Search of human proteins with 21361657

Search of human proteins with 21361657

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361657 protein disulfide-isomerase A3 precursor [Homo
sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]  1021   0.0  
gi|4758304 protein disulfide isomerase A4 [Homo sapiens]              345   4e-95
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s...   253   2e-67
gi|94966757 protein disulfide isomerase A2 [Homo sapiens]             206   5e-53
gi|28372543 protein disulfide isomerase-like, testis expressed [...   117   3e-26
gi|5031973 protein disulfide isomerase A6 [Homo sapiens]              110   3e-24
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ...   101   1e-21
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap...   101   1e-21
gi|38505222 thioredoxin domain containing 10 [Homo sapiens]            91   2e-18
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul...    84   3e-16
gi|5803121 protein disulfide isomerase A5 [Homo sapiens]               75   1e-13
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s...    74   3e-13
gi|54633317 thioredoxin domain containing 11 [Homo sapiens]            64   2e-10
gi|151101292 thioredoxin domain containing 1 [Homo sapiens]            63   5e-10
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa...    62   2e-09
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa...    62   2e-09
gi|21361403 thioredoxin 2 precursor [Homo sapiens]                     60   4e-09
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap...    60   4e-09
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap...    60   4e-09
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]           54   3e-07
gi|50592994 thioredoxin [Homo sapiens]                                 47   3e-05
gi|95113651 glutaredoxin 3 [Homo sapiens]                              42   0.001
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    41   0.002
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    41   0.002
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    41   0.002
gi|4759274 thioredoxin-like 1 [Homo sapiens]                           40   0.004
gi|148839372 thioredoxin domain containing 3 [Homo sapiens]            40   0.004
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa...    37   0.032
gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sa...    37   0.042
gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapi...    37   0.042

>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
          Length = 505

 Score = 1021 bits (2640), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC 60
           MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC
Sbjct: 1   MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC 60

Query: 61  KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT 120
           KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT
Sbjct: 61  KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRT 120

Query: 121 ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD 180
           ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD
Sbjct: 121 ADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD 180

Query: 181 NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENI 240
           NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENI
Sbjct: 181 NYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENI 240

Query: 241 FGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA 300
           FGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA
Sbjct: 241 FGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFA 300

Query: 301 VASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGN 360
           VASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGN
Sbjct: 301 VASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGN 360

Query: 361 LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG 420
           LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG
Sbjct: 361 LKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELG 420

Query: 421 EKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL 480
           EKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL
Sbjct: 421 EKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL 480

Query: 481 QREATNPPVIQEEKPKKKKKAQEDL 505
           QREATNPPVIQEEKPKKKKKAQEDL
Sbjct: 481 QREATNPPVIQEEKPKKKKKAQEDL 505


>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
          Length = 645

 Score =  345 bits (886), Expect = 4e-95
 Identities = 200/477 (41%), Positives = 287/477 (60%), Gaps = 23/477 (4%)

Query: 28  LELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI---VPLAKVD 84
           L LT +NF+  ++D   A ++LVEF+APWCGHCK+LAPEYE AA  L      +PLAKVD
Sbjct: 180 LVLTKENFDEVVND---ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVD 236

Query: 85  CTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEE 144
            TA T+   ++ VSGYPTLKIFR G     Y+GPR   GIV ++ +Q+GP S  + T ++
Sbjct: 237 ATAETDLAKRFDVSGYPTLKIFRKGRPYD-YNGPREKYGIVDYMIEQSGPPSKEILTLKQ 295

Query: 145 FKKFISD-KDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGI 203
            ++F+ D  D  I+G F      A+ ++  AA+NLR++Y+F HT    +      +   +
Sbjct: 296 VQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQL 355

Query: 204 ILFRPSHLTNKFEDKTVAYTEQKMTSGK-IKKFIQENIFGICPH--MTEDNKDLIQGKDL 260
           ++ +P    +K+E ++     Q  T    IK F+ +    +  H  ++ D K   + + L
Sbjct: 356 VVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTR-RPL 414

Query: 261 LIAYYDVDYEKNAKGSN-YWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLEST 319
           ++ YY VD+  + + +  +WR++V+ VAK F +      FA+A  + ++ E+ D GL S 
Sbjct: 415 VVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPE----YTFAIADEEDYAGEVKDLGL-SE 469

Query: 320 AGEIPVVAIRTAKGEKFVMQ-EEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPV 378
           +GE    AI    G+KF M+ EEF  D   L  F+  +  G LK  +KS+P+P++N GPV
Sbjct: 470 SGEDVNAAILDESGKKFAMEPEEFDSD--TLREFVTAFKKGKLKPVIKSQPVPKNNKGPV 527

Query: 379 KVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATA 438
           KVVV + FD IV +  KDVLIEFYAPWCGHCK LEP Y  L +K      +VIAKMDATA
Sbjct: 528 KVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATA 587

Query: 439 NDVPSP-YEVRGFPTIYFSPANKKLNPKKYEGG-RELSDFISYLQREATNPPVIQEE 493
           NDVPS  Y+V GFPTIYF+P+  K NP K+EGG R+L     +++  AT     +EE
Sbjct: 588 NDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEE 644



 Score =  103 bits (258), Expect = 3e-22
 Identities = 56/143 (39%), Positives = 90/143 (62%), Gaps = 13/143 (9%)

Query: 27  VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG---IVPLAKV 83
           VL L D NF++ ++D  +   +L+EF+APWCGHCK+ APEYE  A  LK     +P+AK+
Sbjct: 64  VLVLNDANFDNFVADKDT---VLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKI 120

Query: 84  DCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVP----- 138
           D T+ +   +++ VSGYPT+KI + G +A  Y+G RT + IV+ +++ + P   P     
Sbjct: 121 DATSASVLASRFDVSGYPTIKILKKG-QAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVT 179

Query: 139 -LRTEEEFKKFISDKDASIVGFF 160
            + T+E F + ++D D  +V F+
Sbjct: 180 LVLTKENFDEVVNDADIILVEFY 202



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 47/124 (37%), Positives = 72/124 (58%), Gaps = 7/124 (5%)

Query: 366 KSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKL-S 424
           + + +    +  V V+   NFD  V +++  VL+EFYAPWCGHCK   P+Y+++   L  
Sbjct: 52  EEDDLEVKEENGVLVLNDANFDNFVADKDT-VLLEFYAPWCGHCKQFAPEYEKIANILKD 110

Query: 425 KDPNIVIAKMDAT-ANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483
           KDP I +AK+DAT A+ + S ++V G+PTI      KK     YEG R   + ++ + RE
Sbjct: 111 KDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKV-RE 166

Query: 484 ATNP 487
            + P
Sbjct: 167 VSQP 170


>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
           sapiens]
          Length = 508

 Score =  253 bits (647), Expect = 2e-67
 Identities = 167/496 (33%), Positives = 257/496 (51%), Gaps = 43/496 (8%)

Query: 3   LRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKR 62
           LRR  L   VA L+ A        VL L   NF   ++   +   +LVEF+APWCGHCK 
Sbjct: 2   LRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALA---AHKYLLVEFYAPWCGHCKA 58

Query: 63  LAPEYEAAATRLKGI---VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA--YDG 117
           LAPEY  AA +LK     + LAKVD T  ++   +YGV GYPT+K FR+G+ A    Y  
Sbjct: 59  LAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTA 118

Query: 118 PRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASN 177
            R AD IV+ LKK+ GPA+  L      +  +   + +++GFF D  S++  +FL+AA  
Sbjct: 119 GREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEA 178

