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Search of human proteins with 21359846
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21359846 prospero homeobox 1 [Homo sapiens]
(737 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21359846 prospero homeobox 1 [Homo sapiens] 1479 0.0
gi|122937215 prospero homeobox 2 [Homo sapiens] 307 2e-83
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 52 2e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 47 5e-05
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 47 8e-05
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 47 8e-05
gi|148746195 trichohyalin [Homo sapiens] 47 8e-05
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 47 8e-05
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 47 8e-05
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 47 8e-05
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 47 8e-05
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 47 8e-05
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 47 8e-05
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 47 8e-05
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 47 8e-05
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 46 1e-04
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 46 1e-04
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 46 1e-04
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 45 2e-04
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 45 2e-04
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 45 2e-04
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 45 2e-04
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 45 3e-04
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 45 3e-04
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 44 4e-04
gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo... 44 5e-04
gi|221219020 NYD-SP11 protein [Homo sapiens] 44 7e-04
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 43 0.001
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 43 0.001
gi|239752551 PREDICTED: hypothetical protein [Homo sapiens] 42 0.002
>gi|21359846 prospero homeobox 1 [Homo sapiens]
Length = 737
Score = 1479 bits (3830), Expect = 0.0
Identities = 737/737 (100%), Positives = 737/737 (100%)
Query: 1 MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQ 60
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQ
Sbjct: 1 MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQ 60
Query: 61 HADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTG 120
HADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTG
Sbjct: 61 HADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTG 120
Query: 121 SEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSP 180
SEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSP
Sbjct: 121 SEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSP 180
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK
Sbjct: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
Query: 241 QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC 300
QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC
Sbjct: 241 QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC 300
Query: 301 ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAM 360
ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAM
Sbjct: 301 ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAM 360
Query: 361 SQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNP 420
SQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNP
Sbjct: 361 SQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNP 420
Query: 421 LDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTF 480
LDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTF
Sbjct: 421 LDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTF 480
Query: 481 RHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSP 540
RHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSP
Sbjct: 481 RHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSP 540
Query: 541 AHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSS 600
AHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSS
Sbjct: 541 AHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSS 600
Query: 601 NMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCE 660
NMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCE
Sbjct: 601 NMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCE 660
Query: 661 LYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSE 720
LYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSE
Sbjct: 661 LYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSE 720
Query: 721 VPEIFKSPNCLQELLHE 737
VPEIFKSPNCLQELLHE
Sbjct: 721 VPEIFKSPNCLQELLHE 737
>gi|122937215 prospero homeobox 2 [Homo sapiens]
Length = 592
Score = 307 bits (787), Expect = 2e-83
Identities = 228/623 (36%), Positives = 310/623 (49%), Gaps = 71/623 (11%)
Query: 124 HQEDICSNSSRDSPPECL---SPFGR---PTMSQFDMDRLCDEHLRAKRARVENIIRGMS 177
H + C+ R S P L SPF P+ S D + DEH++AKRARVE I+RGM
Sbjct: 17 HLAEACTEGERSSSPPELDRDSPFPWSQVPSSSPTDPEWFGDEHIQAKRARVETIVRGMC 76
Query: 178 HSPSVALRGNENEREMAPQSVSPR--ESYRENKRKQKLPQQQQQSFQQLVSARKEQKREE 235
SP+ + GN A VSPR + RE KRKQ LP Q A + R+
Sbjct: 77 LSPNPLVPGN------AQAGVSPRCPKKARERKRKQNLPTPQ--GLLMPAPAWDQGNRKG 128
Query: 236 RRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS 295
++++QL +++QLR LQE Q D+ G + L A+ + G
Sbjct: 129 GPRVREQLHLLKQQLRHLQEHILQAAKPRDTAQGPGGCGTGKGP----LSAKQGNGCG-- 182
Query: 296 DNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQE 355
R + + + +K + P+ L E L++E
Sbjct: 183 -------------PRPWVVDGDHQQGTSKDLSGAEKHQESEKPSFLPSGAPASLEILRKE 229
Query: 356 LNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQ--IPQARFA----VNGENHN---FHTAN 406
L A+SQ VD+V++ P + Q+ Q + + R V G +
Sbjct: 230 LTRAVSQAVDSVLQKVLLDPPGHLTQLGRSFQGQVAEGRSEPSPPVGGACKDPLALAALP 289
Query: 407 QRLQCFGDVIIPNPLDTFGNVQMASSTDQTE--ALPLVVRKNSSDQSASGPAAGGHHQPL 464
+R+Q V + GN+ +A D P + K D A+ P H
Sbjct: 290 RRVQLQAGVPV-------GNLSLAKRLDSPRYPIPPRMTPKPCQDPPANFPLTAPSHIQE 342
Query: 465 HQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSL 524
+Q LS G + P + + P P+ P+ L L++ L
Sbjct: 343 NQI-LSQLLGHRYNNGHWSSSPPQDSSSQRHPSSEPA--LRPWRTTKPQPLVLSQQQCPL 399
Query: 525 RTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNH 584
+S HL P P+ +K E L + E P+S +QEGL+P H
Sbjct: 400 --PFTSAHLESLPLLPS-------------VKMEQRGLHAVMEALPFSLLHIQEGLNPGH 444
Query: 585 LKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIN 644
LKKAKLMFF+TRYPSSN+LK YF DV+FNRCITSQ+IKWFSNFREFYYIQMEK ARQAI+
Sbjct: 445 LKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAIS 504
Query: 645 DGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDP 704
DGVT+ + L + R+ EL++ALNMHYNK NDFEVP+ FLE+A +TL+EFF A+ AG+D DP
Sbjct: 505 DGVTNPKMLVVLRNSELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDP 564
Query: 705 SWKKAIYKVICKLDSEVPEIFKS 727
SWKK IYK+I KLDS++PEIFKS
Sbjct: 565 SWKKPIYKIISKLDSDIPEIFKS 587
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 52.0 bits (123), Expect = 2e-06
Identities = 34/166 (20%), Positives = 76/166 (45%), Gaps = 8/166 (4%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E E +M Q + + ++++++ +Q++Q +Q +EQ RE+ Q+++Q E M
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ-----EEQMREQEEQMREQEEQMG 327
Query: 248 KQLRQLQEKFYQIYDSTDS--ENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPG 305
KQ Q+ E+ Q+++ + + +E E+ M+ + R Q+ R E
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEE 387
Query: 306 QFIDRARALIREQE-MAENKPKREGNNKERDHGPNSLQPEGKHLAE 350
Q + + ++E M E K + ++ ++ + +H+ E
Sbjct: 388 QMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/148 (22%), Positives = 72/148 (48%), Gaps = 6/148 (4%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E E +M Q E + +++++ Q+Q++ ++ ++EQ RE+ Q+++Q E M
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK----QEEQMREQEEQMREQEEQML 279
Query: 248 KQLRQL-QEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ-DSVGRSDNEMCELDPG 305
KQ Q QE+ + E +E E+ MR + R Q + +G+ + +M E
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 306 QFIDRARALIREQEMAENKPKREGNNKE 333
+ + + +E++M E + + + ++
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/146 (19%), Positives = 66/146 (45%), Gaps = 3/146 (2%)
Query: 191 REMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQL 250
RE Q E + + ++Q Q ++ + ++EQ R++ Q+ +Q E +QKQ
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 251 RQLQEKFYQIYDSTDS--ENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFI 308
Q+Q++ Q+ + E +E E+ M + ++ G + +M E + Q
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEE-QMR 306
Query: 309 DRARALIREQEMAENKPKREGNNKER 334
++ + ++E + ++ G +E+
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQ 332
Score = 43.9 bits (102), Expect = 5e-04
Identities = 30/153 (19%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREER-RQLKQQLEDM 246
E E +M Q E + +++++ +Q++ Q+ + QK+EE+ R+ ++Q+ +
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK--QEEQVQKQEEQMRKQEEQMREQ 267
Query: 247 QKQLRQLQEKFYQIYDSTD-----SENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCE 301
++Q+R+ +E+ + + T+ E +E E+ MR + R Q+ R E
Sbjct: 268 EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMG 327
Query: 302 LDPGQFIDRARALIREQEMAENKPKREGNNKER 334
