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Search of human proteins with 21361101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361101 MAP kinase-interacting serine/threonine kinase 1
isoform 1 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361101 MAP kinase-interacting serine/threonine kinase 1 iso... 938 0.0
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is... 837 0.0
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso... 666 0.0
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso... 582 e-166
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso... 530 e-151
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 169 4e-42
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 169 4e-42
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 169 4e-42
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 169 4e-42
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 168 1e-41
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 168 1e-41
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 163 3e-40
gi|4758700 mitogen-activated protein kinase-activated protein ki... 161 1e-39
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 160 2e-39
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 158 9e-39
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 153 3e-37
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 153 3e-37
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 152 5e-37
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom... 152 5e-37
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom... 152 5e-37
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 152 5e-37
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 151 1e-36
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 151 1e-36
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 151 1e-36
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 151 1e-36
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 151 1e-36
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 151 1e-36
gi|32481209 mitogen-activated protein kinase-activated protein k... 150 2e-36
gi|10863901 mitogen-activated protein kinase-activated protein k... 150 2e-36
gi|27901803 protein serine kinase H1 [Homo sapiens] 150 2e-36
>gi|21361101 MAP kinase-interacting serine/threonine kinase 1
isoform 1 [Homo sapiens]
Length = 465
Score = 938 bits (2425), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180
Query: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
Sbjct: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240
Query: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
Sbjct: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300
Query: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
Sbjct: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360
Query: 361 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 420
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
Sbjct: 361 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 420
Query: 421 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 465
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
Sbjct: 421 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 465
>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
Length = 424
Score = 837 bits (2161), Expect = 0.0
Identities = 424/465 (91%), Positives = 424/465 (91%), Gaps = 41/465 (8%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK---------------- 164
Query: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240
GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
Sbjct: 165 -------------------------GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 199
Query: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
Sbjct: 200 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 259
Query: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
Sbjct: 260 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 319
Query: 361 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 420
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
Sbjct: 320 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 379
Query: 421 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 465
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
Sbjct: 380 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 424
>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
isoform 2 [Homo sapiens]
Length = 347
Score = 666 bits (1719), Expect = 0.0
Identities = 336/382 (87%), Positives = 337/382 (88%), Gaps = 41/382 (10%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK---------------- 164
Query: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240
GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
Sbjct: 165 -------------------------GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 199
Query: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
Sbjct: 200 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 259
Query: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
Sbjct: 260 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 319
Query: 361 QRLSAAQVLQHPWVQGQAPEKG 382
QRLSAAQVLQHPWVQG+ G
Sbjct: 320 QRLSAAQVLQHPWVQGEQQHNG 341
>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
Length = 465
Score = 582 bits (1499), Expect = e-166
Identities = 295/448 (65%), Positives = 343/448 (76%), Gaps = 51/448 (11%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
Query: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGS 191
IL+HI K++HFNE EAS VV+DVA+ALDFLH K
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNK--------------------------- 199
