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Search of human proteins with 21361553
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
(635 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 1310 0.0
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 1248 0.0
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 691 0.0
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 383 e-106
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 213 6e-55
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 213 6e-55
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 206 7e-53
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 206 7e-53
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 205 1e-52
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 205 1e-52
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 204 3e-52
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 204 3e-52
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 204 3e-52
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 204 3e-52
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 204 3e-52
gi|29725609 epidermal growth factor receptor isoform a precursor... 203 3e-52
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 196 5e-50
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|4503787 fyn-related kinase [Homo sapiens] 195 9e-50
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 193 5e-49
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 193 5e-49
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 192 8e-49
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 191 1e-48
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 191 1e-48
gi|54792098 erbB-2 isoform b [Homo sapiens] 191 2e-48
gi|54792096 erbB-2 isoform a [Homo sapiens] 191 2e-48
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 191 2e-48
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 191 2e-48
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 1310 bits (3389), Expect = 0.0
Identities = 635/635 (100%), Positives = 635/635 (100%)
Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300
Query: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
Sbjct: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360
Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
Sbjct: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420
Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
Sbjct: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480
Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540
Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600
Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 1248 bits (3229), Expect = 0.0
Identities = 612/635 (96%), Positives = 612/635 (96%), Gaps = 23/635 (3%)
Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA
Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------------------ 282
Query: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360
SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
Sbjct: 283 -----SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 337
Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
Sbjct: 338 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 397
Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
Sbjct: 398 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 457
Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
Sbjct: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517
Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
Sbjct: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577
Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Sbjct: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 691 bits (1782), Expect = 0.0
Identities = 342/631 (54%), Positives = 451/631 (71%), Gaps = 30/631 (4%)
Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65
M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+
Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125
IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++
Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185
++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G
Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245
++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+
Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
Query: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305
KADGL+ L C + N + P LP +HP+T +
Sbjct: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPSTLT-------------------- 278
Query: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 365
R+ T++ + Y PE A + P+ +PMDT VYESPY+DPEE++ K+++L
Sbjct: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFL 332
Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425
R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M
Sbjct: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391
Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKY 484
QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R + N+ EL+HQVSMGMKY
Sbjct: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451
Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544
LEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI
Sbjct: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511
Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604
N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L
Sbjct: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571
Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
M+ CW Y E+RP F VE R+R YY + +
Sbjct: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 383 bits (983), Expect = e-106
Identities = 183/296 (61%), Positives = 232/296 (78%), Gaps = 2/296 (0%)
Query: 341 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 400
+PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA
Sbjct: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
Query: 401 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 460
+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L
Sbjct: 61 IKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL 119
Query: 461 QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519
R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL
Sbjct: 120 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 179
Query: 520 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579
AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG
Sbjct: 180 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239
Query: 580 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + +
Sbjct: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 295
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 213 bits (541), Expect = 6e-55
Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%)
Query: 344 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 402
+ + Y P EI+ + + L R + G G FG V +G Y + VA+K
Sbjct: 425 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 476
Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462
KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ
Sbjct: 477 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 535
Query: 463 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521
++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ +
Sbjct: 536 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 594
Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581
D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V
Sbjct: 595 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 653
Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626
+E GER+ P CP +Y LM CW YD RP F ++ +L
Sbjct: 654 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 698
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 213 bits (541), Expect = 6e-55
Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%)
Query: 344 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 402
+ + Y P EI+ + + L R + G G FG V +G Y + VA+K
Sbjct: 403 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 454
Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462
KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ
Sbjct: 455 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 513
Query: 463 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521
++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ +
Sbjct: 514 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 572
Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581
D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V
Sbjct: 573 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 631
Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626
+E GER+ P CP +Y LM CW YD RP F ++ +L
Sbjct: 632 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 676
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 206 bits (523), Expect = 7e-53
Identities = 109/261 (41%), Positives = 163/261 (62%), Gaps = 11/261 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V +G + KK TVAVK LK + + +E L EA VM
Sbjct: 237 MERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 290
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S
Sbjct: 291 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 350
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 351 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 408
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++
Sbjct: 409 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 468
Query: 602 YDLMNLCWTYDVENRPGFAAV 622
Y+LM CW ++ +RP FA +
Sbjct: 469 YELMRACWQWNPSDRPSFAEI 489
Score = 78.6 bits (192), Expect = 2e-14
Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 123 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GKL + +F+TL +LV H+S ADGL+ L P K
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 219
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 127 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 184
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121
++ + A+L H+HS +DGL+ L P N+P GV P +E
Sbjct: 185 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 236
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 206 bits (523), Expect = 7e-53
Identities = 109/261 (41%), Positives = 163/261 (62%), Gaps = 11/261 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V +G + KK TVAVK LK + + +E L EA VM
Sbjct: 256 MERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 309
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S
Sbjct: 310 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 369
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 370 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 427
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++
Sbjct: 428 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 487
Query: 602 YDLMNLCWTYDVENRPGFAAV 622
Y+LM CW ++ +RP FA +
Sbjct: 488 YELMRACWQWNPSDRPSFAEI 508
Score = 78.6 bits (192), Expect = 2e-14
Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 142 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GKL + +F+TL +LV H+S ADGL+ L P K
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 238
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 146 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121
++ + A+L H+HS +DGL+ L P N+P GV P +E
Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 205 bits (521), Expect = 1e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
Query: 612 DVENRPGF 619
D ++RP F
Sbjct: 960 DADSRPKF 967
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 205 bits (521), Expect = 1e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
Query: 612 DVENRPGF 619
D ++RP F
Sbjct: 960 DADSRPKF 967
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 204 bits (518), Expect = 3e-52
Identities = 111/271 (40%), Positives = 162/271 (59%), Gaps = 11/271 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM
Sbjct: 268 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 321
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 439
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499
Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632
Y+LM CW + +RP FA ++D
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETMFHD 530
Score = 76.6 bits (187), Expect = 6e-14
Identities = 40/99 (40%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GK+ + +F TL +LV H+S ADGL+ L P K
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 250
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 204 bits (518), Expect = 3e-52
Identities = 111/271 (40%), Positives = 162/271 (59%), Gaps = 11/271 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM
Sbjct: 283 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 336
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S
