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Search of human proteins with 21264614
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
(717 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 1419 0.0
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 1370 0.0
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 1370 0.0
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 785 0.0
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 682 0.0
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 428 e-120
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 152 1e-36
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 152 1e-36
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 143 6e-34
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 134 2e-31
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 126 6e-29
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 84 3e-16
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 80 5e-15
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 80 9e-15
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 80 9e-15
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 78 3e-14
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 75 3e-13
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 72 2e-12
gi|239735519 SET binding factor 1 [Homo sapiens] 70 9e-12
gi|29788755 SET binding factor 2 [Homo sapiens] 68 3e-11
gi|209863002 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862998 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862994 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|18860873 MAP-kinase activating death domain-containing protei... 62 2e-09
gi|209862987 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862983 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862979 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862975 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209862971 MAP-kinase activating death domain-containing prote... 62 2e-09
gi|209571517 MAP-kinase activating death domain-containing prote... 62 2e-09
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 1419 bits (3672), Expect = 0.0
Identities = 717/717 (100%), Positives = 717/717 (100%)
Query: 1 MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 60
MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK
Sbjct: 1 MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSK 60
Query: 61 STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 120
STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP
Sbjct: 61 STLEENAYEDIVGDLPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSP 120
Query: 121 PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 180
PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST
Sbjct: 121 PTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLST 180
Query: 181 TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 240
TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR
Sbjct: 181 TSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDR 240
Query: 241 FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 300
FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY
Sbjct: 241 FKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSY 300
Query: 301 QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 360
QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC
Sbjct: 301 QFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYC 360
Query: 361 RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 420
RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA
Sbjct: 361 RRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPA 420
Query: 421 PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 480
PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI
Sbjct: 421 PGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVI 480
Query: 481 FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 540
FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK
Sbjct: 481 FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 540
Query: 541 ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 600
ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN
Sbjct: 541 ELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECN 600
Query: 601 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 660
TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ
Sbjct: 601 TLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQ 660
Query: 661 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 717
MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 661 MFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 717
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 1370 bits (3545), Expect = 0.0