Query: 192 SDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTP 251
GIAHRDLKPENILCE P +VSPVKICDFDLGSG+KLN C+PI+TP
Sbjct: 200 --------------GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 252 ELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGW 311
EL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LYI+LSGYPPFVG CG+DCGW
Sbjct: 246 ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGW 305
Query: 312 DRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 371
DRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLISKLLVRDAKQRLSAAQVLQH
Sbjct: 306 DRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQH 365
Query: 372 PWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEA----- 426
PWVQG APE LPTP VLQRNS DLT FAAEAIA+NRQL+QH+E +LAEE A
Sbjct: 366 PWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDE-DLAEEEAAGQGQP 424
Query: 427 ---LADGLCSMKLSPPCKSRLARRRALA 451
A C ++LSPP +S+LA+RR A
Sbjct: 425 VLVRATSRC-LQLSPPSQSKLAQRRQRA 451
>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
isoform 1 [Homo sapiens]
Length = 414
Score = 530 bits (1366), Expect = e-151
Identities = 259/380 (68%), Positives = 298/380 (78%), Gaps = 41/380 (10%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
Query: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGS 191
IL+HI K++HFNE EAS VV+DVA+ALDFLH K
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNK--------------------------- 199
Query: 192 SDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTP 251
GIAHRDLKPENILCE P +VSPVKICDFDLGSG+KLN C+PI+TP
Sbjct: 200 --------------GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTP 245
Query: 252 ELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGW 311
EL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LYI+LSGYPPFVG CG+DCGW
Sbjct: 246 ELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGW 305
Query: 312 DRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 371
DRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLISKLLVRDAKQRLSAAQVLQH
Sbjct: 306 DRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQH 365
Query: 372 PWVQGQAPEKGLPTPQVLQR 391
PWVQG APE LPTP VLQR
Sbjct: 366 PWVQGCAPENTLPTPMVLQR 385
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 169 bits (429), Expect = 4e-42
Identities = 131/407 (32%), Positives = 192/407 (47%), Gaps = 79/407 (19%)
Query: 23 DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
DG R + L GK F D Y + E +G G+Y++ + V EYAVK+
Sbjct: 399 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 457
Query: 80 IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
I+K S+ E+E L + + NI+ L + ++D YLV E ++GG +L I +Q
Sbjct: 458 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 513
Query: 140 KHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSAS 199
K F+EREAS V+ + +++LH++
Sbjct: 514 KFFSEREASFVLHTIGKTVEYLHSQ----------------------------------- 538
Query: 200 QVAGTTGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPC 257
G+ HRDLKP NIL E +P ++ICDF ++ N L TPC
Sbjct: 539 ------GVVHRDLKPSNILYVD-ESGNPECLRICDFGFAKQLRAENGL-------LMTPC 584
Query: 258 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 317
+A ++APEV++ YD+ CD+WSLG++LY ML+GY PF A+ D E
Sbjct: 585 YTANFVAPEVLK-----RQGYDEGCDIWSLGILLYTMLAGYTPF-----ANGPSDTPE-- 632
Query: 318 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--Q 375
++ I GK+ +W +S AKDL+SK+L D QRL+A QVLQHPWV +
Sbjct: 633 -----EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 687
Query: 376 GQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAE 422
+ P+ L + Q LQ M T A + QL E + LA+
Sbjct: 688 DKLPQSQL-SHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQ 733
Score = 82.4 bits (202), Expect = 8e-16
Identities = 79/317 (24%), Positives = 130/317 (41%), Gaps = 79/317 (24%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG+G++ KV + +G YA+K+++K R RV ++E N +
Sbjct: 75 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 134
Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVS 168
+ + F+ + + YL+ + L+GG + + K+ F E + + ++A LD LH+
Sbjct: 135 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS----- 189
Query: 169 LCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPV 228
GI +RDLKPENIL + +
Sbjct: 190 ------------------------------------LGIIYRDLKPENILLDEE---GHI 210
Query: 229 KICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLG 288
K+ DF L + + + CG+ EYMAPEVV + D WS G
Sbjct: 211 KLTDFGLSKEAIDHEK-------KAYSFCGTVEYMAPEVVN-----RQGHSHSADWWSYG 258
Query: 289 VVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAK 348
V+++ ML+G PF G DR E + I + K P +S+EA+
Sbjct: 259 VLMFEMLTGSLPFQGK-------DRKETMTL--------ILKAKLGMPQ----FLSTEAQ 299
Query: 349 DLISKLLVRDAKQRLSA 365
L+ L R+ RL +
Sbjct: 300 SLLRALFKRNPANRLGS 316
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 169 bits (429), Expect = 4e-42
Identities = 131/407 (32%), Positives = 192/407 (47%), Gaps = 79/407 (19%)
Query: 23 DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
DG R + L GK F D Y + E +G G+Y++ + V EYAVK+
Sbjct: 390 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 448
Query: 80 IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
I+K S+ E+E L + + NI+ L + ++D YLV E ++GG +L I +Q
Sbjct: 449 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 504
Query: 140 KHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSAS 199
K F+EREAS V+ + +++LH++
Sbjct: 505 KFFSEREASFVLHTIGKTVEYLHSQ----------------------------------- 529
Query: 200 QVAGTTGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPC 257
G+ HRDLKP NIL E +P ++ICDF ++ N L TPC
Sbjct: 530 ------GVVHRDLKPSNILYVD-ESGNPECLRICDFGFAKQLRAENGL-------LMTPC 575
Query: 258 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 317
