+E+ R E++ Q L ++ + EE+ R+ERE
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRP-EREEQQLRRQERDRKFREEEQLRQERE-- 1784
Query: 852 ARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQE 911
E++LR +E+ REEE Q +Q+ E+++ QQ+ G Y+++ E+L QLE +++
Sbjct: 1785 --EQQLRSQESDRKFREEE--QLRQEREEQQLRPQQRDGKYRWEEEQL-----QLEEQEQ 1835
Query: 912 QLRREAER 919
+LR+E +R
Sbjct: 1836 RLRQERDR 1843
Score = 55.8 bits (133), Expect = 2e-07
Identities = 43/151 (28%), Positives = 79/151 (52%), Gaps = 12/151 (7%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ----------RQDLANLQKQQAQYLE 841
E+++L+ ER R R E+E+ + E+Q RQ+L +++ + +
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQ 1088
Query: 842 EKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQY-DLERLR 900
E+ + RE E +R +ERE + EE Q+ +Q L +ERE+ ++++ QY + E ++
Sbjct: 1089 EEEQLLRE-EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 901 AAQKQLEREQEQLRREAERLSQRQTERDLCQ 931
++QL RE+ + RR E Q + E +L Q
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Score = 55.5 bits (132), Expect = 3e-07
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 14/149 (9%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQ-RSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
E+Q L E R R E+E+Q R E++R+ L Q+ + Q LE K R E +
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 851 -----------EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERL 899
+ R R++ E E L +REE+ + Q+ K REE Q ++ + L
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 900 RAAQKQLEREQEQLRREAERLSQRQTERD 928
+ +K RE+EQLR+E E R +RD
Sbjct: 1792 ESDRK--FREEEQLRQEREEQQLRPQQRD 1818
Score = 55.1 bits (131), Expect = 3e-07
Identities = 57/214 (26%), Positives = 108/214 (50%), Gaps = 25/214 (11%)
Query: 728 EKEEGDDGQDLRRTES---DSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVV 784
E+EE Q LRR + + L++ L+R + + + + L Q +
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 785 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 844
+Q+ +QK R + L R EQE++R K+ ++ ++ + + +++
Sbjct: 427 REQEEERHEQKHEQERRE--QRLKR-----EQEERRDWLKREEET---ERHEQERRKQQL 476
Query: 845 RREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR---A 901
+R++E E RER L+ E +R E+ ++ +Q L +E+EE ++++ Q + ERL+
Sbjct: 477 KRDQEEERRERWLKLEEE---ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 902 AQKQLEREQEQ-----LRREAE-RLSQRQTERDL 929
+++QL REQE+ L+RE E RL Q + E+ L
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Score = 55.1 bits (131), Expect = 3e-07
Identities = 52/164 (31%), Positives = 83/164 (50%), Gaps = 34/164 (20%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQR--SLEKQRQDLANLQKQQAQYLEE---KRRR 846
E+++L E L R E+EK+R LE+Q ++ +Q+++ Q L E KRRR
Sbjct: 1112 EEEELQQEEEQLLRE--------EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 847 ---EREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQ 903
ER++ E +E E LL + +E+ +Q ++ +E EELQ++K +Y E R+
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 904 K-QLE----------------REQEQLRR-EAERLSQRQTERDL 929
K Q E RE EQ R+ E +L RQ+++DL
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Score = 54.7 bits (130), Expect = 5e-07
Identities = 40/156 (25%), Positives = 83/156 (53%), Gaps = 16/156 (10%)
Query: 814 IEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQ 873
+E+E++R +++R+ L+++Q + E++ +R+ E E ++ LR + L ++EE +Q
Sbjct: 491 LEEEERREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 874 -----GQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAE-RLSQRQTER 927
++ LE+ER E + K+ + + R + +++ ER Q++L+RE E RL QR
Sbjct: 549 LLKREEEKRLEQERREQRLKR---EQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 928 DLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKS 963
