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Search of human proteins with 209863002
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209863002 MAP-kinase activating death domain-containing
protein isoform j [Homo sapiens]
(1541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209863002 MAP-kinase activating death domain-containing prote... 3067 0.0
gi|209862998 MAP-kinase activating death domain-containing prote... 3061 0.0
gi|209862979 MAP-kinase activating death domain-containing prote... 3061 0.0
gi|209862975 MAP-kinase activating death domain-containing prote... 3049 0.0
gi|209571517 MAP-kinase activating death domain-containing prote... 3041 0.0
gi|209862971 MAP-kinase activating death domain-containing prote... 3040 0.0
gi|209862983 MAP-kinase activating death domain-containing prote... 3028 0.0
gi|209862994 MAP-kinase activating death domain-containing prote... 3002 0.0
gi|209862987 MAP-kinase activating death domain-containing prote... 2914 0.0
gi|18860873 MAP-kinase activating death domain-containing protei... 2855 0.0
gi|239735519 SET binding factor 1 [Homo sapiens] 103 1e-21
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 90 2e-17
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 90 2e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 84 1e-15
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 77 1e-13
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 77 1e-13
gi|29788755 SET binding factor 2 [Homo sapiens] 77 2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 72 3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 72 3e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 62 6e-09
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 59 5e-08
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 58 6e-08
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 58 6e-08
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 56 3e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 55 5e-07
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 52 3e-06
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 51 8e-06
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 49 4e-05
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 3067 bits (7951), Expect = 0.0
Identities = 1541/1541 (100%), Positives = 1541/1541 (100%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGG 1140
DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGG
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGG 1140
Query: 1141 EGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY 1200
EGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY
Sbjct: 1141 EGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLY 1200
Query: 1201 EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDD 1260
EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDD
Sbjct: 1201 EGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDD 1260
Query: 1261 EDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGR 1320
EDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGR
Sbjct: 1261 EDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGR 1320
Query: 1321 DLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM 1380
DLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM
Sbjct: 1321 DLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINM 1380
Query: 1381 TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEF 1440
TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEF
Sbjct: 1381 TYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEF 1440
Query: 1441 PVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVS 1500
PVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVS
Sbjct: 1441 PVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVS 1500
Query: 1501 HKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
HKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1501 HKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 3061 bits (7937), Expect = 0.0
Identities = 1541/1544 (99%), Positives = 1541/1544 (99%), Gaps = 3/1544 (0%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE---VSNSSGETLGADSDLSSNAGDG 1137
DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE VSNSSGETLGADSDLSSNAGDG
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDG 1140
Query: 1138 PGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRV 1197
PGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRV
Sbjct: 1141 PGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRV 1200
Query: 1198 YLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRL 1257
YLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRL
Sbjct: 1201 YLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRL 1260
Query: 1258 EDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANL 1317
EDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANL
Sbjct: 1261 EDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANL 1320
Query: 1318 NGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKL 1377
NGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKL
Sbjct: 1321 NGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKL 1380
Query: 1378 INMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELG 1437
INMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELG
Sbjct: 1381 INMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELG 1440
Query: 1438 GEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKE 1497
GEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKE
Sbjct: 1441 GEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKE 1500
Query: 1498 VVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
VVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1501 VVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1544
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 3061 bits (7936), Expect = 0.0
Identities = 1541/1545 (99%), Positives = 1541/1545 (99%), Gaps = 4/1545 (0%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----VSNSSGETLGADSDLSSNAGD 1136
DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE VSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
Query: 1137 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1196
GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
Query: 1197 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1256
VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
Query: 1257 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1316
LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
Query: 1317 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1376
LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
Query: 1377 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1436
LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
Query: 1437 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIK 1496
GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIK
Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIK 1500
Query: 1497 EVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
EVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1501 EVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1545