+A ++APEV++ YD+ CD+WSLG++LY ML+GY PF A+ D E
Sbjct: 576 YTANFVAPEVLK-----RQGYDEGCDIWSLGILLYTMLAGYTPF-----ANGPSDTPE-- 623
Query: 318 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--Q 375
++ I GK+ +W +S AKDL+SK+L D QRL+A QVLQHPWV +
Sbjct: 624 -----EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 678
Query: 376 GQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAE 422
+ P+ L + Q LQ M T A + QL E + LA+
Sbjct: 679 DKLPQSQL-SHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQ 724
Score = 82.4 bits (202), Expect = 8e-16
Identities = 79/317 (24%), Positives = 130/317 (41%), Gaps = 79/317 (24%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG+G++ KV + +G YA+K+++K R RV ++E N +
Sbjct: 66 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 125
Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVS 168
+ + F+ + + YL+ + L+GG + + K+ F E + + ++A LD LH+
Sbjct: 126 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS----- 180
Query: 169 LCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPV 228
GI +RDLKPENIL + +
Sbjct: 181 ------------------------------------LGIIYRDLKPENILLDEE---GHI 201
Query: 229 KICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLG 288
K+ DF L + + + CG+ EYMAPEVV + D WS G
Sbjct: 202 KLTDFGLSKEAIDHEK-------KAYSFCGTVEYMAPEVVN-----RQGHSHSADWWSYG 249
Query: 289 VVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAK 348
V+++ ML+G PF G DR E + I + K P +S+EA+
Sbjct: 250 VLMFEMLTGSLPFQGK-------DRKETMTL--------ILKAKLGMPQ----FLSTEAQ 290
Query: 349 DLISKLLVRDAKQRLSA 365
L+ L R+ RL +
Sbjct: 291 SLLRALFKRNPANRLGS 307
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 169 bits (429), Expect = 4e-42
Identities = 130/409 (31%), Positives = 190/409 (46%), Gaps = 96/409 (23%)
Query: 44 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
F D Y++ ++ G G+Y+ + V EYAVKII+K S+ E+E L +
Sbjct: 419 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 473
Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
+ NI+ L + ++D YLV E ++GG +L I +Q++F+EREAS V+ + +D+LH+
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533
Query: 164 KDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPE 223
+ G+ HRDLKP NIL E
Sbjct: 534 Q-----------------------------------------GVVHRDLKPSNILYRD-E 551
Query: 224 KVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 281
SP +++CDF ++ N L TPC +A ++APEV++ YD
Sbjct: 552 SGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANFVAPEVLK-----RQGYDAA 599
Query: 282 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 341
CD+WSLG++LY ML+G+ PF G D D E ++ I GKY +W
Sbjct: 600 CDIWSLGILLYTMLAGFTPFAN--GPD---DTPE-------EILARIGSGKYALSGGNWD 647
Query: 342 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF 401
IS AKD++SK+L D QRL+A QVL+HPWV + +P L R +
Sbjct: 648 SISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNREYLSPNQLSRQDVHLVKGAM 703
Query: 402 AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRAL 450
AA ALNR P+A +L P S LA+RR +
Sbjct: 704 AATYFALNR------------TPQA-------PRLEPVLSSNLAQRRGM 733
Score = 89.4 bits (220), Expect = 6e-18
Identities = 88/342 (25%), Positives = 143/342 (41%), Gaps = 89/342 (26%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G+Y KV + G+ YA+K+++K R RV ++E
Sbjct: 64 PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 157 ALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPEN 216
ALD LH+ GI +RDLKPEN
Sbjct: 179 ALDHLHS-----------------------------------------LGIIYRDLKPEN 197
Query: 217 ILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQAT 276
IL + +KI DF L ++ + CG+ EYMAPEVV
Sbjct: 198 ILLDEE---GHIKITDFGLSKEAIDHDK-------RAYSFCGTIEYMAPEVVN-----RR 242
Query: 277 FYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFP 336
+ + D WS GV+++ ML+G PF G DR E + I + K P
Sbjct: 243 GHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETMAL--------ILKAKLGMP 287
Query: 337 DKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPW 373
+S EA+ L+ L R+ RL A ++ +HP+
Sbjct: 288 Q----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 325
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 169 bits (429), Expect = 4e-42
Identities = 130/409 (31%), Positives = 190/409 (46%), Gaps = 96/409 (23%)
Query: 44 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
F D Y++ ++ G G+Y+ + V EYAVKII+K S+ E+E L +
Sbjct: 411 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 465
Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
+ NI+ L + ++D YLV E ++GG +L I +Q++F+EREAS V+ + +D+LH+
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
Query: 164 KDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPE 223
+ G+ HRDLKP NIL E
Sbjct: 526 Q-----------------------------------------GVVHRDLKPSNILYRD-E 543
Query: 224 KVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 281
SP +++CDF ++ N L TPC +A ++APEV++ YD
Sbjct: 544 SGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANFVAPEVLK-----RQGYDAA 591
Query: 282 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 341
CD+WSLG++LY ML+G+ PF G D D E ++ I GKY +W
Sbjct: 592 CDIWSLGILLYTMLAGFTPFAN--GPD---DTPE-------EILARIGSGKYALSGGNWD 639
Query: 342 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF 401
IS AKD++SK+L D QRL+A QVL+HPWV + +P L R +
Sbjct: 640 SISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNREYLSPNQLSRQDVHLVKGAM 695
Query: 402 AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRAL 450
AA ALNR P+A +L P S LA+RR +
Sbjct: 696 AATYFALNR------------TPQA-------PRLEPVLSSNLAQRRGM 725
Score = 89.4 bits (220), Expect = 6e-18
Identities = 88/342 (25%), Positives = 143/342 (41%), Gaps = 89/342 (26%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G+Y KV + G+ YA+K+++K R RV ++E