Query: 178 LRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQ 237
           + D+  F  T+   + ++Y  + +G++LF+      KF++    + E ++T   +  FI+
Sbjct: 179 I-DDIPFGITSNSDVFSKYQLDKDGVVLFK------KFDEGRNNF-EGEVTKENLLDFIK 230

Query: 238 ENIFGICPHMTEDNKDLIQGKDLL----------IAYYDVDYEKNAKGSNYWRNRVMMVA 287
            N   +    TE     I G ++           ++ YD         +  ++ +++ + 
Sbjct: 231 HNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFI- 289

Query: 288 KKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSR-DG 346
             F+D+ H  N  +         L  FGL+    E P V + T + E    + E      
Sbjct: 290 --FIDSDHTDNQRI---------LEFFGLKKE--ECPAVRLITLEEEMTKYKPESEELTA 336

Query: 347 KALERFLQDYFDGNLKRYLKSEPIPESNDG-PVKVVVAENFDEIVNNENKDVLIEFYAPW 405
           + +  F   + +G +K +L S+ +PE  D  PVKV+V +NF+++  +E K+V +EFYAPW
Sbjct: 337 ERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPW 396

Query: 406 CGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPK 465
           CGHCK L P + +LGE      NIVIAKMD+TAN+V +  +V  FPT+ F PA+      
Sbjct: 397 CGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEA-VKVHSFPTLKFFPASADRTVI 455

Query: 466 KYEGGRELSDFISYLQ 481
            Y G R L  F  +L+
Sbjct: 456 DYNGERTLDGFKKFLE 471



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 49/114 (42%), Positives = 70/114 (61%), Gaps = 4/114 (3%)

Query: 371 PESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPN-I 429
           PE  D  V V+   NF E +   +K +L+EFYAPWCGHCK L P+Y +   KL  + + I
Sbjct: 20  PEEEDH-VLVLRKSNFAEALA-AHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEI 77

Query: 430 VIAKMDATA-NDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQR 482
            +AK+DAT  +D+   Y VRG+PTI F       +PK+Y  GRE  D +++L++
Sbjct: 78  RLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKK 131


>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
          Length = 525

 Score =  206 bits (523), Expect = 5e-53
 Identities = 144/463 (31%), Positives = 229/463 (49%), Gaps = 33/463 (7%)

Query: 48  MLVEFFAPWCGHCKRLAPEYEAAATRLKG---IVPLAKVDCTANTNTCNKYGVSGYPTLK 104
           +LVEF+APWCGHC+ LAPEY  AA  L     +V LAKVD  A      ++GV+ YPTLK
Sbjct: 62  LLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLK 121

Query: 105 IFRDGEEA--GAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDD 162
            FR+G       Y GPR A+GI   L+++ GP+++ L  E   +  I  +D  ++GFF D
Sbjct: 122 FFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQD 181

Query: 163 SFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAY 222
              E  + FL  A +  D   F  T+   L  ++    + ++LF+      KF++    +
Sbjct: 182 LQDEDVATFLALAQDALD-MTFGLTDRPRLFQQFGLTKDTVVLFK------KFDEGRADF 234

Query: 223 ---TEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYW 279
               E  +  G + +F+  +   +   +TE N    Q    + A   +++          
Sbjct: 235 PVDEELGLDLGDLSRFLVTHSMRL---VTEFNS---QTSAKIFAARILNHLLLFVNQTLA 288

Query: 280 RNRVMM-----VAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAG-EIPVVAIRTAKG 333
            +R ++      A +F   G  L   V       H L  FGL++ A   + +V + T K 
Sbjct: 289 AHRELLAGFGEAAPRF--RGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTK- 345

Query: 334 EKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESND-GPVKVVVAENFDEIVNN 392
            K+   +       ++  F     +G +K YL S+ IP   D  PVK +V +NF+++  +
Sbjct: 346 -KYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFD 404

Query: 393 ENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPT 452
           E K+V ++FYAPWC HCK + P ++ L EK     +I+IA++DATAN++ + + V GFPT
Sbjct: 405 ETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDA-FAVHGFPT 463

Query: 453 IYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKP 495
           + + PA       +Y+  R+L  F  +L      P     E+P
Sbjct: 464 LKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEP 506



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 31/92 (33%), Positives = 54/92 (58%), Gaps = 2/92 (2%)

Query: 393 ENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIV-IAKMDATA-NDVPSPYEVRGF 450
           E+  +L+EFYAPWCGHC+ L P+Y +    L+ +  +V +AK+D  A  ++   + V  +
Sbjct: 58  EHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEY 117

Query: 451 PTIYFSPANKKLNPKKYEGGRELSDFISYLQR 482
           PT+ F     + +P++Y G R+      +L+R
Sbjct: 118 PTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRR 149



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 2/83 (2%)

Query: 27  VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCT 86
           V  L   NFE    D      + V+F+APWC HCK +AP +EA A + +    +   +  
Sbjct: 390 VKTLVGKNFEQVAFDETKN--VFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELD 447

Query: 87  ANTNTCNKYGVSGYPTLKIFRDG 109
           A  N  + + V G+PTLK F  G
Sbjct: 448 ATANELDAFAVHGFPTLKYFPAG 470


>gi|28372543 protein disulfide isomerase-like, testis expressed
           [Homo sapiens]
          Length = 584

 Score =  117 bits (292), Expect = 3e-26
 Identities = 106/450 (23%), Positives = 192/450 (42%), Gaps = 38/450 (8%)

Query: 48  MLVEFFAPWCGHCKRLAPEYEAAATRL---KGIVPLAKVDCTANTNTCNKYGVSGYPTLK 104
           ++V F  P     + LA E   A   +   K  +   KVD T       ++G++  P LK
Sbjct: 63  LMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDITIEKELQQEFGITKAPELK 122

Query: 105 IFRDGE--EAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDD 162
           +F +G   E  +  G   +  +V  L++Q    +    + E+  +F+  +   IVGFF D
Sbjct: 123 LFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFLFNSSEQVAEFVISRPLVIVGFFQD 182

Query: 163 SFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAY 222
              E    F     +  +   F    + +++  +    + +++F+   + N+   K +  
Sbjct: 183 LEEEVAELFYDVIKDFPE-LTFGVITIGNVIGRFHVTLDSVLVFKKGKIVNR--QKLIND 239

Query: 223 TEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAY----------YDVDYEKN 272
           +  K    ++ + I++++         +NKDLI    ++             Y +  +  
Sbjct: 240 STNKQ---ELNRVIKQHLTDFVIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHY 296

Query: 273 AKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAK 332
              S  ++N+++ +    +DA    N  V     F +         T  +IP V I    
Sbjct: 297 KLASKEFQNKILFI---LVDADEPRNGRV-----FKY------FRVTEVDIPSVQILNLS 342

Query: 333 GEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESND-GPVKVVVAENFDEIVN 391
            +            ++L++F + +   N  ++  SE IP+  D G VK +V +NF+ +V 
Sbjct: 343 SDARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQGLVKQLVGKNFNVVVF 402

Query: 392 NENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFP 451
           ++ KDV + FYAPW   CK L P  +ELG K      I+IAK+D TAND+   Y  R +P
Sbjct: 403 DKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTANDIQLMYLDR-YP 461

Query: 452 TIYFSPANKKLNPKKYEGGRELSDFISYLQ 481
                P+  +     Y+G   L  F  +L+
Sbjct: 462 FFRLFPSGSQ-QAVLYKGEHTLKGFSDFLE 490


