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Search of human proteins with 21389505
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
(626 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21389505 janus kinase and microtubule interacting protein 1 i... 1202 0.0
gi|150456473 janus kinase and microtubule interacting protein 1 ... 1155 0.0
gi|45237195 Janus kinase and microtubule interacting protein 2 [... 729 0.0
gi|157502225 Janus kinase and microtubule interacting protein 3 ... 713 0.0
gi|28416946 myosin 18A isoform a [Homo sapiens] 113 6e-25
gi|42794779 myosin 18A isoform b [Homo sapiens] 103 4e-22
gi|31982906 cingulin-like 1 [Homo sapiens] 95 2e-19
gi|148746195 trichohyalin [Homo sapiens] 94 3e-19
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 92 1e-18
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 88 2e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 88 2e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 88 2e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 88 2e-17
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 3e-17
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 88 3e-17
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 88 3e-17
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 88 3e-17
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 88 3e-17
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 88 3e-17
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 88 3e-17
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 88 3e-17
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 88 3e-17
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 87 6e-17
gi|16262452 cingulin [Homo sapiens] 86 8e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 86 1e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 1e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 84 4e-16
gi|58530840 desmoplakin isoform I [Homo sapiens] 82 1e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 80 4e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 80 6e-15
>gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
Length = 626
Score = 1202 bits (3109), Expect = 0.0
Identities = 626/626 (100%), Positives = 626/626 (100%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL
Sbjct: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA
Sbjct: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK
Sbjct: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
Query: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV
Sbjct: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
Query: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL
Sbjct: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL
Sbjct: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
Query: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA
Sbjct: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
Query: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE
Sbjct: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
Query: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE
Sbjct: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
Query: 601 LEVRDSICCKLSNGADILFEPKLKFM 626
LEVRDSICCKLSNGADILFEPKLKFM
Sbjct: 601 LEVRDSICCKLSNGADILFEPKLKFM 626
>gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
Length = 831
Score = 1155 bits (2987), Expect = 0.0
Identities = 603/605 (99%), Positives = 604/605 (99%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL
Sbjct: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA
Sbjct: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK
Sbjct: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
Query: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV
Sbjct: 241 EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSV 300
Query: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL
Sbjct: 301 IRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL
Sbjct: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL 420
Query: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA
Sbjct: 421 RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATA 480
Query: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE
Sbjct: 481 REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLE 540
Query: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE
Sbjct: 541 KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLE 600
Query: 601 LEVRD 605
LE R+
Sbjct: 601 LEERE 605
Score = 35.4 bits (80), Expect = 0.16
Identities = 40/149 (26%), Positives = 66/149 (44%), Gaps = 31/149 (20%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E A LT ++ ++EK + Q+ LE E + R+ + LK
Sbjct: 682 EGTEAALTQKMLDLEKEKDLFSR-----QKGYLEEELDYRKQALDQAYLK---------- 726
Query: 84 LQALREGLIRQHEQEAARTA--KIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
+Q L L +QE R A + EG+ + LQA A +KV+ +L ++RE
Sbjct: 727 IQDLEATLYTALQQEPGRRAGEALSEGQREDLQA--------AVEKVRRQILRQSRE--- 775
Query: 142 RAFDGERLRLQQEILELKAAR-KQAEEAL 169
FD + LR + E+L+ R ++ E+ L
Sbjct: 776 --FDSQILRERMELLQQAQQRIRELEDKL 802
>gi|45237195 Janus kinase and microtubule interacting protein 2
[Homo sapiens]
Length = 810
Score = 729 bits (1881), Expect = 0.0
Identities = 383/606 (63%), Positives = 482/606 (79%), Gaps = 12/606 (1%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLERE 59
MSKKGR+KGEKPE A+Q ANE+LR KLT IQIE QEKSKV KL RE+ QEAK RE
Sbjct: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
Query: 60 QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNV 119
EQR+HT ++ELKAKLHEEK KELQA+RE LI+QHEQE +RT K+++GE+QRL++ L
Sbjct: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
Query: 120 LRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
LRDG++DKV+TAL EAREEAR+ FD ERL+L QEI +LK A+KQ +EALSN +QADK K
Sbjct: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
Query: 180 AADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ 239
A DLR+ +Q+HQ+ + +IK E ERDIRRLMDEIK KDR+I +LEKEL Q G QKL LQ
Sbjct: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
Query: 240 KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNS 299
KEALDEQL VKEAE + SSPKRE+P GD +H D+RR Q +IAELN+
Sbjct: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGD-------GSEHCSSPDLRRNQKRIAELNA 293
Query: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
IRKLEDRNTLL DERNELLKR RETE Q KPL+E+NK + K+N++L+ S+QRMEEK+K
Sbjct: 294 TIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKA 353
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
+T+EN EM+EK+++ LK+ SLNDL +EQE EFL+LQV+EQQ++ID+L+ +RE+L
Sbjct: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
Query: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
+R ++HR +S KP K+ V++ F G+DE+S+DSET S S+ RTDRTPATP++DLD++
Sbjct: 414 IRRRKHR-RSSKPIKRPVLDPFIGYDEDSMDSETSSMASF---RTDRTPATPDDDLDESL 469
Query: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
A EE++LRF QLT+EYQALQRAYALLQEQ GG +DAEREA+ +EQLQA++LR +AKIEDL
Sbjct: 470 AAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDL 529
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVL 599
E L +KGQDS WVE+KQL I+ NQ+LLEKI + E E ++L+ E+QDA+DQNELLEFR L
Sbjct: 530 EATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNL 589
Query: 600 ELEVRD 605
ELE R+
Sbjct: 590 ELEERE 595
Score = 31.2 bits (69), Expect = 3.0
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 8/146 (5%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
++ A L K+ ++ + +Q G L E L K +Q R I EL+A L+
Sbjct: 670 IEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR----IQELEATLYN 725
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
+E L+ + +QE RTA K L+R + D + + LL +A +
Sbjct: 726 ALQQETVIKFGELLSEKQQEELRTAVEK---LRRQMLRKSREYDCQILQERMELLQQAHQ 782
Query: 139 EARRAFDGERLRLQQ-EILELKAARK 163
R D ++ +Q + LE K+ RK
Sbjct: 783 RIRDLEDKTDIQKRQIKDLEEKSNRK 808
>gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
Length = 844
Score = 713 bits (1841), Expect = 0.0
Identities = 374/623 (60%), Positives = 485/623 (77%), Gaps = 22/623 (3%)
Query: 1 MSKKG---RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKL 56
MSK+G R+KG+K E A+Q ANE+LRAKLT IQIE QQEKSKV K+ RE+ QE +
Sbjct: 1 MSKRGMSSRAKGDKAEALA-ALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
Query: 57 EREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
RE EQ + ++ELK KLHEEK KELQA+RE L+RQHE E R KIK+ E QRLQA
Sbjct: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
L+ LRDG +KVKT LL+EA+EEA++ F+ E++++QQEI ELK A++Q EEAL+ +QAD
Sbjct: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKL 236
K KAA++R+ Y HQ+E+ RIK+ECER+IRRLM+EIK KDR + LE+ELGVQAG Q+L
Sbjct: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
Query: 237 LLQKEALDEQLVQVKEAERHHSSPKRELP--PGIGDMVELMGVQDQHMDERDVRRFQLKI 294
LQKEALDEQL QV+EA+RH SP+RELP G GD + G +Q +DE+D RRFQLKI
Sbjct: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
AEL+++IRKLEDRN LL++ERNELLKR RE E Q KPL++KNKR+++KNEDL +++RME
Sbjct: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
Query: 355 EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLS- 413
K+K +T+EN+EM+++ ++R +SLNDL ++DE+E++FL+LQ++EQQ++ID+LS
Sbjct: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
Query: 414 -----------LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
LER++LLR ++ R K K PK VVETFFG+DEE+ S SY TD
Sbjct: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
Query: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
RTD+TP TP++DL++ A+EE +LRF QLT EYQALQRAYALLQEQVGGTLDAERE +TR
Sbjct: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
EQLQA++ R QA+IEDLEK L E+GQD KW+EEKQ L R NQ+L+EKI ++E EE +L++
Sbjct: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
Query: 583 EMQDAKDQNELLEFRVLELEVRD 605
E+QDA+DQNELLEFR+LELE R+
Sbjct: 597 EVQDARDQNELLEFRILELEERE 619
Score = 42.7 bits (99), Expect = 0.001
Identities = 71/332 (21%), Positives = 134/332 (40%), Gaps = 51/332 (15%)
Query: 81 TKELQALREGLIRQHEQ-----EAARTAKIKE---GELQRLQATLNVLRDGAADKVKTAL 132
T E QAL+ EQ +A R K +E E+QR QA + L A++ +
Sbjct: 506 TMEYQALQRAYALLQEQVGGTLDAEREVKTREQLQAEVQRAQARIEDLEKALAEQGQDMK 565
Query: 133 LTEAR-------------------EEARRAFDGERLRLQQEILELKAARKQAEEALSNCM 173
E + EEAR + + R Q E+LE + + E S +
Sbjct: 566 WIEEKQALYRRNQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAI 625
Query: 174 QADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQT 233
T D ++ Q + E + ++ + +D + D L E+++ V +T
Sbjct: 626 SFHHTPFVDGKSPLQVY-CEAEGVTDIVVAELMKKLDIL--GDNANLTNEEQVVVIQART 682
Query: 234 QKLLLQK---------EALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE 284
L +K AL ++V ++ + S K L + + + ++H+ E
Sbjct: 683 VLTLAEKWLQQIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILE 742
Query: 285 RDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRE--TEVQLKPLVEKNKRMNKK 342
+ + E + + + LL++E E LK + E + L E++ ++ ++
Sbjct: 743 LEAMLYDALQQEAGAKVAE------LLSEEEREKLKVAVEQWKRQVMSELRERDAQILRE 796
Query: 343 NEDLL----QSIQRMEEKIKNLTRENVEMKEK 370
+LL Q I+ +EE+I+ R+ E++EK
Sbjct: 797 RMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
Score = 36.2 bits (82), Expect = 0.093
Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 31/165 (18%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
EE A L ++ + EK K + L E R+Q + +I EL+A L++ +E
Sbjct: 695 EETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQE 754
Query: 84 LQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRA 143
A L+ + E+E + A ++ K +++E RE
Sbjct: 755 AGAKVAELLSEEEREKLKV---------------------AVEQWKRQVMSELRER---- 789
Query: 144 FDGERLRLQQEILELKAAR-KQAEEALSNCMQADKTKAADLRAAY 187
D + LR + E+L+L R K+ EE + +A K + +L +
Sbjct: 790 -DAQILRERMELLQLAQQRIKELEERI----EAQKRQIKELEEKF 829
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 113 bits (282), Expect = 6e-25
Identities = 138/602 (22%), Positives = 258/602 (42%), Gaps = 80/602 (13%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
++ + Q+ N EL K E Q + RE+LQ KL+RE++ A+ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ--REKLQREKLQREKDMLLAEAF--SL 1498
Query: 73 KAKLHE---------EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K +L E +K L+A + + Q ++ A AK+K+ +L+ L+A + +
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK-QLRDLEAKVKDQEEE 1557
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
++ T + E + + R + ER+R Q E+++ ++ EEA +C + K L
Sbjct: 1558 LDEQAGTIQMLE-QAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
Y+ Q +V R KRE E + L D++ +D EK L +T+ LL + +
Sbjct: 1616 EEEYEDKQ-KVLREKRELEGKLATLSDQVNRRD---FESEKRLRKDLKRTKALLADAQLM 1671
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
+ L ++R + K +L + V+ + E ++ L+I ++
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEES--EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE 363
LE++ + L E+NE+ R E + + L++K+K + L I ++ +++ +E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 364 NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK 423
E++EKL A S ++EFL +Q ++D + R+
Sbjct: 1790 KQELQEKLQALQS-----------------QVEFL------EQSMVDKSLVSRQEA---- 1822
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
K +ET F+ V R + + +E+++ T EE
Sbjct: 1823 ----------KIRELETRLEFERTQVK------------RLESLASRLKENMEKLT--EE 1858
Query: 484 ADLRFCQLTREYQA---LQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDL 539
D R RE + LQR +E++G E EA R + +L+ DL +A + L
Sbjct: 1859 RDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSL 1918
Query: 540 E---KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEF 596
+ KL ++ D + E ++ N+DL+ + + + + KN+++ D + LE
Sbjct: 1919 QADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELED 1978
Query: 597 RV 598
RV
Sbjct: 1979 RV 1980
Score = 73.6 bits (179), Expect = 5e-13
Identities = 134/672 (19%), Positives = 277/672 (41%), Gaps = 131/672 (19%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
VQ++ E++R K E QQ +SK+ K + E +L ++ + R ISEL ++L +
Sbjct: 1249 VQLSEEQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESR----ISELTSELTD 1300
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
E+ A + L+ E R K E++ LQ + L+ +V + EAR
Sbjct: 1301 ERNTGESASQ--LLDAETAERLRAEK----EMKELQTQYDALKKQM--EVMEMEVMEARL 1352
Query: 139 EARRAFDGE----------RLRLQQEILELKAARKQAEEALSNCMQADKT-------KAA 181
+GE RL+ ++ + E+ +K+ ++ + ++ ++ +
Sbjct: 1353 IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLG 1412
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRLMD-------------EIKGKDRVILALEKELGV 228
DL+A + Q + ++K++C+R L D E++ K R + EL
Sbjct: 1413 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQR---RFDSELSQ 1469
Query: 229 QAGQTQKLLLQKEALDEQ----LVQVKEAERHHSSPKRELPPGIGDMV----ELMGVQDQ 280
+ Q+ LQ+E L + L + ++ ++ +V EL + Q
Sbjct: 1470 AHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQ 1529
Query: 281 HM-DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK---- 335
DE + + + ++ +L + ++ E+ DE+ ++ + +++L+ +E+
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEE----LDEQAGTIQMLEQAKLRLEMEMERMRQT 1585
Query: 336 -NKRMNKKNEDLLQSIQRMEEKIKNLT---RENVEMKEK-LSAQASLK-RHTSLNDLSLT 389
+K M ++E++ ++ Q ++K+K + E E K+K L + L+ + +L+D
Sbjct: 1586 HSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1645
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
RD + + LR + + ++ D L + L K+ P K+ + +
Sbjct: 1646 RDFESEKRLRKDLKRTKALLADAQLMLDHL--------KNSAPSKREIAQL--------- 1688
Query: 450 DSETLSETSYNTDRTDRTPATPEEDLDD--------ATAREEADLRFCQLTREYQALQRA 501
L E+ + + E +++D A A+ + + +L RE +Q
Sbjct: 1689 -KNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 502 YALLQEQVGGTLDAEREA----------------------RTREQLQADLLRCQAKIEDL 539
QE + + + A + +++LQ L Q+++E L
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1807
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLE----KIYRLEMEENQLKNEMQ---DAKDQNE 592
E+ +V+K V ++ IR + LE ++ RLE ++LK M+ + +DQ
Sbjct: 1808 EQSMVDK----SLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI 1863
Query: 593 LLEFRVLELEVR 604
E R E R
Sbjct: 1864 AAENREKEQNKR 1875
Score = 41.6 bits (96), Expect = 0.002
Identities = 68/288 (23%), Positives = 119/288 (41%), Gaps = 48/288 (16%)
Query: 333 VEKNKRMNKKNEDL-----------LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
V+KN + NK +D L +Q EE+I+N E +++ KL K
Sbjct: 1221 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLE-----KAEK 1275
Query: 382 SLNDLSLTRD--EQEIEFLRLQVLEQQHVIDD----LSLERERLLRSKRHRGKSLKPPKK 435
N+L L D E I L ++ ++++ + L E LR+++ K L+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEM-KELQTQYD 1334
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
+ + + E +++ + N ++DD A E L++ + RE
Sbjct: 1335 ALKKQMEVMEMEVMEARLIRAAEIN------------GEVDDDDAGGEWRLKYERAVREV 1382
Query: 496 QALQRAYALLQEQVGGTLDAERE-----ARTREQLQADLLRCQAKIEDLEK---LLVEKG 547
++ LQ++ L+ E++ R LQAD Q ++ L+K L +
Sbjct: 1383 DFTKKR---LQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL 1439
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
QD+K E Q + N +L +K R + E +Q E Q K Q E L+
Sbjct: 1440 QDTKLHLEGQQV--RNHELEKKQRRFDSELSQAHEEAQREKLQREKLQ 1485
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 103 bits (258), Expect = 4e-22
Identities = 134/593 (22%), Positives = 252/593 (42%), Gaps = 85/593 (14%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
++ + Q+ N EL K E Q + RE+LQ KL+RE++ A+ L
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ--REKLQREKLQREKDMLLAEAF--SL 1498
Query: 73 KAKLHE---------EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K +L E +K L+A + + Q ++ A AK+K+ +L+ L+A + +
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK-QLRDLEAKVKDQEEE 1557
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
++ T + E + + R + ER+R Q E+++ ++ EEA +C + K L
Sbjct: 1558 LDEQAGTIQMLE-QAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
Y+ Q +V R KRE E + L D++ +D EK L +T+ LL + +
Sbjct: 1616 EEEYEDKQ-KVLREKRELEGKLATLSDQVNRRD---FESEKRLRKDLKRTKALLADAQLM 1671
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
+ L ++R + K +L + V+ + E ++ L+I ++
Sbjct: 1672 LDHLKNSAPSKREIAQLKNQLEES--EFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE 363
LE++ + L E+NE+ R E + + L++K+K + L I ++ +++ +E
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 364 NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK 423
E++EKL A S ++EFL +Q ++D + R+
Sbjct: 1790 KQELQEKLQALQS-----------------QVEFL------EQSMVDKSLVSRQE----- 1821
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
K +ET F+ V R + + +E+++ T EE
Sbjct: 1822 ---------AKIRELETRLEFERTQV------------KRLESLASRLKENMEKLT--EE 1858
Query: 484 ADLRFCQLTREYQ---ALQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDL 539
D R RE + LQR +E++G E EA R + +L+ DL +A + L
Sbjct: 1859 RDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSL 1918
Query: 540 E---KLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKD 589
+ KL ++ D + E ++ N+DL+ ++ + +E++D D
Sbjct: 1919 QADLKLAFKRIGDLQAAIEDEMESDENEDLIN-----SEGDSDVDSELEDRVD 1966
Score = 73.6 bits (179), Expect = 5e-13
Identities = 134/672 (19%), Positives = 277/672 (41%), Gaps = 131/672 (19%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
VQ++ E++R K E QQ +SK+ K + E +L ++ + R ISEL ++L +
Sbjct: 1249 VQLSEEQIRNK----DEEIQQLRSKLEKAEKERNELRLNSDRLESR----ISELTSELTD 1300
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
E+ A + L+ E R K E++ LQ + L+ +V + EAR
Sbjct: 1301 ERNTGESASQ--LLDAETAERLRAEK----EMKELQTQYDALKKQM--EVMEMEVMEARL 1352
Query: 139 EARRAFDGE----------RLRLQQEILELKAARKQAEEALSNCMQADKT-------KAA 181
+GE RL+ ++ + E+ +K+ ++ + ++ ++ +
Sbjct: 1353 IRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLG 1412
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRLMD-------------EIKGKDRVILALEKELGV 228
DL+A + Q + ++K++C+R L D E++ K R + EL
Sbjct: 1413 DLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQR---RFDSELSQ 1469
Query: 229 QAGQTQKLLLQKEALDEQ----LVQVKEAERHHSSPKRELPPGIGDMV----ELMGVQDQ 280
+ Q+ LQ+E L + L + ++ ++ +V EL + Q
Sbjct: 1470 AHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQ 1529
Query: 281 HM-DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK---- 335
DE + + + ++ +L + ++ E+ DE+ ++ + +++L+ +E+
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEE----LDEQAGTIQMLEQAKLRLEMEMERMRQT 1585
Query: 336 -NKRMNKKNEDLLQSIQRMEEKIKNLT---RENVEMKEK-LSAQASLK-RHTSLNDLSLT 389
+K M ++E++ ++ Q ++K+K + E E K+K L + L+ + +L+D
Sbjct: 1586 HSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNR 1645
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
RD + + LR + + ++ D L + L K+ P K+ + +
Sbjct: 1646 RDFESEKRLRKDLKRTKALLADAQLMLDHL--------KNSAPSKREIAQL--------- 1688
Query: 450 DSETLSETSYNTDRTDRTPATPEEDLDD--------ATAREEADLRFCQLTREYQALQRA 501
L E+ + + E +++D A A+ + + +L RE +Q
Sbjct: 1689 -KNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 502 YALLQEQVGGTLDAEREA----------------------RTREQLQADLLRCQAKIEDL 539
QE + + + A + +++LQ L Q+++E L
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL 1807
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLE----KIYRLEMEENQLKNEMQ---DAKDQNE 592
E+ +V+K V ++ IR + LE ++ RLE ++LK M+ + +DQ
Sbjct: 1808 EQSMVDK----SLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRI 1863
Query: 593 LLEFRVLELEVR 604
E R E R
Sbjct: 1864 AAENREKEQNKR 1875
Score = 54.7 bits (130), Expect = 3e-07
Identities = 84/395 (21%), Positives = 172/395 (43%), Gaps = 67/395 (16%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQ-EAKLER 58
M + ++ ++ E + V+ A + + KL ++++ ++E + K LRE+ + E KL
Sbjct: 1579 MERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLAT 1638
Query: 59 EQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLN 118
+Q + SE + + ++TK L A + L+ H + +A + + E+ +L+ L
Sbjct: 1639 LSDQVNRRDFESEKRLRKDLKRTKALLADAQ-LMLDHLKNSAPSKR----EIAQLKNQLE 1693
Query: 119 VLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKT 178
A VK AR+A + E L +I ++ A+ EE LS +Q +K
Sbjct: 1694 ESEFTCAAAVK----------ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSR-LQREKN 1742
Query: 179 KAADLRAAYQAHQDEVHRIKR----ECERDIRRLMD---EIKGKDRVILALEKELGVQAG 231
+ + Q +E+ + + + RD+ ++ D +++ ++ L+++L QA
Sbjct: 1743 EIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKL--QAL 1800
Query: 232 QTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQ 291
Q+Q L++ +D+ LV +EA+ + E R Q
Sbjct: 1801 QSQVEFLEQSMVDKSLVSRQEAKIRELETRLEF-----------------------ERTQ 1837
Query: 292 LKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ 351
+K L S+ +L++ L +ER++ + + E+NKR+ ++ D + +
Sbjct: 1838 VK--RLESLASRLKENMEKLTEERDQRIAAENREK-------EQNKRLQRQLRDTKEEMG 1888
Query: 352 RMEEKIKNLTRENVEMKEKL--------SAQASLK 378
+ K +R+ E++ L S QA LK
Sbjct: 1889 ELARKEAEASRKKHELEMDLESLEAANQSLQADLK 1923
Score = 41.6 bits (96), Expect = 0.002
Identities = 68/288 (23%), Positives = 119/288 (41%), Gaps = 48/288 (16%)
Query: 333 VEKNKRMNKKNEDL-----------LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHT 381
V+KN + NK +D L +Q EE+I+N E +++ KL K
Sbjct: 1221 VQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLE-----KAEK 1275
Query: 382 SLNDLSLTRD--EQEIEFLRLQVLEQQHVIDD----LSLERERLLRSKRHRGKSLKPPKK 435
N+L L D E I L ++ ++++ + L E LR+++ K L+
Sbjct: 1276 ERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEM-KELQTQYD 1334
Query: 436 HVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY 495
+ + + E +++ + N ++DD A E L++ + RE
Sbjct: 1335 ALKKQMEVMEMEVMEARLIRAAEIN------------GEVDDDDAGGEWRLKYERAVREV 1382
Query: 496 QALQRAYALLQEQVGGTLDAERE-----ARTREQLQADLLRCQAKIEDLEK---LLVEKG 547
++ LQ++ L+ E++ R LQAD Q ++ L+K L +
Sbjct: 1383 DFTKKR---LQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAEL 1439
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
QD+K E Q + N +L +K R + E +Q E Q K Q E L+
Sbjct: 1440 QDTKLHLEGQQV--RNHELEKKQRRFDSELSQAHEEAQREKLQREKLQ 1485
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 94.7 bits (234), Expect = 2e-19
Identities = 129/605 (21%), Positives = 259/605 (42%), Gaps = 69/605 (11%)
Query: 38 QQEKSKVGK--LRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQH 95
QQ + K L L+E + + +R K L EK + L++ G + +
Sbjct: 548 QQTNEETAKQILYNYLKEGSTDNDDATKR--------KVNLVFEKIQTLKSRAAGSAQGN 599
Query: 96 EQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI 155
Q T+++K+ Q+ + T+ V +++ L E + + + ER+R E
Sbjct: 600 NQACNSTSEVKDLLEQKSKLTIEVA------ELQRQLQLEVKNQQNIKEERERMRANLE- 652
Query: 156 LELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECER---DIRRLMDEI 212
EL++ + E S Q + +LR + +E+ ++K E E+ +IR L D++
Sbjct: 653 -ELRSQHNEKVEENSTLQQRLEESEGELRK----NLEELFQVKMEREQHQTEIRDLQDQL 707
Query: 213 KGK-DRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDM 271
D + A E + ++LL K+ L + L+ +E E +REL G +
Sbjct: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
Query: 272 VELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKP 331
E + DQ MD+ ++ ++ L + + +LA N + TE+++K
Sbjct: 768 KEEVSSHDQEMDKLK-EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKL 826
Query: 332 LVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENV-------------------------E 366
L E+N+++ ++E+L + + +++ +I++L + E
Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKE 886
