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Search of human proteins with 21361077
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361077 calcium channel, voltage-dependent, T type, alpha
1I subunit isoform a [Homo sapiens]
(2223 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 4531 0.0
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 4434 0.0
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 1603 0.0
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 1595 0.0
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 1507 0.0
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 1503 0.0
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 1490 0.0
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 1489 0.0
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 1476 0.0
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 1474 0.0
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 1471 0.0
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 1469 0.0
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 1461 0.0
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 1461 0.0
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 1457 0.0
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 1456 0.0
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 1448 0.0
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 1444 0.0
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i... 818 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 523 e-148
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 354 6e-97
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 343 8e-94
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 343 8e-94
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 343 8e-94
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 342 2e-93
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 338 5e-92
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 338 5e-92
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 338 5e-92
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 337 8e-92
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 337 8e-92
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 4531 bits (11751), Expect = 0.0
Identities = 2223/2223 (100%), Positives = 2223/2223 (100%)
Query: 1 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
Sbjct: 1 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
Query: 61 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
Sbjct: 61 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
Query: 121 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
Sbjct: 121 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
Query: 181 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
Sbjct: 181 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
Query: 241 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
Sbjct: 241 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
Query: 301 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
Sbjct: 301 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
Query: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
Sbjct: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
Query: 421 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
Sbjct: 421 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
Query: 481 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ 540
AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ
Sbjct: 481 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ 540
Query: 541 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 600
PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
Sbjct: 541 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 600
Query: 601 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 660
ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
Sbjct: 601 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 660
Query: 661 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 720
HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
Sbjct: 661 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 720
Query: 721 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 780
GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
Sbjct: 721 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 780
Query: 781 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 840
MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
Sbjct: 781 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 840
Query: 841 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 900
YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
Sbjct: 841 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 900
Query: 901 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 960
PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
Sbjct: 901 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 960
Query: 961 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 1020
SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
Sbjct: 961 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 1020
Query: 1021 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1080
AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
Sbjct: 1021 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1080
Query: 1081 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1140
AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
Sbjct: 1081 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1140
Query: 1141 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1200
WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
Sbjct: 1141 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1200
Query: 1201 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1260
RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
Sbjct: 1201 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1260
Query: 1261 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1320
SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
Sbjct: 1261 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1320
Query: 1321 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1380
GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
Sbjct: 1321 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1380
Query: 1381 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1440
GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
Sbjct: 1381 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1440
Query: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500
QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
Sbjct: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500
Query: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560
VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
Sbjct: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560
Query: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620
LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
Sbjct: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620
Query: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1680
NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
Sbjct: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1680
Query: 1681 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1740
NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
Sbjct: 1681 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1740
Query: 1741 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1800
QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
Sbjct: 1741 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1800
Query: 1801 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1860
LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
Sbjct: 1801 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1860
Query: 1861 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1920
DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
Sbjct: 1861 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1920
Query: 1921 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1980
FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
Sbjct: 1921 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1980
Query: 1981 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2040
GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
Sbjct: 1981 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2040
Query: 2041 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2100
SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
Sbjct: 2041 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2100
Query: 2101 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2160
DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
Sbjct: 2101 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2160
Query: 2161 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2220
APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
Sbjct: 2161 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2220
Query: 2221 RKR 2223
RKR
Sbjct: 2221 RKR 2223
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 4434 bits (11499), Expect = 0.0
Identities = 2187/2223 (98%), Positives = 2188/2223 (98%), Gaps = 35/2223 (1%)
Query: 1 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF
Sbjct: 1 MAESASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFF 60
Query: 61 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD
Sbjct: 61 CLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDD 120
Query: 121 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV
Sbjct: 121 FIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTV 180
Query: 181 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF
Sbjct: 181 RVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF 240
Query: 241 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV
Sbjct: 241 LEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDV 300
Query: 301 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV
Sbjct: 301 YDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWV 360
Query: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL
Sbjct: 361 EIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYL 420
Query: 421 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH
Sbjct: 421 SSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPH 480
Query: 481 AKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQ 540
AKEPRHY +LCPQHSPLDATPHTLVQ
Sbjct: 481 AKEPRHY-----------------------------------QLCPQHSPLDATPHTLVQ 505
Query: 541 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 600
PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG
Sbjct: 506 PIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDG 565
Query: 601 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 660
ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE
Sbjct: 566 ASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE 625
Query: 661 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 720
HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV
Sbjct: 626 HHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV 685
Query: 721 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 780
GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG
Sbjct: 686 GQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILG 745
Query: 781 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 840
MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL
Sbjct: 746 MHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL 805
Query: 841 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 900
YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD
Sbjct: 806 YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGD 865
Query: 901 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 960
PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM
Sbjct: 866 PKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRM 925
Query: 961 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 1020
SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV
Sbjct: 926 SYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEV 985
Query: 1021 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1080
AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA
Sbjct: 986 AADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRA 1045
Query: 1081 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1140
AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD
Sbjct: 1046 AWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPD 1105
Query: 1141 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1200
WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE
Sbjct: 1106 WCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTE 1165
Query: 1201 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1260
RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA
Sbjct: 1166 RIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLA 1225
Query: 1261 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1320
SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF
Sbjct: 1226 SAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIF 1285
Query: 1321 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1380
GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD
Sbjct: 1286 GILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKD 1345
Query: 1381 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1440
GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH
Sbjct: 1346 GWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH 1405
Query: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500
QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN
Sbjct: 1406 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1465
Query: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560
VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL
Sbjct: 1466 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1525
Query: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620
LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG
Sbjct: 1526 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1585
Query: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1680
NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW
Sbjct: 1586 NLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNW 1645
Query: 1681 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1740
NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA
Sbjct: 1646 NGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEA 1705
Query: 1741 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1800
QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN
Sbjct: 1706 QEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQEN 1765
Query: 1801 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1860
LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS
Sbjct: 1766 LWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNS 1825
Query: 1861 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1920
DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN
Sbjct: 1826 DRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPEN 1885
Query: 1921 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1980
FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT
Sbjct: 1886 FLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGT 1945
Query: 1981 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2040
GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD
Sbjct: 1946 GTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSD 2005
Query: 2041 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2100
SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH
Sbjct: 2006 SPRRALGPPAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHH 2065
Query: 2101 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2160
DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA
Sbjct: 2066 DSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCPPPPPPAPGLTPARKFSSTSSLA 2125
Query: 2161 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2220
APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK
Sbjct: 2126 APGRPHAAALAHGLARSPSWAADRSKDPPGRAPLPMGLGPLAPPPQPLPGELEPGDAASK 2185
Query: 2221 RKR 2223
RKR
Sbjct: 2186 RKR 2188
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 1603 bits (4152), Expect = 0.0
Identities = 928/1651 (56%), Positives = 1086/1651 (65%), Gaps = 155/1651 (9%)
Query: 489 GKTKGQ---GDEGRHLGSRHCQTLHGPASPGND-----------HSGRELCPQHSPLDAT 534
G KG G +G+ G HGP S + G P H +
Sbjct: 622 GSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSV 681
Query: 535 PHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG- 593
P L P TL + SCP C L ++SG + G G +D GD
Sbjct: 682 PCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG-DSDGRGVYEFTQDVRHGDRW 740
Query: 594 ------ARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIM 647
+ G + ++ A G G +W KLR IVDSKYF+RGIM
Sbjct: 741 DPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIM 800
Query: 648 MAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIF 707
MAILVNT+SMG+E+HEQPEELTN LEI N+VFTSMFALEM+LKL A G Y+RNPYNIF
Sbjct: 801 MAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIF 860
Query: 708 DSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCM 767
D IIV+IS+WEIVGQADGGLSVLRTFRLLRVLKLVRF+PALRRQLVVL+KTMDNVATFC
Sbjct: 861 DGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCT 920
Query: 768 LLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 827
LLMLFIFIFSILGMH+FGCKFSL+TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL
Sbjct: 921 LLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 980
Query: 828 YNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE 887
YNGMASTS WA+LYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRS +DED++S + EE
Sbjct: 981 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEE 1040
Query: 888 -FDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQP--DPML 944
F KL+E + + K+C + +TPNGHL+ L L AA P P P D
Sbjct: 1041 DFHKLREL--QTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAP 1098
Query: 945 VALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKP 998
SR+ S S DQ+ +S RSS PWG S AW+SRRSSW+SL K +
Sbjct: 1099 SLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRG 1158
Query: 999 PSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLS 1058
E ESLLS E G + A++G RAAP GP R RR S
Sbjct: 1159 QCGERESLLSGEGKGST---DDEAEDG--RAAP-----------GP----RATPLRRAES 1198
Query: 1059 LDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGE 1117
LD PR AA P D +G++ ++ D F ++ R D E
Sbjct: 1199 LD-----------------PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAE 1241
Query: 1118 DEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVL 1177
+++ + + C R+ K+++ YKP WC RE W++YLFSP+NRFRV CQ +I HK+FD+VVL
Sbjct: 1242 LDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVL 1301
Query: 1178 AFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLR 1237
FIFLNC+TIALERP I+ GSTER+FL+VSNYIFTAIFV EM +KVV+LGL GE AYL+
Sbjct: 1302 VFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQ 1361
Query: 1238 SSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1297
SSWN+LDG LV VS++DIVV++ASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
Sbjct: 1362 SSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1421
Query: 1298 TLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWV 1357
TLISSL+PIGNIVLICCAFFIIFGILGVQLFKGKFY+C G DTRNI+ ++ C AA+YRWV
Sbjct: 1422 TLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWV 1481
Query: 1358 HHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLI 1417
KYNFDNLGQALMSLFVL+SKDGWVNIMY+GLDAV VDQQPV NHNPWMLLYFISFLLI
Sbjct: 1482 RRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLI 1541
Query: 1418 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTR 1477
VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLE++RRKAQR PYYA Y TR
Sbjct: 1542 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTR 1601
Query: 1478 LLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLK 1537
IHS+CTSHYLD+FITFIIC+NV+TMS+EHYNQP SL+ ALKYCNY+FT VFV EA LK
Sbjct: 1602 RSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALK 1661
Query: 1538 LVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLK 1597
LVAFG RRFFKDRWNQLDLAIVLLS+MGITLEEIE++AALPINPTIIRIMRVLRIARVLK
Sbjct: 1662 LVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLK 1721
Query: 1598 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSR 1657
LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG+L C+++NPCEG+SR
Sbjct: 1722 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSR 1781
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
HATF NFGMAFLTLF+VSTGDNWNGIMKDTLR+C+ +++ CLS L +SP+YFV+FVL A
Sbjct: 1782 HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVA 1841
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPG 1777
QFVL+NVVVAVLMKHL++SNKEA+EDAE+DAE+ELEMA G G R+ P P PG
Sbjct: 1842 QFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPG 1901
Query: 1778 GAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAG 1837
D+ +L+ + + + N S + P
Sbjct: 1902 AR------------------------DAPNLVARKVSVSRMLSLPNDS-----YMFRPVV 1932
Query: 1838 CKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPP--- 1894
H + +Q E E + + LG S+ P A +S L P
Sbjct: 1933 PASAPHPR-PLQEVEMETYGAGTP------LGSVASVHSPPA------ESCASLQIPLAV 1979
Query: 1895 -EPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDA 1953
P R G+ P TA SP LC E + + + K DS + P P
Sbjct: 1980 SSPARSGEPLHALSP-RGTARSPSLSRLLCRQEAVHTDSLEG--KIDSPRDTLDPAEPGE 2036
Query: 1954 SSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGS 2013
+P+ P+ T G+L + RSPR R+ T
Sbjct: 2037 KTPVRPV-------------------TQGGSLQ--------SPPRSPRPASVRTRKHTFG 2069
Query: 2014 DTSLDASPSSSAGSLQTTLEDS------LTLSDSPRRALGPP-APAPGPRAGLSPAARRR 2066
+ + P++ G + + +T S P + P P P AG RR
Sbjct: 2070 QRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRL 2129
Query: 2067 LSLRGRGLFSLRGLRAHQ-RSHSSGGSTSPG 2096
S+ +G G Q R + GS PG
Sbjct: 2130 YSVDAQGFLDKPGRADEQWRPSAELGSGEPG 2160
Score = 626 bits (1614), Expect = e-179
Identities = 326/528 (61%), Positives = 377/528 (71%), Gaps = 19/528 (3%)
Query: 7 PPSSSAAAPAAEPGVTTEQPGPRS-----------PPSSPPGLEEPLD-GADPH--VPHP 52
P + PAA G + E PG PS P E + GAD VP+P
Sbjct: 14 PLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYP 73
Query: 53 DLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRC 112
LA FFCL QTT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC
Sbjct: 74 ALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133
Query: 113 KILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNI 172
IL+ FD FIF FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD N+
Sbjct: 134 NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV 193
Query: 173 NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+LSAIRTVRVLRPL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWA
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
Query: 233 GLLRNRCFLEENFTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGR 291
GLLRNRCFL+ F ++ L PYYQ EE +E PFICS DNG+ C IP +E
Sbjct: 254 GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRM 313
Query: 292 ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIF 351
C L + Y A C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IF
Sbjct: 314 PCTLGW-EAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIF 372
Query: 352 QVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRL 411
QVITLEGWV+IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +L
Sbjct: 373 QVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 432
Query: 412 MLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGP 469
M EQR R+LS+ ST+AS++EPG CYEE+ +YV HI RK KRR+L LY QSR R+ + P
Sbjct: 433 MREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDP 492
Query: 470 EAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG-PASPG 516
A PG + + H H HG P PG
Sbjct: 493 SAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540
Score = 116 bits (290), Expect = 3e-25
Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)
Query: 1158 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1215
R R C ++ + F++V + I LNC+T+ + RP +E GS L + A F
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
Query: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
EM +K+V+LGL FG++ YL +WN LD F+V +++ S G + L +R
Sbjct: 148 AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199
Query: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
+R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL+ G +
Sbjct: 200 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259
Query: 1336 LGVDTRNITNRS 1347
+D+ + N +
Sbjct: 260 CFLDSAFVRNNN 271
Score = 109 bits (272), Expect = 3e-23
Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131
C K++ + F+ V ++ I LNCVT+ + +P D+D S L V + F EM+
Sbjct: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
Query: 132 LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183
+K+VALG+ G+ YL +WN LD +V+ +V+ + + + L +R +R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
Query: 184 RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
RPL+ I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL+ G
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
Score = 85.1 bits (209), Expect = 7e-16
Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)
Query: 560 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 605
+G R + G G + G E+ G R +E G+ +EL
Sbjct: 3 EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62
Query: 606 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 659
G +EE+ V+ C R+ +V + +F M+ I++N V++G+
Sbjct: 63 GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122
Query: 660 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 715
E E E NILE + + FA+EM++K+ A GLF YL + +N D IV+
Sbjct: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182
Query: 716 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 772
+ E DG LS +RT R+LR L+ + +P++R + +L+ T+ + +L
Sbjct: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
Query: 773 IFIFSILGMHIF 784
FIF I+G+ ++
Sbjct: 241 FFIFGIVGVQLW 252
Score = 71.6 bits (174), Expect = 8e-12
Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 21/180 (11%)
Query: 67 SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF 125
SP I +C + + +I +N +T+ M + + L + K +F+F
Sbjct: 1598 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVF 1656
Query: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA--------- 176
E LK+VA FG + + D WN+LD IV+ ++ + L+ I +SA
Sbjct: 1657 ---EAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINPTII 1708
Query: 177 --IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
+R +R+ R LK + MR L++ ++ LP +GN+ LL +FFI+ +GV+L+ L
Sbjct: 1709 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRL 1768
Score = 71.2 bits (173), Expect = 1e-11
Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1546
+I LN VT+ + + +E + CN + F +E V+K+VA GL + +
Sbjct: 109 VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166
Query: 1547 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1606
D WN+LD IV+ +M +L+ ++ + +R +R+ R L+ + MR
Sbjct: 167 LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217
Query: 1607 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
L+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 218 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
Score = 60.1 bits (144), Expect = 2e-08
Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
++V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++A G G Y+ + +N D IV+ + E + + LS +RT R+LR LK +
Sbjct: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P++R + +L+ T+ + L FIF I+G+ L+
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 58.9 bits (141), Expect = 5e-08
Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)
Query: 1362 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1421
NFDN+G A +++F + + +GWV+IMY +DA H+ + +YFI +++ SFF
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409
Query: 1422 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
++N+ + V+ F + +Q E++ E+R R L
Sbjct: 410 MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441
Score = 56.6 bits (135), Expect = 3e-07
Identities = 33/103 (32%), Positives = 55/103 (53%), Gaps = 12/103 (11%)
Query: 326 CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375
CR + NFDN+G A + +F + + +GWV IMY +DA H+ +
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
Query: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQR 418
+YFI +++ SFF++N+ + V+ F K R+H+ E R+R
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFH--KCRQHQEAEEARRR 1573
Score = 48.5 bits (114), Expect = 7e-05
Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)
Query: 328 TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387
TG P + NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++
Sbjct: 947 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004
Query: 388 FMINLCLVVIATQF 401
+ NL + ++ F
Sbjct: 1005 VLFNLLVAILVEGF 1018
Score = 47.8 bits (112), Expect = 1e-04
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 794 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 851
+GD+ P NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++
Sbjct: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408
Query: 852 VLFNLLVAILVEGF 865
+ NL + ++ F
Sbjct: 409 FMINLCLVVIATQF 422
Score = 38.9 bits (89), Expect = 0.057
Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
D NP G F+N G A++ +FQV T + W IM + + F +
Sbjct: 351 DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 397 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
Score = 35.8 bits (81), Expect = 0.48
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)
Query: 332 NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377
NP +G F N G A++ +F+V T + W IM + D H +Y
Sbjct: 1774 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1833
Query: 378 FILLIIVGSFFMINLCLVVIATQFSETKQ 406
F+ ++V F ++N+ + V+ E+ +
Sbjct: 1834 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1862
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 1595 bits (4131), Expect = 0.0
Identities = 927/1657 (55%), Positives = 1086/1657 (65%), Gaps = 161/1657 (9%)
Query: 489 GKTKGQ---GDEGRHLGSRHCQTLHGPASPGND-----------HSGRELCPQHSPLDAT 534
G KG G +G+ G HGP S + G P H +
Sbjct: 622 GSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSV 681
Query: 535 PHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG- 593
P L P TL + SCP C L ++SG + G G +D GD
Sbjct: 682 PCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG-DSDGRGVYEFTQDVRHGDRW 740
Query: 594 ------ARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIM 647
+ G + ++ A G G +W KLR IVDSKYF+RGIM