Identities = 693/696 (99%), Positives = 694/696 (99%)
Query: 22 RGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 81
R + SRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY
Sbjct: 442 RKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 501
Query: 82 EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 141
EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER
Sbjct: 502 EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 561
Query: 142 KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 201
KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN
Sbjct: 562 KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 621
Query: 202 SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 261
SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY
Sbjct: 622 SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 681
Query: 262 RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 321
RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA
Sbjct: 682 RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 741
Query: 322 IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 381
IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR
Sbjct: 742 IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 801
Query: 382 LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 441
LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL
Sbjct: 802 LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 861
Query: 442 RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 501
RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY
Sbjct: 862 RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 921
Query: 502 PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 561
PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM
Sbjct: 922 PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 981
Query: 562 DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 621
DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY
Sbjct: 982 DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 1041
Query: 622 SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 681
SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE
Sbjct: 1042 SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 1101
Query: 682 QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 717
QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 1102 QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137
Score = 60.5 bits (145), Expect = 5e-09
Identities = 36/86 (41%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 1 MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFED---ASSLQSLYPSSPTENGTENQPKF 57
MTMTANKNSSITHGAGGTKAPRGTLSR + +YP S +E P
Sbjct: 1 MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60
Query: 58 GSKSTLEENAYEDIVGDLPKENPYED 83
S L ++ + ++P D
Sbjct: 61 SSSRVLLKDRHPPAPSPQNPQDPSPD 86
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 1370 bits (3545), Expect = 0.0
Identities = 693/696 (99%), Positives = 694/696 (99%)
Query: 22 RGTLSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 81
R + SRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY
Sbjct: 442 RKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTLEENAYEDIVGDLPKENPY 501
Query: 82 EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 141
EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER
Sbjct: 502 EDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSER 561
Query: 142 KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 201
KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN
Sbjct: 562 KSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRIN 621
Query: 202 SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 261
SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY
Sbjct: 622 SIYNAKRGKKRLKKLSMSSIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSY 681
Query: 262 RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 321
RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA
Sbjct: 682 RTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKA 741
Query: 322 IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 381
IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR
Sbjct: 742 IPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISR 801
Query: 382 LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 441
LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL
Sbjct: 802 LGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLEL 861
Query: 442 RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 501
RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY
Sbjct: 862 RRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLY 921
Query: 502 PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 561
PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM
Sbjct: 922 PFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQM 981
Query: 562 DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 621
DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY
Sbjct: 982 DDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHY 1041
Query: 622 SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 681
SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE
Sbjct: 1042 SLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFE 1101
Query: 682 QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 717
QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN
Sbjct: 1102 QRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKKN 1137
Score = 60.5 bits (145), Expect = 5e-09
Identities = 36/86 (41%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 1 MTMTANKNSSITHGAGGTKAPRGTLSRKSFEFED---ASSLQSLYPSSPTENGTENQPKF 57
MTMTANKNSSITHGAGGTKAPRGTLSR + +YP S +E P
Sbjct: 1 MTMTANKNSSITHGAGGTKAPRGTLSRSQSVSPPPVLSPPRSPIYPLSDSETSACRYPSH 60
Query: 58 GSKSTLEENAYEDIVGDLPKENPYED 83
S L ++ + ++P D
Sbjct: 61 SSSRVLLKDRHPPAPSPQNPQDPSPD 86
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 785 bits (2026), Expect = 0.0
Identities = 422/697 (60%), Positives = 524/697 (75%), Gaps = 26/697 (3%)
Query: 27 RKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTL-EENAYEDIVGDLPKENPYEDVD 85
RKS+EFED LQS SS + Q K G TL EEN YEDI+ KENPYED++
Sbjct: 332 RKSYEFEDL--LQSSSESSRVD--WYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIE 387
Query: 86 LKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSERKSHR 145
L R G+K L+ SP +S P L+ + S+ SER++ +
Sbjct: 388 LHGRCLGKKCV---------LNFPASPT----SSIPDTLTKQSLSKPAFFRQNSERRNFK 434
Query: 146 LPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRINSIYN 205
L K S D +++S PS+PSS +D + + R+ R+IPKLV RIN+IY
Sbjct: 435 LLDTRKL-SRDGTGSPSKISPPSTPSS-PDDIFFNLGDPQNGRKKRKIPKLVLRINAIYE 492
Query: 206 AKRGKKRLKKLSMS-SIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTL 264
+RGKKR+K+LS S + + DENSES+SD++++ KAH+QRLV+++S LK+AP Y +L
Sbjct: 493 VRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSL 552
Query: 265 ELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFP-KLDRPTKQMREAEERLKAIP 323
EL+E+QER+LFEYFVVVSL KK + Y+PE++ QFP KL+R K MREAE++LKAIP
Sbjct: 553 ARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIP 612
Query: 324 QFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLG 383
QFCFPDAKDW+PV +++SETFSF+LTGEDGSRRFGYCRRLLP GKG RLPEVYC++SRLG
Sbjct: 613 QFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLG 672
Query: 384 CFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRR 443
CF LFS++LDEVE+RRGIS ALV P MRS+ME+PFPA GKTI VK FLPG+G EV+EL R
Sbjct: 673 CFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCR 732
Query: 444 PMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPF 503
P+DSRLEHVDFE LF+ LSVR L+ +FASLLLERRVIF+ADKLS LS C HA+VAL+YPF
Sbjct: 733 PLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPF 792
Query: 504 SWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDD 563
+WQHT+IPVLP +M+DIVC PTPFL+GLLSSSLP L+ELP+EE L+V+L + RF+RQMDD
Sbjct: 793 AWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDD 852
Query: 564 EDTLLPRKLQAALEQALERKNELISQDSDSDSD----DECNTLNGLVSEVFIRFFVETVG 619
ED++LPRKLQ ALE LE++NEL + + D E + LN +VSE F+RFFVE VG
Sbjct: 853 EDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVG 912
Query: 620 HYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL 679
HYSLFLT E+ ER QREAFRK+V+SKS+R FLEVFME+QMF GFIQ+RELR+ AKGL
Sbjct: 913 HYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGL 972
Query: 680 FEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKK 716
FE R ++YLE LP E SG+NKFL+GLGNKMKFLHKK
Sbjct: 973 FEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 682 bits (1760), Expect = 0.0
Identities = 355/603 (58%), Positives = 451/603 (74%), Gaps = 13/603 (2%)
Query: 115 RKYNSPPTQLSLKPNSQSLRSGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLN 174
R NS + L NS S SE + P + + + + + L + SPS+
Sbjct: 281 RNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAW- 339
Query: 175 EDSLSTTSELLSSRRARRIPKLVQRINSIYNAKRGKKRLKKLSMSSIETASLRDENSESE 234
+L ++ A + PKLV +I+ I+ +KRGKK++K S + E + E S +E
Sbjct: 340 --------KLPPAKSAFKAPKLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNE 391
Query: 235 SDSDDRFKAHTQRLVHIQSMLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTY 294
SD++ K +RL +Q KR P Y+TLE +L+E QE++LFE FVVVSL+KKPS +Y
Sbjct: 392 SDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISY 451
Query: 295 LPEVSYQFP-KLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDG 353
+P+V QFP K D KQ ++ EERLK IP+FCFPD+KDW+P SE SETFSF+LTGEDG
