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Search of human proteins with 21359873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21359873 polo-like kinase 1 [Homo sapiens]
(603 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21359873 polo-like kinase 1 [Homo sapiens] 1216 0.0
gi|41872374 polo-like kinase 3 [Homo sapiens] 456 e-128
gi|93004081 polo-like kinase 2 [Homo sapiens] 447 e-125
gi|121114283 polo-like kinase 4 [Homo sapiens] 205 1e-52
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 163 4e-40
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 163 5e-40
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 159 9e-39
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 157 2e-38
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 150 2e-36
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 150 2e-36
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 150 2e-36
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 150 2e-36
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 148 1e-35
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 148 1e-35
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 148 1e-35
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 148 1e-35
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 148 1e-35
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 148 1e-35
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 148 2e-35
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 147 2e-35
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 145 8e-35
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 145 8e-35
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 145 1e-34
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 145 1e-34
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 144 2e-34
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 1216 bits (3147), Expect = 0.0
Identities = 603/603 (100%), Positives = 603/603 (100%)
Query: 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG 60
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
Sbjct: 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG 60
Query: 61 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF 120
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
Sbjct: 61 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF 120
Query: 121 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG 180
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
Sbjct: 121 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG 180
Query: 181 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI 240
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
Sbjct: 181 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI 240
Query: 241 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL 300
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
Sbjct: 241 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL 300
Query: 301 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE 360
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
Sbjct: 301 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE 360
Query: 361 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK 420
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
Sbjct: 361 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK 420
Query: 421 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK 480
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
Sbjct: 421 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK 480
Query: 481 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK 540
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
Sbjct: 481 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK 540
Query: 541 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL 600
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
Sbjct: 541 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL 600
Query: 601 KAS 603
KAS
Sbjct: 601 KAS 603
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 456 bits (1172), Expect = e-128
Identities = 259/637 (40%), Positives = 359/637 (56%), Gaps = 57/637 (8%)
Query: 9 KLARAPADPGKAGVPGVAAPGAPA---AAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFA 65
+ A APA P G P A G A P + ++ DPRS R Y++GR LGKGGFA
Sbjct: 15 RAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFA 74
Query: 66 KCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDF 125
+C+E +D +T +A K++P+S + KPHQREK+ EI +HR L H+H+V F FED D
Sbjct: 75 RCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADN 134
Query: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
+++ LELC R+SL + K R L EPE RYYLRQI+ G +YLH+ ++HRDLKLGN F+
Sbjct: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT 194
