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Search of human proteins with 21361991
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
(471 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 950 0.0
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 428 e-120
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 428 e-120
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 428 e-120
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 407 e-114
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 387 e-107
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 147 2e-35
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 147 2e-35
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 139 4e-33
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 135 8e-32
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 130 3e-30
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 91 3e-18
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 91 3e-18
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 79 7e-15
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 75 1e-13
gi|239735519 SET binding factor 1 [Homo sapiens] 74 2e-13
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 69 7e-12
gi|29788755 SET binding factor 2 [Homo sapiens] 69 7e-12
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 66 6e-11
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 65 1e-10
gi|209863002 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862998 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862994 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|18860873 MAP-kinase activating death domain-containing protei... 51 2e-06
gi|209862987 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862983 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862979 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862975 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209862971 MAP-kinase activating death domain-containing prote... 51 2e-06
gi|209571517 MAP-kinase activating death domain-containing prote... 51 2e-06
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 950 bits (2455), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVV 60
MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVV
Sbjct: 1 MEGQVVGRVFRLFQRRLLQLRAGPPQDNSGEALKEPERAQEHSLPNFAGGQHFFEYLLVV 60
Query: 61 SLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRE 120
SLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRE
Sbjct: 61 SLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRE 120
Query: 121 TFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQIS 180
TFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQIS
Sbjct: 121 TFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQIS 180
Query: 181 MAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLS 240
MAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLS
Sbjct: 181 MAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLS 240
Query: 241 FEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVC 300
FEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVC
Sbjct: 241 FEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVC 300
Query: 301 CPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQ 360
CPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQ
Sbjct: 301 CPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQ 360
Query: 361 GINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR 420
GINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR
Sbjct: 361 GINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRR 420
Query: 421 FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK 471
FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK
Sbjct: 421 FVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQKKPREKTVK 471
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 428 bits (1101), Expect = e-120