>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
          Length = 440

 Score =  110 bits (275), Expect = 3e-24
 Identities = 63/174 (36%), Positives = 93/174 (53%), Gaps = 14/174 (8%)

Query: 22  AAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLK----GI 77
           ++  DV+ELTDD+F+  + D  S  + +VEF+APWCGHCK L PE+ AAA+ +K    G 
Sbjct: 157 SSKKDVIELTDDSFDKNVLD--SEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGK 214

Query: 78  VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHL-----KKQA 132
           V LA VD T N    ++YG+ G+PT+KIF+ GE    YDG RT   IVS           
Sbjct: 215 VKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAP 274

Query: 133 GPASVPLRTEEEFKKFISDKDASIVGFFD---DSFSEAHSEFLKAASNLRDNYR 183
            P  + +  E+  K+   +    +V       D+ +   + +L+    L D Y+
Sbjct: 275 PPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYK 328



 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 12/175 (6%)

Query: 1   MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC 60
           M L  L L      L      +++ DV+ELT  NF   +  + S  L LVEF+APWCGHC
Sbjct: 1   MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAPWCGHC 58

Query: 61  KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPR 119
           +RL PE++ AAT LK +V +  VD   + +   +YGV G+PT+KIF   +     Y G R
Sbjct: 59  QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGR 118

Query: 120 TADGIVSH--------LKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSE 166
           T + IV          +K + G  S    + ++ +   S K   ++   DDSF +
Sbjct: 119 TGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSK-KDVIELTDDSFDK 172



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 49/136 (36%), Positives = 72/136 (52%), Gaps = 7/136 (5%)

Query: 348 ALERFLQDYFDGNLKRYL--KSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPW 405
           AL + ++D   G    Y   K      S+   V  +  ++FD+ V +     ++EFYAPW
Sbjct: 130 ALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPW 189

Query: 406 CGHCKNLEPKYKELGEKLSKDP--NIVIAKMDATANDV-PSPYEVRGFPTIYFSPANKKL 462
           CGHCKNLEP++     ++ +     + +A +DAT N V  S Y +RGFPTI      K  
Sbjct: 190 CGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKI--FQKGE 247

Query: 463 NPKKYEGGRELSDFIS 478
           +P  Y+GGR  SD +S
Sbjct: 248 SPVDYDGGRTRSDIVS 263



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 38/100 (38%), Positives = 56/100 (56%), Gaps = 4/100 (4%)

Query: 373 SNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIA 432
           S+   V  +   NF+  V   +   L+EFYAPWCGHC+ L P++K+    L KD  + + 
Sbjct: 22  SSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATAL-KDV-VKVG 79

Query: 433 KMDATA-NDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGR 471
            +DA   + +   Y V+GFPTI    +NK   P+ Y+GGR
Sbjct: 80  AVDADKHHSLGGQYGVQGFPTIKIFGSNKN-RPEDYQGGR 118


>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
           [Homo sapiens]
          Length = 432

 Score =  101 bits (252), Expect = 1e-21
 Identities = 55/127 (43%), Positives = 76/127 (59%), Gaps = 9/127 (7%)

Query: 10  PGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
           P  A +LAA   A    VL LT++NF+    DT + G+  ++F+APWCGHCK LAP +E 
Sbjct: 307 PSEAPVLAAEPEADKGTVLALTENNFD----DTIAEGITFIKFYAPWCGHCKTLAPTWEE 362

Query: 70  AATR----LKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125
            + +    L G V +A+VDCTA  N C+KY V GYPTL +FR G++   + G R  D + 
Sbjct: 363 LSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLH 421

Query: 126 SHLKKQA 132
             +  QA
Sbjct: 422 RFVLSQA 428



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 38/74 (51%), Positives = 50/74 (67%), Gaps = 4/74 (5%)

Query: 50  VEFFAPWCGHCKRLAPEYEAAATRLKGI----VPLAKVDCTANTNTCNKYGVSGYPTLKI 105
           V FFAPWCGHC+RL P +     +   +    V +AKVDCTA+++ C+  GV GYPTLK+
Sbjct: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141

Query: 106 FRDGEEAGAYDGPR 119
           F+ G+EA  Y GPR
Sbjct: 142 FKPGQEAVKYQGPR 155



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 6/105 (5%)

Query: 29  ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCT 86
           EL+  NFE  ++     G   ++FFAPWCGHCK LAP +E  A  L+    V + KVDCT
Sbjct: 193 ELSASNFELHVAQ----GDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCT 248

Query: 87  ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131
            +   C+   V GYPTL  FRDG++   Y G R  + +  +++ Q
Sbjct: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 27/164 (16%)

Query: 344 RDGKALERF--------LQDYFDGNLKR--------YLKSE-PI----PESNDGPVKVVV 382
           RDGK ++++        L++Y +  L+R           SE P+    PE++ G V  + 
Sbjct: 269 RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALT 328

Query: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK-LSKDPNIVIAKMDATA-ND 440
             NFD+ +        I+FYAPWCGHCK L P ++EL +K       + IA++D TA  +
Sbjct: 329 ENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386

Query: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREA 484
           + S Y VRG+PT+      KK++  ++ GGR+L     ++  +A
Sbjct: 387 ICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSLHRFVLSQA 428



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 7/98 (7%)

Query: 399 IEFYAPWCGHCKNLEPKYKELGEKLS--KDPNIVIAKMDATA-NDVPSPYEVRGFPTI-Y 454
           + F+APWCGHC+ L+P + +LG+K +  +D  + +AK+D TA +DV S   VRG+PT+  
Sbjct: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141

Query: 455 FSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQE 492
           F P  + +   KY+G R+     +++ +     PV  E
Sbjct: 142 FKPGQEAV---KYQGPRDFQTLENWMLQTLNEEPVTPE 176



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%)

Query: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DV 441
           A NF+  ++    D  I+F+APWCGHCK L P +++L   L     + I K+D T + ++
Sbjct: 196 ASNFE--LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYEL 253

Query: 442 PSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483
            S  +VRG+PT+ +    KK++  +Y+G R+L     Y++ +
Sbjct: 254 CSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQ 293


>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
           sapiens]
          Length = 324

 Score =  101 bits (252), Expect = 1e-21
 Identities = 55/127 (43%), Positives = 76/127 (59%), Gaps = 9/127 (7%)

Query: 10  PGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
           P  A +LAA   A    VL LT++NF+    DT + G+  ++F+APWCGHCK LAP +E 
Sbjct: 199 PSEAPVLAAEPEADKGTVLALTENNFD----DTIAEGITFIKFYAPWCGHCKTLAPTWEE 254

Query: 70  AATR----LKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125
            + +    L G V +A+VDCTA  N C+KY V GYPTL +FR G++   + G R  D + 
Sbjct: 255 LSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLH 313

Query: 126 SHLKKQA 132
             +  QA
Sbjct: 314 RFVLSQA 320



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 6/105 (5%)

Query: 29  ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCT 86
           EL+  NFE  ++     G   ++FFAPWCGHCK LAP +E  A  L+    V + KVDCT
Sbjct: 85  ELSASNFELHVAQ----GDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCT 140

Query: 87  ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131
            +   C+   V GYPTL  FRDG++   Y G R  + +  +++ Q
Sbjct: 141 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 185



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 27/164 (16%)

Query: 344 RDGKALERF--------LQDYFDGNLKR--------YLKSE-PI----PESNDGPVKVVV 382
           RDGK ++++        L++Y +  L+R           SE P+    PE++ G V  + 
Sbjct: 161 RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALT 220