Query: 186 EDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLL 245
E++E+K+GDFGLA ++E +RKKT+CGTPNY+APEVL ++GH E DVWS+GC+MYTLL
Sbjct: 195 ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLL 254
Query: 246 VGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF 305
G PPFET+ LKETY IK+ Y++P ++ A L+ +L+ P RP+I+++L +FF
Sbjct: 255 CGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF 314
Query: 306 TSGYIPARLPI-TCLTIPPRFSIAPS-SLDPSNRKPLTVLNKGLENPLPERPR------- 356
T GY P RLPI +C+T+P P+ SL K L K +N ER
Sbjct: 315 TKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSG 374
Query: 357 -----------EKEEPVVRETGEV--VDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDP 403
E P V V+ D + ++ E GL E
Sbjct: 375 LMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESA 434
Query: 404 ACI----------------------PIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTR 441
C P+ WVSKWVDYS+K+G GYQL V VLFND T
Sbjct: 435 LCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTH 494
Query: 442 LILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPRE 501
+ L + ++ Y +V + P +L ++ +L+YF +YM +HL+K G ++ E
Sbjct: 495 MALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMK-GGDLPSVE 553
Query: 502 GDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILC---PLMAAVTYIDEKRD 558
E+ P L W +T A+++ S+G+VQ+NF+ DHTKLIL PL+ VT++ R
Sbjct: 554 EVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLL--VTFVARNRS 611
Query: 559 FRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRS 595
TY S L + GC +L RLRYA +LL RS
Sbjct: 612 ACTYLASHLRQLGCSPDLRQRLRYAL----RLLRDRS 644
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 447 bits (1149), Expect = e-125
Identities = 248/650 (38%), Positives = 361/650 (55%), Gaps = 76/650 (11%)
Query: 12 RAPADPGKAGVPGVAAPGAPAAAP--------PAKEIPEVLVDPRSRRRYVRGRFLGKGG 63
+ P P + P + P AAP EI ++VDP + +RY RG+ LGKGG
Sbjct: 33 KRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGG 92
Query: 64 FAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDN 123
FAKC+E++D +V+A KI+P S + KPHQREK+ EI +HR L H+HVV F+ +FED
Sbjct: 93 FAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDK 152
Query: 124 DFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLF 183
+ ++++LE C RRS+ + K RK LTEPE RYYLRQIV G +YLH ++HRDLKLGN F
Sbjct: 153 ENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 212
Query: 184 LNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
+NE +E+K+GDFGLA ++E R++T+CGTPNY++PEVL+K+GH E D+W++GC+MYT
Sbjct: 213 INEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYT 272
Query: 244 LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDE 303
+L+G+PPFET+ LKETY I++ Y++P + A LI ML +P RP++++++ +
Sbjct: 273 MLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHD 332
Query: 304 FFTSGYIPARLPITCLTIPPRFSIAPSS---------------------LDPSNR----- 337
FF G+ P RL +C P F ++ + +D NR
Sbjct: 333 FFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKED 392
Query: 338 ----KPLTVLNKGLENPLPERPREKEE-------------PVVRETGEVVDCHLSDMLQQ 380
K L K P + R EE P V ++ D +
Sbjct: 393 EDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGT 452
Query: 381 LHSVNAS----KPSERGLVRQ----------EEAEDPACIP-------IFWVSKWVDYSD 419
L S ++S + S G V E + CIP WV+KWVDYS+
Sbjct: 453 LGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSN 512
Query: 420 KYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLL 479
KYG GYQL D++VGVLFN+ + L D ++ Y G S + P + ++T+L
Sbjct: 513 KYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVL 572
Query: 480 KYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHT 539
KYF +YM E+L+ G P D YL W ++ A+++ ++G+ Q+NF+ DHT
Sbjct: 573 KYFSHYMEENLMDGGD--LPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHT 630
Query: 540 KLILCPLMA--AVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMV 587
K+I+C +TYI+E R T+RL+ L GC EL +R+ YA M+
Sbjct: 631 KIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNML 680
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 205 bits (521), Expect = 1e-52
Identities = 95/252 (37%), Positives = 155/252 (61%), Gaps = 1/252 (0%)
Query: 56 GRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVG 115
G LGKG FA + T A K++ K + K +++ E+ IH L H ++
Sbjct: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
Query: 116 FHGFFEDNDFVFVVLELCRRRSLLELHKRR-KALTEPEARYYLRQIVLGCQYLHRNRVIH 174
+ +FED+++V++VLE+C + K R K +E EAR+++ QI+ G YLH + ++H
Sbjct: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
Query: 175 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDV 234
RDL L NL L ++ +KI DFGLAT+++ E+ TLCGTPNYI+PE+ ++ H E DV
Sbjct: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
Query: 235 WSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARP 294