Q ++ + ++E + ++ G +E+
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ 360
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/137 (20%), Positives = 62/137 (45%), Gaps = 2/137 (1%)
Query: 148 TMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYREN 207
T Q + R +E +R + ++ M + E E Q +E +
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350
Query: 208 KRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSE 267
+ + ++Q Q ++ V ++EQ R++ Q+++Q E M+KQ Q+ E+ Q+ + +
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Query: 268 NDEDGNLSE--DSMRSE 282
+++ + E + MR +
Sbjct: 411 REQEEQMGEQKEQMRKQ 427
Score = 38.5 bits (88), Expect = 0.023
Identities = 33/169 (19%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E E ++ Q RE +E + +++ Q ++Q Q + ++ Q E+ Q+ +Q E MQ
Sbjct: 161 EQEGQVREQEGQVRE--QEGQVREQEGQVREQEGQ--MGEQEGQMGEQEEQMGEQEEQMQ 216
Query: 248 KQLRQLQEKFYQIYDSTDS--ENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPG 305
KQ Q+ E+ Q+ + E +E E+ ++ + R Q+ R E
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEE 276
Query: 306 QFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQ 354
Q + + +E++ E + + ++ ++ + + + E +Q
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Score = 37.0 bits (84), Expect = 0.066
Identities = 18/69 (26%), Positives = 35/69 (50%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E R+ Q E R+ + + + ++Q ++ + +KEQ RE+ Q+ +Q E M+
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 248 KQLRQLQEK 256
KQ + E+
Sbjct: 426 KQEEHMGEQ 434
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/89 (21%), Positives = 46/89 (51%), Gaps = 8/89 (8%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E E +M Q R K+++++ +Q++Q +Q RK++ E+ + K+Q+ + +
Sbjct: 356 EQEEQMQKQEEQVR------KQEEQMRKQEEQMRKQEEQMRKQE--EQMGEQKEQMGEQK 407
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSE 276
+Q+R+ +E+ + + + + G E
Sbjct: 408 EQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 47.4 bits (111), Expect = 5e-05
Identities = 40/175 (22%), Positives = 86/175 (49%), Gaps = 16/175 (9%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQL 243
LR + E+E R+ E R+QK+ + +++ ++ V ++E++ + Q ++++
Sbjct: 526 LRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEE-VKLKREERLRKVLQARERV 584
Query: 244 EDMQKQLR-QLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCEL 302
E M+++ + Q+++KF QI + T+ +E L+E+ + + + ++ R E
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQE---- 638
Query: 303 DPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ--PEGKHLAETLKQE 355
+ AR L Q+ E + +E K+++ L+ E K LAE +QE
Sbjct: 639 ------EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 687
Score = 43.9 bits (102), Expect = 5e-04
Identities = 35/148 (23%), Positives = 78/148 (52%), Gaps = 12/148 (8%)
Query: 149 MSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENK 208
+ Q + +R E L+ K+ + +R + + +A + + RE + RE +
Sbjct: 647 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE---------QERREQE 697
Query: 209 RKQKLPQQQQQSFQQLVSARKEQKRE-ERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSE 267
R+++ ++Q++ Q+ A +E++RE ER Q +++L++ +K LR LQ++ Q +
Sbjct: 698 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALR-LQKEQLQRELEEKKK 756
Query: 268 NDEDGNLSEDSMRSEILDARAQDSVGRS 295
+E L+E ++ E + +A+++ G S
Sbjct: 757 KEEQQRLAERQLQEE-QEKKAKEAAGAS 783
Score = 35.4 bits (80), Expect = 0.19
Identities = 33/179 (18%), Positives = 82/179 (45%), Gaps = 13/179 (7%)
Query: 159 DEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ 218
+E L ++A+ + + M A R E E E R + QK +++Q
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVE--ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 668
Query: 219 QSFQQLVSARK--EQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSE 276
+ ++ A++ EQ+ +ERR+ +++ ++ ++Q R+ QE+ Q + E + +
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE----Q 724
Query: 277 DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
+ +++E + + ++ R E + + ++ + +Q +AE + + E K ++
Sbjct: 725 ERLQAE-RELQEREKALRLQKEQLQRE----LEEKKKKEEQQRLAERQLQEEQEKKAKE 778
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 46.6 bits (109), Expect = 8e-05
Identities = 36/194 (18%), Positives = 91/194 (46%), Gaps = 16/194 (8%)
Query: 159 DEHLRAK--RARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
DE LR K R R + + + E E++ Q RE R +R++K+ ++
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSE 276
++ +Q +E+ +E+ ++++Q E M +Q ++QE+ ++++ + +++ E
Sbjct: 573 EEMMREQ-----EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE---EE 624
Query: 277 DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDH 336
D M+ + ++ + + +M E + + + +E++M E + K +G ++
Sbjct: 625 DKMQEQ------EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Query: 337 GPNSLQPEGKHLAE 350
+Q + + + E
Sbjct: 679 QEEKMQGQEEKMRE 692
Score = 44.7 bits (104), Expect = 3e-04
Identities = 39/190 (20%), Positives = 85/190 (44%), Gaps = 24/190 (12%)
Query: 157 LCDEHLRAKRARVENIIR-GMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+ +E L+ K A ++ +R S + L E +R++ + K LPQ
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKL-------------ERAKFLLPQ 226
Query: 216 QQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNL- 274
Q + Q+ + ++E+ RE+ +++++Q E M +Q +L+E+ ++ + + ++ L
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR 286
Query: 275 -SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEM--------AENKP 325
E +R + + R Q + + +M E + + + +E++M + K
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 326 KREGNNKERD 335
RE K RD
Sbjct: 347 MREQEQKMRD 356
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/178 (18%), Positives = 75/178 (42%), Gaps = 16/178 (8%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------- 230
R E E+E+ Q RE + ++++++ +Q+++ ++Q R++
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 343
Query: 231 --QKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARA 288
Q RE+ ++++ Q E M +Q +L+EK ++ + E+ E+ +R R
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 289 QDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGK 346
++ R E + ++ ++Q + E K K K ++ + E K
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Score = 36.6 bits (83), Expect = 0.086
Identities = 31/147 (21%), Positives = 71/147 (48%), Gaps = 22/147 (14%)
Query: 188 ENEREMAPQSVSPRESYREN-KRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDM 246
E E +M Q RE + ++++K+ +Q+++ ++Q K ++EE ++++Q E M
Sbjct: 578 EQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ---EEKMWEQEEEDKMQEQEEMM 634
Query: 247 QKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQ 306
+Q ++QE+ ++++ + ++ E+ MR + + Q+ R E + GQ
Sbjct: 635 WEQEEKMQEQEEKMWEQEEKMREQ-----EEKMREQEEKMQGQEEKMREQEEKMQ---GQ 686
Query: 307 FIDRARALIREQEMAENKPKREGNNKE 333
E++M E + K G ++
Sbjct: 687 ----------EEKMREQEEKMRGQEEK 703
Score = 35.8 bits (81), Expect = 0.15
Identities = 34/175 (19%), Positives = 83/175 (47%), Gaps = 18/175 (10%)
Query: 190 EREMAPQSVSPRESYREN-KRKQKLPQQQQQSFQQLVSARKEQKR--EERRQLKQQLEDM 246
E E+ Q R+ + +++++L +Q+ + +Q R+++KR E+ ++L++Q +++
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 247 --QKQLRQ----LQEKFYQIYDSTDSENDEDGNL---------SEDSMRSEILDARAQDS 291
QK+LR+ +QE+ ++++ + +++ + E MR + R Q+
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 292 VGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGK 346
+E + ++ + +E++M E + RE K R+ + E K
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/150 (20%), Positives = 66/150 (44%), Gaps = 10/150 (6%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKL-PQQQQQSFQQLVSARKEQKREERRQLKQQLEDM 246
+ E M Q RE + ++K+ Q+++ ++ + R+++ REE +++Q E M
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKM 415
Query: 247 QKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQ 306
QKQ + E+ + + ++ ++ M+ + Q+ R EM
Sbjct: 416 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW------ 469
Query: 307 FIDRARALIREQEMAENKPKR-EGNNKERD 335
+ + + R+++M E + + E K RD
Sbjct: 470 --GQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Score = 35.0 bits (79), Expect = 0.25
Identities = 32/141 (22%), Positives = 69/141 (48%), Gaps = 11/141 (7%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSAR-KEQKREERRQLKQQLEDM 246
E RE Q E R+ ++QK+ Q+++ ++Q R KE++ E++++ QQ E M
Sbjct: 479 EKMREQEDQMWEQEEKMRD--QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM 536
Query: 247 QKQLRQLQEKFYQIYDSTDSENDEDGNLS-EDSMRSEILDARAQDSVGRSDNEMCELDPG 305
+++ ++ QE+ + +D + +E+ E MR E ++ + + +M E +
Sbjct: 537 REE-KKTQEQEKKTWDQEEKMREEERMREREKKMREE------EEMMREQEEKMQEQEEK 589
Query: 306 QFIDRARALIREQEMAENKPK 326
+ +E++M E + K
Sbjct: 590 MREQEEKMWEQEEKMQEQEEK 610
Score = 33.9 bits (76), Expect = 0.56
Identities = 25/155 (16%), Positives = 73/155 (47%), Gaps = 10/155 (6%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E + ++ Q + + ++++K+ Q++ Q+ R+E+ RE+ Q+ +Q E M+
Sbjct: 437 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 496
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNL--------SEDSMRSEILDARAQDSVGRSDNEM 299
Q +++ ++ ++++ + +++ + E+ MR E + + +M
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 300 CELDPGQFIDRARALIREQEMAENKPKREGNNKER 334
E + + +R + + E+EM + ++ +E+
Sbjct: 557 REEE--RMREREKKMREEEEMMREQEEKMQEQEEK 589
Score = 31.2 bits (69), Expect = 3.6
Identities = 38/186 (20%), Positives = 83/186 (44%), Gaps = 25/186 (13%)