++ ++ + R+ EEP + KS
Sbjct: 606 EVERLEQEERREQRL-----KREEPEEERRQQLLKS 636
Score = 54.7 bits (130), Expect = 5e-07
Identities = 37/137 (27%), Positives = 76/137 (55%), Gaps = 9/137 (6%)
Query: 802 ALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRRERE----WEAREREL 857
AL L + L+ QE++ L+++ ++ Q+Q+ QY EE++ ++ E E RE+
Sbjct: 894 ALQEQLRKEQQLL-QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 858 REREALLAQREEEVQQGQQDL---EKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLR 914
R+ ++++++QQ ++ L E E+ Q+++ Y+ + E L+ ++QL RE+ + R
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE-EELQQEEEQLLREEREKR 1011
Query: 915 REAERLSQRQTERDLCQ 931
R E Q + + +L Q
Sbjct: 1012 RRQEWERQYRKKDELQQ 1028
Score = 54.3 bits (129), Expect = 6e-07
Identities = 78/354 (22%), Positives = 143/354 (40%), Gaps = 42/354 (11%)
Query: 582 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 641
+ E+E + E E EK+ R R+ +E+ + ++ LL EE+E R E E+
Sbjct: 1087 QQEEEQLLRE-EPEKRRRQERERQCREEEELQQEEEQLLREEREK--RRRQELERQYREE 1143
Query: 642 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 701
L R E+ + L + E E+ Q E+ ++
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQ-ELERQYREEEELQQE------------------EEQLL 1184
Query: 702 GPVSLPRRAETFGGF-DSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLK 760
RR E + + ++ K ++ +D + + + + + N V+
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 761 RNSEQVVQ---SVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQE 817
R +EQ Q S + + LQ ++ +Q +Q+ R R P E++
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE---RRRWQQRDRHFPE---EEQ 1298
Query: 818 KQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQD 877
+R +K+ + +++ Q L E+R +R + +R+ RE E LL +REE+ + Q+
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 878 LEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQ 931
K REE +L +K LE EQ R+E ER ++ ++ CQ
Sbjct: 1359 DRKFREE----------ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ 1402
Score = 53.9 bits (128), Expect = 8e-07
Identities = 45/160 (28%), Positives = 81/160 (50%), Gaps = 11/160 (6%)
Query: 785 LQQDSYIEDQKLVLSERALTRS--LSRPSSLI-EQEKQRSLEKQRQDLANLQKQQAQYLE 841
L+++ + ++ + E+ L R L R L EQ+ +R E++R + + Q+++ Q L+
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 842 EKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRA 901
++ R+W RE E E +E QQ ++D E+ER E + K + E+
Sbjct: 449 REQEERRDWLKREEETERHE-----QERRKQQLKRDQEEERRE-RWLKLEEEERREQQER 502
Query: 902 AQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 941
++QL REQE+ R +RL +++ E L Q +L R
Sbjct: 503 REQQLRREQEE--RREQRLKRQEEEERLQQRLRSEQQLRR 540
Score = 53.9 bits (128), Expect = 8e-07
Identities = 42/147 (28%), Positives = 74/147 (50%), Gaps = 17/147 (11%)
Query: 793 DQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEA 852
+Q+L + L R E++R ++ ++D ++++ LEE+ RRE++ E
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ-ER 502
Query: 853 RERELR--------------EREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLER 898
RE++LR E E L QR QQ +++ E+ RE+L +++ + + ER
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 899 --LRAAQKQLEREQEQLRREAERLSQR 923
R ++Q ER + L+RE ER QR
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQR 589
Score = 53.5 bits (127), Expect = 1e-06
Identities = 45/160 (28%), Positives = 81/160 (50%), Gaps = 19/160 (11%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQ-------------RSLEKQRQDLANL 832
QQ S E + E R R +E+E+Q + L+++ + +
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 833 QKQQAQYLEEK---RRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKK 889