Identities = 211/419 (50%), Positives = 294/419 (70%), Gaps = 12/419 (2%)
Query: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
+ FEY +VVSLKKK S + Y P ++YQFPK + + +E EERL KAIP FCFPD +
Sbjct: 694 RELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERL-KAIPQFCFPDAKD 752
Query: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
W ++EY ETFSF+LT DGSR+ GYCRRLLP+G GPRLP+VYC+IS +GCFGLFSK+L
Sbjct: 753 WLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVL 812
Query: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
DEVE+R IS A++YPFM+ L E+ FPAPGKT+ +K+F+P +G E + L RP+DS LEHV
Sbjct: 813 DEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHV 872
Query: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
DF L CLS Q+++IFAS +LER++IF+A+ LSTLS C HA ALLYPFSW HT+IPV
Sbjct: 873 DFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPV 932
Query: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
+P S++ VCCPTPF+VG+ ++ + P+EE L+VNL F+ + DE +LP KL
Sbjct: 933 LPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 992
Query: 351 QDDILDSLGQGINELKTAEQ----------INEHVSGPFVQFFVKIVGHYASYIKREANG 400
Q + +L + NEL + + +N VS F++FFV+ VGHY+ ++ + G
Sbjct: 993 QAALEQAL-ERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKG 1051
Query: 401 QGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQ 459
+ FQ +F K++ SK+ RRF++ F+++Q+F+ FIQ+ E K G F+Q++ +Y E+
Sbjct: 1052 ERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEE 1110
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 428 bits (1101), Expect = e-120
Identities = 211/419 (50%), Positives = 294/419 (70%), Gaps = 12/419 (2%)
Query: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
+ FEY +VVSLKKK S + Y P ++YQFPK + + +E EERL KAIP FCFPD +
Sbjct: 694 RELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERL-KAIPQFCFPDAKD 752
Query: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
W ++EY ETFSF+LT DGSR+ GYCRRLLP+G GPRLP+VYC+IS +GCFGLFSK+L
Sbjct: 753 WLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVL 812
Query: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
DEVE+R IS A++YPFM+ L E+ FPAPGKT+ +K+F+P +G E + L RP+DS LEHV
Sbjct: 813 DEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHV 872
Query: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
DF L CLS Q+++IFAS +LER++IF+A+ LSTLS C HA ALLYPFSW HT+IPV
Sbjct: 873 DFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPV 932
Query: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
+P S++ VCCPTPF+VG+ ++ + P+EE L+VNL F+ + DE +LP KL
Sbjct: 933 LPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 992
Query: 351 QDDILDSLGQGINELKTAEQ----------INEHVSGPFVQFFVKIVGHYASYIKREANG 400
Q + +L + NEL + + +N VS F++FFV+ VGHY+ ++ + G
Sbjct: 993 QAALEQAL-ERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKG 1051
Query: 401 QGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQ 459
+ FQ +F K++ SK+ RRF++ F+++Q+F+ FIQ+ E K G F+Q++ +Y E+
Sbjct: 1052 ERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEE 1110
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 428 bits (1101), Expect = e-120
Identities = 211/419 (50%), Positives = 294/419 (70%), Gaps = 12/419 (2%)
Query: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
+ FEY +VVSLKKK S + Y P ++YQFPK + + +E EERL KAIP FCFPD +
Sbjct: 274 RELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERL-KAIPQFCFPDAKD 332
Query: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
W ++EY ETFSF+LT DGSR+ GYCRRLLP+G GPRLP+VYC+IS +GCFGLFSK+L
Sbjct: 333 WLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVL 392
Query: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
DEVE+R IS A++YPFM+ L E+ FPAPGKT+ +K+F+P +G E + L RP+DS LEHV
Sbjct: 393 DEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHV 452
Query: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
DF L CLS Q+++IFAS +LER++IF+A+ LSTLS C HA ALLYPFSW HT+IPV
Sbjct: 453 DFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPV 512