Query: 188 ENEREMAPQSVSPRESYREN---KRKQKLPQQQQQSFQQLVSARKEQKREER-RQLKQQL 243
E E +M Q + +E ++++K+ +Q+++ ++Q K +++EE+ R+ ++++
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ---EEKMREQEEKMREQEEKM 669
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELD 303
+ ++++R+ +EK Q + E +E E+ M + Q+ EM E +
Sbjct: 670 QGQEEKMREQEEKM-QGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKE 728
Query: 304 PGQFIDRARALIREQEMAENKPKREGNNKERDHGPN----------SLQPEGKHLAETLK 353
R ++++M E P+ E E P+ S++P G E
Sbjct: 729 -------ERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEAGEGSP 781
Query: 354 QELNTA 359
Q+ TA
Sbjct: 782 QDNPTA 787
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 46.6 bits (109), Expect = 8e-05
Identities = 26/88 (29%), Positives = 56/88 (63%), Gaps = 4/88 (4%)
Query: 176 MSHS--PSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQ-- 231
MSHS P ++ + + +++ Q ++ + +++Q+L QQQQ QQL +++Q
Sbjct: 3881 MSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQL 3940
Query: 232 KREERRQLKQQLEDMQKQLRQLQEKFYQ 259
++++++QL+QQ + +Q+Q +Q Q++F Q
Sbjct: 3941 QQQQQQQLQQQQQQLQQQQQQQQQQFQQ 3968
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/134 (23%), Positives = 66/134 (49%), Gaps = 8/134 (5%)
Query: 175 GMSHSPSVALRGNENEREMAPQ---SVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQ 231
G+SH +L + + +++ Q S+ + ++ +++Q+L QQQQQ QQ +++Q
Sbjct: 3872 GLSHLQQ-SLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQ 3930
Query: 232 KREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDS 291
+++++Q QQL+ Q+Q QLQ++ Q+ + + + + +R S
Sbjct: 3931 LQQQQQQ--QQLQQQQQQ--QLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLS 3986
Query: 292 VGRSDNEMCELDPG 305
+ + L PG
Sbjct: 3987 PQQQQQQQVALGPG 4000
Score = 41.2 bits (95), Expect = 0.003
Identities = 27/117 (23%), Positives = 55/117 (47%), Gaps = 4/117 (3%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQ 249
++ + S P+ S + Q+L QQQQ QQ + +++Q+ ++++QL+QQ Q+Q
Sbjct: 3877 QQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQ 3936
Query: 250 LRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQ 306
+QLQ++ Q + + + + + + Q +G + L P Q
Sbjct: 3937 QQQLQQQQQQQLQQQQQQLQQ----QQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQ 3989
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 46.6 bits (109), Expect = 8e-05
Identities = 37/164 (22%), Positives = 77/164 (46%), Gaps = 10/164 (6%)
Query: 196 QSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQE 255
Q RE E + +Q+ +QQ++ +Q + +E++RE++ + +Q+ E ++QLR+ QE
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369
Query: 256 KFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALI 315
+ + + + + L + R + + R +L Q + R + L
Sbjct: 370 E-----ERREQQLRREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQQLR 420
Query: 316 REQEM-AENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNT 358
REQ++ E + +R E++ L+ E + + LK+E T
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/202 (19%), Positives = 89/202 (44%), Gaps = 11/202 (5%)
Query: 155 DRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLP 214
DR+ E + + E ++R + + +RE+ + R+ R+ R+++
Sbjct: 235 DRVFQEEEEKEWRKRETVLR--KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292
Query: 215 QQQQQS----FQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSE--- 267
++QQQ QQL ++E++RE++ + ++Q E ++Q + +++ + + +
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 268 NDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCE--LDPGQFIDRARALIREQEMAENKP 325
+++ E +R E + R + + R E L Q + R + L REQ++ +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 326 KREGNNKERDHGPNSLQPEGKH 347
R R+ Q E +H
Sbjct: 413 LRREQQLRREQQLRREQEEERH 434
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/173 (21%), Positives = 78/173 (45%), Gaps = 13/173 (7%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
+ E E + + +E +R+ + ++ QQ +QL+ +E++R+ER + ++ E++Q
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQF 307
+Q R+ Q Y D +D E + + D + GR + + +L+ Q
Sbjct: 1207 RQKRK------QRYRDEDQRSDLKWQW-EPEKENAVRDNKVY-CKGRENEQFRQLEDSQL 1258
Query: 308 IDR-----ARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQE 355
DR + L+ EQ+ + + +R + H P Q E + E +++
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/223 (20%), Positives = 89/223 (39%), Gaps = 19/223 (8%)
Query: 149 MSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENK 208
+ Q D R +E R ++ E R + +G+E E + + RE +
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220
Query: 209 RKQKLPQQQQQSFQQLVSARKEQK----------------REERRQLKQQLEDMQKQLRQ 252
+ ++ QQQ++ Q V +E+K +EE Q +++L++ ++QLR+
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 253 LQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRAR 312
L+ + + + + + + R + + R Q R E E + R +
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER---REQ 337
Query: 313 ALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQE 355
L REQE + R +ER + E + + L++E
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Score = 41.6 bits (96), Expect = 0.003
Identities = 46/204 (22%), Positives = 89/204 (43%), Gaps = 19/204 (9%)
Query: 159 DEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ 218
DE RA+ E++++ R +R++ + R R+ + ++ ++Q
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQR-RFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 219 QSFQQLVSARKEQKREE----RRQLKQQLEDMQKQLRQLQE-KFYQIYDSTDSENDEDGN 273
Q+ + R Q+R+E +RQ Q+ E+ + + QLQ K ++ + D E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 274 LSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQE-MAENKPKREGNNK 332
L E +R + + + Q R D E + ++ R L +E+E + E +P+R+
Sbjct: 215 LLE--LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ---- 268
Query: 333 ERDHGPNSLQPEGKHLAETLKQEL 356
LQ E + L + +QEL
Sbjct: 269 ------RELQEEEEQLRKLERQEL 286
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/171 (22%), Positives = 83/171 (48%), Gaps = 11/171 (6%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E + E Q +S R RE + +Q +++QQ Q+ + +E+K + RRQ +++ +++Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP-EEEEKEQRRRQRREREKELQ 832
Query: 248 ----KQLRQLQEKFYQIYDSTDS-ENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCEL 302
++ Q +E+ Q+ + D + D++ S++ R + + ++ R + +
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 303 DPGQ-FIDRARALIREQE---MAENKPKREGNNKERDH-GPNSLQPEGKHL 348
Q + + + L++E+E E + KR +ER + LQ E + L
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/158 (21%), Positives = 73/158 (46%), Gaps = 15/158 (9%)
Query: 184 LRGNENEREMAPQ---SVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
LR E +R+ Q S P + E +++ Q+Q++ Q+ R++++ ++RRQ +
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 241 QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC 300
+ ++QLRQ +E+ + E D L E +R + Q+ D +
Sbjct: 1554 DRKFREEEQLRQEREE----QQLSRQERDRKFRLEEQKVRRQ-----EQERKFMEDEQQL 1604
Query: 301 ELDPGQ---FIDRARALIREQEMAENKPKREGNNKERD 335
GQ +R R ++++ + + +++ + +ERD
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Score = 40.0 bits (92), Expect = 0.008
Identities = 34/147 (23%), Positives = 69/147 (46%), Gaps = 2/147 (1%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQ-QQQQSFQQLVSARKEQKREERRQLKQQ 242
L+ + ER + E + + +RKQ+L + Q+++ ++ + +E++RE++ + +QQ
Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 243 LEDMQKQLRQLQEKFYQIYDSTDSENDEDGNL-SEDSMRSEILDARAQDSVGRSDNEMCE 301
L Q++ R+ + K + + + L E R E L R ++ +
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 302 LDPGQFIDRARALIREQEMAENKPKRE 328
L Q R + L RE+E + + KRE
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKRE 593
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/164 (21%), Positives = 79/164 (48%), Gaps = 20/164 (12%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREER----------R 237
E E E+ + R + ++ ++ Q QQ+ Q L R++++R+ER +
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 238 QLKQQL--EDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILD----ARAQDS 291
Q ++QL E+ +K+ RQ +EK Y+ + + + +E+ L E+ + + R +D
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYR--EEEELQQEEEQLLREEREKRRRQEWERQYRKKDE 1025
Query: 292 VGRSDNEMC--ELDPGQFIDRARALIREQEMAENKPKREGNNKE 333
+ + + ++ E + + +R R E+E+ + + + G +E
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Score = 38.9 bits (89), Expect = 0.017
Identities = 32/155 (20%), Positives = 79/155 (50%), Gaps = 15/155 (9%)
Query: 195 PQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQL---- 250
P+ +E ++ + +++L Q+++Q ++ R+ Q+ E + + K +L+ ++QL
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 251 ---RQLQEKFYQIYDSTDSENDEDGNLSE--DSMRSEILDA--RAQDSVGRSDNEMCELD 303
R+LQE+ Q + + + +E+ L E ++ R + L+ R ++ + + + ++ +
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 304 P--GQFIDRARALIREQEMAENKPK--REGNNKER 334
P + +R R E+E+ + + + RE K R
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Score = 38.1 bits (87), Expect = 0.030
Identities = 36/179 (20%), Positives = 81/179 (45%), Gaps = 8/179 (4%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQL 243
LR +R + + RE + +++L +++++ ++ R+ +K EE +Q ++QL
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSE--DSMRSEILDA--RAQDSVGRSDNEM 299
+ + R+ QE+ Q + + + +E+ L E + R + L+ R ++ V + + ++
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 300 CELDP----GQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQ 354