Query: 367 MKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHR 426
KE +SA+ +L+ +L++ QE + L ++ E+ + L + + + H
Sbjct: 887 EKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHL 946
Query: 427 GKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADL 486
GK+++ +K + + ++ E ++ ++ R A + L + T E
Sbjct: 947 GKTIEKLQKEMADIVEASRTSTL--ELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKS- 1003
Query: 487 RFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLR-------CQAKIEDL 539
+LT +Q L++E++ A+ EA T+ QL L+ ++ ++D
Sbjct: 1004 ---RLTA--MKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD 1058
Query: 540 EKLLVEKGQDSKWVEEKQL-LIRTNQDLL-EKIYRLEMEENQLKNEMQDAKDQNELLEFR 597
LV++ +D E +L R N DLL E+I R + QL+NE+ + + LE
Sbjct: 1059 RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECD 1118
Query: 598 VLELE 602
+ LE
Sbjct: 1119 KISLE 1123
Score = 86.7 bits (213), Expect = 6e-17
Identities = 136/654 (20%), Positives = 290/654 (44%), Gaps = 101/654 (15%)
Query: 31 TSIQIEFQQEKSK----VGKLRERLQ-EAKLER--EQEQRRHTAYISELKAKLHEEKTKE 83
TS + ++KSK V +L+ +LQ E K ++ ++E+ R A + EL+++ H EK +E
Sbjct: 606 TSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ-HNEKVEE 664
Query: 84 LQALR------EGLIRQHEQEAARTAKIKEG---ELQRLQATLNVLRDGAADKVKTALLT 134
L+ EG +R++ +E + +E E++ LQ L+ + D ++ +A +
Sbjct: 665 NSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD----ELDSAKRS 720
Query: 135 EAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEV 194
E RE+ A E L+ +Q++ +L A+++ E+ L + L+ +H E+
Sbjct: 721 EDREKG--ALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 195 HRIKRECERDIRRLMDEIKGKDRVILALEKELGV----QAGQTQKLLLQKEALDEQLVQV 250
++K + + +++ L + ++ + + L QAG ++ L +E ++ +
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 251 KEAERHHSSPKRELPPGIGDMV--------------------------ELMGVQDQHMDE 284
+E ER + +R++ GD E V + E
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALE 898
Query: 285 RDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNE 344
++ Q +++ ++L ++ ++++ +L + E E + L + +++ K+
Sbjct: 899 NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 345 DLLQSIQ--------RMEEKIKNLTRENVEMKEKL---SAQASLKRHTSL---NDLSLTR 390
D++++ + +++E + RE EM+ +L + +A R T++ +++ L
Sbjct: 959 DIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
Query: 391 DE-------QEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFG 443
+E Q+ + Q+LEQ + DL E E K R + +K + V +
Sbjct: 1019 EELRDYQRAQDEALTKRQLLEQ--TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 444 FDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQR--- 500
+EE +S+ LSE + ++ E L + AR++ + L R+ + L+
Sbjct: 1077 LEEERNNSDLLSERISRS--REQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRII 1134
Query: 501 ----AYALLQEQVGGTLDA---------EREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+Y +E + ++A E E R R LQ R + K+++L + V+
Sbjct: 1135 HLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV-MQVDDE 1193
Query: 548 QDSKWVEEKQLLIRTN------QDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
S ++ QL +R ++ E+I RLE + +L+ E+++ D NE L+
Sbjct: 1194 HLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 94.4 bits (233), Expect = 3e-19
Identities = 147/629 (23%), Positives = 286/629 (45%), Gaps = 78/629 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAK----LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
++ R K E+PE E + +EE + L Q E ++++ K + ERL++ +L+R
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ-RLKR 674
Query: 59 EQEQRRHTAYISELKAKLHEEKTK------ELQALREGLIRQ-------HEQEAARTAKI 105
E E+ R ++E + + E+ K + Q E RQ +QE R +
Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734
Query: 106 KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAF------DGERLRLQQEILELK 159
+E + +R ++ L + A + + EE RR F + + R +Q +
Sbjct: 735 QEEKRRRRESELQWQEEERAHR------QQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 160 AARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRI-KRECERDIRRLMDE--IKGKD 216
R+Q E L +A++ + + R + + E R +RE E++++ L +E ++ ++
Sbjct: 789 PLREQRERQL----RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 217 RVILALEKELGVQAGQTQKLLLQKEALDE----QLVQVKEAERHHSSPKRELPPGIGDMV 272
R E+E G+Q Q ++ Q++ D+ QL + ++ RH K L +
Sbjct: 845 RAQQLQEEEDGLQEDQERRRS-QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 273 ELMGVQDQHM--DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+L+ +++ + +ER+ RR Q + + + ++ LL +ER + ++ RE + +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR-- 961
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
K+K++ +K E LL EE K R E ++K + L++ L R
Sbjct: 962 ----KDKKLQQKEEQLLG-----EEPEK---RRRQEREKKYREEEELQQEEE----QLLR 1005
Query: 391 DEQEIEFLRLQVLEQQH-VIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
+E+E R Q E+Q+ D+L E E+LLR +R + + + +++ E +EE +
Sbjct: 1006 EEREKR--RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQL 1063
Query: 450 -DSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ 508
E + +R R +++ ++ REE + R Q RE Q R LQ++
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQE-EEQLLREEPEKRRRQ-ERERQC--REEEELQQE 1119
Query: 509 VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE 568
L ERE R R++L+ R + +++ E+ L+ + + + +E + R ++
Sbjct: 1120 EEQLLREEREKRRRQELERQ-YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE--- 1175
Query: 569 KIYRLEMEENQLKNEMQDAKDQNELLEFR 597
L+ EE QL E Q+ + Q ++R
Sbjct: 1176 ----LQQEEEQLLREEQEKRRQERERQYR 1200
Score = 90.9 bits (224), Expect = 3e-18
Identities = 140/600 (23%), Positives = 272/600 (45%), Gaps = 72/600 (12%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLEREQEQRRHTAYISELKAKLHEEKTK 82
E+L+ + Q E Q+E+ ++ KL R+ L+ + E EQ+Q+R +L+ K EE+ +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR-LRREQQLRRKQEEERRE 316
Query: 83 ELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR- 141
+ + RE R+ +QE R +++ + +R + L R+ ++ + L E EE R
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLR--REQEEERREQQLRREQEEERRE 374
Query: 142 -RAFDGERLRLQQEILELKAARKQAEEALSNCMQADK--TKAADLRAAYQ---AHQDEVH 195
+ ++LR +Q++ + R++ + ++ ++ + LR Q ++E H
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 196 RIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL---QKEALDEQLVQVKE 252
K E ER +RL E + + R L E+E + +K L Q+E E+ ++++E
Sbjct: 435 EQKHEQERREQRLKRE-QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQHMDER-----DVRRFQLKIAELNSVIRKLEDR 307
ER +RE +L Q++ ++R + R Q ++ + R+ E+R
Sbjct: 494 EERREQQERRE--------QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 308 NTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE-KIKNLTRENVE 366
R +LLKR E ++ + ++ KR ++ D Q ++R EE + + L RE E
Sbjct: 546 -------REQLLKREEEKRLEQERREQRLKREQEERRD--QLLKREEERRQQRLKREQEE 596
Query: 367 MKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRS---K 423
E+ + ++R L ++E+ + L+ + E++ R++LL+S +
Sbjct: 597 RLEQRLKREEVER--------LEQEERREQRLKREEPEEE--------RRQQLLKSEEQE 640
Query: 424 RHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREE 483
R + L+ ++ E +EE E + + +R ++ A E++ ARE
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE----QARER 696
Query: 484 ADLRF----CQLTREYQALQ-RAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIED 538
R QL E A Q + Y+ ++Q G E+E + R + +++L + +
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR-ESELQWQEEERAH 755
Query: 539 LEKLLVEKGQDSKW---VEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
++ E+ +D W EEK R Q L + E E QL+ E + ++Q L E
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKS--ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Score = 84.0 bits (206), Expect = 4e-16
Identities = 136/612 (22%), Positives = 257/612 (41%), Gaps = 73/612 (11%)
Query: 8 KGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEA-KLEREQEQRRHT 66
KG + E D Q+ EL +++ + + K + RER + E E+E R+
Sbjct: 197 KGHETEEFPDEEQLRRREL------LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 67 AYISELKAKLHEE---KTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
+ + + KL EE + +ELQ E L + QE R + +E + QRL+
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR-------- 302
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
++ RR + ER Q+E E + R+Q EE ++ ++ + +
Sbjct: 303 -------------EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+ + Q+E R E+ +RR +E + + ++ + Q + Q+L +++
Sbjct: 350 Q--LRREQEEERR-----EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
EQ ++ ++ R +RE + E + +H ER +R + + E +++
Sbjct: 403 REQQLRREQQLRREQQLRRE--QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 304 LEDRNTLLADERNELLKRSRETEVQ---LKPLVEKNKRMNKKNEDLLQSIQ--RMEEKIK 358
E+ + R + LKR +E E + LK E+ + ++ E L+ Q R E+++K
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERER 418
E ++++L ++ L+R L + E+E + LEQ+ L E+E
Sbjct: 521 R-QEEEERLQQRLRSEQQLRREQEERREQLLKREEE------KRLEQERREQRLKREQEE 573
Query: 419 -----LLRSKRHRGKSLKPPKKHVVETFFGFDE-ESVDSETLSETSYNTDRTDRTPATPE 472
L R + R + LK ++ +E +E E ++ E E + +
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633
Query: 473 EDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
++ R + LR Q R Q L+R +E++ L E E REQ A+ +
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEE--EERLEQRLKREHEEERREQELAEEEQE 691
Query: 533 QAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLE-KIY-RLEMEENQLKNEMQDAKDQ 590
QA+ E++ K + KW Q + + D + K+Y R +E Q + + Q+ K +
Sbjct: 692 QAR----ERI---KSRIPKW----QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 591 NELLEFRVLELE 602
E + E E
Sbjct: 741 RRESELQWQEEE 752
Score = 77.8 bits (190), Expect = 3e-14
Identities = 131/622 (21%), Positives = 247/622 (39%), Gaps = 86/622 (13%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ---------EQRRHTAYISELK 73
+EE RA+ + Q + + + R ++ +LE E EQ R A E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 74 AKLHEEKTKELQALREGLIRQHEQEAAR-----------------TAKIKEGELQRLQAT 116
K + ++ Q E L RQ ++ R T + + E R +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGER----------LRLQQEILELKAARKQAE 166
L + R G +K + + RE R F E LR ++E L+ + ++Q
Sbjct: 216 LELRRKGREEKQQ-----QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ-R 269
Query: 167 EALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226
E Q K + +LR Q + + R++R E+ +RR +E + + + ++E
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRR--EQQLRRKQEEERREQQEERREQQER 327
Query: 227 GVQAGQTQKLLL---QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
Q + ++ L Q+E ++QL + +E ER +RE Q++
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE--------------QEEERR 373
Query: 284 ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKN 343
E+ +RR Q E + R L E+ ++ E QL+ + + ++
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 344 EDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRH-TSLNDLSLTRDEQEIEFLRLQV 402
+ +R E+++K RE E ++ L + +RH L RD++E R
Sbjct: 434 HEQKHEQERREQRLK---REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 403 LEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
LE++ + ++L R + R + ++ +EE + SE +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQE---------EEERLQQRLRSEQQLRRE 541
Query: 463 RTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTR 522
+ +R + + E + R Q RE Q L+R ++Q+ + R+ R +
Sbjct: 542 QEERR---------EQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKREEERRQQRLK 591
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
+ Q + L + K E++E+L E+ ++ + E+ R Q LL+ + E + QL+
Sbjct: 592 RE-QEERLEQRLKREEVERLEQEERREQRLKREEPEEER-RQQLLKSEEQEERRQQQLRR 649
Query: 583 EMQDAKDQNELLEFRVLELEVR 604
E Q+ ++Q E LE R
Sbjct: 650 EQQERREQRLKREEEEERLEQR 671
Score = 75.9 bits (185), Expect = 1e-13
Identities = 130/607 (21%), Positives = 256/607 (42%), Gaps = 63/607 (10%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
K+ + + K + E ++ EE R + + + +F++E+ +L + +E L R++
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDR-KFREEE----QLLQEREEQPLRRQERD 1359
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
R+ EL+ H+E+ ++ + L RQ + +KE + R Q LR
Sbjct: 1360 RKFRE--EELR---HQEQGRKFLEEEQRLRRQERERKF----LKEEQQLRCQEREQQLRQ 1410
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
K + +R+E R F E +Q++ + RK EE + + +
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREE----EQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 183 LRAAYQAHQDEVHRIKREC------------ERDIRRLMDEIKGKDRVILALEKELGVQA 230
+ + + ++HR +R+ ERD + E++ ++ LE+E +
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 231 GQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRF 290
Q Q+ LQ+E +QL + + ++ R+ + + Q ERD R+F
Sbjct: 1527 QQRQRKFLQEE---QQLRRQERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQERD-RKF 1581
Query: 291 QLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSI 350
+L+ +R+ E + DE+ R +E + QL+ ++ R +++E LLQ
Sbjct: 1582 RLE----EQKVRRQEQERKFMEDEQQ---LRRQEGQQQLR---QERDRKFREDEQLLQER 1631
Query: 351 QRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVID 410
+ + + R+ +E + +L Q ++ D +EQ ++ Q L +Q
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 411 DLSLERERLLRSKRHRG--KSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTP 468
E ++L R +R R + + ++ +E F +EE + ET E +R +
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFR-EEEQLRQETEQEQLRRQERYRKI- 1749
Query: 469 ATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQAD 528
EE L REE LR + R+++ ++ +EQ + +++R+ R EQL+
Sbjct: 1750 -LEEEQL--RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQ- 1805
Query: 529 LLRCQAKIEDLEKLLVEKGQDSK--WVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQD 586
E E+ L + +D K W EE+ L Q L ++ R E Q + +
Sbjct: 1806 --------EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857
Query: 587 AKDQNEL 593
+++ EL
Sbjct: 1858 RREEQEL 1864
Score = 75.5 bits (184), Expect = 1e-13
Identities = 144/642 (22%), Positives = 259/642 (40%), Gaps = 102/642 (15%)
Query: 3 KKGRSKGEKPEMETDAVQMANEEL------------RAKLTSIQIEFQQEKSKV-GKLRE 49
K+ R + E+ + D +Q E+L R + + E QQE+ ++ G+ RE
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 50 RLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGE 109
+ +LER+ K E + +E Q LRE ++ QE R + +E E
Sbjct: 1070 TRRRQELERQYR-------------KEEELQQEEEQLLREEPEKRRRQERERQCR-EEEE 1115
Query: 110 LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERL-------RLQQEILELKAAR 162
LQ+ + L LR+ + + L + REE + E+L R +QE+
Sbjct: 1116 LQQEEEQL--LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++ ++ ++ ++ K R ++E+ R KR+ +R DE + D L
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK-----QRYRDEDQRSD---LKW 1225
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQ---- 278
+ E + + K +EQ Q+++++ +++L +G+ E Q
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 279 ----DQHM-DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRS------RETEV 327
D+H +E + R + K A+ RK ++ LL +ER E +R RE E
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRD--RKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 328 QLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSL---- 383
L+ E+ R +++ + R +E+ + E ++ + + LK L
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 384 NDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFG 443
+ L +D Q L +Q E +++ R +R R K L+ ++ E
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER-KFLEEEQQLRQERHRK 1462
Query: 444 FDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYA 503
F EE + E + DR E+ L R+E D +F + Q +R +
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQL----RRQERDRKFREQELRSQEPERKFL 1518
Query: 504 LLQEQVGGTLDAEREARTREQLQAD-LLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRT 562
++Q+ R+ R R+ LQ + LR Q + + + +D K+ EE+QL
Sbjct: 1519 EEEQQL------HRQQRQRKFLQEEQQLRRQERGQQR-----RQDRDRKFREEEQL---- 1563
Query: 563 NQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
R E EE QL + +D K FR+ E +VR
Sbjct: 1564 ---------RQEREEQQLSRQERDRK-------FRLEEQKVR 1589
Score = 75.1 bits (183), Expect = 2e-13
Identities = 137/660 (20%), Positives = 272/660 (41%), Gaps = 90/660 (13%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLR----ERLQEAKLER 58
++ + + + + E Q E + + Q+ +QE+ + +LR E +E +L R
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 59 EQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIK------------ 106
EQE+ R + + E++ + Q LR + EQ+ R +++
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 107 ----------EGELQRLQATLNVLRDGAADKVKTALLTEAREEARR----AFDGERLRLQ 152
+ E +R + L ++ D +K TE E+ RR D E R +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 153 QEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEI 212
+ + + R++ +E ++ ++ + + R Q ++ + + R E+ +RR +E
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS-EQQLRREQEE- 544
Query: 213 KGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMV 272
+++++ E++ Q + Q+L ++E +QL++ +E ER KRE + +
Sbjct: 545 -RREQLLKREEEKRLEQERREQRLKREQEERRDQLLK-REEERRQQRLKREQEERLEQRL 602
Query: 273 ELMGVQDQHMDER-----------DVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKR 321
+ V+ +ER + RR QL +E R+ + R + R + LKR
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE-QQERREQRLKR 661
Query: 322 SRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN-LTRENVEMKEKLSA-QASLKR 379
E E + L +++ ++ E + ++ E+IK+ + + +++ + A Q+ +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 380 HTSLNDLSLTRDEQEIEFLR----LQVLEQQHVIDDLSLERER-------LLRSKRHRGK 428
+ R EQE + R LQ E++ E +R K RG+
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 429 ---SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATARE--- 482
S +PP + E +E + PEE+ + R+
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRF---------------LPEEEEKEQRRRQRRE 826
Query: 483 -EADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEK 541
E +L+F + + Q +RA L +E+ G D ER R++EQ + R Q + E +
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR-RSQEQRRDQKWRWQLEEERKRR 885
Query: 542 ---LLVEKGQDSKWVEEKQLLIRTNQDL----LEKIYRLEMEENQLKNEMQDAKDQNELL 594
L + + +E+QLL ++L EK R E +E Q + E Q +++ +LL
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE-QERQYREEEQLQQEEEQLL 944
Score = 74.7 bits (182), Expect = 2e-13
Identities = 137/638 (21%), Positives = 265/638 (41%), Gaps = 82/638 (12%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQ--EAKLEREQ 60
K+ R + E+ + +Q E+L + + +QE+ K + E LQ E +L RE+
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGE--EPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 61 EQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
++R K E + +E Q LRE ++ QE R + +E Q + L
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQE---ILELKAARKQAEEALSNCMQADK 177
R+ T R+E R + E LQQE +L + +++ +E C + ++
Sbjct: 1068 RE-----------TRRRQELERQYRKEE-ELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+ + + ++ R ++E ER R +E++ ++ +L E E + + ++
Sbjct: 1116 LQQEEEQL---LREEREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKR-RRQELERQY 1170
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE--RDVRRFQLKIA 295
++E L ++ Q+ E+ +RE + ++ + ++ DE R ++Q +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 296 ELNSVIRKLEDRNTLLADERNELLK-------RSRETEVQLKPLVEKNKRMNKKNEDLL- 347
+ N+V D NE + R R+++ L+ L+ + + +++ E
Sbjct: 1231 KENAV----RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 348 ----------QSIQRMEEK-IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIE 396
+ ++R E+K K R++ E K+ L + KR D +EQ ++
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 397 FLRLQVLEQQHVIDDLSLERERLLRSK--RHRGKSLK------PPKKHVVETFFGFDEES 448
Q L +Q ER+R R + RH+ + K ++ E F +E+
Sbjct: 1347 EREEQPLRRQ--------ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 449 VDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQ 508
+ + E DR DR E+ L +R+E D +F + ++ + +R L+E+
Sbjct: 1399 LRCQE-REQQLRQDR-DRKFREEEQQL----SRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 509 VGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD--L 566
+ R+ R EQL E E+ L + +D K++EE+Q L R +D
Sbjct: 1453 QQLRQERHRKFREEEQLLQ---------EREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 567 LEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
E+ R + E + E Q Q +F E ++R
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Score = 70.9 bits (172), Expect = 3e-12
Identities = 136/630 (21%), Positives = 255/630 (40%), Gaps = 88/630 (13%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTK 82
NE+ R +L Q+ +Q + + L QE +REQE+RR + E+ +
Sbjct: 1247 NEQFR-QLEDSQLRDRQSQQDLQHLLGEQQER--DREQERRRWQQRDRHFPEEEQLEREE 1303
Query: 83 ELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREEARR 142
+ +A R Q E++ R + E +R Q T R+ + LL E E+ R
Sbjct: 1304 QKEAKRRDRKSQEEKQLLREER---EEKRRRQETDRKFRE------EEQLLQEREEQPLR 1354
Query: 143 AFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAH-QDEVHRIKREC 201
+ +R ++E+ + RK EE ++ + + L+ Q Q+ +++++
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEE--EQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPK 261
+R R ++ ++R E+E V+ + ++ L++E +QL Q ERH +
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE---QQLRQ----ERHRKFRE 1465
Query: 262 RELPPGIGDMVELMGVQDQHMDERDVRRF-----QLKIAELNSVIRKLEDRNT----LLA 312
E +++ Q H ERD R+F QL+ E + R+ E R+
Sbjct: 1466 EE------QLLQEREEQQLHRQERD-RKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 313 DERNELLKRSRETE-VQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
+E +L ++ R+ + +Q + + + +R ++ +D + R EE+++ E +E+
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF-REEEQLRQ------EREEQQ 1571
Query: 372 SAQASLKRHTSLNDLSLTRDEQEIEFLR-LQVLEQQHVIDDLSLERERLLRSKRHRGKSL 430
++ R L + + R EQE +F+ Q L +Q L ER+R R +
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 431 KPPKKHVVETFFGFDEESVD---SETLSETSYNTDRT---------------------DR 466
+ + H E F EE E + ++ DR DR
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 467 TPATPEEDL------------DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLD 514
E+ L + R+E + +F + + Q ++ QE+ L+
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 515 AEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLE 574
E+ RE+ Q K + E+L E+ + +E R + L R E
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL-----RQE 1806
Query: 575 MEENQLKNEMQDAKDQNELLEFRVLELEVR 604
EE QL+ + +D K + E + ++ E E R
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Score = 49.7 bits (117), Expect = 8e-06
Identities = 71/378 (18%), Positives = 172/378 (45%), Gaps = 43/378 (11%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH 65
+ +G++ + D E+LR + Q+ Q+ K RL+E K+ R++++R+
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF-----RLEEQKVRRQEQERKF 1597
Query: 66 TAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
+L+ + L +E+ ++ + + L + EQ+ R +E + + L+ +
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR----QERDRKFLEEEPQLR 1653
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
R +++ + REE + +GE +L+++ + K ++ + ++ + +
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ------LRRQERER 1707
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRR--LMDEIKGKDRVILALEKELGVQAGQTQKLLL 238
L+ Q + E+ R RE E +R+ ++++ ++R LE+E + Q+L
Sbjct: 1708 KFLQEEQQLRRQELERKFRE-EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Query: 239 Q----KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKI 294
Q K +EQL Q +E ++ S + ++Q ER+ + QL+
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQ----------ESDRKFREEEQLRQEREEQ--QLRP 1814
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ--R 352
+ + R E++ L +E+ + L++ R+ + + + ++ ++ ++L Q + R
Sbjct: 1815 QQRDGKYRWEEEQ--LQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Query: 353 MEEKIKNLTRENVEMKEK 370
+E+ + L E++ ++K
Sbjct: 1873 RQERERKLREEHIRRQQK 1890
Score = 36.6 bits (83), Expect = 0.071
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 2/112 (1%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
++ R + + E+D E+LR + Q+ QQ K E+LQ + E+ Q
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ 114
R Y +E + E+ +E Q L + ++ QE R K++E ++R Q
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQE--RERKLREEHIRRQQ 1889
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 92.0 bits (227), Expect = 1e-18
Identities = 152/660 (23%), Positives = 270/660 (40%), Gaps = 102/660 (15%)
Query: 13 EMETDAVQMANEELRAKLTSIQIE----------FQQEKSKVGKLRERLQEAKLEREQEQ 62
E DA+Q +EL+A+L +Q E Q EK + + + K E ++
Sbjct: 737 EQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGA 796
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAA----RTAKIKEGELQRLQATLN 118
RR E L EK +E A++ G + +QE A + KIKE LQ+
Sbjct: 797 RRLEEGTEETSETL--EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEA 854
Query: 119 VLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNC---MQA 175
RD + K L++E + R+ D E L+QE++++ ++ AE LS +
Sbjct: 855 YRRDATS---KDQLISELKA-TRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQ 910
Query: 176 DKTKAADLRAAYQAHQDEVHRIKR----------------ECERDIRRLMDEIKGKDRVI 219
+ ADL Q+ Q E ++ E +++ ++E++ + R
Sbjct: 911 VRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKA 970
Query: 220 LALEKE----LGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPG-IGDMVEL 274
+ +K+ LG QK + K E V + + +E +G +
Sbjct: 971 ITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQ 1030