Sbjct: 337 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 396
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 397 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 454
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514
Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632
Y+LM CW + +RP FA ++D
Sbjct: 515 YELMRACWKWSPADRPSFAETHQAFETMFHD 545
Score = 76.6 bits (187), Expect = 6e-14
Identities = 40/99 (40%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 169 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GK+ + +F TL +LV H+S ADGL+ L P K
Sbjct: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 265
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 173 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 230
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 276
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 204 bits (518), Expect = 3e-52
Identities = 111/271 (40%), Positives = 162/271 (59%), Gaps = 11/271 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM
Sbjct: 262 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 315
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S
Sbjct: 316 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 375
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 376 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 433
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++
Sbjct: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493
Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632
Y+LM CW + +RP FA ++D
Sbjct: 494 YELMRACWKWSPADRPSFAETHQAFETMFHD 524
Score = 76.6 bits (187), Expect = 6e-14
Identities = 40/99 (40%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 148 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GK+ + +F TL +LV H+S ADGL+ L P K
Sbjct: 206 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 244
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 152 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 209
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 210 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 255
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 204 bits (518), Expect = 3e-52
Identities = 111/271 (40%), Positives = 162/271 (59%), Gaps = 11/271 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM
Sbjct: 268 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 321
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S
Sbjct: 322 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 381
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 382 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 439
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499
Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632
Y+LM CW + +RP FA ++D
Sbjct: 500 YELMRACWKWSPADRPSFAETHQAFETMFHD 530
Score = 76.6 bits (187), Expect = 6e-14
Identities = 40/99 (40%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GK+ + +F TL +LV H+S ADGL+ L P K
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 250
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 204 bits (518), Expect = 3e-52
Identities = 111/271 (40%), Positives = 162/271 (59%), Gaps = 11/271 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM
Sbjct: 247 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV---EEFLKEAAVM 300
Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMG 481
+++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S
Sbjct: 301 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 360
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541
M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP
Sbjct: 361 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 418
Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601
E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++
Sbjct: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478
Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632
Y+LM CW + +RP FA ++D
Sbjct: 479 YELMRACWKWSPADRPSFAETHQAFETMFHD 509
Score = 76.6 bits (187), Expect = 6e-14
Identities = 40/99 (40%), Positives = 59/99 (59%), Gaps = 3/99 (3%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 133 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261
GK+ + +F TL +LV H+S ADGL+ L P K
Sbjct: 191 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPK 229
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 137 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 194
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 195 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 203 bits (517), Expect = 3e-52
Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%)
Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++
Sbjct: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 774
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V
Sbjct: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++
Sbjct: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 893
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
+SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW
Sbjct: 894 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 953
Query: 612 DVENRPGF 619
D ++RP F
Sbjct: 954 DADSRPKF 961
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 377 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 494
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 615 NRPGFAAVELRLRNYY 630
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 377 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 494
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 615 NRPGFAAVELRLRNYY 630
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 377 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 494
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 615 NRPGFAAVELRLRNYY 630
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 377 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 494
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 615 NRPGFAAVELRLRNYY 630
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 195 bits (496), Expect = 9e-50
Identities = 106/270 (39%), Positives = 164/270 (60%), Gaps = 11/270 (4%)
Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424
+DR + L K LGSG FG V +G + VAVK LK + DP ++ L EA +M
