Guide to the Human Genome
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Search of human proteins with 209862987

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862987 MAP-kinase activating death domain-containing
protein isoform f [Homo sapiens]
         (1479 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862987 MAP-kinase activating death domain-containing prote...  2941   0.0  
gi|209862979 MAP-kinase activating death domain-containing prote...  2926   0.0  
gi|209862998 MAP-kinase activating death domain-containing prote...  2920   0.0  
gi|209862975 MAP-kinase activating death domain-containing prote...  2914   0.0  
gi|209863002 MAP-kinase activating death domain-containing prote...  2914   0.0  
gi|209862971 MAP-kinase activating death domain-containing prote...  2905   0.0  
gi|209571517 MAP-kinase activating death domain-containing prote...  2899   0.0  
gi|209862983 MAP-kinase activating death domain-containing prote...  2893   0.0  
gi|18860873 MAP-kinase activating death domain-containing protei...  2882   0.0  
gi|209862994 MAP-kinase activating death domain-containing prote...  2867   0.0  
gi|239735519 SET binding factor 1 [Homo sapiens]                      103   1e-21
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...    90   2e-17
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...    90   2e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]             84   1e-15
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]              77   9e-14
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]             77   1e-13
gi|29788755 SET binding factor 2 [Homo sapiens]                        77   2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                  72   3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]               72   3e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    62   5e-09
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi...    62   5e-09
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi...    62   5e-09
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             59   5e-08
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]             58   6e-08
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]             58   6e-08
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi...    56   3e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    55   5e-07
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi...    52   3e-06
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]              51   7e-06
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         49   4e-05

>gi|209862987 MAP-kinase activating death domain-containing protein
            isoform f [Homo sapiens]
          Length = 1479

 Score = 2941 bits (7625), Expect = 0.0
 Identities = 1479/1479 (100%), Positives = 1479/1479 (100%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780

Query: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
            SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840

Query: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
            KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900

Query: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
            KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960

Query: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
            QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020

Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
            AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080

Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
            DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140

Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
            GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200

Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
            VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260

Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
            LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320

Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
            LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380

Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
            LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440

Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW 1479
            GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW
Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW 1479


>gi|209862979 MAP-kinase activating death domain-containing protein
            isoform c [Homo sapiens]
          Length = 1545

 Score = 2926 bits (7586), Expect = 0.0
 Identities = 1474/1477 (99%), Positives = 1476/1477 (99%), Gaps = 1/1477 (0%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780

Query: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
            SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840

Query: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
            KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900

Query: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
            KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960

Query: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
            QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020

Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
            AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080

Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
            DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140

Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
            GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200

Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
            VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260

Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
            LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320

Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
            LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380

Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
            LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440

Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
            GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1477


>gi|209862998 MAP-kinase activating death domain-containing protein
            isoform i [Homo sapiens]
          Length = 1544

 Score = 2920 bits (7570), Expect = 0.0
 Identities = 1473/1477 (99%), Positives = 1475/1477 (99%), Gaps = 2/1477 (0%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780

Query: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
            SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840

Query: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
            KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900

Query: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
            KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960

Query: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
            QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020

Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
            AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080

Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
            DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGD 1139

Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
            GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1140 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1199

Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
            VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1200 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1259

Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
            LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1260 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1319

Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
            LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1320 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1379

Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
            LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1380 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1439

Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
            GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1440 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1476


>gi|209862975 MAP-kinase activating death domain-containing protein
            isoform b [Homo sapiens]
          Length = 1565

 Score = 2914 bits (7555), Expect = 0.0
 Identities = 1474/1497 (98%), Positives = 1476/1497 (98%), Gaps = 21/1497 (1%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780

Query: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
            SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840

Query: 841  K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
            K                    GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841  KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900

Query: 881  FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
            FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 901  FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960

Query: 941  SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
            SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 961  SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020

Query: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
            VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080

Query: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1120
            VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV
Sbjct: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140

Query: 1121 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1180
            SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200

Query: 1181 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1240
            SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260

Query: 1241 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1300
            QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320

Query: 1301 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1360
            SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380

Query: 1361 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1420
            DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440

Query: 1421 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
            KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1497


>gi|209863002 MAP-kinase activating death domain-containing protein
            isoform j [Homo sapiens]
          Length = 1541

 Score = 2914 bits (7554), Expect = 0.0
 Identities = 1470/1477 (99%), Positives = 1472/1477 (99%), Gaps = 5/1477 (0%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780

Query: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
            SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781  SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840

Query: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900
            KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM
Sbjct: 841  KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900

Query: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960
            KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE
Sbjct: 901  KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960

Query: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020
            QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM
Sbjct: 961  QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020

Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080
            AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA
Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080

Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140
            DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE    VSNSSGETLGADSDLSSNAGD
Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----VSNSSGETLGADSDLSSNAGD 1136

Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200
            GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR
Sbjct: 1137 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1196

Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260
            VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR
Sbjct: 1197 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1256

Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320
            LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN
Sbjct: 1257 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1316

Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380
            LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK
Sbjct: 1317 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1376

Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440
            LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL
Sbjct: 1377 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1436

Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
            GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1437 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1473


>gi|209862971 MAP-kinase activating death domain-containing protein
            isoform a [Homo sapiens]
          Length = 1588

 Score = 2905 bits (7532), Expect = 0.0
 Identities = 1474/1520 (96%), Positives = 1476/1520 (97%), Gaps = 44/1520 (2%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900

