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Search of human proteins with 21071016
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21071016 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform b [Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21071016 epidermal growth factor receptor pathway substrate 8... 1207 0.0
gi|21071018 epidermal growth factor receptor pathway substrate 8... 1203 0.0
gi|21071014 epidermal growth factor receptor pathway substrate 8... 1125 0.0
gi|21264616 epidermal growth factor receptor pathway substrate 8... 268 8e-72
gi|56682953 epidermal growth factor receptor pathway substrate 8... 260 3e-69
gi|148539853 epidermal growth factor receptor pathway substrate ... 250 2e-66
gi|148539855 epidermal growth factor receptor pathway substrate ... 176 4e-44
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 53 7e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 53 7e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 53 7e-07
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 51 3e-06
gi|20149528 proline-serine-threonine phosphatase interacting pro... 49 1e-05
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 49 1e-05
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 48 3e-05
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 45 1e-04
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 45 1e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 45 2e-04
gi|39930351 dynamin binding protein [Homo sapiens] 45 2e-04
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 45 2e-04
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 45 2e-04
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 45 2e-04
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 45 2e-04
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 44 3e-04
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 44 3e-04
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 44 3e-04
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 44 3e-04
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 44 4e-04
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 44 5e-04
gi|148596974 TXK tyrosine kinase [Homo sapiens] 44 5e-04
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 43 7e-04
>gi|21071016 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform b [Homo sapiens]
Length = 593
Score = 1207 bits (3124), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
Query: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE
Sbjct: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
Query: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR
Sbjct: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
Query: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN
Sbjct: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
Query: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS 420
LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS
Sbjct: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS 420
Query: 421 TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL
Sbjct: 421 TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
Query: 481 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 540
DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA
Sbjct: 481 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 540
Query: 541 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 593
ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Sbjct: 541 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 593
>gi|21071018 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform a [Homo sapiens]
Length = 594
Score = 1203 bits (3112), Expect = 0.0
Identities = 593/594 (99%), Positives = 593/594 (99%), Gaps = 1/594 (0%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQ-RPRLGGLQPGQDRWRGPAMERPLPME 179
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQ RPRLGGLQPGQDRWRGPAMERPLPME
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQSRPRLGGLQPGQDRWRGPAMERPLPME 180
Query: 180 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE 239
QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE
Sbjct: 181 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDE 240
Query: 240 EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG 299
EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG
Sbjct: 241 EVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLG 300