Sbjct: 56 PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 110
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 157 ALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPEN 216
ALD LH+ GI +RDLKPEN
Sbjct: 171 ALDHLHS-----------------------------------------LGIIYRDLKPEN 189
Query: 217 ILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQAT 276
IL + +KI DF L ++ + CG+ EYMAPEVV
Sbjct: 190 ILLDEE---GHIKITDFGLSKEAIDHDK-------RAYSFCGTIEYMAPEVVN-----RR 234
Query: 277 FYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFP 336
+ + D WS GV+++ ML+G PF G DR E + I + K P
Sbjct: 235 GHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETMAL--------ILKAKLGMP 279
Query: 337 DKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPW 373
+S EA+ L+ L R+ RL A ++ +HP+
Sbjct: 280 Q----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 317
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 168 bits (425), Expect = 1e-41
Identities = 115/363 (31%), Positives = 175/363 (48%), Gaps = 65/363 (17%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L LG+G+++ + Q+G+E+AVKI+ ++ + REV L CQ + N++
Sbjct: 406 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 462
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSL 169
L E D YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H +
Sbjct: 463 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEE----- 517
Query: 170 CHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVK 229
G+ HRDLKPENIL +PVK
Sbjct: 518 -----------------------------------AGVVHRDLKPENILYADDTPGAPVK 542
Query: 230 ICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGV 289
I DF ++ + P + TPC + +Y APE++ YD+ CDLWSLGV
Sbjct: 543 IIDFGFAR-LRPQSPGVP-----MQTPCFTLQYAAPELLA-----QQGYDESCDLWSLGV 591
Query: 290 VLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKD 349
+LY+MLSG PF G G E+ +C+ I+EG++ + W +S EAK+
Sbjct: 592 ILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IREGRFSLDGEAWQGVSEEAKE 643
Query: 350 LISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP--TPQVLQRNSSTMDLTLFAAEAIA 407
L+ LL D +RL + W+Q + P TP VL+ + + L A +A
Sbjct: 644 LVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGL-NATFMA 702
Query: 408 LNR 410
NR
Sbjct: 703 FNR 705
Score = 94.7 bits (234), Expect = 2e-19
Identities = 89/342 (26%), Positives = 142/342 (41%), Gaps = 93/342 (27%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG GAY KV + A GK YA+K++ K A R++ T +++LE
Sbjct: 37 KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90
Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
L+ F+ D + +L+ + + GG + H+ ++++F E E ++ AL+
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILC 219
LH GI +RDLK EN+L
Sbjct: 151 HLHK-----------------------------------------LGIIYRDLKLENVLL 169
Query: 220 ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD 279
+S + + DF L + CG+ EYMAPE++ T +
Sbjct: 170 DSE---GHIVLTDFGLSKEFLTEEKERTFSF------CGTIEYMAPEIIR----SKTGHG 216
Query: 280 KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD 339
K D WSLG++L+ +L+G PF GE R Q ++ I + FP +
Sbjct: 217 KAVDWWSLGILLFELLTGASPFT---------LEGE--RNTQAEVSRRILKCSPPFPPR- 264
Query: 340 WAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 376
I A+DL+ +LL +D K+RL A +V HP+ QG
Sbjct: 265 ---IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQG 303
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 168 bits (425), Expect = 1e-41
Identities = 115/363 (31%), Positives = 175/363 (48%), Gaps = 65/363 (17%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L LG+G+++ + Q+G+E+AVKI+ ++ + REV L CQ + N++
Sbjct: 412 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 468
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSL 169
L E D YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H +
Sbjct: 469 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEE----- 523
Query: 170 CHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVK 229
G+ HRDLKPENIL +PVK
Sbjct: 524 -----------------------------------AGVVHRDLKPENILYADDTPGAPVK 548
Query: 230 ICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGV 289
I DF ++ + P + TPC + +Y APE++ YD+ CDLWSLGV
Sbjct: 549 IIDFGFAR-LRPQSPGVP-----MQTPCFTLQYAAPELLA-----QQGYDESCDLWSLGV 597
Query: 290 VLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKD 349
+LY+MLSG PF G G E+ +C+ I+EG++ + W +S EAK+
Sbjct: 598 ILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IREGRFSLDGEAWQGVSEEAKE 649
Query: 350 LISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP--TPQVLQRNSSTMDLTLFAAEAIA 407
L+ LL D +RL + W+Q + P TP VL+ + + L A +A
Sbjct: 650 LVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGL-NATFMA 708
Query: 408 LNR 410
NR
Sbjct: 709 FNR 711
Score = 94.7 bits (234), Expect = 2e-19
Identities = 89/342 (26%), Positives = 142/342 (41%), Gaps = 93/342 (27%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG GAY KV + A GK YA+K++ K A R++ T +++LE
Sbjct: 37 KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90
Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
L+ F+ D + +L+ + + GG + H+ ++++F E E ++ AL+
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILC 219
LH GI +RDLK EN+L
Sbjct: 151 HLHK-----------------------------------------LGIIYRDLKLENVLL 169
Query: 220 ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD 279
+S + + DF L + CG+ EYMAPE++ T +
Sbjct: 170 DSE---GHIVLTDFGLSKEFLTEEKERTFSF------CGTIEYMAPEIIR----SKTGHG 216
Query: 280 KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD 339
K D WSLG++L+ +L+G PF GE R Q ++ I + FP +
Sbjct: 217 KAVDWWSLGILLFELLTGASPFT---------LEGE--RNTQAEVSRRILKCSPPFPPR- 264
Query: 340 WAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQG 376
