Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 113722125

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa
precursor [Homo sapiens]
         (913 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs...  1862   0.0  
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso...   787   0.0  
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso...   784   0.0  
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                  211   2e-54
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                  211   2e-54
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                  211   2e-54
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                  211   3e-54
gi|26190608 synaptojanin 2 [Homo sapiens]                             206   6e-53
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas...   186   1e-46
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho...   179   1e-44
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H...   165   2e-40
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho...   165   2e-40
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap...   161   3e-39
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ...   152   1e-36
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ...   152   1e-36
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]     127   5e-29
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa...    74   6e-13
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa...    74   6e-13
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    74   6e-13
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             69   2e-11
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap...    63   1e-09
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi...    63   1e-09
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]                59   2e-08
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi...    59   2e-08
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi...    59   2e-08
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a...    57   6e-08
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b...    57   6e-08
gi|56119110 family with sequence similarity 13, member A1 isofor...    56   2e-07
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ...    54   7e-07
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ...    54   7e-07

>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
           [Homo sapiens]
          Length = 913

 Score = 1862 bits (4823), Expect = 0.0
 Identities = 913/913 (100%), Positives = 913/913 (100%)

Query: 1   MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM 60
           MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM
Sbjct: 1   MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM 60

Query: 61  AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM 120
           AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM
Sbjct: 61  AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM 120

Query: 121 FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGS 180
           FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGS
Sbjct: 121 FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGGS 180

Query: 181 NFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQK 240
           NFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQK
Sbjct: 181 NFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQK 240

Query: 241 FGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVG 300
           FGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVG
Sbjct: 241 FGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVG 300

Query: 301 FQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAY 360
           FQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAY
Sbjct: 301 FQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAY 360

Query: 361 ISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICS 420
           ISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICS
Sbjct: 361 ISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICS 420

Query: 421 RMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKI 480
           RMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKI
Sbjct: 421 RMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKI 480

Query: 481 QVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQS 540
           QVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQS
Sbjct: 481 QVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQS 540

Query: 541 HMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQ 600
           HMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQ
Sbjct: 541 HMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQ 600

Query: 601 NVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLEL 660
           NVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLEL
Sbjct: 601 NVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLEL 660

Query: 661 FVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILD 720
           FVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILD
Sbjct: 661 FVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILD 720

Query: 721 LPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEF 780
           LPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEF
Sbjct: 721 LPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEF 780

Query: 781 EHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVI 840
           EHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVI
Sbjct: 781 EHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVI 840

Query: 841 STLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKK 900
           STLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKK
Sbjct: 841 STLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKK 900

Query: 901 AQEFIHQFLCNPL 913
           AQEFIHQFLCNPL
Sbjct: 901 AQEFIHQFLCNPL 913


>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
           isoform b [Homo sapiens]
          Length = 893

 Score =  787 bits (2033), Expect = 0.0
 Identities = 387/748 (51%), Positives = 528/748 (70%), Gaps = 32/748 (4%)

Query: 184 GLRPNGKGVPMDQSSRGQDKPESLQ--------------PRQ----NKSKSEITDMVRSS 225
           G   N   + +D+    Q++P  +               PR+    NK + ++T+ +R  
Sbjct: 150 GFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMR-- 207

Query: 226 TITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRL 285
                 K  + + Q  G R+ ++K  L ++E++Y  IQ FRFF GT+NVNGQSP   L  
Sbjct: 208 ------KLFVPNTQS-GQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEP 260

Query: 286 WLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLV 345
           WL+     PD+YC+GFQELDLS EAFF+ ++ KE+EW  AV  GLH  AKY KV+L+RLV
Sbjct: 261 WLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLV 320

Query: 346 GIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHI 405
           G+MLL++ +++   YI ++  ETVGTGIMG+MGNKGGVA+RF FHNT+ C+VNSHLAAH+
Sbjct: 321 GMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHV 380

Query: 406 EEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIE 465
           E++ERRNQDYKDIC+RM F  P+ +LP L I  H+V++WLGDLNYR+   D  +VK LI 
Sbjct: 381 EDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLIN 440

Query: 466 EKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDR 525
           +KD Q L  +DQL IQ   K  F  F EGE+ F PTYKYD+ +D WD+S KCR PAWCDR
Sbjct: 441 KKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDR 500

Query: 526 ILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENA 585
           ILW+G N+ QL+Y+SHM LKTSDHKPVS++F IGV+VV++  YRK  E+ VR +D+MEN 
Sbjct: 501 ILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMEND 560

Query: 586 NIPSVSLSKREFCFQNVKYMQLKVESFTI-HNGQVPCHFEFINKPDEESYCKQWLNANPS 644
            +PS+ LS+REF F+NVK+ QL+ E F I +NGQVPCHF FI K ++  YCK WL A P 
Sbjct: 561 FLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPF 620

Query: 645 RGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCF 704
            G+L P+  V+I L+++V+K + T LNSGEDKIEDILVLHLDRGKDYFL++SGNYLPSCF
Sbjct: 621 EGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCF 680