Query: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
+P S++ VCCPTPF+VG+ ++ + P+EE L+VNL F+ + DE +LP KL
Sbjct: 513 LPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 572
Query: 351 QDDILDSLGQGINELKTAEQ----------INEHVSGPFVQFFVKIVGHYASYIKREANG 400
Q + +L + NEL + + +N VS F++FFV+ VGHY+ ++ + G
Sbjct: 573 QAALEQAL-ERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKG 631
Query: 401 QGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQ 459
+ FQ +F K++ SK+ RRF++ F+++Q+F+ FIQ+ E K G F+Q++ +Y E+
Sbjct: 632 ERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEE 690
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 407 bits (1047), Expect = e-114
Identities = 206/422 (48%), Positives = 283/422 (67%), Gaps = 8/422 (1%)
Query: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
Q FE +VVSL+KK S Y P + QFP +++ Q ++ E LK IP FCFPD +
Sbjct: 431 QQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD 490
Query: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
W +E ETFSFVLT DGSR GYC++LLP G G RLP+VYC++S +GCF LFSKIL
Sbjct: 491 WMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKIL 550
Query: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
DEVEKR ++S A++YPFM+ + EA FPAPG+T+T+KS++P +G E I L RPLDS LEHV
Sbjct: 551 DEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHV 610
Query: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
DF L CLS ++++ AS +LER++IF+A LSTLS+C HA A LYPF+W HTYIPV
Sbjct: 611 DFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPV 670
Query: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
+P S++ VC PTPF++G+ ++ D P+EEVL+V+LC FL V DE +ILPPKL
Sbjct: 671 LPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKL 730
Query: 351 QDDILDSLGQGINELKTAEQ-------INEHVSGPFVQFFVKIVGHYASYIKREANGQGH 403
Q ++ L + NE+ T EQ +N VS FV+FFV++VGHY+ + G+
Sbjct: 731 QAALMQILEER-NEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERV 789
Query: 404 FQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQKKQK 463
FQ F K+ TS++ R F+ F++TQ+F+ FIQ+ E K+ G F+ + ++Y E +
Sbjct: 790 FQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPES 849
Query: 464 KP 465
+P
Sbjct: 850 EP 851
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 387 bits (993), Expect = e-107
Identities = 204/423 (48%), Positives = 277/423 (65%), Gaps = 17/423 (4%)
Query: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFP-KRENLLRGQQEEEERLLKAIPLFCFPDGN 109
+ FEY +VVSL KK++ Y P +T QFP K E + +E E++L KAIP FCFPD
Sbjct: 562 RQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQL-KAIPQFCFPDAK 620
Query: 110 EWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKI 169
+W + ++ ETFSFVLT DGSR+ GYCRRLLP G G RLP+VYCI+S +GCF LFS+I
Sbjct: 621 DWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRI 680
Query: 170 LDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEH 229
LDEVEKR IS A++ P M+ + EA FPA GKT+ +K+F+P SGTE I L RPLDS LEH
Sbjct: 681 LDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEH 740
Query: 230 VDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIP 289
VDF SL LS ++ +FAS +LER++IF+A+ LS LS+C HA AL+YPF+W HTYIP
Sbjct: 741 VDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIP 800
Query: 290 VVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPK 349
V+P +++ VC PTPF++G+ + + P+EEVL+V+L FL + DE ILP K
Sbjct: 801 VLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRK 860
Query: 350 LQDDILDSLGQGINELKTAEQ--------------INEHVSGPFVQFFVKIVGHYASYIK 395
LQ L+ + + NEL + +NE VS FV+FFV+IVGHY+ ++
Sbjct: 861 LQ-VALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLT 919
Query: 396 REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILE 455
+ Q +F KA++SK+ R F++ F++TQ+F FIQE E + G F+ + E
Sbjct: 920 SGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQE 979
Query: 456 YEE 458
Y E
Sbjct: 980 YLE 982
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 147 bits (371), Expect = 2e-35