I A+DL+ +LL +D K+RL A +V HP+ QG
Sbjct: 265 ---IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQG 303
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 163 bits (413), Expect = 3e-40
Identities = 108/342 (31%), Positives = 159/342 (46%), Gaps = 66/342 (19%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L + LGEG+++ + V ++ + +AVKII K+ + +E+ L C+G+ NI++
Sbjct: 427 LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM---EANTQKEITALKLCEGHPNIVK 483
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSL 169
L E F D +LV E L GG + I+K+KHF+E EAS ++R + +A+ +H
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD------ 537
Query: 170 CHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVK 229
G+ HRDLKPEN+L +K
Sbjct: 538 -----------------------------------VGVVHRDLKPENLLFTDENDNLEIK 562
Query: 230 ICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGV 289
I DF P L TPC + Y APE++ YD+ CDLWSLGV
Sbjct: 563 IIDFGFAR-------LKPPDNQPLKTPCFTLHYAAPELLN-----QNGYDESCDLWSLGV 610
Query: 290 VLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKD 349
+LY MLSG PF H DR C ++ + I++G + F + W ++S EAKD
Sbjct: 611 ILYTMLSGQVPFQSH-------DRSLTC-TSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 662
Query: 350 LISKLLVRDAKQRLSAAQVLQHPWVQ--GQAPEKGLPTPQVL 389
LI LL D +RL + + + W+Q Q L TP +L
Sbjct: 663 LIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 704
Score = 96.3 bits (238), Expect = 5e-20
Identities = 87/335 (25%), Positives = 147/335 (43%), Gaps = 80/335 (23%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEK----QAGHSRSRVFREVETLYQCQGNK 105
++LG GAY KV + GK YA+K+++K Q + E + L + +
Sbjct: 53 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112
Query: 106 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKD 165
++ L F+ +T+ +L+ + + GG + H+ +++ F E E V ++ AL+ LH
Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHK-- 170
Query: 166 KVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKV 225
GI +RD+K ENIL +S
Sbjct: 171 ---------------------------------------LGIIYRDIKLENILLDSN--- 188
Query: 226 SPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLW 285
V + DF L + T + CG+ EYMAP++V + +DK D W
Sbjct: 189 GHVVLTDFGLSKEFVADE------TERAYSFCGTIEYMAPDIVR---GGDSGHDKAVDWW 239
Query: 286 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISS 345
SLGV++Y +L+G PF GE + Q ++ I + + +P + +S+
Sbjct: 240 SLGVLMYELLTGASPFTVD---------GE--KNSQAEISRRILKSEPPYPQE----MSA 284
Query: 346 EAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 375
AKDLI +LL++D K+RL A ++ +H + Q
Sbjct: 285 LAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 319
>gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
Length = 382
Score = 161 bits (407), Expect = 1e-39
Identities = 114/396 (28%), Positives = 184/396 (46%), Gaps = 84/396 (21%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE--DMYKLTSELLGEGAYAKVQGAVSL 69
E G P P+A G GR P K+ D Y+L+ ++LG G KV
Sbjct: 8 EQGGPVPPPVAPGGPGLGGAPGGRRE---PKKYAVTDDYQLSKQVLGLGVNGKVLECFHR 64
Query: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTR----FYLVFE 125
+ G++ A+K++ + + +EV+ +Q G +I+ +++ +E+ ++ E
Sbjct: 65 RTGQKCALKLL-----YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIME 119
Query: 126 KLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLT 183
++GG + + IQ++ + F EREA+ ++RD+ A+ FLH+ +
Sbjct: 120 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHN------------------ 161
Query: 184 AAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNN 243
IAHRD+KPEN+L S EK + +K+ DF N
Sbjct: 162 -----------------------IAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN- 197
Query: 244 SCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVG 303
L TPC + Y+APEV+ YDK CD+WSLGV++YI+L G+PPF
Sbjct: 198 --------ALQTPCYTPYYVAPEVLG-----PEKYDKSCDMWSLGVIMYILLCGFPPFYS 244
Query: 304 HCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL 363
+ G + + I+ G+Y FP+ +W+ +S +AK LI LL D +RL
Sbjct: 245 NTG-----------QAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERL 293
Query: 364 SAAQVLQHPWVQGQ--APEKGLPTPQVLQRNSSTMD 397
+ Q + HPW+ P+ L T +VLQ + D
Sbjct: 294 TITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD 329
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 160 bits (405), Expect = 2e-39
Identities = 117/372 (31%), Positives = 177/372 (47%), Gaps = 74/372 (19%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
+F D Y++ ++ G G+Y+ + + E+AVKII+K S+ E+E L +
Sbjct: 417 QFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDK----SKRDPTEEIEILLRYG 471
Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
+ NI+ L + ++D Y+V E ++GG +L I +QK F+EREAS V+ + +++LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 163 TKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENIL-CES 221
+ G+ HRDLKP NIL +
Sbjct: 532 AQ-----------------------------------------GVVHRDLKPSNILYVDE 550
Query: 222 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 281
++ICDF ++ N L TPC +A ++APEV++ YD
Sbjct: 551 SGNPESIRICDFGFAKQLRAENGL-------LMTPCYTANFVAPEVLK-----RQGYDAA 598
Query: 282 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 341
CD+WSLGV+LY ML+GY PF G D D E ++ I GK+ W
Sbjct: 599 CDIWSLGVLLYTMLTGYTPFAN--GPD---DTPE-------EILARIGSGKFSLSGGYWN 646
Query: 342 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF 401
+S AKDL+SK+L D QRL+AA VL+HPW+ LP Q+ ++++ +
Sbjct: 647 SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI---VHWDQLPQYQLNRQDAPHLVKGAM 703
Query: 402 AAEAIALNRQLS 413
AA ALNR S
Sbjct: 704 AATYSALNRNQS 715
Score = 84.3 bits (207), Expect = 2e-16
Identities = 85/329 (25%), Positives = 142/329 (43%), Gaps = 84/329 (25%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV--QGAVSLQNGKE-YAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G++ KV +S + ++ YA+K+++K R RV ++E