Query: 705 GSPIHTLCYMREPILDLPLETISEL--TLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYR 762
           G+ +  LC M+ PI ++P+  + +L  +L+ +   D+G+  + P+++PKE+W++VD+L++
Sbjct: 681 GTSLEALCRMKRPIREVPVTKLIDLEKSLLQMVPLDEGAS-ERPLQVPKEIWLLVDHLFK 739

Query: 763 NAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYST 822
            A  QEDLFQ PG++ E + I DCLDT + + +  SNHSVAEALL+FLE+LPEPVICY  
Sbjct: 740 YACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYEL 799

Query: 823 YHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSL 882
           Y  CL+ + +    +QVIS LP  H+NVF YLMAFLRELLK S  N ++ N++A++F SL
Sbjct: 800 YQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSL 859

Query: 883 LLRNPAG-HQKLDMTEKKKAQEFIHQFL 909
           LLR P     +   +++++A +F+  FL
Sbjct: 860 LLRPPPNLMARQTPSDRQRAIQFLLGFL 887


>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
           isoform a [Homo sapiens]
          Length = 901

 Score =  784 bits (2025), Expect = 0.0
 Identities = 387/756 (51%), Positives = 528/756 (69%), Gaps = 40/756 (5%)

Query: 184 GLRPNGKGVPMDQSSRGQDKPESLQ--------------PRQ----NKSKSEITDMVRSS 225
           G   N   + +D+    Q++P  +               PR+    NK + ++T+ +R  
Sbjct: 150 GFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMR-- 207

Query: 226 TITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRL 285
                 K  + + Q  G R+ ++K  L ++E++Y  IQ FRFF GT+NVNGQSP   L  
Sbjct: 208 ------KLFVPNTQS-GQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEP 260

Query: 286 WLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLV 345
           WL+     PD+YC+GFQELDLS EAFF+ ++ KE+EW  AV  GLH  AKY KV+L+RLV
Sbjct: 261 WLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLV 320

Query: 346 GIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHI 405
           G+MLL++ +++   YI ++  ETVGTGIMG+MGNKGGVA+RF FHNT+ C+VNSHLAAH+
Sbjct: 321 GMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHV 380

Query: 406 EEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIE 465
           E++ERRNQDYKDIC+RM F  P+ +LP L I  H+V++WLGDLNYR+   D  +VK LI 
Sbjct: 381 EDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLIN 440

Query: 466 EKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDR 525
           +KD Q L  +DQL IQ   K  F  F EGE+ F PTYKYD+ +D WD+S KCR PAWCDR
Sbjct: 441 KKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDR 500

Query: 526 ILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENA 585
           ILW+G N+ QL+Y+SHM LKTSDHKPVS++F IGV+VV++  YRK  E+ VR +D+MEN 
Sbjct: 501 ILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMEND 560

Query: 586 NIPSVSLSKREFCFQNVKYMQLKVESFTI-HNGQVPCHFEFINKPDEESYCKQWLNANPS 644
            +PS+ LS+REF F+NVK+ QL+ E F I +NGQVPCHF FI K ++  YCK WL A P 
Sbjct: 561 FLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPF 620

Query: 645 RGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCF 704
            G+L P+  V+I L+++V+K + T LNSGEDKIEDILVLHLDRGKDYFL++SGNYLPSCF
Sbjct: 621 EGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCF 680

Query: 705 GSPIHTLCYMREPILDLPLETISEL----------TLMPVWTGDDGSQLDSPMEIPKELW 754
           G+ +  LC M+ PI ++P+  + +L          +L+ +   D+G+  + P+++PKE+W
Sbjct: 681 GTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGAS-ERPLQVPKEIW 739

Query: 755 MMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLP 814
           ++VD+L++ A  QEDLFQ PG++ E + I DCLDT + + +  SNHSVAEALL+FLE+LP
Sbjct: 740 LLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALP 799

Query: 815 EPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENI 874
           EPVICY  Y  CL+ + +    +QVIS LP  H+NVF YLMAFLRELLK S  N ++ N+
Sbjct: 800 EPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANM 859

Query: 875 LASIFGSLLLRNPAG-HQKLDMTEKKKAQEFIHQFL 909
           +A++F SLLLR P     +   +++++A +F+  FL
Sbjct: 860 IATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFL 895


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/416 (33%), Positives = 214/416 (51%), Gaps = 63/416 (15%)

Query: 212 NKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGT 271
           N   S++ D  R+   T S +    ++Q    +  ++KS + +    Y+  +  R   GT
Sbjct: 483 NTLNSDLADKARALLTTGSLRVSEQTLQSASSK--VLKS-MCENFYKYSKPKKIRVCVGT 539

Query: 272 YNVNGQSP-------KECLRLWLSN-----GIQA--------PDVYCVGFQEL-DLSKEA 310
           +NVNG           + L  WL +     GIQ          D++ +GF+E+ +L+   
Sbjct: 540 WNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 599

Query: 311 FFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG 370
                T  ++ W   + + +  D KY  +   +LVG+ L ++++ +HA +I +V  +TV 
Sbjct: 600 IVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVK 659

Query: 371 TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPS 430
           TG+ G  GNKG VAIR  FH TS+C V SH AA   + + RN+D+ +I  ++ F      
Sbjct: 660 TGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSF------ 713