Query: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK-LSKDPNIVIAKMDATA-ND 440
             NFD+ +        I+FYAPWCGHCK L P ++EL +K       + IA++D TA  +
Sbjct: 221 ENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 278

Query: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREA 484
           + S Y VRG+PT+      KK++  ++ GGR+L     ++  +A
Sbjct: 279 ICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSLHRFVLSQA 320



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%)

Query: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DV 441
           A NF+  ++    D  I+F+APWCGHCK L P +++L   L     + I K+D T + ++
Sbjct: 88  ASNFE--LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYEL 145

Query: 442 PSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483
            S  +VRG+PT+ +    KK++  +Y+G R+L     Y++ +
Sbjct: 146 CSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQ 185



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 25/42 (59%), Positives = 33/42 (78%)

Query: 78  VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPR 119
           V +AKVDCTA+++ C+  GV GYPTLK+F+ G+EA  Y GPR
Sbjct: 6   VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPR 47


>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
          Length = 454

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 83/360 (23%), Positives = 161/360 (44%), Gaps = 38/360 (10%)

Query: 18  AARLAAASDVLELT---------DDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYE 68
           A RL A   VL++          D++F+   +D     + LV+F+APWCGHCK+L P + 
Sbjct: 9   ALRLCATVVVLDMVVCKGFVEDLDESFKENRNDD----IWLVDFYAPWCGHCKKLEPIWN 64

Query: 69  AAATRLKGI---VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125
                +K I   V + K+D T+ ++  +++GV GYPT+K+ + G+ A  Y GPRT D I+
Sbjct: 65  EVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLK-GDLAYNYRGPRTKDDII 123

Query: 126 SHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFA 185
               + +G    PL +++ F+     K   +   +    S    +++ AAS L   Y + 
Sbjct: 124 EFAHRVSGALIRPLPSQQMFEHM--QKRHRVFFVYVGGESPLKEKYIDAASEL-IVYTYF 180

Query: 186 HTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICP 245
            +  E +V EY       +  +       F+D+T  +   +   G +  +I    F    
Sbjct: 181 FSASEEVVPEY-------VTLKEMPAVLVFKDETY-FVYDEYEDGDLSSWINRERFQ--N 230

Query: 246 HMTEDNKDLIQGKDL--LIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHK-LNFAVA 302
           ++  D   L +  D   L+A   +D +  +      ++ +  VA+ + D  H+   F   
Sbjct: 231 YLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHM 290

Query: 303 SRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLK 362
               + + L    L      +P V +     +++ + +   ++ + + +F+ +  DG ++
Sbjct: 291 DGNDYINTLLMDEL-----TVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVE 345



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 43/103 (41%), Positives = 58/103 (56%), Gaps = 7/103 (6%)

Query: 384 ENFDE-IVNNENKDV-LIEFYAPWCGHCKNLEPKYKELG-EKLSKDPNIVIAKMDATA-N 439
           E+ DE    N N D+ L++FYAPWCGHCK LEP + E+G E  S    + + KMDAT+ +
Sbjct: 29  EDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYS 88

Query: 440 DVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQR 482
            + S + VRG+PTI     +   N   Y G R   D I +  R
Sbjct: 89  SIASEFGVRGYPTIKLLKGDLAYN---YRGPRTKDDIIEFAHR 128


>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
           [Homo sapiens]
          Length = 406

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 87/370 (23%), Positives = 162/370 (43%), Gaps = 33/370 (8%)

Query: 14  LLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATR 73
           LL+        +++  L  +N +  +++   A + LV F+A WC   + L P +E A+  
Sbjct: 18  LLVTWVFTPVTTEITSLDTENIDEILNN---ADVALVNFYADWCRFSQMLHPIFEEASDV 74

Query: 74  LKGIVP------LAKVDCTANTNTCNKYGVSGYPTLKIFRDG-EEAGAYDGPRTADGIVS 126
           +K   P       A+VDC  +++   +Y +S YPTLK+FR+G      Y G R+   +  
Sbjct: 75  IKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALAD 134

Query: 127 HLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAH 186
           ++++Q       +R   E       K  +I+G+F+   S+ +  F + A+ L D+  F  
Sbjct: 135 YIRQQKSDPIQEIRDLAEITTLDRSK-RNIIGYFEQKDSDNYRVFERVANILHDDCAFLS 193

Query: 187 TNVE-SLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICP 245
              + S    Y  +G+ II   P H         + Y            +IQ+    +  
Sbjct: 194 AFGDVSKPERY--SGDNIIYKPPGH-----SAPDMVYLGAMTNFDVTYNWIQDKCVPLVR 246

Query: 246 HMTEDNKDLI--QGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVAS 303
            +T +N + +  +G   LI ++    +++ +    ++N    VA++ +     +NF  A 
Sbjct: 247 EITFENGEELTEEGLPFLILFH---MKEDTESLEIFQNE---VARQLISEKGTINFLHAD 300

Query: 304 RKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQE--EFSRDGKALERFLQDYFDGNL 361
              F H L    ++ T  + PV+AI + +   +V  +  +    GK L++F+ D   G L
Sbjct: 301 CDKFRHPL--LHIQKTPADCPVIAIDSFR-HMYVFGDFKDVLIPGK-LKQFVFDLHSGKL 356

Query: 362 KRYLKSEPIP 371
            R     P P
Sbjct: 357 HREFHHGPDP 366



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 34/114 (29%), Positives = 62/114 (54%), Gaps = 9/114 (7%)

Query: 384 ENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKD-PN---IVIAKMDATA- 438
           EN DEI+NN +   L+ FYA WC   + L P ++E  + + ++ PN   +V A++D    
Sbjct: 37  ENIDEILNNADV-ALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQH 95

Query: 439 NDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQE 492
           +D+   Y +  +PT+     N  +  ++Y G R +     Y++++ ++P  IQE
Sbjct: 96  SDIAQRYRISKYPTLKLF-RNGMMMKREYRGQRSVKALADYIRQQKSDP--IQE 146


>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
          Length = 519

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 38/89 (42%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 27  VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVP----LAK 82
           V  LTD++F+  + +  S   +LV F APWCGHCK++ PE+E AA  L G       LA 
Sbjct: 278 VYHLTDEDFDQFVKEHSS---VLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334

Query: 83  VDCTANTNTCNKYGVSGYPTLKIFRDGEE 111
           VD T N     ++ +S +PTLK F++GE+
Sbjct: 335 VDATVNKALAERFHISEFPTLKYFKNGEK 363



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 53/174 (30%), Positives = 82/174 (47%), Gaps = 20/174 (11%)

Query: 24  ASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKV 83
           A DV+ L  +    R+       L+++ F+APWC  CKR+ P ++ AAT+L+G   LA +
Sbjct: 150 AKDVVHLDSEKDFRRLLKKEEKPLLIM-FYAPWCSMCKRMMPHFQKAATQLRGHAVLAGM 208

Query: 84  DCTAN--TNTCNKYGVSGYPTLKIFRDGEEAGAYDG-PRTADGIVSHLKKQAGP------ 134
           +  ++   N   +Y V G+PT+  F  G     YD    TA+ IV  LK    P      
Sbjct: 209 NVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPE 268

Query: 135 -------ASVPLRTEEEFKKFISDKDASIVGF---FDDSFSEAHSEFLKAASNL 178
                   SV   T+E+F +F+ +  + +V F   +     +   EF KAA  L
Sbjct: 269 TPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEAL 322



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 38/109 (34%), Positives = 53/109 (48%), Gaps = 7/109 (6%)