+P Q ++R E + E + RE K R + E + + KQ
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Score = 38.1 bits (87), Expect = 0.030
Identities = 38/154 (24%), Positives = 68/154 (44%), Gaps = 7/154 (4%)
Query: 201 RESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQI 260
R R+ K +++ +Q++ QQL S ++K E QL+Q+ E+ Q + +Q K+
Sbjct: 1765 RRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWE 1824
Query: 261 YDSTDSENDEDGNLSEDSMRSEILDARA-QDSVGRSDNEMC-ELDPGQFIDRARAL---- 314
+ E E E + + A Q+ R + E+ E + + +R R L
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEH 1884
Query: 315 IREQEMAENKPKREGNNKERD-HGPNSLQPEGKH 347
IR Q+ E + ++ G K ++ G L G H
Sbjct: 1885 IRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTH 1918
Score = 37.7 bits (86), Expect = 0.039
Identities = 37/182 (20%), Positives = 78/182 (42%), Gaps = 14/182 (7%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E RE + +E +R+Q+L +Q+++ Q ++Q R E+ + ++QL +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEIL----DARAQDSVGRSDNEMCELD 303
++ R QE+ Q E + E+ R + L + R + + R + E E +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 304 PGQ---------FIDRARALIREQEMAENKPKR-EGNNKERDHGPNSLQPEGKHLAETLK 353
+ +R + L++ +E E + ++ +ER + E + L + LK
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673
Query: 354 QE 355
+E
Sbjct: 674 RE 675
Score = 37.7 bits (86), Expect = 0.039
Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 10/143 (6%)
Query: 202 ESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIY 261
E +R+ + Q +Q QQ Q L+ ++E+ RE+ R+ QQ + + QL+ + +
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 262 DSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMA 321
D ++ E+ L +R E + R + R E +L +R +R QE
Sbjct: 1308 KRRDRKSQEEKQL----LREEREEKRRRQETDRKFREEEQL----LQEREEQPLRRQE-- 1357
Query: 322 ENKPKREGNNKERDHGPNSLQPE 344
++ RE + ++ G L+ E
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEE 1380
Score = 37.4 bits (85), Expect = 0.050
Identities = 36/160 (22%), Positives = 70/160 (43%), Gaps = 29/160 (18%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQK-REERRQLKQQ 242
LR E ER+ + R RE + +Q ++ ++ QQL +++K REE +Q+++Q
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 243 ------LEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSD 296
LE+ Q+ ++ KF + ++L R + + R +
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFRE--------------------EEQLLQEREEQQLHRQE 1482
Query: 297 NEMCELDPGQFIDRAR--ALIREQEMAENKPKREGNNKER 334
+ L+ Q + R REQE+ +P+R+ +E+
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Score = 37.0 bits (84), Expect = 0.066
Identities = 31/183 (16%), Positives = 77/183 (42%), Gaps = 7/183 (3%)
Query: 159 DEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ 218
+E R ++ R E ++ L E ER E + +++++ + +Q
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 219 QSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDS 278
+ ++ R+E + E R+QL + E +++ +QL+ + + + +E+ L E
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL-EQR 671
Query: 279 MRSEILDARAQDSVGRSDNEMC------ELDPGQFIDRARALIREQEMAENKPKREGNNK 332
++ E + R + + + E + Q+ + A R+ ++ K+EG +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 333 ERD 335
++
Sbjct: 732 RQE 734
Score = 36.2 bits (82), Expect = 0.11
Identities = 36/152 (23%), Positives = 71/152 (46%), Gaps = 9/152 (5%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQL 243
LR E ER+ + R E K +++ +Q+ +QL + +K E QL+ +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELD 303
E+ Q + RQ +++ ++ + E +E S++S R R ++ + R + E +L
Sbjct: 1760 EEQQLR-RQERDRKFREEEQLRQEREEQQLRSQESDRK----FREEEQL-RQEREEQQLR 1813
Query: 304 PGQFIDRARALIREQEMAENKPKREGNNKERD 335
P Q + R E+E + + + + +ERD
Sbjct: 1814 PQQRDGKYR---WEEEQLQLEEQEQRLRQERD 1842
Score = 35.0 bits (79), Expect = 0.25
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 188 ENEREMAPQSVSPRESYREN---KRKQKLPQQQQ----QSFQQLVSARKEQKREERRQLK 240
E E E Q + + R +R+Q+L ++QQ Q ++ R+EQ+ +QL+
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 241 QQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMC 300
++ E+ + + + QE+ Q E + E++ R E R + + R E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE--QERRKQQLKRDQEEE- 483
Query: 301 ELDPGQFIDRARAL-IREQEMAENKPKRE----GNNKERDHGPNSLQPEGKHLAETLKQE 355
R R L + E+E E + +RE +ER Q E + L + L+ E
Sbjct: 484 --------RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Score = 35.0 bits (79), Expect = 0.25
Identities = 37/165 (22%), Positives = 72/165 (43%), Gaps = 14/165 (8%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK--QQLED 245
E ER+ ++ + + +E RK++ Q+++ Q K +++E+ RQ + +QL+
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 246 MQKQ-LRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDP 304
++Q LR+ +EK + D+ E+ + E + R + + E EL
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 305 GQFIDRARALIREQEMAENKPKREGNNKERDH-GPNSLQPEGKHL 348
+ EQ + E + KR ER + + LQ E + L
Sbjct: 999 EE----------EQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Score = 35.0 bits (79), Expect = 0.25
Identities = 39/176 (22%), Positives = 84/176 (47%), Gaps = 21/176 (11%)
Query: 161 HLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQS 220
H R ++ R E + + LR E +R+ + + R +R++K Q++QQ
Sbjct: 1663 HDRDRKFREEEQL--LQEGEEQQLRRQERDRKFREEE----QQLRRQERERKFLQEEQQL 1716
Query: 221 FQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMR 280
+Q + E+K E QL+Q+ E Q+QLR+ QE++ +I + + + E +R
Sbjct: 1717 RRQEL----ERKFREEEQLRQETE--QEQLRR-QERYRKILEEEQLRPERE----EQQLR 1765
Query: 281 SEILDAR-AQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
+ D + ++ R + E +L + + R E+++ + + +++ ++RD
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQL---RSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Score = 33.9 bits (76), Expect = 0.56
Identities = 42/189 (22%), Positives = 82/189 (43%), Gaps = 15/189 (7%)
Query: 153 DMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENER-EMAPQSVSPRESYRENKRKQ 211
D DR E + ++ R E + L + R E + + + R + +Q
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611
Query: 212 KLPQQQQQSF---QQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+L Q++ + F +QL+ R+EQ+ + + ++ LE+ + QLR+ QE+ Q+ D +
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE-EPQLRR-QEREQQLRHDRDRKF 1669
Query: 269 DEDGNL----SEDSMRSEILDAR---AQDSVGRSDNEMCELDPGQFIDR--ARALIREQE 319
E+ L E +R + D + + + R + E L Q + R RE+E
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 320 MAENKPKRE 328
+ ++E
Sbjct: 1730 QLRQETEQE 1738
Score = 32.0 bits (71), Expect = 2.1
Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 10/109 (9%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR--------EERRQL 239
E R+ Q + +S R +R P ++Q +QL A + Q+R EE+ Q
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL-RAEERQQREQRFLPEEEEKEQR 820
Query: 240 KQQLEDMQKQLRQL-QEKFYQIYDSTDSENDEDGNLSEDSMRSEILDAR 287
++Q + +K+L+ L +E+ Q + +E+ L ED R + R
Sbjct: 821 RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Score = 31.2 bits (69), Expect = 3.6
Identities = 29/160 (18%), Positives = 79/160 (49%), Gaps = 12/160 (7%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQL 243
LR ++++++ Q + + R+ +++++ QQ+ + F + +E+++E +R+ ++
Sbjct: 1258 LRDRQSQQDL--QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGNL----SEDSMRSEILDARAQDSVGRSDNEM 299
E+ Q + +EK + TD + E+ L E +R + D + ++ R +
Sbjct: 1316 EEKQLLREEREEK--RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373
Query: 300 CE-LDPGQFI---DRARALIREQEMAENKPKREGNNKERD 335
+ L+ Q + +R R ++E++ + + + ++RD
Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Score = 30.8 bits (68), Expect = 4.7
Identities = 37/177 (20%), Positives = 75/177 (42%), Gaps = 13/177 (7%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQ----KREERRQL--KQQL 243
E E Q ++ +R+ + ++ L ++QQ Q+ +EQ + ER+ L +QQL
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGN---LSEDSMRSEILDARAQDSVGRSDNEMC 300
Q+Q + LQE+ + +D + E+ +R E R + + R + +
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE----REEQQLSRQERDRK 1580
Query: 301 ELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELN 357
Q + R + E + ++EG + R + + + L E +Q+L+
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLH 1637
Score = 30.0 bits (66), Expect = 8.0
Identities = 26/119 (21%), Positives = 56/119 (47%), Gaps = 16/119 (13%)
Query: 184 LRGNENEREMAPQSVSPRESYRENKRKQKL-PQQQQQSF----QQLVSARKEQK----RE 234
LR E++R+ + E R+ + +Q+L PQQ+ + +QL +EQ+ R+
Sbjct: 1788 LRSQESDRKFREE-----EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 235 ERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVG 293
+ + ++Q +K R+ QE + + + + + L E+ +R + + + VG
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQE--EEQKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1338 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1453
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1514 E-VELASRVKAEAEAA 1528
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1707
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1708 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2634
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2404 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2460 EKLQQE 2465
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2601
Query: 247 QKQLR 251
++Q R
Sbjct: 2602 EEQHR 2606