Query: 858  SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
            SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901  SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960

Query: 918  SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
            SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961  SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020

Query: 978  LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
            LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080

Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
            KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140

Query: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157
            VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1200

Query: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217
            SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1201 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1260

Query: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277
            QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1261 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1320

Query: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337
            SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1321 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1380

Query: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397
            KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1381 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1440

Query: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457
            RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1441 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1500

Query: 1458 QVTLEGINLKFMHNQ-FLKL 1476
            QVTLEGINLKFMHNQ F++L
Sbjct: 1501 QVTLEGINLKFMHNQVFIEL 1520


>gi|209571517 MAP-kinase activating death domain-containing protein
            isoform h [Homo sapiens]
          Length = 1587

 Score = 2899 bits (7516), Expect = 0.0
 Identities = 1473/1520 (96%), Positives = 1475/1520 (97%), Gaps = 45/1520 (2%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900

Query: 858  SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
            SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901  SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960

Query: 918  SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
            SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961  SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020

Query: 978  LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
            LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080

Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
            KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140

Query: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157
            VIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1199

Query: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217
            SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1200 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1259

Query: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277
            QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1260 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1319

Query: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337
            SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1320 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1379

Query: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397
            KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1380 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1439

Query: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457
            RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1440 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1499

Query: 1458 QVTLEGINLKFMHNQ-FLKL 1476
            QVTLEGINLKFMHNQ F++L
Sbjct: 1500 QVTLEGINLKFMHNQVFIEL 1519


>gi|209862983 MAP-kinase activating death domain-containing protein
            isoform e [Homo sapiens]
          Length = 1608

 Score = 2893 bits (7501), Expect = 0.0
 Identities = 1474/1540 (95%), Positives = 1476/1540 (95%), Gaps = 64/1540 (4%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1077
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1140

Query: 1078 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1137
            ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN
Sbjct: 1141 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1200

Query: 1138 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1197
            AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1201 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1260

Query: 1198 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1257
            SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1261 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1320

Query: 1258 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1317
            RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1321 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1380

Query: 1318 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1377
            LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1381 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1440

Query: 1378 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1437
            YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1441 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1500

Query: 1438 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
            PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1501 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1540


>gi|18860873 MAP-kinase activating death domain-containing protein
            isoform g [Homo sapiens]
          Length = 1581

 Score = 2882 bits (7471), Expect = 0.0
 Identities = 1478/1581 (93%), Positives = 1478/1581 (93%), Gaps = 102/1581 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140

Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200

Query: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260

Query: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1218
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG                     KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320

Query: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380

Query: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440

Query: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500

Query: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560

Query: 1459 VTLEGINLKFMHNQFLKLKKW 1479
            VTLEGINLKFMHNQFLKLKKW
Sbjct: 1561 VTLEGINLKFMHNQFLKLKKW 1581


>gi|209862994 MAP-kinase activating death domain-containing protein
            isoform d [Homo sapiens]
          Length = 1647

 Score = 2867 bits (7432), Expect = 0.0
 Identities = 1473/1579 (93%), Positives = 1475/1579 (93%), Gaps = 103/1579 (6%)

Query: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
            MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1    MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60

Query: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
            CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61   CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120

Query: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
            GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121  GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180

Query: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
            SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181  SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240

Query: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
            LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241  LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300

Query: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
            LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301  LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360

Query: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
            ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361  ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420

Query: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
            SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421  SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480

Query: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
            DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481  DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540

Query: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
            KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541  KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600

Query: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
            LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601  LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660

Query: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
            THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661  THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720

Query: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
            PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG                   
Sbjct: 721  PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780

Query: 762  ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
                                    AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781  PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840

Query: 798  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841
            EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK                
Sbjct: 841  EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900

Query: 842  ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897
                GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901  GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960

Query: 898  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957
            LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961  LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020

Query: 958  SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017
            SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080

Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059
            KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI                   P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140

Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119
            EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200

Query: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179
            VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260

Query: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1218
            PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG                     KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320

Query: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278
            MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380

Query: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338
            YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440

Query: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398
            QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500

Query: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458
            NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560

Query: 1459 VTLEGINLKFMHNQ-FLKL 1476
            VTLEGINLKFMHNQ F++L
Sbjct: 1561 VTLEGINLKFMHNQVFIEL 1579


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  103 bits (257), Expect = 1e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60

Query: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98

Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147

Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247
               +Y +    ++ C E ++G                                      
Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169

Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218

Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275

Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329

Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362

Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
           sapiens]
          Length = 1906

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
              +     YG  + FY  +                          SEE  TE       
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474

Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521

Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570

Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
           sapiens]
          Length = 1863

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           +++V+    L+ RYP ED+  F LP  V  FC P G          +  L   ++FV T 
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
              +     YG  + FY  +                          SEE  TE       
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L   SAD               K+ S     T   +C+LSH+PFF  FR+ L  L R   
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
                + G  +                  L +E+  S  +H +             P P 
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L  + P  S   L        L+ LG +  + +L   + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+P  +  P +PL P  +A    +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474

Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
           F     +  P DV  VD+D+N +  I         ILP       KK  K  + +++   
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521

Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
               NL      Q++  L  RP +D     +        G  +  +D+  + A + F   
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570

Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
           A++L+G++ + R +   P          F   +FL SR R    F   + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)

Query: 25  SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
           ++++    ELL RYP ED+  FPLP  V  FC P G        Q +  +   ++FV T 
Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265

Query: 82  TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
                G   YG  + FY +F +    E+                               +
Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294

Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
           L  LSA          RG+       RSR +    + VLS +P F  FR  L  L R   
Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342

Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
               RL                         +E   S  +H++             P P 
Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365

Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
             + R+ +++ P +    L    P  S   L        L+ LG +  + +L  +L EHK
Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422

Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
           +++ S   + L+    A V+MI+PL +  P IPL P  +A    +L AP P+I+G+ +S+
Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479

Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
           F        P DV  VDLD+N +      ++L
Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508


>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
          Length = 1673

 Score = 77.4 bits (189), Expect = 9e-14
 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)

Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223
           K  S+S N T   +C+LSH+PFF  FR+ L  + +L            +  P        
Sbjct: 65  KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105

Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283
                  L +E+  S  + ++             P P   + R+ +++    +  AL  +
Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143

Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
            P  +   L        L  LG + C  +L  +LLE K++L S     L+    A VAMI
Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203

Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
           +P ++  P IPL P  +A+   +L AP P+I+GV + +F        P DV  +DLD+N 
Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257

Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458
           +         N + LP  P    L   K L   L+S+   TQ         EG  I +  
Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306

Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517
                    TP   +F+   +   +  +++  + A +RF   A++L+G++ + R +   P
Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352

Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
                     F    FL SR R    F   L++TQ
Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387


>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
          Length = 1274

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344
           P PS   L D+PL    ELLG++  +QV TC+LLE +++L S+DY  L         +++
Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318

Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402
           P ++    +P+LP   AS    L AP PY++G+ +     +   ++P +  L  VD+D++
Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375

Query: 403 RVIAPTNAEVLP 414
            +  P      P
Sbjct: 376 FIELPEEFPQFP 387


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%)

Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340
           L+  PLH  LP+         + LG+   L +   +L E+KV+  S  +  LS +  A  
Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242

Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400
           ++++PL+Y +P IP+LP   A   ++L +PTP+IIGV + F   K D     DV + DLD
Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296

Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460
              +  P     L  LPEP        L Q  +++SL   P                   
Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329

Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520
              DL+        P    +    +D   R   +R F  A + QG++   + +R+   PV
Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384

Query: 521 VAFQAGSFLASR 532
           + F   +FL  R
Sbjct: 385 IHFHKTAFLGQR 396



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%)

Query: 10  RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69
           RL DY ++VG  H    S     ++++R+P +D  + P P  +  FCQP G    R+R  
Sbjct: 3   RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60

Query: 70  SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118
             +  T FV  LTD D+    Y  C+ FY +    +   KE+ EG A   G
Sbjct: 61  --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)

Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
           +E++IY +L   P+P  G+      +    +   +    P  +   L DFP+    ELLG
Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294

Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
           V+   Q+ TC LLE +++L S+ Y  L        A+++P ++    +P+LP   AS   
Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351

Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
            L AP PY++G+ ++    +   ++P +  L  VD+D++ +  P +      LP+ P  L
Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405

Query: 423 ELKKHLKQALASMSL 437
           E  + + + L +  +
Sbjct: 406 EFVQEVSEILMAFGI 420


>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
          Length = 1198

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)

Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
           ++CV+S +P++++ ++CL  L  L+  C +             + D+  + F   L    
Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152

Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
                             L+ SP P     V   K + I VLP    P            
Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184

Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
            ++D  LHLPL     +  LQ+LTCIL E ++V  S D+  L++    F+A +YPL++  
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244

Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
           P +P+L   M      ++APT +++G     F  +   K  D + L+++D   +
Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293


>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890

Query: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947

Query: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000


>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
          Length = 1137

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254  LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
            L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 833  LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890

Query: 314  TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 891  ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947

Query: 374  IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
            ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 948  LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000


>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
           sapiens]
          Length = 717

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           L+ SP P  G+       LP      L    P  SR   VDF        L V   +++ 
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
             +LLE +V+  +   + LS    A VA++YP  +    IP+LP   AS   ++  PTP+
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
           ++G+ +S  L KL     ++  +V+L S+R I   + E   +LP     +L+  L+QAL
Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)

Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
           A +Y  +RS    P P  G+       LP     ++    P  SR   VDF      + L
Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619

Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
            V   ++V   +LLE +V+  +   + LS    A VA +YP  +    IP+LP   AS  
Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676

Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
            ++ +PTP++IG+  S  L +L     ++V +VDL +++ +   +   E+LP
Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727


>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
          Length = 1009

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           ++ +P P  G+  +    LP      +    P  SR   VDF        L V   + V 
Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
             +LLE +V+  +   + LS    A VA+IYP  +    IP+LP  M     ++ +PTP+
Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
           +IG+ +S      +  + ++V +VDL ++R +   + E   ILP    + L+  L+Q
Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)

Query: 10  RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
           +L +Y V+V   H      A  PEL +++P  LE   +F    +      P+ C    + 
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621

Query: 68  RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
            + ++  TS  F F LT +D G  R+G C
Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649


>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
          Length = 801

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)

Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
           R R  T + LC+LSH P+F  F + L T+  L+  D  +E               + +  
Sbjct: 86  RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132

Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
           +F  SL   + S  L              L S V VS  + +         +P   F  P
Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178

Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
           D  R   +    +L   ++ V  +  + +   +L E +V+L +   + L+  V A  A++
Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238

Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
           YP+ +   +IP LP  +        AP PY+IGV AS    ++  K  +DV ++++D+N 
Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293

Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
            +  T  +V  + P+  SL   +  K ALA
Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323


>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
           sapiens]
          Length = 426

 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%)

Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
           LC+LS+ P+F  + + L TL                                   L +E 
Sbjct: 95  LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122

Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291
            + L   LR +         +PV +S  + + I   +VL  +  L P   F  PD +   
Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182

Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349
            +    +L    + VD    LQ+   +L E ++V+ S   + L+  +    A++YP+ + 
Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242

Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409
              IP+LP  +        AP PY+IG+ +S  + ++  K  +DV ++++D+N + +P +
Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298

Query: 410 AEVLPILPEPESLELKKHLKQ 430
              L  LP      LK  LK+
Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 15/225 (6%)

Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657
           +S  +++ S      SDS+ +D   SDS D D S SS SS     S+      + D+ + 
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD- 621

Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717
                 +  D+S+ E D   +  +++    +S +S +N     SS+++ SS  S      
Sbjct: 622 ------SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----- 670

Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDS 777
           +S+ +DS+   D +    S    S   S    + D   +   + +      NS    SDS
Sbjct: 671 SSDSSDSSSSSDSS--NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728

Query: 778 DAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
              SDS  SS NS+ S+ S++      S  SS   N S S   S+
Sbjct: 729 SNSSDSSDSS-NSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%)

Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
           SNS  +   S        S+ +D S SDS D  DSS+S SS  D  +     D +  + +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743

Query: 657 VDPLTHAALGDASEVE----IDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
            D    +   D+S+        +  +  ++ +    S +S  N    SS S+ +S+S  +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803

Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLR 772
                +S+ +DS++ D   +   S    S   S    + D   +  G             
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG------------- 850

Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
               SD++S +R+ S NS+ S+ S++      S  SS     S S   S+
Sbjct: 851 ----SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSD 896



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 62/284 (21%), Positives = 109/284 (38%), Gaps = 5/284 (1%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS++    + S      SDS  + DS   S   D S SS SS     S+      + D+ 
Sbjct: 760  DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819

Query: 656  NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
            + +    +   D+S+       +       G DS++S  +    SS S+ +S S ++   
Sbjct: 820  SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879

Query: 716  GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVD-RRQAEIGEGAQKLLRPNSLRLA 774
              +S+  +S+   D +    S    S   S    + D    ++  E +      NS    
Sbjct: 880  SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS---- 935

Query: 775  SDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKA 834
            SDS   SDS  SS +S  S++S        S +S    + S+  S S+ +  +  + + +
Sbjct: 936  SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995

Query: 835  TPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
                S   +  +     S     S +      S    SS+SS++
Sbjct: 996  DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 8/222 (3%)

Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSS----SSYSSLGDFVSEMMKCDIN 651
           DS S  +++ S   + DS S+ +D + SDS D  DSS    SS SS     S+      +
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680

Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
            D+ N    + ++    S    D   +         DS NS  +    S+SS ++ SS S
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740

Query: 712 TVIHGAN--SEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNV-DRRQAEIGEGAQKLLRP 768
           +    ++  S  +DS++  D +    S        S   SN  D   +     +      
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800

Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASS 809
           +    +SDS   SDS  S S NS+ S+ S++      S  SS
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 58/273 (21%), Positives = 106/273 (38%), Gaps = 4/273 (1%)

Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665
           S     +SDS    ++G+D  D  DS    S   D  S+      + D+ +      +  
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574

Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725
             +S+ +  +  +   ++    DS NS ++     SS ++ SS  S     ++   +DS+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634

Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRA 785
           + D K+    S    S   S    + +   +     +      +S   +S+S   SDS  
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694

Query: 786 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRR 845
           SS NS+ S+ S++      S +S    ++S+    SN +  +  +    +   S   N  
Sbjct: 695 SS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753

Query: 846 ALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
              D   S    S +      S    SSNSS++
Sbjct: 754 DSSDSSDS-SNSSDSSDSSDSSDSSDSSNSSDS 785



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 66/277 (23%), Positives = 115/277 (41%), Gaps = 18/277 (6%)

Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALG--- 666
           E D++S    D+  +S +  D+ +   S G   +E    D   DT N D   +   G   
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536

Query: 667 ----DASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPA 722
               D+ + + D   +         DS +S ++    S+SS+ + SS S     ++S+ +
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596

Query: 723 DSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAES 781
           DS+   D + +   S    S   S  KS+  + +++  +   K    +S   +SDS   S
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK--SDSSDSNSSDSSDNS 654

Query: 782 DSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK 841
           DS  SS NS+ S+ S++      S +SS   N S S   S+    +  + E +    S  
Sbjct: 655 DSSDSS-NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD----SSNSSESSDSSDSSD 709

Query: 842 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
            +     D  +S    S +      S    SS+SS++
Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS 746



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 5/225 (2%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SDS  + DS SDS D  DSS S  S  D  +     D +  + 
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSD 1134

Query: 656  NVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
            + D    +   D+SE  +  +  +  ++ +    S++S  +    SS S+ +S S  +  
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194