Query: 300 RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES 359
RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES
Sbjct: 301 RLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPES 360
Query: 360 NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLG 419
NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLG
Sbjct: 361 NLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLG 420
Query: 420 STSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV 479
STSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV
Sbjct: 421 STSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEV 480
Query: 480 LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ 539
LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ
Sbjct: 481 LDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQ 540
Query: 540 AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 593
AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Sbjct: 541 AENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 594
>gi|21071014 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform c [Homo sapiens]
Length = 563
Score = 1125 bits (2910), Expect = 0.0
Identities = 563/593 (94%), Positives = 563/593 (94%), Gaps = 30/593 (5%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQ 60
Query: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG
Sbjct: 61 GRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPG 120
Query: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ
Sbjct: 121 LPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQ 180
Query: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE
Sbjct: 181 ARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEE 240
Query: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR
Sbjct: 241 VLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGR 300
Query: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN
Sbjct: 301 LATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESN 360
Query: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGS 420
LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL
Sbjct: 361 LWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSL--------- 411
Query: 421 TSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL
Sbjct: 412 ---------------------RPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 450
Query: 481 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 540
DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA
Sbjct: 451 DHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQA 510
Query: 541 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 593
ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
Sbjct: 511 ENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP 563
>gi|21264616 epidermal growth factor receptor pathway substrate
8-like protein 2 [Homo sapiens]
Length = 715
Score = 268 bits (686), Expect = 8e-72
Identities = 210/686 (30%), Positives = 325/686 (47%), Gaps = 118/686 (17%)
Query: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
+++ S + ++ RK+YS + Q+ V+HL T S+ + +DA++KL ++ +
Sbjct: 24 VAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
Query: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
+ ++W+Q+++LQV D L+LLDIE++EEL+ + L ++Q LN Y S+L + Q+
Sbjct: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
Query: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEE-ELEQRPRLGGLQPGQDRWRGPAMERPLPM 178
F C EV AE + ++ AL + L ++ R L+ Q++ R
Sbjct: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIR---------- 193
Query: 179 EQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDP--- 235
Q + + P PP+ P +H SP R + P + P RR S E+P
Sbjct: 194 -QRQSILP--PPQGPAPIPFQHRGGDSPEAKNR-VGPQVP--LSEPGFRRRESQEEPRAV 247
Query: 236 -----ERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT---- 280
E++ ++LN L DIE F+ +L+KA + + KK GKK +G LT
Sbjct: 248 LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRAR 307
Query: 281 ---QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQV 337
+ ++IDCFQKIK + NLL +L ++ SA ELVH LF L+ I+ C +A V
Sbjct: 308 PPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSV 367
Query: 338 ISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLP- 395
PLL+ A++ L+ L P E +LW LG +W R++W + +P Y P F W+ P
Sbjct: 368 SCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV 427
Query: 396 ----------EPSSQAPLGYQDPVSLRRGSHRLGSTSHFP-QEKTHNHDPQPGDPNSRPS 444
E + AP+ PVS R S R S H P E T D P P S P