Query: 275 MGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL-------LKRSRETEV 327
G D + + R Q AEL +V TLL E E+ L+ SRE +
Sbjct: 1031 GGSSDSSLALHE--RIQALEAELQAVSHS----KTLLEKELQEVIALTSQELEESREKVL 1084
Query: 328 QLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLS----AQASLKRHTSL 383
+L+ +++++ KK I+R+EE K L E K KL+ + A+L+ H S+
Sbjct: 1085 ELEDELQESRGFRKK-------IKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSI 1137
Query: 384 NDLSLTRDEQEIEFLRLQV-----------LEQQHVIDDL--SLERER-LLRSKRHRGKS 429
+ +L + E ++ L LQV + +H++ L SLE+E+ + S + + +
Sbjct: 1138 LETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAA 1197
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATARE-EADLRF 488
K H F S LSE + + + DD RE +
Sbjct: 1198 AKVEAGHNRRHF------KAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEI 1251
Query: 489 CQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQLQADLLRCQAKIEDLEKLL-VEK 546
Q E + LLQ+Q+ L + + E L+ ++ + + +I+ L++ L + +
Sbjct: 1252 AQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTE 1311
Query: 547 GQDSKWVEEKQLLIRTNQDLLEKI-----------YRLEMEENQLKNEMQDAKDQNELLE 595
Q K +E Q L++ + LE + L+ + ++LKN M+ QN+ L+
Sbjct: 1312 QQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLK 1371
Score = 71.6 bits (174), Expect = 2e-12
Identities = 149/683 (21%), Positives = 270/683 (39%), Gaps = 132/683 (19%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
+++ N L +LT Q +EK ++ + ++ L++E + I E K + E
Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQ----IQEAKTMVEE 668
Query: 79 E---KTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT--LNVLRDGAADKVKTALL 133
+ + +E + RE L R + A+ ++++ +L LQ L L+ D +K L
Sbjct: 669 DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728
Query: 134 TE----AREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQA 189
T+ +RE++ A LQ + EL+ E+ + +Q +K L AA QA
Sbjct: 729 TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTIC-LLQNEKII---LEAALQA 784
Query: 190 HQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQ 249
+ K E +R RRL + + + L +EL +++GQ + L + AL +Q+ +
Sbjct: 785 AKSG----KEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
Query: 250 VK----------EAERHHSSPKRELPPGIGD------------MVELMGVQ-DQHMDERD 286
+K EA R ++ K +L + ELM V ++ E +
Sbjct: 841 IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE 900
Query: 287 VRRFQLKIAELNSVIRKLEDRNTLLADERNEL---LKRSRETEVQLKPLVEKNKRMNKKN 343
+ R ++A++ + LE ER+E+ L+ + + Q+ + E N+ + K+
Sbjct: 901 LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI 960
Query: 344 EDLLQSI--------QRMEEKIKNLTRENVEMKEKL------------------------ 371
E+L Q Q+M +LT EMK K
Sbjct: 961 EELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAA 1020
Query: 372 ------------SAQASLKRHTSLNDLS------------LTRDEQEIEFLRLQVLEQQH 407
S+ +SL H + L L ++ QE+ L Q LE+
Sbjct: 1021 DAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESR 1080
Query: 408 VIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRT 467
+ LE E L+ R K +K ++ + + E E T
Sbjct: 1081 ---EKVLELEDELQESRGFRKKIKRLEE---------SNKKLALELEHEKGKLTGLGQSN 1128
Query: 468 PATPEED--LDDATAREEADLRFCQLTREYQAL-------QRAYALLQEQVGGTLDAERE 518
A E + L+ A A+ EADL QL + QA+ R L + + +L+ E+E
Sbjct: 1129 AALREHNSILETALAKREADL--VQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKE 1186
Query: 519 A--RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQ----DLLEKIYR 572
+EQ+ A + + +E + K ++ K+ L++ Q DL + +
Sbjct: 1187 KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGK 1246
Query: 573 LEMEENQLKNEMQDAKDQNELLE 595
E Q + E+ +A+ Q +LL+
Sbjct: 1247 HSQEIAQFQAELAEARAQLQLLQ 1269
Score = 63.5 bits (153), Expect = 5e-10
Identities = 127/644 (19%), Positives = 265/644 (41%), Gaps = 104/644 (16%)
Query: 19 VQMANEE---LRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAK 75
+Q+A E+ L AK+ +Q + + V LR+++ + + +Q Q T S+LKA
Sbjct: 505 LQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKAS 564
Query: 76 LHEEKTKELQALREGLIRQHEQEAARTAKIK-EGELQRLQATLNVLRDGAAD--KVKTAL 132
+ + LQ++R+ Q + A+ A+++ +GE+ +Q + + G + K++
Sbjct: 565 --QAEISSLQSVRQWY--QQQLALAQEARVRLQGEMAHIQVG-QMTQAGLLEHLKLENVS 619
Query: 133 LTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQD 192
L++ E + E+ R+ ++ ++A E A +A DL+ + +
Sbjct: 620 LSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEG 679
Query: 193 EVHRIKR------ECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQ 246
E R++R E+ + ++ + +D+ + AL++E ++L L +EAL +
Sbjct: 680 ERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQE---HLDLMKQLTLTQEALQSR 736
Query: 247 LVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD----------------------- 283
+ + H+ EL +G EL G D
Sbjct: 737 EQSLDALQTHYD----ELQARLG---ELQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
Query: 284 ---ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL----------LKRSRETEVQLK 330
+R RR + E + + KL + + + + L +++ +E +Q K
Sbjct: 790 EELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQK 849
Query: 331 PLVEKNKRMNKKNEDLLQSI----QRMEEKIKNLTRENVEMK-EKLSAQASLKR------ 379
+VE +R + L+ + +R++ ++K L +E +++ EK +A+A L R
Sbjct: 850 VMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVA 909
Query: 380 ---------HTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE--RERLLRSKRHRGK 428
L RDE E LQ ++Q V + E ++++ ++ K
Sbjct: 910 QVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARK 969
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRF 488
++ K+ + G D S E ++ + +E L A+E AD
Sbjct: 970 AITEQKQKMRR--LGSDLTSAQKEMKTKHKAYENAVGILSRRLQEAL---AAKEAADAEL 1024
Query: 489 CQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQ 548
QL + + + A L E++ L+AE +A + + + ++L++++ Q
Sbjct: 1025 GQLRAQGGSSDSSLA-LHERI-QALEAELQAVSHSKTLLE--------KELQEVIALTSQ 1074
Query: 549 DSKWVEEKQL----LIRTNQDLLEKIYRLEMEENQLKNEMQDAK 588
+ + EK L ++ ++ +KI RLE +L E++ K
Sbjct: 1075 ELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEK 1118
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 88.2 bits (217), Expect = 2e-17
Identities = 129/604 (21%), Positives = 254/604 (42%), Gaps = 67/604 (11%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRE------RLQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1150 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1208 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR--RFQLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1325 QEE---TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1489
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 DL-DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L D+ A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1550 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1601
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 585 QDAK 588
+DA+
Sbjct: 1662 EDAR 1665
Score = 88.2 bits (217), Expect = 2e-17
Identities = 143/657 (21%), Positives = 269/657 (40%), Gaps = 89/657 (13%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1319 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1376
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1432
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1602
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1715
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1716 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1770
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1771 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1829 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEP 621
+ E+ R+ +L+ E+ +A + NE + V +++ KL G + F P
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREV------NALKSKLRRGNETSFVP 1938
Score = 75.1 bits (183), Expect = 2e-13
Identities = 124/597 (20%), Positives = 260/597 (43%), Gaps = 91/597 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 900
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 943
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 944 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1000
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1001 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1109
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1168
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1169 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1225 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1282 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEE- 1327
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
R ++ K+ +LE E N L++++ + + + LE + L ++
Sbjct: 1328 ------------TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Score = 72.0 bits (175), Expect = 2e-12
Identities = 102/446 (22%), Positives = 199/446 (44%), Gaps = 58/446 (13%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1088
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1143
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1193
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1246
Query: 581 KNEMQDAKDQNELLEFRVLELEVRDS 606
K E++ K + LE +V EL+ + S
Sbjct: 1247 KQEVEHKKKK---LEAQVQELQSKCS 1269
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/289 (21%), Positives = 124/289 (42%), Gaps = 45/289 (15%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 844 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 895 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 940
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAR---EEADL 486
L+ +K + + +E+ + E A + L+ TA ++ +
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEA---------------ARQKLQLEKVTAEAKIKKLED 985
Query: 487 RFCQLTREYQALQRAYALLQEQVGG-TLDAEREARTREQLQADLLRCQAKIEDLEKLLVE 545
+ + L + LL+E++ T + E + L + ++ I +LE L +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 546 KGQDSKWVEE-KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNEL 593
+ + + +E+ K+ L D E+I L+ + +LK MQ AK + EL
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK--MQLAKKEEEL 1092
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1884
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1885 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1927
Score = 37.4 bits (85), Expect = 0.042
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1859 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1916 AMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 88.2 bits (217), Expect = 2e-17
Identities = 129/604 (21%), Positives = 254/604 (42%), Gaps = 67/604 (11%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRE------RLQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1157 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1215 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR--RFQLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1332 QEE---TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1496
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 DL-DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L D+ A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1557 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1608
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 585 QDAK 588
+DA+
Sbjct: 1669 EDAR 1672
Score = 88.2 bits (217), Expect = 2e-17
Identities = 143/657 (21%), Positives = 269/657 (40%), Gaps = 89/657 (13%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1326 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1383
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1439
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1609
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1722
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1723 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1777
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1778 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1836 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVRDSICCKLSNGADILFEP 621
+ E+ R+ +L+ E+ +A + NE + V +++ KL G + F P
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREV------NALKSKLRRGNETSFVP 1945
Score = 75.1 bits (183), Expect = 2e-13
Identities = 124/597 (20%), Positives = 260/597 (43%), Gaps = 91/597 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 907
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 950
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 951 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1008 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1116
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1175
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1176 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1232 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1289 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEE- 1334
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
R ++ K+ +LE E N L++++ + + + LE + L ++
Sbjct: 1335 ------------TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Score = 72.0 bits (175), Expect = 2e-12
Identities = 102/446 (22%), Positives = 199/446 (44%), Gaps = 58/446 (13%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1095
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1150
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1200
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1253
Query: 581 KNEMQDAKDQNELLEFRVLELEVRDS 606
K E++ K + LE +V EL+ + S
Sbjct: 1254 KQEVEHKKKK---LEAQVQELQSKCS 1276
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/289 (21%), Positives = 124/289 (42%), Gaps = 45/289 (15%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 851 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 902 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 947
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAR---EEADL 486
L+ +K + + +E+ + E A + L+ TA ++ +
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEA---------------ARQKLQLEKVTAEAKIKKLED 992
Query: 487 RFCQLTREYQALQRAYALLQEQVGG-TLDAEREARTREQLQADLLRCQAKIEDLEKLLVE 545
+ + L + LL+E++ T + E + L + ++ I +LE L +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 546 KGQDSKWVEE-KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNEL 593
+ + + +E+ K+ L D E+I L+ + +LK MQ AK + EL
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK--MQLAKKEEEL 1099
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1891
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1892 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1934
Score = 37.4 bits (85), Expect = 0.042
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1866 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1923 AMGREVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 88.2 bits (217), Expect = 2e-17
Identities = 129/604 (21%), Positives = 254/604 (42%), Gaps = 67/604 (11%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRE------RLQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1157 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1215 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR--RFQLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1332 QEE---TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1496
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 474 DL-DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L D+ A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1557 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1608
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 585 QDAK 588
+DA+
Sbjct: 1669 EDAR 1672
Score = 87.0 bits (214), Expect = 5e-17
Identities = 140/642 (21%), Positives = 265/642 (41%), Gaps = 85/642 (13%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1326 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1383
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1439
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1609
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1722
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1723 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1777
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1778 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1836 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1894
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELL--EFRVLELEVR 604
+ E+ R+ +L+ E+ +A + NE + E L+ ++R
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 75.1 bits (183), Expect = 2e-13
Identities = 124/597 (20%), Positives = 260/597 (43%), Gaps = 91/597 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 907
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 908 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 950
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 951 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1007
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1008 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1116
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1175
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1176 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1232 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1288
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1289 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEE- 1334
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
R ++ K+ +LE E N L++++ + + + LE + L ++
Sbjct: 1335 ------------TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Score = 72.0 bits (175), Expect = 2e-12
Identities = 102/446 (22%), Positives = 199/446 (44%), Gaps = 58/446 (13%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1095
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1096 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1150
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1200
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1253
Query: 581 KNEMQDAKDQNELLEFRVLELEVRDS 606
K E++ K + LE +V EL+ + S
Sbjct: 1254 KQEVEHKKKK---LEAQVQELQSKCS 1276
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/289 (21%), Positives = 124/289 (42%), Gaps = 45/289 (15%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 851 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 902 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 947
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAR---EEADL 486
L+ +K + + +E+ + E A + L+ TA ++ +
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEA---------------ARQKLQLEKVTAEAKIKKLED 992
Query: 487 RFCQLTREYQALQRAYALLQEQVGG-TLDAEREARTREQLQADLLRCQAKIEDLEKLLVE 545
+ + L + LL+E++ T + E + L + ++ I +LE L +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 546 KGQDSKWVEE-KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNEL 593
+ + + +E+ K+ L D E+I L+ + +LK MQ AK + EL
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK--MQLAKKEEEL 1099
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1891
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1892 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1934
Score = 37.4 bits (85), Expect = 0.042
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1865
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1866 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1923 AMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 88.2 bits (217), Expect = 2e-17
Identities = 129/604 (21%), Positives = 254/604 (42%), Gaps = 67/604 (11%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRE------RLQE-------AKLEREQEQRRHTAYIS 70
EEL+A L + E Q+ + + K+RE LQE A+ + E+++R +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKT 130
LK +L E T + A ++ L + EQE K + E + +A + +R A V+
Sbjct: 1150 ALKTEL--EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 131 ALLTEAREEARRA----------FDGERLRLQQEILELKAARKQAE---EALSNCMQADK 177
LTE E+ +RA + E L E+ L A+++ E + L +Q +
Sbjct: 1208 --LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
+K +D A D+VH+++ E E + +++E +GK + L Q TQ+LL
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVE-SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR--RFQLKIA 295
++ Q + V R + L + + +E ++H+ +++ + K+
Sbjct: 1325 QEE---TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 296 ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
+ S + LE+ E L ++ E L + R+ ++ +DL+ + +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLE 415
+ NL ++ + + L+ + ++ S DE++ R + ++ LSL
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNIS--------SKYADERD----RAEAEAREKETKALSLA 1489
Query: 416 R--ERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
R E L +K ++ K K + + D+ + L ++ + T E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 474 DL-DDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
+L D+ A E+A LR L QAL+ + E+ D + E + R QLQ L
Sbjct: 1550 ELEDELQATEDAKLR---LEVNMQALKGQF----ERDLQARDEQNEEK-RRQLQRQLHEY 1601
Query: 533 QAKIEDLEKLLVEKGQDSKWVE--------EKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
+ ++ED K K +E + I+ ++ ++++ +L+ + + E+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 585 QDAK 588
+DA+
Sbjct: 1662 EDAR 1665
Score = 87.0 bits (214), Expect = 5e-17
Identities = 140/642 (21%), Positives = 265/642 (41%), Gaps = 85/642 (13%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTA----YISEL 72
D ++ EE R KL ++ + +Q + + L+++L E ++E +Q RH + +S+
Sbjct: 1319 DTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDS 1376
Query: 73 KAKLH---------EEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDG 123
K KL EE K Q E L +Q+E++AA K+++ + RLQ L+ D
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK-NRLQQELD---DL 1432
Query: 124 AADKVKTALLTEAREEARRAFD--------------GERLRLQQEI-------LELKAAR 162
D L E+ +R FD ER R + E L L A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
++A EA + +K A++ + +D+V + E E+ R L +++ + L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
E EL +L + +AL Q + +A + KR +L ++
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR---------QLQRQLHEYE 1602
Query: 283 DERDVRRFQLKIA-----ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
E + R Q +A +L ++ LE + R E +K+ R+ + Q+K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
+++ + + E+K K+L + ++++E L+A ++ L +++E+
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL-------EKEELAE 1715
Query: 398 LRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSET 457
L ++ + D E+ RL + L+ + ++ + + +E LS
Sbjct: 1716 ELASSLSGRNALQD---EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-- 1770
Query: 458 SYNTDRTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQE 507
N T+R+ A E R+ +LR + AL+ A L+E
Sbjct: 1771 --NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 508 QVGGTLDAEREARTREQLQAD--LLRCQAKIEDLEKLLVE-KGQDSKWVEEKQLLIRTNQ 564
QV E++A T+ Q D L ++ED K+ + K Q K + L R +
Sbjct: 1829 QVEQEA-REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE 1887
Query: 565 DLLEKIYRLEMEENQLKNEMQDAKDQNELL--EFRVLELEVR 604
+ E+ R+ +L+ E+ +A + NE + E L+ ++R
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 75.1 bits (183), Expect = 2e-13
Identities = 124/597 (20%), Positives = 260/597 (43%), Gaps = 91/597 (15%)
Query: 29 KLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALR 88
++T + E Q ++ ++ K +ER Q+A+ E ++ +++H + ++E K L E +LQA
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH-SQLTEEKNLLQE----QLQAET 900
Query: 89 EGLIRQHEQEAARTAKIKEGE--LQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDG 146
E E AK +E E L ++A L E E+ +
Sbjct: 901 ELYAEAEEMRVRLAAKKQELEEILHEMEARL-----------------EEEEDRGQQLQA 943
Query: 147 ERLRLQQEILELKAARKQAEEALSNCMQADK----TKAADLRAAYQAHQDEVHRIKRECE 202
ER ++ Q++L+L+ + + EEA +Q +K K L D+ +++ +E
Sbjct: 944 ERKKMAQQMLDLE-EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-- 1000
Query: 203 RDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-VQVKEAERHH---S 258
R+L++E LA E+E +A KL + E++ +L V++K+ E+
Sbjct: 1001 ---RKLLEERISDLTTNLAEEEE---KAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 259 SPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL 318
KR+L D E + + E + + K EL + + +L+D ++N
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKM-QLAKKEEELQAALARLDDE----IAQKNNA 1109
Query: 319 LKRSRETEVQLKPLVE-------KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKL 371
LK+ RE E + L E + K+ DL + ++ ++ ++++ T ++ +++L
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQEL 1168
Query: 372 SAQASLKRHTSLNDLSLTRDEQ-EIEFLRLQVLEQQH--VIDDLSLERERLLRSKRHRGK 428
A KR + L DE+ ++Q + Q+H +++L+ + E+ R+K + K
Sbjct: 1169 RA----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 429 SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADLR 487
+ + +K + E V + E + + + + + D AR E + +
Sbjct: 1225 NKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK 1281
Query: 488 FCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKG 547
+L E +++ +L E G + +L D+ ++++D ++LL E+
Sbjct: 1282 VHKLQNEVESVT---GMLNEAEGKAI----------KLAKDVASLSSQLQDTQELLQEE- 1327
Query: 548 QDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
R ++ K+ +LE E N L++++ + + + LE + L ++
Sbjct: 1328 ------------TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Score = 72.0 bits (175), Expect = 2e-12
Identities = 102/446 (22%), Positives = 199/446 (44%), Gaps = 58/446 (13%)
Query: 188 QAHQDEVHRIK---RECERDIRRL------MDEIKGKDRVILALEKELGVQAGQTQ-KLL 237