Sbjct: 452 IPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDG 511
Query: 354 SRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL 413
SR FGYC++LLP GKG RLPEVYC++SRLGCF LFSK+LDEVE+RR +S ALVYPFMRS+
Sbjct: 512 SRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSV 571
Query: 414 MESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASL 473
ME+PFPAPG+TI VK++LPGAG+E +EL RP+DSRLEHVDF+CLF CLSV LIR+ ASL
Sbjct: 572 MEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASL 631
Query: 474 LLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLS 533
LLERRVIFVA+ LSTLS C HAVVA LYPF+WQHT+IPVLPASMIDIVC PTPFL+G+LS
Sbjct: 632 LLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 691
Query: 534 SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDS 593
SLP+L++LP+EE L+V+L +D+F++++ DED +LP KLQAAL Q LE +NE+++Q+ +
Sbjct: 692 CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNF 751
Query: 594 DSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFL 653
D TLN LVSE F+RFFVE VGHYSL +T +E+GER FQRE FRKS S+S+R FL
Sbjct: 752 SQD---VTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFL 808
Query: 654 EVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFL 713
++FME+QMFAGFIQDRELRK KGLFE R QYLE +P++E SGMN+ LR LG+KMKFL
Sbjct: 809 DLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFL 868
Query: 714 HKK 716
KK
Sbjct: 869 QKK 871
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 428 bits (1101), Expect = e-120
Identities = 211/419 (50%), Positives = 294/419 (70%), Gaps = 12/419 (2%)
Query: 274 RELFEYFVVVSLKKKPSRNTYLPEVSYQFPKLDRPTKQMREAEERL-KAIPQFCFPDAKD 332
+ FEY +VVSLKKK S + Y P ++YQFPK + + +E EERL KAIP FCFPD +
Sbjct: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE 110
Query: 333 WLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVL 392
W ++EY ETFSF+LT DGSR+ GYCRRLLP+G GPRLP+VYC+IS +GCFGLFSK+L
Sbjct: 111 WASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKIL 170
Query: 393 DEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHV 452
DEVE+R IS A++YPFM+ L E+ FPAPGKT+ +K+F+P +G E + L RP+DS LEHV
Sbjct: 171 DEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHV 230
Query: 453 DFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPV 512
DF L CLS Q+++IFAS +LER++IF+A+ LSTLS C HA ALLYPFSW HT+IPV
Sbjct: 231 DFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPV 290
Query: 513 LPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 572
+P S++ VCCPTPF+VG+ ++ + P+EE L+VNL F+ + DE +LP KL
Sbjct: 291 VPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPKL 350
Query: 573 QAALEQAL-ERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKG 631
Q + +L + NEL + + +N VS F++FFV+ VGHY+ ++ + G
Sbjct: 351 QDDILDSLGQGINELKTAEQ----------INEHVSGPFVQFFVKIVGHYASYIKREANG 400
Query: 632 ERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQRVEQYLEE 690
+ FQ +F K++ SK+ RRF++ F+++Q+F+ FIQ+ E K G F+Q++ +Y E+
Sbjct: 401 QGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILEYEEQ 459
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 152 bits (383), Expect = 1e-36
Identities = 107/379 (28%), Positives = 185/379 (48%), Gaps = 43/379 (11%)
Query: 296 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 355
PEV QFP + +E L+ + +FCFP D L VS+ + F+F+LT D +
Sbjct: 31 PEVQRQFP-------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDSKQ 82
Query: 356 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLD-----EVERRRGISAALVYPFM 410
RFG+CR L SG +C++S L F +F K+L+ +R+ L +
Sbjct: 83 RFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL----L 132
Query: 411 RSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIF 470
+L + P P PG ++ + + EL ++R + F + V ++ ++
Sbjct: 133 ETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENR----NLTEYFVAVDVNNMLHLY 188
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530
AS+L ERR++ + KLSTL++C H A+LYP WQH +IPVLP ++D C P P+L+G
Sbjct: 189 ASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIG 248
Query: 531 LLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQD 590
+ S + K++ + +++ +++N+ ++ DD + LP + ++L+ L++ +
Sbjct: 249 IHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQS-LPNDVISSLKNRLKKVS------ 301
Query: 591 SDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIR 650
T V+ F++ G Y L + F EAF S ++R
Sbjct: 302 ---------TTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMR 352
Query: 651 RFLEVFMESQMFAGFIQDR 669
+FL+ + Q+F FI R
Sbjct: 353 QFLQNATQLQLFKQFIDGR 371
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 152 bits (383), Expect = 1e-36
Identities = 107/379 (28%), Positives = 185/379 (48%), Gaps = 43/379 (11%)
Query: 296 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 355