Identities = 107/393 (27%), Positives = 193/393 (49%), Gaps = 44/393 (11%)
Query: 72 EPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDG 131
+P + QFP + ++ +L+ + FCFP + ++++ + F+FVLT++D
Sbjct: 30 DPEVQRQFP--------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDS 80
Query: 132 SRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL----DEVEKRHQISMAVIYPF 187
++ G+CR L +G +CI+S + F +F K+L D KR + +
Sbjct: 81 KQRFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL--- 131
Query: 188 MQGLREAAFPAPGKTVTLKSF----IPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQ 243
++ L + P PG +V L +PD TR L S E+ + + +
Sbjct: 132 LETLHKLPIPDPGVSVHLSVHSYFTVPD--------TRELPSIPENRNLTEYFVAVDVNN 183
Query: 244 ILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPT 303
+L ++AS + ER+I+ + LSTL+ CIH +AA+LYP W H YIPV+P LL C P
Sbjct: 184 MLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPM 243
Query: 304 PFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGIN 363
P+++G+ + ++V + +++V+++N+ T L + D+ LP +D++ SL +
Sbjct: 244 PYLIGIHLSLMEKVRNMALDDVVILNVDTNT-LETPFDDLQSLP----NDVISSLKNRLK 298
Query: 364 ELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVK 423
++ T + V+ F++ G Y + +K E F E +F S R+F++
Sbjct: 299 KVSTT--TGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQ 356
Query: 424 KFVKTQLFSLFIQEAEKSKNPPAGY---FQQKI 453
+ QLF FI N G+ F+++I
Sbjct: 357 NATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEI 389
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 147 bits (371), Expect = 2e-35
Identities = 107/393 (27%), Positives = 193/393 (49%), Gaps = 44/393 (11%)
Query: 72 EPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEYPRETFSFVLTNVDG 131
+P + QFP + ++ +L+ + FCFP + ++++ + F+FVLT++D
Sbjct: 30 DPEVQRQFP--------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDS 80
Query: 132 SRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL----DEVEKRHQISMAVIYPF 187
++ G+CR L +G +CI+S + F +F K+L D KR + +
Sbjct: 81 KQRFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL--- 131
Query: 188 MQGLREAAFPAPGKTVTLKSF----IPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQ 243
++ L + P PG +V L +PD TR L S E+ + + +
Sbjct: 132 LETLHKLPIPDPGVSVHLSVHSYFTVPD--------TRELPSIPENRNLTEYFVAVDVNN 183
Query: 244 ILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPT 303
+L ++AS + ER+I+ + LSTL+ CIH +AA+LYP W H YIPV+P LL C P
Sbjct: 184 MLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPM 243
Query: 304 PFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGIN 363
P+++G+ + ++V + +++V+++N+ T L + D+ LP +D++ SL +
Sbjct: 244 PYLIGIHLSLMEKVRNMALDDVVILNVDTNT-LETPFDDLQSLP----NDVISSLKNRLK 298
Query: 364 ELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVK 423
++ T + V+ F++ G Y + +K E F E +F S R+F++
Sbjct: 299 KVSTT--TGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQ 356
Query: 424 KFVKTQLFSLFIQEAEKSKNPPAGY---FQQKI 453
+ QLF FI N G+ F+++I
Sbjct: 357 NATQLQLFKQFIDGRLDLLNSGEGFSDVFEEEI 389
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 139 bits (351), Expect = 4e-33
Identities = 112/408 (27%), Positives = 205/408 (50%), Gaps = 48/408 (11%)
Query: 58 LVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEY 117
LV+ +K SE++ +P++ ++FP+ G QE +L+++P FCFP E S +
Sbjct: 15 LVLKVKCHASENE-DPVVLWKFPEDF----GDQE----ILQSVPKFCFPFDVERVSQNQV 65
Query: 118 PRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEV---- 173
+ F+FVLT+++ ++ G+CR L +G L CI+S + F ++ K+L+ +
Sbjct: 66 GQH-FTFVLTDIESKQRFGFCR--LTSGGTICL----CILSYLPWFEVYYKLLNTLADYL 118
Query: 174 --EKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFI--PD-SGTEFISLTRPLDSHLE 228
E + ++ + + + +A P +++ S+ PD +G I +R L +
Sbjct: 119 AKELENDLNETLRSLYNHPVPKANTPV---NLSVHSYFIAPDVTGLPTIPESRNLTEYFV 175
Query: 229 HVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYI 288
VD +++L Q++AS + ER+I+ ++ LSTL+ CIH +AALLYP W H YI
Sbjct: 176 AVDVNNML---------QLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYI 226