QA +DE+ + K ++ E +++ L + E K + L E EL +A + + +L
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
+K+ L+E L +++ ++L M + M ++ ++E + R +L++ ++
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 298 NSV--IRKLEDRNTLLADERNELLKRSRETEVQLKPLV-------EKNKRMNK---KNED 345
+ I+KLED ++ D+ N+L K + E ++ L EK K + K K+E
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 346 LLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQ 405
++ ++ +K + +E ++K KL AS H + DL + +I L++Q+ ++
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDAS-DFHEQIADL-----QAQIAELKMQLAKK 1088
Query: 406 QHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTD 465
+ + + + K + K ++ + H+ + +E +DSE + + D
Sbjct: 1089 EEELQAALARLDDEIAQKNNALKKIRELEGHISDL-----QEDLDSERAARNKAEKQKRD 1143
Query: 466 -----RTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREAR 520
T ED D+TA ++ +LR + +E L++A L E+ EA+
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQ-ELR-AKREQEVTVLKKA---LDEET-----RSHEAQ 1193
Query: 521 TREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
+E Q + E LE+ K K KQ L + N DL ++ L Q
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDK---NKQTLEKENADLAGELRVL----GQA 1246
Query: 581 KNEMQDAKDQNELLEFRVLELEVRDS 606
K E++ K + LE +V EL+ + S
Sbjct: 1247 KQEVEHKKKK---LEAQVQELQSKCS 1269
Score = 45.8 bits (107), Expect = 1e-04
Identities = 62/289 (21%), Positives = 124/289 (42%), Gaps = 45/289 (15%)
Query: 310 LLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
LL R E +++E E+Q K K +K E+ ++ +E+K LT E ++E
Sbjct: 844 LLQVTRQEEEMQAKEDELQ------KTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
+L A+ L E E +R+++ ++ ++++ E E L + RG+
Sbjct: 895 QLQAETEL--------------YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ 940
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAR---EEADL 486
L+ +K + + +E+ + E A + L+ TA ++ +
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEA---------------ARQKLQLEKVTAEAKIKKLED 985
Query: 487 RFCQLTREYQALQRAYALLQEQVGG-TLDAEREARTREQLQADLLRCQAKIEDLEKLLVE 545
+ + L + LL+E++ T + E + L + ++ I +LE L +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 546 KGQDSKWVEE-KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNEL 593
+ + + +E+ K+ L D E+I L+ + +LK MQ AK + EL
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK--MQLAKKEEEL 1092
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 25/175 (14%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K E ++ N+ELR+KL ++ + + KS + L ++ + + + EQE R
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A LK K + K LQ E + + +E A + +L+R
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR------------ 1884
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
L EA EE++R + R +LQ+E+ E ++ EA+ + A K+K
Sbjct: 1885 -------QLEEAEEESQR-INANRRKLQRELDE----ATESNEAMGREVNALKSK 1927
Score = 37.4 bits (85), Expect = 0.042
Identities = 50/253 (19%), Positives = 116/253 (45%), Gaps = 49/253 (19%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAYIS 70
+E D +Q+ + A+ Q + ++E+ L E L + R + E+RR A I+
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEE-----LAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 71 ELKAKLHEEK------------------------------TKELQALREGLIRQHEQEAA 100
+L+ +L EE+ ++ ++ R+ L RQ+++ +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 101 RTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--ARRAFDGERLRLQQEILEL 158
+ +++ + ++T+ L A +++ + EARE+ A ++ + +L++ +L++
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQV 1858
Query: 159 KAARKQAEEALSNCMQADK--TKAADLRAAYQAHQDEVHRI---KRECERDIRRLMDEIK 213
+ RK AE+ QA+K + L+ + ++E RI +R+ +R++ + +
Sbjct: 1859 EDERKMAEQYKE---QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 214 GKDRVILALEKEL 226
R + AL+ +L
Sbjct: 1916 AMGREVNALKSKL 1928
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 3e-17
Identities = 136/637 (21%), Positives = 263/637 (41%), Gaps = 81/637 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQE---AKLEREQEQRRHTAYISELK 73
D ++ EE R KL S+ + +Q + + RE+L+E AK E++ A ++++K
Sbjct: 1312 DTQELLQEENRQKL-SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 74 AKLH---------EEKTKELQALREGLIRQHEQEAARTAKIK------EGELQRLQATLN 118
K+ EE ++LQ EGL ++HE++ A K++ + EL L L+
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 119 VLRDGAADKVKTA-----LLTEARE------EARRAFDGERLRLQQEILELKAARKQAEE 167
R A + K LL E + E R + E + + L L A ++A E
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 168 ALSNCMQADK---TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEK 224
+ + +K T+ DL ++ +D+V + E E+ R L +++ + LE
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSS----KDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 225 ELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDE 284
EL +L + +A+ Q + + S K++ +V + + +++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK------QLVRQVREMEAELED 1600
Query: 285 RDVRRFQLKIA--ELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
+R A +L ++ LE R+E +K+ R+ + Q+K + +
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQV 402
E++L + E+K+K++ E ++++E+L+A KR RDE E
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE-----RDELADE------ 1709
Query: 403 LEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTD 462
+ L+LE +R L ++ + + ++ E + + L NTD
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI----NDRLKKANLQIDQINTD 1765
Query: 463 -RTDRTPATPEEDLDDATAREEADLRF----------CQLTREYQALQRAYALLQEQVGG 511
+R+ A E+ R+ +L+ + AL+ A L+EQ+
Sbjct: 1766 LNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN 1825
Query: 512 TLDAEREA------RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQD 565
ER+A RT ++L+ LL+ + + E+ K Q K + L R ++
Sbjct: 1826 E-TKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY---KDQADKASTRLKQLKRQLEE 1881
Query: 566 LLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE 602
E+ R +L+ E++DA + + + V L+
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLK 1918
Score = 77.4 bits (189), Expect = 4e-14
Identities = 141/637 (22%), Positives = 270/637 (42%), Gaps = 100/637 (15%)
Query: 24 EELRAKLTSIQIEFQ---------------QEKSKVGKLRERLQEA--KLEREQEQRRHT 66
EE K+T + I FQ Q++ K+ +R A KL Q R T
Sbjct: 773 EERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFT 832
Query: 67 AYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAAD 126
L+ EE E+ A E L++ E++ A ++ E E + Q L+
Sbjct: 833 KVKPLLQVSRQEE---EMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 127 KVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAA 186
+ +T L EA EE R ++ L++ +L+A ++ EE + +QA+K K
Sbjct: 890 QAETELCAEA-EELRARLTAKKQELEEICHDLEARVEEEEERCQH-LQAEKKKM------ 941
Query: 187 YQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQ 246
Q + E+ E E ++L E + + LE+E + Q KL +K+ L+++
Sbjct: 942 -QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 247 LVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLED 306
+ + + + + E + + ++ER +RR + + EL RKLE
Sbjct: 1001 IAEFTT----NLTEEEEKSKSLAKLKNKHEAMITDLEER-LRREEKQRQELEKTRRKLEG 1055
Query: 307 RNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE----------K 356
+T L+D+ EL + E ++QL KK E+L ++ R+EE K
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLA----------KKEEELQAALARVEEEAAQKNMALKK 1105
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLER 416
I+ L + E++E L ++ + + L +E+E L+ E + +D + ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDL---GEELEALK---TELEDTLDSTAAQQ 1159
Query: 417 ERLLRSKRHRGKS-LKPPKKHVVETFFGFDEE--SVDSETLSETSYNTDRTDRTPATPEE 473
E LRSKR + + LK + +T +E S+ + E + ++T R A E+
Sbjct: 1160 E--LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEK 1217
Query: 474 DLDDATAREEADLRFCQLTREYQAL-----------QRAYALLQEQVGGTLDAEREARTR 522
A++ + +L E + L ++ A LQE + E R R
Sbjct: 1218 ------AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE---RVR 1268
Query: 523 EQLQADLLRCQAKIEDLEKLLVEK-GQDSKWVEEKQLL---IRTNQDLLE---------- 568
+L + + Q +++++ LL + + SK ++ L ++ Q+LL+
Sbjct: 1269 TELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLS 1328
Query: 569 -KIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
K+ ++E E+N + ++++ ++ LE ++ L +
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Score = 77.4 bits (189), Expect = 4e-14
Identities = 142/686 (20%), Positives = 280/686 (40%), Gaps = 97/686 (14%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---E 59
+ R+K EK + + EEL A T ++ ++ +R QE + + E
Sbjct: 1124 RASRNKAEKQKRDL------GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177
Query: 60 QEQRRHTAYISELKAKLHE---------EKTKELQALREGLIRQHEQEAARTA------- 103
+E + H A I E++ K + E+TK ++A E + E E A
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237
Query: 104 ----------KIKEGELQRLQATLNV---LRDGAADKVK---------TALLTEA-REEA 140
K E +LQ LQ N +R ADKV T LL+++ + +
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 141 RRAFDGERLRLQ-QEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKR 199
+ D L Q Q+ EL + + +LS ++ + + R + ++ H +++
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 200 ECE------RDIRRLMDEIKG----KDRVILALEKEL-GVQAGQTQKLL----------- 237
+ D+++ M++ G + V L+K+L G+ +K+
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
LQ+E LD+ LV + + + +++ + E + ++ +ERD + + E
Sbjct: 1418 LQQE-LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476
Query: 298 N--SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEE 355
S+ R LE+ +++ EL + +++ +++ L+ + K +L +S + +E+
Sbjct: 1477 KALSLARALEE----AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 356 KIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT---------RDEQEIE---FLRLQVL 403
+++ + + E++++L A K +N ++ RDEQ E L QV
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592
Query: 404 EQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDR 463
E + ++D +R + +++ LK + H+ DE L + R
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 464 -TDRTPATPEEDLDDATAREE----ADLRFCQLTREYQALQRAYALLQEQVGGTLDAERE 518
D T A+ EE L A E+ + QL E A +RA Q++ D
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 519 ARTREQLQ-ADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEE 577
+ + L + R +A+I LE+ L E+ +++ + ++ D + LE
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772
Query: 578 NQL-KNEMQDAKDQNELLEFRVLELE 602
Q +N Q + QN+ L+ ++ E+E
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEME 1798
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2031
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2192 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2302
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2363 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2420
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2101
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2102 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2204
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2445 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2044
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2105 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2457
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 2001
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 2002 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2038
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2039 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2080
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2141 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2245
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2291
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2352 QMAQQLAE 2359
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1415
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1416 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1467 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1520
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1521 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1574
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1872 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 601 LE 602
L+
Sbjct: 1930 LK 1931
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2460
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2517
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2518 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2566
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2626 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2683 ARREDVRHY 2691
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1173
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1227
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1228 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1268
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1329 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1687 RELAEQELEKQRQLAE 1702
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2510 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2622
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2679
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2680 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2727
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2035
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2036 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2086
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2196 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2306
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2367 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2424
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2483
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2105
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2106 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2208
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2388
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2448
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2449 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2568 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2048
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2109 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2461
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2617
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1889 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1948 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 2005
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 2006 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2042
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2043 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2084
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2145 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2196
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2249
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2295
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2356 QMAQQLAE 2363
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1419
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1420 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1471 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1524
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1525 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1578
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1638
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1639 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1698
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1875
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1876 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933
Query: 601 LE 602
L+
Sbjct: 1934 LK 1935
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2464
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2521
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2522 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2570
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2630 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2687 ARREDVRHY 2695
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1177
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1178 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1231
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1232 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1272
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1333 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1691 RELAEQELEKQRQLAE 1706
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2514 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2626
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2683
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2684 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2731
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2031
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2032 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2192 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2302
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2363 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2420
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2101
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2102 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2204
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2384
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2444
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2445 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2044
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2105 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2457
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 2001
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 2002 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2038
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2039 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2080
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2141 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2192
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2245
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2291
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2352 QMAQQLAE 2359
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1415
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1416 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1467 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1520
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1521 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1574
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1634
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1635 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1694
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1871
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1872 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 601 LE 602
L+
Sbjct: 1930 LK 1931
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2460
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2517
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2518 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2566
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2626 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2683 ARREDVRHY 2691
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1173
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1227
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1228 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1268
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1329 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1687 RELAEQELEKQRQLAE 1702
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2510 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2622
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2679
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2680 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2727
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 1999
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2000 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2050
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2160 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2270
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2331 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2388
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2447
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2069
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2070 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2172
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2352
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2353 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2412
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2413 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2532 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2012
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2073 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2425
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2581
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1853 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1912 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 1969
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 1970 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2006
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2007 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2048
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2109 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2160
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2213
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2259
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2320 QMAQQLAE 2327
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1383
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1384 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1435 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1488
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1489 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1542
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1602
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1603 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1662
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1839
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1840 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897
Query: 601 LE 602
L+
Sbjct: 1898 LK 1899
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2428
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2485
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2486 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2534
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2594 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2651 ARREDVRHY 2659
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1141
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1142 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1195
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1196 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1236
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1297 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1655 RELAEQELEKQRQLAE 1670
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2478 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2590
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2647
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2648 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2695
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2168
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2169 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2219
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2329 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2439
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2500 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2557
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2616
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2238
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2239 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2285
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2341
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2521
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2522 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2581
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2582 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2181
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2242 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2594
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2750