Q++ ++LEE+ RR+ER+ + RE+ELR +E EEE Q +Q +++R+ LQ+++
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ--QRQRKFLQEEQ 1538
Query: 890 GTYQYDLERLRAAQKQLE-REQEQLRREAERLSQRQTERD 928
+ + + R + + RE+EQLR+E E + ERD
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578
Score = 52.8 bits (125), Expect = 2e-06
Identities = 36/120 (30%), Positives = 69/120 (57%), Gaps = 9/120 (7%)
Query: 815 EQEKQRSLEKQRQDLANLQKQQAQYLEEKRRR------EREWEARERELREREALLAQRE 868
EQ+++R ++ R++ ++QQ + +E+ RR E+E E RE++LR + L +RE
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL--RRE 386
Query: 869 EEVQQGQQ-DLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTER 927
+++++ QQ E++ QQ + Q E+ ++QL REQE+ R E + +R+ +R
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446
Score = 51.6 bits (122), Expect = 4e-06
Identities = 38/122 (31%), Positives = 72/122 (59%), Gaps = 11/122 (9%)
Query: 815 EQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQ----REEE 870
EQ+ +R E++R++ L+++Q E++ RRE++ RE++LR + L + RE++
Sbjct: 361 EQQLRREQEEERRE-QQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQ 418
Query: 871 VQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQ----LEREQEQLRREAERLSQRQTE 926
+++ QQ ++ EE ++K + +RL+ Q++ L+RE+E R E ER Q Q +
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ-QLK 477
Query: 927 RD 928
RD
Sbjct: 478 RD 479
Score = 51.6 bits (122), Expect = 4e-06
Identities = 43/163 (26%), Positives = 81/163 (49%), Gaps = 29/163 (17%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLE------KQRQDLANLQKQQAQYLEEKRR 845
E+Q+L ER R E+E+Q S + ++ + Q+++ ++LEE+++
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454
Query: 846 REREWEARERELREREALLAQREEEV---QQGQQDLEKEREELQQKKGTYQYDLERLRA- 901
+E R R+ RE E LL +REE+ Q+ + +E ++L++++ ++ + LR+
Sbjct: 1455 LRQE---RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 902 --------AQKQLEREQ--------EQLRREAERLSQRQTERD 928
++QL R+Q EQ R ER QR+ +RD
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Score = 51.2 bits (121), Expect = 5e-06
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 7/137 (5%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRR-REREW 850
E+Q+L ER + L L QE+++ L + R ++QQ E R+ RE E
Sbjct: 1379 EEQRLRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
+ R +E RER+ L EEE Q Q+ K REE Q + + L R +K LE EQ
Sbjct: 1438 QVRRQE-RERKFL----EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492
Query: 911 EQLRREAERLSQRQTER 927
+ R+E +R + Q R
Sbjct: 1493 QLRRQERDRKFREQELR 1509
Score = 50.4 bits (119), Expect = 9e-06
Identities = 38/151 (25%), Positives = 75/151 (49%), Gaps = 14/151 (9%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL----- 840
++D +Q+L S+ + L L Q++QR ++ Q L ++ Q +
Sbjct: 1498 ERDRKFREQEL-RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 841 ---EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLE 897
EE+ R+ERE + R+ R+R+ L +++ Q+ ++ ++ ++L++++G Q
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ---- 1612
Query: 898 RLRAAQKQLEREQEQLRREAERLSQRQTERD 928
LR + + RE EQL +E E + ERD
Sbjct: 1613 -LRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Score = 50.4 bits (119), Expect = 9e-06
Identities = 45/146 (30%), Positives = 69/146 (47%), Gaps = 13/146 (8%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEK-- 843
QQ + D+K E+ L L QE+ R ++ Q L Q+++ ++L+E+
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEG--EEQQLRRQERDRKFREEEQQLRR-QERERKFLQEEQQ 1715
Query: 844 -RRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAA 902
RR+E E R+ RE E L + E+E + Q+ K EE Q + + L R