Sbjct: 741 DPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIM 800
Query: 648 MAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIF 707
MAILVNT+SMG+E+HEQPEELTN LEI N+VFTSMFALEM+LKL A G Y+RNPYNIF
Sbjct: 801 MAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIF 860
Query: 708 DSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCM 767
D IIV+IS+WEIVGQADGGLSVLRTFRLLRVLKLVRF+PALRRQLVVL+KTMDNVATFC
Sbjct: 861 DGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCT 920
Query: 768 LLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 827
LLMLFIFIFSILGMH+FGCKFSL+TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL
Sbjct: 921 LLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 980
Query: 828 YNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE 887
YNGMASTS WA+LYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRS +DED++S + EE
Sbjct: 981 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEE 1040
Query: 888 -FDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQP--DPML 944
F KL+E + + K+C + +TPNGHL+ L L AA P P P D
Sbjct: 1041 DFHKLREL--QTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAP 1098
Query: 945 VALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKP 998
SR+ S S DQ+ +S RSS PWG S AW+SRRSSW+SL K +
Sbjct: 1099 SLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRG 1158
Query: 999 PSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLS 1058
E ESLLS E G + A++G RAAP GP R RR S
Sbjct: 1159 QCGERESLLSGEGKGST---DDEAEDG--RAAP-----------GP----RATPLRRAES 1198
Query: 1059 LDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGE 1117
LD PR AA P D +G++ ++ D F ++ R D E
Sbjct: 1199 LD-----------------PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAE 1241
Query: 1118 DEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVL 1177
+++ + + C R+ K+++ YKP WC RE W++YLFSP+NRFRV CQ +I HK+FD+VVL
Sbjct: 1242 LDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVL 1301
Query: 1178 AFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLR 1237
FIFLNC+TIALERP I+ GSTER+FL+VSNYIFTAIFV EM +KVV+LGL GE AYL+
Sbjct: 1302 VFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQ 1361
Query: 1238 SSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1297
SSWN+LDG LV VS++DIVV++ASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
Sbjct: 1362 SSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1421
Query: 1298 TLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWV 1357
TLISSL+PIGNIVLICCAFFIIFGILGVQLFKGKFY+C G DTRNI+ ++ C AA+YRWV
Sbjct: 1422 TLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWV 1481
Query: 1358 HHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLI 1417
KYNFDNLGQALMSLFVL+SKDGWVNIMY+GLDAV VDQQPV NHNPWMLLYFISFLLI
Sbjct: 1482 RRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLI 1541
Query: 1418 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR------KAQRLPYYA 1471
VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLE++RR +AQR PYYA
Sbjct: 1542 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYA 1601
Query: 1472 TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFV 1531
Y TR IHS+CTSHYLD+FITFIIC+NV+TMS+EHYNQP SL+ ALKYCNY+FT VFV
Sbjct: 1602 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFV 1661
Query: 1532 LEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1591
EA LKLVAFG RRFFKDRWNQLDLAIVLLS+MGITLEEIE++AALPINPTIIRIMRVLR
Sbjct: 1662 FEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLR 1721
Query: 1592 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENP 1651
IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG+L C+++NP
Sbjct: 1722 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNP 1781
Query: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFV 1711
CEG+SRHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR+C+ +++ CLS L +SP+YFV
Sbjct: 1782 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFV 1841
Query: 1712 SFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGA 1771
+FVL AQFVL+NVVVAVLMKHL++SNKEA+EDAE+DAE+ELEMA G G R+ P
Sbjct: 1842 TFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPL 1901
Query: 1772 PGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHH 1831
P PG D+ +L+ + + + N S +
Sbjct: 1902 PQESPGAR------------------------DAPNLVARKVSVSRMLSLPNDS-----Y 1932
Query: 1832 YSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGEL 1891
P H + +Q E E + + LG S+ P A +S L
Sbjct: 1933 MFRPVVPASAPHPR-PLQEVEMETYGAGTP------LGSVASVHSPPA------ESCASL 1979
Query: 1892 DPP----EPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPS 1947
P P R G+ P TA SP LC E + + + K DS +
Sbjct: 1980 QIPLAVSSPARSGEPLHALSP-RGTARSPSLSRLLCRQEAVHTDSLEG--KIDSPRDTLD 2036
Query: 1948 PFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLL 2007
P P +P+ P+ T G+L + RSPR
Sbjct: 2037 PAEPGEKTPVRPV-------------------TQGGSLQ--------SPPRSPRPASVRT 2069
Query: 2008 RQATGSDTSLDASPSSSAGSLQTTLEDS------LTLSDSPRRALGPP-APAPGPRAGLS 2060
R+ T + + P++ G + + +T S P + P P P AG
Sbjct: 2070 RKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGE 2129
Query: 2061 PAARRRLSLRGRGLFSLRGLRAHQ-RSHSSGGSTSPG 2096
RR S+ +G G Q R + GS PG
Sbjct: 2130 RDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPG 2166
Score = 626 bits (1614), Expect = e-179
Identities = 326/528 (61%), Positives = 377/528 (71%), Gaps = 19/528 (3%)
Query: 7 PPSSSAAAPAAEPGVTTEQPGPRS-----------PPSSPPGLEEPLD-GADPH--VPHP 52
P + PAA G + E PG PS P E + GAD VP+P
Sbjct: 14 PLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYP 73
Query: 53 DLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRC 112
LA FFCL QTT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC
Sbjct: 74 ALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133
Query: 113 KILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNI 172
IL+ FD FIF FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD N+
Sbjct: 134 NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV 193
Query: 173 NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+LSAIRTVRVLRPL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWA
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
Query: 233 GLLRNRCFLEENFTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGR 291
GLLRNRCFL+ F ++ L PYYQ EE +E PFICS DNG+ C IP +E
Sbjct: 254 GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRM 313
Query: 292 ECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIF 351
C L + Y A C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IF
Sbjct: 314 PCTLGW-EAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIF 372
Query: 352 QVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRL 411
QVITLEGWV+IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +L
Sbjct: 373 QVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQL 432
Query: 412 MLEQRQRYLSS-STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGP 469
M EQR R+LS+ ST+AS++EPG CYEE+ +YV HI RK KRR+L LY QSR R+ + P
Sbjct: 433 MREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDP 492
Query: 470 EAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG-PASPG 516
A PG + + H H HG P PG
Sbjct: 493 SAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540
Score = 116 bits (290), Expect = 3e-25
Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)
Query: 1158 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1215
R R C ++ + F++V + I LNC+T+ + RP +E GS L + A F
Sbjct: 88 RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
Query: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
EM +K+V+LGL FG++ YL +WN LD F+V +++ S G + L +R
Sbjct: 148 AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199
Query: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
+R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL+ G +
Sbjct: 200 TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259
Query: 1336 LGVDTRNITNRS 1347
+D+ + N +
Sbjct: 260 CFLDSAFVRNNN 271
Score = 109 bits (272), Expect = 3e-23
Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131
C K++ + F+ V ++ I LNCVT+ + +P D+D S L V + F EM+
Sbjct: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
Query: 132 LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183
+K+VALG+ G+ YL +WN LD +V+ +V+ + + + L +R +R L
Sbjct: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
Query: 184 RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
RPL+ I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL+ G
Sbjct: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
Score = 85.1 bits (209), Expect = 7e-16
Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)
Query: 560 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 605
+G R + G G + G E+ G R +E G+ +EL
Sbjct: 3 EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62
Query: 606 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 659
G +EE+ V+ C R+ +V + +F M+ I++N V++G+
Sbjct: 63 GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122
Query: 660 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 715
E E E NILE + + FA+EM++K+ A GLF YL + +N D IV+
Sbjct: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182
Query: 716 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 772
+ E DG LS +RT R+LR L+ + +P++R + +L+ T+ + +L
Sbjct: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
Query: 773 IFIFSILGMHIF 784
FIF I+G+ ++
Sbjct: 241 FFIFGIVGVQLW 252
Score = 71.6 bits (174), Expect = 8e-12
Identities = 51/180 (28%), Positives = 88/180 (48%), Gaps = 21/180 (11%)
Query: 67 SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF 125
SP I +C + + +I +N +T+ M + + L + K +F+F
Sbjct: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSM-EHYNQPKSLDEALKYCNYVFTIVFVF 1662
Query: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA--------- 176
E LK+VA FG + + D WN+LD IV+ ++ + L+ I +SA
Sbjct: 1663 ---EAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINPTII 1714
Query: 177 --IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
+R +R+ R LK + MR L++ ++ LP +GN+ LL +FFI+ +GV+L+ L
Sbjct: 1715 RIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRL 1774
Score = 71.2 bits (173), Expect = 1e-11
Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1546
+I LN VT+ + + +E + CN + F +E V+K+VA GL + +
Sbjct: 109 VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166
Query: 1547 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1606
D WN+LD IV+ +M +L+ ++ + +R +R+ R L+ + MR
Sbjct: 167 LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217
Query: 1607 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
L+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 218 ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
Score = 60.1 bits (144), Expect = 2e-08
Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
++V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++A G G Y+ + +N D IV+ + E + + LS +RT R+LR LK +
Sbjct: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P++R + +L+ T+ + L FIF I+G+ L+
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 58.9 bits (141), Expect = 5e-08
Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)
Query: 1362 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1421
NFDN+G A +++F + + +GWV+IMY +DA H+ + +YFI +++ SFF
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409
Query: 1422 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
++N+ + V+ F + +Q E++ E+R R L
Sbjct: 410 MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441
Score = 57.4 bits (137), Expect = 2e-07
Identities = 35/120 (29%), Positives = 60/120 (50%), Gaps = 14/120 (11%)
Query: 326 CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375
CR + NFDN+G A + +F + + +GWV IMY +DA H+ +
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
Query: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
+YFI +++ SFF++N+ + V+ F + +Q E R E+R R L +++ P
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSP 1592
Score = 48.5 bits (114), Expect = 7e-05
Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)
Query: 328 TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387
TG P + NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++
Sbjct: 947 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004
Query: 388 FMINLCLVVIATQF 401
+ NL + ++ F
Sbjct: 1005 VLFNLLVAILVEGF 1018
Score = 47.8 bits (112), Expect = 1e-04
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)
Query: 794 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 851
+GD+ P NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++
Sbjct: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408
Query: 852 VLFNLLVAILVEGF 865
+ NL + ++ F
Sbjct: 409 FMINLCLVVIATQF 422
Score = 38.9 bits (89), Expect = 0.057
Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
D NP G F+N G A++ +FQV T + W IM + + F +
Sbjct: 351 DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 397 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
Score = 35.8 bits (81), Expect = 0.48
Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)
Query: 332 NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377
NP +G F N G A++ +F+V T + W IM + D H +Y
Sbjct: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
Query: 378 FILLIIVGSFFMINLCLVVIATQFSETKQ 406
F+ ++V F ++N+ + V+ E+ +
Sbjct: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 1507 bits (3902), Expect = 0.0
Identities = 924/1753 (52%), Positives = 1100/1753 (62%), Gaps = 210/1753 (11%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1472
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
Query: 1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1532
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Query: 1533 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1652
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
Query: 1653 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1712
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGS---- 1768
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GS
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSPFLW 1858
Query: 1769 PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIID 1822
PG G PG P L+ D++SL+I+ SLE EL ++D
Sbjct: 1859 PGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMD 1917
Query: 1823 NLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLEDP- 1877
L+G + P+ D Q + LAE EA SL S+ S S+ L DD SL D
Sbjct: 1918 ELAGPGGQPSAFPSAPSLGGSDPQ-IPLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDM 1975
Query: 1878 -----TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
+A + EL P+ + V G +S T P+ ++++C P
Sbjct: 1976 HTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 2029
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 2030 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKL 2083
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 2084 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2138
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2139 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2198
Query: 2070 ------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2199 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2255
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2256 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2310
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2311 ASGPPDSMAASPS 2323
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1811 VVIAVLMKHLEESNK 1825
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 1503 bits (3891), Expect = 0.0
Identities = 924/1764 (52%), Positives = 1100/1764 (62%), Gaps = 221/1764 (12%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1462
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562
Query: 1463 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1521
+AQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622
Query: 1522 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1581
CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682
Query: 1582 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1641
TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Query: 1642 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1701
G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801
Query: 1702 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1761
+ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858
Query: 1762 PRLPTGS----PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIK 1811
P P GS PG G PG P L+ D++SL+I+
Sbjct: 1859 PHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQ 1917
Query: 1812 DSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSIL 1867
SLE EL ++D L+G + P+ D Q + LAE EA SL S+ S S+
Sbjct: 1918 GSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ-IPLAEMEALSLTSEIVSEPSCSLA 1976
Query: 1868 LGDDLSLEDP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENF 1921
L DD SL D +A + EL P+ + V G +S T P+ +++
Sbjct: 1977 LTDD-SLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSY 2029
Query: 1922 LCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPE 1977
+C P+ R W K S P +S +L +P + H P
Sbjct: 2030 MCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPH 2083
Query: 1978 KGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSS 2023
GT+PK+ G RSP L RQA SLD + PS
Sbjct: 2084 SAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSP 2138
Query: 2024 SAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL---- 2069
+ S T + R+ + PPAP PGP P R L L
Sbjct: 2139 PLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTEL 2198
Query: 2070 -----------------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTH 2099
R L + A QR HS S G
Sbjct: 2199 SWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQP 2258
Query: 2100 HDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSS 2155
H DPS+ GG GG GS + LS S+T + P P PP+PG+ R+ S
Sbjct: 2259 HLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPS 2314
Query: 2156 TSSLAAPGRPHAAALAHGLARSPS 2179
+ S P A+ +A SPS
Sbjct: 2315 SDS----KDPLASGPPDSMAASPS 2334
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564
Query: 432 GDC 434
C
Sbjct: 1565 AQC 1567
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1822 VVIAVLMKHLEESNK 1836
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 1490 bits (3857), Expect = 0.0
Identities = 924/1787 (51%), Positives = 1100/1787 (61%), Gaps = 244/1787 (13%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622
Query: 1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1558
LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682
Query: 1559 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1618
VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742
Query: 1619 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802
Query: 1679 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1738
NWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859
Query: 1739 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1788
EA+E+AE++AELELEM L P P P GS PG G PG
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918
Query: 1789 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1848
P L+ D++SL+I+ SLE EL ++D L+G + P+ D Q +
Sbjct: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAGPGGQPSAFPSAPSLGGSDPQ-I 1976
Query: 1849 QLAETEAFSLN----SDRSSSILLGDDLSLEDP------TACPPGRKDSKGELDPPEPMR 1898
LAE EA SL S+ S S+ L DD SL D +A + EL P+ +
Sbjct: 1977 PLAEMEALSLTSEIVSEPSCSLALTDD-SLPDDMHTLLLSALESNMQPHPTELPGPDLLT 2035
Query: 1899 VGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDAS 1954
V G +S T P+ ++++C P+ R W K S P +
Sbjct: 2036 VRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADT 2089
Query: 1955 SPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSD 2014
S +L +P + H P GT+PK+ G RSP L RQA
Sbjct: 2090 SYILQLPKDAPH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRT 2138
Query: 2015 TSLD--------------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAP 2053
SLD + PS + S T + R+ + PPAP P
Sbjct: 2139 DSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCP 2198
Query: 2054 GPRAGLS---PAARRRLSL---------------------RGRGLFSLRGLRA------- 2082
GP P R L L R L + A
Sbjct: 2199 GPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRP 2258
Query: 2083 -----HQRSHSSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLF 2136
QR HS S G H DPS+ GG GG GS + LS S+T +
Sbjct: 2259 TSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-ID 2314
Query: 2137 CP----PPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2179
P P PP+PG+ R+ S+ S P A+ +A SPS
Sbjct: 2315 PPESQGPRTPPSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2357
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587
Query: 432 GDC 434
C
Sbjct: 1588 AQC 1590
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1845 VVIAVLMKHLEESNK 1859
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 1489 bits (3854), Expect = 0.0
Identities = 913/1743 (52%), Positives = 1085/1743 (62%), Gaps = 235/1743 (13%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1472
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
Query: 1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1532
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Query: 1533 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1652
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
Query: 1653 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1712
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGS---- 1768
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GS
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSPFLW 1858
Query: 1769 PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIID 1822
PG G PG P L+ D++SL+I+ SLE EL ++D
Sbjct: 1859 PGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMD 1917
Query: 1823 NLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPP 1882
L+G P G + AF S+ L G D P
Sbjct: 1918 ELAG--------PGG--------------QPSAFP-----SAPSLGGSD----------P 1940
Query: 1883 GRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPV--RSW--LK 1938
+ EL P+ + V G +S T P+ ++++C P+ R W K
Sbjct: 1941 QMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPK 1994
Query: 1939 HDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLR 1998
S P +S +L +P + H P GT+PK+ G R
Sbjct: 1995 AQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTIPKLPPPG-----R 2043
Query: 1999 SPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLEDSLTLSDSPRR 2044
SP L RQA SLD + PS + S T + R
Sbjct: 2044 SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSR 2103
Query: 2045 A-------LGPPAPAPGPRAGLS---PAARRRLSL---------------------RGRG 2073
+ + PPAP PGP P R L L R
Sbjct: 2104 SHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRD 2163
Query: 2074 LFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAG 2120
L + A QR HS S G H DPS+ GG GG G
Sbjct: 2164 LKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPG 2220
Query: 2121 SEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPHAAALAHGLAR 2176
S + LS S+T + P P PP+PG+ R+ S+ S P A+ +A
Sbjct: 2221 SRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPLASGPPDSMAA 2275
Query: 2177 SPS 2179
SPS
Sbjct: 2276 SPS 2278
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1811 VVIAVLMKHLEESNK 1825
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 1476 bits (3820), Expect = 0.0
Identities = 913/1766 (51%), Positives = 1085/1766 (61%), Gaps = 258/1766 (14%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRR-------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY
Sbjct: 1563 LEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHY 1622
Query: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569
QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLE
Sbjct: 1623 QQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLE 1682
Query: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629
EIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLL
Sbjct: 1683 EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLL 1742
Query: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689
FFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR
Sbjct: 1743 FFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR 1802
Query: 1690 DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1749
DC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AE
Sbjct: 1803 DC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859
Query: 1750 LELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGGLCRRCYSPAQE 1799
LELEM L P P P GS PG G PG P
Sbjct: 1860 LELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTDR 1918
Query: 1800 NLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN 1859
L+ D++SL+I+ SLE EL ++D L+G P G + AF
Sbjct: 1919 QLF-DTISLLIQGSLEWELKLMDELAG--------PGG--------------QPSAFP-- 1953
Query: 1860 SDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPE 1919
S+ L G D P + EL P+ + V G +S T P+ +
Sbjct: 1954 ---SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-D 1994
Query: 1920 NFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKG 1975
+++C P+ R W K S P +S +L +P + H
Sbjct: 1995 SYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQ 2048
Query: 1976 PEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASP 2021
P GT+PK+ G RSP L RQA SLD + P
Sbjct: 2049 PHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGP 2103
Query: 2022 SSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL-- 2069
S + S T + R+ + PPAP PGP P R L L
Sbjct: 2104 SPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDT 2163
Query: 2070 -------------------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGC 2097
R L + A QR HS S G
Sbjct: 2164 ELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGS 2223
Query: 2098 THHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKF 2153
H DPS+ GG GG GS + LS S+T + P P PP+PG+ R+
Sbjct: 2224 QPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRA 2279
Query: 2154 SSTSSLAAPGRPHAAALAHGLARSPS 2179
S+ S P A+ +A SPS
Sbjct: 2280 PSSDS----KDPLASGPPDSMAASPS 2301
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1659
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1660 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1719
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1528 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1555
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1774 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1833
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1834 VVIAVLMKHLEESNK 1848
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 1474 bits (3815), Expect = 0.0
Identities = 911/1756 (51%), Positives = 1080/1756 (61%), Gaps = 253/1756 (14%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1462
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562
Query: 1463 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1521
+AQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622
Query: 1522 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1581
CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682
Query: 1582 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1641
TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Query: 1642 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1701
G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801
Query: 1702 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1761
+ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858
Query: 1762 PRLPTGSPGA-PG-RGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELT 1819
P P GSP PG GP SP
Sbjct: 1859 PHSPLGSPFLWPGVEGPD-----------------SP----------------------- 1878
Query: 1820 IIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSLN----SDRSSSILLGDDLSLE 1875
D+ H + + + LAE EA SL S+ S S+ L DD SL
Sbjct: 1879 --DSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSLALTDD-SLP 1935
Query: 1876 DP------TACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIP 1929
D +A + EL P+ + V G +S T P+ ++++C
Sbjct: 1936 DDMHTLLLSALESNMQPHPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTA 1989
Query: 1930 FNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTL 1985
P+ R W K S P +S +L +P + H P GT+
Sbjct: 1990 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH------LLQPHSAPTWGTI 2043
Query: 1986 PKIALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTT 2031
PK+ G RSP L RQA SLD + PS +
Sbjct: 2044 PKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSF 2098
Query: 2032 LEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL------------ 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2099 WGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLL 2158
Query: 2070 ---------RGRGLFSLRGLRA------------HQRSHSSGGS-TSPGCTHHDSMDPSD 2107
R L + A QR HS S G H DPS+
Sbjct: 2159 PPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN 2218
Query: 2108 EEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPG 2163
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S
Sbjct: 2219 ---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----K 2270
Query: 2164 RPHAAALAHGLARSPS 2179
P A+ +A SPS
Sbjct: 2271 DPLASGPPDSMAASPS 2286
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564
Query: 432 GDC 434
C
Sbjct: 1565 AQC 1567
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1822 VVIAVLMKHLEESNK 1836
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 1471 bits (3809), Expect = 0.0
Identities = 913/1777 (51%), Positives = 1085/1777 (61%), Gaps = 269/1777 (15%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622
Query: 1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1558
LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682
Query: 1559 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1618
VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742
Query: 1619 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802
Query: 1679 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1738
NWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859
Query: 1739 EAQEDAEMDAELELEMAHGLGPGPRLPTGS----PGAPGRG------PGGAGGGGDTEGG 1788
EA+E+AE++AELELEM L P P P GS PG G PG
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSA 1918
Query: 1789 LCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEV 1848
P L+ D++SL+I+ SLE EL ++D L+G P G
Sbjct: 1919 SHFSLEHPTDRQLF-DTISLLIQGSLEWELKLMDELAG--------PGG----------- 1958
Query: 1849 QLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFP 1908
+ AF S+ L G D P + EL P+ + V G
Sbjct: 1959 ---QPSAFP-----SAPSLGGSD----------PQMQPHPTELPGPDLLTVRKSG----- 1995
Query: 1909 LSSTAVSPDPENFLCEMEEIPFNPV--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEF 1964
+S T P+ ++++C P+ R W K S P +S +L +P +
Sbjct: 1996 VSRTHSLPN-DSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDA 2054
Query: 1965 FHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLD------ 2018
H P GT+PK+ G RSP L RQA SLD