PEV QFP + +E L+ + +FCFP D L VS+ + F+F+LT D +
Sbjct: 31 PEVQRQFP-------EDYSDQEVLQTLTKFCFPFYVDSLTVSQVG-QNFTFVLTDIDSKQ 82
Query: 356 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLD-----EVERRRGISAALVYPFM 410
RFG+CR L SG +C++S L F +F K+L+ +R+ L +
Sbjct: 83 RFGFCR--LSSGA----KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNEL----L 132
Query: 411 RSLMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIF 470
+L + P P PG ++ + + EL ++R + F + V ++ ++
Sbjct: 133 ETLHKLPIPDPGVSVHLSVHSYFTVPDTRELPSIPENR----NLTEYFVAVDVNNMLHLY 188
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530
AS+L ERR++ + KLSTL++C H A+LYP WQH +IPVLP ++D C P P+L+G
Sbjct: 189 ASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIG 248
Query: 531 LLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQD 590
+ S + K++ + +++ +++N+ ++ DD + LP + ++L+ L++ +
Sbjct: 249 IHLSLMEKVRNMALDDVVILNVDTNTLETPFDDLQS-LPNDVISSLKNRLKKVS------ 301
Query: 591 SDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIR 650
T V+ F++ G Y L + F EAF S ++R
Sbjct: 302 ---------TTTGDGVARAFLKAQAAFFGSYRNALKIEPEEPITFCEEAFVSHYRSGAMR 352
Query: 651 RFLEVFMESQMFAGFIQDR 669
+FL+ + Q+F FI R
Sbjct: 353 QFLQNATQLQLFKQFIDGR 371
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 143 bits (360), Expect = 6e-34
Identities = 105/378 (27%), Positives = 183/378 (48%), Gaps = 42/378 (11%)
Query: 316 EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 375
+E L+++P+FCFP + + ++ F+F+LT + +RFG+CR L SG L
Sbjct: 42 QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95
Query: 376 YCVISRLGCFGLFSKVLDEV------ERRRGISAALVYPFMRSLMESPFPAPGKTIKVKT 429
C++S L F ++ K+L+ + E ++ L RSL P P + +
Sbjct: 96 -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETL-----RSLYNHPVPKANTPVNLSV 149
Query: 430 FLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTL 489
+V L +SR + F + V +++++AS+L ERR++ ++ KLSTL
Sbjct: 150 HSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 205
Query: 490 SSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALM 549
++C H ALLYP WQH +IPVLP ++D C P P+L+G+ SS + ++K +E+ +M
Sbjct: 206 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 265
Query: 550 VNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDECNTLNGLVSEV 609
+N+ ++ D + LP + +AL+ L++++ V+
Sbjct: 266 LNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG---------------VARA 309
Query: 610 FIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDR 669
F+R G Y L F E+F K S +++FLE + Q+F FI R
Sbjct: 310 FLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGR 368
Query: 670 ELRKCRAKG---LFEQRV 684
+ +G +FE+ +
Sbjct: 369 LAKLNAGRGFSDVFEEEI 386
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 134 bits (338), Expect = 2e-31
Identities = 104/389 (26%), Positives = 186/389 (47%), Gaps = 44/389 (11%)
Query: 316 EERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEV 375
+E L+++P+FCFP + + ++ F+F+LT + +RFG+CR L SG L
Sbjct: 42 QEILQSVPKFCFPFDVERVSQNQVGQH-FTFVLTDIESKQRFGFCR--LTSGGTICL--- 95
Query: 376 YCVISRLGCFGLFSKVLD--------EVERRRGISAALVY---------PFMRSLMESPF 418
C++S L F ++ K+L+ E+E + +Y P S+ + F
Sbjct: 96 -CILSYLPWFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIF 154
Query: 419 PAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERR 478
A + +K + L + + + E + F + V +++++AS+L ERR
Sbjct: 155 IACEQVLKDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERR 214
Query: 479 VIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPK 538
++ ++ KLSTL++C H ALLYP WQH +IPVLP ++D C P P+L+G+ SS + +
Sbjct: 215 IVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIER 274
Query: 539 LKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSDDE 598
+K +E+ +M+N+ ++ D + LP + +AL+ L++++
Sbjct: 275 VKNKSLEDVVMLNVDTNTLESPFSDLNN-LPSDVVSALKNKLKKQSTATGDG-------- 325
Query: 599 CNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFME 658
V+ F+R G Y L F E+F K S +++FLE +
Sbjct: 326 -------VARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKH-RSSVMKQFLETAIN 377
Query: 659 SQMFAGFIQDRELRKCRAKG---LFEQRV 684
Q+F FI R + +G +FE+ +
Sbjct: 378 LQLFKQFIDGRLAKLNAGRGFSDVFEEEI 406
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 126 bits (317), Expect = 6e-29
Identities = 110/406 (27%), Positives = 181/406 (44%), Gaps = 49/406 (12%)
Query: 296 PEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSR 355
P + QFP R +E ++ +P+FCFP + P S + + F+F LT G+R
Sbjct: 29 PPILRQFPPDFRD-------QEAMQMVPKFCFPFDVEREPPSP-AVQHFTFALTDLAGNR 80
Query: 356 RFGYCRRLLPSGKGPRLPEVYCVISRLGCFGLFSKVLDEV-ERRRGISAALVYPFMRSLM 414
RFG+CR L +G L C++S L F +F K+L+ V + +++L
Sbjct: 81 RFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 134
Query: 415 ESPFPAP----------GKTIKVKTFLP----GAGNEVLELRRPMDSRL----EHVDFEC 456
+ P G T+ +P G + P RL E+ +