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2027
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1342 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1457
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1518 E-VELASRVKAEAEAA 1532
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1711
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1712 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2638
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2639 GPAAEAEPEHSFDGLRRKVSAQRLQE 2664
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2408 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2464 EKLQQE 2469
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2605
Query: 247 QKQLR 251
++Q R
Sbjct: 2606 EEQHR 2610
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2031
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1338 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1453
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1514 E-VELASRVKAEAEAA 1528
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1707
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1708 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2634
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2635 GPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2404 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2460 EKLQQE 2465
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2601
Query: 247 QKQLR 251
++Q R
Sbjct: 2602 EEQHR 2606
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2027
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1306 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1421
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1482 E-VELASRVKAEAEAA 1496
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1675
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1676 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2602
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2603 GPAAEAEPEHSFDGLRRKVSAQRLQE 2628
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2372 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2428 EKLQQE 2433
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2569
Query: 247 QKQLR 251
++Q R
Sbjct: 2570 EEQHR 2574
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 1995
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1475 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1590
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1651 E-VELASRVKAEAEAA 1665
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1844
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1845 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2771
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQE 2797
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2541 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2597 EKLQQE 2602
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2738
Query: 247 QKQLR 251
++Q R
Sbjct: 2739 EEQHR 2743
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2164
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1316 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1431
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1492 E-VELASRVKAEAEAA 1506
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1685
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1686 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2612
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQE 2638
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2382 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2438 EKLQQE 2443
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2579
Query: 247 QKQLR 251
++Q R
Sbjct: 2580 EEQHR 2584
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2005
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1324 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1439
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1500 E-VELASRVKAEAEAA 1514
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1693
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1694 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2620
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2621 GPAAEAEPEHSFDGLRRKVSAQRLQE 2646
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2390 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2446 EKLQQE 2451
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2587
Query: 247 QKQLR 251
++Q R
Sbjct: 2588 EEQHR 2592
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2013
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 46.6 bits (109), Expect = 8e-05
Identities = 51/208 (24%), Positives = 86/208 (41%), Gaps = 39/208 (18%)
Query: 160 EHLRAKRARVENIIRGMSHSPSVALRGNENE-REMAPQSVSPRESYRENKRKQKLPQQ-- 216
E L A +AR E R S L RE+A ++ R E KR+++L ++
Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851
Query: 217 -QQQSFQQLVSARK------------------EQKREERRQLKQQLEDMQKQLRQLQE-- 255
+Q++ + V A K ++K E +L++ ED Q R+L+E
Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 256 ---------KFYQIYDSTDSENDEDGNLSEDSMR------SEILDARAQDSVGRSDNEMC 300
+ Q+ ++DSE + L ED++R EIL +A +
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971
Query: 301 ELDPGQFIDRARALIREQEMAENKPKRE 328
EL+ G+ A +R +E AE + R+
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Score = 42.4 bits (98), Expect = 0.002
Identities = 49/196 (25%), Positives = 78/196 (39%), Gaps = 22/196 (11%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
S LR E E +A Q R RE + + ++Q+ + + K Q E ++L+
Sbjct: 1365 SETLRRMEEEERLAEQQ---RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421
Query: 241 QQLE-----------DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQ 289
Q+++ D Q+Q R +QE+ Q+ S+++E +E + RS L +
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEE 1480
Query: 290 DSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER------DHGPNSLQP 343
V R E E G +AL E AE + ++ ER D Q
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 344 EGKHLAETLKQELNTA 359
E LA +K E A
Sbjct: 1541 E-VELASRVKAEAEAA 1555
Score = 35.8 bits (81), Expect = 0.15
Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 11/168 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQ 216
L +EH+ + R E R + + R E ERE+ + E+ R + +++ QQ
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 217 QQQSFQQLVSARKEQKREERRQLKQQLEDM-QKQLRQLQ-EKFYQIYDSTDSENDEDGNL 274
+ + + ++E +RE RR+ K + + + Q++L + + EK Q+ + T +
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ------- 1734
Query: 275 SEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
+ E++ RA+ G ++ E + + A A ++++ E
Sbjct: 1735 -RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Score = 34.3 bits (77), Expect = 0.43
Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 192 EMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKE-------------QKREERRQ 238
++ V+ + RE +++Q+ QQ +Q Q+LV++ +E +K+EE +Q
Sbjct: 2545 QLFQDEVAKAQQLREEQQRQQ--QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Query: 239 LKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRS--D 296
L+QQ ++ L + ++ + + ++ SE+ S++ + + GR D
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN-GRDALD 2661
Query: 297 NEMCELDPGQFIDRARALIREQEMAE 322
E +P D R + Q + E
Sbjct: 2662 GPAAEAEPEHSFDGLRRKVSAQRLQE 2687
Score = 32.0 bits (71), Expect = 2.1
Identities = 37/186 (19%), Positives = 85/186 (45%), Gaps = 15/186 (8%)
Query: 181 SVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLK 240
SVA + R++A + ++ + + E K+K+ Q+ + + + +Q++E ++
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
Query: 241 QQLEDMQKQL-RQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEI-------LDARAQDSV 292
++L++ ++Q+ +QL E+ + ++E +S ++ R ++ ARA++
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
Query: 293 GRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQ---PEGKHLA 349
R + E+ G+ + R + QE E ++ DH L+ E +
Sbjct: 2431 QRFRKQAEEI--GEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 350 ETLKQE 355
E L+QE
Sbjct: 2487 EKLQQE 2492
Score = 31.6 bits (70), Expect = 2.8
Identities = 18/65 (27%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR---EERRQLKQQLEDM 246
E+E S E+ R ++ +++Q+ QQL R++Q+ EE ++L++QL+ +
Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2628
Query: 247 QKQLR 251
++Q R
Sbjct: 2629 EEQHR 2633
Score = 30.4 bits (67), Expect = 6.2
Identities = 45/231 (19%), Positives = 99/231 (42%), Gaps = 26/231 (11%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
+L E R +R E + + ++ A +R+ A + V ++ E R+ + +
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAA-----RQRKAALEEVERLKAKVEEARRLR-ER 2054
Query: 216 QQQQSFQQL----VSARKEQKREERRQ---LKQQLEDMQKQLRQLQEKFYQIYDSTDSEN 268
+Q+S +QL +A+K + EE+ ++Q+ +++Q+ L+Q Q Q+ ++
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 269 DEDGNLSEDSMRSEILDARAQDSVGRSDN-EMCELDPGQFIDRARALIR------EQEMA 321
E +++E A+++ V ++ + + Q +A+A EQE A
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 322 ENKPKREGNNKERDHGPNSLQPEGKHLAETLK------QELNTAMSQVVDT 366
+ +++ ++ K +TL+ QEL T Q+ +T
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 15/193 (7%)
Query: 153 DMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQK 212
D R D H +R R + R R + E+E Q RE+ RE +R +
Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRE-----RDRQREKERNRQKERERETEREGERGRD 140