Sbjct: 428 DVLQEAPWEVEGLASAPIEEVSPVS--RQSIR-NSQKHSPTSEPTPPGDALP--PVSSPH 482
Query: 445 SPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIP 500
+ + QP A +++LY+F ARN EL+V++ E LEVL+ ++WW +++ +G++GY+P
Sbjct: 483 THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVP 542
Query: 501 SNIL--------------------------EPLQPGTPG--------------------- 513
NIL L P PG
Sbjct: 543 CNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKIS 602
Query: 514 ---TQGQSPSRVPMLRLSSRP-------EEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 563
Q Q RV + S+P +EV WL+A+ FS V LG LTG QL +
Sbjct: 603 NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN 662
Query: 564 PGELQMLCPQEAPRILSRLEAVRRML 589
EL+ +C +E R+ S+L + L
Sbjct: 663 KEELKKVCGEEGVRVYSQLTMQKAFL 688
>gi|56682953 epidermal growth factor receptor pathway substrate 8
[Homo sapiens]
Length = 822
Score = 260 bits (664), Expect = 3e-69
Identities = 181/591 (30%), Positives = 280/591 (47%), Gaps = 100/591 (16%)
Query: 2 SRPSSRAIYLHRKEYSQN-LTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
S+ S++A+Y RK Y+++ ++S + Q+RVEHL T + +D ++KL +DA
Sbjct: 37 SKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDA 96
Query: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
+G+VW+QD+ILQV D + L+D+E+K EL+++ L++IQ +++CSY+S+L++ +EP
Sbjct: 97 KGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEP 156
Query: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPME 179
LFQC EV A + ++ A+ + GG Q RP +
Sbjct: 157 TQNKPDLHLFQCDEVKANLISEDIESAISDSK------GGKQK----------RRPDALR 200
Query: 180 QARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHT-------------SAREPSAFTLPPP 226
+P IPP P +P P P T SA P
Sbjct: 201 MISNADPSIPPP-----------PRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKP 249
Query: 227 RRSSSPEDP--------ERDEEVLNHVLRDIELFMGKLEKAQ------AKTSRKKKFGKK 272
R+ E+ +RD ++LNH+L DIE F+ KL+KA +K + KK +K
Sbjct: 250 RQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRK 309
Query: 273 NKDQGGLTQA-------QYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFIL 325
+G LT +++DCFQK KH FNLL +L + ++ SA +LVH LF LN ++
Sbjct: 310 GPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVV 369
Query: 326 ARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPL-PY 384
LA+ V+SPLL I+ L ++ E LWM LG W +RA+W ++ + PY
Sbjct: 370 QATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPY 429
Query: 385 QPTFSDDWQLPEPSSQAPLGYQDPVSL-----------RRGSHRLGSTSHFPQEKTHNHD 433
P F + W+ P + QD L R+ + ST H + H D
Sbjct: 430 VPRFRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPAD 489
Query: 434 -------------------------PQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRE 468
P R P QP + Y+F ARN E
Sbjct: 490 GYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDFVARNNSE 549
Query: 469 LTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSP 519
L+V++ + LE+LD K+WW V+N +G SG++P+NIL+ ++P G P
Sbjct: 550 LSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADP 600
Score = 51.6 bits (122), Expect = 2e-06
Identities = 45/183 (24%), Positives = 82/183 (44%), Gaps = 16/183 (8%)
Query: 422 SHFPQEKTHNHDPQPGDPNSRPSSPK-------PAQPALKMQV-LYEFEARNPRELTVVQ 473
+H Q++ + P+P D PS P P P+ V + + A R+ +
Sbjct: 603 THTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSS 662
Query: 474 GEKLEVLDHSKRWWLVKNEAGRSGY--IPSNILEPLQPGTPGTQGQ---SPSRVPMLRLS 528
++ S+R + + +S + ++ L G Q + VP++ ++
Sbjct: 663 DSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINIT 722
Query: 529 --SRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVR 586
S PE+V WLQ++ F+ TV +LG L G+QL + EL+ +CP E R+ S++ +
Sbjct: 723 YDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCP-EGARVYSQITVQK 781
Query: 587 RML 589
L
Sbjct: 782 AAL 784
>gi|148539853 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform a [Homo sapiens]
Length = 723
Score = 250 bits (639), Expect = 2e-66
Identities = 184/555 (33%), Positives = 285/555 (51%), Gaps = 54/555 (9%)
Query: 3 RPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDAQG 61
+PS+++IY RK YS + ++ + Q+ V HL+T C V EDA +KL MD+QG
Sbjct: 12 KPSAKSIYEQRKRYSTVVMADVS--QYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQG 69
Query: 62 RVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGL 121
RVW+Q+++L+V + LLD +KEEL+SY L +I + + S+L + QEP
Sbjct: 70 RVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPER 129
Query: 122 PGTSTLLFQCQEVGAERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPL 176