Query: 25  SDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAK 82
           + VL L  DNF   +         LV F+APWC HCK++ P + A A   K    +  A 
Sbjct: 397 TSVLHLVGDNFRETLKKKKHT---LVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAA 453

Query: 83  VDCT--ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLK 129
           VDC    N + C +  V GYPT   +  G+ A  YD  RT  G  ++++
Sbjct: 454 VDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIR 502



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 40/117 (34%), Positives = 62/117 (52%), Gaps = 9/117 (7%)

Query: 376 GPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKL--SKDPNIVIAK 433
           G V  +  E+FD+ V  E+  VL+ F+APWCGHCK ++P++++  E L    D + V+A 
Sbjct: 276 GSVYHLTDEDFDQFVK-EHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAA 334

Query: 434 MDATAND-VPSPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFISYLQREATNPP 488
           +DAT N  +   + +  FPT+ YF    K   P      R    F+ ++Q     PP
Sbjct: 335 VDATVNKALAERFHISEFPTLKYFKNGEKYAVPVL----RTKKKFLEWMQNPEAPPP 387



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 99/464 (21%), Positives = 178/464 (38%), Gaps = 85/464 (18%)

Query: 71  ATRLKGIVPLAKVDC--TANTNTCNKYGVSGYPTLKI-----FRDGEEAGAYDGPRTADG 123
           A  +KG   +  VDC    +   C K  V   P  K      ++DG     Y+   T   
Sbjct: 71  AQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKS 130

Query: 124 IVSHLKKQAGPAS----------VPLRTEEEFKKFISDKDASIVGFFDDSF----SEAHS 169
           IV+ LK   GP            V L +E++F++ +  ++  ++  F   +         
Sbjct: 131 IVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMP 190

Query: 170 EFLKAASNLRDNYRFAHTNV-----ESLVNEYDDNG--------EGIILFRPSHLTNKFE 216
            F KAA+ LR +   A  NV     E++  EY   G        +G  LF+  +  +  E
Sbjct: 191 HFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAE 250

Query: 217 DKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLI--QGKDLLIAYYDVDYEKNAK 274
           D        +    ++ +    +  G   H+T+++ D    +   +L+ ++         
Sbjct: 251 DIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAP------- 303

Query: 275 GSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVV--AIRTAK 332
               W      +  +F  A   L+                G   ++G +  V   +  A 
Sbjct: 304 ----WCGHCKKMKPEFEKAAEALH----------------GEADSSGVLAAVDATVNKAL 343

Query: 333 GEKFVMQE----EFSRDG--------KALERFLQDYFDGNLKRYLKSEPIPESNDGPVKV 380
            E+F + E    ++ ++G        +  ++FL+  +  N +     EP  E     V  
Sbjct: 344 AERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLE--WMQNPEAPPPPEPTWEEQQTSVLH 401

Query: 381 VVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN- 439
           +V +NF E +  + K  L+ FYAPWC HCK + P +    +    D  I  A +D   + 
Sbjct: 402 LVGDNFRETLKKK-KHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDK 460

Query: 440 --DVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQ 481
             D+     V+G+PT ++    K    +KY+  R    F +Y++
Sbjct: 461 NQDLCQQEAVKGYPTFHYYHYGK--FAEKYDSDRTELGFTNYIR 502



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 11/134 (8%)

Query: 366 KSEPIPESNDGPVKVVVAEN---FDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK 422
           K  P+ E + G   VV  ++   F  ++  E K +LI FYAPWC  CK + P +++   +
Sbjct: 139 KGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQ 198

Query: 423 LSKDPNIVIAKMDATAND---VPSPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFIS 478
           L    + V+A M+  +++   +   Y VRGFPTI YF           Y  G    D + 
Sbjct: 199 LR--GHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNY--GSTAEDIVE 254

Query: 479 YLQREATNPPVIQE 492
           +L+      P + E
Sbjct: 255 WLKNPQPPQPQVPE 268


>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
           sapiens]
          Length = 793

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 7/147 (4%)

Query: 15  LLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL 74
           +LA A+ +  S V  L   NF +   +       LV+FFAPWC  C+ L PE   A+  L
Sbjct: 443 ILAFAKESVNSHVTTLGPQNFPANDKEP-----WLVDFFAPWCPPCRALLPELRRASNLL 497

Query: 75  KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGP 134
            G +    +DCT +   CN Y +  YPT  +F        Y+G  +A+ I+  ++    P
Sbjct: 498 YGQLKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQ-SNIHEYEGHHSAEQILEFIEDLMNP 556

Query: 135 ASVPLRTEEEFKKFISDKDASIVGFFD 161
           + V L T   F + ++ +  + V   D
Sbjct: 557 SVVSL-TPTTFNELVTQRKHNEVWMVD 582



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 2/78 (2%)

Query: 29  ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTAN 88
           +LT   F  ++         +++F+APWCG C+  APE+E  A  +KG V   KVDC A 
Sbjct: 674 DLTPQTFSEKVLQ--GKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAY 731

Query: 89  TNTCNKYGVSGYPTLKIF 106
             TC K G+  YPT+K +
Sbjct: 732 AQTCQKAGIRAYPTVKFY 749



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 32/101 (31%), Positives = 53/101 (52%), Gaps = 3/101 (2%)

Query: 26  DVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDC 85
           +++ L    F++ ++   S  L  V F++P C HC  LAP +   A  + G++ +  V+C
Sbjct: 130 EIITLERREFDAAVN---SGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVNC 186

Query: 86  TANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVS 126
             +   C   GV+ YP+L IFR G     Y G R+ + +VS
Sbjct: 187 GDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVS 227



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 23/80 (28%), Positives = 42/80 (52%)

Query: 27  VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCT 86
           V+ LT   F   ++      + +V+F++PWC  C+ L PE++  A  L G++ +  +DC 
Sbjct: 558 VVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQ 617

Query: 87  ANTNTCNKYGVSGYPTLKIF 106
              + C +  V  YP ++ F
Sbjct: 618 QYHSFCAQENVQRYPEIRFF 637



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/121 (23%), Positives = 59/121 (48%), Gaps = 12/121 (9%)

Query: 372 ESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431
           ES +  V  +  +NF     N+ +  L++F+APWC  C+ L P+ +     L     +  
Sbjct: 449 ESVNSHVTTLGPQNFPA---NDKEPWLVDFFAPWCPPCRALLPELRRASNLLY--GQLKF 503

Query: 432 AKMDATAND-VPSPYEVRGFP-TIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPV 489
             +D T ++ + + Y ++ +P T+ F+ +    N  +YEG       + +++ +  NP V
Sbjct: 504 GTLDCTVHEGLCNMYNIQAYPTTVVFNQS----NIHEYEGHHSAEQILEFIE-DLMNPSV 558

Query: 490 I 490
           +
Sbjct: 559 V 559



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 3/73 (4%)

Query: 384 ENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATA-NDVP 442
           + F E V       +I+FYAPWCG C+N  P+++ L   +     +   K+D  A     
Sbjct: 678 QTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIK--GKVKAGKVDCQAYAQTC 735

Query: 443 SPYEVRGFPTIYF 455
               +R +PT+ F
Sbjct: 736 QKAGIRAYPTVKF 748



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 7/89 (7%)

Query: 386 FDEIVNNE--NKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATA-NDVP 442
           F+E+V     N+  +++FY+PWC  C+ L P++K +   L+   N  +  +D    +   
Sbjct: 566 FNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLIN--VGSIDCQQYHSFC 623