Sbjct: 1716 LRRQELE-----RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 903 QKQLEREQEQLRREAERLSQRQTERD 928
+K RE+EQLR+E E R E D
Sbjct: 1771 RK--FREEEQLRQEREEQQLRSQESD 1794
Score = 50.1 bits (118), Expect = 1e-05
Identities = 32/116 (27%), Positives = 67/116 (57%), Gaps = 8/116 (6%)
Query: 813 LIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQ 872
L E+++ R E++R+ L Q+ + Q E++ R++R+ R+ RE E L+++E + +
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD-----RKFREEEQQLSRQERDRK 1431
Query: 873 QGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERD 928
+++ + R+E ++K + + ++LR + + RE+EQL +E E + ERD
Sbjct: 1432 FREEEQQVRRQERERK---FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/132 (32%), Positives = 65/132 (49%), Gaps = 24/132 (18%)
Query: 815 EQEKQRSLEKQRQDLANLQKQQA-----QYLEEKRRRER--EWEARERELREREALLAQ- 866
++ +Q EK+R+ + LQ Q+ Q EE++RR+ +W+A E+ R R+ L A+
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 867 ----------REEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRRE 916
R EE QQ +Q E EE +Q++ R R + Q E+EQL+R
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ-----RREREKELQFLEEEEQLQRR 843
Query: 917 AERLSQRQTERD 928
ER Q Q E D
Sbjct: 844 -ERAQQLQEEED 854
Score = 49.3 bits (116), Expect = 2e-05
Identities = 43/160 (26%), Positives = 82/160 (51%), Gaps = 19/160 (11%)
Query: 786 QQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQ-----RSLEKQRQDLANLQKQQAQYL 840
Q+D + +++ + ER + R ++EKQ R +++RQ+ +++ Q L
Sbjct: 1288 QRDRHFPEEEQL--EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL 1345
Query: 841 EEK-----RRREREWEARERELREREALLAQREEEVQQGQQDLE----KEREEL--QQKK 889
+E+ RR+ER+ + RE ELR +E EEE + +Q+ E KE ++L Q+++
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 890 GTYQYDLER-LRAAQKQLEREQEQLRREAERLSQRQTERD 928
+ D +R R ++QL R++ + E R+ ER+
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Score = 48.9 bits (115), Expect = 3e-05
Identities = 43/148 (29%), Positives = 78/148 (52%), Gaps = 15/148 (10%)
Query: 785 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 844
L+++ E Q+ + + R L QE++ L+++ + L+++Q + E+
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 845 RRER----EWEARE----RELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDL 896
+RE E E RE RE ER L +REEE + QQ L++E+EE +++ + ++
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEE--RRQQRLKREQEERLEQR-LKREEV 607
Query: 897 ERLRAAQKQLEREQEQLRREAERLSQRQ 924
ERL +Q ER +++L+RE +RQ
Sbjct: 608 ERL----EQEERREQRLKREEPEEERRQ 631
Score = 48.9 bits (115), Expect = 3e-05
Identities = 41/140 (29%), Positives = 73/140 (52%), Gaps = 13/140 (9%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 851
E+Q E R R E+E+ R E++ Q L + + + EE+ R+ERE
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQ-EREEQQLRSQESDRKFREEEQLRQERE-- 1808
Query: 852 ARERELR--EREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLERE 909
E++LR +R+ EE++Q LE++ + L+Q++ QY E A Q++ RE
Sbjct: 1809 --EQQLRPQQRDGKYRWEEEQLQ-----LEEQEQRLRQERDR-QYRAEEQFATQEKSRRE 1860
Query: 910 QEQLRREAERLSQRQTERDL 929
+++L +E E+ +++ ER L
Sbjct: 1861 EQELWQEEEQKRRQERERKL 1880
Score = 48.1 bits (113), Expect = 4e-05
Identities = 55/158 (34%), Positives = 80/158 (50%), Gaps = 35/158 (22%)
Query: 793 DQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRR-----RE 847
D+K E+ L +P L QE+ R K R++ Q+Q ++LEE++R RE
Sbjct: 1335 DRKFREEEQLLQEREEQP--LRRQERDR---KFREEELRHQEQGRKFLEEEQRLRRQERE 1389
Query: 848 REWEARERELR--EREALLAQ------REEEVQQGQQDLEKE-REELQQKKGTYQYDLER 898
R++ E++LR ERE L Q REEE Q +Q+ +++ REE QQ + R
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ--------VRR 1441
Query: 899 LRAAQKQLEREQEQLR-------REAERLSQRQTERDL 929