Query: 289 PVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPP 348
PV+P LL C P P+++G+ + V + +E+V+++N+ T D +
Sbjct: 227 PVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN---- 282
Query: 349 KLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYASYIKREANGQGHFQERS 408
L D++ +L + + TA + V+ F++ + G Y ++ + F E S
Sbjct: 283 -LPSDVVSALKNKLKKQSTA--TGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEES 339
Query: 409 FCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGY---FQQKI 453
F K S ++F++ + QLF FI N G+ F+++I
Sbjct: 340 FVKH-RSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEI 386
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 135 bits (340), Expect = 8e-32
Identities = 115/425 (27%), Positives = 202/425 (47%), Gaps = 62/425 (14%)
Query: 58 LVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLTEY 117
LV+ +K SE++ +P++ ++FP+ G QE +L+++P FCFP E S +
Sbjct: 15 LVLKVKCHASENE-DPVVLWKFPEDF----GDQE----ILQSVPKFCFPFDVERVSQNQV 65
Query: 118 PRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILD------ 171
+ F+FVLT+++ ++ G+CR L +G L CI+S + F ++ K+L+
Sbjct: 66 GQH-FTFVLTDIESKQRFGFCR--LTSGGTICL----CILSYLPWFEVYYKLLNTLADYL 118
Query: 172 --EVEKRHQISMAVIY---------PFMQGLREAAFPA--------PGKTVTLKSFIPD- 211
E+E ++ +Y P + + F A P PD
Sbjct: 119 AKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDV 178
Query: 212 SGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCI 271
+G I +R L + VD +++L Q++AS + ER+I+ ++ LSTL+ CI
Sbjct: 179 TGLPTIPESRNLTEYFVAVDVNNML---------QLYASMLHERRIVIISSKLSTLTACI 229
Query: 272 HAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLC 331
H +AALLYP W H YIPV+P LL C P P+++G+ + V + +E+V+++N+
Sbjct: 230 HGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVD 289
Query: 332 EGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQFFVKIVGHYA 391
T D + L D++ +L + + TA + V+ F++ + G Y
Sbjct: 290 TNTLESPFSDLNN-----LPSDVVSALKNKLKKQSTA--TGDGVARAFLRAQAALFGSYR 342
Query: 392 SYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGY--- 448
++ + F E SF K S ++F++ + QLF FI N G+
Sbjct: 343 DALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDV 401
Query: 449 FQQKI 453
F+++I
Sbjct: 402 FEEEI 406
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 130 bits (326), Expect = 3e-30
Identities = 117/434 (26%), Positives = 194/434 (44%), Gaps = 73/434 (16%)
Query: 53 FFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWA 112
FFE SL++ +P I QFP ++ ++ +P FCFP E
Sbjct: 16 FFEAACPASLQE-------DPPILRQFPP--------DFRDQEAMQMVPKFCFPFDVE-- 58
Query: 113 SLTEYPR---ETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKI 169
E P + F+F LT++ G+R+ G+CR L AG L CI+S + F +F K+
Sbjct: 59 --REPPSPAVQHFTFALTDLAGNRRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKL 110
Query: 170 L---------DEVEKRHQISMAVIYPFMQGLREAAF-----------------PAPGKTV 203
L D+V + ++ + + G + + P G +
Sbjct: 111 LNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSK 170
Query: 204 TLKSFI-PDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAE 262
L F+ PDSG L S E+ + + L+ ++ E I+ +FA+ + ER+++ A
Sbjct: 171 PLSCFVAPDSGR--------LPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTAS 222
Query: 263 GLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPM 322
LSTL+ C+HA+ ALLYP W H IP +P LL C P P+++GV + V + +
Sbjct: 223 KLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKAL 282
Query: 323 EEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGINELKTAEQINEHVSGPFVQF 382
E+V+++N+ T L + ++ LPP D++ L + ++ A E VS F++
Sbjct: 283 EDVVVLNVDANT-LETTFNDVQALPP----DVVSLLRLRLRKVALAP--GEGVSRLFLKA 335
Query: 383 FVKIVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSK 442
+ G Y + F E F + F ++ V QLF FI+ +
Sbjct: 336 QALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKL 395
Query: 443 NPPAGY---FQQKI 453
N G+ F+Q+I
Sbjct: 396 NKGEGFSDQFEQEI 409
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 90.5 bits (223), Expect = 3e-18