Sbjct: 2055 PH------LLQPHSAPTWGTIPKLPPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS 2103
Query: 2019 --------ASPSSSAGSLQTTLEDSLTLSDSPRRA-------LGPPAPAPGPRAGLS--- 2060
+ PS + S T + R+ + PPAP PGP
Sbjct: 2104 REDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGP 2163
Query: 2061 PAARRRLSL---------------------RGRGLFSLRGLRA------------HQRSH 2087
P R L L R L + A QR H
Sbjct: 2164 PETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRH 2223
Query: 2088 SSGGS-TSPGCTHHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPP 2142
S S G H DPS+ GG GG GS + LS S+T + P P P
Sbjct: 2224 SIAVSCLDSGSQPHLGTDPSN---LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTP 2279
Query: 2143 PAPGLTPARKFSSTSSLAAPGRPHAAALAHGLARSPS 2179
P+PG+ R+ S+ S P A+ +A SPS
Sbjct: 2280 PSPGICLRRRAPSSDS----KDPLASGPPDSMAASPS 2312
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587
Query: 432 GDC 434
C
Sbjct: 1588 AQC 1590
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1845 VVIAVLMKHLEESNK 1859
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 1469 bits (3804), Expect = 0.0
Identities = 798/1250 (63%), Positives = 927/1250 (74%), Gaps = 89/1250 (7%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLL 1479
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRRKAQ PYY+ Y RLL
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKPYYSDYSRFRLL 1562
Query: 1480 IHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLV 1539
+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLV
Sbjct: 1563 VHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLV 1622
Query: 1540 AFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLL 1599
AFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLL
Sbjct: 1623 AFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLL 1682
Query: 1600 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHA 1659
KMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHA
Sbjct: 1683 KMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHA 1742
Query: 1660 TFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQF 1719
TF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQF
Sbjct: 1743 TFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQF 1799
Query: 1720 VLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1769
VL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GSP
Sbjct: 1800 VLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1848
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1579 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1629
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1630 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1689
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1690 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1727
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 32/107 (29%), Positives = 57/107 (53%), Gaps = 14/107 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
++N+ + V+ F + +Q E R E+R R L + +P
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKP 1551
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1881 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1929
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1930 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1983
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 1984 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2038
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2039 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2098
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2099 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2155
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2156 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2210
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2211 ASGPPDSMAASPS 2223
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1744 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1803
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1804 VVIAVLMKHLEESNK 1818
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 1461 bits (3782), Expect = 0.0
Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1472
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
Query: 1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1532
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Query: 1533 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1652
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
Query: 1653 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1712
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1769
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GSP
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2045
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2046 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2105
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2106 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2162
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2163 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2217
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2218 ASGPPDSMAASPS 2230
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1811 VVIAVLMKHLEESNK 1825
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 1461 bits (3782), Expect = 0.0
Identities = 797/1257 (63%), Positives = 927/1257 (73%), Gaps = 96/1257 (7%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYAT 1472
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR +AQ PYY+
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSD 1562
Query: 1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVL 1532
Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK CNY+FT +FVL
Sbjct: 1563 YSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVL 1622
Query: 1533 EAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
E+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRI
Sbjct: 1623 ESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682
Query: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPC 1652
ARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG L C++ +PC
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPC 1742
Query: 1653 EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVS 1712
EG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C +++ +SP+YFVS
Sbjct: 1743 EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVS 1799
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1769
FVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P P P GSP
Sbjct: 1800 FVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQPHSPLGSP 1855
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1636
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1637 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1696
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1697 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1505 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1532
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.9 bits (89), Expect = 0.057
Identities = 84/315 (26%), Positives = 114/315 (36%), Gaps = 59/315 (18%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1888 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1936
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1937 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 1990
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGP 2048
G RSP L RQA SLD S + L + P
Sbjct: 1991 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGS--------REDLLAEEEP------ 2031
Query: 2049 PAPAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDE 2108
P PR + S + R L R H + S S G H DPS+
Sbjct: 2032 ----PSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS---GSQPHLGTDPSN- 2083
Query: 2109 EGRGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGR 2164
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S
Sbjct: 2084 --LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KD 2136
Query: 2165 PHAAALAHGLARSPS 2179
P A+ +A SPS
Sbjct: 2137 PLASGPPDSMAASPS 2151
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1810
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1811 VVIAVLMKHLEESNK 1825
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 1457 bits (3771), Expect = 0.0
Identities = 797/1268 (62%), Positives = 927/1268 (73%), Gaps = 107/1268 (8%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKL 903
ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S S+ D S + LD GD K
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEGDANKSESEPDFFSPS----------LDGDGDRKK 995
Query: 904 CPIPMTPNGH-------LDP----------SLPLGGHLGPAGAAGPAPRLSLQPDPMLVA 946
C ++ H L P SLP G A GPA R +
Sbjct: 996 CLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRT--------- 1046
Query: 947 LGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKPPS 1000
SS + +++ +S S+RSS + PW +++W SRRSS NSL K + PS
Sbjct: 1047 ----SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPS 1102
Query: 1001 AEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLD 1060
E SLLS E G ++ E +++E RA+P + H HR +L +
Sbjct: 1103 GERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH---------------RHRGSLERE 1144
Query: 1061 NRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGDRGDRGED-E 1119
+ S DL + + G H A+ R G A H+DCNG+ S + D G+D +
Sbjct: 1145 AKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGKSASGRLARALRPDDPPLDGDDAD 1202
Query: 1120 EEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAF 1179
+E + + RVR I P C R+ WS Y+F P++RFR+LC II HK+FD+VVL
Sbjct: 1203 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1262
Query: 1180 IFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSS 1239
IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+ EMT+KVV+LG FGEQAYLRSS
Sbjct: 1263 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1322
Query: 1240 WNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETL 1299
WNVLDG LV +S+IDI+VS+ S G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL
Sbjct: 1323 WNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETL 1382
Query: 1300 ISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHH 1359
+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C G DTRNITN+SDC A+YRWV H
Sbjct: 1383 MSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRH 1442
Query: 1360 KYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS 1419
KYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VDQQP+ NHNPWMLLYFISFLLIV+
Sbjct: 1443 KYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVA 1502
Query: 1420 FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR----------------- 1462
FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLEKKRR
Sbjct: 1503 FFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAA 1562
Query: 1463 -KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY 1521
+AQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+ ALK
Sbjct: 1563 SEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKI 1622
Query: 1522 CNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINP 1581
CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+LPINP
Sbjct: 1623 CNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINP 1682
Query: 1582 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1641
TIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELF
Sbjct: 1683 TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742
Query: 1642 GKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSS 1701
G L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E +C ++
Sbjct: 1743 GDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQESTCYNT 1801
Query: 1702 LQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPG 1761
+ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM L P
Sbjct: 1802 V--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-KTLSPQ 1858
Query: 1762 PRLPTGSP 1769
P P GSP
Sbjct: 1859 PHSPLGSP 1866
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 134 bits (337), Expect = 1e-30
Identities = 150/642 (23%), Positives = 275/642 (42%), Gaps = 122/642 (19%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQF--------SETK------------QREHRLML-------EQRQRYLSSSTVASYAEP 431
F SE++ R+ L L E R+ L + + A P
Sbjct: 965 EGFQAEGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1024
Query: 432 GDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHA---------- 481
+ + L A RR A + ++P A+ PH+
Sbjct: 1025 MSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEM--KSPPSARSSPHSPWSAASSWTS 1082
Query: 482 -KEPRHYHGKT----------------KGQGDEGRHLGSRHCQTLHGPASPGNDHSGREL 524
+ R+ G+ G+G E + + PA + H G
Sbjct: 1083 RRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLE 1142
Query: 525 CPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAG 584
S D P TL P AS S +H+D +G+ SG + A
Sbjct: 1143 REAKSSFD-LPDTLQVPGLHRTASGRGS--ASEHQD----------CNGKSASGRLARAL 1189
Query: 585 GEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWR------ETRAKL--RGI 636
D+ DG + ++G S+ + A L D W ++R +L I
Sbjct: 1190 RPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRI 1249
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHE-QPEELTNI-LEICNVVFTSMFALEMILKLAA- 693
+ K F+ +++ I +N +++ +E + P I L + N +FT++F EM +K+ A
Sbjct: 1250 ITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVAL 1309
Query: 694 ---FGLFDYLRNPYNIFDSIIVIISIWEIVGQ--ADGGLSVLRTFRLLRVLKLVRFMPAL 748
FG YLR+ +N+ D ++V+IS+ +I+ +D G +L R+LR+L+ +R + +
Sbjct: 1310 GWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVI 1369
Query: 749 RR----QLVV--LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL-----------R 791
R +LVV LM ++ + ++ F IF ILG+ +F KF + +
Sbjct: 1370 SRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNK 1429
Query: 792 TDTGDT----VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----------SPW 837
+D + V + NFD+L A++++F + +++ W ++Y+G+ + +PW
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGF------QAEGDANR 873
LYF++ + + + N+ V ++VE F Q E +A R
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1246 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1302
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1597 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1647
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1648 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1707
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1708 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1745
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1445 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1504
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1505 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1564
Query: 432 GDC 434
C
Sbjct: 1565 AQC 1567
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1899 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1947
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1948 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2001
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 2002 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2056
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2057 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2116
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2117 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2173
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2174 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2228
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2229 ASGPPDSMAASPS 2241
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1762 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1821
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1822 VVIAVLMKHLEESNK 1836
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 1456 bits (3770), Expect = 0.0
Identities = 798/1273 (62%), Positives = 927/1273 (72%), Gaps = 112/1273 (8%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLE 1516
LEKKRRKAQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY QP L+
Sbjct: 1563 LEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILD 1622
Query: 1517 TALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAA 1576
ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLEEIE+NA+
Sbjct: 1623 EALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1682
Query: 1577 LPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAAL 1636
LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AAL
Sbjct: 1683 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1742
Query: 1637 GVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDER 1696
GVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLRDC E
Sbjct: 1743 GVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC-DQES 1801
Query: 1697 SCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAH 1756
+C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AELELEM
Sbjct: 1802 TCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEM-K 1858
Query: 1757 GLGPGPRLPTGSP 1769
L P P P GSP
Sbjct: 1859 TLSPQPHSPLGSP 1871
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1602 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1652
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1653 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1712
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1713 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1750
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 32/107 (29%), Positives = 57/107 (53%), Gaps = 14/107 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431
++N+ + V+ F + +Q E R E+R R L + +P
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRKAQCKP 1574
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1904 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1952
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1953 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2006
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 2007 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2061
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2062 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2121
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2122 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2178
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2179 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2233
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2234 ASGPPDSMAASPS 2246
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1767 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1826
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1827 VVIAVLMKHLEESNK 1841
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 1448 bits (3748), Expect = 0.0
Identities = 797/1280 (62%), Positives = 927/1280 (72%), Gaps = 119/1280 (9%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRR-------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I LNVVTM++EHY
Sbjct: 1563 LEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHY 1622
Query: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569
QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAIVLLS+MGITLE
Sbjct: 1623 QQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLE 1682
Query: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629
EIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLL
Sbjct: 1683 EIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLL 1742
Query: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689
FFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR
Sbjct: 1743 FFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR 1802
Query: 1690 DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAE 1749
DC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNKEA+E+AE++AE
Sbjct: 1803 DC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAE 1859
Query: 1750 LELEMAHGLGPGPRLPTGSP 1769
LELEM L P P P GSP
Sbjct: 1860 LELEM-KTLSPQPHSPLGSP 1878
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1659
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1660 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1719
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1720 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.5 bits (132), Expect = 6e-07
Identities = 30/90 (33%), Positives = 53/90 (58%), Gaps = 12/90 (13%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQFSETKQREHRLMLEQRQR 418
++N+ + V+ F K R+H+ E R+R
Sbjct: 1528 VLNMFVGVVVENFH--KCRQHQEEEEARRR 1555
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1911 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1959
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1960 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2013
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 2014 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2068
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2069 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2128
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2129 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2185
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2186 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2240
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2241 ASGPPDSMAASPS 2253
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1774 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1833
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1834 VVIAVLMKHLEESNK 1848
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 1444 bits (3737), Expect = 0.0
Identities = 797/1291 (61%), Positives = 927/1291 (71%), Gaps = 130/1291 (10%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVD 1396
G DTRNITN+SDC A+YRWV HKYNFDNLGQALMSLFVLASKDGWV+IMY+GLDAV VD
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVD 1502
Query: 1397 QQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRR 1456
QQP+ NHNPWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRR
Sbjct: 1503 QQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRR 1562
Query: 1457 LEKKRR------------------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1498
LEKKRR +AQ PYY+ Y RLL+H +CTSHYLD+FIT +I
Sbjct: 1563 LEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIG 1622
Query: 1499 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1558
LNVVTM++EHY QP L+ ALK CNY+FT +FVLE+V KLVAFG RRFF+DRWNQLDLAI
Sbjct: 1623 LNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAI 1682
Query: 1559 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1618
VLLS+MGITLEEIE+NA+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQ
Sbjct: 1683 VLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQ 1742
Query: 1619 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
VGNLGLLFMLLFFI+AALGVELFG L C++ +PCEG+ RHATF NFGMAFLTLF+VSTGD
Sbjct: 1743 VGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD 1802
Query: 1679 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1738
NWNGIMKDTLRDC E +C +++ +SP+YFVSFVLTAQFVL+NVV+AVLMKHL++SNK
Sbjct: 1803 NWNGIMKDTLRDC-DQESTCYNTV--ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNK 1859
Query: 1739 EAQEDAEMDAELELEMAHGLGPGPRLPTGSP 1769
EA+E+AE++AELELEM L P P P GSP
Sbjct: 1860 EAKEEAELEAELELEM-KTLSPQPHSPLGSP 1889
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 76.3 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 83/158 (52%), Gaps = 20/158 (12%)
Query: 88 VILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCY 145
VI LN VT+ M YQ +D + L++ + + F +E V K+VA FG + +
Sbjct: 1620 VIGLNVVTMAMEHYQQPQILD------EALKICNYIFTVIFVLESVFKLVA---FGFRRF 1670
Query: 146 LGDTWNRLDFFIVMAGMVEYSLDLQNINLSA---------IRTVRVLRPLKAINRVPSMR 196
D WN+LD IV+ ++ +L+ +N S +R +R+ R LK + MR
Sbjct: 1671 FQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMR 1730
Query: 197 ILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGL 234
L++ ++ LP +GN+ LL +FFIF +GV+L+ L
Sbjct: 1731 ALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1768
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 55.8 bits (133), Expect = 4e-07
Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 27/123 (21%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSFF 388
NFDN+G A + +F + + +GWV+IMY +DA H+ + +YFI +++ +FF
Sbjct: 1468 NFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF 1527
Query: 389 MINLCLVVIATQF---------SETKQREHRLM--LEQRQRYL------SSSTVASYAEP 431
++N+ + V+ F E ++RE + + LE+++R L +S + AS A
Sbjct: 1528 VLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASE 1587
Query: 432 GDC 434
C
Sbjct: 1588 AQC 1590
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 39.3 bits (90), Expect = 0.044
Identities = 95/373 (25%), Positives = 126/373 (33%), Gaps = 96/373 (25%)
Query: 1873 SLEDPTACPPGRKDSKGELDPPEPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNP 1932
SLE PT P EL P+ + V G +S T P+ ++++C P
Sbjct: 1922 SLEHPTMQP-----HPTELPGPDLLTVRKSG-----VSRTHSLPN-DSYMCRHGSTAEGP 1970
Query: 1933 V--RSW--LKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKI 1988
+ R W K S P +S +L +P + H P GT+PK+
Sbjct: 1971 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQ------PHSAPTWGTIPKL 2024
Query: 1989 ALQGSWASLRSPRVNCTLLRQATGSDTSLD--------------ASPSSSAGSLQTTLED 2034
G RSP L RQA SLD + PS +
Sbjct: 2025 PPPG-----RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGPSPPLARAYSFWGQ 2079
Query: 2035 SLTLSDSPRRA-------LGPPAPAPGPRAGLS---PAARRRLSL--------------- 2069
S T + R+ + PPAP PGP P R L L
Sbjct: 2080 SSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLPPG 2139
Query: 2070 ------RGRGLFSLRGLRAH------------QRSHSSGGST-SPGCTHHDSMDPSDEEG 2110
R L + A QR HS S G H DPS+
Sbjct: 2140 GQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSN--- 2196
Query: 2111 RGGAGGGGAGSEHSETLSSLSLTSLFCP----PPPPPAPGLTPARKFSSTSSLAAPGRPH 2166
GG GG GS + LS S+T + P P PP+PG+ R+ S+ S P
Sbjct: 2197 LGGQPLGGPGSRPKKKLSPPSIT-IDPPESQGPRTPPSPGICLRRRAPSSDS----KDPL 2251
Query: 2167 AAALAHGLARSPS 2179
A+ +A SPS
Sbjct: 2252 ASGPPDSMAASPS 2264
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
Score = 34.7 bits (78), Expect = 1.1
Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 8/75 (10%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVM----DAHSFYNF----IYFILLIIVGSFFMIN 391
F N G A++ +F+V T + W IM + + YN IYF+ ++ F ++N
Sbjct: 1785 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVN 1844
Query: 392 LCLVVIATQFSETKQ 406
+ + V+ E+ +
Sbjct: 1845 VVIAVLMKHLEESNK 1859
>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
Length = 1555
Score = 818 bits (2114), Expect = 0.0
Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)
Query: 547 ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603
A P SCP C +G G + + +E S S A E +A R
Sbjct: 661 ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
Query: 604 ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663
LG + E WR R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 715 SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
Query: 664 QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723
QPEELTN LEI N+VFTS+FALEM+LKL +G F Y++NPYNIFD +IV+IS+WEIVGQ
Sbjct: 767 QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
Query: 724 DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783
GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 827 GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
Query: 784 FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843
FGCKF+ D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 887 FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880
ALMTFGNYVLFNLLVAILVEGFQAE GDAN+S S+ D
Sbjct: 946 ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
Query: 881 SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923
S + LD GD K C ++ H L P SLP
Sbjct: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
Query: 924 LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983
G A GPA R + SS + +++ +S S+RSS + PW +++
Sbjct: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
Query: 984 WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037
W SRRSS NSL K + PS E SLLS E G ++ E +++E RA+P + H
Sbjct: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
Query: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097
HR +L + + S DL + + G H A+ R G A H+DCNG+
Sbjct: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
Query: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156
S + D G+D ++E + + RVR I P C R+ WS Y+F P+
Sbjct: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
Query: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216
+RFR+LC II HK+FD+VVL IFLNCITIA+ERP+I+ S ERIFLT+SNYIFTA+F+
Sbjct: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
Query: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276
EMT+KVV+LG FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S G KILG+LRVLRL
Sbjct: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
Query: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336
LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C
Sbjct: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
Query: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1368
G DTRNITN+SDC A+YRWV HKYNFDNLGQ
Sbjct: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
Score = 607 bits (1564), Expect = e-173
Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)
Query: 25 QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84
+PGP S P + +G +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 31 RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
Query: 85 SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144
SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 87 SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
Query: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204
YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
Query: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264
TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++ V L YYQ E +DE
Sbjct: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
Query: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321
PFICS +NG+ C +P L+ G C L D+ A N + CVNWN+
Sbjct: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
Query: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381
YY C G NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
Query: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440
IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
Query: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472
Y+ +ILRKA RR + +A R L AP
Sbjct: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
Score = 119 bits (298), Expect = 3e-26
Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)
Query: 1432 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1491
E ++ Q + + R +R R L + L ++ C T + S Y
Sbjct: 691 EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747