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 3049 bits (7905), Expect = 0.0
Identities = 1541/1565 (98%), Positives = 1541/1565 (98%), Gaps = 24/1565 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
Query: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
Query: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
Query: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
Query: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----V 1116
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE V
Sbjct: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
Query: 1117 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1176
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
Query: 1177 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1236
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
Query: 1237 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1296
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
Query: 1297 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1356
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
Query: 1357 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1416
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
Query: 1417 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1476
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI
Sbjct: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
Query: 1477 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1536
KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP
Sbjct: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
Query: 1537 RPVSS 1541
RPVSS
Sbjct: 1561 RPVSS 1565
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 3041 bits (7883), Expect = 0.0
Identities = 1541/1587 (97%), Positives = 1541/1587 (97%), Gaps = 46/1587 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
Query: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
Query: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
Query: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
Query: 1098 VIGVSPAVMIRSSSQDSEVS---NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1154
VIGVSPAVMIRSSSQDSEVS NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1200
Query: 1155 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1214
DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ
Sbjct: 1201 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1260
Query: 1215 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1274
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
Query: 1275 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1334
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
Query: 1335 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1394
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
Query: 1395 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1454
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
Query: 1455 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1514
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
Query: 1515 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 3040 bits (7882), Expect = 0.0
Identities = 1541/1588 (97%), Positives = 1541/1588 (97%), Gaps = 47/1588 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
Query: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
Query: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
Query: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
Query: 1098 VIGVSPAVMIRSSSQDSEVS----NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1153
VIGVSPAVMIRSSSQDSEVS NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1200
Query: 1154 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1213
SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1201 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1260
Query: 1214 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1273
QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1261 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1320
Query: 1274 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1333
SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1321 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1380
Query: 1334 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1393
KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1381 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1440
Query: 1394 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1453
RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1441 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1500
Query: 1454 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1513
QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY
Sbjct: 1501 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1560
Query: 1514 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
SVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1588
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 3028 bits (7851), Expect = 0.0
Identities = 1541/1608 (95%), Positives = 1541/1608 (95%), Gaps = 67/1608 (4%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1077
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1140
Query: 1078 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVS----NSSGETLGADSDLSSN 1133
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVS NSSGETLGADSDLSSN
Sbjct: 1141 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1200
Query: 1134 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1193
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1201 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1260
Query: 1194 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1253
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1261 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1320
Query: 1254 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1313
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1321 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1380
Query: 1314 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1373
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1381 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1440
Query: 1374 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1433
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1441 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1500
Query: 1434 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1493
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1501 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1560
Query: 1494 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1608
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 3002 bits (7782), Expect = 0.0
Identities = 1540/1647 (93%), Positives = 1540/1647 (93%), Gaps = 106/1647 (6%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE---- 1115
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1116 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1175
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1176 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1214