Sbjct: 229 IDRNSIQLL-KRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGSMDP---NDFLREAQIM 281
Query: 425 QQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSMG 481
+ L +P ++++ +C E + ++ E+ G L +YLQ + K +++ QV+ G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD-ENYYKAQTHGKWPVKWYA 540
M YLE N++HRDLAARNVL+ + K++DFGL++ + D E+ Y+++ K PVKW A
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600
PE I KFS KSDVWSFG+L++E +YG+ PY GM G++V ML + R+ P+ CP++
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630
Y++M CW + + RP F + +L +Y+
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGK 225
PWF G I R ++E+ +L G FLIR ++ G ++L +L V HYRI + G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 226 LSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKI 262
+ + F TL + V HY+ +DGL L PC KI
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKI 211
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/93 (34%), Positives = 50/93 (53%)
Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73
P+FFG I R +AE L+ G +L+R+S + G F+LSV G HY I+R G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106
+ + R ++ + ++++ SDGL L KP
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKP 207
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 193 bits (490), Expect = 5e-49
Identities = 115/302 (38%), Positives = 171/302 (56%), Gaps = 17/302 (5%)
Query: 331 AADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY 390
A+D R + P T+ + P+ + E P+E KL+ + LG+G FG V GYY
Sbjct: 212 ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETL---KLV----ERLGAGQFGEVWMGYY 264
Query: 391 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEM 450
VAVK LK + P D LAEAN+M+QL + +VR+ + E ++ E
Sbjct: 265 NGHT---KVAVKSLKQGSMSP---DAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEY 318
Query: 451 AELGPLNKYLQQNRHVK--DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508
E G L +L+ +K ++++ Q++ GM ++EE N++HRDL A N+L+
Sbjct: 319 MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 378
Query: 509 KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY 568
KI+DFGL++ + ++N Y A+ K+P+KW APE INY F+ KSDVWSFG+L+ E ++
Sbjct: 379 KIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTH 436
Query: 569 GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628
G+ PY GM EV LE+G RM P CP E+Y LM LCW E+RP F + L +
Sbjct: 437 GRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496
Query: 629 YY 630
++
Sbjct: 497 FF 498
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 6/103 (5%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLL----HEGKVL-HYR 217
E PWF +SR+++E+ +L T+G FLIR ++ GS++L + ++G+V+ HY+
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ 260
I G I F L +LV HY+ +DGL L+ PCQ
Sbjct: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ 225
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%)
Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61
A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115
HY I NG + I+ T +L +++ SDGL L +P + +P
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 193 bits (490), Expect = 5e-49
Identities = 115/302 (38%), Positives = 171/302 (56%), Gaps = 17/302 (5%)
Query: 331 AADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY 390
A+D R + P T+ + P+ + E P+E KL+ + LG+G FG V GYY
Sbjct: 212 ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETL---KLV----ERLGAGQFGEVWMGYY 264
Query: 391 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEM 450
VAVK LK + P D LAEAN+M+QL + +VR+ + E ++ E
Sbjct: 265 NGHT---KVAVKSLKQGSMSP---DAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEY 318
Query: 451 AELGPLNKYLQQNRHVK--DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508
E G L +L+ +K ++++ Q++ GM ++EE N++HRDL A N+L+
Sbjct: 319 MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 378
Query: 509 KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY 568
KI+DFGL++ + ++N Y A+ K+P+KW APE INY F+ KSDVWSFG+L+ E ++
Sbjct: 379 KIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTH 436
Query: 569 GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628
G+ PY GM EV LE+G RM P CP E+Y LM LCW E+RP F + L +
Sbjct: 437 GRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496
Query: 629 YY 630
++
Sbjct: 497 FF 498
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/103 (35%), Positives = 58/103 (56%), Gaps = 6/103 (5%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLL----HEGKVL-HYR 217
E PWF +SR+++E+ +L T+G FLIR ++ GS++L + ++G+V+ HY+
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ 260
I G I F L +LV HY+ +DGL L+ PCQ
Sbjct: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ 225
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%)
Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61
A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115
HY I NG + I+ T +L +++ SDGL L +P + +P
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 192 bits (488), Expect = 8e-49
Identities = 112/305 (36%), Positives = 176/305 (57%), Gaps = 10/305 (3%)
Query: 323 YEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNF 382
Y +L ++ +G + +D YE P E +R +D + +E+ +G+G F
Sbjct: 575 YSDKLQHYSTGRGSPGMKIYIDPFTYEDPN---EAVREFAKEIDVSFVKIEEV-IGAGEF 630
Query: 383 GTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-E 440
G V KG ++ K VA+K LK ++ +D L+EA++M Q D+P I+R+ G+ +
Sbjct: 631 GEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD-FLSEASIMGQFDHPNIIRLEGVVTK 689
Query: 441 AESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 499
+ M++ E E G L+ +L+QN ++ ++ ++ GMKYL E N+VHRDLAARN
Sbjct: 690 SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARN 749
Query: 500 VLLVTQHYAKISDFGLSKALRADEN--YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWS 557
+L+ + K+SDFGLS+ L+ D + Y + GK PV+W APE I Y KF+S SDVWS
Sbjct: 750 ILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809
Query: 558 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617
+G++MWE S+G++PY M +V +E+ R+ P CP ++ LM CW D +RP
Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869
Query: 618 GFAAV 622
FA +
Sbjct: 870 RFAEI 874
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 191 bits (486), Expect = 1e-48
Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%)
Query: 375 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 432
++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ +
Sbjct: 130 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 189