Query: 1492 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1551
I I +N ++M +E++ QP L AL+ N +FT++F LE +LKL+ +G + K+ +
Sbjct: 748 GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807
Query: 1552 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1611
N D IV++SV I ++ + ++R R+ RVLKL++ ++ L
Sbjct: 808 NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
Query: 1612 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1671
+++ + V +L ML FI++ LG+ LFG + E + + F++ A +T+
Sbjct: 858 LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916
Query: 1672 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1731
FQ+ T ++WN ++ + ++S + LYF++ + +VL N++VA+L++
Sbjct: 917 FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965
Query: 1732 HLDDSNKEAQEDA 1744
+EDA
Sbjct: 966 GFQAEEISKREDA 978
Score = 114 bits (285), Expect = 1e-24
Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)
Query: 1159 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1215
+R++C T I+ K F ++ I +N +++ +E + T L +SN +FT++F
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786
Query: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
EM LK+ L +G Y+++ +N+ DG +V +S+ +IV GG L VLR R
Sbjct: 787 ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837
Query: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
L+R L+ +R + P L+ + L+ ++ + ++ F IF ILG+ LF KF
Sbjct: 838 LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
Query: 1336 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1395
DT + + NFD+L A++++F + +++ W ++YNG+
Sbjct: 895 RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933
Query: 1396 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451
+ + W LYFI+ + ++ + N+ V ++VE F +AEE +RE+
Sbjct: 934 -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
Score = 112 bits (279), Expect = 5e-24
Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)
Query: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207
+ S ++R R C + + F+ + + I LNC+T+ + RP I S RI
Sbjct: 62 FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
Query: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267
++IF A F EM +K+V+LG+ FG++ YL +WN LD F+V +++ + L + + +
Sbjct: 122 DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
Query: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327
R +R LRPLR I+R P ++++V L+ +L +GN++L+C F IFGI+GVQL
Sbjct: 180 -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
Query: 1328 FKG 1330
+ G
Sbjct: 233 WAG 235
Score = 103 bits (257), Expect = 2e-21
Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)
Query: 72 CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130
C +++ + F+ V +++I LNC+T+ M +P D +I ++IF F EM
Sbjct: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
Query: 131 VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182
+K+VALG FG++ YL +WN LD +V+ +++ + + + + L +R +R
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
Query: 183 LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
LRPL+ I+R ++++V L+ +L +GN++++C F IFGI+GVQL+ G
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
Score = 96.7 bits (239), Expect = 2e-19
Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)
Query: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1534
RLL H + T D + II LN +T+++E P S E L NY+FT VF+ E
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
Query: 1535 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1590
+K+VA FG + + + WN LD +VL+SV+ I + + + + ++R++R+L
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383
Query: 1591 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1648
R R L+++ A G++ +++T++ +L +GN+ ++ F I+ LGV+LF GK VC
Sbjct: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443
Query: 1649 EN 1650
E+
Sbjct: 1444 ED 1445
Score = 71.2 bits (173), Expect = 1e-11
Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)
Query: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626
+G E SG S ++ G G R A + G + E E V+
Sbjct: 8 AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
Query: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682
R+ V + +F R M+ IL+N V++G+ E + IL+ + +
Sbjct: 68 SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
Query: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738
FA+EM++K+ A G+F YL + +N D IVI + E + + S +RT R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784
L+ + +P++R + +L+ T+ + +L FIF I+G+ ++
Sbjct: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
Score = 65.5 bits (158), Expect = 6e-10
Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)
Query: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548
+I LN VT+ + + + ++ L+ + F +E V+K+VA FG + +
Sbjct: 90 VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
Query: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608
D WN+LD IV+ ++ +L+ ++ + +R +R+ R L+ + MR L
Sbjct: 150 DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
Query: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647
+ ++ LP +GN+ LL +FFI+ +GV+L+ L+ N
Sbjct: 201 VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)
Query: 74 KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130
K+V + +F M+ IL+N +++G+ QP + L++ + FA+EM
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
Query: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190
+LK++ G FG Y+ + +N D IV+ + E + Q LS +RT R++R LK +
Sbjct: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
+P+++ + +L+ T+ + +L FIF I+G+ L+
Sbjct: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
Score = 60.5 bits (145), Expect = 2e-08
Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
++C A + NFDN+G A +++F + + +GWV+IMY +DA H+ +
Sbjct: 321 TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457
+YFI +++ SFF++N+ + V+ F + +Q E++ E+R+R L
Sbjct: 371 NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398
NFD++ +A + +FQ++T E W +++Y M + S + +YFI L+ G++ + NL + ++
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
Query: 399 TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451
F Q E E LS + ++ GD E + L RK
Sbjct: 965 EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
Query: 452 RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511
+ L + + R+ L P A P + G + G R S G
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
Query: 512 PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569
A PG H SP A +PH+ P + AS S ++ GR PS
Sbjct: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
Query: 570 TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608
+ SG+ S GE + D SSE+ +S G +
Sbjct: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
Score = 46.6 bits (109), Expect = 3e-04
Identities = 19/63 (30%), Positives = 39/63 (61%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
NFD++ +A + +FQ++T E W ++Y M + S + +YF+ L+ G++ + NL + ++
Sbjct: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
Query: 863 EGF 865
F
Sbjct: 396 TQF 398
Score = 38.1 bits (87), Expect = 0.097
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
+ NP +G F+N G A++ +FQV T + W IM + + F +
Sbjct: 327 EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
+YF+ ++ F +IN+ + V+ ++ + +
Sbjct: 373 IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 523 bits (1347), Expect = e-148
Identities = 450/1769 (25%), Positives = 768/1769 (43%), Gaps = 239/1769 (13%)
Query: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAM 128
R IK+ + WF + IL+NCV C++ R + + + + +
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCV------------CMT-RTDLPEKIEYVFTVIYTF 166
Query: 129 EMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLK 187
E ++K++A G + YL D WN LDF ++ V ++DL+ I S +RT RVLR LK
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGI--SGLRTFRVLRALK 224
Query: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEE---- 243
++ +P ++++V L+ ++ L +V +L F +F ++G+QL+ G L+N+C +
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284
Query: 244 NFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDF 303
T P Y + P +C D+G C D Y
Sbjct: 285 ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSG---------------HC----PDGY-- 323
Query: 304 GAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIM 363
+C S NP +FD+ +A++ +F+++T + W +
Sbjct: 324 ---------------------ICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY 362
Query: 364 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSS 423
+ I+F+L+I +GSF+++NL L V+ + E Q
Sbjct: 363 QQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQ----------------- 405
Query: 424 TVASYAEPGDCYEEIFQYVCHILRKAKR--RALGL-YQALQSRRQALGPEAPAPAKPGPH 480
+ + + E+ FQ +LRK + ALG+ +L S + P A H
Sbjct: 406 ---ATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGS--PLTSKNASERRH 460
Query: 481 AKEPRHYHGKTKGQGDEGRH-----------LGSRHCQTLHGPA----SPGNDHSGRELC 525
+PR G T+ L S + HG SPG D S E
Sbjct: 461 RIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGV 520
Query: 526 PQHS--PLDATPHT----------LVQPIPATLASDPASCPCCQHEDGRRPSGL-----G 568
P D H P+P + P++ ED +P G
Sbjct: 521 TDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPG 580
Query: 569 STDSGQEGSGSGSSAGGEDEAD----GDGARSSEDGASSELGKEEEEEEQADGA------ 618
+ D +G + + D A S +S L + EE E++
Sbjct: 581 AVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQ 640
Query: 619 ---VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 675
+W C +W + + L G+V + I + I+VNT+ M +EHH +L+I
Sbjct: 641 KYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIG 700
Query: 676 NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRL 735
N+VFT F EM+ K+ AF + Y + +NIFD IIV +S+ E+ G LSVLR+FRL
Sbjct: 701 NIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRL 760
Query: 736 LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF-SLRTDT 794
LRV KL + P L + ++ ++ + ++L + +F+F+++G + G + + R +
Sbjct: 761 LRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNI 820
Query: 795 GDTVPD--RKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNY 851
D R + + + VF+IL E W ++ M + F+ +M GN
Sbjct: 821 SAPHEDWPRWHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGNL 879
Query: 852 VLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPN 911
V+ NL +A+L+ F A+ N + ++D +N++ + LC
Sbjct: 880 VVLNLFIALLLNSFSAD---NLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSF----- 931
Query: 912 GHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSR 971
S P P P+ +P LV SS + R S
Sbjct: 932 --FSRSCPF-----------PQPKA----EPELVVKLPLSSSKAENHIAANTARGSSGGL 974
Query: 972 SSYYGPWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAP 1031
+ GP + + + + W S+ P AE ES L G + E P+
Sbjct: 975 QAPRGPRDEHSDFIANPTVWVSV----PIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQ 1030
Query: 1032 LHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGH 1091
G HL R S DLA P++G + PA G
Sbjct: 1031 EQLQQVERC--GDHLTPRSPG-------TGTSSEDLA---PSLGETWKDESVPQVPAEGV 1078
Query: 1092 EDCNGRMPSIA-----KDVFTKMGDRGDRGEDEEEIDYTLCFRVRKM--IDVYKPDWCEV 1144
+D + S +++ K+ + D E+ ++ C R +D K W
Sbjct: 1079 DDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPW--- 1135
Query: 1145 REDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1204
W V R C I+ H F+ ++ I L+ ++A E ++ T + L
Sbjct: 1136 DVGWQV---------RKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALL 1186
Query: 1205 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGG 1264
++ +FT IFV EM LK V+ +G + Y ++W LD +V +S+I + +
Sbjct: 1187 EYTDRVFTFIFVFEMLLKWVA----YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSE 1242
Query: 1265 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1324
+ ++ LR LR LRPLR +SR G+++VV+ L+ ++ I N++L+C F++IF I+G
Sbjct: 1243 ---VAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
Query: 1325 VQLFKGKFYHCLG--------VDTRNITNRSDCMAAN----YRWVHHKYNFDNLGQALMS 1372
V LF GKF+ C+ V + N+SDC N + WV+ K NFDN+ ++
Sbjct: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359
Query: 1373 LFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVE 1432
L +A+ GW++IMY +D+ V+ QP N +M LYF+ F++ FF LN+FVGV+++
Sbjct: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419
Query: 1433 NFHKCRQHQEAEEARRREE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLD 1490
NF++ ++ ++ EE K ++K K + P + + + T D
Sbjct: 1420 NFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFD 1479
Query: 1491 IFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKD 1549
I I +ICLN++TM +E +Q L N F VF E V+K+ F LR+ +F +
Sbjct: 1480 ITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKM--FALRQYYFTN 1537
Query: 1550 RWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALL 1609
WN D +V+LS+ + I + +PT+ R++R+ RI R+L+L++ A G+R LL
Sbjct: 1538 GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597
Query: 1610 DTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFL 1669
++ +LP + N+GLL L+ FIY+ G+ F + G+ F+ F + L
Sbjct: 1598 FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSML 1652
Query: 1670 TLFQVSTGDNWNGIMKDTLR-----------DCTHDERSCLSSLQFVSPLYFVSFVLTAQ 1718
LFQ++T W+G++ L + C S V ++F ++++ +
Sbjct: 1653 CLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPA--VGIIFFTTYIIISF 1710
Query: 1719 FVLINVVVAVLMKHLDDSNKEAQEDAEMD 1747
+++N+ +AV++++ + + +E+ E D
Sbjct: 1711 LIMVNMYIAVILENFNVATEESTEPLSED 1739
Score = 108 bits (270), Expect = 6e-23
Identities = 85/355 (23%), Positives = 153/355 (43%), Gaps = 68/355 (19%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
+++LFSP N R + H F + I +NC+ + E+I
Sbjct: 109 ALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT------RTDLPEKI-----E 157
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y+FT I+ E +K+++ G E YLR WN LD ++ ++ + + L G
Sbjct: 158 YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---- 213
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
LR R LR L+ +S PGLK++V LI S+K + ++ ++ +F ++G+QLF
Sbjct: 214 -----LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268
Query: 1329 KGKFYH-CLGVD-----TRNIT---------------------NRSD---------CMAA 1352
KG + C+ D T N + N SD C+
Sbjct: 269 KGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKT 328
Query: 1353 NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFI 1412
+ + +FD+ A +SLF L ++D W + QQ + +++F+
Sbjct: 329 SDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFV 378
Query: 1413 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRL 1467
+ + SF+++N+ + VV + + Q+Q + +EK+ + + RK Q +
Sbjct: 379 LVIFLGSFYLVNLILAVVTMAYEE--QNQATTDEIEAKEKKFQEALEMLRKEQEV 431
Score = 98.2 bits (243), Expect = 8e-20
Identities = 73/285 (25%), Positives = 133/285 (46%), Gaps = 36/285 (12%)
Query: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
IV + F+ IM+ I +N ++M +E +Q EE T IL N F ++F E ++K+ A
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR 1531
Query: 696 LFDYLRNPYNIFDSIIVIISIWEIVGQA----------DGGLSVLRTFRLLRVLKLVRFM 745
+ Y N +N+FD I+V++SI ++ A V+R R+ R+L+L+R
Sbjct: 1532 QY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAA 1590
Query: 746 PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
+R L LM ++ + +LL L +FI+SI GM F +R + G + D NF
Sbjct: 1591 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFP---HVRWEAG--IDDMFNFQ 1645
Query: 806 SLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS--------------------LYFVAL 845
+ +++ +FQI T W+ +L + + P+ ++F
Sbjct: 1646 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTY 1705
Query: 846 MTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
+ ++ N+ +A+++E F + + ED E ++K
Sbjct: 1706 IIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEK 1750
Score = 97.8 bits (242), Expect = 1e-19
Identities = 79/245 (32%), Positives = 117/245 (47%), Gaps = 39/245 (15%)
Query: 29 RSPPSSPPGLEEPLD----GADPHVPHPDLAPIAFFCLRQTTSPRNW---------CIKM 75
R P LEEP D G H P C + T+ W C ++
Sbjct: 1099 RKIPELADDLEEPDDCFTEGCIRHCP----------CCKLDTTKSPWDVGWQVRKTCYRI 1148
Query: 76 VCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAMEMVLKM 134
V + WFE + +ILL+ +L D K L + D +F F F EM+LK
Sbjct: 1149 VEHSWFESFIIFMILLSSGSLAFEDYYLDQ---KPTVKALLEYTDRVFTFIFVFEMLLKW 1205
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRPLKAIN 190
VA +G K Y + W LDF IV ++ + + + + A+RT+R LRPL+A++
Sbjct: 1206 VA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALS 1262
Query: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGD 250
R MR++V+ L+ +P + NVLL+C + IF I+GV L+AG RC N+T G+
Sbjct: 1263 RFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW-RCI---NYT-DGE 1317
Query: 251 VALPP 255
+L P
Sbjct: 1318 FSLVP 1322
Score = 94.7 bits (234), Expect = 9e-19
Identities = 75/319 (23%), Positives = 147/319 (46%), Gaps = 29/319 (9%)
Query: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500
+E EE+ ++ L L +K P + + ++ + T + ++ IT I +N
Sbjct: 622 EELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL---KTILFGLVTDPFAELTITLCIVVN 678
Query: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560
+ M++EH+ + E L+ N +FT F E V K++AF +F+ +WN D IV
Sbjct: 679 TIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVT 738
Query: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620
+S+ +E+ A + ++R R+ RV KL K + L+ + ++ +G
Sbjct: 739 VSL-------LELGVA---KKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALG 788
Query: 1621 NLGLLFMLLFFIYAALGVELFGKLVCNDEN----PCEGMSRHATFENFGMAFLTLFQVST 1676
NL ++ ++ F++A +G +L G+ N+ P E R +F +FL +F++
Sbjct: 789 NLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRW-HMHDFFHSFLIVFRILC 847
Query: 1677 GDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
G+ W M + + CL + F++ ++ V++N+ +A+L+
Sbjct: 848 GE-WIENMWACME--VGQKSICL--------ILFLTVMVLGNLVVLNLFIALLLNSFSAD 896
Query: 1737 NKEAQEDAEMDAELELEMA 1755
N A ED L++ +A
Sbjct: 897 NLTAPEDDGEVNNLQVALA 915
Score = 84.0 bits (206), Expect = 2e-15
Identities = 81/339 (23%), Positives = 149/339 (43%), Gaps = 78/339 (23%)
Query: 615 ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 674
A A+WL R ++ V S +F+ I + ILVN V M T++ E
Sbjct: 106 ATRALWLFSPFNLIRRTAIKVSVHS-WFSLFITVTILVNCVCM---------TRTDLPEK 155
Query: 675 CNVVFTSMFALEMILKLAAFGL----FDYLRNPYNIFDSIIVIISIWEIVGQADG--GLS 728
VFT ++ E ++K+ A G F YLR+P+N D ++ ++ VG A G+S
Sbjct: 156 IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAY---VGTAIDLRGIS 212
Query: 729 VLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF 788
LRTFR+LR LK V +P L+ + L+ ++ +A +L + + +F+++G+ +F
Sbjct: 213 GLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272
Query: 789 SLRTDTGDTV------------PD-----RKNFDSLL----------------------- 808
+ D PD R D LL
Sbjct: 273 KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332
Query: 809 -----------WAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLL 857
WA +++F+++TQ+ W + + ++ ++FV ++ G++ L NL+
Sbjct: 333 DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLI 392
Query: 858 VAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLD 896
+A++ ++ + N++ +DE ++ K QE L+
Sbjct: 393 LAVVTMAYE---EQNQATTDEIEAKEK-----KFQEALE 423
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 354 bits (908), Expect = 6e-97
Identities = 196/594 (32%), Positives = 337/594 (56%), Gaps = 34/594 (5%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C I+ H F+ ++ I L+ + E +E + L ++ IFT IF+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ G FG+ Y S+W LD +V VS+ ++ + L+ R LR
Sbjct: 1106 VLKWVAFG--FGK--YFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
LRPLR +S+ G+K+VV LI ++ I N++L+C F+++F ILGV F GKF C+
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211
Query: 1338 ---VDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
++ ITN+S C + N+ W++ K NFDN+G A ++L +A+ GW++I+Y +D+
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271
Query: 1395 VDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--K 1452
+QQP N +YF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE K
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331
Query: 1453 RLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQP 1512
++K K + P + L+ + TS DI I +I LN+++M E YNQP
Sbjct: 1332 YYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQP 1391
Query: 1513 TSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR-FFKDRWNQLDLAIVLLSVMGITLEEI 1571
++++ L + N++F +F LE ++K+ F LR+ +F + WN D +VLLS++ + +
Sbjct: 1392 KAMKSILDHLNWVFVVIFTLECLIKI--FALRQYYFTNGWNLFDCVVVLLSIVSTMISTL 1449
Query: 1572 EINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF 1631
E +P PT+ RI+R+ RI R+L+L++ A G+R LL ++ +LP + N+GLL L+ F
Sbjct: 1450 ENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMF 1509
Query: 1632 IYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR-- 1689
IYA LG+ F K+ NP G+ F+ F + L LFQ+ST W+ ++ LR
Sbjct: 1510 IYAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSK 1564
Query: 1690 -DCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742
C +C L ++ YFVS+++ + +++N+ +AV++++ + + +E+++
Sbjct: 1565 ESCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616
Score = 130 bits (328), Expect = 1e-29
Identities = 81/263 (30%), Positives = 137/263 (52%), Gaps = 14/263 (5%)
Query: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
VW C W + LR ++ + I + I++NTV + +EHH+ +L I N+V
Sbjct: 556 VWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLV 615
Query: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG--QADGGLSVLRTFRLL 736
FTS+F EM LK+ A + Y R +NIFDSI+ ++S +++ LR+FR+L
Sbjct: 616 FTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVL 675
Query: 737 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS------L 790
RV KL + P L + ++ ++ + + ++L++ IFIFS++GM +FG F+ L
Sbjct: 676 RVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKL 735
Query: 791 RTDTGDTVPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL---YFVAL 845
TG TV +++ + + VF+IL E W ++ M + +SL F+ +
Sbjct: 736 CNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILI 794
Query: 846 MTFGNYVLFNLLVAILVEGFQAE 868
G V+ NL +A+L+ F E
Sbjct: 795 TVIGKLVVLNLFIALLLNSFSNE 817
Score = 119 bits (299), Expect = 3e-26
Identities = 84/349 (24%), Positives = 165/349 (47%), Gaps = 55/349 (15%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++++F P N R L + H LF ++ + +NC+ +A P + S ++
Sbjct: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
+FT I++ E +K+++ G E ++LR WN LD ++ ++I+ + + K+L
Sbjct: 164 CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
LR R+ R L+ + V+SR LK++V L+ S+K + N++++ IF ++G QLF
Sbjct: 220 P-LRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275
Query: 1329 KGKF-YHCLGVDTRNITN------------------------RSDCMAANYRWVHHKY-- 1361
G C+ D +NI+N + + Y H K
Sbjct: 276 MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335
Query: 1362 -----NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLL 1416
NFDN G + +++F L ++D W + QQ + + + +FI +
Sbjct: 336 DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385
Query: 1417 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLEKKRRKA 1464
+ SF+++N+ + VV + + ++ AE EA+ + + ++L K+ ++A
Sbjct: 386 LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEA 434
Score = 116 bits (291), Expect = 2e-25
Identities = 87/347 (25%), Positives = 156/347 (44%), Gaps = 50/347 (14%)
Query: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
A F S R+ I++ + F + +++NCV + P + + S+ I +
Sbjct: 108 ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKNSN--SNNTDIAEC 164
Query: 118 FDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
I+IF E ++K++A G I + +L D WN LD ++ +V Y + I L
Sbjct: 165 VFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGI-TIKLLP 220
Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+RT RV R LKAI+ V ++++V LL ++ L NV++L FF IF ++G QL+ G L
Sbjct: 221 LRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLN 280
Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
+C + I A ++ +E+ +C + N C +
Sbjct: 281 LKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNS---------------ACSIQ 325
Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITL 356
+ C+ NP NFDN G++++ +F+++T
Sbjct: 326 YE---------------------------CKHTKINPDYNYTNFDNFGWSFLAMFRLMTQ 358
Query: 357 EGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 403
+ W ++ + Y+ +FI++I +GSF++INL L V+ + E
Sbjct: 359 DSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405
Score = 105 bits (262), Expect = 5e-22
Identities = 69/281 (24%), Positives = 138/281 (49%), Gaps = 33/281 (11%)
Query: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538
++ ++ T + ++ IT I +N V +++EH+ S E L N +FT++F+ E LK+
Sbjct: 569 VLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 628
Query: 1539 VAFGLRRFFKDRWNQLDLAIVLLS---VMGITLEEIEINAALPINPTIIRIMRVLRIARV 1595
+A +F+ WN D + LLS VM L++ + P +R R+ RV
Sbjct: 629 IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQK----RSWP-------FLRSFRVLRV 677
Query: 1596 LKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK--------LVCN 1647
KL K + L+ + ++ +G+L ++ +++ FI++ +G++LFG+ +CN
Sbjct: 678 FKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCN 737
Query: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707
P RH +F +FL +F++ G+ W M + +++ C+
Sbjct: 738 PTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV-------- 788
Query: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDA 1748
+ F+ + + V++N+ +A+L+ SN+E + E +A
Sbjct: 789 IVFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827
Score = 103 bits (258), Expect = 1e-21
Identities = 74/277 (26%), Positives = 137/277 (49%), Gaps = 28/277 (10%)
Query: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
IV S+ F+ I+ I++N +SM E + QP+ + +IL+ N VF +F LE ++K+ A
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421
Query: 696 LFDYLRNPYNIFDSIIVIISI----------WEIVGQADGGLSVLRTFRLLRVLKLVRFM 745
+ Y N +N+FD ++V++SI E + ++R R+ R+L+LVR
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480
Query: 746 PALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
+R L LM ++ ++ +LL L +FI++ILGM+ F + + + D NF
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535
Query: 806 SLLWAIVTVFQILTQEDWNVVLYNGMASTSPW------------ASLYFVALMTFGNYVL 853
+ +++ +FQI T W+ +L + S A+ YFV+ + ++
Sbjct: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595
Query: 854 FNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
N+ +A+++E F + + ED E ++K
Sbjct: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEK 1632
Score = 99.0 bits (245), Expect = 5e-20
Identities = 69/279 (24%), Positives = 129/279 (46%), Gaps = 40/279 (14%)
Query: 625 VWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSM 682
+W R IV +F I+ IL+++ ++ E H E ++ +L +++FT +
Sbjct: 1041 IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHI 1100
Query: 683 FALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV 742
F LEM+LK AFG Y + + D IIVI+S+ ++ L L++FR LR L+ +
Sbjct: 1101 FILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRTLRALRPL 1155
Query: 743 RFMPALRRQLVV---LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTV- 798
R + VV L+ + + ++ ++F +F ILG++ F KF + D+V
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGTDSVI 1215
Query: 799 -------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAST----- 834
+ NFD++ A + + Q+ T + W ++Y + ST
Sbjct: 1216 NYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQ 1275
Query: 835 -----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 868
+ +YFV + FG++ NL + ++++ F +
Sbjct: 1276 PEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314
Score = 90.5 bits (223), Expect = 2e-17
Identities = 61/168 (36%), Positives = 96/168 (57%), Gaps = 14/168 (8%)
Query: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFD--DFIFI-F 125
R C ++V + WFE + VILL+ L +D+ L ++ KI ++ + D IF
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVH-LENQPKIQELLNCTDIIFTHI 1100
Query: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
F +EMVLK VA G FGK Y W LDF IV+ + + + L + RT+R LRP
Sbjct: 1101 FILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTL---INLMELKSFRTLRALRP 1154
Query: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
L+A+++ M+++VN L+ +P + NVLL+C + +F I+GV ++G
Sbjct: 1155 LRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202
Score = 86.7 bits (213), Expect = 2e-16
Identities = 71/327 (21%), Positives = 138/327 (42%), Gaps = 60/327 (18%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
F+ I+ +++N V M + +N +I VFT ++ E ++K+ A G F
Sbjct: 131 FSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILARGFILDEF 188
Query: 698 DYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMK 757
+LR+P+N DSI++ I+I + L LRTFR+ R LK + + L+ + L++
Sbjct: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248
Query: 758 TMDNVATFCMLLMLFIFIFSILGMHIF-----------GCKFSLRTDTGDTVPDRK---- 802
++ + +L + IF+++G +F CK + D ++K
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSP 308
Query: 803 --------------------------------NFDSLLWAIVTVFQILTQEDWNVVLYNG 830
NFD+ W+ + +F+++TQ+ W +
Sbjct: 309 EFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQT 368
Query: 831 MASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQ-------AEGDANRSYSDEDQSSS 883
+ +T ++ +F+ ++ G++ L NL +A++ ++ AE +A E Q
Sbjct: 369 LRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLL 428
Query: 884 NIEEFDKLQEGLDSSGDPKLCPIPMTP 910
E+ + G+D S L TP
Sbjct: 429 KEEKEALVAMGIDRSSLTSLETSYFTP 455
Score = 83.2 bits (204), Expect = 3e-15
Identities = 68/321 (21%), Positives = 142/321 (44%), Gaps = 37/321 (11%)
Query: 1164 QTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKV 1223
+T++ + + I +N + +A+E ++EA S E++ L + N +FT+IF+ EM LK+
Sbjct: 571 RTVMTDPFTELAITICIIINTVFLAMEHHKMEA-SFEKM-LNIGNLVFTSIFIAEMCLKI 628
Query: 1224 VSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPL 1283
++L Y Y R WN+ D + +S D++ + L RVLR+ + +
Sbjct: 629 IALDPYH----YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW 684
Query: 1284 RVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNI 1343
P L +++ + +S+ +G++ ++ IF ++G+QLF F +++
Sbjct: 685 ------PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSF------NSQKS 732
Query: 1344 TNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNH 1403
+ + H + D L+ +L + W+ M+ + Q
Sbjct: 733 PKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE--WIENMWECM-------QEANAS 783
Query: 1404 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRK 1463
+ ++ FI +I VLN+F+ +++ +F ++ E R+ + +L L++ RR
Sbjct: 784 SSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRR- 841
Query: 1464 AQRLPYYATYCHTRLLIHSMC 1484
+C R + C
Sbjct: 842 --------AFCFVRHTLEHFC 854
Score = 80.1 bits (196), Expect = 2e-14
Identities = 68/324 (20%), Positives = 136/324 (41%), Gaps = 87/324 (26%)
Query: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1536
R+ +HS+ +FI + +N V M+ S T + C +FT +++ EA++
Sbjct: 124 RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176
Query: 1537 KLVAFGLR----RFFKDRWNQLDLAIVLLSVM----GITLEEIEINAALPINPTIIRIMR 1588
K++A G F +D WN LD ++ ++++ GIT++ LP+ R
Sbjct: 177 KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222
Query: 1589 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1641