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1215 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1274
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1275 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1334
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1335 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1394
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1395 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1454
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1455 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1514
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
Query: 1515 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 2914 bits (7554), Expect = 0.0
Identities = 1470/1477 (99%), Positives = 1472/1477 (99%), Gaps = 5/1477 (0%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----VSNSSGETLGADSDLSSNAGD 1136
DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE VSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
Query: 1137 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1196
GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
Query: 1197 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1256
VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
Query: 1257 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1316
LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
Query: 1317 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1376
LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
Query: 1377 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1436
LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
Query: 1437 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1473
GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 2855 bits (7400), Expect = 0.0
Identities = 1469/1579 (93%), Positives = 1471/1579 (93%), Gaps = 107/1579 (6%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE---- 1115
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1116 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1175
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1176 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1214
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1215 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1274
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1275 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1334
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1335 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1394
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1395 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1454
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1455 VTLEGINLKFMHNQVFIEL 1473
VTLEGINLKFMHNQ F++L
Sbjct: 1561 VTLEGINLKFMHNQ-FLKL 1578
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 103 bits (257), Expect = 1e-21
Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)
Query: 10 RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68
RL DY V+V HP Q ++L+R+P +D + P P + FCQP G +R
Sbjct: 3 RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
Query: 69 MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128
T FV LTD ++ Y C+ F+ + +E T
Sbjct: 61 ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188
E TE E G D + SP A + TL + L H F
Sbjct: 99 -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247
+Y + ++ C E ++G
Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304
LL VP++G + I + Q +Q L +LP SR ++ L L
Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
G+ L + L EHKV+ SR Y L+ + +A+++PL Y F +P+LP A
Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424
++L PTP+IIGV A+F + + + DV + DLD V P E + I P PE L+
Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484
+ H + +S+ P L L DL P P + +
Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532
D R +R F A +LQG++ +R+ P PV+ F +FL R
Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
G YG + FY +F + E+ +
Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
RL +E S +H++ P P
Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
F P DV VDLD+N + ++L
Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)
Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223
K S+S N T +C+LSH+PFF FR+ L + +L + P
Sbjct: 65 KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283
L +E+ S + ++ P P + R+ +++ + AL +
Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
P + L L LG + C +L +LLE K++L S L+ A VAMI
Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
+P ++ P IPL P +A+ +L AP P+I+GV + +F P DV +DLD+N
Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458
+ N + LP P L K L L+S+ TQ EG I +
Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517
TP +F+ + + +++ + A +RF A++L+G++ + R + P
Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
F FL SR R F L++TQ
Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 77.0 bits (188), Expect = 1e-13
Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)
Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344
P PS L D+PL ELLG++ +QV TC+LLE +++L S+DY L +++
Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402
P ++ +P+LP AS L AP PY++G+ + + ++P + L VD+D++
Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
Query: 403 RVIAPTNAEVLP 414
+ P P
Sbjct: 376 FIELPEEFPQFP 387
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 76.6 bits (187), Expect = 2e-13
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%)
Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340
L+ PLH LP+ + LG+ L + +L E+KV+ S + LS + A
Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242
Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400
++++PL+Y +P IP+LP A ++L +PTP+IIGV + F K D DV + DLD
Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296
Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460
+ P L LPEP L Q +++SL P
Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329
Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520
DL+ P + +D R +R F A + QG++ + +R+ PV
Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384
Query: 521 VAFQAGSFLASR 532
+ F +FL R
Sbjct: 385 IHFHKTAFLGQR 396
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69
RL DY ++VG H S ++++R+P +D + P P + FCQP G R+R
Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60
Query: 70 SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118
+ T FV LTD D+ Y C+ FY + + KE+ EG A G
Sbjct: 61 --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
Query: 423 ELKKHLKQALASMSL 437
E + + + L + +
Sbjct: 406 EFVQEVSEILMAFGI 420
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 72.4 bits (176), Expect = 3e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
L+ SP P V K + I VLP P
Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 58.5 bits (140), Expect = 5e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 58.2 bits (139), Expect = 6e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
Score = 31.2 bits (69), Expect = 8.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
Query: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
+ ++ TS F F LT +D G R+G C
Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 58.2 bits (139), Expect = 6e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