WS+GC+ YTLL+G+PPF+T +K T ++ +Y +P ++ A LI ++L+ +P R
Sbjct: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
Query: 295 TINELLNDEFFT 306
+++ +L+ F +
Sbjct: 255 SLSSVLDHPFMS 266
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 163 bits (413), Expect = 4e-40
Identities = 92/286 (32%), Positives = 151/286 (52%), Gaps = 9/286 (3%)
Query: 28 PGAPAAAPPAKEIPEVLVDPRSRRR------YVRGRFLGKGGFAKCFEISDADTKEVFAG 81
P AP P +E+ + S++R + GR LGKG F + + +K + A
Sbjct: 103 PSAPENNPE-EELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILAL 161
Query: 82 KIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEL 141
K++ K+ L K ++ E+ I L H +++ +G+F D V+++LE ++
Sbjct: 162 KVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRE 221
Query: 142 HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV 201
++ E Y+ ++ Y H RVIHRD+K NL L E+KI DFG + V
Sbjct: 222 LQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS--V 279
Query: 202 EYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYL 261
R+ TLCGT +Y+ PE++ + H +VD+WS+G + Y LVGKPPFE + +ETY
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYK 339
Query: 262 RIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 307
RI + E++ P + A LI ++L+ +P+ RP + E+L + T+
Sbjct: 340 RISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITA 385
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 163 bits (412), Expect = 5e-40
Identities = 95/295 (32%), Positives = 159/295 (53%), Gaps = 15/295 (5%)
Query: 53 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQH 112
Y GR LGKG F E +D +T+ +A K V K + + E++I +S+ H+H
Sbjct: 116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVK-LLEREVNILKSVKHEH 174
Query: 113 VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 172
++ FE +++V+ELC L E+ R+ +E E R+ ++ + YLH N +
Sbjct: 175 IIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDI 234
Query: 173 IHRDLKLGNLFLNE---------DLEVKIGDFGLATKVEYDGERK-KTLCGTPNYIAPEV 222
+HRDLKL N+ + +L +K+ DFGLA K + E + CGTP Y+APEV
Sbjct: 235 VHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEV 294
Query: 223 LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEY----SIPKHINPVA 278
+S +S + D+WSIG +MY LL G+PPF S ++ + I+K E ++ I+ A
Sbjct: 295 ISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCA 354
Query: 279 ASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLD 333
S+++++++ DP R T ELL++++ T + + P L + + P S++
Sbjct: 355 KSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVE 409
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 159 bits (401), Expect = 9e-39
Identities = 131/423 (30%), Positives = 198/423 (46%), Gaps = 41/423 (9%)
Query: 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPE-VLVDPRSRRR------- 52
M AA G L PA PG G G PAAA +P V PR R R
Sbjct: 1 MPAAAGDGLLGE-PAAPGGGG--GAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKR 57
Query: 53 ----YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-HQREKMSMEISIHRS 107
+ R LG+G FAK E T E A K++ K K + + + E I +
Sbjct: 58 VGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQM 117
Query: 108 LAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYL 167
+ H ++ E + ++V+ELC +L+ +K L E EAR Y+RQ++ ++L
Sbjct: 118 IRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHL 177
Query: 168 HRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDG--ERKKTLCGTPNYIAPEVLSK 225
HR V+HRDLK+ NL L+ED +K+ DFGL+ G + T CG+P Y APE+L++
Sbjct: 178 HRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLAR 237
Query: 226 KGHSFEVDVWSIGCIMYTLLVGKPPF--ETSCLKETYLRIKKNEYS-IPKHINPVAASLI 282
K + ++DVWSIG MY +L G PF E L+ Y ++ E + +P ++ A S +
Sbjct: 238 KKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFL 297
Query: 283 QKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTV 342
+ +L+ DP RP I + L + + Y ++P +T P R S+ S P V
Sbjct: 298 RSLLEPDPVKRPNIQQALANRWLNENY-TGKVPCN-VTYPNRISLEDLS-------PSVV 348
Query: 343 LNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAED 402
L+ + E+ K V+ CH+ + L +K ER L + + +D
Sbjct: 349 LH------MTEKLGYKNSDVINTVLSNRACHILAIYFLL-----NKKLERYLSGKSDIQD 397
Query: 403 PAC 405
C
Sbjct: 398 SLC 400
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 157 bits (398), Expect = 2e-38
Identities = 101/311 (32%), Positives = 156/311 (50%), Gaps = 7/311 (2%)
Query: 2 SAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKE--IPEVLVDPRSRRRYVRGRFL 59
+AA AG R G G P A GA AA P K + + RY L
Sbjct: 4 AAAPVAGD--RPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETL 61
Query: 60 GKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGF 119
GKG + K ++ + V A K + K + + EI I SL H H++ +
Sbjct: 62 GKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEV 121
Query: 120 FEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKL 179
FE+ D + +++E + L + R+ L+E E R++ RQIV Y H+N V+HRDLKL