R+ R LK + + + ++ ++ +++++ ++ N+ +L I+A +G +LF
Sbjct: 223 TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282
Query: 1642 -----------------------------------GKLVCNDENPCEGMS-----RHATF 1661
G C+ + C+ + F
Sbjct: 283 CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342
Query: 1662 ENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVL 1721
+NFG +FL +F++ T D+W + + TLR + S +F+ + F L
Sbjct: 343 DNFGWSFLAMFRLMTQDSWEKLYQQTLR-----------TTGLYSVFFFIVVIFLGSFYL 391
Query: 1722 INVVVAVLMKHLDDSNKEAQEDAE 1745
IN+ +AV+ ++ NK + E
Sbjct: 392 INLTLAVVTMAYEEQNKNVAAEIE 415
Score = 68.2 bits (165), Expect = 9e-11
Identities = 36/128 (28%), Positives = 72/128 (56%), Gaps = 15/128 (11%)
Query: 310 LNASGLCVNWNRYYNV--CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 367
+N + +N+ N C +G+ + +NFDN+G A++ + QV T +GW++I+Y +
Sbjct: 1208 INGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAV 1267
Query: 368 DA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLE 414
D+ + +IYF++ II GSFF +NL + VI F++ +++ + M E
Sbjct: 1268 DSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTE 1327
Query: 415 QRQRYLSS 422
++++Y ++
Sbjct: 1328 EQKKYYNA 1335
Score = 56.6 bits (135), Expect = 3e-07
Identities = 44/170 (25%), Positives = 82/170 (48%), Gaps = 13/170 (7%)
Query: 68 PRNWCIKMVC-----NPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFI 122
P+ C+K V +P+ E + I++N V L M M+ + K+L + +
Sbjct: 561 PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEH--HKMEASFE--KMLNIGNLVF 616
Query: 123 FIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEY-SLDLQNINLSAIRTVR 181
F EM LK++AL + Y WN D + + + + LQ + +R+ R
Sbjct: 617 TSIFIAEMCLKIIALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFR 673
Query: 182 VLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231
VLR K P++ L+ ++ +++ LG++ ++ V FIF ++G+QL+
Sbjct: 674 VLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723
Score = 50.8 bits (120), Expect = 1e-05
Identities = 42/174 (24%), Positives = 82/174 (47%), Gaps = 21/174 (12%)
Query: 68 PRNWC----IKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIF 123
P N C +V + F+ + + +I+LN +++ M + + + IL +
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISM-MAESYNQPKAMKS---ILDHLNWVFV 1406
Query: 124 IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-LQNIN--------L 174
+ F +E ++K+ AL ++ Y + WN D +V+ +V + L+N
Sbjct: 1407 VIFTLECLIKIFAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLF 1462
Query: 175 SAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGV 228
+R R+ R L+ + +R L+ L+ +LP L N+ LL F + FI+ I+G+
Sbjct: 1463 RIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM 1516
Score = 35.8 bits (81), Expect = 0.48
Identities = 22/76 (28%), Positives = 44/76 (57%), Gaps = 5/76 (6%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
++++V+F+++ E W+E M+ M +A S I FIL+ ++G ++NL + ++ F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814
Query: 402 SETKQREHRLMLEQRQ 417
S ++R L E R+
Sbjct: 815 S-NEERNGNLEGEARK 829
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 343 bits (881), Expect = 8e-94
Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C +I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ +V A+A G LG ++ LR LR
Sbjct: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+ +
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
Query: 1340 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391
T N + N SDC A RW + K NFDN+G ++L +A+ GW++IMY +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
Query: 1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451
+ V QPV N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
Query: 1452 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509
K ++K K + P + ++ T DI I +ICLN+VTM +E
Sbjct: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499
Query: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569
+Q + L N +F +F E VLKLV+ +F WN D +V+LS++G+ L
Sbjct: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557
Query: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629
E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL L+
Sbjct: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616
Query: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689
FIYA G+ F + G+ FE FG + + LFQ++T W+G++ L
Sbjct: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
Query: 1690 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1739
DC D SS++ V +FVS+++ + V++N+ +AV++++ + +E
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
Query: 1740 AQED-AEMDAELELEMAHGLGP 1760
+ E +E D E+ E+ P
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753
Score = 249 bits (637), Expect = 2e-65
Identities = 236/945 (24%), Positives = 418/945 (44%), Gaps = 130/945 (13%)
Query: 35 PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
P + EPL+ DP+ + A A + L R IK++ +
Sbjct: 70 PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F + M IL NCV + + P D K ++ I+ F E ++K++A G
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
+ +L D WN LDF +++ V + L N+ SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
L+ ++ L +V++L F +F +IG+QL+ G LRN+C + PP
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
E + + NG + + + D + G++D L +G
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKDY---IGDDSHFYVLDGQKDPLLCGNGSDA 343
Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
+C NP+ G +FD +A++ +F+++T + W + + A I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQ--RQRYLSSSTV 425
F+L+I +GSF+++NL L V+A + +E K+ E + MLEQ +Q+ + +
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463
Query: 426 ASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPR 485
A+ A D F + GL + L+S +A + + + K+ R
Sbjct: 464 AASAASRD-----FSGIG-----------GLGELLESSSEASKLSSKSAKEWRNRRKKRR 507
Query: 486 ---HYHGKTKGQGDEGRHLGSRHC--QTLHGPASPGND-HSGRELCPQHSPLDATPHTLV 539
H G KG+ D S ++ + GN S ++ C H L + +L
Sbjct: 508 QREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLF 567
Query: 540 QPIPATLAS---------------DPASCPCCQHEDG--RRPSGLGSTDSGQEGSGSGSS 582
P + S D A ED RR S G+ + +G++
Sbjct: 568 SPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTT 627
Query: 583 AGGEDEA--------------DGDGARSSEDGASSELGKEEEEEEQADGA---------- 618
E D G + + AS EE EE
Sbjct: 628 TETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANV 687
Query: 619 --VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
+W C D W + + + IV + + I + I++NT+ M +EH+ E+ +++L + N
Sbjct: 688 FLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Query: 677 VVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLL 736
+VFT +F EM+LK+ A + Y + +NIFD IIV +S+ E+ GLSVLR+FRLL
Sbjct: 748 LVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLL 807
Query: 737 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTD 793
RV KL + P L + ++ ++ + ++L + +FIF+++GM +FG + + +
Sbjct: 808 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN 867
Query: 794 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYV 852
T+P R + + + + VF++L E W +++ M + + F+ +M GN V
Sbjct: 868 DDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLV 925
Query: 853 LFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 926 VLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967
Score = 109 bits (273), Expect = 3e-23
Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)
Query: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538
L++ + ++D+ IT I LN + M++EHY + L N +FT +F E VLK+
Sbjct: 703 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
Query: 1539 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598
+A +F++ WN D IV LS+M + L +E + ++R R+ RV KL
Sbjct: 763 IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812
Query: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1654
K + L+ + ++ +GNL L+ ++ FI+A +G++LFGK VC + C
Sbjct: 813 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
Query: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1712
H +F +FL +F+V G+ W +T+ DC + CL + F+
Sbjct: 873 PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743
++ V++N+ +A+L+ N A +D
Sbjct: 918 VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948
Score = 107 bits (266), Expect = 2e-22
Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E + G + L+ N +F +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK+VSL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+ +NF+ G +++ LF + + GW ++ L++
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P T H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
Score = 100 bits (250), Expect = 1e-20
Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)
Query: 623 GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +LE + VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
Query: 681 SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735
+F LEM+LK A+G Y N + D +IV +S+ +V A G + LRT R
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
Query: 736 LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 791
LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F KF ++
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
Query: 792 TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 832
T + D + NFD++ + + Q+ T + W ++Y +
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
Query: 833 S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 882
S + + LYFV + FG++ NL + ++++ F + + + +D
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436
Query: 883 SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ EE K + G K PIP N
Sbjct: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464
Score = 98.6 bits (244), Expect = 6e-20
Identities = 91/373 (24%), Positives = 162/373 (43%), Gaps = 75/373 (20%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R + I+ H LF +++ I NC+ + L P + E
Sbjct: 107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ ++ + VSL
Sbjct: 159 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSL--------- 209
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Query: 1329 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1376
G + CL +T + + M +N +V+ +N+ D +G +
Sbjct: 270 MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
Query: 1377 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1409
KD + NG DA + + NP W L
Sbjct: 330 GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
Query: 1410 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1452
Y I F+L++ SF+++N+ + VV + + Q +EAE+ ++
Sbjct: 388 LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
Query: 1453 RLRRLEKKRRKAQ 1465
L +L+K++ +AQ
Sbjct: 448 MLEQLKKQQEEAQ 460
Score = 94.4 bits (233), Expect = 1e-18
Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)
Query: 1162 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1220
L I+ D + I LN + +A+E P E S+ LTV N +FT IF EM
Sbjct: 703 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
Query: 1221 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1280
LK++++ Y+ Y + WN+ DG +V +S++++ +S L VLR R L
Sbjct: 760 LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807
Query: 1281 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1340
R ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF + C+
Sbjct: 808 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863
Query: 1341 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
DC RW H +F L+ VL + W+ M++ ++
Sbjct: 864 --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
Query: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L+ F+ ++I + VLN+F+ +++ +F
Sbjct: 908 ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
Score = 90.5 bits (223), Expect = 2e-17
Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)
Query: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
R C +V + WFE + +ILL+ L + K + + D +F + F
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203
Query: 128 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
+EM+LK VA +G + Y + W LDF IV + +V +L + + ++RT+R L
Sbjct: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 184 RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
RPL+A++R MR++VN L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q + +T +L N+VF +F E +LKL +
Sbjct: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
V+ N+ +A+++E F + + ED E ++K
Sbjct: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750
Score = 70.1 bits (170), Expect = 2e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446
Score = 54.3 bits (129), Expect = 1e-06
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT+ M + D ++ +L + + F E VLK+V+L
Sbjct: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
+ Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
Score = 45.8 bits (107), Expect = 5e-04
Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 363 YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1751
F L+N+++AV+ ++ N+ E+AE +AE +
Sbjct: 412 SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 343 bits (881), Expect = 8e-94
Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C +I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ +V A+A G LG ++ LR LR
Sbjct: 1207 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+ +
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
Query: 1340 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391
T N + N SDC A RW + K NFDN+G ++L +A+ GW++IMY +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
Query: 1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451
+ V QPV N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439
Query: 1452 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509
K ++K K + P + ++ T DI I +ICLN+VTM +E
Sbjct: 1440 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1499
Query: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569
+Q + L N +F +F E VLKLV+ +F WN D +V+LS++G+ L
Sbjct: 1500 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1557
Query: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629
E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL L+
Sbjct: 1558 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1616
Query: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689
FIYA G+ F + G+ FE FG + + LFQ++T W+G++ L
Sbjct: 1617 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1671
Query: 1690 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1739
DC D SS++ V +FVS+++ + V++N+ +AV++++ + +E
Sbjct: 1672 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1731
Query: 1740 AQED-AEMDAELELEMAHGLGP 1760
+ E +E D E+ E+ P
Sbjct: 1732 SAEPLSEDDFEMFYEVWEKFDP 1753
Score = 252 bits (643), Expect = 3e-66
Identities = 237/945 (25%), Positives = 419/945 (44%), Gaps = 130/945 (13%)
Query: 35 PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
P + EPL+ DP+ + A A + L R IK++ +
Sbjct: 70 PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F + M IL NCV + + P D K ++ I+ F E ++K++A G
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
+ +L D WN LDF +++ V +DL N+ SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
L+ ++ L +V++L F +F +IG+QL+ G LRN+C + PP
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
E + + NG + + + D + G++D L +G
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKDY---IGDDSHFYVLDGQKDPLLCGNGSDA 343
Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
+C NP+ G +FD +A++ +F+++T + W + + A I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQ--RQRYLSSSTV 425
F+L+I +GSF+++NL L V+A + +E K+ E + MLEQ +Q+ + +
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463
Query: 426 ASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPR 485
A+ A D F + GL + L+S +A + + + K+ R
Sbjct: 464 AASAASRD-----FSGIG-----------GLGELLESSSEASKLSSKSAKEWRNRRKKRR 507
Query: 486 ---HYHGKTKGQGDEGRHLGSRHC--QTLHGPASPGND-HSGRELCPQHSPLDATPHTLV 539
H G KG+ D S ++ + GN S ++ C H L + +L
Sbjct: 508 QREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLF 567
Query: 540 QPIPATLAS---------------DPASCPCCQHEDG--RRPSGLGSTDSGQEGSGSGSS 582
P + S D A ED RR S G+ + +G++
Sbjct: 568 SPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNGTT 627
Query: 583 AGGEDEA--------------DGDGARSSEDGASSELGKEEEEEEQADGA---------- 618
E D G + + AS EE EE
Sbjct: 628 TETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANV 687
Query: 619 --VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICN 676
+W C D W + + + IV + + I + I++NT+ M +EH+ E+ +++L + N
Sbjct: 688 FLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGN 747
Query: 677 VVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLL 736
+VFT +F EM+LK+ A + Y + +NIFD IIV +S+ E+ GLSVLR+FRLL
Sbjct: 748 LVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLL 807
Query: 737 RVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTD 793
RV KL + P L + ++ ++ + ++L + +FIF+++GM +FG + + +
Sbjct: 808 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN 867
Query: 794 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYV 852
T+P R + + + + VF++L E W +++ M + + F+ +M GN V
Sbjct: 868 DDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLV 925
Query: 853 LFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 926 VLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 967
Score = 109 bits (273), Expect = 3e-23
Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)
Query: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538
L++ + ++D+ IT I LN + M++EHY + L N +FT +F E VLK+
Sbjct: 703 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762
Query: 1539 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598
+A +F++ WN D IV LS+M + L +E + ++R R+ RV KL
Sbjct: 763 IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 812
Query: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1654
K + L+ + ++ +GNL L+ ++ FI+A +G++LFGK VC + C
Sbjct: 813 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 872
Query: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1712
H +F +FL +F+V G+ W +T+ DC + CL + F+
Sbjct: 873 PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 917
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743
++ V++N+ +A+L+ N A +D
Sbjct: 918 VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 948
Score = 107 bits (266), Expect = 2e-22
Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E + G + L+ N +F +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK+VSL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1520 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+ +NF+ G +++ LF + + GW ++ L++
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P T H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725
Score = 100 bits (250), Expect = 1e-20
Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)
Query: 623 GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +LE + VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199
Query: 681 SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735
+F LEM+LK A+G Y N + D +IV +S+ +V A G + LRT R
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259
Query: 736 LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 791
LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F KF ++
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319
Query: 792 TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 832
T + D + NFD++ + + Q+ T + W ++Y +
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379
Query: 833 S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 882
S + + LYFV + FG++ NL + ++++ F + + + +D
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1436
Query: 883 SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ EE K + G K PIP N
Sbjct: 1437 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1464
Score = 97.1 bits (240), Expect = 2e-19
Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R + I+ H LF +++ I NC+ + L P + E
Sbjct: 107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ ++ + V L
Sbjct: 159 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Query: 1329 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1376
G + CL +T + + M +N +V+ +N+ D +G +
Sbjct: 270 MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
Query: 1377 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1409
KD + NG DA + + NP W L
Sbjct: 330 GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
Query: 1410 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1452
Y I F+L++ SF+++N+ + VV + + Q +EAE+ ++
Sbjct: 388 LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
Query: 1453 RLRRLEKKRRKAQ 1465
L +L+K++ +AQ
Sbjct: 448 MLEQLKKQQEEAQ 460
Score = 94.4 bits (233), Expect = 1e-18
Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)
Query: 1162 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1220
L I+ D + I LN + +A+E P E S+ LTV N +FT IF EM
Sbjct: 703 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759
Query: 1221 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1280
LK++++ Y+ Y + WN+ DG +V +S++++ +S L VLR R L
Sbjct: 760 LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 807
Query: 1281 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1340
R ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF + C+
Sbjct: 808 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 863
Query: 1341 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
DC RW H +F L+ VL + W+ M++ ++
Sbjct: 864 --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907
Query: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L+ F+ ++I + VLN+F+ +++ +F
Sbjct: 908 ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938
Score = 90.5 bits (223), Expect = 2e-17
Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)
Query: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
R C +V + WFE + +ILL+ L + K + + D +F + F
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1203
Query: 128 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
+EM+LK VA +G + Y + W LDF IV + +V +L + + ++RT+R L
Sbjct: 1204 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1260
Query: 184 RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
RPL+A++R MR++VN L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 1261 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q + +T +L N+VF +F E +LKL +
Sbjct: 1474 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1533
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1534 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1592
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1593 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1647
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1648 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1707
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
V+ N+ +A+++E F + + ED E ++K
Sbjct: 1708 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1750
Score = 70.1 bits (170), Expect = 2e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1446
Score = 54.3 bits (129), Expect = 1e-06
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT+ M + D ++ +L + + F E VLK+V+L
Sbjct: 1479 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1531
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
+ Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1532 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629
Score = 45.8 bits (107), Expect = 5e-04
Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 363 YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1751
F L+N+++AV+ ++ N+ E+AE +AE +
Sbjct: 412 SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 343 bits (881), Expect = 8e-94
Identities = 212/622 (34%), Positives = 344/622 (55%), Gaps = 36/622 (5%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C +I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ +V A+A G LG ++ LR LR
Sbjct: 1256 LLKWVA----YGFQTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+ +
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
Query: 1340 TRN------ITNRSDCMA--ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLD 1391
T N + N SDC A RW + K NFDN+G ++L +A+ GW++IMY +D
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
Query: 1392 AVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451
+ V QPV N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++ EE
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488
Query: 1452 --KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHY 1509
K ++K K + P + ++ T DI I +ICLN+VTM +E
Sbjct: 1489 QKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD 1548
Query: 1510 NQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE 1569
+Q + L N +F +F E VLKLV+ +F WN D +V+LS++G+ L
Sbjct: 1549 DQGKYMTLVLSRINLVFIVLFTGEFVLKLVSL-RHYYFTIGWNIFDFVVVILSIVGMFL- 1606
Query: 1570 EIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLL 1629
E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL L+
Sbjct: 1607 -AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1665
Query: 1630 FFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLR 1689
FIYA G+ F + G+ FE FG + + LFQ++T W+G++ L
Sbjct: 1666 MFIYAIFGMSNFAYV-----KKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILN 1720
Query: 1690 ----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE 1739
DC D SS++ V +FVS+++ + V++N+ +AV++++ + +E
Sbjct: 1721 SAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1780
Query: 1740 AQED-AEMDAELELEMAHGLGP 1760
+ E +E D E+ E+ P
Sbjct: 1781 SAEPLSEDDFEMFYEVWEKFDP 1802
Score = 151 bits (382), Expect = 6e-36
Identities = 112/428 (26%), Positives = 201/428 (46%), Gaps = 43/428 (10%)
Query: 486 HYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPAT 545
H HG+ + + SR PG +G+ HS +D + P+
Sbjct: 615 HRHGERRNSNVSQASMSSRMV--------PGLPANGK----MHSTVDCNGVVSLVGGPSA 662
Query: 546 LASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSEL 605
L S P P G + ++ S E D G + + AS
Sbjct: 663 LTSPTGQLP---------PEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILT 713
Query: 606 GKEEEEEEQADGA------------VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVN 653
EE EE +W C D W + + + IV + + I + I++N
Sbjct: 714 NTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLN 773
Query: 654 TVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVI 713
T+ M +EH+ E+ +++L + N+VFT +F EM+LK+ A + Y + +NIFD IIV
Sbjct: 774 TLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVS 833
Query: 714 ISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFI 773
+S+ E+ GLSVLR+FRLLRV KL + P L + ++ ++ + ++L + +
Sbjct: 834 LSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIV 893
Query: 774 FIFSILGMHIFGCKFS---LRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG 830
FIF+++GM +FG + + + T+P R + + + + VF++L E W +++
Sbjct: 894 FIFAVVGMQLFGKSYKECVCKINDDCTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDC 951
Query: 831 M-ASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EF 888
M + + F+ +M GN V+ NL +A+L+ F ++ N + +D+D +N++
Sbjct: 952 MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAV 1008
Query: 889 DKLQEGLD 896
++Q+G+D
Sbjct: 1009 GRMQKGID 1016
Score = 130 bits (327), Expect = 1e-29
Identities = 107/411 (26%), Positives = 186/411 (45%), Gaps = 53/411 (12%)
Query: 35 PPGLEEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNPW 80
P + EPL+ DP+ + A A + L R IK++ +
Sbjct: 70 PEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL 129
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F + M IL NCV + + P D K ++ I+ F E ++K++A G
Sbjct: 130 FSMLIMCTILTNCVFMTLSNP-------PDWTKNVEYTFTGIYTF---ESLIKILARGFC 179
Query: 141 GKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILV 199
+ +L D WN LDF +++ V +DL N+ SA+RT RVLR LK I+ +P ++ +V
Sbjct: 180 LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNV--SALRTFRVLRALKTISVIPGLKTIV 237
Query: 200 NLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQP 259
L+ ++ L +V++L F +F +IG+QL+ G LRN+C + PP
Sbjct: 238 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC-----------LQWPPSDSA 286
Query: 260 EEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQD--LNASGLCV 317
E + + NG + + + D + G++D L +G
Sbjct: 287 FETNTTSYFNGTMDSNGTFVNVTMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDA 343
Query: 318 NWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIY 377
+C NP+ G +FD +A++ +F+++T + W + + A I+
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403
Query: 378 FILLIIVGSFFMINLCLVVIATQF----------SETKQREHRLMLEQRQR 418
F+L+I +GSF+++NL L V+A + +E K+ E + MLEQ ++
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 454
Score = 109 bits (273), Expect = 3e-23
Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 31/271 (11%)
Query: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKL 1538
L++ + ++D+ IT I LN + M++EHY + L N +FT +F E VLK+
Sbjct: 752 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
Query: 1539 VAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKL 1598
+A +F++ WN D IV LS+M + L +E + ++R R+ RV KL
Sbjct: 812 IAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----------GLSVLRSFRLLRVFKL 861
Query: 1599 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEG 1654
K + L+ + ++ +GNL L+ ++ FI+A +G++LFGK VC + C
Sbjct: 862 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTL 921
Query: 1655 MSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVS 1712
H +F +FL +F+V G+ W +T+ DC + CL + F+
Sbjct: 922 PRWH--MNDFFHSFLIVFRVLCGE-W----IETMWDCMEVAGQTMCL--------IVFML 966
Query: 1713 FVLTAQFVLINVVVAVLMKHLDDSNKEAQED 1743
++ V++N+ +A+L+ N A +D
Sbjct: 967 VMVIGNLVVLNLFLALLLSSFSSDNLAATDD 997
Score = 107 bits (266), Expect = 2e-22
Identities = 75/291 (25%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E + G + L+ N +F +
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK+VSL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1569 FTGEFVLKLVSLRHY-----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+ +NF+ G +++ LF + + GW ++ L++
Sbjct: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P T H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
Score = 100 bits (250), Expect = 1e-20
Identities = 81/330 (24%), Positives = 149/330 (45%), Gaps = 46/330 (13%)
Query: 623 GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFT 680
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +LE + VFT
Sbjct: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248
Query: 681 SMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGLSVLRTFRL 735
+F LEM+LK A+G Y N + D +IV +S+ +V A G + LRT R
Sbjct: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308
Query: 736 LRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF----SLR 791
LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F KF ++
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368
Query: 792 TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 832
T + D + NFD++ + + Q+ T + W ++Y +
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428
Query: 833 S----------TSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSS 882
S + + LYFV + FG++ NL + ++++ F + + + +D
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ---KKKFGGQDIFM 1485