+F SL + S L L S V VS + + +P F P
Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
+ T +V + P+ SL + K ALA
Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291
+ L LR + +PV +S + + I +VL + L P F PD +
Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182
Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349
+ +L + VD LQ+ +L E ++V+ S + L+ + A++YP+ +
Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242
Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409
IP+LP + AP PY+IG+ +S + ++ K +DV ++++D+N + +P +
Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298
Query: 410 AEVLPILPEPESLELKKHLKQ 430
L LP LK LK+
Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 55.1 bits (131), Expect = 5e-07
Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657
+S +++ S SDS+ +D SDS D D S SS SS S+ + D+ +
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD- 621
Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717
+ D+S+ E D + +++ +S +S +N SS+++ SS S
Sbjct: 622 ------SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----- 670
Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDS 777
+S+ +DS+ D + S S S + D + + + NS SDS
Sbjct: 671 SSDSSDSSSSSDSS--NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728
Query: 778 DAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SDS SS NS+ S+ S++ S SS N S S S+
Sbjct: 729 SNSSDSSDSS-NSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Score = 54.3 bits (129), Expect = 9e-07
Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
SNS + S S+ +D S SDS D DSS+S SS D + D + + +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743
Query: 657 VDPLTHAALGDASEVE----IDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
D + D+S+ + + ++ + S +S N SS S+ +S+S +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803
Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLR 772
+S+ +DS++ D + S S S + D + G
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG------------- 850
Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SD++S +R+ S NS+ S+ S++ S SS S S S+
Sbjct: 851 ----SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSD 896
Score = 52.0 bits (123), Expect = 4e-06
Identities = 62/284 (21%), Positives = 109/284 (38%), Gaps = 5/284 (1%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS S D S SS SS S+ + D+
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ + + D+S+ + G DS++S + SS S+ +S S ++
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVD-RRQAEIGEGAQKLLRPNSLRLA 774
+S+ +S+ D + S S S + D ++ E + NS
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS---- 935
Query: 775 SDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKA 834
SDS SDS SS +S S++S S +S + S+ S S+ + + + + +
Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995
Query: 835 TPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
S + + S S + S SS+SS++
Sbjct: 996 DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039
Score = 51.2 bits (121), Expect = 8e-06
Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 8/222 (3%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSS----SSYSSLGDFVSEMMKCDIN 651
DS S +++ S + DS S+ +D + SDS D DSS SS SS S+ +
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680
Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
D+ N + ++ S D + DS NS + S+SS ++ SS S
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 712 TVIHGAN--SEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNV-DRRQAEIGEGAQKLLRP 768
+ ++ S +DS++ D + S S SN D + +
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800
Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASS 809
+ +SDS SDS S S NS+ S+ S++ S SS
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842
Score = 50.4 bits (119), Expect = 1e-05
Identities = 58/273 (21%), Positives = 106/273 (38%), Gaps = 4/273 (1%)
Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665
S +SDS ++G+D D DS S D S+ + D+ + +
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574
Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725
+S+ + + + ++ DS NS ++ SS ++ SS S ++ +DS+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634
Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRA 785
+ D K+ S S S + + + + +S +S+S SDS
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694
Query: 786 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRR 845
SS NS+ S+ S++ S +S ++S+ SN + + + + S N
Sbjct: 695 SS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753
Query: 846 ALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
D S S + S SSNSS++
Sbjct: 754 DSSDSSDS-SNSSDSSDSSDSSDSSDSSNSSDS 785
Score = 49.7 bits (117), Expect = 2e-05
Identities = 66/277 (23%), Positives = 115/277 (41%), Gaps = 18/277 (6%)
Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALG--- 666
E D++S D+ +S + D+ + S G +E D DT N D + G
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536
Query: 667 ----DASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPA 722
D+ + + D + DS +S ++ S+SS+ + SS S ++S+ +
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 723 DSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAES 781
DS+ D + + S S S KS+ + +++ + K +S +SDS S
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK--SDSSDSNSSDSSDNS 654
Query: 782 DSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK 841
DS SS NS+ S+ S++ S +SS N S S S+ + + E + S
Sbjct: 655 DSSDSS-NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD----SSNSSESSDSSDSSD 709
Query: 842 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
+ D +S S + S SS+SS++
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS 746
Score = 49.7 bits (117), Expect = 2e-05
Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 5/225 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS SDS D DSS S S D + D + +
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSD 1134
Query: 656 NVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+SE + + + ++ + S++S + SS S+ +S S +
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS--NVDRRQAEIGEGAQKLLRPNSLR 772
+S+ +DS++ D + S S S N ++ + + +S
Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSD 1254
Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTS 817
+ SD+ SDS S + + S S + NHSTS
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Score = 48.9 bits (115), Expect = 4e-05
Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 12/213 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648
DS+S + + S DSDS + DS SDS D DSS S S S+
Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627
Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704
D+ + D + ++ ++S+ + + N + + S++S + SS+S+
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687
Query: 705 TASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS-NVDRRQAEIGEGAQ 763
+S S + +S+ +DS++ D + S S S S + D + +
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 764 KLLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796
+ +SDS SDS SS +S S++S
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780
Score = 47.4 bits (111), Expect = 1e-04
Identities = 47/212 (22%), Positives = 85/212 (40%), Gaps = 11/212 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SD+ + DS + S D S SS SS S+ + D+