+K LE EQ QLR RE E+L Q + E+ L
Sbjct: 1442 QERERKFLEEEQ-QLRQERHRKFREEEQLLQEREEQQL 1478
Score = 48.1 bits (113), Expect = 4e-05
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 793 DQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ---RQDLANLQKQQAQYLEEKRRRERE 849
D+K L E+ + R + ++++ R E Q RQ+ ++ Q L+E+ ++
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Query: 850 WEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLERE 909
+ R+R+ E E L ++E E Q K REE Q + + L R +K E E
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 910 QEQLRREAER 919
Q+ R+E ER
Sbjct: 1698 QQLRRQERER 1707
Score = 47.8 bits (112), Expect = 6e-05
Identities = 38/133 (28%), Positives = 73/133 (54%), Gaps = 19/133 (14%)
Query: 800 ERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE-----ARE 854
E + L R +E+Q E+Q + L+++Q E++ RRE++ RE
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 855 RELREREALLAQREE-------EVQQGQQDLEKEREE----LQQKKGTYQYDLERLRAAQ 903
++LR + L ++EE E ++ +Q L++E+EE L++++ T +++ ER +
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER---RK 473
Query: 904 KQLEREQEQLRRE 916
+QL+R+QE+ RRE
Sbjct: 474 QQLKRDQEEERRE 486
Score = 47.4 bits (111), Expect = 7e-05
Identities = 48/209 (22%), Positives = 95/209 (45%), Gaps = 22/209 (10%)
Query: 733 DDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIE 792
++ + L + + LK+ +LKR E+ Q L Q L+Q E
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR-------LKREQEERLEQRLKRE 605
Query: 793 DQKLVLSERALTRSLSRPSSLIEQEKQ--RSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
+ + + E + L R E+ +Q +S E++ + L+++Q + E++ +RE E
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQ------------YDLER 898
E E+ L+ RE +RE+E+ + +Q+ +ER + + K +Q Y R
Sbjct: 666 ERLEQRLK-REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 899 LRAAQKQLEREQEQLRREAERLSQRQTER 927
+ Q++ + ++E+ RR L ++ ER
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEER 753
Score = 46.6 bits (109), Expect = 1e-04
Identities = 40/159 (25%), Positives = 74/159 (46%), Gaps = 15/159 (9%)
Query: 784 VLQQDSYIEDQK-LVLSERALTRSLSRPSSLIEQEKQRSL---EKQRQDLANLQKQQAQY 839
+LQ EDQ+ +R L + QE++R L E+Q + L+++ Q
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 840 LEEKRRRER-EWEARERELREREALLAQREEEVQQGQQDLEKEREELQQ--KKGTYQYDL 896
+E+ R+R EW+ RE E E L + + E ++ + + R EL + +KG +
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 897 ERLRAAQKQLEREQEQ--------LRREAERLSQRQTER 927
+R + + E+E+ LR+E E+L + + +R
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Score = 45.4 bits (106), Expect = 3e-04
Identities = 33/156 (21%), Positives = 72/156 (46%), Gaps = 9/156 (5%)
Query: 792 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQA-QYLEEKRRRERE- 849
E+Q+L ER R L ++ +++ L Q D +++Q Q EE++ R ++
Sbjct: 1760 EEQQLRRQER--DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 850 -----WEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQK 904
WE + +L E+E L Q + + ++ + + ++++ +Q + ++ R ++
Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877
Query: 905 QLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLM 940
+ RE+ R++ E RQ Q H +L+
Sbjct: 1878 RKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL 1913
Score = 44.7 bits (104), Expect = 5e-04
Identities = 34/147 (23%), Positives = 74/147 (50%), Gaps = 21/147 (14%)
Query: 815 EQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEAR------------ERELREREA 862
+QE+ ++QR+D L +Q+ ++ E + RR E + + E +LR RE
Sbjct: 157 KQERLEQRDRQRRD-EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 863 LLAQRE--EEVQQGQQDL------EKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLR 914