Query: 883 SNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ EE K + G K PIP N
Sbjct: 1486 T--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1513
Score = 97.1 bits (240), Expect = 2e-19
Identities = 90/373 (24%), Positives = 161/373 (43%), Gaps = 75/373 (20%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R + I+ H LF +++ I NC+ + L P + E
Sbjct: 107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVE-------- 158
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ ++ + V L
Sbjct: 159 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--------- 209
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 210 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269
Query: 1329 KGKFYH-CL-------GVDTRNITNRSDCMAANYRWVH---HKYNF-DNLGQALMSLFVL 1376
G + CL +T + + M +N +V+ +N+ D +G +
Sbjct: 270 MGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLD 329
Query: 1377 ASKDGWVNIMYNGLDAVAVDQQPV---TNHNP-----------WMLL------------- 1409
KD + NG DA + + NP W L
Sbjct: 330 GQKDPL--LCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWEN 387
Query: 1410 ------------YFISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEK 1452
Y I F+L++ SF+++N+ + VV + + Q +EAE+ ++
Sbjct: 388 LYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 447
Query: 1453 RLRRLEKKRRKAQ 1465
L +L+K++ +AQ
Sbjct: 448 MLEQLKKQQEEAQ 460
Score = 94.4 bits (233), Expect = 1e-18
Identities = 71/274 (25%), Positives = 128/274 (46%), Gaps = 39/274 (14%)
Query: 1162 LCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTAIFVGEMT 1220
L I+ D + I LN + +A+E P E S+ LTV N +FT IF EM
Sbjct: 752 LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 808
Query: 1221 LKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTL 1280
LK++++ Y+ Y + WN+ DG +V +S++++ +S L VLR R L
Sbjct: 809 LKIIAMDPYY----YFQEGWNIFDGIIVSLSLMELGLSNVEG--------LSVLRSFRLL 856
Query: 1281 RPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDT 1340
R ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF + C+
Sbjct: 857 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV---- 912
Query: 1341 RNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPV 1400
DC RW H +F L+ VL + W+ M++ ++
Sbjct: 913 --CKINDDCTLP--RW--HMNDF--FHSFLIVFRVLCGE--WIETMWDCMEVAG------ 956
Query: 1401 TNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L+ F+ ++I + VLN+F+ +++ +F
Sbjct: 957 ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987
Score = 90.5 bits (223), Expect = 2e-17
Identities = 58/170 (34%), Positives = 93/170 (54%), Gaps = 11/170 (6%)
Query: 69 RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FA 127
R C +V + WFE + +ILL+ L + K + + D +F + F
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFI 1252
Query: 128 MEMVLKMVALGIFGKKCYLGDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVL 183
+EM+LK VA +G + Y + W LDF IV + +V +L + + ++RT+R L
Sbjct: 1253 LEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL 1309
Query: 184 RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
RPL+A++R MR++VN L+ +P + NVLL+C + IF I+GV L+AG
Sbjct: 1310 RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359
Score = 89.0 bits (219), Expect = 5e-17
Identities = 72/283 (25%), Positives = 135/283 (47%), Gaps = 35/283 (12%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q + +T +L N+VF +F E +LKL +
Sbjct: 1523 VTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRH 1582
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1583 Y-YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1641
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1642 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG--IDDMFNFETFG 1696
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1697 NSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYII 1756
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
V+ N+ +A+++E F + + ED E ++K
Sbjct: 1757 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1799
Score = 70.1 bits (170), Expect = 2e-11
Identities = 46/148 (31%), Positives = 83/148 (56%), Gaps = 13/148 (8%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
F+ IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 130 FSMLIMCTILTNCVFMTLSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 183
Query: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
+LR+P+N D S+IV+ + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 184 TFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 241
Query: 757 KTMDNVATFCMLLMLFIFIFSILGMHIF 784
+++ ++ +L + + +F+++G+ +F
Sbjct: 242 QSVKKLSDVMILTVFCLSVFALIGLQLF 269
Score = 70.1 bits (170), Expect = 2e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1495
Score = 66.2 bits (160), Expect = 3e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
+V +P+ + + I+LN + + M + +L V + F EMVLK+
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
+A+ + Y + WN D IV ++E L L N+ LS +R+ R+LR K P
Sbjct: 812 IAMDPY---YYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWP 866
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 867 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCTL 921
Query: 254 PPYY 257
P ++
Sbjct: 922 PRWH 925
Score = 54.3 bits (129), Expect = 1e-06
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 15/159 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT+ M + D ++ +L + + F E VLK+V+L
Sbjct: 1528 FDISIMILICLNMVTM-MVETDDQGKYMT---LVLSRINLVFIVLFTGEFVLKLVSL--- 1580
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
+ Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1581 -RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678
Score = 47.8 bits (112), Expect = 1e-04
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 365 SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424
Query: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893
++ + A +++ ++ +E+ K QE
Sbjct: 425 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 457
Score = 45.8 bits (107), Expect = 5e-04
Identities = 26/95 (27%), Positives = 49/95 (51%), Gaps = 12/95 (12%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 363 YTSFDTFSWAFLSLFRLMTQDYWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 411
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE 1751
F L+N+++AV+ ++ N+ E+AE +AE +
Sbjct: 412 SFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQ 446
Score = 35.8 bits (81), Expect = 0.48
Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 2/59 (3%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
++++++F+V+ E W+E M+ M+ A I F+L++++G+ ++NL L ++ + FS
Sbjct: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 342 bits (877), Expect = 2e-93
Identities = 209/625 (33%), Positives = 345/625 (55%), Gaps = 39/625 (6%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C I+ H F+ ++ I L+ +A E IE T +I L ++ IFT IF+ EM
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK ++ +G + Y ++W LD +V VS++ +V A+ G LG ++ LR LR
Sbjct: 1231 LLKWIA----YGYKTYFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVD 1339
LRPLR +SR G+++VV LI ++ I N++L+C F++IF I+GV LF GKFY C+
Sbjct: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343
Query: 1340 ------TRNITNRSDCMAA-----NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388
+ NRS+C A N RW + K NFDN+G +SL +A+ GW IMY
Sbjct: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403
Query: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448
+D+V VD+QP ++ +M +YF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463
Query: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506
EE K ++K K + P + I + T+ DI I +ICLN+VTM +
Sbjct: 1464 TEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMV 1523
Query: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566
E Q + L + N +F +F E VLKL++ +F WN D +V++S++G+
Sbjct: 1524 EKEGQSQHMTEVLYWINVVFIILFTGECVLKLISL-RHYYFTVGWNIFDFVVVIISIVGM 1582
Query: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626
L ++ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1583 FL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLL 1640
Query: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686
L+ FIYA G+ F + D G++ FE FG + + LFQ++T W+G++
Sbjct: 1641 FLVMFIYAIFGMSNFAYVKKED-----GINDMFNFETFGNSMICLFQITTSAGWDGLLAP 1695
Query: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
L DC + SS++ V YFVS+++ + V++N+ +AV++++ +
Sbjct: 1696 ILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVA 1755
Query: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760
+E+ E +E D E+ E+ P
Sbjct: 1756 TEESTEPLSEDDFEMFYEVWEKFDP 1780
Score = 151 bits (381), Expect = 8e-36
Identities = 86/272 (31%), Positives = 155/272 (56%), Gaps = 9/272 (3%)
Query: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
+W C W + + + IV + + I + I++NT+ M +EHH EE N+L I N+V
Sbjct: 712 IWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLV 771
Query: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738
FT +FA EM+LKL A ++Y + +NIFDS+IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 772 FTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRV 831
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFS---LRTDTG 795
KL + P L + ++ ++ + ++L + +FIF+++GM +FG + + +
Sbjct: 832 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDD 891
Query: 796 DTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSPWASLYFVALMTFGNYVLF 854
T+P R + + + + VF++L E W +++ M + + ++ +M GN V+
Sbjct: 892 CTLP-RWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL 949
Query: 855 NLLVAILVEGFQAEGDANRSYSDEDQSSSNIE 886
NL +A+L+ F ++ N + +ED ++N++
Sbjct: 950 NLFLALLLSSFSSD---NLTAIEEDPDANNLQ 978
Score = 132 bits (333), Expect = 3e-30
Identities = 107/391 (27%), Positives = 182/391 (46%), Gaps = 66/391 (16%)
Query: 35 PPGL-EEPLDGADPHVPHPDL--------------APIAFFCLRQTTSPRNWCIKMVCNP 79
PPG+ EPL+ DP+ A A + L + R IK++ +
Sbjct: 67 PPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHS 126
Query: 80 WFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGI 139
F + M IL NC+ + M P D K ++ I+ F E ++K++A G
Sbjct: 127 LFSMLIMCTILTNCIFMTMNNP-------PDWTKNVEYTFTGIYTF---ESLVKILARGF 176
Query: 140 -FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRIL 198
G+ +L D WN LDF +++ + ++L N+ SA+RT RVLR LK I+ +P ++ +
Sbjct: 177 CVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNV--SALRTFRVLRALKTISVIPGLKTI 234
Query: 199 VNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCF---LEENFTIQGDVALPP 255
V L+ ++ L +V++L F +F +IG+QL+ G L+++CF LE N T++ ++
Sbjct: 235 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLE---SIMN 291
Query: 256 YYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGL 315
+ EED F + ++ C S D SG
Sbjct: 292 TLESEEDFRKYFYYLEGSKDALL--------------CGFSTD--------------SGQ 323
Query: 316 CVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF 375
C Y + G NP G +FD +A++ +F+++T + W + + A
Sbjct: 324 CPEG---YTCVKIG-RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYM 379
Query: 376 IYFILLIIVGSFFMINLCLVVIATQFSETKQ 406
I+F+++I +GSF++INL L V+A + E Q
Sbjct: 380 IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
Score = 126 bits (317), Expect = 2e-28
Identities = 111/413 (26%), Positives = 186/413 (45%), Gaps = 102/413 (24%)
Query: 40 EPLDGADPHVPHPDLAPIAFFCLRQTTSP---------RNWCIKMVCNPWFECVSMLVIL 90
EP++ +P D F C + R C K+V + WFE +L+IL
Sbjct: 1133 EPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMIL 1192
Query: 91 LNCVTLGMYQPCDDMDCLSDRCKILQV---FDDFIFIF-FAMEMVLKMVALGIFGKKCYL 146
L+ L D +R K +++ + D IF + F +EM+LK +A +G K Y
Sbjct: 1193 LSSGALAFE------DIYIERKKTIKIILEYADKIFTYIFILEMLLKWIA---YGYKTYF 1243
Query: 147 GDTWNRLDFFIV---MAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVPSMRILVNLL 202
+ W LDF IV + +V +L ++ + ++RT+R LRPL+A++R MR++VN L
Sbjct: 1244 TNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNAL 1303
Query: 203 LDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEED 262
+ +P + NVLL+C + IF I+GV L+AG +Y+
Sbjct: 1304 IGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG---------------------KFYE---- 1338
Query: 263 DEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRY 322
C + D ++P R C + +V Q++ L VN++
Sbjct: 1339 ------CINTTDGSRFPASQVP-----NRSECFALMNV------SQNVRWKNLKVNFDNV 1381
Query: 323 YNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSF 372
+GY + + QV T +GW IMY +D+ +S
Sbjct: 1382 -------------------GLGY--LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSL 1420
Query: 373 YNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
Y +IYF++ II GSFF +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1421 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNA 1473
Score = 114 bits (284), Expect = 1e-24
Identities = 87/364 (23%), Positives = 159/364 (43%), Gaps = 73/364 (20%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ SP + R + I+ H LF +++ I NCI + + P + E
Sbjct: 105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVE-------- 156
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G GE +LR WN LD ++ + + V+L
Sbjct: 157 YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--------- 207
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 208 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267
Query: 1329 KGK--------------------------------FYHCLG----------VDTRNITNR 1346
G FY+ G D+
Sbjct: 268 MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327
Query: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406
C+ + +FD A ++LF L ++D W N+ QQ +
Sbjct: 328 YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLY----------QQTLRAAGKT 377
Query: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE---EKRLRRLEKKRRK 1463
+++F+ + + SF+++N+ + VV + + Q EEA+++E ++ L RL+K++ +
Sbjct: 378 YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKEQEE 436
Query: 1464 AQRL 1467
A+ +
Sbjct: 437 AEAI 440
Score = 107 bits (268), Expect = 1e-22
Identities = 124/578 (21%), Positives = 245/578 (42%), Gaps = 83/578 (14%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 403
++++++F+V+ E W+E M+ M+ A I +++++++G+ ++NL L ++ + FS
Sbjct: 904 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSS 962
Query: 404 TKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR 463
++ +E+ + + + G YV LR+ +A +
Sbjct: 963 ----DNLTAIEEDPDANNLQIAVTRIKKG------INYVKQTLREFILKAFSKKPKISRE 1012
Query: 464 -RQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGR 522
RQA + K+ + T + +G H + + G S + H
Sbjct: 1013 IRQA----------EDLNTKKENYISNHTLAEMSKG-HNFLKEKDKISGFGSSVDKHLME 1061
Query: 523 ELCPQ---HSPLDATPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGS 579
+ Q H+P T + P + L + A + L + S + +
Sbjct: 1062 DSDGQSFIHNP-SLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVD 1120
Query: 580 GSSAGGEDEADGDGARSSE------DGASSELGKEEEEEEQADGAVWLCGDVWRETRAKL 633
G +EA+ + S E DG + E G +W W R
Sbjct: 1121 NPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIW-----W-NIRKTC 1174
Query: 634 RGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNILEICNVVFTSMFALEMILKL 691
IV+ +F I++ IL+++ ++ E + E+ + + ILE + +FT +F LEM+LK
Sbjct: 1175 YKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKW 1234
Query: 692 AAFGLFDYLRNPYNIFDSIIVIISIWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFMP 746
A+G Y N + D +IV +S+ +V G +D G + LRT R LR L+ +
Sbjct: 1235 IAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFE 1294
Query: 747 ALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGD-------TVP 799
+R + L+ + ++ ++ ++F IFSI+G+++F KF +T D VP
Sbjct: 1295 GMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVP 1354
Query: 800 DRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLYNGMAST------ 834
+R NFD++ +++ Q+ T + W +++Y + S
Sbjct: 1355 NRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP 1414
Query: 835 ----SPWASLYFVALMTFGNYVLFNLLVAILVEGFQAE 868
S + +YFV + FG++ NL + ++++ F +
Sbjct: 1415 KYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452
Score = 107 bits (266), Expect = 2e-22
Identities = 82/309 (26%), Positives = 147/309 (47%), Gaps = 34/309 (11%)
Query: 1441 QEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLN 1500
+E EE+R++ R K PY+ + + I+ + ++D+ IT I LN
Sbjct: 690 EELEESRQKCPPWWYRFAHKFLIWNCSPYWIKF---KKCIYFIVMDPFVDLAITICIVLN 746
Query: 1501 VVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVL 1560
+ M++EH+ + L N +FT +F E VLKL+A +F+ WN D IV
Sbjct: 747 TLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 806
Query: 1561 LSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1620
LS++ + L ++E + ++R R+ RV KL K + L+ + ++ +G
Sbjct: 807 LSLVELFLADVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 856
Query: 1621 NLGLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVST 1676
NL L+ ++ FI+A +G++LFGK VC + C H +F +FL +F+V
Sbjct: 857 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MNDFFHSFLIVFRVLC 914
Query: 1677 GDNWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1734
G+ W +T+ DC + CL + ++ ++ V++N+ +A+L+
Sbjct: 915 GE-W----IETMWDCMEVAGQAMCL--------IVYMMVMVIGNLVVLNLFLALLLSSFS 961
Query: 1735 DSNKEAQED 1743
N A E+
Sbjct: 962 SDNLTAIEE 970
Score = 102 bits (254), Expect = 4e-21
Identities = 73/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+ + ++ ++ FD ++ I LN +T+ +E+ TE ++ N +F +
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWI--NVVFIIL 1546
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1547 FTGECVLKLISLRHY-----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR++ A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA----- 1656
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+ D ++ +NF+ G +++ LF + + GW ++ L++
Sbjct: 1657 --------YVKKED-------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P H NP + + YF+S+++I V+NM++ V++ENF
Sbjct: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752
Score = 94.7 bits (234), Expect = 9e-19
Identities = 78/287 (27%), Positives = 131/287 (45%), Gaps = 41/287 (14%)
Query: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
+V ++ F+ IM+ I +N V+M +E Q + +T +L NVVF +F E +LKL +
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559
Query: 696 LFDYLRNPYNIFDSIIVIISIWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 744
+ Y +NIFD ++VIIS IVG L V+R R+ R+L+LV+
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615
Query: 745 MPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNF 804
+R L LM ++ + +LL L +FI++I GM F D + D NF
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA-----YVKKEDGINDMFNF 1670
Query: 805 DSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFV 843
++ +++ +FQI T W+ +L + S P YFV
Sbjct: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730
Query: 844 ALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDK 890
+ + V+ N+ +A+++E F + + ED E ++K
Sbjct: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEK 1777
Score = 86.3 bits (212), Expect = 3e-16
Identities = 72/298 (24%), Positives = 133/298 (44%), Gaps = 40/298 (13%)
Query: 1139 PDWCEVREDWSVYLFSPE-NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEA 1196
P W + ++ SP +F+ I+ D + I LN + +A+E P E
Sbjct: 701 PWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEE 760
Query: 1197 GSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIV 1256
L + N +FT IF EM LK++++ Y Y + WN+ D +V +S++++
Sbjct: 761 FKN---VLAIGNLVFTGIFAAEMVLKLIAMDPY----EYFQVGWNIFDSLIVTLSLVELF 813
Query: 1257 VSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAF 1316
LA G L VLR R LR ++ P L ++++ + +S+ +GN+ L+
Sbjct: 814 --LADVEG------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAII 865
Query: 1317 FIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVL 1376
IF ++G+QLF + C+ DC RW H +F L+ VL
Sbjct: 866 VFIFAVVGMQLFGKSYKECV------CKINDDCTLP--RW--HMNDF--FHSFLIVFRVL 913
Query: 1377 ASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
+ W+ M++ ++ L+ ++ ++I + VLN+F+ +++ +F
Sbjct: 914 CGE--WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960
Score = 84.0 bits (206), Expect = 2e-15
Identities = 66/293 (22%), Positives = 134/293 (45%), Gaps = 70/293 (23%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
F+ IM IL N + M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 128 FSMLIMCTILTNCIFMTMNN---PPDWTKNVEY---TFTGIYTFESLVKILARGFCVGEF 181
Query: 698 DYLRNPYNIFDSIIVIIS-IWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
+LR+P+N D ++++ + + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 182 TFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 239
Query: 757 KTMDNVATFCMLLMLFIFIFSILGM----------------------------------- 781
+++ ++ +L + + +F+++G+
Sbjct: 240 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDF 299
Query: 782 -----HIFGCKFSL----RTDTGDTV-----------PDR--KNFDSLLWAIVTVFQILT 819
++ G K +L TD+G PD +FD+ WA + +F+++T
Sbjct: 300 RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMT 359
Query: 820 QEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 872
Q+ W + + + ++FV ++ G++ L NL++A++ ++ + AN
Sbjct: 360 QDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412
Score = 67.4 bits (163), Expect = 1e-10
Identities = 50/185 (27%), Positives = 95/185 (51%), Gaps = 17/185 (9%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
+V +P+ + + I+LN + + M + +++ K + + +F FA EMVLK
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAM-----EHHPMTEEFKNVLAIGNLVFTGIFAAEMVLK 783
Query: 134 MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSL-DLQNINLSAIRTVRVLRPLKAINRV 192
++A+ + Y WN D IV +VE L D++ LS +R+ R+LR K
Sbjct: 784 LIAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVEG--LSVLRSFRLLRVFKLAKSW 838
Query: 193 PSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVA 252
P++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D
Sbjct: 839 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKINDDCT 893
Query: 253 LPPYY 257
LP ++
Sbjct: 894 LPRWH 898
Score = 63.9 bits (154), Expect = 2e-09
Identities = 73/338 (21%), Positives = 134/338 (39%), Gaps = 95/338 (28%)
Query: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1536
++L+HS+ F I+C + N P K Y FT ++ E+++
Sbjct: 121 KILVHSL--------FSMLIMCTILTNCIFMTMNNPPDWT---KNVEYTFTGIYTFESLV 169
Query: 1537 KLVAFGLR----RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRI 1592
K++A G F +D WN LD +++ + L E +N + +R R+
Sbjct: 170 KILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALRTFRV 218
Query: 1593 ARVLKLLKMATGMRALLDTVVQALPQVGNLGLL--FMLLFFIYAALGV------------ 1638
R LK + + G++ ++ ++Q++ ++ ++ +L F L F L +
Sbjct: 219 LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278
Query: 1639 ------------------ELFGK-----------LVCN---DENPC-EGMS--------- 1656
E F K L+C D C EG +
Sbjct: 279 SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338
Query: 1657 -RHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVL 1715
+ +F+ F AFL LF++ T D W + + TLR + ++FV +
Sbjct: 339 YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR-----------AAGKTYMIFFVVVIF 387
Query: 1716 TAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELE 1753
F LIN+++AV+ ++ N+ E+A+ ELE +
Sbjct: 388 LGSFYLINLILAVVAMAYEEQNQANIEEAK-QKELEFQ 424
Score = 55.5 bits (132), Expect = 6e-07
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 15/165 (9%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
+V N F+ M++I LN VT+ + + ++L + I F E VLK+
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMT----EVLYWINVVFIILFTGECVLKL 1555
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLK 187
++L + Y WN DF +V+ +V L + IR R+ R L+
Sbjct: 1556 ISL----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611
Query: 188 AINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+ +R L+ L+ +LP L N+ LL F V FI+ I G+ +A
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656
Score = 31.6 bits (70), Expect = 9.1
Identities = 18/85 (21%), Positives = 35/85 (41%), Gaps = 21/85 (24%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDA---------------------HSFYNFIY 377
NF+ G + I +FQ+ T GW ++ ++++ + Y
Sbjct: 1669 NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFY 1728
Query: 378 FILLIIVGSFFMINLCLVVIATQFS 402
F+ II+ ++N+ + VI FS
Sbjct: 1729 FVSYIIISFLVVVNMYIAVILENFS 1753
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 338 bits (866), Expect = 5e-92
Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ + A+A G LG ++ LR LR
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
Query: 1338 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388
D + N S+C A RW + K NFDN+G +SL +A+ GW++IMY
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
Query: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
Query: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506
EE K ++K K + P + ++ T DI I +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
Query: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566
E +Q + L + N +F +F E VLKL++ +F WN D +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
Query: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
Query: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686
L+ FIYA G+ F + G+ FE FG + + LFQ++T W+G++
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
Query: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
L DC D+ SS++ V +FVS+++ + V++N+ +AV++++ +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
Query: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760
+E+ E +E D E+ E+ P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
Score = 143 bits (360), Expect = 2e-33
Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
+W C W + + + +V + + I + I++NT+ M +EH+ E+ +++L + N+V
Sbjct: 738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
Query: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738
FT +F EM LK+ A + Y + +NIFD IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 791
KL + P L + ++ ++ + ++L + +FIF+++GM +FG CK S
Sbjct: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
Query: 792 TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 850
D R + + + VF++L E W +++ M L F+ +M GN
Sbjct: 916 ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Query: 851 YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
V+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 972 LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
Score = 129 bits (323), Expect = 4e-29
Identities = 109/392 (27%), Positives = 181/392 (46%), Gaps = 42/392 (10%)
Query: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
A + L R IK++ + F + M IL NCV + M P D K ++
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
I+ F E ++K++A G + +L D WN LDF ++ V ++L N+ SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNV--SA 215
Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+RT RVLR LK I+ +P ++ +V L+ ++ L +V++L F +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
N+C + PP E + F + NG + E
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
K Y F G+ D G + + +C NP+ G +FD +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
T + W + + A I+F+L+I +GSF++INL L V+A + +E
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
K+ E + MLEQ +Q ++ A+ AE D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
Score = 112 bits (280), Expect = 4e-24
Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)
Query: 1454 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1502
+ LE+ R+K Y +A C + L++ + ++D+ IT I LN +
Sbjct: 715 MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
Query: 1503 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1562
M++EHY + L N +FT +F E LK++A +F++ WN D IV LS
Sbjct: 775 FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
Query: 1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1622
+M + L +E + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 835 LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
Query: 1623 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
L+ ++ FI+A +G++LFGK VC N CE H +F +FL +F+V G+
Sbjct: 885 TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
Query: 1679 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
W +T+ DC + CL+ F+ ++ V++N+ +A+L+
Sbjct: 943 -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Query: 1737 NKEAQED 1743
N A +D
Sbjct: 990 NLAATDD 996
Score = 102 bits (255), Expect = 3e-21
Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E T ++ N +F +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+G+D +NF+ G +++ LF + + GW ++ L++
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P +H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213
P + + L ++ D + I LN + +A+E P E S+ L+V N +FT
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
Query: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273
IF EM LK++++ Y+ Y + WN+ DGF+V +S++++ LA+ G L V
Sbjct: 801 IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
Query: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
LR R LR ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF +
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393
C+ I+N DC RW H D L+ VL + W+ M++ ++
Sbjct: 909 ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
Query: 1394 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L F+ ++I + VLN+F+ +++ +F
Sbjct: 955 G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
Score = 97.1 bits (240), Expect = 2e-19
Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)
Query: 569 STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 622
S++S E S +A E + +G E+ EE E +A + V + C
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 623 --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 672
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 673 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 727
E + VFT +F LEM+LK A+G Y N + D +IV +S+ + A G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 728 SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787
LRT R LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 788 F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 821
F + TG+ + NFD++ +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
Query: 822 DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 871
W ++Y + S + + LYFV + FG++ NL + ++++ F +
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
Query: 872 NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ + +D + EE K + G K PIP N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
Score = 96.3 bits (238), Expect = 3e-19
Identities = 85/371 (22%), Positives = 157/371 (42%), Gaps = 71/371 (19%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R L I+ H LF+ +++ I NC+ + + P + E
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ + + V+L
Sbjct: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNL--------- 210
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Query: 1329 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377
G + CL N N D + +N+D + + L
Sbjct: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
Query: 1378 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1410
+ +G++ N Y D + + + + W LY
Sbjct: 331 GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