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 2022 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 2081 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 2138
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 2139 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2175
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2176 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2217
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2278 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2329
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2382
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2428
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2489 QMAQQLAE 2496
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1552
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1553 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1604 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1657
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1658 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1711
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1771
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1772 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1831
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 2008
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 2009 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066
Query: 601 LE 602
L+
Sbjct: 2067 LK 2068
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2597
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2654
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2655 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2703
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2763 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2820 ARREDVRHY 2828
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1310
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1311 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1364
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1365 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1405
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1466 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1824 RELAEQELEKQRQLAE 1839
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2647 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2759
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2816
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2817 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2864
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2009
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2010 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2060
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2169
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2170 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2280
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2341 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2398
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2457
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2079
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2080 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2126
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2182
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2362
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2363 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2422
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2423 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2542 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2022
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2083 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2435
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2591
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1863 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1922 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 1979
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 1980 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2016
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2017 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2058
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2119 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2170
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2223
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2269
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2330 QMAQQLAE 2337
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1393
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1394 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1445 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1498
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1499 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1552
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1612
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1613 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1672
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1849
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1850 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907
Query: 601 LE 602
L+
Sbjct: 1908 LK 1909
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2438
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2495
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2496 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2544
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2604 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2661 ARREDVRHY 2669
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1151
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1152 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1205
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1206 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1246
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1307 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1665 RELAEQELEKQRQLAE 1680
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2488 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2600
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2657
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2658 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2705
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2017
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2018 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2068
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2177
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2178 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2288
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2349 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2406
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2465
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2036
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2037 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2087
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2088 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2134
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2190
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2370
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2371 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2430
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2431 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2550 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2030
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2091 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2385 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2443
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2599
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1871 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1930 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 1987
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 1988 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2024
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2025 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2066
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2127 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2178
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2231
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2277
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2338 QMAQQLAE 2345
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1401
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1402 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1453 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1506
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1507 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1560
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1620
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1621 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1680
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1857
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1858 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915
Query: 601 LE 602
L+
Sbjct: 1916 LK 1917
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2446
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2503
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2504 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2552
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2612 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2669 ARREDVRHY 2677
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1159
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1160 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1213
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1214 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1254
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1314
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1315 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1373
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1673 RELAEQELEKQRQLAE 1688
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2496 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2608
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2665
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2666 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2713
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 87.8 bits (216), Expect = 3e-17
Identities = 133/583 (22%), Positives = 253/583 (43%), Gaps = 73/583 (12%)
Query: 39 QEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQE 98
+E+ + + ER+Q++ E+ R+ A + E++ + K +E + LRE + EQE
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL--KAKVEEARRLRE----RAEQE 2058
Query: 99 AARTAKI-KEGELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILE 157
+AR ++ +E +RLQA +K + + +E ++ E+ L Q E
Sbjct: 2059 SARQLQLAQEAAQKRLQAE---------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE 2109
Query: 158 LKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDR 217
+AAR+ AEEA +QA++ A R +E R+K+ E + ++
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQV-----EEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 218 VILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGV 277
+ E+E +A Q L QK+A D E E+H ++ L EL +
Sbjct: 2165 LRKEAEQEAARRAQAEQAALRQKQAAD------AEMEKHKKFAEQTLRQKAQVEQELTTL 2218
Query: 278 QDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNK 337
+ Q ++E D ++ L+ +++L+ T A +R+++ + VQ++ L +
Sbjct: 2219 RLQ-LEETDHQK-----NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 338 RMNKKNEDLL--------QSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT 389
R+ +N L+ + +Q EK+K + E + A L++ L + L
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ---LAEEDLA 2329
Query: 390 RDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSK---RHRGKSLKPPK----KHVVETFF 442
+ E + + ++ L E E L + K + + + L+ K + + E
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 443 GFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREY-QALQRA 501
GF + ++++E + + + E A A E+A RF + E + L R
Sbjct: 2390 GF-QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRT 2447
Query: 502 YALLQEQVG--GTLDAERE------ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
QE+V TL+ +R+ R RE + A+L R + K++ KLL K ++ + V
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAI-AELEREKEKLQQEAKLLQLKSEEMQTV 2506
Query: 554 EEKQLLIRT----------NQDLLEKIYRLEMEENQLKNEMQD 586
+++QLL T LL++ +E E+ +L+ QD
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549
Score = 86.3 bits (212), Expect = 8e-17
Identities = 151/639 (23%), Positives = 273/639 (42%), Gaps = 73/639 (11%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K + E+ + A E L+AK+ + ++ + + + + QEA +R Q +
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2077
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ A+ + K + ++ ++ Q++ + L + E EAAR A +E E R+QA
Sbjct: 2078 EKAHAFAVQQKEQELQQTLQQEQSVLDQL--RGEAEAARRA-AEEAEEARVQAE------ 2128
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD 182
EA + R+ + ERL+ E E AR QA+ A + + +AA
Sbjct: 2129 -----------REAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAAR 2175
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
A QA + E E+ + ++ K +V E+EL Q ++ QK
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNL 2231
Query: 243 LDEQLVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQ---------HMDERDVRR 289
LDE+L ++K EA R S + EL M EL ++ + D+ + +R
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 290 FQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL- 346
F + AE + + R ++ A E L + + E Q + L EK ++M E
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 347 ----LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEF 397
+ +Q+ +E + R E KE+++ Q + + L R Q E E
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER 2411
Query: 398 LRLQVLE----QQHVIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVD 450
L+L+V E Q +D R++ + K HR + K +V+T + D
Sbjct: 2412 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD 2471
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALL 505
+E L E +R ++ E L + E ++ QL +E QALQ+++ +LL
Sbjct: 2472 AERLREAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
Query: 506 Q-----EQVGGTLDA--EREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE-EKQ 557
Q EQ L+ + E +QL+ + R Q ++E + LV ++++ + E +
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 558 LLIRTNQDLLEKI-YRLEMEENQLKNEMQDAKDQNELLE 595
+R Q+ L+++ + +E L E Q ++Q +LLE
Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Score = 85.9 bits (211), Expect = 1e-16
Identities = 142/636 (22%), Positives = 267/636 (41%), Gaps = 86/636 (13%)
Query: 22 ANEELRAKLTSIQIEFQQEKS---KVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
A E ++ L + + +Q K+ +V +L+ +++EA+ RE+ ++ + +L + +
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL-QLAQEAAQ 2071
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA--ADKVKTALLTEA 136
++ + + ++Q EQE +T + ++ L +L+ R A A++ + EA
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHR 196
+ R+ + ERL+ E E AR QA+ A + + +AA A QA +
Sbjct: 2132 AQSRRQVEEAERLKQSAE--EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 197 IKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVK----E 252
E E+ + ++ K +V E+EL Q ++ QK LDE+L ++K E
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQV----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQH---------MDERDVRRFQLKIAELNSVIRK 303
A R S + EL M EL ++ + D+ + +RF + AE + +
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEK--NKRMNKKNEDL-----LQSIQRMEEK 356
R ++ A E L + + E Q + L EK ++M E + +Q+ +E
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQ-----EIEFLRLQVLE----QQH 407
+ R E KE+++ Q + + L R Q E E L+L+V E Q
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425
Query: 408 VIDDLSLERERL--LRSKRHRGKSLKPPKKHVVETF-FGFDEESVDSETLSETSYNTDRT 464
+D R++ + K HR + K +V+T + D+E L E +R
Sbjct: 2426 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER- 2484
Query: 465 DRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAY-----ALLQ-----EQVGGTLD 514
++ E L + E ++ QL +E QALQ+++ +LLQ EQ L+
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Query: 515 A-------------EREARTREQLQADLLRCQA------------------KIEDLEKLL 543
E + R ++Q++ + R A K E+L++L
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
Query: 544 VEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQ 579
++ Q + + E+ +R LLE+ +R + ++
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
Score = 85.5 bits (210), Expect = 1e-16
Identities = 135/608 (22%), Positives = 248/608 (40%), Gaps = 101/608 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQ 62
R + E + + + E R K T +I ++++++ +LR ++ +R E++
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLI-------RQHEQEA----ARTAKIKEGELQ 111
+H A I E A+L + EL+ ++GL+ RQ E+E A K G+ +
Sbjct: 1912 AQHKADIEERLAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 112 RLQATLNVLRDGAADKVKTALLTE---------AREEARRAFDGERLRLQQEILELKAAR 162
L+ L +R A D +++ E A EE RR + E R+Q+ + + A
Sbjct: 1971 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE-RVQKSLAAEEEAA 2028
Query: 163 KQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILAL 222
+Q + AL +EV R+K + E + RRL + + + L L
Sbjct: 2029 RQRKAAL----------------------EEVERLKAKVE-EARRLRERAEQESARQLQL 2065
Query: 223 EKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM 282
+E QK L +E VQ KE E + + + V DQ
Sbjct: 2066 AQE------AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------------SVLDQLR 2107
Query: 283 DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKK 342
E + R + AE V + E + E E LK+S E + Q + + +K
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 343 NEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRD---EQEIEFLR 399
+ +E + E +++K +A A +++H + +L + EQE+ LR
Sbjct: 2168 EAE--------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR 2219
Query: 400 LQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSY 459
LQ+ E H + L E +RL + + V E F V E LS+
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQ----RSQVEEELFSV---RVQMEELSKLKA 2272
Query: 460 NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREA 519
+ +R ++D +EEA+ + Q+ E L A A+ A
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAE-KMKQVAEEAARLSVA-------------AQEAA 2318
Query: 520 RTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLL-EKIYRLEMEEN 578
R R+ + DL + +A E + K ++ Q++ ++ + L++ ++L E+ RL+ ++
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 579 QLKNEMQD 586
Q+ ++ +
Sbjct: 2379 QMAQQLAE 2386
Score = 79.0 bits (193), Expect = 1e-14
Identities = 146/662 (22%), Positives = 281/662 (42%), Gaps = 94/662 (14%)
Query: 7 SKGEKPEMETDAVQMANE--ELRAK------LTSIQIEFQQEKSKVGKLRERLQEAKLER 58
S +KP++++ + + E +LR LTS I+F E + + ERL E +
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384
Query: 59 EQE-----------QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
E+E QR+ ++ KA+ E + Q ++E ++R+ +EAA A+ ++
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR--EEAAVDAQQQK 1442
Query: 108 GELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEI----LELKAARK 163
+ +Q L LR + ++ +A+ A + RLR+++EI L+L+A +
Sbjct: 1443 ---RSIQEELQQLRQSSEAEI------QAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
Q A +QA + +A + A + Q+E R++R+ + + +R K + V LA
Sbjct: 1494 QRGGAEGE-LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR-----KRQAEVELASR 1547
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ +A + ++ LQ AL+E +Q +EAER + E + +E Q
Sbjct: 1548 VKAEAEAAREKQRALQ--ALEELRLQAEEAERRLRQAEVERARQVQVALETA----QRSA 1601
Query: 284 ERDVRRFQLKIAELNSVI-RKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMN-- 340
E +++ + AE + + R L++ + +A R E +R+++ + E + +
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW 1661
Query: 341 --KKNEDLLQSIQRME------------EKIKNLTRENVEMKEKLSAQASLKRHTSLNDL 386
K NE L +Q E EK K + K QA +R + +L
Sbjct: 1662 QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL 1721
Query: 387 SLTRD------------EQEIEFLRL---QVLEQQHVIDD--LSLERERLLRSKRHRGKS 429
R EQE+ LR Q +Q+ ++++ L+RE +++ +
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT---AREEADL 486
+ K + + E+ S + + R + E ++A A E
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 487 RFCQLTREYQALQRAYA--LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLV 544
R QL E A QRA A +L E++ +A R + + + L +A+ E L +L
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEA---TRLKTEAEIALKEKEAENERLRRLAE 1898
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRL----EMEENQLKNEMQDAKDQNELLEFRVLE 600
++ + +EE+ + D+ E++ +L + E + K ++D Q +E +L
Sbjct: 1899 DEAFQRRRLEEQ--AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956
Query: 601 LE 602
L+
Sbjct: 1957 LK 1958
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 40/309 (12%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+++ R + E+ + ++A +E + +++I+ QQ +LRE + E LERE+E
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE--LEREKE 2487
Query: 62 QRRHTAYISELKAK-----LHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQAT 116
+ + A + +LK++ E+ +E QAL++ + + + R I E E +L+
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI-EQEKAKLE-- 2544
Query: 117 LNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD 176
+ +D A K L E ++ ++ + ER RL + E + + +AEE +
Sbjct: 2545 -QLFQDEVA---KAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV------- 2593
Query: 177 KTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL-GVQAGQTQK 235
+ K +L+ Q + + + E +R +R + ++ + R LA +E+ Q T+
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQR-LREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 236 LLLQKEALDEQLVQVKEAERHHS--------SPKRELPPGIGDMVELMGVQDQH--MDE- 284
L ++ALD EAE HS S +R GI EL + H +DE
Sbjct: 2653 LPNGRDALDG---PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709
Query: 285 ---RDVRRF 290
DVR +
Sbjct: 2710 ARREDVRHY 2718
Score = 54.3 bits (129), Expect = 3e-07
Identities = 119/616 (19%), Positives = 249/616 (40%), Gaps = 90/616 (14%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKE 83
E +A L ++ + + ++ LR+ L+ A+ E+ Q+R H E+ E
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR------------HGERDVE 1200
Query: 84 LQALREGLIRQHEQEAARTAK--IKEGELQRLQATLNVLRDGAADKVKTALLTEAREEAR 141
++ RE + + E+ A A+ +++ EL++L L R+ +AD + A L +AR
Sbjct: 1201 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE-SADPL-GAWLQDAR---- 1254
Query: 142 RAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKREC 201
R Q++I + A QA QA L + H ++V EC
Sbjct: 1255 --------RRQEQIQAMPLADSQAVREQLRQEQA-------LLEEIERHGEKV----EEC 1295
Query: 202 ERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ--KEALDEQLVQVKEAERHHSS 259
+R ++ ++ IK + ++ + +L A +K +Q E++ ++ V ++ ++
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1355
Query: 260 PKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL 319
+ I + + M +++ + E+ + ++AE+ + + K A + +
Sbjct: 1356 LTSQYIKFISETLRRM-EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1414
Query: 320 KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKR 379
+ ++E + +++ V + + + +SIQ ++++ + ++ K + + A R
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 380 HTSLNDLSLTR------------DEQEIEFLRLQVLEQQHVIDDLSLERERLLR-----S 422
++ + R E E++ LR + E + E ERL R S
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 423 KRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEED-------- 474
+R R ++ + E +++ + L E + +R E +
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRA-LQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 475 LDDATAREEADL---------RFCQLTREYQALQRAYALLQEQVGGTLDAEREA-RTREQ 524
L+ A EA+L + QL R Q A A L+E+ + EA R RE+
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653
Query: 525 LQADLLRCQAKIEDLEKLLVE-----------KGQDSKWVEEKQLLIRTNQDLLEKIYR- 572
+ +L R Q K + +L ++ + + K EE + R E+ R
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 573 LEMEENQLKNEMQDAK 588
E+ E +L+ + Q A+
Sbjct: 1714 RELAEQELEKQRQLAE 1729
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 22/230 (9%)
Query: 24 EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE----- 78
E+ +AKL + FQ E +K +LRE Q + + EQE++R A + E + + HE
Sbjct: 2537 EQEKAKLEQL---FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 79 -EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ----ATLNVLRDGAADKVKTALL 133
K +ELQ L + +Q E A +++E +LQ L+ A L + A +V
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLRE-QLQLLEEQHRAALAHSEEVTASQVAA--- 2649
Query: 134 TEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDE 193
T+ R A DG + E RK + + L +A A +L+ Q H
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRL---QEAGILSAEELQRLAQGHTTV 2706
Query: 194 VHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
+RE R + I G ++ A ++L V A ++LL AL
Sbjct: 2707 DELARREDVRHYLQGRSSIAG--LLLKATNEKLSVYAALQRQLLSPGTAL 2754