Sbjct: 913 DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972
Query: 656 NVDPLTHAALGDASE-------VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
+ D + D+S+ + + N ++ + S++S + SS S+ +S
Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 709 SPSTVIHGANSEPADSTEMDDKA----AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQK 764
S + +S+ +DS++ D + + S S S + D ++ +
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092
Query: 765 LLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796
+ +SDS SDS SS +S SN+S
Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1124
Score = 47.0 bits (110), Expect = 1e-04
Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 28/309 (9%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDY-----------------------DDSSS 633
++S +++ DS S + SDS D DSS+
Sbjct: 661 NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720
Query: 634 SYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASE----VEIDELQNQKEAEEPGPDS 689
S SS D + D + + + D + D+S+ + + ++ + S
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780
Query: 690 ENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS 749
+S N SS S+ +S+S + +S+ +DS++ D + S S S
Sbjct: 781 NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD 840
Query: 750 NVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASS 809
+ D + G + R +S +SDS SDS SS +S S+++ S +S+
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSN-SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899
Query: 810 LYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQ 869
+ S+ S S+ + + + + + S + + S S + S
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959
Query: 870 GRSSNSSEN 878
SSNSS++
Sbjct: 960 SDSSNSSDS 968
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/291 (23%), Positives = 111/291 (38%), Gaps = 21/291 (7%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSG--------SDSMDYDDSSSSYSSLGDFVSEMMKC 648
SNS +++ S SDS + DS SDS D DSS+S S D
Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSS 777
Query: 649 DINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
D + + + D + D+S + DS++S + SS S+ +S+
Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837
Query: 709 SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRP 768
S S+ +DS++ D + S S S + D + +
Sbjct: 838 S---------SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888
Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPT 827
++ +SDS SDS +S S NS+ S+ S+ S SS N S S + S+ + +
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948
Query: 828 KGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
+ + S N D SS S + S SS+SS++
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSS--DSSDSSNSSDSSDSSDSSDSSDS 997
Score = 47.0 bits (110), Expect = 1e-04
Identities = 61/287 (21%), Positives = 110/287 (38%), Gaps = 5/287 (1%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDS--SSSYSSLGDFVSEMMKCDIN 651
DS++ + S SDS + DS SDS D DS SS S+ D D +
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
+ + D + D+S+ + N ++ S++S + SS S+ S S S
Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855
Query: 712 TVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSL 771
+ +++ S D + S S S + D + + + +S
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Query: 772 RLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAR 831
++ SD+ S+S SS NS S++S S +S+ + ++S S ++ +
Sbjct: 916 DSSNSSDS-SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974
Query: 832 EKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
+ + S + + S S + S SSNSS++
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021
Score = 47.0 bits (110), Expect = 1e-04
Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 12/226 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS S D S SS SS S+ + D+
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
N + ++ D+S+ + N ++ + S++S + SS S+ +S S +
Sbjct: 1122 NSSDSSDSS--DSSDSS--DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775
+S+ +DS++ D + S S + D + + + +S
Sbjct: 1178 SNSSDSSDSSDSSDSS--------DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229
Query: 776 DSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 821
DS+ SDS SS +S SN+S S ++S + S S S S
Sbjct: 1230 DSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275
Score = 44.7 bits (104), Expect = 7e-04
Identities = 53/229 (23%), Positives = 91/229 (39%), Gaps = 7/229 (3%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSG--SDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
DS+ + S SDS + DS SDS D DSS S S D D +
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSSDS 1099
Query: 654 TPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
+ + D + D+S+ + N ++ + S++S + SS S+ +S S +
Sbjct: 1100 SDSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157
Query: 714 IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773
+S+ +DS++ D + S S S + D + + +
Sbjct: 1158 DSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1215
Query: 774 ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
+SDS SDS SS ++ S++S S +S + +S S S+
Sbjct: 1216 SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSD 1264
Score = 44.7 bits (104), Expect = 7e-04
Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 15/201 (7%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS + S D S SS SS D D + +
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--DSSDSSDSSDSSDSSD 1170
Query: 656 NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+S+ + + + ++ + S++S + SS S+ +S S +
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDR-RQAEIGEGAQKLLRPNSLRL 773
+S+ +DS++ D + S S SN + Q++ G G
Sbjct: 1231 SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN---------- 1280
Query: 774 ASDSDAESDSRASSPNSTVSN 794
+ SD++SDS S N + S+
Sbjct: 1281 -NGSDSDSDSEGSDSNHSTSD 1300
Score = 40.4 bits (93), Expect = 0.013
Identities = 60/263 (22%), Positives = 101/263 (38%), Gaps = 20/263 (7%)
Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677
++ G DS D+DD S GD + + + N D + ++ GDAS +
Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500
Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737
N ++ G + ++S S+S T S S N + + +DK+ G K
Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546
Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRAS-SPNSTVSNT 795
S S SN D + + + +S SDS SDS +S S NS+ S+
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606
Query: 796 STEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVI 855
S++ S SS ++ S+ + +K + S + + S+
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666
Query: 856 KHSPTVKREPPSPQGRSSNSSEN 878
S + S SSNSS++
Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDS 689
Score = 38.9 bits (89), Expect = 0.039
Identities = 28/95 (29%), Positives = 44/95 (46%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS ++D S +S S DS S+SS + +DS
Sbjct: 602 SDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN 661
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
SSN+ D S +SS + + S+ +S +S
Sbjct: 662 SSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696