Identities = 103/427 (24%), Positives = 175/427 (40%), Gaps = 82/427 (19%)
Query: 85 LLRGQQEEEER--LLKAIPLFCFPDGNE---WASLTEYPRETFS-FVLTNVDGSRKIGYC 138
+ R QE+ E L +++PLFC P G W S ++YP FS FVLT + G
Sbjct: 213 ICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAA 272
Query: 139 ---------------RRLL----------PAGPGPRLPKVYCIISCIGCFGLFSKILDEV 173
+RLL + K C++S F F K L +
Sbjct: 273 IQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFL 332
Query: 174 EKRHQISMAVIYPFMQGL----REAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL-- 227
R+ IS + P + + + FP+P + L P + L++P+ S L
Sbjct: 333 Y-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPL 388
Query: 228 EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTY 287
FS+LL L E + + AV E KI+ + S L+ A ++++PF W Y
Sbjct: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
Query: 288 IPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKD--- 344
+P+ P +L + P PF+VG+ R+ + P +V V++ T + +GD+K+
Sbjct: 449 VPLCPLALADVLSAPCPFIVGIDSRYFD--LYDPPPDVSCVDVDTNT-ISQIGDKKNVAW 505
Query: 345 -ILPPKLQDDILDSLGQ-------------------------GINELKTAEQINEHVSGP 378
ILP K +++++L N K I+ +
Sbjct: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
Query: 379 FVQFFVKIVGHYASYIK--------REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQL 430
F+ F I+ Y SY++ + F ++F ++ +++++F KTQ+
Sbjct: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQM 624
Query: 431 FSLFIQE 437
F FI+E
Sbjct: 625 FIRFIEE 631
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 90.5 bits (223), Expect = 3e-18
Identities = 103/427 (24%), Positives = 175/427 (40%), Gaps = 82/427 (19%)
Query: 85 LLRGQQEEEER--LLKAIPLFCFPDGNE---WASLTEYPRETFS-FVLTNVDGSRKIGYC 138
+ R QE+ E L +++PLFC P G W S ++YP FS FVLT + G
Sbjct: 213 ICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAA 272
Query: 139 ---------------RRLL----------PAGPGPRLPKVYCIISCIGCFGLFSKILDEV 173
+RLL + K C++S F F K L +
Sbjct: 273 IQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFL 332
Query: 174 EKRHQISMAVIYPFMQGL----REAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL-- 227
R+ IS + P + + + FP+P + L P + L++P+ S L
Sbjct: 333 Y-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPL 388
Query: 228 EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTY 287
FS+LL L E + + AV E KI+ + S L+ A ++++PF W Y
Sbjct: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
Query: 288 IPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKD--- 344
+P+ P +L + P PF+VG+ R+ + P +V V++ T + +GD+K+
Sbjct: 449 VPLCPLALADVLSAPCPFIVGIDSRYFD--LYDPPPDVSCVDVDTNT-ISQIGDKKNVAW 505
Query: 345 -ILPPKLQDDILDSLGQ-------------------------GINELKTAEQINEHVSGP 378
ILP K +++++L N K I+ +
Sbjct: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
Query: 379 FVQFFVKIVGHYASYIK--------REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQL 430
F+ F I+ Y SY++ + F ++F ++ +++++F KTQ+
Sbjct: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQM 624
Query: 431 FSLFIQE 437
F FI+E
Sbjct: 625 FIRFIEE 631
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 79.3 bits (194), Expect = 7e-15
Identities = 109/438 (24%), Positives = 173/438 (39%), Gaps = 95/438 (21%)
Query: 111 WASLTEYPRETFS-FVLTNVDGSRKIG--------YCRRLLP-----------------A 144
W T+YP FS FVLT + G Y R LL
Sbjct: 8 WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
Query: 145 GPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYP---------FMQGLREAA 195
K C++S F F K L + K +S++ +P FMQ +
Sbjct: 68 SKSINTNKCICLLSHWPFFEAFRKFLMFIYK---LSVSGPHPLPIEKHISHFMQNI---P 121
Query: 196 FPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVL 253
FP+P + L S + + L++P+ + L +FS+LL L E + +L
Sbjct: 122 FPSPQRPRILVQL---SVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLL 178
Query: 254 ERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRF 313
E KI+ + + L+ A A+++PF W YIP+ P SL A + P PF+VGV R+
Sbjct: 179 ESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY 238