Sbjct: 122 FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKL 181
Query: 180 GNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGH-SFEVDVWSIG 238
N+ L+++ +KI DFGL+ + D + +T CG+P Y +PE+++ + + EVD W++G
Sbjct: 182 ENILLDDNCNIKIADFGLSNLYQKD-KFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG 240
Query: 239 CIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINE 298
++YTL+ G PF+ K +I EY P + A LI+ ML +P R TI +
Sbjct: 241 VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSD-ARGLIRWMLMVNPDRRATIED 299
Query: 299 LLNDEFFTSGY 309
+ N + GY
Sbjct: 300 IANHWWVNWGY 310
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 150 bits (380), Expect = 2e-36
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++++E + + + E EAR RQIV QY H+ R++HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L+++ L +P R T+
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLE 299
Query: 298 ELLNDEFFTSGY 309
+++ D + +G+
Sbjct: 300 QIMKDRWINAGH 311
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 150 bits (380), Expect = 2e-36
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++++E + + + E EAR RQIV QY H+ R++HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L+++ L +P R T+
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLE 299
Query: 298 ELLNDEFFTSGY 309
+++ D + +G+
Sbjct: 300 QIMKDRWINAGH 311
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 150 bits (380), Expect = 2e-36
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++++E + + + E EAR RQIV QY H+ R++HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L+++ L +P R T+
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLE 299
Query: 298 ELLNDEFFTSGY 309
+++ D + +G+
Sbjct: 300 QIMKDRWINAGH 311
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 150 bits (380), Expect = 2e-36
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 62 IGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++++E + + + E EAR RQIV QY H+ R++HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 181 AENLLLDADMNIKIADFGFSNEFTVGG-KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 239
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L+++ L +P R T+
Sbjct: 240 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLE 299
Query: 298 ELLNDEFFTSGY 309
+++ D + +G+
Sbjct: 300 QIMKDRWINAGH 311
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T + A KI+ K+ L +K+ E+ I + L H ++V
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K L +P+ R T+
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 296
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 297 QIMKDRWMNVGH 308
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T + A KI+ K+ L +K+ E+ I + L H ++V
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K L +P+ R T+
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 296
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 297 QIMKDRWMNVGH 308
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T + A KI+ K+ L +K+ E+ I + L H ++V
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K L +P+ R T+
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 296
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 297 QIMKDRWMNVGH 308
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T + A KI+ K+ L +K+ E+ I + L H ++V
Sbjct: 59 IGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 178 AENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 236
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K L +P+ R T+
Sbjct: 237 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 296
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 297 QIMKDRWMNVGH 308
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 136/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T + A KI+ K+ L +K+ E+ I + L H ++V
Sbjct: 26 IGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKLFE 84
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 85 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 144
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 145 AENLLLDADMNIKIADFGFSNEFTF-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 203
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K L +P+ R T+
Sbjct: 204 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLE 263
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 264 QIMKDRWMNVGH 275
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 148 bits (374), Expect = 1e-35
Identities = 86/252 (34%), Positives = 135/252 (53%), Gaps = 3/252 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 66 IGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKLFE 124
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
E +++V+E + + + E EAR RQIV QY H+ ++HRDLK