Query: 443 SPYEVRGFPTIYFSP--ANKKLNPKKYEG 469
           +   V+ +P I F P  +NK  +   Y G
Sbjct: 624 AQENVQRYPEIRFFPPKSNKAYHYHSYNG 652



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 23/107 (21%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 374 NDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAK 433
           +D  +  +    FD  VN+  +   + FY+P C HC +L P +++  +++  D  + I  
Sbjct: 127 DDPEIITLERREFDAAVNS-GELWFVNFYSPGCSHCHDLAPTWRDFAKEV--DGLLRIGA 183

Query: 434 MDATANDVPSPYE-VRGFPTIYFSPANKKLNPKKYEGGRELSDFISY 479
           ++   + +    + V  +P+++   +   + P KY G R     +S+
Sbjct: 184 VNCGDDRMLCRMKGVNSYPSLFIFRSG--MAPVKYHGDRSKESLVSF 228


>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
          Length = 958

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 42/124 (33%), Positives = 65/124 (52%), Gaps = 9/124 (7%)

Query: 349 LERFLQDY--FDGNLKRYL---KSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYA 403
           LE F+Q++      LKR+L    S   P  +   +  V  + F E+V  + +DVL+ +YA
Sbjct: 633 LESFIQNFSVLYSPLKRHLIGSGSAQFPSQH--LITEVTTDTFWEVVL-QKQDVLLLYYA 689

Query: 404 PWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLN 463
           PWCG C +L   + +L   L  D    +A++D + ND+P  + V   PT+ F P N+K  
Sbjct: 690 PWCGFCPSLNHIFIQLARNLPMD-TFTVARIDVSQNDLPWEFMVDRLPTVLFFPCNRKDL 748

Query: 464 PKKY 467
             KY
Sbjct: 749 SVKY 752



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 41/163 (25%), Positives = 73/163 (44%), Gaps = 6/163 (3%)

Query: 25  SDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVD 84
           S VL+L     +        + ++L+ F+APWCG       E E AA+RL   V    ++
Sbjct: 105 SPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAIN 164

Query: 85  CTANTNTCNKYGVSGY-PTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEE 143
           C  N   C K     Y P + ++        Y GP +A  I   +++   P  + + ++ 
Sbjct: 165 CWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPL-LYIPSQS 223

Query: 144 EFKKFISDKDASIVGFFDDSFSEAHSEFL----KAASNLRDNY 182
           E   F+S+ +  ++G+F+ S S     +L     A  +L+ +Y
Sbjct: 224 ELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDY 266



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 21/85 (24%), Positives = 35/85 (41%), Gaps = 2/85 (2%)

Query: 385 NFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSP 444
           ++ E V  +++ VL+ FYAPWCG       + ++   +LS     V              
Sbjct: 116 DYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQ 175

Query: 445 YEVRGFPTIYFSPANKKLNPKKYEG 469
                FP IY    ++   P +Y+G
Sbjct: 176 KHFFYFPVIYL--YHRSFGPIEYKG 198



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 29/117 (24%), Positives = 50/117 (42%), Gaps = 9/117 (7%)

Query: 27  VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL-KGIVPLAKVDC 85
           + E+T D F   +        +L+ ++APWCG C  L   +   A  L      +A++D 
Sbjct: 665 ITEVTTDTFWEVVLQKQD---VLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDV 721

Query: 86  TANTNTCNKYGVSGYPTLKIF----RDGEEAGAYDGPRTADGIVSHLKKQAGPASVP 138
           + N +   ++ V   PT+  F    +D       D P T   ++  +   + PAS P
Sbjct: 722 SQN-DLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSP 777


>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
          Length = 280

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 36/104 (34%), Positives = 59/104 (56%), Gaps = 8/104 (7%)

Query: 378 VKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDAT 437
           V+V+  EN+ E++     D +IEFYAPWC  C+NL+P+++   E   +D  + IAK+D T
Sbjct: 31  VRVITDENWRELLEG---DWMIEFYAPWCPACQNLQPEWESFAE-WGEDLEVNIAKVDVT 86

Query: 438 AN-DVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYL 480
               +   + +   PTIY     K    ++Y+G R   DFI+++
Sbjct: 87  EQPGLSGRFIITALPTIYHC---KDGEFRRYQGPRTKKDFINFI 127



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 35/116 (30%), Positives = 61/116 (52%), Gaps = 7/116 (6%)

Query: 25  SDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI-VPLAKV 83
           S+V  +TD+N+   +      G  ++EF+APWC  C+ L PE+E+ A   + + V +AKV
Sbjct: 29  SNVRVITDENWRELLE-----GDWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKV 83

Query: 84  DCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPL 139
           D T       ++ ++  PT+   +DG E   Y GPRT    ++ +  +   +  P+
Sbjct: 84  DVTEQPGLSGRFIITALPTIYHCKDG-EFRRYQGPRTKKDFINFISDKEWKSIEPV 138


>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
           sapiens]
          Length = 820

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 65/282 (23%), Positives = 120/282 (42%), Gaps = 27/282 (9%)

Query: 28  LELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKVDC 85
           LELT +  E   + T  A   +V F+A W          Y   A +LKG   + L +++C
Sbjct: 385 LELTVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINC 444

Query: 86  TANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVS--HLKKQAGPASVPLRTEE 143
              ++ C K  V+ +P +K+++ GE   +Y G    + ++    L + + P ++    E 
Sbjct: 445 ADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEA 504

Query: 144 E-------FKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD---NYRFAHTNVESLV 193
           E       +K  I     S++G F  +   A  +F +A + L+       ++  +V  L 
Sbjct: 505 EEYLSGELYKDLILYSSVSVLGLFSPTMKTAKEDFSEAGNYLKGYVITGIYSEEDVLLLS 564

Query: 194 NEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDN-- 251
            +Y  +   ++L R  H   K E   +A T  +     I + I + +  + P +T +N  
Sbjct: 565 TKYAASLPALLLAR--HTEGKIESIPLASTHAQ----DIVQIITDALLEMFPEITVENLP 618

Query: 252 KDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDA 293
                 K LLI + D           Y +  + +V +K+LD+
Sbjct: 619 SYFRLQKPLLILFSD-----GTVNPQYKKAILTLVKQKYLDS 655


>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
           sapiens]
          Length = 825

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 65/282 (23%), Positives = 120/282 (42%), Gaps = 27/282 (9%)

Query: 28  LELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI--VPLAKVDC 85
           LELT +  E   + T  A   +V F+A W          Y   A +LKG   + L +++C
Sbjct: 390 LELTVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINC 449

Query: 86  TANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVS--HLKKQAGPASVPLRTEE 143
              ++ C K  V+ +P +K+++ GE   +Y G    + ++    L + + P ++    E 
Sbjct: 450 ADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQEA 509

Query: 144 E-------FKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRD---NYRFAHTNVESLV 193
           E       +K  I     S++G F  +   A  +F +A + L+       ++  +V  L 
Sbjct: 510 EEYLSGELYKDLILYSSVSVLGLFSPTMKTAKEDFSEAGNYLKGYVITGIYSEEDVLLLS 569

Query: 194 NEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDN-- 251
            +Y  +   ++L R  H   K E   +A T  +     I + I + +  + P +T +N  
Sbjct: 570 TKYAASLPALLLAR--HTEGKIESIPLASTHAQ----DIVQIITDALLEMFPEITVENLP 623

Query: 252 KDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDA 293
                 K LLI + D           Y +  + +V +K+LD+
Sbjct: 624 SYFRLQKPLLILFSD-----GTVNPQYKKAILTLVKQKYLDS 660