Query: 431 LPPL--TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVF 488
             P+   + +HD + W GD NYRI+ L  E+VK+LI ++++  L A DQL  Q  A  VF
Sbjct: 714 --PMGRMLFSHDYVFWCGDFNYRID-LPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVF 770

Query: 489 EGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-----------NITQLS 537
            GF EG++TF PTYKYD  SDD+DTSEKCR PAW DR+LW+ +           ++   S
Sbjct: 771 RGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS 830

Query: 538 YQ-----------------SHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 576
           +Q                     LKTSDH+PV ++ DI +  V  E  +   +E++
Sbjct: 831 FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI 886


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/416 (33%), Positives = 214/416 (51%), Gaps = 63/416 (15%)

Query: 212 NKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGT 271
           N   S++ D  R+   T S +    ++Q    +  ++KS + +    Y+  +  R   GT
Sbjct: 522 NTLNSDLADKARALLTTGSLRVSEQTLQSASSK--VLKS-MCENFYKYSKPKKIRVCVGT 578

Query: 272 YNVNGQSP-------KECLRLWLSN-----GIQA--------PDVYCVGFQEL-DLSKEA 310
           +NVNG           + L  WL +     GIQ          D++ +GF+E+ +L+   
Sbjct: 579 WNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 638

Query: 311 FFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG 370
                T  ++ W   + + +  D KY  +   +LVG+ L ++++ +HA +I +V  +TV 
Sbjct: 639 IVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVK 698

Query: 371 TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPS 430
           TG+ G  GNKG VAIR  FH TS+C V SH AA   + + RN+D+ +I  ++ F      
Sbjct: 699 TGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSF------ 752

Query: 431 LPPL--TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVF 488
             P+   + +HD + W GD NYRI+ L  E+VK+LI ++++  L A DQL  Q  A  VF
Sbjct: 753 --PMGRMLFSHDYVFWCGDFNYRID-LPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVF 809

Query: 489 EGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-----------NITQLS 537
            GF EG++TF PTYKYD  SDD+DTSEKCR PAW DR+LW+ +           ++   S
Sbjct: 810 RGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS 869

Query: 538 YQ-----------------SHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 576
           +Q                     LKTSDH+PV ++ DI +  V  E  +   +E++
Sbjct: 870 FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI 925


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score =  211 bits (538), Expect = 2e-54
 Identities = 138/416 (33%), Positives = 214/416 (51%), Gaps = 63/416 (15%)

Query: 212 NKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGT 271
           N   S++ D  R+   T S +    ++Q    +  ++KS + +    Y+  +  R   GT
Sbjct: 522 NTLNSDLADKARALLTTGSLRVSEQTLQSASSK--VLKS-MCENFYKYSKPKKIRVCVGT 578

Query: 272 YNVNGQSP-------KECLRLWLSN-----GIQA--------PDVYCVGFQEL-DLSKEA 310
           +NVNG           + L  WL +     GIQ          D++ +GF+E+ +L+   
Sbjct: 579 WNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 638

Query: 311 FFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG 370
                T  ++ W   + + +  D KY  +   +LVG+ L ++++ +HA +I +V  +TV 
Sbjct: 639 IVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVK 698

Query: 371 TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPS 430
           TG+ G  GNKG VAIR  FH TS+C V SH AA   + + RN+D+ +I  ++ F      
Sbjct: 699 TGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSF------ 752

Query: 431 LPPL--TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVF 488
             P+   + +HD + W GD NYRI+ L  E+VK+LI ++++  L A DQL  Q  A  VF
Sbjct: 753 --PMGRMLFSHDYVFWCGDFNYRID-LPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVF 809

Query: 489 EGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-----------NITQLS 537
            GF EG++TF PTYKYD  SDD+DTSEKCR PAW DR+LW+ +           ++   S
Sbjct: 810 RGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS 869

Query: 538 YQ-----------------SHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 576
           +Q                     LKTSDH+PV ++ DI +  V  E  +   +E++
Sbjct: 870 FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI 925


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score =  211 bits (536), Expect = 3e-54
 Identities = 139/420 (33%), Positives = 213/420 (50%), Gaps = 65/420 (15%)

Query: 212 NKSKSEITDMVRSSTITVSDKAH----ILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRF 267
           + SK E  D++       SD A     +L+         ++KS + +    Y+  +  R 
Sbjct: 472 DSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRASSKVLKS-MCENFYKYSKPKKIRV 530

Query: 268 FAGTYNVNGQSP-------KECLRLWLSN-----GIQA--------PDVYCVGFQEL-DL 306
             GT+NVNG           + L  WL +     GIQ          D++ +GF+E+ +L
Sbjct: 531 CVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVEL 590

Query: 307 SKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEA 366
           +        T  ++ W   + + +  D KY  +   +LVG+ L ++++ +HA +I +V  
Sbjct: 591 NAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAV 650

Query: 367 ETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQ 426
           +TV TG+ G  GNKG VAIR  FH TS+C V SH AA   + + RN+D+ +I  ++ F  
Sbjct: 651 DTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSF-- 708