Query: 213 LPQQQQQSFQQLVSARKEQKRE---------ERRQLKQQLEDMQKQLRQLQEKFYQIYDS 263
Q+ ++ A KE++R+ ER + K++ + +Q R+ +E+ + +
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200
Query: 264 TDSENDEDGNLSEDSMRSEI-LDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAE 322
T+ + E G E +E + + Q R E + + +R RA RE E +
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 323 NKPKREGNNKERD 335
+ + +++RD
Sbjct: 261 ERERERDRDRDRD 273
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/154 (20%), Positives = 65/154 (42%), Gaps = 3/154 (1%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLE 244
R + ERE RE R+ +++ K + + ++ R+ + ER++ +
Sbjct: 173 RNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER 232
Query: 245 DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNE---MCE 301
D Q++ + +EK + +++ E + D + R D R ++ ++D + E
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 302 LDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
D R R RE+E N+ + +ER+
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERE 326
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/161 (21%), Positives = 69/161 (42%), Gaps = 11/161 (6%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR----------E 234
R + ERE A + + R+ RE +R + + ++Q ++ + RK Q+R
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKR 301
Query: 235 ERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGR 294
ER++ +++ + ++ + +E+ + ++E D + R +D GR
Sbjct: 302 ERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGR 361
Query: 295 SDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
E + + +R R RE+E E R+ KER+
Sbjct: 362 EGRRQAERERERERERDRQSAREREERERDRDRD-RQKERE 401
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/135 (25%), Positives = 60/135 (44%), Gaps = 4/135 (2%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARK--EQKREERRQLKQQ 242
R E ERE ++ RE RE KRK++ ++++ Q R+ E++RE R+ +Q
Sbjct: 321 RERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQ 380
Query: 243 LEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCEL 302
+++ + +++ Q +E D DG + R D ++ GR E
Sbjct: 381 SAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESER--GRERGREREK 438
Query: 303 DPGQFIDRARALIRE 317
G+ DR R R+
Sbjct: 439 QKGRERDRERQTDRQ 453
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/201 (16%), Positives = 83/201 (41%), Gaps = 10/201 (4%)
Query: 146 RPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYR 205
R Q + +R + + R R R + +R+ ++ RE+ R
Sbjct: 240 REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299
Query: 206 ENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTD 265
+ +R+++ ++++++ ++ +E++RE +R+ ++ E +++ R+ Q + +
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR------ 353
Query: 266 SENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKP 325
N + G E R +D + E E D DR R RE++ +++
Sbjct: 354 ERNRQTGREGRRQAERERERERERDRQSAREREERERDR----DRDRQKERERQTEKDRD 409
Query: 326 KREGNNKERDHGPNSLQPEGK 346
+ K+R+ + G+
Sbjct: 410 GQRETEKQREREKDRESERGR 430
Score = 35.8 bits (81), Expect = 0.15
Identities = 30/149 (20%), Positives = 62/149 (41%), Gaps = 12/149 (8%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
+ ER R+ +RE +R ++ +++Q ++ KE+ R++ R+ + + E +
Sbjct: 78 KRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER 137
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQF 307
+ RQ TD + + + + R D Q R+ + E + +
Sbjct: 138 GRDRQ-----------TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQ 186
Query: 308 IDRARALIREQE-MAENKPKREGNNKERD 335
R R RE+E E++ G +ER+
Sbjct: 187 ERRERERQREKENKTEDRHSERGRERERE 215
Score = 35.0 bits (79), Expect = 0.25
Identities = 36/169 (21%), Positives = 70/169 (41%), Gaps = 6/169 (3%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLE 244
R + ERE + R++ RE RK++ +++ + ++ +++ RE+ R+ + E
Sbjct: 56 RNRQKERERRREK---RQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112
Query: 245 -DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELD 303
D Q++ + ++K + + E D R DA + + +
Sbjct: 113 RDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTE 172
Query: 304 PGQFIDRARALIREQEMAENKPKREGNNKERD-HGPNSLQPEGKHLAET 351
+ +R R R QE E + +RE NK D H + E + ET
Sbjct: 173 RNRQKEREREKNR-QERRERERQREKENKTEDRHSERGRERERERETET 220
Score = 35.0 bits (79), Expect = 0.25
Identities = 30/159 (18%), Positives = 72/159 (45%), Gaps = 6/159 (3%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E ER+ + R++ RE +R+ + +Q+++ ++ R+E++R+ R+ + + ED
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQ--REKENKTEDRH 205
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQF 307
+ + +E+ + T++E + D R + Q R+ E D +
Sbjct: 206 SERGRERER--ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER- 262
Query: 308 IDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGK 346
+R R R+++ + + +R+ + K + + E K
Sbjct: 263 -ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERK 300
Score = 32.0 bits (71), Expect = 2.1
Identities = 30/156 (19%), Positives = 67/156 (42%), Gaps = 8/156 (5%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQ----LK 240
R E +R R+ RE +R+++ +++ + ++ + +KE++RE R+
Sbjct: 81 RRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRD 140
Query: 241 QQLEDMQKQLRQLQ-EKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEM 299
+Q + +++ RQ EK + + + + N ++ R + R + R
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200
Query: 300 CELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
E + +R R RE+E ++ ++ERD
Sbjct: 201 TE---DRHSERGRERERERETETETERKRQTDRERD 233
Score = 30.0 bits (66), Expect = 8.0
Identities = 31/168 (18%), Positives = 71/168 (42%), Gaps = 11/168 (6%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR--EERRQLKQQ 242
R E ERE ++ R++ RE R++K +++++ ++ ++ +E +R E R+ +
Sbjct: 210 RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDR- 268
Query: 243 LEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCEL 302
D + RQ + + TD + ++ R + R+ E
Sbjct: 269 --DRDRDRRQKERE-----RQTDRKRQRRTERDRETERKRERQRERERERERNRKRERER 321
Query: 303 DPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAE 350
+ + +R R R++E + ++ +R+ + + EG+ AE
Sbjct: 322 ERERERERQRETERDREKERERKRKRQTEMDRERNRQTGR-EGRRQAE 368
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/190 (22%), Positives = 86/190 (45%), Gaps = 12/190 (6%)
Query: 174 RGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR 233
R + P RG + + E P S S E R + ++ + ++L + R+ ++
Sbjct: 277 RKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Query: 234 EERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVG 293
EE R+L++Q ++ +++ R+ ++ S S DE L ED E + R + G
Sbjct: 337 EELRRLREQEKEEKERRRERADRGEAERGSGGSSGDE---LRED---DEPVKKRGRKGRG 390
Query: 294 RSDNEMCELDPGQFIDR-ARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETL 352
R + +P ++R A+ ++ + + +P R+ KE+ ++PE K A+ +
Sbjct: 391 RGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEK-----RVRPEEKQQAKPV 445
Query: 353 KQELNTAMSQ 362
K E S+
Sbjct: 446 KVERTRKRSE 455
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/190 (22%), Positives = 86/190 (45%), Gaps = 12/190 (6%)
Query: 174 RGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR 233
R + P RG + + E P S S E R + ++ + ++L + R+ ++
Sbjct: 277 RKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQE 336
Query: 234 EERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVG 293
EE R+L++Q ++ +++ R+ ++ S S DE L ED E + R + G
Sbjct: 337 EELRRLREQEKEEKERRRERADRGEAERGSGGSSGDE---LRED---DEPVKKRGRKGRG 390
Query: 294 RSDNEMCELDPGQFIDR-ARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETL 352
R + +P ++R A+ ++ + + +P R+ KE+ ++PE K A+ +
Sbjct: 391 RGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEK-----RVRPEEKQQAKPV 445
Query: 353 KQELNTAMSQ 362
K E S+
Sbjct: 446 KVERTRKRSE 455
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 45.4 bits (106), Expect = 2e-04
Identities = 92/433 (21%), Positives = 177/433 (40%), Gaps = 83/433 (19%)
Query: 206 ENKRKQKLPQQQQQSFQ---QLVSARK---EQKREERRQLKQQLEDMQKQLRQLQEKFYQ 259
E R+Q+L QQQ+++ + QL++ R+ E+++E+RR+L++Q + +K+LR+ QE+ +
Sbjct: 366 EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQR 424
Query: 260 IYDSTDSENDEDGNLSE---DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIR 316
+ +E+ +E + +R ++ + + Q + + + + ++ R +
Sbjct: 425 RHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQ---QQLLHEQALLLEYKRKQLE 481
Query: 317 EQEMAENKPKREGNNKERD------HGPNSLQPEGK----HLAETLKQELNTAMSQVVDT 366
EQ AE ++ +ERD H +P K H E + A ++ +
Sbjct: 482 EQRQAERLQRQ--LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPH 539
Query: 367 VVKVFSAKPSRQVPQVF---PPLQIPQARFAVNGENHNFHTANQRLQCFGD-VIIPNPLD 422
+V V S P+ Q P + + A+N +H Q + +P ++
Sbjct: 540 LVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIE 599
Query: 423 TFGNVQMASSTDQ---------TEALPLVVRKNS-SDQSASGPAAGG-----------HH 461
F + T P + RKNS + SA GP G
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659
Query: 462 QPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDT 521
+P+ +SPL T+ ++S+ P P S G+ GS +G S + TR
Sbjct: 660 EPILESPLQRTSSGSSSSSSTPSSQP------SSQGGSQPGSQAG-------SSERTRVR 706
Query: 522 TSLRTKMSSHHLSHHPCS-----------PAHPPSTAEGL--SLSLIKSECGDL------ 562
+ +++ S L H P P+ P S + + L+ + E +L
Sbjct: 707 ANSKSE-GSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETN 765
Query: 563 QDMSEISPYSGSA 575
+ M +++ YS S+