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 86.7 bits (213), Expect = 6e-17
Identities = 133/630 (21%), Positives = 270/630 (42%), Gaps = 54/630 (8%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
+K K + + D + +LR + T++ Q G +RL+E +++R +E
Sbjct: 1054 QKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKET 1113
Query: 63 RRHTAY---ISELKAKLHEE-----KTKELQALREGLIRQH---EQEAARTAKIKEGELQ 111
H AY + KA + E K EL+ + L +Q E+E + + E EL+
Sbjct: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
Query: 112 RLQATL------NVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQA 165
+ Q + + + A + + L T RE + A + E R++Q +E +A R
Sbjct: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVRE--KEAAERELERVRQLTIEAEAKRAAV 1231
Query: 166 EEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKD-------RV 218
EE L N + + R + H + E+ +LM+E++ K ++
Sbjct: 1232 EENLLN-FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
Query: 219 ILALEKELGVQAGQTQKLLLQKEALD----EQLVQVKEAERHHSSPKRELPPGIGDMVEL 274
I +EK+L Q +K L +K+ ++ ++ +++ R ++ P + +
Sbjct: 1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRA-V 1349
Query: 275 MGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE 334
G+Q +H D++ + ++ EL + RK E L E N L +E + + L +
Sbjct: 1350 TGLQQEH-DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
Query: 335 KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQE 394
K N L ++R ++ K +++ E+ +L+ Q + K ++ + S + +
Sbjct: 1409 KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN-QTTGKAEEAMQEASDLKKIKR 1467
Query: 395 IEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETL 454
L L+ L H L E +R+ R+ K++ +H+ F +E + E L
Sbjct: 1468 NYQLELESL--NHEKGKLQREVDRITRAHAVAEKNI----QHLNSQIHSFRDEK-ELERL 1520
Query: 455 SETSYNTDR-TDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTL 513
+D ++ + E+ L + A +E + + +L E + +L+++V
Sbjct: 1521 QICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKV---- 1576
Query: 514 DAEREARTREQLQADLLRCQAKIED--LEKLLVEKGQDSKWVEE---KQLLIRTNQDLLE 568
E R + + + R QA+ E+ LEK +++ ++ ++ K L TN+ L +
Sbjct: 1577 --EELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHK 1634
Query: 569 KIYRLEMEENQLKNEMQD-AKDQNELLEFR 597
+ + + ++K +D AK QN + EF+
Sbjct: 1635 QTKTEQDFQRKIKCLEEDLAKSQNLVSEFK 1664
Score = 55.1 bits (131), Expect = 2e-07
Identities = 109/572 (19%), Positives = 229/572 (40%), Gaps = 73/572 (12%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERL---------QEAKLEREQEQR 63
E + Q E R K+T IQ ++ V + + QE ++ +E +
Sbjct: 1306 EKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELK 1365
Query: 64 RHTAYISELKAKLHE---EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVL 120
+ ++ K + E T EL AL+ L + +E AR K K L T N L
Sbjct: 1366 QQVDELTAANRKAEQDMRELTYELNALQ--LEKTSSEEKARLLKDK------LDETNNTL 1417
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
R L E +++A + + + L +++ + ++A + S+ + +
Sbjct: 1418 RC-------LKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470
Query: 181 ADL------RAAYQAHQDEVHRIKRECERDIRRLMDEIKG-KDRVILALEKELGVQAGQT 233
+L + Q D + R E++I+ L +I +D L + L + ++
Sbjct: 1471 LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKEL---ERLQICQRKS 1527
Query: 234 QKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLK 293
L Q E EQL+Q +AE+ ++ + L + E + Q ++E + + K
Sbjct: 1528 DHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
Query: 294 IAELNSVIRKLEDRNTLLADERNELLKRSRETEVQ-------LKPLVEKNKRMNKKNEDL 346
+ ++++++ + + E+ + +R ++Q L+ E + K +D
Sbjct: 1588 L-----MMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDF 1642
Query: 347 LQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLT-----------RDEQEI 395
+ I+ +EE + E K+K Q + ++T +L R EQ++
Sbjct: 1643 QRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKV 1702
Query: 396 EFLRLQVLEQQH----VIDDLSLE--RERLLRSKRHRGKSLKPPKKHVVETFFGFDEESV 449
+ + QV E + V D+L L+ E++ K + K E F E+ +
Sbjct: 1703 QLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLM 1762
Query: 450 DSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQV 509
+S+ ++E + R D L +R + + + C+ + Q Q Q
Sbjct: 1763 ESKVITENDISGIRLDFV------SLQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816
Query: 510 GGTLDAEREARTREQLQADLLRCQAKIEDLEK 541
G ++A + ++L+ +L+ + ++E+L++
Sbjct: 1817 GQHMEANHYQKC-QKLEDELIAQKREVENLKQ 1847
Score = 34.3 bits (77), Expect = 0.35
Identities = 50/226 (22%), Positives = 100/226 (44%), Gaps = 20/226 (8%)
Query: 14 METDAVQMAN--EELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLER---EQEQRRHTAY 68
+E D + N E + K I Q K +V L L +K E+ EQ+ + A
Sbjct: 1649 LEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ 1708
Query: 69 ISELKAKL-------HEEKTKELQALREGLIRQHEQ-EAARTAKIKEGELQRLQATLNVL 120
+ EL +L H + +E R+ ++ Q E + ++A+ ++++L + V+
Sbjct: 1709 VQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMES-KVI 1767
Query: 121 RDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKA 180
+ ++ ++ ++E RA + +L + I EL+ +Q E MQ +
Sbjct: 1768 TENDISGIRLDFVS-LQQENSRAQENAKL-CETNIKELERQLQQYREQ----MQQGQHME 1821
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKEL 226
A+ Q +DE+ KRE E +++ +IK + ++ L+ E+
Sbjct: 1822 ANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEI 1867
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 86.3 bits (212), Expect = 8e-17
Identities = 134/603 (22%), Positives = 255/603 (42%), Gaps = 82/603 (13%)
Query: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
+Q EE + Q FQ+ K + ++ L + ++E+E+ + I L+ +L +
Sbjct: 557 LQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQ 616
Query: 79 EK-----TKELQALREGLIRQHEQEAARTAKIKEGELQRL-QATLNVLRDGAADKVKTAL 132
+ T++++ L++ L+R E+ +KE + +R Q RD +K L
Sbjct: 617 ARASAGDTRQVEVLKKELLRTQEE-------LKELQAERQSQEVAGRHRDRELEKQLAVL 669
Query: 133 LTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQD 192
EA + R + + L+LQ+ + +L+ ++A +A +A+ T RAA +
Sbjct: 670 RVEA--DRGRELEEQNLQLQKTLQQLRQDCEEASKA-KMVAEAEATVLGQRRAAVETTLR 726
Query: 193 EVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKE 252
E E R I L ++K ++ E + Q+L +K+ L+E L +E
Sbjct: 727 ETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQE 786
Query: 253 AERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLA 312
E ++ KR L + + +R + R + LN R LE+
Sbjct: 787 EEGSLAAAKRALEARLEEA------------QRGLARLGQEQQTLN---RALEEEG---- 827
Query: 313 DERNELLKRSRETEVQLKPLVEK-----NKRMNKKNEDLLQSIQRMEEKIKNLTRENVEM 367
++ E+L+R + + K L+++ NK + K ED Q++Q+++ ++++ +
Sbjct: 828 -KQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEK--AR 884
Query: 368 KEKLSAQASLKRHTSLNDLS---LTRDEQEIEFLRLQVLEQQHVIDDLSLERERLL---- 420
+E AQ K S + + L+R + EI+ LR + Q D L++E L
Sbjct: 885 REVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQ 944
Query: 421 ----------RSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPAT 470
RS+ R + LK ++ V DEE E L++ N R D+
Sbjct: 945 GLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR-VNRGR-DQVDQL 1002
Query: 471 PEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLL 530
E + + +AR++ + L R+ + L+ A + ++ A L
Sbjct: 1003 RTELMQERSARQDLECDKISLERQNKDLKTRLA--------------SSEGFQKPSASL- 1047
Query: 531 RCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQ 590
+++E +LL E+ Q + EK +L TN+ L K+ L ++ + + D KDQ
Sbjct: 1048 ---SQLESQNQLLQERLQAEE--REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQ 1102
Query: 591 NEL 593
L
Sbjct: 1103 LSL 1105
Score = 80.9 bits (198), Expect = 3e-15
Identities = 119/572 (20%), Positives = 239/572 (41%), Gaps = 53/572 (9%)
Query: 56 LEREQEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEG-ELQRLQ 114
L R+Q++ + +KA ++ G++R+ E+ + + K L+++Q
Sbjct: 298 LLRDQQEAAPPGSVDHMKATIY------------GILREGSSESETSVRRKVSLVLEKMQ 345
Query: 115 ATLNVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQ 174
+ V LT EE +R D E + Q+ +Q EE C +
Sbjct: 346 PLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSR 405
Query: 175 ADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIK----GKDRVILALEKELG-VQ 229
L+ + + E + +E + +++RL+D+ + G + ++ L+ +L VQ
Sbjct: 406 --------LQELLERRKGEAQQSNKELQ-NMKRLLDQGEDLRHGLETQVMELQNKLKHVQ 456
Query: 230 AGQTQK------LLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD 283
+ K LL +E L+E L + E +REL G + E + +DQ +
Sbjct: 457 GPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV- 515
Query: 284 ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKN 343
E +++Q +L ++ + +L ER ++ R + +L+ E+
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF 575
Query: 344 EDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVL 403
+ + ++ ++++ L E EM+E+L + + + + D +++E L+ ++L
Sbjct: 576 QKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELL 635
Query: 404 EQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHV-VETFFGFDEESVD---SETLSETSY 459
Q + +L ER+ + RHR + L+ + VE G + E + +TL +
Sbjct: 636 RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
Query: 460 NTDRTDRTPATPEED---LDDATAREEADLRFCQLTREYQALQRAYALLQEQV---GGTL 513
+ + + E + L A E LR Q E +R L++Q+ G +
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQ--EENDEFRRRILGLEQQLKETRGLV 753
Query: 514 DAER--EARTREQLQADLLRCQAKIEDLEKLL-VEKGQDSKWVEEKQLLIRTNQDLLEKI 570
D EAR R++LQ R +A+ + LE+ L + ++ K+ L ++ +
Sbjct: 754 DGGEAVEARLRDKLQ----RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGL 809
Query: 571 YRLEMEENQLKNEMQDAKDQNELLEFRVLELE 602
RL E+ L +++ Q E+L ELE
Sbjct: 810 ARLGQEQQTLNRALEEEGKQREVLRRGKAELE 841
Score = 37.0 bits (84), Expect = 0.055
Identities = 56/260 (21%), Positives = 107/260 (41%), Gaps = 43/260 (16%)
Query: 2 SKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE 61
+K S+ EK +Q + LR L + Q E + L +RLQ + E E +
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENK 953
Query: 62 QRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLR 121
+R +++ ++L+ L E + R E EL + T+ +L
Sbjct: 954 KRS------------QDDRARQLKGLEEKVSR------------LETELDEEKNTVELLT 989
Query: 122 D------GAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQA 175
D D+++T L+ E AR+ + +++ L+++ +LK A S Q
Sbjct: 990 DRVNRGRDQVDQLRTELMQE--RSARQDLECDKISLERQNKDLK-----TRLASSEGFQK 1042
Query: 176 DKTKAADLRAAYQAHQDEVHRIKRE---CERDIRRLMDEIKGKDRVILALEKELGVQAGQ 232
+ L + Q Q+ + +RE + R+L ++K + + +E E Q
Sbjct: 1043 PSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVK---ELSIQIEDERQHVNDQ 1099
Query: 233 TQKLLLQKEALDEQLVQVKE 252
+L L+ +AL Q+ + +E
Sbjct: 1100 KDQLSLRVKALKRQVDEAEE 1119
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 85.9 bits (211), Expect = 1e-16
Identities = 140/610 (22%), Positives = 269/610 (44%), Gaps = 75/610 (12%)
Query: 14 METDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELK 73
+ +AV A +L L Q + +V KL ERL + + E+ Q HT + +L+
Sbjct: 1236 LSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV---HTE-LQDLQ 1291
Query: 74 AKL---HEEKTK---ELQALREGLIRQHEQEAARTAKIKEGELQRLQAT-----LNVLRD 122
+L EEK+K + +L L+ HE A+ ++++ ELQR++A L ++
Sbjct: 1292 RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE 1351
Query: 123 GAADKVK--TALLTEAREEARRA-FDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
+V+ A + EAR +A A E LR + L+LK ++E + +Q
Sbjct: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL 1411
Query: 180 AADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLL- 238
A Q + + + E E ++ L +I+ LEK+ +Q + L L
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQ-------ELEKQREMQKAALELLSLD 1464
Query: 239 ---QKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIA 295
+ + +D Q Q++E E+ S + LP + + + + VQ + + E + R + +
Sbjct: 1465 LKKRNQEVDLQQEQIQELEKCRSVLEH-LPMAVQEREQKLTVQREQIRELEKDR-ETQRN 1522
Query: 296 ELNSVIRKLEDRNTLLADERNEL--LKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRM 353
L + +LE ++ ++ +R ++ LK+ T L +E+N + + L++ ++
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 354 EEK----IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVI 409
E + +LT + E ++L AQ+S + L R+ QE
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE--------------- 1627
Query: 410 DDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPA 469
R++ ++S+R + + L+ K+H+ + D+E + + D+ R
Sbjct: 1628 ------RDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQK--ERIQVLEDQRTRQTK 1679
Query: 470 TPEEDLDD--ATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQA 527
EEDL+ + RE R +LT + Q +Q E+ G A+R + +L
Sbjct: 1680 ILEEDLEQIKLSLRE----RGRELTTQRQLMQER----AEEGKGPSKAQRGSLEHMKL-- 1729
Query: 528 DLLRCQAKIEDLEKLLVEKGQDSKWVEEKQL--LIRTNQDLLEKIYRLEMEENQLKNEMQ 585
+LR + K + ++ + + Q+ K E+QL L R + + + E E L+ ++Q
Sbjct: 1730 -ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 586 DAKDQNELLE 595
+A++Q EL E
Sbjct: 1789 EAREQGELKE 1798
Score = 74.3 bits (181), Expect = 3e-13
Identities = 138/640 (21%), Positives = 265/640 (41%), Gaps = 74/640 (11%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
E + + ++++ E +LT+ Q + QE+++ GK + Q LE + R E
Sbjct: 1682 EEDLEQIKLSLRERGRELTT-QRQLMQERAEEGKGPSKAQRGSLEHMKLILRD----KEK 1736
Query: 73 KAKLHEEKTKELQALREGLIRQ----HEQ--EAARTAKIKEGELQRLQATLNVLRDGAAD 126
+ + +E ELQ L++ L +Q H + E + +E E+ LQ L R+
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG-- 1794
Query: 127 KVKTALLTEAREEARRAF---DGERLRLQQEILELKAARKQAEE---ALSNCMQADKTKA 180
++K L +EA+RA D E LQQE + + ++ +E AL ++
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRL--MDEIKG--------KDRVILALEKELGVQA 230
+ Q H+++ R++ E + RR+ ++E+ G +++ +LAL+++ QA
Sbjct: 1855 KERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQA 1914
Query: 231 GQ-------TQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELM--GVQDQH 281
+ Q LQ +A+ ++ Q EA R S R E + + H
Sbjct: 1915 QEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
Query: 282 MDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK----PLVEKNK 337
+ + L+ AEL+ R LE L + SR+ E L+ + +++
Sbjct: 1975 AALQGKEQHLLEQAELS---RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 338 RMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEF 397
R + + L Q++ + +E++++ +++ L+ + +L R+E+EI
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 398 LRLQVLEQQHVIDDLSLERERL-LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSE 456
L V E Q + E+E L LR + R P H +E+S+ ++L E
Sbjct: 2092 LHQSVRELQLTL--AQKEQEILELRETQQRNNLEALPHSHKTSP---MEEQSLKLDSL-E 2145
Query: 457 TSYNTDRTDRTPATPEEDLDDATAREEAD---LRFCQLTREYQALQRAYALL-------- 505
+ A + + + RE+A L Q +LQ L
Sbjct: 2146 PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERD 2205
Query: 506 --QEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVE--------E 555
Q+++ L+ R A +E+L + A++ + V+ G+ S VE E
Sbjct: 2206 SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVS-GVEAEPSPDGME 2264
Query: 556 KQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
KQ + + L + + RLE++ ++L+ + E +E
Sbjct: 2265 KQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE 2304
Score = 73.2 bits (178), Expect = 7e-13
Identities = 127/601 (21%), Positives = 258/601 (42%), Gaps = 76/601 (12%)
Query: 13 EMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISEL 72
E E +V E ++Q++ + + K RE L E E + ++ +EL
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAE----KRREALWEKNTHLEAQLQKAEEAGAEL 678
Query: 73 KAKLHEEKTKELQALREGLIRQHEQEAART--------AKIKEGELQR-LQATLNVLRDG 123
+A L + + ++ + ++ +H+QEAA T AK +E L R +Q ++R+
Sbjct: 679 QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREK 738
Query: 124 AADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD-KTKAAD 182
AA +V+ + R++ G L +E+LE Q + ++ + + +
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQG--LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 183 LRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEA 242
+ A + Q EV +K E + + + E R + E+E G+T L QK A
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQE-----GKT-ALEQQKAA 850
Query: 243 LDEQLVQVKEA-ERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVI 301
++++ Q++E E+ S ++EL + + ER+ ++++ E + +
Sbjct: 851 HEKEVNQLREKWEKERSWHQQELAKALESL------------EREKMELEMRLKEQQTEM 898
Query: 302 RKLE-DRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL 360
++ R + L + ETE + L+E + K+ D Q ++R+ + +K
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK-- 956
Query: 361 TRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERE--R 418
+KL Q + T + L ++E L+ +QH D +L+ E
Sbjct: 957 -------VQKLKEQET----TGILQTQLQEAQRE-----LKEAARQHRDDLAALQEESSS 1000
Query: 419 LLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA 478
LL+ K K ++ K +V D + + + + E T +R +++L+
Sbjct: 1001 LLQDKMDLQKQVEDLKSQLVAQ---DDSQRLVEQEVQEKLRETQEYNRI----QKELE-- 1051
Query: 479 TAREEADLRFCQLTREYQ--ALQRAYALLQEQVGGTLDAEREARTREQ---LQADLLRCQ 533
RE+A L + +E + LQ A ++ Q+++ +EA+ ++ Q +LLR +
Sbjct: 1052 --REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 534 AKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNEL 593
K ++ + L Q+++ +EE + T Q L ++ E + QL+ ++ + Q E
Sbjct: 1110 VKEKEADFL----AQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165
Query: 594 L 594
L
Sbjct: 1166 L 1166
Score = 72.4 bits (176), Expect = 1e-12
Identities = 146/690 (21%), Positives = 286/690 (41%), Gaps = 113/690 (16%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQ---IEFQQEKSKVGKLRERLQEAKLEREQEQ 62
R + E E E ++ N EL+ + S Q E Q+E + RERLQE + E +Q
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQ 535
Query: 63 RRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD 122
+ + L+ L E L L+RQ + E E + L ++ N L+
Sbjct: 536 SESLSELITLREAL------ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
Query: 123 GAADKVKTALLTEAREEARRAFDGERLRLQQEILELK------AARKQAEEALSNCMQAD 176
AD A+ A EA +++ L Q++L+L+ +R +A E N +Q D
Sbjct: 590 EVADLRAAAVKLSALNEALAL---DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
Query: 177 KTKA---------------ADLRAAYQAH---QDEVHRIKRECERDIRRLMDEIKGKDRV 218
+A A L+ A +A Q ++ I+ E E ++L + ++
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 219 ILALE---------KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIG 269
LE +E+ +A Q ++ L++++A E +Q E +R + + +
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766
Query: 270 DMVE--LMGVQDQHMDERDVRRFQLKI-------------AELNSVIRKLEDRNTLLADE 314
+++E L Q Q+ +V + QL++ E+ + +L+ + E
Sbjct: 767 ELLESSLFEAQQQN-SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 315 RNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQS---------IQRMEEKIKNLTRENV 365
R+ ++ + E + K +E+ K ++K + L+ Q + + +++L RE +
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM 885
Query: 366 EMKEKLSAQAS-------------LKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDL 412
E++ +L Q + + ++L + L +++ + L +L+ Q + D
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLE-TLLQTQKELADA 944
Query: 413 SLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPE 472
S + ERL + +K K ET + +++ + + R D A E
Sbjct: 945 SQQLERL-------RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD-LAALQE 996
Query: 473 EDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRC 532
E + + + L + A + L++++V L RE + ++Q +L R
Sbjct: 997 ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL---RETQEYNRIQKELERE 1053
Query: 533 QAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAK-DQN 591
+A L L+EK E++LL+ D + + E + L+ +MQ+A+ +Q
Sbjct: 1054 KA---SLTLSLMEK--------EQRLLVLQEADSIR-----QQELSALRQDMQEAQGEQK 1097
Query: 592 EL-LEFRVLELEVRDSICCKLSNGADILFE 620
EL + +L EV++ L+ A +L E
Sbjct: 1098 ELSAQMELLRQEVKEKEADFLAQEAQLLEE 1127
Score = 68.9 bits (167), Expect = 1e-11
Identities = 110/519 (21%), Positives = 221/519 (42%), Gaps = 41/519 (7%)
Query: 91 LIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVK--TALLTEAREEARRAFDGER 148
L+ QE + A + EL +L++ ++ + D+V +ALLT+++++ D E+
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE---DYEK 304
Query: 149 LRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRL 208
+ +KA R+ E ++ + T+ + A+ + E ++ +DI ++
Sbjct: 305 M--------IKALRETVE-----ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV 351
Query: 209 MDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGI 268
M ++ D + E ++ + + D+ L V+ ++L +
Sbjct: 352 M--VEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL 409
Query: 269 GDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQ 328
E + + Q D+ + + L R L ER+ L ++ + + +
Sbjct: 410 AGCQEAVNLLQQQHDQWEEEG------------KALRQRLQKLTGERDTLAGQTVDLQGE 457
Query: 329 LKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMK-EKLSAQASLKRHTSLNDLS 387
+ L ++ + + K E+L Q ++ +E++ L R NVE++ + SAQ + L+
Sbjct: 458 VDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517
Query: 388 LTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEE 447
+ E+ E L +Q + +L RE L S G+ L+ + V E+
Sbjct: 518 VRERERLQEMLMGLEAKQSESLSELITLRE-ALESSHLEGELLRQEQTEVTAA-LARAEQ 575
Query: 448 SVDSETLSETSYNTDRTD-RTPATPEEDLDDATAREEADL--RFCQLTREYQAL-QRAYA 503
S+ + SE + T+ D R A L++A A ++ L + QL E Q++ R A
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 504 LLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTN 563
Q + +D + RE L +A+++ E+ E D + ++E++ I+
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQ-- 693
Query: 564 QDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELE 602
+ L E ++ E QL+ Q+AK Q E+L V E E
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKE 732
Score = 68.9 bits (167), Expect = 1e-11
Identities = 143/680 (21%), Positives = 273/680 (40%), Gaps = 120/680 (17%)
Query: 22 ANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH---TAYISELKAKLHE 78
A+++L ++++ +E+ G L+ +LQEA+ E ++ R+H A + E + L +
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 79 EK---TKELQALREGLIRQHEQEAARTAKIKE------------GELQRLQATLN----- 118
+K K+++ L+ L+ Q + + +++E EL+R +A+L
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 119 ------VLRDGAADKVKTALLTEAREEARRAFDGER--LRLQQEILELKAARKQA----- 165
VL++ AD ++ L+ R++ + A GE+ L Q E+L + K+A
Sbjct: 1064 KEQRLLVLQE--ADSIRQQELSALRQDMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 166 EEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKE 225
E L ++A LRA+ A + + +++ +R +++ LA E++
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLR----LRSTESQLEA-----LAAEQQ 1171
Query: 226 LGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQD------ 279
G QA +L AL + L V E+ S P G + G +
Sbjct: 1172 PGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGP 1231
Query: 280 -------------QHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETE 326
H +D+ + Q L ++KLE+R T E++++ ++ +
Sbjct: 1232 LLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291
Query: 327 VQLKPLVEKNKRMNKKNEDL-------------LQS------IQRME------------- 354
QL E+ + K L LQS +QRME
Sbjct: 1292 RQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE 1351
Query: 355 ---EKIKNLTRENVEMKEKLSAQASLKR--HTSLNDLSLTRDEQEIEFLRLQVLEQQHVI 409
++++L VE + + SA L+ T+ + L L +E E E R Q L++Q
Sbjct: 1352 NLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ--- 1408
Query: 410 DDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPA 469
+L + + + L+ ++ VET G +E + + + D
Sbjct: 1409 GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKR 1468
Query: 470 TPEEDLDDATAREEADLRFCQLTREY-----QALQRAYALLQEQVGGTLDAEREARTREQ 524
E DL +E L C+ E+ Q ++ + +EQ+ L+ +RE + R
Sbjct: 1469 NQEVDLQQEQIQE---LEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRETQ-RNV 1523
Query: 525 LQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEM 584
L+ LL + K + +E ++GQ ++ L +L E +++E ++ +K
Sbjct: 1524 LEHQLLELEKKDQMIES---QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580
Query: 585 QDAKDQNELLEFRVLELEVR 604
+ Q L L+LE R
Sbjct: 1581 GQRETQRVALTHLTLDLEER 1600
Score = 45.1 bits (105), Expect = 2e-04
Identities = 74/327 (22%), Positives = 131/327 (40%), Gaps = 42/327 (12%)
Query: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKL 76
DA Q + +L L + E Q + + + ++LQ+A +R++E R L+ L
Sbjct: 2006 DACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSL 2065
Query: 77 HEEKTKELQALREGLIRQHEQEAAR-----------TAKIKEGELQRLQATLNVLRDGAA 125
+ + + ++ L ++ E+E R T KE E+ L+ T +
Sbjct: 2066 AQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET---QQRNNL 2122
Query: 126 DKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQA--------EEALSNCMQADK 177
+ + + T EE D RLQ+E+ L+AA +Q E+A + +
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 178 TKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLL 237
TKA+ A + ++R+ E+ +RL DE++ R ALEKE G T
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQ--QRLQDELELTRR---ALEKERLHSPGATSTAE 2237
Query: 238 LQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAEL 297
L EQ VQ+ E + P + G++ Q +R + Q +A L
Sbjct: 2238 LGSRG--EQGVQLGEVSGVEAEPSPD------------GMEKQSWRQR-LEHLQQAVARL 2282
Query: 298 NSVIRKLEDRNTLLADERNELLKRSRE 324
+L+ N L ++ + R+
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRK 2309
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 85.5 bits (210), Expect = 1e-16
Identities = 132/617 (21%), Positives = 264/617 (42%), Gaps = 76/617 (12%)
Query: 17 DAVQMANEELRAKLT-SIQI-EFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
D ++ EE R KL S +I + ++EK+ + + +E +EA+ E++ + +++ K
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 75 KLH---------EEKTKELQALREGLIRQHEQEAARTAKIK------EGELQRLQATLNV 119