Query: 427 PDPSLPPL--TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAA 484
                 P+   + +HD + W GD NYRI+ L  E+VK+LI ++++  L A DQL  Q  A
Sbjct: 709 ------PMGRMLFSHDYVFWCGDFNYRID-LPNEEVKELIRQQNWDSLIAGDQLINQKNA 761

Query: 485 KTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-----------NI 533
             VF GF EG++TF PTYKYD  SDD+DTSEKCR PAW DR+LW+ +           ++
Sbjct: 762 GQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDL 821

Query: 534 TQLSYQ-----------------SHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 576
              S+Q                     LKTSDH+PV ++ DI +  V  E  +   +E++
Sbjct: 822 LNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI 881


>gi|26190608 synaptojanin 2 [Homo sapiens]
          Length = 1496

 Score =  206 bits (525), Expect = 6e-53
 Identities = 133/423 (31%), Positives = 212/423 (50%), Gaps = 63/423 (14%)

Query: 229 VSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNG--QSPKECLRL- 285
           V+DK  +L      L    +   + +++ ++T  +  R   GT+NVNG  Q     LR  
Sbjct: 494 VADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTA 553

Query: 286 ----WLSNGIQAP------------DVYCVGFQEL-DLSKEAFFFHDTPKEEEWFKAVSE 328
               WL +  Q              D++ VGF+E+ +LS        T  ++ W + + +
Sbjct: 554 ELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQK 613

Query: 329 GLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQ 388
            +    +Y  +   +LVG+ L ++V+  H  +I +V  +TV TG+ G+ GNKG V IRFQ
Sbjct: 614 AISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQ 673

Query: 389 FHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL--TISNHDVILWLG 446
           FH+TS C + SHL A   + + RN+DYK+I  ++ F        P+   + +HD + W G
Sbjct: 674 FHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCF--------PMGRNVFSHDYVFWCG 725

Query: 447 DLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDT 506
           D NYRI +L  E+V   ++ +D++ L  +DQL++Q ++  +F+ F EG + F PTYKYD 
Sbjct: 726 DFNYRI-DLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDV 784

Query: 507 GSDDWDTSEKCRAPAWCDRILWKGK-----------NITQ-----------------LSY 538
           GS  +DTS+KCR PAW DR+LW  K           N+                   L Y
Sbjct: 785 GSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQY 844

Query: 539 QSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVR---SLDKMENANIPSVSL-SK 594
                L+ SDH+PV ++ ++ V+ V+     +  +E+      LD     N+ S +L  K
Sbjct: 845 YGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPTLEEK 904

Query: 595 REF 597
            EF
Sbjct: 905 NEF 907


>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
           A [Homo sapiens]
          Length = 638

 Score =  186 bits (471), Expect = 1e-46
 Identities = 107/308 (34%), Positives = 161/308 (52%), Gaps = 30/308 (9%)

Query: 271 TYNVNGQSPKE----CLRLWLSNGIQAPDVYCVGFQELD--LSKEAFFFHDTPKEEEWFK 324
           T+NV    P +     L L   +     D+  +G QE++  L+K      D    ++W +
Sbjct: 61  TWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKR---LKDALFTDQWSE 117

Query: 325 AVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVA 384
              + L P   +  V  +R+ G++LLL+ K  H  ++ +V+ +   TG+ G  GNKGGV+
Sbjct: 118 LFMDALGP-FNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVS 176

Query: 385 IRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILW 444
           +R       +C +N HL AH+++ E+R  +++ I S  QF  P        I +HD++ W
Sbjct: 177 VRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQ----GILDHDLVFW 232

Query: 445 LGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKY 504
            GDLN+RIE  D+  VK  I+      L+  DQL +      + +GF EG L F PT+K+
Sbjct: 233 FGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKF 292

Query: 505 DTGSDDWDTSEKCRAPAWCDRILWKGK----------------NITQLSYQSHMALKTSD 548
           D G++ +DTS K R PAW DRILWK K                 +TQ SY+SHM    SD
Sbjct: 293 DVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSD 352

Query: 549 HKPVSSVF 556
           HKPV++ F
Sbjct: 353 HKPVAAQF 360


>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
           sapiens]
          Length = 448

 Score =  179 bits (453), Expect = 1e-44
 Identities = 109/310 (35%), Positives = 163/310 (52%), Gaps = 25/310 (8%)

Query: 271 TYNVNGQSPKECLR--LWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSE 328
           T+NV   +P   L   L L+N     D+Y +G QEL+ S       D    + W   + +
Sbjct: 20  TWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELN-SGIISLLSDAAFNDSWSSFLMD 78

Query: 329 GLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQ 388
            L P   + KV  +R+ GI+LL++ K +H  YI  +  ++  TG+ G  GNKGGV I  +
Sbjct: 79  VLSP-LSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLK 137

Query: 389 FHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDL 448
            +   + ++N HL  HI    +R + +  I   MQ C+    +P   I +HD+I+W GD+
Sbjct: 138 LYGYYVSIINCHLPPHISNNYQRLEHFDRILE-MQNCE-GRDIP--NILDHDLIIWFGDM 193