Score = 38.1 bits (87), Expect = 0.066
Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D +++ S S+DS S SS DS S + S S DS+ + S ++ +
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
DS +S++ D S + S + SDS ++S+ S+
Sbjct: 649 DSSDNSDSSDSSNSSNSSDSSDSSDS-SDSSSSSDSSNSS 687
Score = 37.4 bits (85), Expect = 0.11
Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSD 1129
++ + S+DS S S+S +D + S + SS S+ SNSS + +DS
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSS 762
Query: 1130 LSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S S SDS +NS+ S+
Sbjct: 763 NSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795
Score = 37.4 bits (85), Expect = 0.11
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 1072 EEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLS 1131
+ S S+DS S SS+ DS S S DS+ SNSS + +DS S
Sbjct: 787 DSSNSSDSSDSSNSSDSSNSSDSSDS-----------SDSSDSDSSNSSDSSNSSDSSDS 835
Query: 1132 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SN+ D SS G+ SDS ++S+ S+
Sbjct: 836 SNSSDSSDSSD-----SSDGSDSDSSNRSDSSNSS 865
Score = 36.6 bits (83), Expect = 0.19
Identities = 33/122 (27%), Positives = 52/122 (42%), Gaps = 4/122 (3%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS +DS
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDS----SDSSDSSDSSDSSDSSDSSDSNESSDSSD 1239
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTS 1190
SS++ D S + S + SDS E++S + + G + + + S TS
Sbjct: 1240 SSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Query: 1191 ED 1192
+D
Sbjct: 1300 DD 1301
Score = 36.2 bits (82), Expect = 0.25
Identities = 31/98 (31%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE-VSNSSGETLGADSD 1129
++ S S+DS S SS DS + S+S DS S+SS + +DS
Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842
Query: 1130 LSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1166
SS++ DG + S SS + SDS +NS+ S+
Sbjct: 843 DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880
Score = 36.2 bits (82), Expect = 0.25
Identities = 32/100 (32%), Positives = 46/100 (46%), Gaps = 5/100 (5%)
Query: 1072 EEKKSQISADSGVSLTS----SSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGAD 1127
E S S+DS S S SS +D S + +SS +S S+SS + +D
Sbjct: 887 ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Query: 1128 SDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1166
S SSN+ D S + + SS SDS +NS+ S+
Sbjct: 947 SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986
Score = 35.4 bits (80), Expect = 0.43
Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 3/100 (3%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D +++ S S+DS S S S +D +S + S S DS+ S+SS + +
Sbjct: 548 DSSDSDSSDSSNSSDSSDS--SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 1127 DSDLSSNAGDGPGGEGSVHLAS-SRGTLSDSEIETNSATS 1165
DS SS++ D S +S S SDS+ +++S+ S
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645
Score = 35.4 bits (80), Expect = 0.43
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 15/110 (13%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS----------SQDSEV 1116
D +++ S S+DS S + SS +D DS + + SS S DS+
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 1117 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
+S E+ +DSD S++ D + +S SDS +NS+ S+
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSD-----SSDNSDSSDSSNSSNSSDSS 669
Score = 35.4 bits (80), Expect = 0.43
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 8/100 (8%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D ++ S S+DS S SS DS S + SS S+ SNSS + +
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS----SNSSDSSDSSDSSDSSNSSDSSNSS 1025
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
DS SS++ D S + S SDS +NS+ S+
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDS----SDSSDSSNSSDSS 1061
Score = 35.0 bits (79), Expect = 0.56
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D + S S+DS S SS DS G SS S+ SNSS + +
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS-----DSSNRSDSSNSSDSSDSS 871
Query: 1127 DSDLSSNAGDGPGGEGSVHLA----SSRGTLSDSEIETNSATST 1166
DS SS++ D S + + SS + SDS +NS+ S+
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Score = 35.0 bits (79), Expect = 0.56
Identities = 29/100 (29%), Positives = 43/100 (43%), Gaps = 11/100 (11%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D + + S+DS S SS DS SS S+ SNSS + +
Sbjct: 961 DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS----------SDSSDSSDSSNSSDSSDSS 1010
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
DS SSN+ D S + + S + SDS ++S+ S+
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049
Score = 34.7 bits (78), Expect = 0.73
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 1/101 (0%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSNSSGETLG 1125
D ++ + S+DS S SS DS S + SS S DS S++S E+
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSD 703
Query: 1126 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
+ S++ D S S SDS +NS+ S+
Sbjct: 704 SSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Score = 34.7 bits (78), Expect = 0.73
Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 3/97 (3%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ +S S+DS S S+S +D S + +SS SE SNSS + +DS
Sbjct: 883 SDSNESSNSSDSSDS--SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSN 940
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSE-IETNSATST 1166
SS++ D S ++S + + S+ ++NS+ S+
Sbjct: 941 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Score = 34.7 bits (78), Expect = 0.73
Identities = 29/100 (29%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D ++ S S+DS S SS D+ S + SS S+ SNSS + +
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS-NSSDSSNSSDSSDSSDSSNSSDSSNSS 960
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
DS SS++ D + S +S+ SDS ++S+ S+
Sbjct: 961 DSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998
Score = 34.3 bits (77), Expect = 0.96
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 16/99 (16%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D ++ + S S+DS S+S +D DS +SS S+ SNSS + +
Sbjct: 703 DSSDSSDSDSSDSSDS-----SNSNSSDSDS----------SNSSDSSDSSNSSDSSDSS 747
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
DS SS++ D S + S + SDS +NS+ S
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDS 785
Score = 34.3 bits (77), Expect = 0.96
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 9/96 (9%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S S DS S+SS + +DS
Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNS--------SDSSDSNSSDSSDSSNSSDSSD 987
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + + S + SDS +NS+ S+
Sbjct: 988 SSDSSDSSDSSDSSNSSDSSDS-SDSSDSSNSSDSS 1022
Score = 33.9 bits (76), Expect = 1.3
Identities = 28/92 (30%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAG 1135
S S S S + SS R+D + S + +SS S+ S+S+ + +DS SSN+
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901
Query: 1136 DGPGGEGSVHLASSRGT-LSDSEIETNSATST 1166
D + S SS + SDS +NS+ ++
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933
Score = 33.9 bits (76), Expect = 1.3
Identities = 33/124 (26%), Positives = 51/124 (41%), Gaps = 2/124 (1%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S S S +S S+SS + +DS