Sbjct: 766 RPMKKVTDYSSSS 778
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
RL ++ R K R + H +R E R + R E +R+ ++ Q
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQ 462
Query: 216 QQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQ 252
QQ Q L+ K ++ EE+R Q E +Q+QL+Q
Sbjct: 463 QQLLHEQALLLEYKRKQLEEQR----QAERLQRQLKQ 495
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/158 (22%), Positives = 80/158 (50%), Gaps = 16/158 (10%)
Query: 201 RESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLR-QLQEKFYQ 259
R+ E R+QK+ + +++ ++ V ++E++ + Q ++++E M+++ + Q+++KF Q
Sbjct: 547 RKEEAEQLRRQKVEEDKRRRLEE-VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Query: 260 IYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQE 319
I + T+ +E L+E+ + + + ++ R E + AR L Q+
Sbjct: 606 IDEKTEKAKEE--RLAEEKAKKKAAAKKMEEVEARRKQE----------EEARRLRWLQQ 653
Query: 320 MAENKPKREGNNKERDHGPNSLQ--PEGKHLAETLKQE 355
E + +E K+++ L+ E K LAE +QE
Sbjct: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
Score = 43.9 bits (102), Expect = 5e-04
Identities = 35/148 (23%), Positives = 78/148 (52%), Gaps = 12/148 (8%)
Query: 149 MSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENK 208
+ Q + +R E L+ K+ + +R + + +A + + RE + RE +
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE---------QERREQE 701
Query: 209 RKQKLPQQQQQSFQQLVSARKEQKRE-ERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSE 267
R+++ ++Q++ Q+ A +E++RE ER Q +++L++ +K LR LQ++ Q +
Sbjct: 702 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALR-LQKEQLQRELEEKKK 760
Query: 268 NDEDGNLSEDSMRSEILDARAQDSVGRS 295
+E L+E ++ E + +A+++ G S
Sbjct: 761 KEEQQRLAERQLQEE-QEKKAKEAAGAS 787
Score = 35.4 bits (80), Expect = 0.19
Identities = 33/179 (18%), Positives = 82/179 (45%), Gaps = 13/179 (7%)
Query: 159 DEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ 218
+E L ++A+ + + M A R E E E R + QK +++Q
Sbjct: 615 EERLAEEKAKKKAAAKKMEEVE--ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
Query: 219 QSFQQLVSARK--EQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSE 276
+ ++ A++ EQ+ +ERR+ +++ ++ ++Q R+ QE+ Q + E + +
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE----Q 728
Query: 277 DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
+ +++E + + ++ R E + + ++ + +Q +AE + + E K ++
Sbjct: 729 ERLQAE-RELQEREKALRLQKEQLQRE----LEEKKKKEEQQRLAERQLQEEQEKKAKE 782
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/303 (18%), Positives = 122/303 (40%), Gaps = 35/303 (11%)
Query: 70 LRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDIC 129
L +++KR + F A I + K+N K G + ++ SS+ S
Sbjct: 275 LEEVMKRVREAQS----FISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSH------- 323
Query: 130 SNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNEN 189
S R R Q D R H + ++R R SHS +
Sbjct: 324 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS--------RD 375
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQ 249
+R+ + + +E +E R+++ +++++ ++ R + K ++ + K + +D +K
Sbjct: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEK---ERGKNKDRDKEREKDREKDKEKD 432
Query: 250 LRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDA------------RAQDSVGRSDN 297
+ +EK ++ + E ++D + RS+ +D R+ ++ RS +
Sbjct: 433 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 492
Query: 298 EMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELN 357
E + +R+ R + + K R + + R+ + E H++E ++E +
Sbjct: 493 SSRERRRRRSRSSSRSP-RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 551
Query: 358 TAM 360
T+M
Sbjct: 552 TSM 554
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 45.1 bits (105), Expect = 2e-04
Identities = 56/303 (18%), Positives = 122/303 (40%), Gaps = 35/303 (11%)
Query: 70 LRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDIC 129
L +++KR + F A I + K+N K G + ++ SS+ S
Sbjct: 159 LEEVMKRVREAQS----FISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSH------- 207
Query: 130 SNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNEN 189
S R R Q D R H + ++R R SHS +
Sbjct: 208 SRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS--------RD 259
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQ 249
+R+ + + +E +E R+++ +++++ ++ R + K ++ + K + +D +K
Sbjct: 260 KRKDTREKIKEKERVKEKDREKEREREKEREKEK---ERGKNKDRDKEREKDREKDKEKD 316
Query: 250 LRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDA------------RAQDSVGRSDN 297
+ +EK ++ + E ++D + RS+ +D R+ ++ RS +
Sbjct: 317 REREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRS 376
Query: 298 EMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELN 357
E + +R+ R + + K R + + R+ + E H++E ++E +
Sbjct: 377 SSRERRRRRSRSSSRSP-RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 435
Query: 358 TAM 360
T+M
Sbjct: 436 TSM 438
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/150 (20%), Positives = 70/150 (46%), Gaps = 4/150 (2%)
Query: 185 RGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLE 244
RG E ERE Q ++ REN+ +Q+ +++ R+ QK +R++ +++
Sbjct: 13 RGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERET 72
Query: 245 DMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDP 304
+ + + ++ +++ + TD E D+D + + R + GR ++ E +
Sbjct: 73 ERETERQRERQRQRERKRQTDRERDKDRD--RERKRETDRNRERNRKGGRERDKQTERER 130
Query: 305 GQFIDRARALIREQEMAENKPKREGNNKER 334
+ +R R RE+E + ++ ++ER
Sbjct: 131 DR--ERERQRQRERERQRQRERKRETDRER 158
Score = 36.6 bits (83), Expect = 0.086
Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 1/110 (0%)
Query: 146 RPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYR 205
R T + D DR + R R N G R + ERE Q R+ R
Sbjct: 90 RQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTE-RERDRERERQRQRERERQRQR 148
Query: 206 ENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQE 255
E KR+ +Q+ ++ RK+++++ER++ K++ + + + R+ E
Sbjct: 149 ERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKRKWGE 198
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 44.7 bits (104), Expect = 3e-04
Identities = 75/345 (21%), Positives = 144/345 (41%), Gaps = 56/345 (16%)
Query: 206 ENKRKQKLPQQQQQSFQ---QLVSARK---EQKREERRQLKQQLEDMQKQLRQLQEKFYQ 259
E R+Q+L QQQ+++ + QL++ R+ E+++E+RR+L++Q + +K+LR+ QE+ +
Sbjct: 366 EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQ-QRREKELRKQQEREQR 424
Query: 260 IYDSTDSENDEDGNLSE---DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIR 316
+ +E+ +E + +R ++ + + Q + + + + ++ R +
Sbjct: 425 RHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQ---QQLLHEQALLLEYKRKQLE 481
Query: 317 EQEMAENKPKREGNNKERD------HGPNSLQPEGK----HLAETLKQELNTAMSQVVDT 366
EQ AE ++ +ERD H +P K H E + A ++ +
Sbjct: 482 EQRQAERLQRQ--LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPH 539
Query: 367 VVKVFSAKPSRQVPQVF---PPLQIPQARFAVNGENHNFHTANQRLQCFGD-VIIPNPLD 422
+V V S P+ Q P + + A+N +H Q + +P ++
Sbjct: 540 LVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIE 599
Query: 423 TFGNVQMASSTDQ---------TEALPLVVRKNS-SDQSASGPAAGG-----------HH 461
F + T P + RKNS + SA GP G
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659
Query: 462 QPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSG 506
+P+ +SPL T+ ++S+ P P S G+ GS +G
Sbjct: 660 EPILESPLQRTSSGSSSSSSTPSSQP------SSQGGSQPGSQAG 698
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/97 (27%), Positives = 43/97 (44%), Gaps = 5/97 (5%)
Query: 156 RLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
RL ++ R K R + H +R E R + R E +R+ ++ Q
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEE-QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQ 462
Query: 216 QQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQ 252
QQ Q L+ K ++ EE+R Q E +Q+QL+Q
Sbjct: 463 QQLLHEQALLLEYKRKQLEEQR----QAERLQRQLKQ 495
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 44.3 bits (103), Expect = 4e-04
Identities = 35/165 (21%), Positives = 78/165 (47%), Gaps = 19/165 (11%)
Query: 201 RESYRENKRKQKLPQQQQQSFQQLVSARKEQK-REERRQLKQQLEDMQKQLRQLQEKFYQ 259
RE + + ++K+ +Q+++ Q+ R+E+K RE+ ++++Q E MQ+Q ++ E+ +
Sbjct: 360 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 419
Query: 260 IYDSTD--SENDEDGNLSEDSMRSEILDARAQ---------------DSVGRSDNEMCEL 302
+++ + E +E E+ +R + R Q + +G + +MCE
Sbjct: 420 MWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ 479
Query: 303 DPGQFIDRARALIREQEMAENKPK-REGNNKERDHGPNSLQPEGK 346
+ + +E+++ E + K RE K R+ + E K
Sbjct: 480 EAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 524
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/156 (16%), Positives = 69/156 (44%), Gaps = 9/156 (5%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E RE E E + K +++ Q ++ + ++E+ RE+ +++++Q E ++
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 248 KQLRQLQEKFYQI---------YDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNE 298
+Q +QE+ ++ ++ E +E E+ +R + R Q+ R E
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 299 MCELDPGQFIDRARALIREQEMAENKPKREGNNKER 334
M + + ++ + ++E + + ++ +E+
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Score = 38.5 bits (88), Expect = 0.023
Identities = 35/207 (16%), Positives = 95/207 (45%), Gaps = 14/207 (6%)
Query: 157 LCDEHLRAKRARVENIIRGMSHSPSVALRGNE--NEREMAPQSVSPRESYRENKRKQKLP 214
L + L+A+ + ++ +S + NE N + R+ + +R++K+
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQ 305