Query: 715  HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS--NVDRRQAEIGEGAQKLLRPNSLR 772
               +S+ +DS++  D +    S        S   S  N     ++  + +      +S  
Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSD 1254

Query: 773  LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTS 817
             +  SD+ SDS   S + + S           S +     NHSTS
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 12/213 (5%)

Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648
           DS+S  + + S     DSDS  + DS        SDS D  DSS S  S     S+    
Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627

Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704
               D+ + D  + ++  ++S+     +  +  N   + +    S++S  +    SS+S+
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687

Query: 705 TASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS-NVDRRQAEIGEGAQ 763
            +S S  +     +S+ +DS++ D   +   S    S   S   S + D   +     + 
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747

Query: 764 KLLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796
                +    +SDS   SDS  SS +S  S++S
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 47/212 (22%), Positives = 85/212 (40%), Gaps = 11/212 (5%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SD+  + DS + S   D S SS SS     S+      + D+ 
Sbjct: 913  DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972

Query: 656  NVDPLTHAALGDASE-------VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
            + D    +   D+S+        +  +  N  ++ +    S++S  +    SS S+ +S 
Sbjct: 973  SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 709  SPSTVIHGANSEPADSTEMDDKA----AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQK 764
            S  +     +S+ +DS++  D +    +   S    S   S    + D  ++     +  
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092

Query: 765  LLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796
                +    +SDS   SDS  SS +S  SN+S
Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1124



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 28/309 (9%)

Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDY-----------------------DDSSS 633
           ++S  +++       DS S     + SDS D                         DSS+
Sbjct: 661 NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720

Query: 634 SYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASE----VEIDELQNQKEAEEPGPDS 689
           S SS  D  +     D +  + + D    +   D+S+        +  +  ++ +    S
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780

Query: 690 ENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS 749
            +S  N    SS S+ +S+S  +     +S+ +DS++ D   +   S    S   S    
Sbjct: 781 NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD 840

Query: 750 NVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASS 809
           + D   +  G  +    R +S   +SDS   SDS  SS +S  S+++        S +S+
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSN-SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899

Query: 810 LYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQ 869
              + S+  S S+ +  +  + + +    S   +  +     S     S +      S  
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959

Query: 870 GRSSNSSEN 878
             SSNSS++
Sbjct: 960 SDSSNSSDS 968



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 69/291 (23%), Positives = 111/291 (38%), Gaps = 21/291 (7%)

Query: 597 SNSQLAEALSVPPERDSDSEPTDDSG--------SDSMDYDDSSSSYSSLGDFVSEMMKC 648
           SNS  +++ S      SDS  + DS         SDS D  DSS+S  S  D        
Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSS 777

Query: 649 DINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
           D +  + + D    +   D+S        +         DS++S  +    SS S+ +S+
Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837

Query: 709 SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRP 768
           S         S+ +DS++  D +    S    S   S    + D   +     +      
Sbjct: 838 S---------SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888

Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPT 827
           ++   +SDS   SDS +S S NS+ S+ S+       S  SS   N S S + S+ +  +
Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948

Query: 828 KGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
             +    +   S   N     D  SS    S +      S    SS+SS++
Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSS--DSSDSSNSSDSSDSSDSSDSSDS 997



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 61/287 (21%), Positives = 110/287 (38%), Gaps = 5/287 (1%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDS--SSSYSSLGDFVSEMMKCDIN 651
            DS++    + S      SDS  + DS   SDS D  DS  SS  S+  D        D +
Sbjct: 736  DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795

Query: 652  GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
              + + D    +   D+S+    +  N  ++      S++S  +    SS S+  S S S
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 712  TVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSL 771
            +    +++    S   D   +   S    S   S    + D   +   + +      +S 
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915

Query: 772  RLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAR 831
              ++ SD+ S+S  SS NS  S++S        S +S+   + ++S S ++       + 
Sbjct: 916  DSSNSSDS-SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974

Query: 832  EKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878
            + +    S   +  +     S     S +      S    SSNSS++
Sbjct: 975  DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 12/226 (5%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SDS  + DS   S   D S SS SS     S+      + D+ 
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121

Query: 656  NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
            N    + ++  D+S+    +  N  ++ +    S++S  +    SS S+ +S S  +   
Sbjct: 1122 NSSDSSDSS--DSSDSS--DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177

Query: 716  GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775
              +S+ +DS++  D +         S   S    + D   +     +      +    +S
Sbjct: 1178 SNSSDSSDSSDSSDSS--------DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229

Query: 776  DSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 821
            DS+  SDS  SS +S  SN+S        S ++S   + S S S S
Sbjct: 1230 DSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 53/229 (23%), Positives = 91/229 (39%), Gaps = 7/229 (3%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSG--SDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
            DS+     + S      SDS  + DS   SDS D  DSS S  S  D        D +  
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSSDS 1099

Query: 654  TPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
            + + D    +   D+S+    +  N  ++ +    S++S  +    SS S+ +S S  + 
Sbjct: 1100 SDSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157

Query: 714  IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773
                +S+ +DS++  D +    S    S   S    + D   +     +      +    
Sbjct: 1158 DSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1215

Query: 774  ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
            +SDS   SDS  SS ++  S++S        S +S    +  +S S S+
Sbjct: 1216 SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSD 1264



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 15/201 (7%)