Sbjct: 135 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 194
Query: 457 LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPAS 516
L ++ ++ +FA+LL ERRV+ A KLSTL+SC HA ALLYP W+H IP LP
Sbjct: 195 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 254
Query: 517 MIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAAL 576
++D C P P+L+G+ +S +++E +E+ +++N+ ++ +D L P + +L
Sbjct: 255 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVV--SL 312
Query: 577 EQALERKNELISQDSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQ 636
+ RK L + VS +F++ G Y L S F
Sbjct: 313 LRLRLRKVALAPGEG--------------VSRLFLKAQALLFGGYRDALVCSPGQPVTFS 358
Query: 637 REAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQ 682
E F ++ F + Q+F FI+ R + + +G +Q
Sbjct: 359 EEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQ 404
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 84.3 bits (207), Expect = 3e-16
Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 8/168 (4%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 470
L E P P PG+++K G ++ +RP + L DF +F L V + ++F
Sbjct: 248 LYEVPLPPPGRSLKFS----GVYGPII-CQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530
LLE +++ + L + + + AL++PF WQH ++P+LPAS++ + P P+L+G
Sbjct: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
Query: 531 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE 577
L S+ L +L + +EA + + D ++ ++ P KL+ E
Sbjct: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQE 410
Score = 35.4 bits (80), Expect = 0.19
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)
Query: 568 LPRKLQAALEQALERKNELISQDSDSDSDDE---CNTLNGLVSEVFIRFFVETVGHYSLF 624
L ++ +LE+ R++ ++D D+E LN + EVF F + Y +F
Sbjct: 475 LVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVF 534
Query: 625 LTQSEKGERAF-----QREAFRK----SVASKSIRRFLEVFMESQMFAGFIQDR 669
+ Q + + ++ Q + F K S + FL F+E+QMFA FI ++
Sbjct: 535 VIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNK 588
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 80.5 bits (197), Expect = 5e-15
Identities = 50/165 (30%), Positives = 85/165 (51%), Gaps = 12/165 (7%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 470
L E P P PG+++K E + +RP S L D+ F L + L+++F
Sbjct: 233 LYEVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530
+LLE +++ + L + + + LL+PF WQH ++P+LPAS++ + P P+L+G
Sbjct: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
Query: 531 LLS---SSLPKLKELPVEEALMVNLGSDRFIRQMDDEDTLLPRKL 572
L S + KL ELP +EA + + D ++ +E P K+
Sbjct: 348 LQSKEGTDRSKL-ELP-QEANLCFVDIDNHFIELPEEFPQFPNKV 390
Score = 31.2 bits (69), Expect = 3.5
Identities = 26/98 (26%), Positives = 46/98 (46%), Gaps = 13/98 (13%)
Query: 602 LNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAF-----QREAFRK----SVASKSIRRF 652
LN + EVF F + Y F+ Q+ + ++ Q + F K S + F
Sbjct: 498 LNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQPEPYLPF 557
Query: 653 LEVFMESQMFAGFIQDRELRKCRAKG----LFEQRVEQ 686
L F+E+QMFA FI ++ + + K +F+ R+++
Sbjct: 558 LSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDK 595
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 79.7 bits (195), Expect = 9e-15
Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)
Query: 298 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 353
VSY+ + R ++ E+ +++P FC P + W S+Y FS F+LTG
Sbjct: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
Query: 354 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 388
+ +G +RLL S K + C++S F F
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
Query: 389 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 444
K L + R IS V P + + + PFP+P + + P ++ L L +P
Sbjct: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
Query: 445 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 502
+ S L F L L + + + E +++ + + S L+S + A+V++++P
Sbjct: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
Query: 503 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 562
F W ++P+ P ++ D++ P PF+VG+ S P + V+ + I Q+
Sbjct: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
Query: 563 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 602
D+ +LP+K L L + +R +L D D +S + +
Sbjct: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
Query: 603 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 654
+ + E F+ F + Y +L SE A F +AF +S +S ++F
Sbjct: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
Query: 655 VFMESQMFAGFIQD 668
+ ++QMF FI++
Sbjct: 618 MMTKTQMFIRFIEE 631
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 79.7 bits (195), Expect = 9e-15
Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)
Query: 298 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 353
VSY+ + R ++ E+ +++P FC P + W S+Y FS F+LTG