Sbjct: 65 PSQFELL-----KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
Query: 157 ALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPEN 216
ALD LH+ GI +RDLKPEN
Sbjct: 180 ALDHLHS-----------------------------------------LGIIYRDLKPEN 198
Query: 217 ILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQAT 276
IL + +K+ DF L S +++ + + CG+ EYMAPEVV
Sbjct: 199 ILLDEE---GHIKLTDFGL-SKESIDHE------KKAYSFCGTVEYMAPEVVN-----RR 243
Query: 277 FYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFP 336
+ + D WS GV+++ ML+G PF G DR E + I + K P
Sbjct: 244 GHTQSADWWSFGVLMFEMLTGTLPFQGK-------DRKETMTM--------ILKAKLGMP 288
Query: 337 DKDWAHISSEAKDLISKLLVRDAKQRLSA 365
+S EA+ L+ L R+ RL A
Sbjct: 289 Q----FLSPEAQSLLRMLFKRNPANRLGA 313
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 158 bits (400), Expect = 9e-39
Identities = 104/324 (32%), Positives = 155/324 (47%), Gaps = 71/324 (21%)
Query: 53 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 112
E+LG GA+++V GK +A+K I+K S + E+ L + + ++NI+ L +
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIK-HENIVTLED 85
Query: 113 FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHL 172
+E T +YLV + + GG + I ++ + E++AS V++ V +A+ +LH
Sbjct: 86 IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHEN-------- 137
Query: 173 GWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICD 232
GI HRDLKPEN+L +PE+ S + I D
Sbjct: 138 ---------------------------------GIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 233 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 292
F L S M+ N ++T CG+ Y+APEV+ Y K D WS+GV+ Y
Sbjct: 165 FGL-SKMEQNGI--------MSTACGTPGYVAPEVLAQKP-----YSKAVDCWSIGVITY 210
Query: 293 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 352
I+L GYPPF ++KLFE I+EG YEF W IS AKD I
Sbjct: 211 ILLCGYPPFYEET---------------ESKLFEKIKEGYYEFESPFWDDISESAKDFIC 255
Query: 353 KLLVRDAKQRLSAAQVLQHPWVQG 376
LL +D +R + + L HPW+ G
Sbjct: 256 HLLEKDPNERYTCEKALSHPWIDG 279
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 153 bits (387), Expect = 3e-37
Identities = 115/402 (28%), Positives = 181/402 (45%), Gaps = 94/402 (23%)
Query: 4 SQKLEKPIEMGSSEPLPIADGDRRRKK-KRRGRATDSLPGKFE----------------- 45
S +L P SS P + G R K GR++ ++ G E
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSE 385
Query: 46 -----DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ 100
+ YK+ +++G+G +A V+ + GKE+A+KII+K + + ++ +
Sbjct: 386 SSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 444
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L+E E T +LV E ++GG + I + ER+ S +V ++A AL +
Sbjct: 445 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 504
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENIL-C 219
LH GL+ I HRD+KPEN+L C
Sbjct: 505 LH------------------GLS-----------------------IVHRDIKPENLLVC 523
Query: 220 ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD 279
E P+ +K+ DF L + + L T CG+ Y+APE++ T Y
Sbjct: 524 EYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGTPTYVAPEIIA-----ETGYG 568
Query: 280 KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD 339
+ D+W+ GV+ YI+L G+PPF R E Q LF+ I GK EFP
Sbjct: 569 LKVDIWAAGVITYILLCGFPPF-----------RSE--NNLQEDLFDQILAGKLEFPAPY 615
Query: 340 WAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK 381
W +I+ AK+LIS++L + + R +A Q+L HPWV A ++
Sbjct: 616 WDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQE 657
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 153 bits (387), Expect = 3e-37
Identities = 115/403 (28%), Positives = 182/403 (45%), Gaps = 95/403 (23%)
Query: 4 SQKLEKPIEMGSSEPLPIADGDRRRKKK--RRGRATDSLPGKFE---------------- 45
S +L P SS P + G R K+ GR++ ++ G E
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCS 385
Query: 46 ------DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
+ YK+ +++G+G +A V+ + GKE+A+KII+K + + ++
Sbjct: 386 ESSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 444
Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
+ + NI+ L+E E T +LV E ++GG + I + ER+ S +V ++A AL
Sbjct: 445 RRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALR 504
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENIL- 218
+LH GL+ I HRD+KPEN+L
Sbjct: 505 YLH------------------GLS-----------------------IVHRDIKPENLLV 523
Query: 219 CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFY 278
CE P+ +K+ DF L + + L T CG+ Y+APE++ T Y
Sbjct: 524 CEYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGTPTYVAPEIIA-----ETGY 568
Query: 279 DKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDK 338
+ D+W+ GV+ YI+L G+PPF R E Q LF+ I GK EFP
Sbjct: 569 GLKVDIWAAGVITYILLCGFPPF-----------RSE--NNLQEDLFDQILAGKLEFPAP 615
Query: 339 DWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK 381
W +I+ AK+LIS++L + + R +A Q+L HPWV A ++
Sbjct: 616 YWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQE 658
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 152 bits (385), Expect = 5e-37
Identities = 104/333 (31%), Positives = 160/333 (48%), Gaps = 71/333 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
+F ++Y+L ++ G G+Y+ + + E+AVKII+K S+ E+E L +
Sbjct: 421 QFGEVYELKEDI-GVGSYSVCKRCIHATTNMEFAVKIIDK----SKRDPSEEIEILMRYG 475
Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
+ NI+ L + F+D YLV + ++GG +L I KQK F+EREAS ++ ++ +D+LH
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
Query: 163 TKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENIL-CES 221
+ G+ HRDLKP NIL +
Sbjct: 536 CQ-----------------------------------------GVVHRDLKPSNILYMDE 554
Query: 222 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 281