FQ +GAE ++ +Q AL R R L+ Q+ R R PA E P
Sbjct: 130 AQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP- 188
Query: 177 PMEQARYLEPGIPPEQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE 233
P+++ P + T+E P +P+P A+ P S+SP+
Sbjct: 189 PLQRR-------PSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPD 241
Query: 234 -----------DPERDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQ 276
ER+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +
Sbjct: 242 LGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGE 301
Query: 277 GGLT-------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP 329
G LT +A+Y D QKIK++F+LL RL + + S+PEL+H LF L I+
Sbjct: 302 GLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSG 361
Query: 330 EAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFS 389
A+ V P LT A+ LL+ ++P E+ LW LG +WT + + +E PY+P F
Sbjct: 362 GPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFF 421
Query: 390 DDWQLP--EPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPK 447
W+ P +P S+A ++DPV + R PQ + H + +P S P
Sbjct: 422 SGWEPPVTDPQSRA---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--L 474
Query: 448 PAQPALKMQVL-YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEP 506
++ A K + Y+F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P
Sbjct: 475 ESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP 534
Query: 507 LQPGTPGTQGQSPSR 521
PG QSP+R
Sbjct: 535 -YPGPRLHHSQSPAR 548
Score = 56.2 bits (134), Expect = 8e-08
Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)
Query: 424 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
+P + H+ NS P +P PA P + ++ PR + + L L
Sbjct: 535 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 587
Query: 481 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 529
D S++ L+ NE GRSG PS + PG + P P S
Sbjct: 588 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 634
Query: 530 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 589
EV WLQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 635 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 694
>gi|148539855 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform b [Homo sapiens]
Length = 596
Score = 176 bits (447), Expect = 4e-44
Identities = 135/421 (32%), Positives = 210/421 (49%), Gaps = 51/421 (12%)
Query: 136 AERLKTSLQKALEEELEQRP--RLGGLQPGQD---RWRGPAMERPLPMEQARYLEPGIPP 190
AE ++ +Q AL R R L+ Q+ R R PA E P P+++ P
Sbjct: 17 AELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETP-PLQRR-------PS 68
Query: 191 EQPHQRTLEHSLP---PSPRPLPRHTSAREPSAFTLPPPRRSSSPE-----------DPE 236
+ T+E P +P+P A+ P S+SP+ E
Sbjct: 69 VRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAE 128
Query: 237 RDEEVLNHVLRDIELFMGKLEKAQ--AKTSRKKKFGKKNK----DQGGLT-------QAQ 283
R+ ++LNHV D+E F+ +L+K+ A+ ++ G++++ +G LT +A+
Sbjct: 129 REVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAE 188
Query: 284 YIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLT 343
Y D QKIK++F+LL RL + + S+PEL+H LF L I+ A+ V P LT
Sbjct: 189 YTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLT 248
Query: 344 PKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLP--EPSSQA 401
A+ LL+ ++P E+ LW LG +WT + + +E PY+P F W+ P +P S+A
Sbjct: 249 SDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRA 308
Query: 402 PLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVL-YE 460
++DPV + R PQ + H + +P S P ++ A K + Y+
Sbjct: 309 ---WEDPVEKQLQHERRRRQQSAPQVAVNGH--RDLEPESEPQ--LESETAGKWVLCNYD 361
Query: 461 FEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPS 520
F+ARN EL+V Q + LEVLD S++WW V++ AG+ GY+P NIL P PG QSP+
Sbjct: 362 FQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTP-YPGPRLHHSQSPA 420
Query: 521 R 521
R
Sbjct: 421 R 421
Score = 56.2 bits (134), Expect = 8e-08
Identities = 54/180 (30%), Positives = 80/180 (44%), Gaps = 34/180 (18%)
Query: 424 FPQEKTHNHDPQPGDPNSRPS---SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVL 480
+P + H+ NS P +P PA P + ++ PR + + L L
Sbjct: 408 YPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWD----RPRWDSC---DSLNGL 460
Query: 481 DHSKR----WWLVKNEA-------GRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSS 529
D S++ L+ NE GRSG PS + PG + P P S
Sbjct: 461 DPSEKEKFSQMLIVNEELQARLAQGRSG--PSRAV-------PGPRAPEPQLSP----GS 507
Query: 530 RPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRML 589
EV WLQA+ FS+ TV LG LTG+QL ++ EL+ + P+E R+ S++ R +L