Sbjct: 859 SDSSNSSDSSDSSDSSNSSDSSDSSDS--NESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTS 1190
SSN+ D S ++S + + S+ +S +S ++S S + S S
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 1191 EDVS 1194
D S
Sbjct: 977 SDSS 980
Score = 33.9 bits (76), Expect = 1.3
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ SNSS + +DS
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDS----SDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + + S + SDS ++S+ S+
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076
Score = 33.9 bits (76), Expect = 1.3
Identities = 30/98 (30%), Positives = 44/98 (44%), Gaps = 6/98 (6%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDS----SDSSDSSDSSDSSDSSDSSDSSESSDSSD 1089
Query: 1131 SSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1166
SSN+ D S + S + SDS +NS+ S+
Sbjct: 1090 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127
Score = 33.5 bits (75), Expect = 1.6
Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 1080 ADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPG 1139
+DSG + SS D DS + + SS DS SNSS ++ +DSD S ++
Sbjct: 540 SDSGKGKSDSS---DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 1140 GEGSVHLASSRGTLSDSEIETNSATS 1165
+ +S SDS ++S+ S
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDS 622
Score = 33.5 bits (75), Expect = 1.6
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 7/99 (7%)
Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGAD-- 1127
++ + S S+D+ S SS+ DS S + SS S+ SNSS + +D
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDS----SDSSDSSDSSSSSDSSNSSDSSDSSDSS 696
Query: 1128 -SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
S SS++ D + S SS SDS+ +S +S
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Score = 33.5 bits (75), Expect = 1.6
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + +SS ++ SNSS + ++S
Sbjct: 747 SDSSNSSDSSDSSDSSNSSDSSDSSDS----SDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802
Query: 1131 SSNAGDGPGGEGSVHLASSRGT----LSDSEIETNSATST 1166
SSN+ D S SS + SDS +NS+ S+
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842
Score = 33.1 bits (74), Expect = 2.1
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSP--AVMIRSSSQDSEVSNSSGETLGADS 1128
++ S S+DS S SS DS S + S+S DS+ SNSS + ++S
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 1129 DLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S + SDS ++S+ S+
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNS-SDSSDSSDSSDSS 777
Score = 33.1 bits (74), Expect = 2.1
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ SNSS + +DS
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDS----SDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1191
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S + SDS ++S+ S+
Sbjct: 1192 SSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226
Score = 32.7 bits (73), Expect = 2.8
Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 6/128 (4%)
Query: 1071 TEEKKSQISADSGVSLTSS--SQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADS 1128
++ S S+DS S SS S +D + S + SS S S+S+ + +DS
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS 794
Query: 1129 DLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIR 1188
SSN+ D S S SDS+ +S +S + S S + S
Sbjct: 795 SDSSNSSDSSNSSDS----SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG 850
Query: 1189 TSEDVSQR 1196
+ D S R
Sbjct: 851 SDSDSSNR 858
Score = 32.7 bits (73), Expect = 2.8
Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ +S S+D+ S SS+ DS S S+S DS S+ S ++ +DS
Sbjct: 921 SDSSESSNSSDNSNSSDSSNSSDSSDS--SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
SSN+ D S + S + + S+ +S +S
Sbjct: 979 SSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013
Score = 32.7 bits (73), Expect = 2.8
Identities = 27/95 (28%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS+ DS S SS S+ S+SS + +DS
Sbjct: 945 SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS-----DSSNSSDSSDSSDSSDSSDSSD 999
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
SSN+ D S ++S + + S+ +S +S
Sbjct: 1000 SSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034
Score = 32.7 bits (73), Expect = 2.8
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ SNSS + +DS
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDS----SDSSDSSESSDSSDSSNSSDSSDSSDSSD 1104
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S ++S + SDS ++S+ S+
Sbjct: 1105 SSDSSDSSDSSDSSDSSNSSDS-SDSSDSSDSSDSS 1139
Score = 32.7 bits (73), Expect = 2.8
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDS----SNSSDSSDSSDSSDSSDSSNSSDSSDSSE 1149
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S + SDS +NS+ S+
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184
Score = 32.7 bits (73), Expect = 2.8
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 1163 SDSSDSSDSSDSSDSSNSSDSSDSSDS----SDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1218
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S + SDS +NS+ S+
Sbjct: 1219 SSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253
Score = 32.3 bits (72), Expect = 3.6
Identities = 27/95 (28%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSSDSS-NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1053
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
SSN+ D S + S + S+ +S +S
Sbjct: 1054 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Score = 32.3 bits (72), Expect = 3.6
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 8/96 (8%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS+ DS S + SS S+ S+SS + +DS
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S SDS +NS+ S+
Sbjct: 1066 SSDSSDSSDSSDSSDSSES----SDSSDSSNSSDSS 1097
Score = 32.3 bits (72), Expect = 3.6
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 2/96 (2%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDS-SESSDSSDSSNSSDSSDSSDSSDSSDSSD 1110
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ D S + S + SDS +NS+ S+
Sbjct: 1111 SSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDSS 1145
Score = 32.3 bits (72), Expect = 3.6
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 2/96 (2%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ S S+DS S SS DS S + SS S+ S+SS + +DS
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDS-SESSDSSDSSDSSDSSDSSDSSDSSDSSD 1176
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SSN+ D S + S + SDS ++S+ S+
Sbjct: 1177 SSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211
Score = 32.0 bits (71), Expect = 4.8
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 3/97 (3%)
Query: 1070 ETEEKKSQISADSGVSLTS-SSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADS 1128
E++ S +DS S +S SS +D S + SS S+ S+SS + +DS
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689
Query: 1129 DLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
SS++ + E S SS SDS +NS +S
Sbjct: 690 SDSSDSSN--SSESSDSSDSSDSDSSDSSDSSNSNSS 724
Score = 32.0 bits (71), Expect = 4.8
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
+ + S S+DS S SS DS S + SS S S+SS + +DS