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
+R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+
Sbjct: 190 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 249
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS
Sbjct: 250 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 309
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 610
SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW
Sbjct: 310 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 369
Query: 611 YDVENRPGFAAV 622
+ E+RP F A+
Sbjct: 370 HKPEDRPTFVAL 381
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 191 bits (486), Expect = 1e-48
Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%)
Query: 375 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 432
++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ +
Sbjct: 193 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 252
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
+R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+
Sbjct: 253 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 312
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS
Sbjct: 313 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 372
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 610
SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW
Sbjct: 373 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 432
Query: 611 YDVENRPGFAAV 622
+ E+RP F A+
Sbjct: 433 HKPEDRPTFVAL 444
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 191 bits (485), Expect = 2e-48
Identities = 105/248 (42%), Positives = 153/248 (61%), Gaps = 5/248 (2%)
Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+
Sbjct: 694 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 752
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V
Sbjct: 753 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 812
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+
Sbjct: 813 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG-GKVPIKWMALESILRRRFTH 871
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 872 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 931
Query: 612 DVENRPGF 619
D E RP F
Sbjct: 932 DSECRPRF 939
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 191 bits (485), Expect = 2e-48
Identities = 105/248 (42%), Positives = 153/248 (61%), Gaps = 5/248 (2%)
Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432
K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+
Sbjct: 724 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 782
Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491
R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V
Sbjct: 783 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 842
Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+
Sbjct: 843 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG-GKVPIKWMALESILRRRFTH 901
Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 902 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 961
Query: 612 DVENRPGF 619
D E RP F
Sbjct: 962 DSECRPRF 969
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 191 bits (485), Expect = 2e-48
Identities = 102/252 (40%), Positives = 151/252 (59%), Gaps = 8/252 (3%)
Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436
LG GNFG V KG + K +VAVK K + LK + L EA +++Q D+P IV++I
Sbjct: 569 LGKGNFGEVYKGTLKDKT---SVAVKTCKEDLPQE-LKIKFLQEAKILKQYDHPNIVKLI 624
Query: 437 GIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRD 494
G+C + + ++ME+ G +L++ + +K K +++ + GM YLE N +HRD
Sbjct: 625 GVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRD 684
Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554
LAARN L+ + KISDFG+S+ + D Y + + P+KW APE +NY ++SS+SD
Sbjct: 685 LAARNCLVGENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESD 742
Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614
VWSFG+L+WE FS G PY GM + +E+G RM P CP ++ +M CW Y E
Sbjct: 743 VWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPE 802
Query: 615 NRPGFAAVELRL 626
NRP F+ ++ L
Sbjct: 803 NRPKFSELQKEL 814
Score = 40.0 bits (92), Expect = 0.007
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 18/127 (14%)
Query: 120 FEDLKENLIREYVKQTWNLQGQALEQAI-ISQKPQLEKLIATTAHEKMPWFHGKISREES 178
FE ++ ++ L AL I IS+KP E+ W+HG I R E+
Sbjct: 421 FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQ----------DWYHGAIPRIEA 470
Query: 179 EQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTL 237
++++ K G FL+R + G Y L + +G+ H+ I + EG F +
Sbjct: 471 QELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII--QYVDNMYRFEGTGFSNI 524
Query: 238 WQLVEHY 244
QL++H+
Sbjct: 525 PQLIDHH 531
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 191 bits (484), Expect = 2e-48
Identities = 104/269 (38%), Positives = 160/269 (59%), Gaps = 10/269 (3%)
Query: 366 DRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421
D+ +L ED +++G GNFG V G + + VAVK + E P LK + L EA
Sbjct: 424 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTL--VAVKSCR-ETLPPDLKAKFLQEA 480
Query: 422 NVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVS 479
+++Q +P IVR+IG+C + + +VME+ + G +L+ + ++ K ++++V +
Sbjct: 481 RILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAA 540
Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539
GM+YLE +HRDLAARN L+ ++ KISDFG+S+ AD Y + + PVKW
Sbjct: 541 AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWT 599
Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599
APE +NY ++SS+SDVWSFG+L+WE FS G PY + + +EKG R+ CP CP
Sbjct: 600 APEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPD 659
Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLRN 628
++ LM CW Y+ RP F+ + L++
Sbjct: 660 AVFRLMEQCWAYEPGQRPSFSTIYQELQS 688
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,561,586
Number of Sequences: 37866
Number of extensions: 1245739
Number of successful extensions: 4776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 644
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 2888
Number of HSP's gapped (non-prelim): 1137
length of query: 635
length of database: 18,247,518
effective HSP length: 109
effective length of query: 526
effective length of database: 14,120,124
effective search space: 7427185224
effective search space used: 7427185224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.