Query: 314 QQEVMDSPMEEVLLVNLCEGTFLMSVGDEK-----DILPPKLQDDILDSLGQGINEL--- 365
+ P ++V+ ++L T ++ V DEK LP K ++L +L + +L
Sbjct: 239 FD--LHDPPQDVVCIDL--DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSV 294
Query: 366 --KTAE--------------------QINEHVSGPFVQFFVKIVGHYASYIK-------- 395
KT E Q+ + F++F I+ Y +Y++
Sbjct: 295 HQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSN 354
Query: 396 REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAE--KSKNPPAGYFQQKI 453
+ F + F K+ + +F KTQ+F FI+E K+ +F I
Sbjct: 355 KATAADSLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCI 413
Query: 454 LEYEEQKKQKKPREKTVK 471
E+ K EKT K
Sbjct: 414 ----EKLFPDKGTEKTDK 427
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 75.5 bits (184), Expect = 1e-13
Identities = 99/473 (20%), Positives = 186/473 (39%), Gaps = 96/473 (20%)
Query: 71 YEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE---WASLTEYPRETFS-FVL 126
YE + ++P+ +N E L +++P+FC P G W + T+YP FS FVL
Sbjct: 211 YEAELLGRYPEEDN-------EAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVL 263
Query: 127 TNVDGSRKIGYCRRLLPAGPGPRLP---------------------------KVYCIISC 159
T G + G + A P RL + ++S
Sbjct: 264 TGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSR 323
Query: 160 IGCFGLFSKILD-----EVEKRHQISM-AVIYPFMQGLREAAFPAPGKTVTLKSFIPDSG 213
F F L V H++ + A I F+ + FP+P + L P
Sbjct: 324 WPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSPYDN 380
Query: 214 TEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCI 271
+ L +P+ S L F LL L E + + + + E K++ + L+
Sbjct: 381 ---LLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVC 437
Query: 272 HAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLC 331
A ++++P W YIP+ P L + P PF+VG+ + + P +V+ V+L
Sbjct: 438 EALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLD 495
Query: 332 EGTFLMSVGDEKDILPP--------KLQDDILDSLGQGINELKTAEQ------------- 370
T + +EK +L P K+ L +L Q +++ T +
Sbjct: 496 TNTLFQT--EEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYE 553
Query: 371 --------INEHVSGPFVQFFVKIVGHYASYIK--REANGQGH------FQERSFCKALT 414
+ V G F++F ++ Y +++ +A +G F + F K+
Sbjct: 554 AVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-R 612
Query: 415 SKTNRRFVKKFVKTQLFSLFIQEAE--KSKNPPAGYFQQKILEYEEQKKQKKP 465
+++ + + + TQ+FS FI+E +++ +F + + ++++ +P
Sbjct: 613 ERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQEKPEP 665
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 74.3 bits (181), Expect = 2e-13
Identities = 84/356 (23%), Positives = 139/356 (39%), Gaps = 58/356 (16%)
Query: 56 YLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWASLT 115
++LV R + + I +FP+++ E+ + I LFC P G W
Sbjct: 8 FVLVAFGPHPRGSGEGQGQILQRFPEKD-------WEDNPFPQGIELFCQPSG--WQLCP 58
Query: 116 EY-PRETFSFVLTNVDGSRKIGYC-------------------------------RRLLP 143
E P F VLT+++ R C L P
Sbjct: 59 ERNPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSP 118
Query: 144 AGPGPRL----PKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQG-LREAAFPA 198
P P PK ++S + +F L + H + V + G L P
Sbjct: 119 TAPAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPL 178
Query: 199 PG---KTVTLKSFIPDSGTEFISLTRPLDS-HLEHVDFSSLLHCLSFEQILQIFASAVLE 254
G +T++L +G + T DS + + L L +L +F +A+ E
Sbjct: 179 AGGSQRTISL-----GAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTE 233
Query: 255 RKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQ 314
K++FL+ L+ ALL+P ++ TY+P++P LL + PTPF++GV FQ
Sbjct: 234 HKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQ 293
Query: 315 QEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDILDSLGQGIN-ELKTAE 369
E + + +V++ +L GT + LP LQ L ++ EL+ A+
Sbjct: 294 AETQE--LLDVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELAD 347
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 69.3 bits (168), Expect = 7e-12
Identities = 69/278 (24%), Positives = 110/278 (39%), Gaps = 40/278 (14%)