Query: 449 NYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGS 508
           N+RIE+  +  V++ I+ + +  L+  DQL I      +   F EG L F PTYK+D  S
Sbjct: 194 NFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNS 253

Query: 509 DDWDTSEKCRAPAWCDRILWKGK-----------------NITQLSYQSHMALKTSDHKP 551
           +D+DTSEK R PAW DRILW+ K                 +++   Y SHM    SDHKP
Sbjct: 254 NDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKP 313

Query: 552 VSSVFDIGVR 561
           VS  FD+ ++
Sbjct: 314 VSGTFDLELK 323


>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  165 bits (418), Expect = 2e-40
 Identities = 90/243 (37%), Positives = 135/243 (55%), Gaps = 21/243 (8%)

Query: 336 YAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSIC 395
           + KV  +R+ GI+LL++ K +H  YI  +  ++  TG+ G  GNKGGV I  + +   + 
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 396 VVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEEL 455
           ++N HL  HI    +R + +  I   MQ C+    +P   I +HD+I+W GD+N+RIE+ 
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILE-MQNCE-GRDIP--NILDHDLIIWFGDMNFRIEDF 124

Query: 456 DVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSE 515
            +  V++ I+ + +  L+  DQL I      +   F EG L F PTYK+D  S+D+DTSE
Sbjct: 125 GLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSE 184

Query: 516 KCRAPAWCDRILWKGK-----------------NITQLSYQSHMALKTSDHKPVSSVFDI 558
           K R PAW DRILW+ K                 +++   Y SHM    SDHKPVS  FD+
Sbjct: 185 KKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDL 244

Query: 559 GVR 561
            ++
Sbjct: 245 ELK 247


>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  165 bits (418), Expect = 2e-40
 Identities = 90/243 (37%), Positives = 135/243 (55%), Gaps = 21/243 (8%)

Query: 336 YAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSIC 395
           + KV  +R+ GI+LL++ K +H  YI  +  ++  TG+ G  GNKGGV I  + +   + 
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 396 VVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEEL 455
           ++N HL  HI    +R + +  I   MQ C+    +P   I +HD+I+W GD+N+RIE+ 
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILE-MQNCE-GRDIP--NILDHDLIIWFGDMNFRIEDF 124

Query: 456 DVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSE 515
            +  V++ I+ + +  L+  DQL I      +   F EG L F PTYK+D  S+D+DTSE
Sbjct: 125 GLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSE 184

Query: 516 KCRAPAWCDRILWKGK-----------------NITQLSYQSHMALKTSDHKPVSSVFDI 558
           K R PAW DRILW+ K                 +++   Y SHM    SDHKPVS  FD+
Sbjct: 185 KKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDL 244

Query: 559 GVR 561
            ++
Sbjct: 245 ELK 247


>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
           sapiens]
          Length = 1258

 Score =  161 bits (407), Expect = 3e-39
 Identities = 111/334 (33%), Positives = 158/334 (47%), Gaps = 43/334 (12%)

Query: 251 HLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNG----------IQAP-DVYCV 299
           H  Q E D   +     F GT+N+    P + +  W ++           +  P D+Y  
Sbjct: 415 HSKQDEPDMISV-----FIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVF 469

Query: 300 GFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP--DAKYAKVKLIRLVGIMLLLYVKQEH 357
           G QE  +            + EW   +  GL    D  Y  + +  L  I + + VK EH
Sbjct: 470 GTQENSVG-----------DREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEH 518

Query: 358 AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKD 417
              IS V   +V TGI   +GNKG V + F F+ TS   VN HL +  E+  RRNQ+Y D
Sbjct: 519 ENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLD 578

Query: 418 ICSRMQFCQPDPSLPPLTIS-NHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYD 476
           I   +     D  L    IS     + W GDLNYR+ ++D++++   I  K+F+ L   D
Sbjct: 579 ILRLLSL--GDRQLNAFDISLRFTHLFWFGDLNYRL-DMDIQEILNYISRKEFEPLLRVD 635

Query: 477 QLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDD---W----DTSEKCRAPAWCDRILWK 529
           QL ++     VF  F+E E++F PTY+Y+ GS D   W     T  +   P+WCDRILWK
Sbjct: 636 QLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK 695

Query: 530 GKNITQL---SYQSHMALKTSDHKPVSSVFDIGV 560
               T +   SY     + TSDH PV   F++GV
Sbjct: 696 SYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGV 729


>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
           sapiens]
          Length = 1188

 Score =  152 bits (385), Expect = 1e-36
 Identities = 106/336 (31%), Positives = 160/336 (47%), Gaps = 44/336 (13%)

Query: 251 HLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAP-----------DVYCV 299
           H  Q E D   I     F GT+N+    P + +  W  +  Q             D+Y +
Sbjct: 394 HSEQPEPDMITI-----FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVI 448

Query: 300 GFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP--DAKYAKVKLIRLVGIMLLLYVKQEH 357
           G QE  LS           E+EW + +   L       +  V +  L  I +++  K EH
Sbjct: 449 GTQEDPLS-----------EKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEH 497

Query: 358 AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKD 417
              IS +  + V TGI   +GNKG V + F F+ TS+  VNSHL +  E+  RRNQ+Y +
Sbjct: 498 ENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMN 557