++ICDF ++ N L TPC +A ++APEV+ YD
Sbjct: 555 SASADSIRICDFGFAKQLRGENGL-------LLTPCYTANFVAPEVL-----MQQGYDAA 602
Query: 282 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 341
CD+WSLGV+ Y ML+GY PF A+ D E ++ I GK+ +W
Sbjct: 603 CDIWSLGVLFYTMLAGYTPF-----ANGPNDTPE-------EILLRIGNGKFSLSGGNWD 650
Query: 342 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
+IS AKDL+S +L D QR +A Q+L+H W+
Sbjct: 651 NISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI 683
Score = 89.0 bits (219), Expect = 8e-18
Identities = 84/332 (25%), Positives = 140/332 (42%), Gaps = 84/332 (25%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G++ KV + G+ YA+K+++K + R RV ++E
Sbjct: 70 PAQFELL-----KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 124
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 125 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 184
Query: 157 ALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPEN 216
ALD LH GI +RDLKPEN
Sbjct: 185 ALDHLHQ-----------------------------------------LGIVYRDLKPEN 203
Query: 217 ILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQAT 276
IL + ++ +K+ DF L + + CG+ EYMAPEVV
Sbjct: 204 ILLD---EIGHIKLTDFGLSKESVDQEK-------KAYSFCGTVEYMAPEVVN-----RR 248
Query: 277 FYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFP 336
+ + D WS GV+++ ML+G PF G DR N+ I + K P
Sbjct: 249 GHSQSADWWSYGVLMFEMLTGTLPFQGK-------DR--------NETMNMILKAKLGMP 293
Query: 337 DKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 368
+S+EA+ L+ L R+ RL + V
Sbjct: 294 Q----FLSAEAQSLLRMLFKRNPANRLGSEGV 321
>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
sapiens]
Length = 473
Score = 152 bits (385), Expect = 5e-37
Identities = 109/380 (28%), Positives = 170/380 (44%), Gaps = 90/380 (23%)
Query: 52 SELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELI 111
++ LG G V+ V + +A+KI+ R + EV C + NI+++I
Sbjct: 25 TQKLGAGISGPVRVCVKKSTQERFALKILL-----DRPKARNEVRLHMMCATHPNIVQII 79
Query: 112 EFFEDDTRF----------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFL 161
E F + +F +V E ++GG + I + +HF E++AS+V + +A AL
Sbjct: 80 EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH- 138
Query: 162 HTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCES 221
CHL IAHRDLKPEN+L +
Sbjct: 139 --------CHL--------------------------------LNIAHRDLKPENLLFKD 158
Query: 222 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE------------ 269
+PVK+CDF I +L TP + Y+AP+V+E
Sbjct: 159 NSLDAPVKLCDFGFAK----------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGI 208
Query: 270 VFTDQATF-YDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESI 328
+ T + Y+K CDLWSLGV++Y+ML GYPPF + R + I
Sbjct: 209 IPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----------RTIPKDMRRKI 258
Query: 329 QEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG-QAPEKGLPTPQ 387
G +EFP+++W+ IS AKD++ KLL ++RL+ VL HPW+ +A + LP+ Q
Sbjct: 259 MTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQ 318
Query: 388 VLQRNSSTMDLTLFAAEAIA 407
++ + + AE +A
Sbjct: 319 LMMDKAVVAGIQQAHAEQLA 338
>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
sapiens]
Length = 471
Score = 152 bits (385), Expect = 5e-37
Identities = 109/380 (28%), Positives = 170/380 (44%), Gaps = 90/380 (23%)
Query: 52 SELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELI 111
++ LG G V+ V + +A+KI+ R + EV C + NI+++I
Sbjct: 25 TQKLGAGISGPVRVCVKKSTQERFALKILL-----DRPKARNEVRLHMMCATHPNIVQII 79
Query: 112 EFFEDDTRF----------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFL 161
E F + +F +V E ++GG + I + +HF E++AS+V + +A AL
Sbjct: 80 EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH- 138
Query: 162 HTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCES 221
CHL IAHRDLKPEN+L +
Sbjct: 139 --------CHL--------------------------------LNIAHRDLKPENLLFKD 158
Query: 222 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE------------ 269
+PVK+CDF I +L TP + Y+AP+V+E
Sbjct: 159 NSLDAPVKLCDFGFAK----------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGI 208
Query: 270 VFTDQATF-YDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESI 328
+ T + Y+K CDLWSLGV++Y+ML GYPPF + R + I
Sbjct: 209 IPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----------RTIPKDMRRKI 258
Query: 329 QEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG-QAPEKGLPTPQ 387
G +EFP+++W+ IS AKD++ KLL ++RL+ VL HPW+ +A + LP+ Q
Sbjct: 259 MTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQ 318
Query: 388 VLQRNSSTMDLTLFAAEAIA 407
++ + + AE +A
Sbjct: 319 LMMDKAVVAGIQQAHAEQLA 338
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 152 bits (385), Expect = 5e-37
Identities = 104/346 (30%), Positives = 164/346 (47%), Gaps = 75/346 (21%)
Query: 40 LPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
+P + YK+ +G+G +A V+ V +EYA+KII+K + + + ++
Sbjct: 382 IPATITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSIL 440
Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
+ + NI+ LIE + T YLV E ++GG + I + ER+AS ++ ++A+A+
Sbjct: 441 RRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIK 500
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILC 219
+LH+ + I HRD+KPEN+L
Sbjct: 501 YLHSLN-----------------------------------------IVHRDIKPENLLV 519
Query: 220 -ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFY 278
E + +K+ DF L + I L T CG+ Y+APE++ T Y
Sbjct: 520 YEHQDGSKSLKLGDFGLAT----------IVDGPLYTVCGTPTYVAPEIIA-----ETGY 564
Query: 279 DKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDK 338
+ D+W+ GV+ YI+L G+PPF G G D Q LF+ I G+ +FP
Sbjct: 565 GLKVDIWAAGVITYILLCGFPPFRGS-GDD------------QEVLFDQILMGQVDFPSP 611