Query: 1411 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454
I F+L++ SF+++N+ + VV + + Q +EAE+ ++ L
Sbjct: 391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
Query: 1455 RRLEKKRRKAQ 1465
+L+K++ +AQ
Sbjct: 451 EQLKKQQEEAQ 461
Score = 95.9 bits (237), Expect = 4e-19
Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 30 SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
S S + P +G P V P L P A F C+R+ + R
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
Query: 71 WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
C K+V + WFE + +ILL+ L + K + + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
Query: 130 MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
M+LK VA +G + Y + W LDF IV +V + + + + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
Query: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
L+A++R MR++VN LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
Score = 95.9 bits (237), Expect = 4e-19
Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q +E+TNIL N+VF +F E +LKL +
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 894
V+ N+ +A+++E F + + ED ++ EF KL +
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
Query: 895 LDSSGDPKLCPIP 907
D+ P L P
Sbjct: 1822 ADALDPPLLIAKP 1834
Score = 70.9 bits (172), Expect = 1e-11
Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
FN IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
Query: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
+LR+P+N D ++I + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVNL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 757 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
+++ ++ +L + + +F+++G+ +F +LR PD +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
Score = 69.7 bits (169), Expect = 3e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
+V +P+ + + I+LN + + M + +L V + F EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
+A+ + Y + WN D FIV ++E L L N+ LS +R+ R+LR K P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
Query: 254 PPYY 257
P ++
Sbjct: 921 PRWH 924
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT M DD + IL + + F E VLK+++L +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1774
F LIN+++AV+ ++ N+ E+AE +AE + LE + + A R
Sbjct: 413 SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Query: 1775 GPGGAGGGG 1783
GAGG G
Sbjct: 473 DFSGAGGIG 481
Score = 48.1 bits (113), Expect = 9e-05
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
Query: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893
++ + A +++ ++ +E+ K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
Score = 33.1 bits (74), Expect = 3.1
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
++++++F+V+ E W+E M+ M+ A F++++++G+ ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 338 bits (866), Expect = 5e-92
Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ + A+A G LG ++ LR LR
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
Query: 1338 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388
D + N S+C A RW + K NFDN+G +SL +A+ GW++IMY
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
Query: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
Query: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506
EE K ++K K + P + ++ T DI I +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
Query: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566
E +Q + L + N +F +F E VLKL++ +F WN D +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
Query: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
Query: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686
L+ FIYA G+ F + G+ FE FG + + LFQ++T W+G++
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
Query: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
L DC D+ SS++ V +FVS+++ + V++N+ +AV++++ +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
Query: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760
+E+ E +E D E+ E+ P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
Score = 143 bits (360), Expect = 2e-33
Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
+W C W + + + +V + + I + I++NT+ M +EH+ E+ +++L + N+V
Sbjct: 738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
Query: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738
FT +F EM LK+ A + Y + +NIFD IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 791
KL + P L + ++ ++ + ++L + +FIF+++GM +FG CK S
Sbjct: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
Query: 792 TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 850
D R + + + VF++L E W +++ M L F+ +M GN
Sbjct: 916 ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Query: 851 YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
V+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 972 LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
Score = 130 bits (328), Expect = 1e-29
Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)
Query: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
A + L R IK++ + F + M IL NCV + M P D K ++
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
I+ F E ++K++A G + +L D WN LDF ++ V +DL N+ SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+RT RVLR LK I+ +P ++ +V L+ ++ L +V++L F +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
N+C + PP E + F + NG + E
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
K Y F G+ D G + + +C NP+ G +FD +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
T + W + + A I+F+L+I +GSF++INL L V+A + +E
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
K+ E + MLEQ +Q ++ A+ AE D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
Score = 112 bits (280), Expect = 4e-24
Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)
Query: 1454 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1502
+ LE+ R+K Y +A C + L++ + ++D+ IT I LN +
Sbjct: 715 MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
Query: 1503 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1562
M++EHY + L N +FT +F E LK++A +F++ WN D IV LS
Sbjct: 775 FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
Query: 1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1622
+M + L +E + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 835 LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
Query: 1623 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
L+ ++ FI+A +G++LFGK VC N CE H +F +FL +F+V G+
Sbjct: 885 TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
Query: 1679 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
W +T+ DC + CL+ F+ ++ V++N+ +A+L+
Sbjct: 943 -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Query: 1737 NKEAQED 1743
N A +D
Sbjct: 990 NLAATDD 996
Score = 102 bits (255), Expect = 3e-21
Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E T ++ N +F +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+G+D +NF+ G +++ LF + + GW ++ L++
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P +H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213
P + + L ++ D + I LN + +A+E P E S+ L+V N +FT
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
Query: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273
IF EM LK++++ Y+ Y + WN+ DGF+V +S++++ LA+ G L V
Sbjct: 801 IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
Query: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
LR R LR ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF +
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393
C+ I+N DC RW H D L+ VL + W+ M++ ++
Sbjct: 909 ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
Query: 1394 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L F+ ++I + VLN+F+ +++ +F
Sbjct: 955 G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
Score = 97.1 bits (240), Expect = 2e-19
Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)
Query: 569 STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 622
S++S E S +A E + +G E+ EE E +A + V + C
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 623 --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 672
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 673 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 727
E + VFT +F LEM+LK A+G Y N + D +IV +S+ + A G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 728 SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787
LRT R LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 788 F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 821
F + TG+ + NFD++ +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
Query: 822 DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 871
W ++Y + S + + LYFV + FG++ NL + ++++ F +
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
Query: 872 NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ + +D + EE K + G K PIP N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
Score = 95.9 bits (237), Expect = 4e-19
Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R L I+ H LF+ +++ I NC+ + + P + E
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ + + V L
Sbjct: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Query: 1329 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377
G + CL N N D + +N+D + + L
Sbjct: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
Query: 1378 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1410
+ +G++ N Y D + + + + W LY
Sbjct: 331 GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
Query: 1411 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454
I F+L++ SF+++N+ + VV + + Q +EAE+ ++ L
Sbjct: 391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
Query: 1455 RRLEKKRRKAQ 1465
+L+K++ +AQ
Sbjct: 451 EQLKKQQEEAQ 461
Score = 95.9 bits (237), Expect = 4e-19
Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 30 SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
S S + P +G P V P L P A F C+R+ + R
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
Query: 71 WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
C K+V + WFE + +ILL+ L + K + + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
Query: 130 MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
M+LK VA +G + Y + W LDF IV +V + + + + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
Query: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
L+A++R MR++VN LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
Score = 95.9 bits (237), Expect = 4e-19
Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q +E+TNIL N+VF +F E +LKL +
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 894
V+ N+ +A+++E F + + ED ++ EF KL +
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
Query: 895 LDSSGDPKLCPIP 907
D+ P L P
Sbjct: 1822 ADALDPPLLIAKP 1834
Score = 70.5 bits (171), Expect = 2e-11
Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
FN IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
Query: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
+LR+P+N D ++I + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 757 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
+++ ++ +L + + +F+++G+ +F +LR PD +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
Score = 69.7 bits (169), Expect = 3e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
+V +P+ + + I+LN + + M + +L V + F EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
+A+ + Y + WN D FIV ++E L L N+ LS +R+ R+LR K P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
Query: 254 PPYY 257
P ++
Sbjct: 921 PRWH 924
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT M DD + IL + + F E VLK+++L +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1774
F LIN+++AV+ ++ N+ E+AE +AE + LE + + A R
Sbjct: 413 SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Query: 1775 GPGGAGGGG 1783
GAGG G
Sbjct: 473 DFSGAGGIG 481
Score = 48.1 bits (113), Expect = 9e-05
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
Query: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893
++ + A +++ ++ +E+ K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
Score = 33.1 bits (74), Expect = 3.1
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
++++++F+V+ E W+E M+ M+ A F++++++G+ ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 338 bits (866), Expect = 5e-92
Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219
R C I+ H F+ ++ I L+ +A E IE T + L ++ +FT IF+ EM
Sbjct: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
Query: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279
LK V+ +G Q Y ++W LD +V VS++ + A+A G LG ++ LR LR
Sbjct: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
Query: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GKFYHC+
Sbjct: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
Query: 1338 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388
D + N S+C A RW + K NFDN+G +SL +A+ GW++IMY
Sbjct: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
Query: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448
+D+ V+ QP N +M LYF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
Query: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506
EE K ++K K + P + ++ T DI I +ICLN+VTM +
Sbjct: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
Query: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566
E +Q + L + N +F +F E VLKL++ +F WN D +V+LS++G+
Sbjct: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
Query: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626
L E+ ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
Query: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686
L+ FIYA G+ F + G+ FE FG + + LFQ++T W+G++
Sbjct: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
Query: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
L DC D+ SS++ V +FVS+++ + V++N+ +AV++++ +
Sbjct: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
Query: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760
+E+ E +E D E+ E+ P
Sbjct: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
Score = 143 bits (360), Expect = 2e-33
Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)
Query: 619 VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678
+W C W + + + +V + + I + I++NT+ M +EH+ E+ +++L + N+V
Sbjct: 738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
Query: 679 FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738
FT +F EM LK+ A + Y + +NIFD IV +S+ E+ GLSVLR+FRLLRV
Sbjct: 798 FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
Query: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 791
KL + P L + ++ ++ + ++L + +FIF+++GM +FG CK S
Sbjct: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
Query: 792 TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 850
D R + + + VF++L E W +++ M L F+ +M GN
Sbjct: 916 ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Query: 851 YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896
V+ NL +A+L+ F ++ N + +D+D +N++ ++Q+G+D
Sbjct: 972 LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
Score = 130 bits (328), Expect = 1e-29
Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)
Query: 58 AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117
A + L R IK++ + F + M IL NCV + M P D K ++
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
Query: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176
I+ F E ++K++A G + +L D WN LDF ++ V +DL N+ SA
Sbjct: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
Query: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+RT RVLR LK I+ +P ++ +V L+ ++ L +V++L F +F +IG+QL+ G LR
Sbjct: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
Query: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296
N+C + PP E + F + NG + E
Sbjct: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
Query: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354
K Y F G+ D G + + +C NP+ G +FD +A++ +F+++
Sbjct: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
Query: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404
T + W + + A I+F+L+I +GSF++INL L V+A + +E
Sbjct: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
Query: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433
K+ E + MLEQ +Q ++ A+ AE D
Sbjct: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
Score = 112 bits (280), Expect = 4e-24
Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)
Query: 1454 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1502
+ LE+ R+K Y +A C + L++ + ++D+ IT I LN +
Sbjct: 715 MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
Query: 1503 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1562
M++EHY + L N +FT +F E LK++A +F++ WN D IV LS
Sbjct: 775 FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
Query: 1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1622
+M + L +E + ++R R+ RV KL K + L+ + ++ +GNL
Sbjct: 835 LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
Query: 1623 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678
L+ ++ FI+A +G++LFGK VC N CE H +F +FL +F+V G+
Sbjct: 885 TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
Query: 1679 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736
W +T+ DC + CL+ F+ ++ V++N+ +A+L+
Sbjct: 943 -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
Query: 1737 NKEAQED 1743
N A +D
Sbjct: 990 NLAATDD 996
Score = 102 bits (255), Expect = 3e-21
Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214
P N+F+ + + ++FD ++ I LN +T+ +E T ++ N +F +
Sbjct: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
Query: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274
F GE LK++SL Y Y WN+ D +V +SI+ + ++ + RV+
Sbjct: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
Query: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334
RL R R LR+I A G++ ++ L+ SL + NI L+ I+ I G+ F
Sbjct: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
Query: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394
+G+D +NF+ G +++ LF + + GW ++ L++
Sbjct: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
Query: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434
D P +H NP + + +F+S+++I V+NM++ V++ENF
Sbjct: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)
Query: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213
P + + L ++ D + I LN + +A+E P E S+ L+V N +FT
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
Query: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273
IF EM LK++++ Y+ Y + WN+ DGF+V +S++++ LA+ G L V
Sbjct: 801 IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
Query: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333
LR R LR ++ P L ++++ + +S+ +GN+ L+ IF ++G+QLF +
Sbjct: 849 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
Query: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393
C+ I+N DC RW H D L+ VL + W+ M++ ++
Sbjct: 909 ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
Query: 1394 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434
L F+ ++I + VLN+F+ +++ +F
Sbjct: 955 G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
Score = 97.1 bits (240), Expect = 2e-19
Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)
Query: 569 STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 622
S++S E S +A E + +G E+ EE E +A + V + C
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 623 --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 672
G +W R IV+ +F I+ IL+++ ++ E + EQ + + +L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 673 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 727
E + VFT +F LEM+LK A+G Y N + D +IV +S+ + A G +
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 728 SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787
LRT R LR L+ + +R + L+ + ++ ++ ++F IFSI+G+++F K
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 788 F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 821
F + TG+ + NFD++ +++ Q+ T +
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
Query: 822 DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 871
W ++Y + S + + LYFV + FG++ NL + ++++ F +
Sbjct: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
Query: 872 NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911
+ + +D + EE K + G K PIP N
Sbjct: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
Score = 95.9 bits (237), Expect = 4e-19
Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)
Query: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208
++Y+ +P N R L I+ H LF+ +++ I NC+ + + P + E
Sbjct: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
Query: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268
Y FT I+ E +K+++ G + +LR WN LD ++ + + V L
Sbjct: 160 YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
Query: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328
G + LR R LR L+ IS PGLK +V LI S+K + +++++ +F ++G+QLF
Sbjct: 211 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
Query: 1329 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377
G + CL N N D + +N+D + + L
Sbjct: 271 MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
Query: 1378 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1410
+ +G++ N Y D + + + + W LY
Sbjct: 331 GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
Query: 1411 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454
I F+L++ SF+++N+ + VV + + Q +EAE+ ++ L
Sbjct: 391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
Query: 1455 RRLEKKRRKAQ 1465
+L+K++ +AQ
Sbjct: 451 EQLKKQQEEAQ 461
Score = 95.9 bits (237), Expect = 4e-19
Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)
Query: 30 SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70
S S + P +G P V P L P A F C+R+ + R
Sbjct: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
Query: 71 WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129
C K+V + WFE + +ILL+ L + K + + D +F + F +E
Sbjct: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
Query: 130 MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185
M+LK VA +G + Y + W LDF IV +V + + + + ++RT+R LRP
Sbjct: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
Query: 186 LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
L+A++R MR++VN LL +P + NVLL+C + IF I+GV L+AG
Sbjct: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
Score = 95.9 bits (237), Expect = 4e-19
Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)
Query: 637 VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696
V + F+ IM+ I +N V+M +E +Q +E+TNIL N+VF +F E +LKL +
Sbjct: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
Query: 697 FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748
+ Y +NIFD ++VI+SI E++ + + V+R R+ R+L+L++ +
Sbjct: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
Query: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808
R L LM ++ + +LL L +FI++I GM F ++ + G + D NF++
Sbjct: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
Query: 809 WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847
+++ +FQI T W+ +L + S P +FV+ +
Sbjct: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
Query: 848 FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 894
V+ N+ +A+++E F + + ED ++ EF KL +
Sbjct: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
Query: 895 LDSSGDPKLCPIP 907
D+ P L P
Sbjct: 1822 ADALDPPLLIAKP 1834
Score = 70.5 bits (171), Expect = 2e-11
Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697
FN IM IL N V M + + P + T +E FT ++ E ++K+ A G F
Sbjct: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
Query: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756
+LR+P+N D ++I + E V G +S LRTFR+LR LK + +P L+ + L+
Sbjct: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
Query: 757 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805
+++ ++ +L + + +F+++G+ +F +LR PD +F+
Sbjct: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
Score = 69.7 bits (169), Expect = 3e-11
Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)
Query: 338 INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387
+NFDN+G ++ + QV T +GW++IMY +D+ + Y ++YF++ II GSF
Sbjct: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
Query: 388 FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422
F +NL + VI F++ K++ + M E++++Y ++
Sbjct: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
Score = 66.6 bits (161), Expect = 3e-10
Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134
+V +P+ + + I+LN + + M + +L V + F EM LK+
Sbjct: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
Query: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193
+A+ + Y + WN D FIV ++E L L N+ LS +R+ R+LR K P
Sbjct: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253
++ +L+ ++ +++ LGN+ L+ + FIF ++G+QL+ + + E I D L
Sbjct: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
Query: 254 PPYY 257
P ++
Sbjct: 921 PRWH 924
Score = 57.0 bits (136), Expect = 2e-07
Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)
Query: 81 FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140
F+ M++I LN VT M DD + IL + + F E VLK+++L +
Sbjct: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
Query: 141 GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193
Y WN DF +V+ +V L + IR R+ R L+ I
Sbjct: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
Query: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236
+R L+ L+ +LP L N+ LL F V FI+ I G+ +A + R
Sbjct: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Score = 49.7 bits (117), Expect = 3e-05
Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717
+ +F+ F AFL+LF++ T D W + + TLR + ++FV +
Sbjct: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
Query: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1774
F LIN+++AV+ ++ N+ E+AE +AE + LE + + A R
Sbjct: 413 SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
Query: 1775 GPGGAGGGG 1783
GAGG G
Sbjct: 473 DFSGAGGIG 481
Score = 48.1 bits (113), Expect = 9e-05
Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)
Query: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862
+FD+ WA +++F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
Query: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893
++ + A +++ ++ +E+ K QE
Sbjct: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
Score = 33.1 bits (74), Expect = 3.1
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402
++++++F+V+ E W+E M+ M+ A F++++++G+ ++NL L ++ + FS
Sbjct: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 337 bits (864), Expect = 8e-92
Identities = 205/647 (31%), Positives = 357/647 (55%), Gaps = 52/647 (8%)
Query: 1117 EDEEEIDYTLCFRVRKMIDVY-KPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1175
EDEEE + + R R + +++ K + E + ++FS NRFR+ C I+ +F +
Sbjct: 846 EDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905
Query: 1176 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1235
+L FI L+ I++A E P ++ S L ++Y+FT+IF E+ LK+ + G + + ++
Sbjct: 906 ILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 1236 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1295
R+ +N+LD +V VS+I + ++ + V+++LR+LR LRPLR I+RA GLK V
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSA------INVVKILRVLRVLRPLRAINRAKGLKHV 1018
Query: 1296 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANY- 1354
V+ + +++ IGNIV++ +F +GVQLFKGK Y C + ++C NY
Sbjct: 1019 VQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAEC-KGNYI 1074
Query: 1355 ---------------RWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQP 1399
W + K++FDN+ A+M+LF +++ +GW ++Y +D+ D+ P
Sbjct: 1075 TYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1134
Query: 1400 VTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE-EKRLRRLE 1458
+ N+ + ++FI +++I++FF++N+FVG V+ F Q Q +E + E +K R+
Sbjct: 1135 IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QEQGEQEYKNCELDKNQRQCV 1190
Query: 1459 KKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETA 1518
+ KA+ L Y + + + S Y + + +I LN + ++++HY Q + A
Sbjct: 1191 EYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIA 1250
Query: 1519 LKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALP 1578
+ N +FT +F +E +LKL+AF + +F D WN D IV+ S++ I + E+N A
Sbjct: 1251 MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEE 1308
Query: 1579 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGV 1638
+ I R+ R+ R++KLL G+R LL T +++ + + LL ++LFFIYA +G+
Sbjct: 1309 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1368
Query: 1639 ELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM-----------KDT 1687
++FGK+ ND ++R+ F+ F A L LF+ +TG+ W IM +
Sbjct: 1369 QVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1425
Query: 1688 LRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1734
+ T E C SS + YF+SF + F++IN+ VAV+M + D
Sbjct: 1426 PSNSTEGETPCGSSF---AVFYFISFYMLCAFLIINLFVAVIMDNFD 1469
Score = 172 bits (437), Expect = 3e-42
Identities = 124/404 (30%), Positives = 194/404 (48%), Gaps = 83/404 (20%)
Query: 56 PIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKIL 115
P A CL R CI +V FE + +L I NCV L +Y P + D + +
Sbjct: 101 PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE 160
Query: 116 QVFDDFIF-IFFAMEMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-- 171
+V +++F I F +E LK++A G+ F YL + WN LDF IV+ G+ L+
Sbjct: 161 RV--EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA 218
Query: 172 ------------INLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFV 219
++ A+R RVLRPL+ ++ VPS+++++N ++ + L ++ LL FV
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 220 FFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMG 279
I+ IIG++L+ G + C+ +E DV P EDD P C+L
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGI---ADV-------PAEDDPSP--CAL-------- 318
Query: 280 CHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN 339
+ G GRQ N + VC+ G P G N
Sbjct: 319 ----------------------ETGHGRQCQNGT-----------VCKPGWDGPKHGITN 345
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIA 398
FDN +A + +FQ IT+EGW +++Y+V DA + +IYF+ LII+GSFF++NL L V++
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLS 405
Query: 399 TQFSETKQ-----------REHRLMLEQRQRYLSSSTVASYAEP 431
+FS+ ++ RE + + E + YL T A +P
Sbjct: 406 GEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 449
Score = 160 bits (405), Expect = 1e-38
Identities = 110/358 (30%), Positives = 178/358 (49%), Gaps = 44/358 (12%)
Query: 560 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV 619
D +P + S E + + AGG+ E + GAR + + S+ +
Sbjct: 457 DEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSR------------ 504
Query: 620 WLCGDVWRE----TRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 675
WR R K R V S F ++ + +NT+++ EH+ QP LT + +
Sbjct: 505 -----YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 676 NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG-----QADGGLSVL 730
N ++F EM+LK+ + GL Y + +N FD +V I E + + G+SVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL 790