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDS----SNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SSN+ D S + S + SDS ++S+ S+
Sbjct: 779 SSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813
Score = 32.0 bits (71), Expect = 4.8
Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 12/102 (11%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSN---SSGET 1123
D ++ + S S+DS S SS DS S DS+ SN SS +
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS-----SDGSDSDSSNRSDSSNSS 865
Query: 1124 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
+DS SSN+ D S ++S SDS +NS+ S
Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNESSNS----SDSSDSSNSSDS 903
Score = 31.6 bits (70), Expect = 6.2
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSNSSGETLGADSD 1129
++ S S+DS S SS + DS + SS S +S S+ S ++ +DS
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716
Query: 1130 LSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SSN+ + +S SDS ++S+ S+
Sbjct: 717 DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753
Score = 31.6 bits (70), Expect = 6.2
Identities = 31/93 (33%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLS-SNA 1134
S S+DS S +SS DS S + +SS+ S+ S+SS SD S SN+
Sbjct: 668 SSDSSDSSDSSSSSDSSNSSDS----SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 1135 GDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1166
D S SS + SDS +NS+ S+
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756
Score = 31.6 bits (70), Expect = 6.2
Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 5/96 (5%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
++ +S S+DS S SS DS S + SS S+ SNSS + +DS
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1134
Query: 1131 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1166
SS++ + S + S + SDS ++S+ S+
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDS-SDSSDSSDSSDSS 1169
Score = 31.2 bits (69), Expect = 8.1
Identities = 26/96 (27%), Positives = 39/96 (40%), Gaps = 2/96 (2%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGA 1126
D ++ + KS S S S S+ DS S + SS S SNSS + +
Sbjct: 615 DSSDSSDSKSDSSKSESDSSDSDSKSDSSDS--NSSDSSDNSDSSDSSNSSNSSDSSDSS 672
Query: 1127 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNS 1162
DS SS++ D S + S + S+ +S
Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSS 708
Score = 31.2 bits (69), Expect = 8.1
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDS-EVSNSSGETLG 1125
D ++ + + S+DS S +S S + S S S S DS + SNSS +
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770
Query: 1126 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1165
+DS SS++ + S + + S + + S+ +S +S
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS 810
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
Query: 417 PEPESLELKKHLKQ 430
P LK LK+
Sbjct: 284 PSDVVSALKNKLKK 297
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
++GV F +D M ++V LV+L
Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 48.9 bits (115), Expect = 4e-05
Identities = 49/223 (21%), Positives = 93/223 (41%), Gaps = 23/223 (10%)
Query: 659 PLTHAALGDASE-----VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
P A GD ++ + ++ N K ++ + + ++E+ SSSS ++SSS S+
Sbjct: 2516 PWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSS 2575
Query: 714 IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773
G+ +E + + + G G N + A +S
Sbjct: 2576 SSGSETEGEEEGDKNGDGGCGT-----------GGRNCSAASSRAASPASSSSSSSSSSS 2624
Query: 774 ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREK 833
+S S + S S +SS +S+ S++S+ S +SS + S+S S + + + ++
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDE 2684
Query: 834 ATPFPSLKGNRRALVDQKSS-------VIKHSPTVKREPPSPQ 869
A P P+ + +A + K++ HSP K P PQ
Sbjct: 2685 AAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQ 2727
Score = 40.0 bits (92), Expect = 0.017
Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 10/141 (7%)
Query: 615 SEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP------NVDPLTHAALGDA 668
+E ++ S S S SSSS SS G + D NGD N + A A
Sbjct: 2554 AEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPA 2613
Query: 669 SEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMD 728
S + + S +S + SSSS+++SSS S+ ++S + S+
Sbjct: 2614 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTT 2673
Query: 729 DK----AAVGVSKPLPSVPPS 745
D+ ++ + P P+ PS
Sbjct: 2674 DEDSSCSSDDEAAPAPTAGPS 2694
Score = 38.9 bits (89), Expect = 0.039
Identities = 50/191 (26%), Positives = 70/191 (36%), Gaps = 35/191 (18%)
Query: 1007 KDPGLAGRGDPKAMAQLRV--PQLGPRAPSATGKGPKELDTRSLKEEN----FIASIGPE 1060
+DPG G +PK++ L P G P A PK D +E F S P+
Sbjct: 2485 EDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPW--PKATDGDLAQEPGPGLTFEDSGNPK 2542
Query: 1061 VI-KPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIG------------------- 1100
K + EE +S S+ SG S +SSS + G
Sbjct: 2543 SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNC 2602
Query: 1101 -------VSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1153
SPA SSS S S+SS + + S SS++ S +SS +
Sbjct: 2603 SAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2662
Query: 1154 SDSEIETNSAT 1164
S S ++S T
Sbjct: 2663 SSSSSSSSSTT 2673
Score = 35.8 bits (81), Expect = 0.33
Identities = 31/119 (26%), Positives = 43/119 (36%), Gaps = 5/119 (4%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
S+S + + S S S + S S S SSSS SS D S D P
Sbjct: 2631 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPT 2690
Query: 657 VDPLTHAALGDASEVEIDELQNQ-----KEAEEPGPDSENSQENPPLRSSSSTTASSSP 710
P AAL + + + + K+ P P + Q PL+ + A S P
Sbjct: 2691 AGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRP 2749
Score = 33.1 bits (74), Expect = 2.1
Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 990 PDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPK 1041
P ++RS S +T GKD G AG +P A A+ R R PSA KG +
Sbjct: 2298 PSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGR-----GRKPSAKAKGDR 2344
Score = 32.3 bits (72), Expect = 3.6
Identities = 18/69 (26%), Positives = 34/69 (49%)
Query: 108 EKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGS 167
+ G+GG G+ G+ + A+ + + SS S SS S+ S+ + S + + S
Sbjct: 2589 KNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648
Query: 168 RSRNSTLTS 176
S +S+ +S
Sbjct: 2649 SSSSSSSSS 2657
Score = 31.2 bits (69), Expect = 8.1
Identities = 22/68 (32%), Positives = 29/68 (42%)
Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDL 1130
+ S S+ S S +SSS + S S + SSS S S+SS T DS
Sbjct: 2620 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSC 2679
Query: 1131 SSNAGDGP 1138
SS+ P
Sbjct: 2680 SSDDEAAP 2687
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,336,533
Number of Sequences: 37866
Number of extensions: 2994199
Number of successful extensions: 14323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 223
Number of HSP's that attempted gapping in prelim test: 12696
Number of HSP's gapped (non-prelim): 1262
length of query: 1541
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1426
effective length of database: 13,892,928
effective search space: 19811315328
effective search space used: 19811315328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.