Query: 418 ICSRMQFCQPDPSLPPLTISNHDV-ILWLGDLNYRIE--ELDVEKVKKLIEEKDFQMLYA 474
           I   +     D  L P  I++    + W GDLNYR++    + E + + I+++ +  L +
Sbjct: 558 ILRFLAL--GDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLS 615

Query: 475 YDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDD-------WDTSEKCRAPAWCDRIL 527
           +DQL  +   + VF  F E E+TF PTY+++  + D         T  K   P+WCDR+L
Sbjct: 616 HDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVL 675

Query: 528 WKGKNITQL---SYQSHMALKTSDHKPVSSVFDIGV 560
           WK   +  +   SY S   + TSDH PV + F+ GV
Sbjct: 676 WKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 711


>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
           sapiens]
          Length = 1189

 Score =  152 bits (385), Expect = 1e-36
 Identities = 106/336 (31%), Positives = 160/336 (47%), Gaps = 44/336 (13%)

Query: 251 HLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAP-----------DVYCV 299
           H  Q E D   I     F GT+N+    P + +  W  +  Q             D+Y +
Sbjct: 395 HSEQPEPDMITI-----FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVI 449

Query: 300 GFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP--DAKYAKVKLIRLVGIMLLLYVKQEH 357
           G QE  LS           E+EW + +   L       +  V +  L  I +++  K EH
Sbjct: 450 GTQEDPLS-----------EKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEH 498

Query: 358 AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKD 417
              IS +  + V TGI   +GNKG V + F F+ TS+  VNSHL +  E+  RRNQ+Y +
Sbjct: 499 ENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMN 558

Query: 418 ICSRMQFCQPDPSLPPLTISNHDV-ILWLGDLNYRIE--ELDVEKVKKLIEEKDFQMLYA 474
           I   +     D  L P  I++    + W GDLNYR++    + E + + I+++ +  L +
Sbjct: 559 ILRFLAL--GDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLS 616

Query: 475 YDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDD-------WDTSEKCRAPAWCDRIL 527
           +DQL  +   + VF  F E E+TF PTY+++  + D         T  K   P+WCDR+L
Sbjct: 617 HDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVL 676

Query: 528 WKGKNITQL---SYQSHMALKTSDHKPVSSVFDIGV 560
           WK   +  +   SY S   + TSDH PV + F+ GV
Sbjct: 677 WKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 712


>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
          Length = 644

 Score =  127 bits (319), Expect = 5e-29
 Identities = 91/321 (28%), Positives = 148/321 (46%), Gaps = 31/321 (9%)

Query: 263 QNFRFFAGTYNVNGQS---PKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKE 319
           +N   F  T+N+ GQ    P     L  +    A D+Y +G QE                
Sbjct: 297 RNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQE-----------GCSDR 345

Query: 320 EEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGN 379
            EW   + E L P   Y  +       + + L+++++   + SEVE  TV T I+ ++  
Sbjct: 346 REWETRLQETLGPH--YVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKT 403

Query: 380 KGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNH 439
           KG + I F F  TS   + SH  +   +   R  DY      +   +  P   P   S  
Sbjct: 404 KGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAA 463

Query: 440 DV------ILWLGDLNYRIEE----LDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFE 489
           DV      + W GD N+R+      +D    + L+   D   L  +DQL  ++   ++F+
Sbjct: 464 DVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVV--DVPALLQHDQLIREMRKGSIFK 521

Query: 490 GFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK---NITQLSYQSHMALKT 546
           GF E ++ F P+YK+D G D +D++ K R P++ DR+L++ +   +I  +SY S   +KT
Sbjct: 522 GFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKT 581

Query: 547 SDHKPVSSVFDIGVRVVNDEL 567
           SDH+PV  +F + VR   D +
Sbjct: 582 SDHRPVYGLFRVKVRPGRDNI 602


>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
           sapiens]
          Length = 653

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 45/140 (32%), Positives = 75/140 (53%), Gaps = 12/140 (8%)

Query: 757 VDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASN--HSVAEALLLFLESLP 814
           VD++ +  +++E LF+ PG  +  + ++D  D G   +  ++   H+VA  L L+L  LP
Sbjct: 65  VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 124

Query: 815 EPVICYSTYHNCLEC---------SGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNS 865
           EPVI Y+ Y + L C         +G    +KQV  +LP+ + N+  Y+  FL E+   S
Sbjct: 125 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQV-KSLPVVNYNLLKYICRFLDEVQSYS 183

Query: 866 AKNHLDENILASIFGSLLLR 885
             N +    LA++FG  +LR
Sbjct: 184 GVNKMSVQNLATVFGPNILR 203


>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
           sapiens]
          Length = 655

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 45/140 (32%), Positives = 75/140 (53%), Gaps = 12/140 (8%)

Query: 757 VDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASN--HSVAEALLLFLESLP 814
           VD++ +  +++E LF+ PG  +  + ++D  D G   +  ++   H+VA  L L+L  LP
Sbjct: 67  VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 126