>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
          Length = 166

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 37/128 (28%), Positives = 65/128 (50%), Gaps = 3/128 (2%)

Query: 6   LALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAP 65
           L + P  A  +   R++  +  ++   D F+ R+ ++ +   ++V+F A WCG CK L P
Sbjct: 42  LTVTPNPARTIYTTRISLTTFNIQDGPD-FQDRVVNSETP--VVVDFHAQWCGPCKILGP 98

Query: 66  EYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125
             E    +  G V +AKVD   +T+   +Y VS  PT+   ++G+    + G +  D + 
Sbjct: 99  RLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLE 158

Query: 126 SHLKKQAG 133
           + LKK  G
Sbjct: 159 AFLKKLIG 166



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 4/68 (5%)

Query: 387 DEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DVPSPY 445
           D +VN+E   V+++F+A WCG CK L P+ +++  K  +   +V+AK+D   + D+   Y
Sbjct: 72  DRVVNSETP-VVVDFHAQWCGPCKILGPRLEKMVAK--QHGKVVMAKVDIDDHTDLAIEY 128

Query: 446 EVRGFPTI 453
           EV   PT+
Sbjct: 129 EVSAVPTV 136


>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
           sapiens]
          Length = 604

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 29/70 (41%), Positives = 40/70 (57%), Gaps = 5/70 (7%)

Query: 43  GSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVP---LAKVDCTANTNT--CNKYGV 97
           GS     VEFFA WCGHC   AP ++A A  +K   P   LA +DC   TN+  C  + +
Sbjct: 56  GSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNI 115

Query: 98  SGYPTLKIFR 107
            G+PT++ F+
Sbjct: 116 PGFPTVRFFK 125



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 4/93 (4%)

Query: 373 SNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSK-DPNIVI 431
           S   P+ ++ A+     V        +EF+A WCGHC    P +K L E +    P + +
Sbjct: 37  SPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYL 96

Query: 432 AKMDA---TANDVPSPYEVRGFPTIYFSPANKK 461
           A +D    T + V   + + GFPT+ F  A  K
Sbjct: 97  AALDCAEETNSAVCRDFNIPGFPTVRFFKAFTK 129


>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
           sapiens]
          Length = 747

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 29/70 (41%), Positives = 40/70 (57%), Gaps = 5/70 (7%)

Query: 43  GSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVP---LAKVDCTANTNT--CNKYGV 97
           GS     VEFFA WCGHC   AP ++A A  +K   P   LA +DC   TN+  C  + +
Sbjct: 56  GSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNI 115

Query: 98  SGYPTLKIFR 107
            G+PT++ F+
Sbjct: 116 PGFPTVRFFK 125



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 4/93 (4%)

Query: 373 SNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSK-DPNIVI 431
           S   P+ ++ A+     V        +EF+A WCGHC    P +K L E +    P + +
Sbjct: 37  SPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYL 96

Query: 432 AKMDA---TANDVPSPYEVRGFPTIYFSPANKK 461
           A +D    T + V   + + GFPT+ F  A  K
Sbjct: 97  AALDCAEETNSAVCRDFNIPGFPTVRFFKAFTK 129


>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
          Length = 698

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 15/118 (12%)

Query: 5   RLALFPGVALLLAAA----------RLAAASDVLELTDDNFESRISDTGSAGLMLVEFFA 54
           R A  P + +LLAAA          RL  A +      D+   R +   S+   LV+F++
Sbjct: 29  RAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYS 88

Query: 55  PWCGHCKRLAPEYEAAATRLK---GIVPLAKVDCTANTN--TCNKYGVSGYPTLKIFR 107
            WCGHC   AP + A A  ++     + +A +DC    N   C+ Y +  YPT + F+
Sbjct: 89  SWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFK 146



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 33/117 (28%), Positives = 51/117 (43%), Gaps = 13/117 (11%)

Query: 392 NENKDVLIEFYAPWCGHCKNLEPKYKEL-GEKLSKDPNIVIAKMDATAND---VPSPYEV 447
           N +   L++FY+ WCGHC    P ++ L G+       I +A +D        V   Y++
Sbjct: 77  NSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDI 136

Query: 448 RGFPTI-YFSPANKKLNP-KKYEG-GREL----SDFISYLQR--EATNPPVIQEEKP 495
             +PT  YF    K+    + ++G  REL       I +LQ   E + PP      P
Sbjct: 137 HFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDP 193


>gi|50592994 thioredoxin [Homo sapiens]
          Length = 105

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 394 NKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDA-TANDVPSPYEVRGFPT 452
           +K V+++F A WCG CK ++P +  L EK S   N++  ++D     DV S  EV+  PT
Sbjct: 20  DKLVVVDFSATWCGPCKMIKPFFHSLSEKYS---NVIFLEVDVDDCQDVASECEVKCMPT 76

Query: 453 IYFSPANKKL 462
             F    +K+
Sbjct: 77  FQFFKKGQKV 86



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query: 41  DTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGY 100
           D     L++V+F A WCG CK + P + + + +   ++ L +VD     +  ++  V   
Sbjct: 16  DAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFL-EVDVDDCQDVASECEVKCM 74

Query: 101 PTLKIFRDGEEAGAYDG 117
           PT + F+ G++ G + G
Sbjct: 75  PTFQFFKKGQKVGEFSG 91


>gi|95113651 glutaredoxin 3 [Homo sapiens]
          Length = 335

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 31/125 (24%), Positives = 57/125 (45%), Gaps = 12/125 (9%)

Query: 383 AENFDEIVNNENKDVLI-EFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDAT-AND 440
           A  F+E++  + K +L+  F+APW   C  +     EL ++L   P +   K++A    +
Sbjct: 19  AGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL---PQVSFVKLEAEGVPE 75

Query: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKK 500
           V   YE+   PT  F   ++K++      G    +    +QR A++   +    P   + 
Sbjct: 76  VSEKYEISSVPTFLFFKNSQKIDRL---DGAHAPELTKKVQRHASSGSFL----PSANEH 128

Query: 501 AQEDL 505
            +EDL
Sbjct: 129 LKEDL 133



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 30/133 (22%), Positives = 52/133 (39%), Gaps = 2/133 (1%)

Query: 15  LLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL 74
           + A A  AA + V E+        +    +  L++V F+APW   C ++       A  L
Sbjct: 1   MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 60

Query: 75  KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGP 134
              V   K++         KY +S  PT   F++ ++    DG   A  +   +++ A  
Sbjct: 61  PQ-VSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAH-APELTKKVQRHASS 118

Query: 135 ASVPLRTEEEFKK 147
            S      E  K+
Sbjct: 119 GSFLPSANEHLKE 131


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 30  LTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANT 89
           L+ ++FE+ + + G   L+ V+F A WCG C+ + P + A + + + +V L +VD     
Sbjct: 387 LSKEDFEASLKEAGER-LVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCE 444

Query: 90  NTCNKYGVSGYPTLKIFRDGEEAGAYDG--PRTADGIVSHLK 129
               +  +   PT + ++  E+     G      + +++ LK
Sbjct: 445 EVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK 486



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 8/144 (5%)

Query: 323 IPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVV 382
           IP   I   K  +  +Q +     K+LE          LK   ++   PE +   VKV++
Sbjct: 330 IPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVIL 387

Query: 383 A-ENFDEIVNNENKD-VLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDA-TAN 439
           + E+F+  +    +  V ++F A WCG C+ + P +  L     K  ++V  ++DA    
Sbjct: 388 SKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS---VKHEDVVFLEVDADNCE 444