Query: 97 LKAIPLFCFPDGNEWASLTEYPRE--TFSFVLTNVDGSRKIG------------YC---R 139
L +P CFP G + P+E VLT+V G+R G YC
Sbjct: 39 LLTLPQLCFPGG---VCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNG 95
Query: 140 RLLPAGPGPRLPKVYCIIS----------CIGCFGLFSKILDEVEKRHQISMAVIYPFMQ 189
+ PG +P C++S C+ C K + E I F
Sbjct: 96 KTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIK-----DFAA 150
Query: 190 GLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLHCLSFEQILQIFA 249
L P PG + F S + +S + +D L C E++LQI
Sbjct: 151 KLSLIPSPPPGPLHLV--FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILT 208
Query: 250 SAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGV 309
+ E++I+F + + L+ A LYP W H ++P++ + +L V PT F++G
Sbjct: 209 CILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGC 268
Query: 310 QMRFQQEVMDSPMEEVLLVNLCEG--TFLMSVGDEKDI 345
+ +EV + ++L+N+ G T+ S D DI
Sbjct: 269 HLDHFEEV-SKEADGLVLINIDHGSITYSKSTDDNVDI 305
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 69.3 bits (168), Expect = 7e-12
Identities = 52/229 (22%), Positives = 100/229 (43%), Gaps = 25/229 (10%)
Query: 235 LLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPES 294
L L + +L +F + + E K++F + LS A +L++P +++ YIP++P
Sbjct: 202 LFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQ 261
Query: 295 LLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKLQDDI 354
LL + PTPF++GV F+ +V + + +V++ +L GT + LP L
Sbjct: 262 LLEVLSSPTPFIIGVHSVFKTDVHE--LLDVIIADLDGGTIKIPECIHLSSLPEPLLHQT 319
Query: 355 LDSLGQGIN---------------ELKTAEQINEHVSGPFVQFFVKIVGHYAS---YIKR 396
+L ++ L ++ +++ V F++ F ++ Y S I+
Sbjct: 320 QSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRI 379
Query: 397 EANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPP 445
A HF + +F F+ K + F+ F+ E + PP
Sbjct: 380 HAEPVIHFHKTAFL-GQRGLVENDFLTKVLSGMAFAGFVSE----RGPP 423
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 66.2 bits (160), Expect = 6e-11
Identities = 69/304 (22%), Positives = 108/304 (35%), Gaps = 82/304 (26%)
Query: 99 AIPLFCFPDGNEWASLTEYPRETF-SFVLTNVDGSRKIGYC----------------RRL 141
A+ + C P G + + T+ F SF++T DGSR G+ + L
Sbjct: 76 AVNMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTL 135
Query: 142 LPAGPGPRLPKVYCIISCIGCFGLFSKILDEVE----------KRHQISMAVIY------ 185
VY SC + LDE + + IS +Y
Sbjct: 136 YQMHNAEHYSSVYASSSC--SMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSIC 193
Query: 186 -----PFMQG-----------------------------LREAAFPAPGKTVTLKSFIPD 211
PFMQ L E P PG+++
Sbjct: 194 LITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFYGVY-- 251
Query: 212 SGTEFISLTRPLDSHLEHVDFS--SLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQ 269
E + RP S L D+ L E ++Q+F +LE +I+ ++ L
Sbjct: 252 ---EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMT 308
Query: 270 CIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMR--FQQEVMDSPMEEVLL 327
LL+PF W H Y+P++P SLL + P P+++G+Q + + ++ P E
Sbjct: 309 VAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQE---- 364
Query: 328 VNLC 331
NLC
Sbjct: 365 ANLC 368
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 65.1 bits (157), Expect = 1e-10
Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 7/121 (5%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDF--SSLLHCLSFEQILQIF 248
L E P PG+++ I RP + L DF + L E + Q+F
Sbjct: 248 LYEVPLPPPGRSLKFSGVYGP-----IICQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVG 308
A+LE +I+ ++ L AL++PF W H Y+P++P SLL + P P+++G
Sbjct: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
Query: 309 V 309
+
Sbjct: 363 L 363
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
++GV F +D M ++V LV+L
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,370,438
Number of Sequences: 37866
Number of extensions: 888676
Number of successful extensions: 2266
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2192
Number of HSP's gapped (non-prelim): 48
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.