Sbjct: 125 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLK 184
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVWSI 237
NL L+ D+ +KI DFG + + G + T CG+P Y APE+ KK EVDVWS+
Sbjct: 185 AENLLLDGDMNIKIADFGFSNEFTV-GNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 243
Query: 238 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
G I+YTL+ G PF+ LKE R+ + +Y IP +++ +L++K+L +P R ++
Sbjct: 244 GVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLE 303
Query: 298 ELLNDEFFTSGY 309
+++ D + G+
Sbjct: 304 QIMKDRWMNVGH 315
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 148 bits (373), Expect = 2e-35
Identities = 84/254 (33%), Positives = 134/254 (52%), Gaps = 3/254 (1%)
Query: 57 RFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGF 116
R +GKG FAK T A KI+ K+ L P +K+ E+ I + L H ++V
Sbjct: 63 RTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPNIVKL 121
Query: 117 HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 176
E +++V+E + + + E EAR RQIV Y H+ ++HRD
Sbjct: 122 FEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 181
Query: 177 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVL-SKKGHSFEVDVW 235
LK NL L+ + +KI DFG + + G + T CG+P Y APE+ KK EVD+W
Sbjct: 182 LKAENLLLDAEANIKIADFGFSNEFTL-GSKLDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
Query: 236 SIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPT 295
S+G I+YTL+ G PF+ LKE R+ + +Y +P +++ S++++ L +P R T
Sbjct: 241 SLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCT 300
Query: 296 INELLNDEFFTSGY 309
+ +++ D++ GY
Sbjct: 301 LEQIMKDKWINIGY 314
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 147 bits (372), Expect = 2e-35
Identities = 89/261 (34%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
Query: 50 RRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA 109
R RY LGKG + K + ++ + V A K + K + + EI I SL
Sbjct: 50 RHRYEFLETLGKGTYGKVKKARESSGRLV-AIKSIRKDKIKDEQDLMHIRREIEIMSSLN 108
Query: 110 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 169
H H++ H FE++ + +V+E R L + R+ L+E EAR++ RQIV Y H+
Sbjct: 109 HPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQ 168
Query: 170 NRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHS 229
NRV+HRDLKL N+ L+ + +KI DFGL + + + G+ +T CG+P Y +PE+++ K ++
Sbjct: 169 NRVVHRDLKLENILLDANGNIKIADFGL-SNLYHQGKFLQTFCGSPLYASPEIVNGKPYT 227
Query: 230 F-EVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQT 288
EVD WS+G ++Y L+ G PF+ K +I Y P + A LI+ +L
Sbjct: 228 GPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSD-ACGLIRWLLMV 286
Query: 289 DPTARPTINELLNDEFFTSGY 309
+PT R T+ ++ + + GY
Sbjct: 287 NPTRRATLEDVASHWWVNWGY 307
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 145 bits (367), Expect = 8e-35
Identities = 83/260 (31%), Positives = 144/260 (55%), Gaps = 11/260 (4%)
Query: 57 RFLGKGGFAKCF---EISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHV 113
+ LG+G F K F +IS +D ++++A K++ K+ L K R + ME I + H +
Sbjct: 72 KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL-KVRDRVRTKMERDILVEVNHPFI 130
Query: 114 VGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 173
V H F+ ++++L+ R L + TE + ++YL ++ L +LH +I
Sbjct: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190
Query: 174 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKK-TLCGTPNYIAPEVLSKKGHSFEV 232
+RDLK N+ L+E+ +K+ DFGL+ K D E+K + CGT Y+APEV++++GH+
Sbjct: 191 YRDLKPENILLDEEGHIKLTDFGLS-KESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSA 249
Query: 233 DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA 292
D WS G +M+ +L G PF+ KET I K + +P+ ++P A SL++ + + +P
Sbjct: 250 DWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPAN 309
Query: 293 R-----PTINELLNDEFFTS 307
R + E+ FF++
Sbjct: 310 RLGAGPDGVEEIKRHSFFST 329
Score = 118 bits (295), Expect = 2e-26
Identities = 77/248 (31%), Positives = 123/248 (49%), Gaps = 17/248 (6%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
+G G ++ C T FA KI+ KS K E++ + + R H +++
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS---KRDPTEEIEILL---RYGQHPNIITLKD 481
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
++D +V+VV EL + LL+ R+K +E EA L I +YLH V+HRDLK
Sbjct: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
Query: 179 LGNLFLNEDL----EVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDV 234
N+ ++ ++I DFG A ++ + T C T N++APEVL ++G+ D+
Sbjct: 542 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 601
Query: 235 WSIGCIMYTLLVGKPPFET---SCLKETYLRIKKNEYSIP----KHINPVAASLIQKMLQ 287
WS+G ++YT+L G PF +E RI ++S+ ++ A L+ KML
Sbjct: 602 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 661
Query: 288 TDPTARPT 295
DP R T
Sbjct: 662 VDPHQRLT 669
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 145 bits (367), Expect = 8e-35