Query: 339 DWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP 384
W ++S AK+LI+ +L+ D QR SA QVL+HPWV + GLP
Sbjct: 612 YWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN----DDGLP 653
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 151 bits (381), Expect = 1e-36
Identities = 99/334 (29%), Positives = 167/334 (50%), Gaps = 72/334 (21%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQIL----- 121
Query: 161 LHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCE 220
+ V+ CHL GI HRDLKPEN+L
Sbjct: 122 ----ESVNHCHLN--------------------------------GIVHRDLKPENLLLA 145
Query: 221 SPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 280
S K + VK+ DF L ++ + G+ Y++PEV+ + Y K
Sbjct: 146 SKSKGAAVKLADFGLAIEVQGDQQAW-------FGFAGTPGYLSPEVL-----RKDPYGK 193
Query: 281 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDW 340
D+W+ GV+LYI+L GYPPF WD Q++L++ I+ G Y+FP +W
Sbjct: 194 PVDMWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGAYDFPSPEW 238
Query: 341 AHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 374
++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|32481209 mitogen-activated protein kinase-activated protein
kinase 2 isoform 2 [Homo sapiens]
Length = 400
Score = 150 bits (380), Expect = 2e-36
Identities = 103/355 (29%), Positives = 169/355 (47%), Gaps = 78/355 (21%)
Query: 46 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105
D YK+TS++LG G KV + + +++A+K+++ + REVE ++
Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115
Query: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159
+I+ +++ +E+ +V E L GG + + IQ + + F EREAS +++ + A+
Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILC 219
+LH+ IAHRD+KPEN+L
Sbjct: 176 YLHS-----------------------------------------INIAHRDVKPENLLY 194
Query: 220 ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD 279
S + +K+ DF +NS LTTPC + Y+APEV+ YD
Sbjct: 195 TSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTPYYVAPEVLG-----PEKYD 241
Query: 280 KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD 339
K CD+WSLGV++YI+L GYPPF + G + I+ G+YEFP+ +
Sbjct: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISPGMKTRIRMGQYEFPNPE 290
Query: 340 WAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--QGQAPEKGLPTPQVLQRN 392
W+ +S E K LI LL + QR++ + + HPW+ + P+ L T +VL+ +
Sbjct: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 345
>gi|10863901 mitogen-activated protein kinase-activated protein
kinase 2 isoform 1 [Homo sapiens]
Length = 370
Score = 150 bits (380), Expect = 2e-36
Identities = 103/355 (29%), Positives = 169/355 (47%), Gaps = 78/355 (21%)
Query: 46 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105
D YK+TS++LG G KV + + +++A+K+++ + REVE ++
Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115
Query: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159
+I+ +++ +E+ +V E L GG + + IQ + + F EREAS +++ + A+
Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
Query: 160 FLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILC 219
+LH+ IAHRD+KPEN+L
Sbjct: 176 YLHS-----------------------------------------INIAHRDVKPENLLY 194
Query: 220 ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD 279
S + +K+ DF +NS LTTPC + Y+APEV+ YD
Sbjct: 195 TSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTPYYVAPEVLG-----PEKYD 241
Query: 280 KRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKD 339
K CD+WSLGV++YI+L GYPPF + G + I+ G+YEFP+ +
Sbjct: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISPGMKTRIRMGQYEFPNPE 290
Query: 340 WAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--QGQAPEKGLPTPQVLQRN 392
W+ +S E K LI LL + QR++ + + HPW+ + P+ L T +VL+ +
Sbjct: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 345
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 150 bits (379), Expect = 2e-36
Identities = 118/419 (28%), Positives = 180/419 (42%), Gaps = 81/419 (19%)
Query: 10 PIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSL 69
P G +EP P R R K R + + K++ L+G G++++V
Sbjct: 65 PPTAGHTEP-PSEPPRRARVAKYRAKFDPRVTAKYD-----IKALIGRGSFSRVVRVEHR 118
Query: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQG 129
+ YA+K+IE + R E+ L + + + NI++L+E FE R Y+V E G
Sbjct: 119 ATRQPYAIKMIETKYREGREVCESELRVLRRVR-HANIIQLVEVFETQERVYMVMELATG 177
Query: 130 GSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSL 189
G + I + F ER+A+RV++ V + +LH
Sbjct: 178 GELFDRIIAKGSFTERDATRVLQMVLDGVRYLHA-------------------------- 211
Query: 190 GSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPIT 249
GI HRDLKPEN+L P S + I DF L S K + C T
Sbjct: 212 ---------------LGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKT 256
Query: 250 TPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADC 309
T CG+ EY+APEV+ Y D+W+LGV+ YI+LSG PF
Sbjct: 257 T------CGTPEYIAPEVLV-----RKPYTNSVDMWALGVIAYILLSGTMPFEDDN---- 301
Query: 310 GWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 369
+ +L+ I GKY + + W +S+ AKD I +LL D R++A Q L
Sbjct: 302 -----------RTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQAL 350
Query: 370 QHPWVQGQAPEKGLP------TPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAE 422
+HPWV A + + +L+R SS T +A++ +R ++ + E
Sbjct: 351 RHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTK-SAQSTRSSRSTRSNKSRRVRE 408
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,099,386
Number of Sequences: 37866
Number of extensions: 878981
Number of successful extensions: 5263
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 422
Number of HSP's successfully gapped in prelim test: 285
Number of HSP's that attempted gapping in prelim test: 3112
Number of HSP's gapped (non-prelim): 1361
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.