Query: 815 EPVICYSTYHNCLEC---------SGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNS 865
           EPVI Y+ Y + L C         +G    +KQV  +LP+ + N+  Y+  FL E+   S
Sbjct: 127 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQV-KSLPVVNYNLLKYICRFLDEVQSYS 185

Query: 866 AKNHLDENILASIFGSLLLR 885
             N +    LA++FG  +LR
Sbjct: 186 GVNKMSVQNLATVFGPNILR 205


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 45/140 (32%), Positives = 75/140 (53%), Gaps = 12/140 (8%)

Query: 757 VDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASN--HSVAEALLLFLESLP 814
           VD++ +  +++E LF+ PG  +  + ++D  D G   +  ++   H+VA  L L+L  LP
Sbjct: 160 VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 219

Query: 815 EPVICYSTYHNCLEC---------SGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNS 865
           EPVI Y+ Y + L C         +G    +KQV  +LP+ + N+  Y+  FL E+   S
Sbjct: 220 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQV-KSLPVVNYNLLKYICRFLDEVQSYS 278

Query: 866 AKNHLDENILASIFGSLLLR 885
             N +    LA++FG  +LR
Sbjct: 279 GVNKMSVQNLATVFGPNILR 298


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 46/151 (30%), Positives = 74/151 (49%), Gaps = 12/151 (7%)

Query: 746 PMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGM--IDNLSASNHSVA 803
           P   P  +   VD++    + +E LF+ PG  +    ++D  D G   + + +   H+VA
Sbjct: 169 PRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVA 228

Query: 804 EALLLFLESLPEPVICYSTYHNCLECS---------GNYTASKQVISTLPIFHKNVFHYL 854
             L L+L  LPEPV+ ++ Y + L C+         G    +KQV S LP  + N+  Y+
Sbjct: 229 SLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQV-SNLPQANYNLLRYI 287

Query: 855 MAFLRELLKNSAKNHLDENILASIFGSLLLR 885
             FL E+   S  N +    LA++FG  +LR
Sbjct: 288 CKFLDEVQAYSNVNKMSVQNLATVFGPNILR 318


>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
           sapiens]
          Length = 645

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 41/151 (27%), Positives = 72/151 (47%), Gaps = 10/151 (6%)

Query: 746 PMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASN--HSVA 803
           P  +P  +    +++  +   +E +F+ PG  +  + +RD  D G   +       H+VA
Sbjct: 173 PHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVA 232

Query: 804 EALLLFLESLPEPVICYSTYHNCLECSGNYTASK--------QVISTLPIFHKNVFHYLM 855
             L L+L  LPEPV+ +S Y   L C     A +        + +S LP  + ++  Y+ 
Sbjct: 233 SLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYIC 292

Query: 856 AFLRELLKNSAKNHLDENILASIFGSLLLRN 886
            FL E+  N A N +  + LA++ G  L+R+
Sbjct: 293 RFLHEIQLNCAVNKMSVDNLATVIGVNLIRS 323


>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
           sapiens]
          Length = 638

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 41/151 (27%), Positives = 72/151 (47%), Gaps = 10/151 (6%)

Query: 746 PMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASN--HSVA 803
           P  +P  +    +++  +   +E +F+ PG  +  + +RD  D G   +       H+VA
Sbjct: 166 PHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVA 225

Query: 804 EALLLFLESLPEPVICYSTYHNCLECSGNYTASK--------QVISTLPIFHKNVFHYLM 855
             L L+L  LPEPV+ +S Y   L C     A +        + +S LP  + ++  Y+ 
Sbjct: 226 SLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYIC 285

Query: 856 AFLRELLKNSAKNHLDENILASIFGSLLLRN 886
            FL E+  N A N +  + LA++ G  L+R+
Sbjct: 286 RFLHEIQLNCAVNKMSVDNLATVIGVNLIRS 316


>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
          Length = 555

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 7/143 (4%)

Query: 749 IPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLS--ASNHSVAEAL 806
           IP  L   V YL    ++ E LF++         I+   + G   N       H  A  L
Sbjct: 331 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 390

Query: 807 LLFLESLPEPVICYSTYHN-----CLECSGNYTASKQVISTLPIFHKNVFHYLMAFLREL 861
             FL  LP+P++ +  Y       C+E S   T  +Q++ +LP  +  V  YLM FL  +
Sbjct: 391 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 450

Query: 862 LKNSAKNHLDENILASIFGSLLL 884
            + S  N ++ + LA +FG  L+
Sbjct: 451 SRESIFNKMNSSNLACVFGLNLI 473


>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
           sapiens]
          Length = 433

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 7/143 (4%)

Query: 749 IPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLS--ASNHSVAEAL 806
           IP  L   V YL    ++ E LF++         I+   + G   N       H  A  L
Sbjct: 209 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 268

Query: 807 LLFLESLPEPVICYSTYHN-----CLECSGNYTASKQVISTLPIFHKNVFHYLMAFLREL 861
             FL  LP+P++ +  Y       C+E S   T  +Q++ +LP  +  V  YLM FL  +
Sbjct: 269 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 328

Query: 862 LKNSAKNHLDENILASIFGSLLL 884
            + S  N ++ + LA +FG  L+
Sbjct: 329 SRESIFNKMNSSNLACVFGLNLI 351


>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
           sapiens]
          Length = 464