Sbjct: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
Query: 354 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 388
+ +G +RLL S K + C++S F F
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
Query: 389 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 444
K L + R IS V P + + + PFP+P + + P ++ L L +P
Sbjct: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
Query: 445 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 502
+ S L F L L + + + E +++ + + S L+S + A+V++++P
Sbjct: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
Query: 503 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 562
F W ++P+ P ++ D++ P PF+VG+ S P + V+ + I Q+
Sbjct: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
Query: 563 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 602
D+ +LP+K L L + +R +L D D +S + +
Sbjct: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
Query: 603 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 654
+ + E F+ F + Y +L SE A F +AF +S +S ++F
Sbjct: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
Query: 655 VFMESQMFAGFIQD 668
+ ++QMF FI++
Sbjct: 618 MMTKTQMFIRFIEE 631
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 77.8 bits (190), Expect = 3e-14
Identities = 96/396 (24%), Positives = 157/396 (39%), Gaps = 48/396 (12%)
Query: 319 LKAIPQFCFPDAKDWLPVSEYSSETFSFM-LTGEDGSRRFG----YCRRL-----LPSGK 368
L +PQ CFP +E + F+ LT G+R +G Y R L +GK
Sbjct: 39 LLTLPQLCFPGGV--CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGK 96
Query: 369 GPR------LPEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLME 415
R +P CV+SR C +L + S + SL+
Sbjct: 97 THRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIP 156
Query: 416 SPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLL 475
SP P P + F + VL R +S + +D C ++++I +L
Sbjct: 157 SPPPGPLHLV----FNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 212
Query: 476 ERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSS 535
E+R++F + + L+ + +A LYP WQH F+P+L M+D V PT FL+G
Sbjct: 213 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH 272
Query: 536 LPKL-KELPVEEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE-----QALERKNELISQ 589
++ KE + ++ GS + + DD + L AA Q+L+ +EL +
Sbjct: 273 FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA 332
Query: 590 DSDSDSD---------DECNTLNGLVSEVFIRFFVETVGHYSLFLTQSEKGERAFQREAF 640
S +D LN + + ++ V L R F E F
Sbjct: 333 HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYE---HRVFNSEEF 389
Query: 641 RKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRA 676
K+ A +F + +++ MF F++ R R+ A
Sbjct: 390 LKTRAPGD-HQFYKQVLDTYMFHSFLKARLNRRMDA 424
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 74.7 bits (182), Expect = 3e-13
Identities = 88/416 (21%), Positives = 172/416 (41%), Gaps = 70/416 (16%)
Query: 333 WLPVSEYSSETFS-FMLTGEDGSRRFG--------YCRRLLPS----------------- 366
W P ++Y FS F+LTG + +G Y R LL
Sbjct: 8 WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
Query: 367 GKGPRLPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSL----MESPFPAPG 422
K + C++S F F K L + + +S P + + PFP+P
Sbjct: 68 SKSINTNKCICLLSHWPFFEAFRKFLMFIYKL-SVSGPHPLPIEKHISHFMQNIPFPSPQ 126
Query: 423 KTIKVKTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVI 480
+ + + + ++ L L +P+ + L +F L L + +LLE +++
Sbjct: 127 RP---RILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKIL 183
Query: 481 FVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLK 540
+ + + L+ + AVVA+++PF WQ +IP+ P S+ ++ P PF+VG + S L
Sbjct: 184 LHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVG-VDSRYFDLH 242
Query: 541 ELPVEEALMVNLGSDRFIRQMDDEDTL----LPRKLQAALEQALERKNELISQ------- 589
+ P ++ + ++L ++ + D++ + LP+K L L++ +S
Sbjct: 243 D-PPQDVVCIDLDTN-MLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
Query: 590 ---------DSDSDSDDECNTLNGLVSEVFIRFFVETVGHYSLFL--------TQSEKGE 632
++D + L + E F+RF + Y +L ++ +
Sbjct: 301 GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
Query: 633 RAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 686
F R+ F KS ++ +F + ++Q+F FI++ + GL F+ +E+
Sbjct: 361 SLFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEK 415
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 71.6 bits (174), Expect = 2e-12
Identities = 105/455 (23%), Positives = 184/455 (40%), Gaps = 78/455 (17%)
Query: 300 YQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDGSR 355
Y+ L R ++ EA +++P FC P + W ++Y FS F+LTG G +
Sbjct: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
Query: 356 RFGYCRRLLPS---------------------------GKGPRLPEVYCVISRLGCFGLF 388
+G + + G+ R V+SR F F
Sbjct: 271 VYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAF 330
Query: 389 SKVLDEVER------RRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELR 442