Query: 440 DVPSPYEVRGFPTIYFSPANKKLN 463
           +V     +   PT  F    +K++
Sbjct: 445 EVVRECAIMCVPTFQFYKKEEKVD 468


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 30  LTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANT 89
           L+ ++FE+ + + G   L+ V+F A WCG C+ + P + A + + + +V L +VD     
Sbjct: 454 LSKEDFEASLKEAGER-LVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCE 511

Query: 90  NTCNKYGVSGYPTLKIFRDGEEAGAYDG--PRTADGIVSHLK 129
               +  +   PT + ++  E+     G      + +++ LK
Sbjct: 512 EVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK 553



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 8/144 (5%)

Query: 323 IPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVV 382
           IP   I   K  +  +Q +     K+LE          LK   ++   PE +   VKV++
Sbjct: 397 IPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVIL 454

Query: 383 A-ENFDEIVNNENKD-VLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDA-TAN 439
           + E+F+  +    +  V ++F A WCG C+ + P +  L     K  ++V  ++DA    
Sbjct: 455 SKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS---VKHEDVVFLEVDADNCE 511

Query: 440 DVPSPYEVRGFPTIYFSPANKKLN 463
           +V     +   PT  F    +K++
Sbjct: 512 EVVRECAIMCVPTFQFYKKEEKVD 535


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/102 (23%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 30  LTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANT 89
           L+ ++FE+ + + G   L+ V+F A WCG C+ + P + A + + + +V L +VD     
Sbjct: 387 LSKEDFEASLKEAGER-LVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCE 444

Query: 90  NTCNKYGVSGYPTLKIFRDGEEAGAYDG--PRTADGIVSHLK 129
               +  +   PT + ++  E+     G      + +++ LK
Sbjct: 445 EVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK 486



 Score = 37.4 bits (85), Expect = 0.032
 Identities = 35/144 (24%), Positives = 63/144 (43%), Gaps = 8/144 (5%)

Query: 323 IPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVV 382
           IP   I   K  +  +Q +     K+LE          LK   ++   PE +   VKV++
Sbjct: 330 IPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDK--VKVIL 387

Query: 383 A-ENFDEIVNNENKD-VLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDA-TAN 439
           + E+F+  +    +  V ++F A WCG C+ + P +  L     K  ++V  ++DA    
Sbjct: 388 SKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS---VKHEDVVFLEVDADNCE 444

Query: 440 DVPSPYEVRGFPTIYFSPANKKLN 463
           +V     +   PT  F    +K++
Sbjct: 445 EVVRECAIMCVPTFQFYKKEEKVD 468


>gi|4759274 thioredoxin-like 1 [Homo sapiens]
          Length = 289

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 5/106 (4%)

Query: 31  TDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTN 90
           +D +F+  +S  GS  L +V+F    CG C R+AP + + + +    V L +VD      
Sbjct: 9   SDPDFQPELSGAGSR-LAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFL-EVDVHQCQG 66

Query: 91  TCNKYGVSGYPTLKIFRDGEEAGAYDGPRTA---DGIVSHLKKQAG 133
           T     +S  PT   FR+      Y G       + I  HL+   G
Sbjct: 67  TAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPG 112


>gi|148839372 thioredoxin domain containing 3 [Homo sapiens]
          Length = 588

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 1/75 (1%)

Query: 386 FDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPY 445
           +DE++ N+   V I+ Y  WCG C+ ++P +++L  +L++D  +  A  +A       P+
Sbjct: 20  WDEMLQNKGLTV-IDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPF 78

Query: 446 EVRGFPTIYFSPANK 460
             +  P   FS   K
Sbjct: 79  RDKCEPVFLFSVNGK 93


>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
           sapiens]
          Length = 349

 Score = 37.4 bits (85), Expect = 0.032
 Identities = 35/140 (25%), Positives = 63/140 (45%), Gaps = 11/140 (7%)

Query: 10  PGVALLLAA--ARLAAASDVLELTDDNFESRISDTGSAGLMLV-------EFFAPWCGHC 60
           P +  LLAA  A +AA +   E      +SR+    ++   LV       +F+APWC  C
Sbjct: 8   PQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTLVMEGEWMLKFYAPWCPSC 67

Query: 61  KRLAPEYEAAATRLKGI-VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPR 119
           ++   E+EA A   + + + + KVD         ++ V+  P     +DG     Y GP 
Sbjct: 68  QQTDSEWEAFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG-IFRRYRGPG 126

Query: 120 TADGIVSHLKKQAGPASVPL 139
             + + +++ ++   +  PL
Sbjct: 127 IFEDLQNYILEKKWQSVEPL 146



 Score = 29.3 bits (64), Expect = 8.8
 Identities = 16/58 (27%), Positives = 31/58 (53%), Gaps = 4/58 (6%)

Query: 378 VKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMD 435
           V+ + A N+  ++  E    +++FYAPWC  C+  + ++ E   K  +   I + K+D
Sbjct: 39  VQPMTASNWTLVMEGE---WMLKFYAPWCPSCQQTDSEW-EAFAKNGEILQISVGKVD 92


>gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo
           sapiens]
          Length = 258

 Score = 37.0 bits (84), Expect = 0.042
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 7/71 (9%)

Query: 49  LVEFFAPWCGHCKRLAPEYEAAATRLKGI-VPLAKVDCTANTNTCNKYGVS------GYP 101
           +VEFFA W   C+  AP Y   + +     +   KVD    T+   +Y VS        P
Sbjct: 121 IVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLP 180

Query: 102 TLKIFRDGEEA 112
           TL +F+ G+EA
Sbjct: 181 TLILFQGGKEA 191



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 9/88 (10%)

Query: 387 DEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMD-ATANDVPSPY 445
           +E+  ++    ++EF+A W   C++  P Y +L  K +    +   K+D     DV + Y
Sbjct: 110 EELERDKRVTWIVEFFANWSNDCQSFAPIYADLSLKYN-CTGLNFGKVDVGRYTDVSTRY 168

Query: 446 EVRGFPTIYFSPANKKLNPK-KYEGGRE 472
           +V        SP  K+L     ++GG+E
Sbjct: 169 KVS------TSPLTKQLPTLILFQGGKE 190


>gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo
           sapiens]
          Length = 296

 Score = 37.0 bits (84), Expect = 0.042
 Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 7/71 (9%)

Query: 49  LVEFFAPWCGHCKRLAPEYEAAATRLKGI-VPLAKVDCTANTNTCNKYGVS------GYP 101
           +VEFFA W   C+  AP Y   + +     +   KVD    T+   +Y VS        P
Sbjct: 159 IVEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLP 218

Query: 102 TLKIFRDGEEA 112
           TL +F+ G+EA
Sbjct: 219 TLILFQGGKEA 229



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 9/88 (10%)

Query: 387 DEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMD-ATANDVPSPY 445
           +E+  ++    ++EF+A W   C++  P Y +L  K +    +   K+D     DV + Y
Sbjct: 148 EELERDKRVTWIVEFFANWSNDCQSFAPIYADLSLKYN-CTGLNFGKVDVGRYTDVSTRY 206

Query: 446 EVRGFPTIYFSPANKKLNPK-KYEGGRE 472
           +V        SP  K+L     ++GG+E
Sbjct: 207 KVS------TSPLTKQLPTLILFQGGKE 228


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,937,335
Number of Sequences: 37866
Number of extensions: 867613
Number of successful extensions: 2124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1970
Number of HSP's gapped (non-prelim): 112
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.