Sbjct: 508 DASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLL 567
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 459 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 505
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 459 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 505
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 455 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPG 510
+Q LY F + EL +GE +EV++ + WW KN G+ G +P N + L G
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDG 258
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 53.1 bits (126), Expect = 7e-07
Identities = 21/47 (44%), Positives = 34/47 (72%)
Query: 459 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 505
+++ A+ +EL + + E+L +LD SK WW V+N A R+GY+PSN +E
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 3/59 (5%)
Query: 455 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPG 510
+Q LY F + EL +GE +EV++ + WW KN G+ G +P N + L G
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDG 258
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 50.8 bits (120), Expect = 3e-06
Identities = 22/48 (45%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKN-EAGRSGYIPSNIL 504
LY++ A N R+L +++GEKL+VL + WWL ++ GR GY+PSN +
Sbjct: 66 LYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFV 113
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 49.3 bits (116), Expect = 1e-05
Identities = 25/61 (40%), Positives = 38/61 (62%), Gaps = 2/61 (3%)
Query: 448 PAQPALKMQVLYEFEARNPRELTVVQGEKLEV-LDHSKRWWLVKNEAGRSGYIPSNILEP 506
PA PA + + LY++ A+NP EL + G+ LEV L+ WW V+ G+ G++P + LE
Sbjct: 357 PASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERN-GQRGFVPGSYLEK 415
Query: 507 L 507
L
Sbjct: 416 L 416
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 48.9 bits (115), Expect = 1e-05
Identities = 18/47 (38%), Positives = 33/47 (70%)
Query: 459 YEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILE 505
+++ A+ +EL + + E+L +LD SK WW V+N ++G++PSN +E
Sbjct: 11 FDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVE 57
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 4/69 (5%)
Query: 455 MQVLYEFEARNPRELTVVQGEKLEVLD---HSKRWWLVKNEAGRSGYIPSNILEPLQPGT 511
+Q LY F + N EL +G+ ++V++ + WW + G G +P N + +Q
Sbjct: 195 VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQ-NN 253
Query: 512 PGTQGQSPS 520
P T G PS
Sbjct: 254 PLTSGLEPS 262
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 412 RRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPAL------KMQVLYEFEARN 465
R GS + GS SH +K P+ +P P+PA + K+ LY++ N
Sbjct: 171 RNGSLKPGS-SHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMN 229
Query: 466 PRELTVVQGEKLEVLDHSKR-WWLVKNEAGRSGYIPSN 502
+L + +G++ +L+ S WW +++ G+ GYIPSN
Sbjct: 230 ANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSN 267
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 6/69 (8%)
Query: 444 SSPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSG 497
+SP+ A P LY++E+R +L+ +GE+L+++++++ WWL + G++G
Sbjct: 74 TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG 133
Query: 498 YIPSNILEP 506
YIPSN + P
Sbjct: 134 YIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/69 (33%), Positives = 43/69 (62%), Gaps = 6/69 (8%)
Query: 444 SSPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSG 497
+SP+ A P LY++E+R +L+ +GE+L+++++++ WWL + G++G
Sbjct: 74 TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTG 133
Query: 498 YIPSNILEP 506
YIPSN + P
Sbjct: 134 YIPSNYVAP 142
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 45.1 bits (105), Expect = 2e-04
Identities = 35/124 (28%), Positives = 56/124 (45%), Gaps = 11/124 (8%)
Query: 390 DDWQLPEPSSQAP-LGYQDPVSLRRGSHRLGSTS-----HFP---QEKTHNHDPQPGDPN 440
+D P +AP +G L+ G + T H P + T P P N
Sbjct: 8 EDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHN 67
Query: 441 SR-PSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGR-SGY 498
S P + + + LY++EA + +L+ +G+++ VL+ S WW ++ A R GY
Sbjct: 68 SNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGY 127
Query: 499 IPSN 502
IPSN
Sbjct: 128 IPSN 131
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/52 (40%), Positives = 33/52 (63%), Gaps = 6/52 (11%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDH-----SKRWWLVKNEAGRSGYIPSNIL 504
+Y F+ARNP EL+V +KL++L+ + WWL + G+ GY+PSN +
Sbjct: 1521 VYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVN-GKKGYVPSNYI 1571