L + R R A + F+ ++ PFP+P + + P + L L
Sbjct: 331 RAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSP---YDNLLLC 384
Query: 443 RPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 500
+P+ S L F L L I + ++L E +++ + + L+S A+V+++
Sbjct: 385 QPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 444
Query: 501 YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQ 560
+P WQ +IP+ P + D++ P PF+VG+ SS P + + V+L ++ Q
Sbjct: 445 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLDTNTLF-Q 501
Query: 561 MDDEDTLLPRKLQ--------AALEQALERKNELISQDSD--------SDSDDECNTLNG 604
+++ L PR L A L ++ ++ + + +D + C
Sbjct: 502 TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRAR 561
Query: 605 LVSEV---FIRFFVETVGHYSLF---LTQS-EKGER----AFQREAFRKSVASKSIRRFL 653
L EV F+RF + Y +F LTQ+ +G R F + F KS +S +
Sbjct: 562 LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-RERSSHKLY 620
Query: 654 EVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 686
+ +QMF+ FI++ R L F+ VE+
Sbjct: 621 SQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEK 655
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 69.7 bits (169), Expect = 9e-12
Identities = 69/305 (22%), Positives = 134/305 (43%), Gaps = 37/305 (12%)
Query: 428 KTFLPGAGNEVLELRRPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADK 485
+T GAG+ + ++ P+ L LF L + ++ +F + L E +V+F++
Sbjct: 184 RTISLGAGDRQV-IQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRS 242
Query: 486 LSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVE 545
L+ ++ALL+P + T++P+LPA +++++ PTPF++G+ ++ + +EL
Sbjct: 243 YQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQEL--L 300
Query: 546 EALMVNLGSDRFIRQMDDEDTLLPRKLQ----AALEQALERKNEL--ISQDSDSDSDDEC 599
+ ++ +L LP LQ + L L+ + EL ++ + S
Sbjct: 301 DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360
Query: 600 NTLNGLVSEVFIRFFVETVGHYSLFL----TQSEKGERAFQREAF--RKSVASKSIRRFL 653
+ + VF+R F + + Y L E R F + AF ++ + FL
Sbjct: 361 KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIR-FHKAAFLGQRGLVEDD---FL 416
Query: 654 EVFMESQMFAGFIQDR----------------ELRKCRAKGLFEQRVEQYLEELPDTEQS 697
+E FAGF+ +R E+ + RA QRV ++++EL +
Sbjct: 417 MKVLEGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYK 476
Query: 698 GMNKF 702
N +
Sbjct: 477 NENPY 481
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 67.8 bits (164), Expect = 3e-11
Identities = 112/494 (22%), Positives = 190/494 (38%), Gaps = 94/494 (19%)
Query: 276 LFEYFVVVSLK-KKPSRNTYLPEVSYQFPKLDRPTKQMREAEERLKAIPQFCFPDAKDWL 334
L +YF+VV +KP L ++ +FP+ D + I FC P W
Sbjct: 4 LADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQG------IELFCQPGG--WQ 55
Query: 335 PVSEYSSETFSFM-LTGEDGSRRFGYCRRL------LPSGKGPRL--------------- 372
E TF + LT D R + C L K +
Sbjct: 56 LSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEV 115
Query: 373 --PEVYCVISRL-------GCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGK 423
P+ ++SRL C GL V + ++ +L + +L PA G
Sbjct: 116 FAPKSLVLVSRLYYPEIFRACLGLIYTVYVD-----SLNVSLE-SLIANLCACLVPAAGG 169
Query: 424 TIKVKTFLPGAGNEVLELRRPMDSRLE--HVDFECLFTCLSVRQLIRIFASLLLERRVIF 481
+ K+ F GAG+ L ++ P+ L LF L ++ ++ +F ++L E +V+F
Sbjct: 170 SQKL--FSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLF 226
Query: 482 VADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKE 541
+ LS A+ +L++P + + +IP+LPA +++++ PTPF++G+ S + E
Sbjct: 227 HSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE 286
Query: 542 LPVEEALMVNLGSDRFIRQMDDEDTLLPR--KLQAALEQALERKNELISQDSDSDSD--- 596
L D I +D +P L + E L + +S D +
Sbjct: 287 L-----------LDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVAD 335
Query: 597 ----------DECNTLNGLVSEVFIRFFVETVGHY----SLFLTQSEKGERAFQREAF-- 640
L+ V VF+R F + Y L +E F + AF
Sbjct: 336 HAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIH-FHKTAFLG 394
Query: 641 RKSVASKSIRRFLEVFMESQMFAGFIQDR--ELRKCRAKGLFEQRVEQYLEELPDTEQS- 697
++ + FL + FAGF+ +R R C LF++ V +E + E +
Sbjct: 395 QRGLVEND---FLTKVLSGMAFAGFVSERGPPYRSC---DLFDELVAFEVERIKVEENNP 448
Query: 698 -GMNKFLRGLGNKM 710
M K +R L ++
Sbjct: 449 VKMIKHVRELAEQL 462
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 61.6 bits (148), Expect = 2e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,057,010
Number of Sequences: 37866
Number of extensions: 1252263
Number of successful extensions: 4448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 4292
Number of HSP's gapped (non-prelim): 179
length of query: 717
length of database: 18,247,518
effective HSP length: 110
effective length of query: 607
effective length of database: 14,082,258
effective search space: 8547930606
effective search space used: 8547930606
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.