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 7/143 (4%)

Query: 749 IPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLS--ASNHSVAEAL 806
           IP  L   V YL    ++ E LF++         I+   + G   N       H  A  L
Sbjct: 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 299

Query: 807 LLFLESLPEPVICYSTYHN-----CLECSGNYTASKQVISTLPIFHKNVFHYLMAFLREL 861
             FL  LP+P++ +  Y       C+E S   T  +Q++ +LP  +  V  YLM FL  +
Sbjct: 300 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 359

Query: 862 LKNSAKNHLDENILASIFGSLLL 884
            + S  N ++ + LA +FG  L+
Sbjct: 360 SRESIFNKMNSSNLACVFGLNLI 382


>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
           [Homo sapiens]
          Length = 1071

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 42/161 (26%), Positives = 72/161 (44%), Gaps = 12/161 (7%)

Query: 744 DSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNH--- 800
           DS   IP  +   + ++ R+ +Q E +F+  G + E   I++  + G  D L+   +   
Sbjct: 499 DSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGE-DPLAGDQNDHD 557

Query: 801 --SVAEALLLFLESLPEPVICYSTYHNCLEC------SGNYTASKQVISTLPIFHKNVFH 852
             S+A  L L+   L  P+     +H+ + C             ++V+  LP     +  
Sbjct: 558 MDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMR 617

Query: 853 YLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKL 893
           YL AFL  L + S +N +D   LA  FG  L+  P GH ++
Sbjct: 618 YLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQV 658


>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
           [Homo sapiens]
          Length = 836

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 42/161 (26%), Positives = 72/161 (44%), Gaps = 12/161 (7%)

Query: 744 DSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNH--- 800
           DS   IP  +   + ++ R+ +Q E +F+  G + E   I++  + G  D L+   +   
Sbjct: 499 DSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGE-DPLAGDQNDHD 557

Query: 801 --SVAEALLLFLESLPEPVICYSTYHNCLEC------SGNYTASKQVISTLPIFHKNVFH 852
             S+A  L L+   L  P+     +H+ + C             ++V+  LP     +  
Sbjct: 558 MDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMR 617

Query: 853 YLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKL 893
           YL AFL  L + S +N +D   LA  FG  L+  P GH ++
Sbjct: 618 YLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQV 658


>gi|56119110 family with sequence similarity 13, member A1 isoform a
           [Homo sapiens]
          Length = 1023

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 40/149 (26%), Positives = 71/149 (47%), Gaps = 8/149 (5%)

Query: 749 IPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNH--SVAEAL 806
           IP  +W +V+YL ++ + QE LF+  G     E +R   ++G+   L       S A  L
Sbjct: 58  IPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLL 117

Query: 807 LLFLESLPEPVICYSTYHNCLECSGN------YTASKQVISTLPIFHKNVFHYLMAFLRE 860
            LFL  LP+ +I  +     ++   +       ++ + +I  LP  H  +  YL  FL +
Sbjct: 118 KLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTK 177

Query: 861 LLKNSAKNHLDENILASIFGSLLLRNPAG 889
           + K+  +N ++ + LA++FG      P G
Sbjct: 178 VAKHHVQNRMNVHNLATVFGPNCFHVPPG 206


>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
           [Homo sapiens]
          Length = 1075

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 10/156 (6%)

Query: 744 DSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTG---MIDNLSASN- 799
           DS   IP  +   + Y+    +QQ+ +F+ PG + E   I++  + G   ++D+ +  + 
Sbjct: 490 DSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDI 549

Query: 800 HSVAEALLLFLESLPEPVICYSTYHNCLEC------SGNYTASKQVISTLPIFHKNVFHY 853
           +SVA  L L+   L  P+     + + +        +      +Q++ TLP     V  Y
Sbjct: 550 NSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRY 609

Query: 854 LMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAG 889
           L AFL  L + S +N +D   LA  FG  L+  P G
Sbjct: 610 LFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDG 645


>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
           [Homo sapiens]
          Length = 1099

 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 42/156 (26%), Positives = 72/156 (46%), Gaps = 10/156 (6%)

Query: 744 DSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTG---MIDNLSASN- 799
           DS   IP  +   + Y+    +QQ+ +F+ PG + E   I++  + G   ++D+ +  + 
Sbjct: 514 DSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDI 573

Query: 800 HSVAEALLLFLESLPEPVICYSTYHNCLEC------SGNYTASKQVISTLPIFHKNVFHY 853
           +SVA  L L+   L  P+     + + +        +      +Q++ TLP     V  Y
Sbjct: 574 NSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRY 633

Query: 854 LMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAG 889
           L AFL  L + S +N +D   LA  FG  L+  P G
Sbjct: 634 LFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDG 669


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,516,996
Number of Sequences: 37866
Number of extensions: 1661240
Number of successful extensions: 4131
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 54
Number of HSP's that attempted gapping in prelim test: 3957
Number of HSP's gapped (non-prelim): 132
length of query: 913
length of database: 18,247,518
effective HSP length: 111
effective length of query: 802
effective length of database: 14,044,392
effective search space: 11263602384
effective search space used: 11263602384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press