Score = 34.3 bits (77), Expect = 0.33
Identities = 17/51 (33%), Positives = 25/51 (49%)
Query: 450 QPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIP 500
+P LY F+A P EL G+K+ +L + WL + GR+G P
Sbjct: 243 EPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFP 293
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 44.7 bits (104), Expect = 2e-04
Identities = 21/52 (40%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +L+ +GEK ++L+ S+ WW ++ G +GYIPSN + P+
Sbjct: 90 LYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV 141
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 44.7 bits (104), Expect = 2e-04
Identities = 19/51 (37%), Positives = 37/51 (72%), Gaps = 2/51 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKNEA-GRSGYIPSNILEP 506
LY++EAR +L+ +GE+ +++++++ WW ++ A G++GYIPSN + P
Sbjct: 99 LYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAP 149
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 44.3 bits (103), Expect = 3e-04
Identities = 24/85 (28%), Positives = 44/85 (51%), Gaps = 2/85 (2%)
Query: 427 EKTHNHDPQPGDPNSRPSSPKPAQPALKMQV-LYEFEARNPRELTVVQGEKLEVLDHSK- 484
+ T N +P P + +P + + LY+++ +P+EL + + E+ +LD S+
Sbjct: 147 DPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI 206
Query: 485 RWWLVKNEAGRSGYIPSNILEPLQP 509
WW V++ G GY+PS+ L P
Sbjct: 207 HWWRVQDRNGHEGYVPSSYLVEKSP 231
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 44.3 bits (103), Expect = 3e-04
Identities = 20/52 (38%), Positives = 36/52 (69%), Gaps = 2/52 (3%)
Query: 458 LYEFEARNPRELTVVQGEKLEVLDHSK-RWWLVKN-EAGRSGYIPSNILEPL 507
LY++EAR +LT +GEK +L++++ WW ++ +G++G IPSN + P+
Sbjct: 85 LYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV 136
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 43.9 bits (102), Expect = 4e-04
Identities = 24/70 (34%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 438 DPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHS--KRWWLVKNEAGR 495
D +S PS P L +V+Y ++A P ELT+ + E LEV++ + W +N+ G+
Sbjct: 458 DSSSSPSGTLRNYP-LTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQ 516
Query: 496 SGYIPSNILE 505
GY+P L+
Sbjct: 517 VGYVPEKYLQ 526
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 43.5 bits (101), Expect = 5e-04
Identities = 28/107 (26%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 407 DPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGD-----PNSRPSSPKPAQPALKMQVLYEF 461
D V L+ R + + ++ T N +P P R + P + + LY +
Sbjct: 15 DGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPY 74
Query: 462 EARNPRELTVVQGEKLEVLDHSKRWWLVKN-EAGRSGYIPSNILEPL 507
+ +P +L+ +GEK++VL+ WW K+ + G+IPSN + L
Sbjct: 75 DGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKL 121
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 13/119 (10%)
Query: 385 QPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPS 444
Q + S D +LPE +Q R L S+ Q T P P
Sbjct: 29 QISLSTDEELPEKYTQ------------RRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLP 76
Query: 445 SPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLD-HSKRWWLVKNEAGRSGYIPSN 502
+ A+ ++++ LY+F R P L + + E+ +L+ ++ WW ++ G G IPSN
Sbjct: 77 PSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSN 135
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 9/86 (10%)
Query: 448 PAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHS------KRWWLVKNEAGRSGYIPS 501
PA P ++++EA ELT+ +G++++VL + WW + +GR G PS
Sbjct: 16 PAGPV--WTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPS 73
Query: 502 NILEPLQPGTPGTQGQSPSRVPMLRL 527
N + P P P Q P +P L
Sbjct: 74 NYVAPGAPAAPAGL-QLPQEIPFHEL 98
Score = 29.6 bits (65), Expect = 8.2
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 16/92 (17%)
Query: 157 LGGLQPGQDRWRGPA----MERP-LPMEQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPR 211
LG P + GP ++ P LP QA + PPE P + T +L +PRP P
Sbjct: 834 LGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPT---TLTFAPRPRPA 890
Query: 212 HTSAR-EP-------SAFTLPPPRRSSSPEDP 235
+ R +P T+ PP R +PE P
Sbjct: 891 ASRPRLDPWKLVSFGRTLTISPPSRPDTPESP 922
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,843,970
Number of Sequences: 37866
Number of extensions: 1598142
Number of successful extensions: 8100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 362
Number of HSP's that attempted gapping in prelim test: 7210
Number of HSP's gapped (non-prelim): 1216
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.