L +R+ EE QQ +++ E+E +E ++++ + + E+L+ + Q +RE ++
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 915 REAERLSQRQTERDLCQVSHPHTKLMR 941
+ +L +++ R+ + +L R
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRR 302
Score = 44.3 bits (103), Expect = 6e-04
Identities = 43/154 (27%), Positives = 80/154 (51%), Gaps = 19/154 (12%)
Query: 790 YIEDQKLVLSERALTRSLSRPSSLIEQEK--QRSLEKQRQDLANLQKQQAQYLEEKRRRE 847
++E+++ + ++ + L L QE+ QR ++ R+ Q +Q + ++ R+E
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 848 REWEAR------ERELREREALLAQREEEVQQGQQDLEKER-------EELQQKKGTYQY 894
R+ + R R+ +ER+ + +++ Q+GQQ L +ER E+L Q++ Q
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ- 1635
Query: 895 DLERLRAAQKQLEREQEQLRREAERLSQRQTERD 928
L R +K LE E+ QLRR+ ER Q + +RD
Sbjct: 1636 -LHRQERDRKFLE-EEPQLRRQ-EREQQLRHDRD 1666
Score = 42.4 bits (98), Expect = 0.002
Identities = 47/177 (26%), Positives = 77/177 (43%), Gaps = 45/177 (25%)
Query: 816 QEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLA---------- 865
Q++ R +++R++ ++++ + LE++ +RE E E RE+EL E E A
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 866 ---QREEEVQQGQ---------QDLEKEREELQQKKGTYQYDL---ERLRAAQKQLEREQ 910
Q E E Q Q+ ++ R+E ++K+ + +L E RA ++Q E EQ
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 911 -----------EQLRREAERLSQR-----QTERDLCQVSHPHTKLMRIPSFFPSPEE 951
E+ R +RLS R Q ER L + R F P EE
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL----RAEERQQREQRFLPEEEE 816
Score = 41.2 bits (95), Expect = 0.005
Identities = 36/116 (31%), Positives = 62/116 (53%), Gaps = 16/116 (13%)
Query: 824 KQRQDLANLQKQQAQYLEEK-RRREREWEARERELREREALLAQREEEVQQGQQDLEKER 882
+Q +D + + Q EE +RR ++ + +EREL E E Q E++ + Q+D ++
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE---QSEKQERLEQRDRQRRD 170
Query: 883 EELQQKKGTYQYDLERLRAAQKQLER----------EQEQLRREAERLSQRQTERD 928
EEL +++ +Q ER RA ++QL+ ++EQLRR E L R+ R+
Sbjct: 171 EELWRQRQEWQEREER-RAEEEQLQSCKGHETEEFPDEEQLRRR-ELLELRRKGRE 224
Score = 40.4 bits (93), Expect = 0.009
Identities = 41/144 (28%), Positives = 68/144 (47%), Gaps = 28/144 (19%)
Query: 809 RPSSLIEQEKQRSL-----EKQRQDLANLQKQQAQYLEEKRR------------REREWE 851
R S L QE++R+ E+QR+D + QA+ E+ R RER+
Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFT--WQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 852 ARERELREREALLAQREEEVQQGQQDLEKERE--------ELQQKKGTYQYDLERLRAAQ 903
A ER+ RE+ L + EE+ Q+ +Q E+E+E +LQ+++ Q E +
Sbjct: 800 AEERQQREQR-FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 904 KQLEREQEQLRREAERLSQRQTER 927
Q R ++ RR+ + Q + ER
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEER 882
Score = 33.1 bits (74), Expect = 1.4
Identities = 23/97 (23%), Positives = 48/97 (49%), Gaps = 5/97 (5%)
Query: 836 QAQYLEEKRR-----REREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKG 890
QA L+E++R +E + R +E +R R+ E + GQ+ +K +E+ ++
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 891 TYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTER 927
+ ++ R Q+ +R E+L R+ + +R+ R
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,176,983
Number of Sequences: 37866
Number of extensions: 1944441
Number of successful extensions: 39283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 1156
Number of HSP's that attempted gapping in prelim test: 14000
Number of HSP's gapped (non-prelim): 14278
length of query: 1058
length of database: 18,247,518
effective HSP length: 113
effective length of query: 945
effective length of database: 13,968,660
effective search space: 13200383700
effective search space used: 13200383700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.