Identities = 87/254 (34%), Positives = 132/254 (51%), Gaps = 2/254 (0%)
Query: 53 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQH 112
Y+ G LG G F K T A KI+ + + K+ EI + H H
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 113 VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 172
++ + +F+V+E L + + L E E+R +QI+ G Y HR+ V
Sbjct: 87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMV 146
Query: 173 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSF-E 231
+HRDLK N+ L+ + KI DFGL+ + DGE +T CG+PNY APEV+S + ++ E
Sbjct: 147 VHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPE 205
Query: 232 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT 291
VD+WS G I+Y LL G PF+ + + +I + P+++NP SL++ MLQ DP
Sbjct: 206 VDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPM 265
Query: 292 ARPTINELLNDEFF 305
R TI ++ E+F
Sbjct: 266 KRATIKDIREHEWF 279
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 145 bits (366), Expect = 1e-34
Identities = 90/296 (30%), Positives = 147/296 (49%), Gaps = 12/296 (4%)
Query: 8 GKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRR--YVRGRFLGKGGFA 65
G + PA G A P A A PP + PR +R + G+ LG+G F+
Sbjct: 43 GGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQ--------PRKKRPEDFKFGKILGEGSFS 94
Query: 66 KCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDF 125
+ T +A KI+ K ++K ++ ++ E + L H V + F+D++
Sbjct: 95 TVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEK 154
Query: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
++ L + LL+ ++ + E R+Y +IV +YLH +IHRDLK N+ LN
Sbjct: 155 LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN 214
Query: 186 EDLEVKIGDFGLATKVEYDGE--RKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
ED+ ++I DFG A + + + R + GT Y++PE+L++K D+W++GCI+Y
Sbjct: 215 EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQ 274
Query: 244 LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINEL 299
L+ G PPF + +I K EY P+ P A L++K+L D T R E+
Sbjct: 275 LVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM 330
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 145 bits (366), Expect = 1e-34
Identities = 90/296 (30%), Positives = 147/296 (49%), Gaps = 12/296 (4%)
Query: 8 GKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRR--YVRGRFLGKGGFA 65
G + PA G A P A A PP + PR +R + G+ LG+G F+
Sbjct: 16 GGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQ--------PRKKRPEDFKFGKILGEGSFS 67
Query: 66 KCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDF 125
+ T +A KI+ K ++K ++ ++ E + L H V + F+D++
Sbjct: 68 TVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEK 127
Query: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
++ L + LL+ ++ + E R+Y +IV +YLH +IHRDLK N+ LN
Sbjct: 128 LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN 187
Query: 186 EDLEVKIGDFGLATKVEYDGE--RKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
ED+ ++I DFG A + + + R + GT Y++PE+L++K D+W++GCI+Y
Sbjct: 188 EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQ 247
Query: 244 LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINEL 299
L+ G PPF + +I K EY P+ P A L++K+L D T R E+
Sbjct: 248 LVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEM 303
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 144 bits (364), Expect = 2e-34
Identities = 82/237 (34%), Positives = 126/237 (53%), Gaps = 3/237 (1%)
Query: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 118
LG GGF + + + FA K + K ++ Q+E + E I L +V +
Sbjct: 459 LGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYR 518
Query: 119 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
F+DN +V+++LE C L + + R + EP +++ + + YLHR +I+RDLK
Sbjct: 519 TFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLK 578
Query: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG 238
NL L+ + +K+ DFG A K+ G++ T CGTP Y+APEV+ KGH F VD WS+G
Sbjct: 579 PENLILDAEGYLKLVDFGFAKKIG-SGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLG 637
Query: 239 CIMYTLLVGKPPFETSCLKETYLRIKK--NEYSIPKHINPVAASLIQKMLQTDPTAR 293
++Y LL G PPF TY I K + P+ I LI+++ + +PT R
Sbjct: 638 ILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTER 694
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,275,904
Number of Sequences: 37866
Number of extensions: 1193252
Number of successful extensions: 7637
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 732
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 5537
Number of HSP's gapped (non-prelim): 1108
length of query: 603
length of database: 18,247,518
effective HSP length: 108
effective length of query: 495
effective length of database: 14,157,990
effective search space: 7008205050
effective search space used: 7008205050
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.