K+ EE K+L E L ++ E++A K++ + EL L L+
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 120 LRDGAADKVKTA-----LLTEARE------EARRAFDGERLRLQQEILELKAARKQAEEA 168
R A++ K LL E + E R + E + + L L A ++A EA
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 169 LSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGV 228
+ +K AD+ + +D+V + E E+ R L +++ + LE EL
Sbjct: 1499 KEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 229 QAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVR 288
+L + +A+ Q + + + K+ L I + EL + +R +
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRELEAELEDERKQRALA 1615
Query: 289 RFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQ 348
K E++ ++ LE + R+E++K+ R+ + Q+K + + +++
Sbjct: 1616 VASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 349 SIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHV 408
+ E+K+K+L E ++++E+L++ +RH EQE + L ++
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHA----------EQERDELADEITNSASG 1723
Query: 409 IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTP 468
L E+ RL + + + +EE + E L++ T T +
Sbjct: 1724 KSALLDEKRRL--------------EARIAQLEEELEEEQSNMELLNDRFRKT--TLQVD 1767
Query: 469 ATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQAD 528
E + +A +++D QL R+ + L+ A LQ E E + + +A
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELK---AKLQ---------ELEGAVKSKFKAT 1815
Query: 529 LLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEE---NQLKNEMQ 585
+ +AKI LE+ L ++ ++ +L+ RT + L E ++E E +Q K +M+
Sbjct: 1816 ISALEAKIGQLEEQLEQEAKER--AAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873
Query: 586 DAKDQNELLEFRVLELE 602
A + + L+ ++ E E
Sbjct: 1874 KANARMKQLKRQLEEAE 1890
Score = 82.4 bits (202), Expect = 1e-15
Identities = 136/677 (20%), Positives = 292/677 (43%), Gaps = 109/677 (16%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYI 69
E+ + ET+ A EE+RA+L + + E ++ + E +E + E+++ A+I
Sbjct: 894 EQLQAETELFAEA-EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952
Query: 70 SELKAKLHEE-----KTKELQALREGLIRQHEQE----------------------AART 102
+L+ +L EE K + + E I++ E+E A +
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 103 AKIKEGE-----LQRLQATLNVLRDGAADKVKTALLT-EAREEARRAFDGERLRLQQEIL 156
+++ E E L +++ V+ +++K T + E+A+R DGE LQ +I
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 157 ELKA--------ARKQAEEALSNCMQAD----------------KTKAADLRAAYQ---A 189
EL+A K+ EE + D + + A+L+ ++ A
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 190 HQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQL-- 247
+++ + KR+ ++ L E++ A ++ ++ + Q++ K+AL+E+
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE---LRTKREQEVAELKKALEEETKN 1189
Query: 248 --VQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD--ERDVRRFQLKIAELNSVIRK 303
Q+++ + H++ EL + +++ E D + ++ L V +
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 304 LEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRE 363
E + L + EL + E + L EK ++ + +++ ++ E+K ++
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 364 NVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDL--SLERERL-L 420
++ +L L + + L+L+ +++E + + EQQ ++ +LE++ L L
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369
Query: 421 RSKRHRGK-----------SLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPA 469
+S+ K SL+ KK +++ D E++ S+ L E + D+ ++T
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLK-----DAEAL-SQRLEEKALAYDKLEKTKN 1423
Query: 470 TPEEDLDDATA-----------REEADLRFCQLTREYQALQRAYALLQEQVGGTLDAERE 518
+++LDD T E+ +F QL E +++ YA +++ AE E
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR------AEAE 1477
Query: 519 ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEEN 578
AR +E L R A E LE + Q+ + + + L+ + D+ + ++ LE +
Sbjct: 1478 AREKETKALSLAR--ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 579 QLKNEMQDAKDQNELLE 595
L+ ++++ + Q E LE
Sbjct: 1536 ALEQQVEEMRTQLEELE 1552
Score = 69.7 bits (169), Expect = 8e-12
Identities = 117/567 (20%), Positives = 245/567 (43%), Gaps = 127/567 (22%)
Query: 127 KVKTALLTEAREEARRAFDGERLRLQQ-------EILELKAARKQAEE---ALSNCMQAD 176
KVK L +EE +A D E L++++ E+ E++ +Q E L+ +QA+
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 177 K---TKAADLRAAYQAHQDEVHRIKRECERDIRR-------LMDEIKGKDRVILALEKEL 226
+A ++RA A + E+ I + E + L +E K I LE++L
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 227 GVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMD-ER 285
+ G QKL L+K + ++ +++E E++ ++DQ+ +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEE--------------------EILLLEDQNSKFIK 999
Query: 286 DVRRFQLKIAELNSVIRKLEDRNTLLADERN-------ELLKRSRETEVQLKPLVEKNKR 338
+ + + +IAE +S + + E++ LA RN +L +R ++ E + L + ++
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 339 MNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDE--QEIE 396
++ + DL I ++ +I L + + +E+L Q +L R +D +L ++ + +
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEEL--QGALARG---DDETLHKNNALKVVR 1114
Query: 397 FLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSE 456
L+ Q+ E Q + R + + KR + L+ K + E+++D+ T ++
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL--------EDTLDT-TAAQ 1165
Query: 457 TSYNTDRTDRTPATPEEDLDDATAREEADLR---------FCQLTREYQALQRAYALLQE 507
T R ++ A ++ L++ T EA ++ +L+ + + +R A L++
Sbjct: 1166 QELRTKR-EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 508 QVGG----------------TLDAEREARTREQLQADLLRCQAKIEDLEKLLVEKGQ--- 548
G + AE E + R++L A + AK+ + ++L VE +
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHK-RKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283
Query: 549 ------------------------------DSKWVEEKQLL---IRTNQDLLEKIYRLEM 575
+S+ + ++LL R +L +I +LE
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343
Query: 576 EENQLKNEMQDAKDQNELLEFRVLELE 602
E+N L+ + ++ ++ + LE +VL L+
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Score = 39.7 bits (91), Expect = 0.008
Identities = 40/166 (24%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQE-KSKVGKLRERLQEAKLEREQEQRR 64
RS +K + ++ N+EL+AKL ++ + + K+ + L ++ + + + EQE +
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGA 124
A + + E+K KE + Q E E + KE ++++ A + L+
Sbjct: 1837 RAA--ANKLVRRTEKKLKE-------IFMQVEDERRHADQYKE-QMEKANARMKQLK--- 1883
Query: 125 ADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALS 170
L EA EEA RA + R +LQ+E+ + A + +S
Sbjct: 1884 ------RQLEEAEEEATRA-NASRRKLQRELDDATEANEGLSREVS 1922
Score = 36.6 bits (83), Expect = 0.071
Identities = 49/269 (18%), Positives = 112/269 (41%), Gaps = 54/269 (20%)
Query: 10 EKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ--------- 60
E+ D + ++E KL S++ E Q + ++ + A+ ER++
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 61 --------EQRRHTAYISELKAKLHEEKTK--------------------ELQA------ 86
E+RR A I++L+ +L EE++ EL A
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQ 1781
Query: 87 ----LREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEAREE--A 140
R+ L RQ+++ A+ +++ + +AT++ L + +++ L EA+E A
Sbjct: 1782 KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL-EAKIGQLEEQLEQEAKERAAA 1840
Query: 141 RRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRI--- 197
+ +L++ ++++ R+ A++ M+ + L+ + ++E R
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQ-YKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 198 KRECERDIRRLMDEIKGKDRVILALEKEL 226
+R+ +R++ + +G R + L+ L
Sbjct: 1900 RRKLQRELDDATEANEGLSREVSTLKNRL 1928
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 84.0 bits (206), Expect = 4e-16
Identities = 137/628 (21%), Positives = 257/628 (40%), Gaps = 103/628 (16%)
Query: 26 LRAKLTSIQIEFQQEKSKVGKLRERLQEAKLE-----REQEQR----RHTAYISELKAKL 76
L ++LT++ QQ+ ++ L+++ +E + + ++QEQ RH K
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 77 HEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEA 136
E++ KE+ +E + H Q+ A A+ +E L+ A L L A +K K A L
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLE--ALEKEKAAKLE-- 618
Query: 137 REEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQAD---KTKAADLRAAYQAHQDE 193
LQQ++ AR A+ +++ + K +L+A + + E
Sbjct: 619 -------------ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 194 VHRIKRE-CERDIRRLMDEIKGKDRVILALEKELGVQAGQTQK--LLLQKEALDEQLVQV 250
H + + E +++ ++ K ++ +A EK+ + Q K L + K +L+E+ +
Sbjct: 666 QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA 725
Query: 251 KEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTL 310
+A EL +VE + + ++E R L+ A L + + +
Sbjct: 726 ADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLE-ARLQQLGEAHQAETEV 784
Query: 311 LADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQ-----------SIQRMEEKIKN 359
L E E + E + + LV++ ++ ED Q + ++E+ +
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLR------LQVLEQ-----QHV 408
+E E KEK+ A ++ H ++L ++R + E+ L LQ +++ Q +
Sbjct: 845 ARQELQEAKEKV---AGIESH---SELQISRQQNELAELHANLARALQQVQEKEVRAQKL 898
Query: 409 IDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTP 468
DDLS +E++ + + + +K G +E+ E + E + DR
Sbjct: 899 ADDLSTLQEKMAATSKEVARLETLVRK------AGEQQETASRELVKEPARAGDR----- 947
Query: 469 ATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQAD 528
PE E+ +FC QA++R +AE+ E+L+A
Sbjct: 948 -QPE------WLEEQQGRQFCSTQAALQAMER-------------EAEQMGNELERLRAA 987
Query: 529 LLRCQAKIEDLEKLLVEKGQDSKWVEE-KQLLIRTNQDL-LEKIYRLEME---ENQLKNE 583
L+ Q + ++ E+GQ + V Q R DL LEK R E+E +N L +
Sbjct: 988 LMESQGQQQE------ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 584 MQDAKDQNELLEFRVLELEVRDSICCKL 611
+ E L + E E +D KL
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKL 1069
Score = 77.0 bits (188), Expect = 5e-14
Identities = 135/623 (21%), Positives = 270/623 (43%), Gaps = 68/623 (10%)
Query: 6 RSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRH 65
+ K K E+ +Q+ANE + TS+ + Q+EK+++ + E LQ QEQ
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVT-QAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 66 TAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAA 125
A ++EL+ +L E+ K + +E + ++ +Q + +KE L+ + +L + AA
Sbjct: 670 QAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQLQALKE-SLKVTKGSLEEEKRRAA 726
Query: 126 DKV--KTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADL 183
D + + ++E + E R + + R ++E+ E +A RK E L +A + + L
Sbjct: 727 DALEEQQRCISELKAETRSLVE-QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
Query: 184 RAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEAL 243
R H + ECE+ ++ + ++R + ++E A ++L+ KE
Sbjct: 786 RRELAEAMAAQHTAESECEQLVKEV---AAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842
Query: 244 DEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRK 303
++ +++EA +E GI EL + Q+ ++ +A +++
Sbjct: 843 EKARQELQEA--------KEKVAGIESHSELQISRQQN----ELAELHANLARALQQVQE 890
Query: 304 LEDRNTLLADERNELLKRSRETE---VQLKPLVEK-NKRMNKKNEDLLQSIQRMEEKIKN 359
E R LAD+ + L ++ T +L+ LV K ++ + +L++ R ++
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERER- 418
E + ++ S QA+L+ + + E+E LR ++E Q + ++ER
Sbjct: 951 WLEEQ-QGRQFCSTQAALQ----AMEREAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
Query: 419 LLRSKRHRGK-----SLKPPKKHVVETFF--GFDEESVDSETLSETSYNTDRTDRTPATP 471
+ R + RG+ +L+ + +E +E+ V+ TL E + A
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH--------ALT 1057
Query: 472 EEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQV---------GGTLDAEREARTR 522
E++ D + L Q+ +E + L++ L+EQ+ G +E RT
Sbjct: 1058 EKEGKDQELAKLRGLEAAQI-KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT- 1115
Query: 523 EQLQADLLRCQAKIEDLEKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKN 582
E L +A++ LE+ ++ + + +E R ++ E+ LE + QL+
Sbjct: 1116 EPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASR--AERDSALETLQGQLEE 1173
Query: 583 EMQD--------AKDQNELLEFR 597
+ Q+ A Q EL FR
Sbjct: 1174 KAQELGHSQSALASAQRELAAFR 1196
Score = 76.6 bits (187), Expect = 6e-14
Identities = 143/655 (21%), Positives = 258/655 (39%), Gaps = 98/655 (14%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLERE- 59
M +G+ + E+ + E + ++ E RA Q + EK+ +L RLQ A E+
Sbjct: 989 MESQGQQQEERGQQEREVARLTQERGRA-----QADLALEKAARAELEMRLQNALNEQRV 1043
Query: 60 -----QEQRRHTAYISELKAK-------LHEEKTKELQALREGLIRQHEQEAARTAKIKE 107
QE H E K + L + KEL+ LR+ + + EQ A + +
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 108 G----------------ELQRLQATLNVLRDGAADKVKTALLTEAREEARRAFDGER--- 148
G +L+ L+A ++ L + + A E EA RA ER
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163
Query: 149 LRLQQEILELKAARK-QAEEALSNCMQ---ADKTKAADLRAAYQAHQDEVHRIKRECERD 204
L Q LE KA ++ AL++ + A +TK D A + +V R ++E ER
Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAER- 1222
Query: 205 IRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKREL 264
K+ +I +LE+E+ + + +L+KE ++L ++ AE S E
Sbjct: 1223 ----------KNSLISSLEEEVSI----LNRQVLEKEGESKELKRLVMAESEKSQKLEE- 1267
Query: 265 PPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRE 324
+ L+ + R R E+ S+ + E + + R EL ++
Sbjct: 1268 ------RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 325 TEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMK---EKLSAQ--ASLKR 379
E + L ++ +K E L ++Q + L E + K ++L A+ A+ KR
Sbjct: 1322 AEELGQELKAWQEKFFQK-EQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR 1380
Query: 380 HTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVE 439
H L + +Q LR ++L Q + +L R+++ +R + L+ K E
Sbjct: 1381 HRE----ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQER-TAQQLRAEKASYAE 1435
Query: 440 TFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDD---------ATAREEADLRFCQ 490
+ E +R + E +LD A R +A+ R +
Sbjct: 1436 QLSML--KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE 1493
Query: 491 LTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQA------------KIED 538
+ RE Q+ R ++ + G E R R Q + L Q ++E+
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 539 LEKLLVEKGQDSKWVEEKQLLIRT-NQDLLEKIYRLEMEENQLKNEMQDAKDQNE 592
L K L + Q SK ++K ++ + ++ RL+ + N+L+ ++ + E
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE 1608
Score = 53.9 bits (128), Expect = 4e-07
Identities = 103/454 (22%), Positives = 187/454 (41%), Gaps = 73/454 (16%)
Query: 22 ANEELRAKLTSIQIEFQQEKSKVGKLRER---LQEAKLEREQEQRRHTAYISELKAKLHE 78
A +E +A++ + E +++ S + L E L LE+E E + ELK +
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK-------ELKRLVMA 1257
Query: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTA---LLTE 135
E K Q L E L + A+ +A+ E L+ + LR+ A+K + A L E
Sbjct: 1258 ESEKS-QKLEERLRLLQAETASNSARAAERS-SALREEVQSLRE-EAEKQRVASENLRQE 1314
Query: 136 AREEARRAFD-GERLRLQQEIL---ELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQ 191
+A RA + G+ L+ QE E + Q E + + ++ A L QA Q
Sbjct: 1315 LTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQ 1374
Query: 192 DEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGV----------QAGQTQKLLLQKE 241
+ RE ++ + G +L ++ELG Q Q+L +K
Sbjct: 1375 AAAEKRHRE---ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKA 1431
Query: 242 ALDEQLVQVKEAERHHSSPKRELPPGIGDM---------VELMGVQDQHMDERDVRRF-- 290
+ EQL +K+A + R G+G+ VEL +++++ E R
Sbjct: 1432 SYAEQLSMLKKAHGLLAEENR----GLGERANLGRQFLEVELDQAREKYVQELAAVRADA 1487
Query: 291 QLKIAELN----SVIRKLE--------------DRNTLLADERNELLKRSRETEVQLKPL 332
+ ++AE+ S R+LE + +ER +L + + EV +
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547
Query: 333 VEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDL--SLTR 390
++ + ++KK D Q+ + ++K+K + + E S Q + + LN+L L++
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE-----SQQEAQRLQAQLNELQAQLSQ 1602
Query: 391 DEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKR 424
EQ E +LQ+ + + D + + L R
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR 1636
Score = 53.9 bits (128), Expect = 4e-07
Identities = 100/444 (22%), Positives = 186/444 (41%), Gaps = 92/444 (20%)
Query: 15 ETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQE----QRRHT---A 67
E + ++A+E LR +LTS Q E +E +G+ + QE ++EQ Q HT A
Sbjct: 1300 EAEKQRVASENLRQELTS-QAERAEE---LGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 68 YISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEG---ELQRLQATLNVL---R 121
+SEL H ++LQA + ++H +E ++ + G EL R Q L L R
Sbjct: 1356 LVSELLPAKH--LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 122 DGAADKVKTALLTEARE------------------EARRAFDGERLRLQQEILELKAARK 163
A++ +TA A + E R GER L ++ LE+
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL-GERANLGRQFLEV----- 1467
Query: 164 QAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
+ ++A +Q + A +RA + EV R + R++ + + +G +L
Sbjct: 1468 ELDQAREKYVQ----ELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLE-- 1521
Query: 224 KELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHM- 282
+ Q+ +++ L Q+ Q++ +R + EL + D + VQ Q +
Sbjct: 1522 --------ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLK 1573
Query: 283 --------DERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVE 334
+++ +R Q ++ EL + + + E A E +L +T K
Sbjct: 1574 AVQAQGGESQQEAQRLQAQLNELQAQLSQKEQ-----AAEHYKLQMEKAKTHYDAK---- 1624
Query: 335 KNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMK---EKLS---AQASLKRHTSLNDLSL 388
K+ N++ ++ L+S+++++ +EN E++ E+L QA LK T + +
Sbjct: 1625 --KQQNQELQEQLRSLEQLQ-------KENKELRAEAERLGHELQQAGLK--TKEAEQTC 1673
Query: 389 TRDEQEIEFLRLQVLEQQHVIDDL 412
++ L QV + DL
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQLRDL 1697
Score = 49.3 bits (116), Expect = 1e-05
Identities = 93/462 (20%), Positives = 178/462 (38%), Gaps = 77/462 (16%)
Query: 151 LQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECERDIRRLMD 210
LQ +++ +KQ + SN R + E ++ E + I +
Sbjct: 209 LQTPQFQMRRLKKQLADERSN------------RDELELELAENRKLLTEKDAQIAMMQQ 256
Query: 211 EIKGKDRVILALEKELG--VQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGI 268
I DR+ L EK+ ++ + ++L + E+L +L + + + + K ++ I
Sbjct: 257 RI---DRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 269 GDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERN----ELLKRSRE 324
+ E G K+ E S +++L+D L +E + E L++ +
Sbjct: 314 NQLSEENG------------DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361
Query: 325 TEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNL----TRENVEMKEKLSAQASLKRH 380
E +L ++ K + +KNE L + ++EE + L +E E+ + +LK+
Sbjct: 362 LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Query: 381 TSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVET 440
+ + T+ + +E L + +Q+ +LL + H
Sbjct: 422 AATLAANNTQLQARVEMLETERGQQE----------AKLLAERGH--------------- 456
Query: 441 FFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADL--RFCQLTREYQAL 498
F+EE + LS + + + +E+L+ A+ A L + LT E L
Sbjct: 457 ---FEEE---KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 499 QRAYALLQEQVGGTLDAERE-----ARTREQLQADLLRCQAKIEDLEKLLVEKGQDSKWV 553
+++ G +E A+T +Q + + ++E L L +K Q K V
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 554 EEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLE 595
EKQ T QD +++ E E A Q E LE
Sbjct: 571 AEKQ--EATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 82.4 bits (202), Expect = 1e-15
Identities = 131/636 (20%), Positives = 261/636 (41%), Gaps = 104/636 (16%)
Query: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ 60
++++ RS E+ + + + E LR ++ + QQ+K+ ++ +R Q+ ++E Q
Sbjct: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRR----VEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
Query: 61 EQRRHTAYISELK------AKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQ 114
+ T K AK ++K KE++ L++ + E + + + LQR+Q
Sbjct: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQ--LIDKETNDRKCLEDENARLQRVQ 1511
Query: 115 ATLNVLRDGAAD-----KVKTALLTEAR------EEARRAFDGERLRLQQEILELKAARK 163
L A + KV+ LT R + R D + R Q + EL+ ++
Sbjct: 1512 YDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ 1571
Query: 164 QAEEALSNCMQA---DKTKAADLRAAYQAHQ-----------------DEVHRIKRECER 203
+ EE L+ + D K L + + ++ +K+ E
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
Query: 204 DIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRE 263
D+R+ D + G R ++EL ++L + EAL QL+Q +E+ +
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEEL-------RRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
Query: 264 LPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNEL----- 318
I D R + +++I L S+ L + +L +E L
Sbjct: 1685 FQKAIEDK------------SRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
Query: 319 -LKRSRE--------TEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKE 369
L+R R T ++L+ ++ + + + L+ +QR E + R+ +E +
Sbjct: 1733 DLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL----RQEIEKFQ 1788
Query: 370 KLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKS 429
K + +AS + S N + E+E ++++VLEQ D L+R L + +R KS
Sbjct: 1789 KQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQ----DKARLQR---LEDELNRAKS 1841
Query: 430 LKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFC 489
+ V + +++ + ++ L++ R + E + RE+++
Sbjct: 1842 TLEAETRVKQR-LECEKQQIQND-LNQWKTQYSRKEEAIRKIESE------REKSEREKN 1893
Query: 490 QLTREYQALQRAYALLQEQVGGTL-DAEREARTREQLQADLLRCQAKIEDLEKLLV---- 544
L E + LQ ++E+ L D+ RE T+ QL+ + R Q +I+ L +
Sbjct: 1894 SLRSEIERLQAEIKRIEERCRRKLEDSTRE--TQSQLETERSRYQREIDKLRQRPYGSHR 1951
Query: 545 EKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQL 580
E + +W + L+ L +K+ +++ E QL
Sbjct: 1952 ETQTECEWTVDTSKLV--FDGLRKKVTAMQLYECQL 1985
Score = 76.6 bits (187), Expect = 6e-14
Identities = 123/606 (20%), Positives = 255/606 (42%), Gaps = 71/606 (11%)
Query: 23 NEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQ------EQRRHTAYISELKAKL 76
++ LR +L + E + K ++ +L + + +A +R + +Q+ + I + K L
Sbjct: 1232 SKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHL 1291
Query: 77 HEEKTKELQALREGLIRQHE--QEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLT 134
E + +Q E R + +EAA+T + K E++RL+A
Sbjct: 1292 EIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA------------------- 1332
Query: 135 EAREEARRAFDGE------RLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
E +EEA+R ++ E R +EI+ LK + + + + + Y+
Sbjct: 1333 EFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYR 1392
Query: 189 AHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLV 248
A D + R R +I+RL + + + +E+++ Q ++ +K+ L+ +L
Sbjct: 1393 AQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR 1452
Query: 249 QVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRN 308
QV + S ++ + D + +QD++ +++ R + I + + + LED N
Sbjct: 1453 QVTQMRTEESVRYKQ---SLDDAAKT--IQDKN---KEIERLKQLIDKETNDRKCLEDEN 1504
Query: 309 TLLADERNELLK-RSRETEVQLKPLVEKN---------KRMNKKNEDLLQSIQRMEEKIK 358
L + +L K S TE K V++ +R++++ Q I R + +K
Sbjct: 1505 ARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK 1564
Query: 359 NLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERER 418
L + +++E+L+ LKR S + + E+E+E +R + EQ I +L+ + E+
Sbjct: 1565 ELQLQKQKVEEELN---RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQ 1621
Query: 419 LLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDA 478
K+ L+ ++ V++ E+ E L S + R +E + A
Sbjct: 1622 ASIVKKRSEDDLR-QQRDVLDGH--LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA 1678
Query: 479 TAREE-----ADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQ 533
R E + + L ++R +L + L E E R DL R +
Sbjct: 1679 HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGR 1738
Query: 534 AKIE-DLEKLLVEKGQDSKWVEEKQL--------LIRTNQDLLEKIYRLEMEENQLKNEM 584
++ + D ++E + + L L R ++L ++I + + + + N +
Sbjct: 1739 SEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI 1798
Query: 585 QDAKDQ 590
Q++K+Q
Sbjct: 1799 QESKNQ 1804
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/259 (22%), Positives = 115/259 (44%), Gaps = 16/259 (6%)
Query: 328 QLKPLVEKNKRMNKKNEDLLQS-IQRMEEKIKNLTRE-NVEMKEKLSAQASLKRHTSLND 385
+LK E + + K+N D I+ + EKI LT E E + + S + + + D
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
Query: 386 LSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFD 445
+ E E L Q LE + I + E ERL + G + + + + ++
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Query: 446 EESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALL 505
EE + ET N +T + +++ D R + D +L+RE + L+ L
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRL 1256
Query: 506 QEQVGGTLD----AEREARTREQLQADLLRCQAKIE-DLEKLLVEKGQDSKWVEEKQLL- 559
+ + + AE A ++ +++++ + +E +L++++ ++ +D+ KQ L
Sbjct: 1257 NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDN--ARHKQSLE 1314
Query: 560 --IRTNQDLLEKIYRLEME 576
+T QD ++I RL+ E
Sbjct: 1315 EAAKTIQDKNKEIERLKAE 1333
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 80.5 bits (197), Expect = 4e-15
Identities = 144/666 (21%), Positives = 277/666 (41%), Gaps = 117/666 (17%)
Query: 11 KPEMETDAVQMANEELRAKLTSIQ------IEFQQEKSKVGKLRERLQEAKLEREQEQRR 64
K EME ++ EELR + S++ ++ ++E ++ K E L E ++ +E++ +
Sbjct: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-ENEIVQEKQSLQ 522
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD-- 122
+ +S+ K + K ++ LRE RQ KI E E + L T++ LR