Query: 215 QQQQQSFQQLVSARKEQ-----KREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSEND 269
+Q+++ +Q R+++ K E+ R+ ++ + + ++++R+L+EK +++
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK---MHEQEKIREQ 362
Query: 270 EDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQE--MAENKPKR 327
E+ E+ +R + + + R + ++ E + + I +++EQE M E + K
Sbjct: 363 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE--EKIREQEEMMQEQEEKMGEQEEKM 420
Query: 328 EGNNKERDHGPNSLQPEGKHLAETLKQ 354
+E ++ + + + E K+
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKK 447
Score = 37.7 bits (86), Expect = 0.039
Identities = 34/164 (20%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKR----EERRQLKQQL 243
E E +M Q E + +R++++ ++++ ++L EQ++ EE+RQ ++++
Sbjct: 313 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 244 EDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELD 303
+ +K RQ QE + E +E E+ M+ + ++ +G + +M E +
Sbjct: 373 REQEK--RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ------EEKMGEQEEKMWEQE 424
Query: 304 PGQFIDRARALIREQEMAENKPK-REGNNKERDHGPNSLQPEGK 346
+ +E+++ E + K RE K R+ + E K
Sbjct: 425 EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Score = 32.0 bits (71), Expect = 2.1
Identities = 25/113 (22%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDM- 246
E RE E E + K + + Q ++ + ++E+ RE+ +++++Q E +
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 247 -QKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNE 298
Q+++ Q QE+ + E +E E+ MR + R Q+ R E
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
Score = 31.6 bits (70), Expect = 2.8
Identities = 17/76 (22%), Positives = 44/76 (57%), Gaps = 6/76 (7%)
Query: 190 EREMAPQSVSPRESYRENKRKQKLPQQQQQSF---QQLVSARKEQKREERRQLKQQLEDM 246
E ++ Q RE + + ++++ Q+Q++ ++ + ++E+ +E+ ++++Q E M
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 553
Query: 247 QKQ---LRQLQEKFYQ 259
++Q LRQ +EK +
Sbjct: 554 REQEVRLRQQEEKMQE 569
>gi|4503351 DNA (cytosine-5-)-methyltransferase 1 isoform b [Homo
sapiens]
Length = 1616
Score = 43.9 bits (102), Expect = 5e-04
Identities = 53/260 (20%), Positives = 109/260 (41%), Gaps = 20/260 (7%)
Query: 90 ATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDI-CSNSSRDSPPECLSPFGRPT 148
A + S L K+ +NG + + +G G++ E + +SPP+ LS P
Sbjct: 80 AKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPR 139
Query: 149 MSQFDMDRLCDE----HLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESY 204
S+ D + + + K R I + P+ E+ER + +S+ +
Sbjct: 140 RSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKD 199
Query: 205 RENKRKQ---------KLPQQQQQSFQQLVSARKEQKREER--RQLKQQLEDMQKQLRQL 253
++ KR++ LP ++ + + KE++R+E+ ++L+ Q ++ + +
Sbjct: 200 QDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLK 259
Query: 254 QEKFYQIYDSTDSENDEDGN-LSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRAR 312
+E + ++ DEDG+ E RS+ D A+ + E +++P Q D
Sbjct: 260 EEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPE--KVNP-QISDEKD 316
Query: 313 ALIREQEMAENKPKREGNNK 332
+E++ + PK K
Sbjct: 317 EDEKEEKRRKTTPKEPTEKK 336
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 43.5 bits (101), Expect = 7e-04
Identities = 38/182 (20%), Positives = 89/182 (48%), Gaps = 12/182 (6%)
Query: 206 ENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQL-RQLQEKFYQIYDST 264
E ++++ L ++++ ++ +E+ REE + K++ E +KQ+ ++ +EK + +
Sbjct: 2236 ELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKK 2295
Query: 265 DSENDEDGNLSEDSMRSEILDARAQDSVG--RSDNEMCELDPGQFIDRARALIREQEMAE 322
E E + E+ + EI+ +S+ + E C L+ + +DR + ++++++ +
Sbjct: 2296 KEEVQEKEEVFEE--KEEIMSEEETESLSDEEEEEESCSLE--EEVDREKEILKKEKQFK 2351
Query: 323 NKPKREGNNKERDHGPNSLQ--PEGKHLA---ETLKQELNTAMSQVVDTVVKVFSAKPSR 377
+ +R + + R+ + L+ P GK A LK L MS ++ K P +
Sbjct: 2352 LQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEK 2411
Query: 378 QV 379
Q+
Sbjct: 2412 QI 2413
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 43.1 bits (100), Expect = 0.001
Identities = 48/230 (20%), Positives = 94/230 (40%), Gaps = 15/230 (6%)
Query: 153 DMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQK 212
D +R + L +RAR R R +++RE + RE RE +R+++
Sbjct: 698 DREREKERELERERAREREREREKERDRERD-RDRDHDRERERERERDREKEREREREER 756
Query: 213 LPQQQQQSFQQLVSARKEQKREER---RQLKQQLEDMQKQLRQLQEKFYQIYDSTDSEND 269
+++++ ++ R+ ++ ER R+ ++ ED K +EK +I + + +
Sbjct: 757 ERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDG 816
Query: 270 EDGNLSEDSMRSEILDARAQDSVGR------SDNEMCELDPGQFIDRARALIREQEMAEN 323
D S+ R+E + Q R SD D + ++R QE
Sbjct: 817 HDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSL 876
Query: 324 KPK-----REGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVV 368
P R+G KE D P + ++ + LK+++++ Q T +
Sbjct: 877 SPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEI 926
Score = 33.9 bits (76), Expect = 0.56
Identities = 31/176 (17%), Positives = 76/176 (43%), Gaps = 5/176 (2%)
Query: 159 DEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ 218
++ L R E + + R + ERE + RE R+ +R+++ +++
Sbjct: 651 NDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE 710
Query: 219 QSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDS 278
++ ++ KE+ RE R E +++ R +++ + + + E + + +
Sbjct: 711 RAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERER 770
Query: 279 MRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKER 334
R E AR +D + + D G+ R + +E+ E++ R+G+++ +
Sbjct: 771 ER-ERERARERDKERERQRDWEDKDKGRDDRRE----KREEIREDRNPRDGHDERK 821
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 42.7 bits (99), Expect = 0.001
Identities = 29/159 (18%), Positives = 74/159 (46%), Gaps = 20/159 (12%)
Query: 206 ENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTD 265
E + +Q+L + QQ +Q+ +++ ++RQ Q++E+++KQ +Q E+
Sbjct: 841 EQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERL-------- 892
Query: 266 SENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKP 325
E + L +++ R + G + E+ + +R + +I E E A +
Sbjct: 893 -EQEHTNRLRDEAKRIK----------GEQEKELSKFQ-NMLKNRKKEVINEVEKAPKEL 940
Query: 326 KREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVV 364
++E + ++ S + + + +QEL+ ++ +++
Sbjct: 941 RKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKII 979
Score = 32.0 bits (71), Expect = 2.1
Identities = 44/232 (18%), Positives = 95/232 (40%), Gaps = 28/232 (12%)
Query: 151 QFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNE------NEREMAPQSVSPRESY 204
Q ++D + ++ ++A + NI R ++ +R E ER + + ++
Sbjct: 968 QQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQL 1027
Query: 205 REN---------KRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQE 255
++ KR +K +Q Q+ Q+L+ K ++ +ER +L + K + +
Sbjct: 1028 KDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFK 1087
Query: 256 KFYQIYDST--DSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCEL---------DP 304
K +I + D + D+ + + + + AQ + +N+M +L +
Sbjct: 1088 KSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQ--KHENQMRDLQLQCEANVREL 1145
Query: 305 GQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQEL 356
Q + L+ E E + K E +++E L+P K L E ++L
Sbjct: 1146 HQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKL 1197
>gi|239752551 PREDICTED: hypothetical protein [Homo sapiens]
Length = 238
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/172 (19%), Positives = 78/172 (45%), Gaps = 25/172 (14%)
Query: 188 ENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQ 247
E E +M Q E + +Q+LP+Q+++ ++Q R++++R +++ QQ+E M+
Sbjct: 51 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKMWEQDERLREKEERMREQKMWQQVEKMR 110
Query: 248 KQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQF 307
++ + +EK + E+ M+ + ++ + + +M E + +
Sbjct: 111 EKKKTQEEKMQE---------------QEEKMQEQ------EEMMWEQEEKMQEQEEKMW 149
Query: 308 IDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTA 359
+ +E++M E + K +G ++ ++P G E Q+ TA
Sbjct: 150 EQEEKMREQEEKMREQEEKMQGQEEKM----RDVEPAGGEAGEGSPQDNPTA 197
Score = 34.3 bits (77), Expect = 0.43
Identities = 26/129 (20%), Positives = 64/129 (49%), Gaps = 7/129 (5%)
Query: 202 ESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIY 261
E RE ++K + ++ + ++ + ++E+ RE+ ++ +Q E MQ+Q ++ E+ +++
Sbjct: 5 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 64
Query: 262 DSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFID--RARALIREQE 319
+ + + E L E + D R ++ + M E Q ++ R + +E++
Sbjct: 65 EQ-EEKMWEQQRLPEQKEKMWEQDERLRE----KEERMREQKMWQQVEKMREKKKTQEEK 119
Query: 320 MAENKPKRE 328
M E + K +
Sbjct: 120 MQEQEEKMQ 128
Score = 33.1 bits (74), Expect = 0.95
Identities = 22/116 (18%), Positives = 56/116 (48%), Gaps = 4/116 (3%)
Query: 222 QQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNL--SEDSM 279
++ + R+++ REE +++Q E MQ+Q +++E+ ++++ + +++ + E+ M
Sbjct: 4 EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 63
Query: 280 RSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERD 335
+ Q + +M E D + + +REQ+M + K K ++
Sbjct: 64 WEQEEKMWEQQRLPEQKEKMWEQD--ERLREKEERMREQKMWQQVEKMREKKKTQE 117
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,252,702
Number of Sequences: 37866
Number of extensions: 1416400
Number of successful extensions: 12086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 600
Number of HSP's that attempted gapping in prelim test: 6954
Number of HSP's gapped (non-prelim): 3410
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.