Query: 596  DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
            DS+     + S      SDS  + DS + S   D S SS SS  D        D +  + 
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--DSSDSSDSSDSSDSSD 1170

Query: 656  NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
            + D    +   D+S+  +  +  +  ++ +    S++S  +    SS S+ +S S  +  
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230

Query: 715  HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDR-RQAEIGEGAQKLLRPNSLRL 773
               +S+ +DS++  D +    S        S   SN +   Q++ G G            
Sbjct: 1231 SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN---------- 1280

Query: 774  ASDSDAESDSRASSPNSTVSN 794
             + SD++SDS  S  N + S+
Sbjct: 1281 -NGSDSDSDSEGSDSNHSTSD 1300



 Score = 40.4 bits (93), Expect = 0.013
 Identities = 60/263 (22%), Positives = 101/263 (38%), Gaps = 20/263 (7%)

Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677
           ++  G DS D+DD S      GD  +   + + N D  +      ++ GDAS    +   
Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500

Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737
           N   ++  G + ++S       S+S T  S S        N    +  + +DK+  G  K
Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546

Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRAS-SPNSTVSNT 795
              S   S   SN  D   +   + +      +S    SDS   SDS +S S NS+ S+ 
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606

Query: 796 STEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVI 855
           S++      S  SS  ++ S+     +    +K     +    S   +  +     S+  
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666

Query: 856 KHSPTVKREPPSPQGRSSNSSEN 878
             S +      S    SSNSS++
Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDS 689



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 36/108 (33%), Positives = 47/108 (43%), Gaps = 4/108 (3%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRS---SSQDSEVSTVVSNS 1123
            D   +    S  S+DS  S  SS      DS  G       RS   +S DS  S+  SNS
Sbjct: 817  DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876

Query: 1124 SGETLGADSDLSSNAGDGPGGEGSVHLASS-RGTLSDSEIETNSATST 1170
            S  +  +DS+ SSN+ D      S    SS     SDS   +NS+ S+
Sbjct: 877  SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 6/105 (5%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  + G+
Sbjct: 792  SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851

Query: 1131 DSDLS-----SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DSD S     SN+ D      S + + S  + SDS   +NS+ S+
Sbjct: 852  DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS-SDSNESSNSSDSS 895



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 28/99 (28%), Positives = 44/99 (44%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS      +    S S DS  S+  S+SS  +  +
Sbjct: 936  SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            DS  SSN+ D      S   ++S  + + S+   +S +S
Sbjct: 996  DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS      +    S+S DS  S   S+SS  +  +
Sbjct: 783  SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS---SDSSDSSNSS 839

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1170
            DS  SS++ DG   + S    SS  +  SDS   +NS+ S+
Sbjct: 840  DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 4/95 (4%)

Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135
            S  S+DS  S  SS      +S      +    SS  DS  S+  S+SS  +  +DS  S
Sbjct: 867  SSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES 926

Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            SN+ D      S + + S    SDS   +NS+ S+
Sbjct: 927  SNSSDNSNSSDSSNSSDS----SDSSDSSNSSDSS 957



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135
            S  S+DS  S  SS   +   S    S      S S DS  S+  SNSS  +  +DS  S
Sbjct: 956  SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015

Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            SN+ D      S + + S  + SDS   ++S+ S+
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 11/126 (8%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S S DS  S+  S+SS     +
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDS-----------SDSSDSSDSSDSSDSSDSNESS 1235

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSP 1190
            DS  SS++ D      S   + S  + SDS  E++S + +  G  +        + + S 
Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295

Query: 1191 IRTSED 1196
              TS+D
Sbjct: 1296 HSTSDD 1301



 Score = 36.2 bits (82), Expect = 0.24
 Identities = 34/101 (33%), Positives = 46/101 (45%), Gaps = 5/101 (4%)

Query: 1071 TEEKKSQISADSGVSLTS-SSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129
            +E   S  S+DS  S +S SS     DS    S      S+S DS  S+  SNSS  +  
Sbjct: 699  SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +DS  SS++ D      S    S     SDS   +NS+ S+
Sbjct: 759  SDSSNSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795



 Score = 35.8 bits (81), Expect = 0.31
 Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 1/132 (0%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D  +++   S  S+DS  S  SS      DS    S +    S S DS+  +  S+S+  
Sbjct: 589  DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1186
                +SD SS++ +      S   + S  + S S+   +S +S     ++S + S     
Sbjct: 649  DSSDNSD-SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 707

Query: 1187 AGSPIRTSEDVS 1198
            + S    S D S
Sbjct: 708  SDSDSSDSSDSS 719



 Score = 35.8 bits (81), Expect = 0.31
 Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 1/104 (0%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D  ++ +  +  S+DS  S +S S  +   S    S      S S DS  S+  S+SS  
Sbjct: 711  DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +  +DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 771  SDSSDSSDSSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 28/104 (26%), Positives = 45/104 (43%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D  +++   S  S+DS  S  S S  ++  S    S +    SS  DS  S+  S+SS  
Sbjct: 548  DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +  +DS  SS++ D           SS         ++NS+ S+
Sbjct: 608  SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 1/100 (1%)

Query: 1072 EEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGAD 1131
            E   S  S+DS  S  S S  +   S    S      S S +S  ++  S+SS  +  +D
Sbjct: 887  ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946