R RLLR+ K+ R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM +FG KF+
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 791 RTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG-MASTSP-----WASLYFVA 844
+ R FD+ +++TVFQILT EDWN V+Y+G MA P +YF+
Sbjct: 680 ----DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFII 735
Query: 845 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK 902
L GNY+L N+ +AI V+ N + ++ S+ EE +K ++ L + P+
Sbjct: 736 LFICGNYILLNVFLAIAVD--------NLADAESLTSAQKEEEEEKERKKLARTASPE 785
Score = 154 bits (388), Expect = 1e-36
Identities = 110/348 (31%), Positives = 176/348 (50%), Gaps = 53/348 (15%)
Query: 1156 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN-----YI 1210
+N R C +I+ K F+ ++L IF NC+ +A+ P E S T SN Y+
Sbjct: 110 KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA----TNSNLERVEYL 165
Query: 1211 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLAS-AGGAKILG 1269
F IF E LKV++ GL F AYLR+ WN+LD +V V + ++ A+ A GA LG
Sbjct: 166 FLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALG 225
Query: 1270 V------LRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL 1323
++ LR R LRPLR++S P L++V+ ++I ++ P+ +I L+ II+ I+
Sbjct: 226 GKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAII 285
Query: 1324 GVQLFKGKF----YHCLGVDT-----------------RNITNRSDCMAANYRWVHHKYN 1362
G++LF GK Y+ G+ R N + C H N
Sbjct: 286 GLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITN 345
Query: 1363 FDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV 1422
FDN A++++F + +GW +++Y DAV D W +YF++ ++I SFFV
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFV 396
Query: 1423 LNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYY 1470
LN+ +GV+ F K E E+A+ R + ++L +K++ + L Y
Sbjct: 397 LNLVLGVLSGEFSK-----EREKAKARGD--FQKLREKQQLEEDLKGY 437
Score = 122 bits (307), Expect = 3e-27
Identities = 73/259 (28%), Positives = 138/259 (53%), Gaps = 16/259 (6%)
Query: 1493 ITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWN 1552
+ F++ LN +T++ EHYNQP L N +F E +LK+ + GL+ +F +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 1553 QLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1612
+ D +V ++ L E +I ++P I ++R +R+ R+ K+ + + L+ ++
Sbjct: 590 RFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 1613 VQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLF 1672
+ ++ + +L LL L I++ LG++LFG DE +R +TF+NF + LT+F
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM----QTRRSTFDNFPQSLLTVF 700
Query: 1673 QVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH 1732
Q+ TG++WN +M D + + S L + YF+ + ++L+NV +A+ + +
Sbjct: 701 QILTGEDWNSVMYDGI--MAYGGPSFPGMLVCI---YFIILFICGNYILLNVFLAIAVDN 755
Query: 1733 LDDSNK--EAQEDAEMDAE 1749
L D+ AQ++ E + E
Sbjct: 756 LADAESLTSAQKEEEEEKE 774
Score = 120 bits (300), Expect = 2e-26
Identities = 94/316 (29%), Positives = 156/316 (49%), Gaps = 38/316 (12%)
Query: 1157 NRF-RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1215
NRF R C+ + +F ++V+ +FLN +TIA E TE +N A+F
Sbjct: 510 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTE--VQDTANKALLALF 567
Query: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
EM LK+ SLGL QAY S +N D F+V I++ ++ + VLR +R
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVR 623
Query: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
LLR + R + L +V +L++S++ I +++L+ F IIF +LG+QLF GKF +
Sbjct: 624 LLRIFKITRYWN---SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Query: 1336 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1395
+ TR T FDN Q+L+++F + + + W ++MY+G+ A
Sbjct: 680 DEMQTRRST------------------FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 721
Query: 1396 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCR-----QHQEAEEARRRE 1450
P + +YFI + ++ +LN+F+ + V+N Q +E EE R++
Sbjct: 722 PSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKK 777
Query: 1451 EKRLRRLEKKRRKAQR 1466
R EKK+ ++
Sbjct: 778 LARTASPEKKQELVEK 793
Score = 107 bits (268), Expect = 1e-22
Identities = 78/303 (25%), Positives = 150/303 (49%), Gaps = 41/303 (13%)
Query: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET-ALKYCNYMFTTVFVLEAV 1535
RL H + I F I L+ ++++ E Q TS L +Y+FT++F LE +
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEII 949
Query: 1536 LKLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1591
LK+ A+G F ++ +N LDL +V +S++ ++ IN +++I+RVLR
Sbjct: 950 LKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN--------VVKILRVLR 1001
Query: 1592 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL-VCND- 1648
+ R L+ + A G++ ++ V A+ +GN+ ++ LL F++A +GV+LF GKL C+D
Sbjct: 1002 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061
Query: 1649 ----ENPCEGM--------------------SRHATFENFGMAFLTLFQVSTGDNWNGIM 1684
E C+G + F+N A + LF VST + W ++
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121
Query: 1685 KDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDA 1744
++ T D+ + +S ++F+ +++ F ++N+ V ++ + ++ ++
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEIS-IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC 1180
Query: 1745 EMD 1747
E+D
Sbjct: 1181 ELD 1183
Score = 107 bits (267), Expect = 1e-22
Identities = 70/257 (27%), Positives = 131/257 (50%), Gaps = 30/257 (11%)
Query: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
+V+S YF + + IL+NT+ + ++H+ Q + I N++FT +F +EMILKL AF
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 696 LFDYLRNPYNIFDSIIVIISIWEI----VGQADG----GLSVLRTFRLLRVLKLVRFMPA 747
Y + +N FD++IV+ SI +I V A+ ++ R FR++R++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 748 LRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSL 807
+R L +K+ + +L+++ FI++++GM +FG K +L T + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIALNDTT--EINRNNNFQTF 1391
Query: 808 LWAIVTVFQILTQEDWNVVLYNGMAST-------------------SPWASLYFVALMTF 848
A++ +F+ T E W ++ M S +A YF++
Sbjct: 1392 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1451
Query: 849 GNYVLFNLLVAILVEGF 865
+++ NL VA++++ F
Sbjct: 1452 CAFLIINLFVAVIMDNF 1468
Score = 103 bits (257), Expect = 2e-21
Identities = 92/337 (27%), Positives = 154/337 (45%), Gaps = 69/337 (20%)
Query: 621 LCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNI----LEICN 676
LC + R IV+ K F I++ I N V++ I + PE+ +N LE
Sbjct: 105 LCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVE 163
Query: 677 VVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISIWEIV----GQADGG-- 726
+F +F +E LK+ A+GL YLRN +N+ D IIV++ ++ + +ADG
Sbjct: 164 YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANA 223
Query: 727 ---------LSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 777
+ LR FR+LR L+LV +P+L+ L ++K M + +L++ I I++
Sbjct: 224 LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 283
Query: 778 ILGMHIFGCKF----------------------SLRTDTGDTVPDR-------------- 801
I+G+ +F K +L T G +
Sbjct: 284 IIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGI 343
Query: 802 KNFDSLLWAIVTVFQILTQEDWNVVLY---NGMASTSPWASLYFVALMTFGNYVLFNLLV 858
NFD+ +A++TVFQ +T E W VLY + + PW +YFV L+ G++ + NL++
Sbjct: 344 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW--IYFVTLIIIGSFFVLNLVL 401
Query: 859 AILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGL 895
+L F E + ++ D + E +L+E L
Sbjct: 402 GVLSGEFSKEREKAKARGD----FQKLREKQQLEEDL 434
Score = 92.8 bits (229), Expect = 3e-18
Identities = 77/351 (21%), Positives = 150/351 (42%), Gaps = 44/351 (12%)
Query: 582 SAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKY 641
+ G EDE + + SEL +E+ + + + R + IV+
Sbjct: 842 TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTN-ILEICNVVFTSMFALEMILKLAAFGLF--- 697
F I+ IL++++S+ E Q N IL + VFTS+F LE+ILK+ A+G F
Sbjct: 902 FTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHK 961
Query: 698 -DYLRNPYNIFDSIIVIISI--WEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVV 754
+ RN +NI D ++V +S+ + I A + +LR R+LR L+ + L+ +
Sbjct: 962 GSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 755 LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVP--------------- 799
+ + + ++ L F+F+ +G+ +F K +D+
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEV 1081
Query: 800 ------------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSP----------W 837
+ +FD++L A++ +F + T E W +LY + S +
Sbjct: 1082 DHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVE 1141
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEF 888
S++F+ + + + N+ V ++ FQ +G+ + D++ E+
Sbjct: 1142 ISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY 1192
Score = 88.6 bits (218), Expect = 6e-17
Identities = 71/243 (29%), Positives = 113/243 (46%), Gaps = 21/243 (8%)
Query: 3 ESASPPSSSAAAPAAEPGVTTEQP--------GPRSPPSSPPGLEEPLDGADPHVPHPDL 54
+ P + +P P T E+ GPR P S L+E VP P+
Sbjct: 824 DDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKA------VPMPEA 877
Query: 55 APIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKI 114
+ AFF R C ++V + F + + ILL+ ++L P S R I
Sbjct: 878 S--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT---SFRNHI 932
Query: 115 LQVFDDFIFIFFAMEMVLKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN 173
L D F +E++LKM A G F K + + +N LD +V ++ + + IN
Sbjct: 933 LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992
Query: 174 LSAI-RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+ I R +RVLRPL+AINR ++ +V + + +GN++++ + F+F IGVQL+
Sbjct: 993 VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052
Query: 233 GLL 235
G L
Sbjct: 1053 GKL 1055
Score = 84.0 bits (206), Expect = 2e-15
Identities = 68/300 (22%), Positives = 136/300 (45%), Gaps = 58/300 (19%)
Query: 1490 DIFITFIICLNVVTMSLE---HYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGL--- 1543
+I I I N V +++ + + + L+ Y+F +F +EA LK++A+GL
Sbjct: 127 EIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFH 186
Query: 1544 -RRFFKDRWNQLDLAIVLLSVMGITLEEI-EINAALPINPT----IIRIMRVLRIARVLK 1597
+ ++ WN LD IV++ + LE+ + + A + ++ +R R+ R L+
Sbjct: 187 PNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR 246
Query: 1598 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL--VC-------- 1646
L+ ++ +L+++++A+ + ++ LL + + IYA +G+ELF GK+ C
Sbjct: 247 LVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAD 306
Query: 1647 ----NDENPCEGMSRH---------------------ATFENFGMAFLTLFQVSTGDNWN 1681
+D +PC + H F+NF A LT+FQ T + W
Sbjct: 307 VPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWT 366
Query: 1682 GIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQ 1741
++ + D + +YFV+ ++ F ++N+V+ VL ++A+
Sbjct: 367 DVLY-WVNDAVGRDWPW---------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Score = 68.9 bits (167), Expect = 5e-11
Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 16/171 (9%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
+V + +FE + ++ILLN + L M CL KI + +F F +EM+LK
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLF---KIAMNILNMLFTGLFTVEMILK 1269
Query: 134 MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-------INLSAIRTVRVLRPL 186
++A F K Y D WN D IV+ +V+ ++ N I+++ R RV+R +
Sbjct: 1270 LIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLV 1326
Query: 187 KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237
K ++R +R L+ + + L V LL +FFI+ +IG+Q++ + N
Sbjct: 1327 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.5 bits (153), Expect = 2e-09
Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 7/116 (6%)
Query: 122 IFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD----LQNINLSAI 177
+ F EM+LKM +LG+ + Y +NR D F+V G++E L + + +S +
Sbjct: 563 LLALFTAEMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 178 RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
R VR+LR K S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 57.4 bits (137), Expect = 2e-07
Identities = 31/91 (34%), Positives = 55/91 (60%), Gaps = 11/91 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHS-----FYNF-----IYFILLIIVGSFF 388
+FDN+ A + +F V T EGW E++Y +D+H+ YN+ I+FI+ II+ +FF
Sbjct: 1097 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 1156
Query: 389 MINLCLVVIATQFSETKQREHR-LMLEQRQR 418
M+N+ + + F E ++E++ L++ QR
Sbjct: 1157 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1187
Score = 44.3 bits (103), Expect = 0.001
Identities = 21/72 (29%), Positives = 40/72 (55%), Gaps = 6/72 (8%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF------IYFILLIIVGSFFMINLC 393
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 394 LVVIATQFSETK 405
L + ++ +
Sbjct: 749 LAIAVDNLADAE 760
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 337 bits (864), Expect = 8e-92
Identities = 205/647 (31%), Positives = 357/647 (55%), Gaps = 52/647 (8%)
Query: 1117 EDEEEIDYTLCFRVRKMIDVY-KPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYV 1175
EDEEE + + R R + +++ K + E + ++FS NRFR+ C I+ +F +
Sbjct: 846 EDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905
Query: 1176 VLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAY 1235
+L FI L+ I++A E P ++ S L ++Y+FT+IF E+ LK+ + G + + ++
Sbjct: 906 ILFFILLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSF 964
Query: 1236 LRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1295
R+ +N+LD +V VS+I + ++ + V+++LR+LR LRPLR I+RA GLK V
Sbjct: 965 CRNYFNILDLLVVSVSLISFGIQSSA------INVVKILRVLRVLRPLRAINRAKGLKHV 1018
Query: 1296 VETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANY- 1354
V+ + +++ IGNIV++ +F +GVQLFKGK Y C + ++C NY
Sbjct: 1019 VQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC---SDSSKQTEAEC-KGNYI 1074
Query: 1355 ---------------RWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQP 1399
W + K++FDN+ A+M+LF +++ +GW ++Y +D+ D+ P
Sbjct: 1075 TYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP 1134
Query: 1400 VTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRRE-EKRLRRLE 1458
+ N+ + ++FI +++I++FF++N+FVG V+ F Q Q +E + E +K R+
Sbjct: 1135 IYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTF----QEQGEQEYKNCELDKNQRQCV 1190
Query: 1459 KKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETA 1518
+ KA+ L Y + + + S Y + + +I LN + ++++HY Q + A
Sbjct: 1191 EYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIA 1250
Query: 1519 LKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALP 1578
+ N +FT +F +E +LKL+AF + +F D WN D IV+ S++ I + E+N A
Sbjct: 1251 MNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAI--TEVNNAEE 1308
Query: 1579 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGV 1638
+ I R+ R+ R++KLL G+R LL T +++ + + LL ++LFFIYA +G+
Sbjct: 1309 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1368
Query: 1639 ELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM-----------KDT 1687
++FGK+ ND ++R+ F+ F A L LF+ +TG+ W IM +
Sbjct: 1369 QVFGKIALNDTTE---INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE 1425
Query: 1688 LRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLD 1734
+ T E C SS + YF+SF + F++IN+ VAV+M + D
Sbjct: 1426 PSNSTEGETPCGSSF---AVFYFISFYMLCAFLIINLFVAVIMDNFD 1469
Score = 172 bits (437), Expect = 3e-42
Identities = 124/404 (30%), Positives = 194/404 (48%), Gaps = 83/404 (20%)
Query: 56 PIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKIL 115
P A CL R CI +V FE + +L I NCV L +Y P + D + +
Sbjct: 101 PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE 160
Query: 116 QVFDDFIF-IFFAMEMVLKMVALGI-FGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-- 171
+V +++F I F +E LK++A G+ F YL + WN LDF IV+ G+ L+
Sbjct: 161 RV--EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA 218
Query: 172 ------------INLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFV 219
++ A+R RVLRPL+ ++ VPS+++++N ++ + L ++ LL FV
Sbjct: 219 DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFV 278
Query: 220 FFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMG 279
I+ IIG++L+ G + C+ +E DV P EDD P C+L
Sbjct: 279 IIIYAIIGLELFMGKMHKTCYNQEGI---ADV-------PAEDDPSP--CAL-------- 318
Query: 280 CHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAIN 339
+ G GRQ N + VC+ G P G N
Sbjct: 319 ----------------------ETGHGRQCQNGT-----------VCKPGWDGPKHGITN 345
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIA 398
FDN +A + +FQ IT+EGW +++Y+V DA + +IYF+ LII+GSFF++NL L V++
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLS 405
Query: 399 TQFSETKQ-----------REHRLMLEQRQRYLSSSTVASYAEP 431
+FS+ ++ RE + + E + YL T A +P
Sbjct: 406 GEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP 449
Score = 160 bits (405), Expect = 1e-38
Identities = 110/358 (30%), Positives = 178/358 (49%), Gaps = 44/358 (12%)
Query: 560 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAV 619
D +P + S E + + AGG+ E + GAR + + S+ +
Sbjct: 457 DEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSR------------ 504
Query: 620 WLCGDVWRE----TRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEIC 675
WR R K R V S F ++ + +NT+++ EH+ QP LT + +
Sbjct: 505 -----YWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTA 559
Query: 676 NVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVG-----QADGGLSVL 730
N ++F EM+LK+ + GL Y + +N FD +V I E + + G+SVL
Sbjct: 560 NKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 731 RTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSL 790
R RLLR+ K+ R+ +L + L+ ++ ++A+ +LL LFI IFS+LGM +FG KF+
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNF 679
Query: 791 RTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNG-MASTSP-----WASLYFVA 844
+ R FD+ +++TVFQILT EDWN V+Y+G MA P +YF+
Sbjct: 680 ----DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFII 735
Query: 845 LMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK 902
L GNY+L N+ +AI V+ N + ++ S+ EE +K ++ L + P+
Sbjct: 736 LFICGNYILLNVFLAIAVD--------NLADAESLTSAQKEEEEEKERKKLARTASPE 785
Score = 154 bits (388), Expect = 1e-36
Identities = 110/348 (31%), Positives = 176/348 (50%), Gaps = 53/348 (15%)
Query: 1156 ENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN-----YI 1210
+N R C +I+ K F+ ++L IF NC+ +A+ P E S T SN Y+
Sbjct: 110 KNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNA----TNSNLERVEYL 165
Query: 1211 FTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLAS-AGGAKILG 1269
F IF E LKV++ GL F AYLR+ WN+LD +V V + ++ A+ A GA LG
Sbjct: 166 FLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALG 225
Query: 1270 V------LRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGIL 1323
++ LR R LRPLR++S P L++V+ ++I ++ P+ +I L+ II+ I+
Sbjct: 226 GKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAII 285
Query: 1324 GVQLFKGKF----YHCLGVDT-----------------RNITNRSDCMAANYRWVHHKYN 1362
G++LF GK Y+ G+ R N + C H N
Sbjct: 286 GLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITN 345
Query: 1363 FDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV 1422
FDN A++++F + +GW +++Y DAV D W +YF++ ++I SFFV
Sbjct: 346 FDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFV 396
Query: 1423 LNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYY 1470
LN+ +GV+ F K E E+A+ R + ++L +K++ + L Y
Sbjct: 397 LNLVLGVLSGEFSK-----EREKAKARGD--FQKLREKQQLEEDLKGY 437
Score = 122 bits (307), Expect = 3e-27
Identities = 73/259 (28%), Positives = 138/259 (53%), Gaps = 16/259 (6%)
Query: 1493 ITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWN 1552
+ F++ LN +T++ EHYNQP L N +F E +LK+ + GL+ +F +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 1553 QLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTV 1612
+ D +V ++ L E +I ++P I ++R +R+ R+ K+ + + L+ ++
Sbjct: 590 RFDCFVVCGGILETILVETKI-----MSPLGISVLRCVRLLRIFKITRYWNSLSNLVASL 644
Query: 1613 VQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLF 1672
+ ++ + +L LL L I++ LG++LFG DE +R +TF+NF + LT+F
Sbjct: 645 LNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM----QTRRSTFDNFPQSLLTVF 700
Query: 1673 QVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKH 1732
Q+ TG++WN +M D + + S L + YF+ + ++L+NV +A+ + +
Sbjct: 701 QILTGEDWNSVMYDGI--MAYGGPSFPGMLVCI---YFIILFICGNYILLNVFLAIAVDN 755
Query: 1733 LDDSNK--EAQEDAEMDAE 1749
L D+ AQ++ E + E
Sbjct: 756 LADAESLTSAQKEEEEEKE 774
Score = 120 bits (300), Expect = 2e-26
Identities = 94/316 (29%), Positives = 156/316 (49%), Gaps = 38/316 (12%)
Query: 1157 NRF-RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1215
NRF R C+ + +F ++V+ +FLN +TIA E TE +N A+F
Sbjct: 510 NRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTE--VQDTANKALLALF 567
Query: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275
EM LK+ SLGL QAY S +N D F+V I++ ++ + VLR +R
Sbjct: 568 TAEMLLKMYSLGL----QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVR 623
Query: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335
LLR + R + L +V +L++S++ I +++L+ F IIF +LG+QLF GKF +
Sbjct: 624 LLRIFKITRYWN---SLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Query: 1336 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1395
+ TR T FDN Q+L+++F + + + W ++MY+G+ A
Sbjct: 680 DEMQTRRST------------------FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGG 721
Query: 1396 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCR-----QHQEAEEARRRE 1450
P + +YFI + ++ +LN+F+ + V+N Q +E EE R++
Sbjct: 722 PSFP----GMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKK 777
Query: 1451 EKRLRRLEKKRRKAQR 1466
R EKK+ ++
Sbjct: 778 LARTASPEKKQELVEK 793
Score = 107 bits (268), Expect = 1e-22
Identities = 78/303 (25%), Positives = 150/303 (49%), Gaps = 41/303 (13%)
Query: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLET-ALKYCNYMFTTVFVLEAV 1535
RL H + I F I L+ ++++ E Q TS L +Y+FT++F LE +
Sbjct: 890 RLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEII 949
Query: 1536 LKLVAFGL----RRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1591
LK+ A+G F ++ +N LDL +V +S++ ++ IN +++I+RVLR
Sbjct: 950 LKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN--------VVKILRVLR 1001
Query: 1592 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL-VCND- 1648
+ R L+ + A G++ ++ V A+ +GN+ ++ LL F++A +GV+LF GKL C+D
Sbjct: 1002 VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDS 1061
Query: 1649 ----ENPCEGM--------------------SRHATFENFGMAFLTLFQVSTGDNWNGIM 1684
E C+G + F+N A + LF VST + W ++
Sbjct: 1062 SKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELL 1121
Query: 1685 KDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDA 1744
++ T D+ + +S ++F+ +++ F ++N+ V ++ + ++ ++
Sbjct: 1122 YRSIDSHTEDKGPIYNYRVEIS-IFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNC 1180
Query: 1745 EMD 1747
E+D
Sbjct: 1181 ELD 1183
Score = 107 bits (267), Expect = 1e-22
Identities = 70/257 (27%), Positives = 131/257 (50%), Gaps = 30/257 (11%)
Query: 636 IVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFG 695
+V+S YF + + IL+NT+ + ++H+ Q + I N++FT +F +EMILKL AF
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFK 1274
Query: 696 LFDYLRNPYNIFDSIIVIISIWEI----VGQADG----GLSVLRTFRLLRVLKLVRFMPA 747
Y + +N FD++IV+ SI +I V A+ ++ R FR++R++KL+
Sbjct: 1275 PKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEG 1334
Query: 748 LRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSL 807
+R L +K+ + +L+++ FI++++GM +FG K +L T + NF +
Sbjct: 1335 IRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFG-KIALNDTT--EINRNNNFQTF 1391
Query: 808 LWAIVTVFQILTQEDWNVVLYNGMAST-------------------SPWASLYFVALMTF 848
A++ +F+ T E W ++ M S +A YF++
Sbjct: 1392 PQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYML 1451
Query: 849 GNYVLFNLLVAILVEGF 865
+++ NL VA++++ F
Sbjct: 1452 CAFLIINLFVAVIMDNF 1468
Score = 103 bits (257), Expect = 2e-21
Identities = 92/337 (27%), Positives = 154/337 (45%), Gaps = 69/337 (20%)
Query: 621 LCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNI----LEICN 676
LC + R IV+ K F I++ I N V++ I + PE+ +N LE
Sbjct: 105 LCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAI-YIPFPEDDSNATNSNLERVE 163
Query: 677 VVFTSMFALEMILKLAAFGLF----DYLRNPYNIFDSIIVIISIWEIV----GQADGG-- 726
+F +F +E LK+ A+GL YLRN +N+ D IIV++ ++ + +ADG
Sbjct: 164 YLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANA 223
Query: 727 ---------LSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFS 777
+ LR FR+LR L+LV +P+L+ L ++K M + +L++ I I++
Sbjct: 224 LGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 283
Query: 778 ILGMHIFGCKF----------------------SLRTDTGDTVPDR-------------- 801
I+G+ +F K +L T G +
Sbjct: 284 IIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGI 343
Query: 802 KNFDSLLWAIVTVFQILTQEDWNVVLY---NGMASTSPWASLYFVALMTFGNYVLFNLLV 858
NFD+ +A++TVFQ +T E W VLY + + PW +YFV L+ G++ + NL++
Sbjct: 344 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPW--IYFVTLIIIGSFFVLNLVL 401
Query: 859 AILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQEGL 895
+L F E + ++ D + E +L+E L
Sbjct: 402 GVLSGEFSKEREKAKARGD----FQKLREKQQLEEDL 434
Score = 92.8 bits (229), Expect = 3e-18
Identities = 77/351 (21%), Positives = 150/351 (42%), Gaps = 44/351 (12%)
Query: 582 SAGGEDEADGDGARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKY 641
+ G EDE + + SEL +E+ + + + R + IV+
Sbjct: 842 TTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTI 901
Query: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTN-ILEICNVVFTSMFALEMILKLAAFGLF--- 697
F I+ IL++++S+ E Q N IL + VFTS+F LE+ILK+ A+G F
Sbjct: 902 FTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHK 961
Query: 698 -DYLRNPYNIFDSIIVIISI--WEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVV 754
+ RN +NI D ++V +S+ + I A + +LR R+LR L+ + L+ +
Sbjct: 962 GSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQC 1021
Query: 755 LMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVP--------------- 799
+ + + ++ L F+F+ +G+ +F K +D+
Sbjct: 1022 VFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEV 1081
Query: 800 ------------DRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSP----------W 837
+ +FD++L A++ +F + T E W +LY + S +
Sbjct: 1082 DHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVE 1141
Query: 838 ASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEF 888
S++F+ + + + N+ V ++ FQ +G+ + D++ E+
Sbjct: 1142 ISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEY 1192
Score = 88.6 bits (218), Expect = 6e-17
Identities = 71/243 (29%), Positives = 113/243 (46%), Gaps = 21/243 (8%)
Query: 3 ESASPPSSSAAAPAAEPGVTTEQP--------GPRSPPSSPPGLEEPLDGADPHVPHPDL 54
+ P + +P P T E+ GPR P S L+E VP P+
Sbjct: 824 DDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKA------VPMPEA 877
Query: 55 APIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKI 114
+ AFF R C ++V + F + + ILL+ ++L P S R I
Sbjct: 878 S--AFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHT---SFRNHI 932
Query: 115 LQVFDDFIFIFFAMEMVLKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN 173
L D F +E++LKM A G F K + + +N LD +V ++ + + IN
Sbjct: 933 LGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAIN 992
Query: 174 LSAI-RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWA 232
+ I R +RVLRPL+AINR ++ +V + + +GN++++ + F+F IGVQL+
Sbjct: 993 VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFK 1052
Query: 233 GLL 235
G L
Sbjct: 1053 GKL 1055
Score = 84.0 bits (206), Expect = 2e-15
Identities = 68/300 (22%), Positives = 136/300 (45%), Gaps = 58/300 (19%)
Query: 1490 DIFITFIICLNVVTMSLE---HYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGL--- 1543
+I I I N V +++ + + + L+ Y+F +F +EA LK++A+GL
Sbjct: 127 EIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFH 186
Query: 1544 -RRFFKDRWNQLDLAIVLLSVMGITLEEI-EINAALPINPT----IIRIMRVLRIARVLK 1597
+ ++ WN LD IV++ + LE+ + + A + ++ +R R+ R L+
Sbjct: 187 PNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR 246
Query: 1598 LLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GKL--VC-------- 1646
L+ ++ +L+++++A+ + ++ LL + + IYA +G+ELF GK+ C
Sbjct: 247 LVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAD 306
Query: 1647 ----NDENPCEGMSRH---------------------ATFENFGMAFLTLFQVSTGDNWN 1681
+D +PC + H F+NF A LT+FQ T + W
Sbjct: 307 VPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWT 366
Query: 1682 GIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQ 1741
++ + D + +YFV+ ++ F ++N+V+ VL ++A+
Sbjct: 367 DVLY-WVNDAVGRDWPW---------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Score = 68.9 bits (167), Expect = 5e-11
Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 16/171 (9%)
Query: 75 MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEMVLK 133
+V + +FE + ++ILLN + L M CL KI + +F F +EM+LK
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLF---KIAMNILNMLFTGLFTVEMILK 1269
Query: 134 MVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQN-------INLSAIRTVRVLRPL 186
++A F K Y D WN D IV+ +V+ ++ N I+++ R RV+R +
Sbjct: 1270 LIA---FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRLFRVMRLV 1326
Query: 187 KAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRN 237
K ++R +R L+ + + L V LL +FFI+ +IG+Q++ + N
Sbjct: 1327 KLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALN 1377
Score = 63.5 bits (153), Expect = 2e-09
Identities = 39/116 (33%), Positives = 64/116 (55%), Gaps = 7/116 (6%)
Query: 122 IFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLD----LQNINLSAI 177
+ F EM+LKM +LG+ + Y +NR D F+V G++E L + + +S +
Sbjct: 563 LLALFTAEMLLKMYSLGL---QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVL 619
Query: 178 RTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233
R VR+LR K S+ LV LL+++ + ++LLL F IF ++G+QL+ G
Sbjct: 620 RCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGG 675
Score = 57.4 bits (137), Expect = 2e-07
Identities = 31/91 (34%), Positives = 55/91 (60%), Gaps = 11/91 (12%)
Query: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHS-----FYNF-----IYFILLIIVGSFF 388
+FDN+ A + +F V T EGW E++Y +D+H+ YN+ I+FI+ II+ +FF
Sbjct: 1097 DFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFF 1156
Query: 389 MINLCLVVIATQFSETKQREHR-LMLEQRQR 418
M+N+ + + F E ++E++ L++ QR
Sbjct: 1157 MMNIFVGFVIVTFQEQGEQEYKNCELDKNQR 1187
Score = 44.3 bits (103), Expect = 0.001
Identities = 21/72 (29%), Positives = 40/72 (55%), Gaps = 6/72 (8%)
Query: 340 FDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNF------IYFILLIIVGSFFMINLC 393
FDN + + +FQ++T E W +MY + A+ +F IYFI+L I G++ ++N+
Sbjct: 689 FDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVF 748
Query: 394 LVVIATQFSETK 405
L + ++ +
Sbjct: 749 LAIAVDNLADAE 760
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,622,813
Number of Sequences: 37866
Number of extensions: 5387179
Number of successful extensions: 61060
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 889
Number of HSP's that attempted gapping in prelim test: 42211
Number of HSP's gapped (non-prelim): 14828
length of query: 2223
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2105
effective length of database: 13,779,330
effective search space: 29005489650
effective search space used: 29005489650
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.