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQ--------IKILEQENEHLNQTVSSLRQRS 574
Query: 123 --GAADKVK-----TALLTEAREEARRAF---DGERLRLQQEILELKAARKQAEEALSNC 172
A +VK +L E+ +E + E+ ++++E+ K ++AEE +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 173 MQADKT------KAADLRAA---YQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
+K K +L+ +A + E ++RE R +++ +D K + +LE
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLE 693
Query: 224 KELGVQAGQTQKLLLQKEAL---DEQLVQVKEAERHHSSPKRELPPGIGDM------VEL 274
KE + +L E+L ++ Q++ + S K +L G+ + E
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 275 MGVQDQHMD------ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------- 319
+ V Q +D ++ + KI +L S ++ LE N L EL
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 320 -KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ----RMEE---KIKNLTRENVEMKEKL 371
K ++ E + L + K++ K+N+ L Q + +EE KI NL +EN + L
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN----KTL 869
Query: 372 SAQASLKRHTSLNDLSLTRDEQE------IEFLRLQVLEQQHVIDDLSLER-ERLLRSKR 424
S + + + + + L ++ +E I+ L L + V + L ++ L
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 425 HRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDATAREEA 484
H + + K+ ++ DE+S D S ++ EE + AR E
Sbjct: 930 HELEKIGLNKERLLH-----DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 485 DLRF-CQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKLL 543
+ QL +E + +++ Y L+++ D ER ++ +
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQR----QDEERMVQSSPPI------------------ 1022
Query: 544 VEKGQDSKWVEEKQLLIR---TNQDLLEKIYR----LEMEENQLKNEMQDAKDQNELLEF 596
G+D+KW E Q R +D L ++ R L+ E+ LK +++ + QN L+
Sbjct: 1023 --SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080
Query: 597 RVLELE 602
++L L+
Sbjct: 1081 QILALQ 1086
Score = 77.4 bits (189), Expect = 4e-14
Identities = 123/650 (18%), Positives = 274/650 (42%), Gaps = 118/650 (18%)
Query: 33 IQIEFQQEKSKVGKLRERLQE--------------AKLEREQEQRRHTAYISELK-AKLH 77
+ +E K+K+ +LR+ L+E ++E ++ Q+ + +S+ + A+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 78 EEKTKELQALREGLIRQHEQEAARTAKIKE--GELQRLQATLNVLRDGAADKVKTALLTE 135
+ EL ALRE +R + E + ++ KE +++ +A + L++ ++T + E
Sbjct: 309 RD---ELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 136 AREEARRAFDGERLRLQQEILELKAA-----------RKQAEEALSNCMQADKTKAADL- 183
+ E RA + L++E L+LKA RK+ EE + M + + +
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 184 -------------------RAAYQAHQDEVHR------IKRECE--------RDIRRLMD 210
A ++ EV+ +K E E ++R +D
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 211 EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGD 270
++G IL +EKE Q+L + E L+ ++VQ K++ ++ + ++L
Sbjct: 485 SVEGNASKILKMEKE-------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 271 MVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+ + + ++ ER ++ + + LN + L R+ + A E ++K
Sbjct: 538 LEKTIETLREN-SERQIKILEQENEHLNQTVSSLRQRSQISA-------------EARVK 583
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
+ ++NK +++ ++ + ++E + + + +E KEK L+ N+L
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE-----NELHHLE 638
Query: 391 DEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD 450
E E+ Q I +L + E+ + + L+ + + +T F +
Sbjct: 639 KENEL---------LQKKITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAR-EEADLRFCQLTREYQALQRAYALLQEQV 509
E+L + + D + E L A+ + + L +L E + L++ LL+
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 510 -----------GGTLDAEREARTREQLQADLLRCQAKIEDL--EKLLVEKGQDSKWVEEK 556
G ++ +R +T E + + +++++DL E ++K + + K
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 557 QL--LIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
+L L + N+ L ++ +LE ++ QL+ E + + Q E+ + + E V+
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Score = 75.5 bits (184), Expect = 1e-13
Identities = 146/723 (20%), Positives = 289/723 (39%), Gaps = 130/723 (17%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
K+ + E+ E E ++ NE L+ K+T+++I + K+ L + + ++LERE +
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQ--ENSELERENRK 674
Query: 63 RRHTA-YISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQ----RLQATL 117
+ T L +L + + Q E L + E+ + A +K +LQ L++
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 118 NVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADK 177
L+ G + TE E + + D E RLQ+ + +Q E L + ++
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 178 TKAADLRA----------------AYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILA 221
T +L + + ++ + K++ E++ +RL + + KD +
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 222 LEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQH 281
++G + + L + E V++KE E+ + + I +V L
Sbjct: 855 NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL------- 907
Query: 282 MDERDVRRFQLKIAELNSVIRKL---------------------EDRNTLLADERNELLK 320
D+ +LK ++N+ + KL +DR LL + LK
Sbjct: 908 --REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK 965
Query: 321 RSRET--------EVQLKPLVEKNKRMN------KKNEDLLQSIQRMEEKIKNLT----- 361
+S E E +L+ N+++ KKN + L+ Q E +++
Sbjct: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 362 -----RENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQH---VIDDLS 413
RE+ E +L N+ +L ++Q ++ +L+ LE Q+ L+
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-TQLKQLETQNNNLQAQILA 1084
Query: 414 LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
L+R+ + +++ + K V + +++S++ S + N + + E
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKLQV-------ENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
Query: 474 DLDDATAREEADLRFCQLTREYQALQRAYALLQEQVG----------GTLDA-----ERE 518
+ RE+ + L ++++ L+ LL E+ GTL + E E
Sbjct: 1138 NESVIKEREDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 519 ARTREQLQADLLRCQAKIEDLEK---------LLVEKGQDSKWVEEKQL------LIRTN 563
R E LL+ + ++EDLEK LL K ++ E K+L L T
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
Query: 564 QDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR----DSICCKLSNGADILF 619
LL++ L+ + LK+ + ++K + LE +L+ + D KL+N ++L
Sbjct: 1254 SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1313
Query: 620 EPK 622
+ K
Sbjct: 1314 QLK 1316
Score = 51.2 bits (121), Expect = 3e-06
Identities = 113/550 (20%), Positives = 223/550 (40%), Gaps = 79/550 (14%)
Query: 77 HEEKTKELQALREGL-IRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTE 135
H E EL R+GL H +A++ G ++R ++ ++ + A K K L +
Sbjct: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGSPG-MKRTESRQHLSVELADAKAKIRRLRQ 265
Query: 136 AREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVH 195
EE + L+Q +ELK +++ LS+ A + D A + V
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR--DELDALREKAVRVD 323
Query: 196 RIKRECERDIRRLMD---------EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQ 246
+++ E R RL D E+K ++V+L + L Q T+ + L+++
Sbjct: 324 KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 247 LVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIR 302
+Q+K + E ++++ + + + L Q Q MDE ++L+ S +
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELS 443
Query: 303 KLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME---EKIKN 359
+ ++ L E NEL T +L L +N+ + K E+L ++ +E KI
Sbjct: 444 EAPQKS--LGHEVNEL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
+ +EN + +K +E L ++++++ + + + L
Sbjct: 496 MEKENQRLSKK------------------------VEILENEIVQEKQSLQNCQNLSKDL 531
Query: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
++ K K+++ +++ ++E+ E L++T + + +
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQEN---EHLNQTVSSLRQRSQI------------ 576
Query: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
A+ R + +E + L + ++E E E R Q++ +L + K E
Sbjct: 577 ---SAEARVKDIEKENKILHES---IKETSSKLSKIEFEKR---QIKKELEHYKEKGERA 627
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAK---DQNELLEF 596
E+L E K E Q I + EKI LE E ++L+ E + K D + L F
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 597 RVLELEVRDS 606
++ LE +S
Sbjct: 688 QLESLEKENS 697
Score = 46.6 bits (109), Expect = 7e-05
Identities = 100/469 (21%), Positives = 195/469 (41%), Gaps = 71/469 (15%)
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRL-MDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
D +AA AH EV +E D++ + + ++ +D +E L A ++L+ ++
Sbjct: 151 DTKAAVAAHIQEVTH-NQENVFDLQWMEVTDMSQED-----IEPLLKNMALHLKRLIDER 204
Query: 241 EALDEQLVQVKEAERH------HSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKI 294
+ E ++++ E ER H+S + P G M Q ++ D +
Sbjct: 205 DEHSETIIELSE-ERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAK------ 257
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKN------KRMNKKNEDLLQ 348
A++ + ++LE++ L D + EL + E++LK L ++N R + D L
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNLLSDARSARMYRDELD 313
Query: 349 SIQRMEEKIKNLTRENVEMKEKL-------SAQASLKRHTSLNDLSLTRDEQEIEFLRLQ 401
+++ ++ L E KE+L + LK + + T E ++E R +
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 402 VLEQQHVIDDLSLERERL-LRSKRHRGKSLKPPKKHVVETFF--GFDEESVDSETLSETS 458
++ H LE+E L L++K H + + + +E E +++ E+
Sbjct: 374 -SDKLH-----ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 459 Y------NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGT 512
+ RT P++ L E R +L E Q+L + E++ T
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMENQSLTKTV----EELRTT 482
Query: 513 LDA-EREARTREQLQADLLRCQAKIEDLEKLLVEKGQ--------DSKWVEEKQLLIRTN 563
+D+ E A +++ + R K+E LE +V++ Q ++EK L +T
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 564 QDLLEKIYR----LEMEENQLKNEMQDAKDQNEL-LEFRVLELEVRDSI 607
+ L E R LE E L + + ++++ E RV ++E + I
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Score = 40.4 bits (93), Expect = 0.005
Identities = 96/457 (21%), Positives = 186/457 (40%), Gaps = 83/457 (18%)
Query: 26 LRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHEEKTKELQ 85
LR L S +++ QQ + + KL L++ L +E+ H ++ + KL E K +
Sbjct: 907 LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER--LLHDEQSTDDRYKLLESKLES-- 962
Query: 86 ALREGLIRQHEQEAARTAKIKEGEL--QRLQATLNVLRDGAADKVKTALLTEAREEARRA 143
L++ L + E+ AA A+++E Q+L+ L ++ + +K E ++
Sbjct: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPP 1021
Query: 144 FDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVHRIKRECER 203
GE + ++E E + ++ L ++ ++ A L+A QA + ++ ++ E
Sbjct: 1022 ISGEDNKWERESQETTRELLKVKDRL---IEVERNNAT-LQAEKQALKTQL----KQLET 1073
Query: 204 DIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERH----HSS 259
L +I R ++L+++ Q KL ++ L+ Q + SS
Sbjct: 1074 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1133
Query: 260 PKRELPPGIGDMVELMGVQD---------QHMDERDVRRFQLKIAE---LNSVIRKLEDR 307
+ E I + +L + D + + ER ++ I++ L S + LE
Sbjct: 1134 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 308 NTLLADERNELLKRSRETE------------------------VQLKPLVEKNKRMNKKN 343
+ L D N+LLK+ + E + K L +N R+N
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
Query: 344 EDLLQSIQRMEEKIKNLTR--ENVEMKE-KLSAQAS-LKRHTSLNDLSLTR--------- 390
LL+ + ++ KNL N ++++ +L A+ S LK D++ T+
Sbjct: 1254 SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1313
Query: 391 ------DEQ------EIEFLRLQ---VLEQQHVIDDL 412
+E+ +I+ L LQ +LEQ DL
Sbjct: 1314 QLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350
Score = 31.6 bits (70), Expect = 2.3
Identities = 33/184 (17%), Positives = 85/184 (46%), Gaps = 8/184 (4%)
Query: 15 ETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
ET+ +Q ++ L++ L + ++E + +++ KL+E+ Q+ + + +S+LK
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-TSTKLNNQCELLSQLKG 1317
Query: 75 KLHEEKTKELQALREGLIRQHE--QEAARTAKIKEGELQRLQATLNVLRDGAADKVKTAL 132
L EE L ++ +++ ++ + + E ++ LN LR +K++ +
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR-RQKEKLEEKI 1376
Query: 133 LTEAR----EEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
+ + + RR + L++++ I K ++ +++L+ + L+ +Q
Sbjct: 1377 MDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1436
Query: 189 AHQD 192
QD
Sbjct: 1437 DSQD 1440
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 80.1 bits (196), Expect = 6e-15
Identities = 144/667 (21%), Positives = 278/667 (41%), Gaps = 118/667 (17%)
Query: 11 KPEMETDAVQMANEELRAKLTSIQ------IEFQQEKSKVGKLRERLQEAKLEREQEQRR 64
K EME ++ EELR + S++ ++ ++E ++ K E L E ++ +E++ +
Sbjct: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-ENEIVQEKQSLQ 522
Query: 65 HTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRD-- 122
+ +S+ K + K ++ LRE RQ KI E E + L T++ LR
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQ--------IKILEQENEHLNQTVSSLRQRS 574
Query: 123 --GAADKVK-----TALLTEAREEARRAF---DGERLRLQQEILELKAARKQAEEALSNC 172
A +VK +L E+ +E + E+ ++++E+ K ++AEE +
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 173 MQADKT------KAADLRAA---YQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALE 223
+K K +L+ +A + E ++RE R +++ +D K + +LE
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERE-NRKLKKTLDSFKNLTFQLESLE 693
Query: 224 KELGVQAGQTQKLLLQKEAL---DEQLVQVKEAERHHSSPKRELPPGIGDM------VEL 274
KE + +L E+L ++ Q++ + S K +L G+ + E
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 275 MGVQDQHMD------ERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELL--------- 319
+ V Q +D ++ + KI +L S ++ LE N L EL
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 320 -KRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ----RMEE---KIKNLTRENVEMKEKL 371
K ++ E + L + K++ K+N+ L Q + +EE KI NL +EN + L
Sbjct: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN----KTL 869
Query: 372 SAQASLKRHTSLNDLSLTRDEQE------IEFLRLQVLEQQHVIDDLSLER-ERLLRSKR 424
S + + + + + L ++ +E I+ L L + V + L ++ L
Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
Query: 425 HRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRT-DRTPATPEEDLDDATAREE 483
H + + K+ ++ DE+S D + T ++ EE + AR E
Sbjct: 930 HELEKIGLNKERLLH-----DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
Query: 484 ADLRF-CQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDLEKL 542
+ QL +E + +++ Y L+++ D ER ++ +
Sbjct: 985 ESTNYNQQLRQELKTVKKNYEALKQR----QDEERMVQSSPPI----------------- 1023
Query: 543 LVEKGQDSKWVEEKQLLIR---TNQDLLEKIYR----LEMEENQLKNEMQDAKDQNELLE 595
G+D+KW E Q R +D L ++ R L+ E+ LK +++ + QN L+
Sbjct: 1024 ---SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 596 FRVLELE 602
++L L+
Sbjct: 1081 AQILALQ 1087
Score = 77.4 bits (189), Expect = 4e-14
Identities = 123/650 (18%), Positives = 274/650 (42%), Gaps = 118/650 (18%)
Query: 33 IQIEFQQEKSKVGKLRERLQE--------------AKLEREQEQRRHTAYISELK-AKLH 77
+ +E K+K+ +LR+ L+E ++E ++ Q+ + +S+ + A+++
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 78 EEKTKELQALREGLIRQHEQEAARTAKIKE--GELQRLQATLNVLRDGAADKVKTALLTE 135
+ EL ALRE +R + E + ++ KE +++ +A + L++ ++T + E
Sbjct: 309 RD---ELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 136 AREEARRAFDGERLRLQQEILELKAA-----------RKQAEEALSNCMQADKTKAADL- 183
+ E RA + L++E L+LKA RK+ EE + M + + +
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 184 -------------------RAAYQAHQDEVHR------IKRECE--------RDIRRLMD 210
A ++ EV+ +K E E ++R +D
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 211 EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGD 270
++G IL +EKE Q+L + E L+ ++VQ K++ ++ + ++L
Sbjct: 485 SVEGNASKILKMEKE-------NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
Query: 271 MVELMGVQDQHMDERDVRRFQLKIAELNSVIRKLEDRNTLLADERNELLKRSRETEVQLK 330
+ + + ++ ER ++ + + LN + L R+ + A E ++K
Sbjct: 538 LEKTIETLREN-SERQIKILEQENEHLNQTVSSLRQRSQISA-------------EARVK 583
Query: 331 PLVEKNKRMNKKNEDLLQSIQRMEEKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTR 390
+ ++NK +++ ++ + ++E + + + +E KEK L+ N+L
Sbjct: 584 DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE-----NELHHLE 638
Query: 391 DEQEIEFLRLQVLEQQHVIDDLSLERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVD 450
E E+ Q I +L + E+ + + L+ + + +T F +
Sbjct: 639 KENEL---------LQKKITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKNLTFQ 688
Query: 451 SETLSETSYNTDRTDRTPATPEEDLDDATAR-EEADLRFCQLTREYQALQRAYALLQEQV 509
E+L + + D + E L A+ + + L +L E + L++ LL+
Sbjct: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 510 -----------GGTLDAEREARTREQLQADLLRCQAKIEDL--EKLLVEKGQDSKWVEEK 556
G ++ +R +T E + + +++++DL E ++K + + K
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 557 QL--LIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR 604
+L L + N+ L ++ +LE ++ QL+ E + + Q E+ + + E V+
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Score = 74.7 bits (182), Expect = 2e-13
Identities = 145/723 (20%), Positives = 297/723 (41%), Gaps = 129/723 (17%)
Query: 3 KKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQ 62
K+ + E+ E E ++ NE L+ K+T+++I + K+ L + + ++LERE +
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQ--ENSELERENRK 674
Query: 63 RRHTA-YISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQ----RLQATL 117
+ T L +L + + Q E L + E+ + A +K +LQ L++
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 118 NVLRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADK 177
L+ G + TE E + + D E RLQ+ + +Q E L + ++
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 178 TKAADLRA----------------AYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILA 221
T +L + + ++ + K++ E++ +RL + + KD +
Sbjct: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 222 LEKELGVQAGQTQKLLLQKEALDEQLVQVKEAERHHSSPKRELPPGIGDMVEL------- 274
++G + + L + E V++KE E+ + + I +V L
Sbjct: 855 NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914
Query: 275 --------------------MGVQDQHM--DER--DVRRFQLKIAELNSVIRKL----ED 306
+G+ + + DE+ D R++L ++L S ++K E+
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 307 RNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQ----------RMEEK 356
+ L E +++ +LK V+KN K+ +D + +Q + E +
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKT-VKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 357 IKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQH---VIDDLS 413
+ TRE +++K++L N+ +L ++Q ++ +L+ LE Q+ L+
Sbjct: 1034 SQETTRELLKVKDRLI-------EVERNNATLQAEKQALK-TQLKQLETQNNNLQAQILA 1085
Query: 414 LERERLLRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEE 473
L+R+ + +++ + K V + +++S++ S + N + + E
Sbjct: 1086 LQRQTVSLQEQNTTLQTQNAKLQV-------ENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
Query: 474 DLDDATAREEADLRFCQLTREYQALQRAYALLQEQVG----------GTLDA-----ERE 518
+ RE+ + L ++++ L+ LL E+ GTL + E E
Sbjct: 1139 NESVIKEREDLKSLYDSLIKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNLEVE 1194
Query: 519 ARTREQLQADLLRCQAKIEDLEK---------LLVEKGQDSKWVEEKQL------LIRTN 563
R E LL+ + ++EDLEK LL K ++ E K+L L T
Sbjct: 1195 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1254
Query: 564 QDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVLELEVR----DSICCKLSNGADILF 619
LL++ L+ + LK+ + ++K + LE +L+ + D KL+N ++L
Sbjct: 1255 SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1314
Query: 620 EPK 622
+ K
Sbjct: 1315 QLK 1317
Score = 51.2 bits (121), Expect = 3e-06
Identities = 113/550 (20%), Positives = 223/550 (40%), Gaps = 79/550 (14%)
Query: 77 HEEKTKELQALREGL-IRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTE 135
H E EL R+GL H +A++ G ++R ++ ++ + A K K L +
Sbjct: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGSPG-MKRTESRQHLSVELADAKAKIRRLRQ 265
Query: 136 AREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQAHQDEVH 195
EE + L+Q +ELK +++ LS+ A + D A + V
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYR--DELDALREKAVRVD 323
Query: 196 RIKRECERDIRRLMD---------EIKGKDRVILALEKELGVQAGQTQKLLLQKEALDEQ 246
+++ E R RL D E+K ++V+L + L Q T+ + L+++
Sbjct: 324 KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 247 LVQVK----EAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNSVIR 302
+Q+K + E ++++ + + + L Q Q MDE ++L+ S +
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELS 443
Query: 303 KLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME---EKIKN 359
+ ++ L E NEL T +L L +N+ + K E+L ++ +E KI
Sbjct: 444 EAPQKS--LGHEVNEL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
Query: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
+ +EN + +K +E L ++++++ + + + L
Sbjct: 496 MEKENQRLSKK------------------------VEILENEIVQEKQSLQNCQNLSKDL 531
Query: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
++ K K+++ +++ ++E+ E L++T + + +
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQEN---EHLNQTVSSLRQRSQI------------ 576
Query: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
A+ R + +E + L + ++E E E R Q++ +L + K E
Sbjct: 577 ---SAEARVKDIEKENKILHES---IKETSSKLSKIEFEKR---QIKKELEHYKEKGERA 627
Query: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAK---DQNELLEF 596
E+L E K E Q I + EKI LE E ++L+ E + K D + L F
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 597 RVLELEVRDS 606
++ LE +S
Sbjct: 688 QLESLEKENS 697
Score = 46.6 bits (109), Expect = 7e-05
Identities = 100/469 (21%), Positives = 195/469 (41%), Gaps = 71/469 (15%)
Query: 182 DLRAAYQAHQDEVHRIKRECERDIRRL-MDEIKGKDRVILALEKELGVQAGQTQKLLLQK 240
D +AA AH EV +E D++ + + ++ +D +E L A ++L+ ++
Sbjct: 151 DTKAAVAAHIQEVTH-NQENVFDLQWMEVTDMSQED-----IEPLLKNMALHLKRLIDER 204
Query: 241 EALDEQLVQVKEAERH------HSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKI 294
+ E ++++ E ER H+S + P G M Q ++ D +
Sbjct: 205 DEHSETIIELSE-ERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAK------ 257
Query: 295 AELNSVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKN------KRMNKKNEDLLQ 348
A++ + ++LE++ L D + EL + E++LK L ++N R + D L
Sbjct: 258 AKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNLLSDARSARMYRDELD 313
Query: 349 SIQRMEEKIKNLTRENVEMKEKL-------SAQASLKRHTSLNDLSLTRDEQEIEFLRLQ 401
+++ ++ L E KE+L + LK + + T E ++E R +
Sbjct: 314 ALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRAR 373
Query: 402 VLEQQHVIDDLSLERERL-LRSKRHRGKSLKPPKKHVVETFF--GFDEESVDSETLSETS 458
++ H LE+E L L++K H + + + +E E +++ E+
Sbjct: 374 -SDKLH-----ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 459 Y------NTDRTDRTPATPEEDLDDATAREEADLRFCQLTREYQALQRAYALLQEQVGGT 512
+ RT P++ L E R +L E Q+L + E++ T
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGH-EVNELTSSRLLKLEMENQSLTKTV----EELRTT 482
Query: 513 LDA-EREARTREQLQADLLRCQAKIEDLEKLLVEKGQ--------DSKWVEEKQLLIRTN 563
+D+ E A +++ + R K+E LE +V++ Q ++EK L +T
Sbjct: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 564 QDLLEKIYR----LEMEENQLKNEMQDAKDQNEL-LEFRVLELEVRDSI 607
+ L E R LE E L + + ++++ E RV ++E + I
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/418 (19%), Positives = 165/418 (39%), Gaps = 37/418 (8%)
Query: 20 QMANEELRAKLTSIQIEFQQEKS------KVGKLRERLQEA---KLEREQEQRRHTAYIS 70
+ + ++ R KL ++E +KS K+ L RL+E+ + QE +
Sbjct: 946 EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1005
Query: 71 ELKAKLHEEKTKELQALREGLIRQHEQEAARTA----KIKEG--ELQRLQATLNVLRDGA 124
LK + EE+ + G + E+E+ T K+K+ E++R ATL +
Sbjct: 1006 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1065
Query: 125 ADKVKTALLTEAREEAR-RAFDGERLRLQQE--ILELKAARKQAEEALSNCMQAD-KTKA 180
++K +A+ A + + LQ++ L+ + A+ Q E + N +
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1125
Query: 181 ADLRAAYQAHQDEVHRIKRECERDIRRLMDE-IKGKDRVILALEKELGVQAGQTQKLLLQ 239
A L + ++E + +E E D++ L D IK +++ L E+ QA + + L+ +
Sbjct: 1126 AQLLIQQSSLENENESVIKERE-DLKSLYDSLIKDHEKLELLHER----QASEYESLISK 1180
Query: 240 KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELN- 298
L K A ++ R+L +++ G + V + ++ + N
Sbjct: 1181 HGTL-------KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1233
Query: 299 ----SVIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRME 354
+ +KL N L ++LLK + + K L + L +++
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 355 EKIKNLTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDL 412
E+ + L + ++ + + LK + + L Q + +LEQ DL
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351
Score = 31.6 bits (70), Expect = 2.3
Identities = 33/184 (17%), Positives = 85/184 (46%), Gaps = 8/184 (4%)
Query: 15 ETDAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKA 74
ET+ +Q ++ L++ L + ++E + +++ KL+E+ Q+ + + +S+LK
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI-TSTKLNNQCELLSQLKG 1318
Query: 75 KLHEEKTKELQALREGLIRQHE--QEAARTAKIKEGELQRLQATLNVLRDGAADKVKTAL 132
L EE L ++ +++ ++ + + E ++ LN LR +K++ +
Sbjct: 1319 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR-RQKEKLEEKI 1377
Query: 133 LTEAR----EEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAADLRAAYQ 188
+ + + RR + L++++ I K ++ +++L+ + L+ +Q
Sbjct: 1378 MDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
Query: 189 AHQD 192
QD
Sbjct: 1438 DSQD 1441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,803,061
Number of Sequences: 37866
Number of extensions: 941011
Number of successful extensions: 12492
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 1000
Number of HSP's that attempted gapping in prelim test: 5346
Number of HSP's gapped (non-prelim): 4622
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.