Query: 1132 SDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1170
            S  SSN+ D      S + + SS    SDS   +NS+ S+
Sbjct: 947  SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 13/100 (13%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S+S DS  S+  SNSS  +  +
Sbjct: 912  SDSSDSSNSSDSSESSNSSDNSNSSDS-----------SNSSDSSDSSDSSNSSDSSNSS 960

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D    + S   +S+    SDS   ++S+ S+
Sbjct: 961  DSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998



 Score = 35.4 bits (80), Expect = 0.41
 Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 6/101 (5%)

Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129
            ++ +  S  S+DS  S  SS      DS    S      S S DS  S+  SNSS  +  
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +DS  SS++ D      S    S     SDS   +NS+ S+
Sbjct: 1025 SDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSNSSDSS 1061



 Score = 35.0 bits (79), Expect = 0.54
 Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S+S DS  S+  S+SS  +  +
Sbjct: 735  SDSSNSSDSSDSSDSSNSSDSSDSSDS-----------SNSSDSSDSSDSSDSSDSSNSS 783

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT-----LSDSEIETNSATSTIFGKAHSLKPSIKEK 1185
            DS+ SSN+ D      S   ++S  +      SDS+   +S +S     + S   S    
Sbjct: 784  DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843

Query: 1186 LAGSPIRTSEDVSQR 1200
             + S   +  D S R
Sbjct: 844  SSDSSDGSDSDSSNR 858



 Score = 34.7 bits (78), Expect = 0.70
 Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 3/104 (2%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D   ++   S  S+DS  S  SS      DS    S      S S DS  S+  SNSS  
Sbjct: 970  DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS--SNSSDSSDSSDSSDSSNSSDSSNSSDS 1027

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +  +DS  SS++ D      S   + S  + SDS   ++S+ S+
Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNS-SDSSDSSDSSDSS 1070



 Score = 34.3 bits (77), Expect = 0.92
 Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 4/105 (3%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSG 1125
            D  +++   S  S+DS  S + SS  +D DS    + +    SS S DS  S+  S+S  
Sbjct: 565  DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624

Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            ++  ++SD S +       + +   +S     SDS   +NS+ S+
Sbjct: 625  DSSKSESDSSDSDSKSDSSDSN---SSDSSDNSDSSDSSNSSNSS 666



 Score = 34.3 bits (77), Expect = 0.92
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 14/106 (13%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D  ++    S  ++DS  S  SS+     DS           S S DS  S+  SNSS  
Sbjct: 641  DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-----------SDSSDSSSSSDSSNSSDS 689

Query: 1127 TLGADSDLS---SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            +  +DS  S   S++ D    + S    SS    SDS+   +S +S
Sbjct: 690  SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735



 Score = 34.3 bits (77), Expect = 0.92
 Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 3/104 (2%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D   ++   +  S+DS  S  SS      DS    S +    S+S DS  S+  SNSS  
Sbjct: 644  DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSES 701

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +  +DS   S++ D      S    S     SDS   +NS+ S+
Sbjct: 702  SDSSDSS-DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744



 Score = 34.3 bits (77), Expect = 0.92
 Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 8/106 (7%)

Query: 1071 TEEKKSQISADSGVSLTSS-----SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1125
            ++   S  S+DS  S  SS     S  +D DS    S +    SS  DS  S+  S+SS 
Sbjct: 681  SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS-SDSSNSNSSDSDSSNSSDSSDSSN 739

Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATS 1169
             +  +DS  SSN+ D      S + + S  +   SDS   +NS+ S
Sbjct: 740  SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 32/100 (32%), Positives = 43/100 (43%), Gaps = 5/100 (5%)

Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129
            E++   S   +DS  S +S S      S    S      S S DS  S+  S+SS  +  
Sbjct: 630  ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689

Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            +DS  SSN+      E S    SS    SDS   +NS +S
Sbjct: 690  SDSSDSSNSS-----ESSDSSDSSDSDSSDSSDSSNSNSS 724



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 13/102 (12%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS+     DS           S S DS  S+  S+SS  +  +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSESS 1085

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170
            DS  SSN+ D      S   + S  +   SDS   +NS+ S+
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 7/108 (6%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D  ++ +  S  S+DS  S  SS      DS      +     S  DS   +  SNSS  
Sbjct: 811  DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS---DGSDSDSSNRSDSSNSSDS 867

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLA----SSRGTLSDSEIETNSATST 1170
            +  +DS  SS++ D      S + +    SS  + SDS   +NS+ S+
Sbjct: 868  SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 12/100 (12%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S+S DS  S+  SNSS  +  +
Sbjct: 989  SDSSDSSDSSDSSNSSDSSDSSDSSDS-----------SNSSDSSNSSDSSNSSDSSDSS 1037

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S + + S  + SDS   ++S+ S+
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184



 Score = 33.1 bits (74), Expect = 2.0
 Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 1/100 (1%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  S+      DS    + +    S S +S  S+  SNSS  +  +
Sbjct: 868  SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            +S  +SN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 928  NSSDNSNSSDSSNSSDSSDSSDSSNS-SDSSNSSDSSNSS 966



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 9/104 (8%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D G+ +   S   +    + + SS  +D DS           +SS DS+ S   S+ S +
Sbjct: 541  DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS--------NSSSDSDSSDSDSSDSSD 592

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDS-EIETNSATS 1169
            +  +DS  SS++ D      S   + S  + SDS + E++S+ S
Sbjct: 593  SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 1/101 (0%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S +S  S  SS      DS    S      S S +S  S+  SNSS  +  +
Sbjct: 877  SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSE-IETNSATST 1170
            DS  SS++ D      S   ++S  + + S+  ++NS+ S+
Sbjct: 937  DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 26/99 (26%), Positives = 43/99 (43%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S++S  S  SS      DS      +    SS  +S  S+  SNSS  +  +
Sbjct: 930  SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            DS  SS++ D      S   + S  + + S+   +S +S
Sbjct: 990  DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 12/100 (12%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS+     DS           S S DS  S+  S+SS  +  +
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSNSS 1058

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSS 1097



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDSS 1145



 Score = 32.7 bits (73), Expect = 2.7
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1157 SDSSDSSDSSDSSDSSDSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S   + S  + SDS   +NS+ S+
Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 3/103 (2%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLG 1129
            ++   S  S+DS  S  SS+     DS    + +    SS S DS+ S    +S+  +  
Sbjct: 666  SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725

Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170
            +DS  SS++ D      S   + S  +   SDS   +NS+ S+
Sbjct: 726  SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 11/94 (11%)

Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135
            S  S+DS  S  SS      DS           S+S DS  S+  S+SS  +  +DS  S
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDS-----------SNSSDSSDSSDSSDSSDSSDSSDSSDS 1054

Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            SN+ D      S   + S  +   S+   +S +S
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS    S      S S DS  S+  S+SS  +  +
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDS-SDSSDSSDSSDSS 1172



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S S DS  S+  S+SS  +  +
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-----SDSSDSSDSSDSSDSSDSSDSS 1172

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SSN+ D      S   + S  + SDS   ++S+ S+
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 9/100 (9%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S  S+DS  S  SS      DS           S S DS  S+  SNSS  +  +
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDS--------SDSSDSSDSSDSSNSSDSSDSS 1187

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DS  SS++ D      S   + S  + SDS   ++S+ S+
Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226



 Score = 32.0 bits (71), Expect = 4.5
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 12/100 (12%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            +    S  S+DS  S  SSS     +S           S S DS  S+  S SS  +  +
Sbjct: 660  SNSSNSSDSSDSSDSSDSSSSSDSSNS-----------SDSSDSSDSSNSSESSDSSDSS 708

Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170
            DSD SS++ D      S   +S+    SDS   ++S+ S+
Sbjct: 709  DSD-SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747



 Score = 32.0 bits (71), Expect = 4.5
 Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 4/107 (3%)

Query: 1067 DLGETEEKKSQISADSGVSLTSS-SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1125
            D   ++   S  S+DS  S  SS S  +  +S    S      S S DS  S+  SNSS 
Sbjct: 902  DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSD 961

Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170
             +  +DS   SN+ D      S   + S  +   SDS   +NS+ S+
Sbjct: 962  SSNSSDSS-DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007



 Score = 32.0 bits (71), Expect = 4.5
 Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 1/95 (1%)

Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLGADSDL 1134
            S  S+DS  S  SS      DS      +    SS S DS  S+  S+SS  +  +DS  
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119

Query: 1135 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            SSN+ D      S   + S  +   S+   +S +S
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154



 Score = 31.6 bits (70), Expect = 5.9
 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 3/132 (2%)

Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126
            D   +    S  S+DS  S  SS+     DS    S      S S DS  S+  S+SS  
Sbjct: 852  DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSD-SDSSDS 908

Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1186
            +  +DS  SSN+ D      S   ++S  + + S+   +S +S     ++S   S     
Sbjct: 909  SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968

Query: 1187 AGSPIRTSEDVS 1198
            + S    S D S
Sbjct: 969  SDSNSSDSSDSS 980



 Score = 31.2 bits (69), Expect = 7.8
 Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 2/101 (1%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            ++   S   +DS  S  S S  +   S    S      S S DS  S+  S+SS  +  +
Sbjct: 842  SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901

Query: 1131 DSDLS--SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169
            DSD S  SN+ D      S   + S  +  +S    +S +S
Sbjct: 902  DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942


>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
           sapiens]
          Length = 755

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)

Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
           LC+LS+ P+F  + + L TL                                   L +E 
Sbjct: 95  LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122

Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
            + L   LR        L   PVP +    V++ V    + P +T     P    L ++ 
Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173

Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
                  + V+  LQ+   +L E ++V+ S   + L+  +    A++YP+ +    IP+L
Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229

Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
           P  +        AP PY+IG+ +S  + ++  K  +DV ++++D+N + +P +   L  L
Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283

Query: 417 PEPESLELKKHLKQ 430
           P      LK  LK+
Sbjct: 284 PSDVVSALKNKLKK 297


>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
          Length = 471

 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)

Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
           L  +  P  G+       +P      ++   P  S    VDF   L    L  +  LQ+ 
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248

Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
              +LE K++  +   + LS  + A  A++YP  +    IP++P  + +    +  PTP+
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305

Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
           ++GV   F    +D  M ++V LV+L
Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 49/223 (21%), Positives = 93/223 (41%), Gaps = 23/223 (10%)

Query: 659  PLTHAALGDASE-----VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
            P   A  GD ++     +  ++  N K  ++   + + ++E+    SSSS ++SSS S+ 
Sbjct: 2516 PWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSS 2575

Query: 714  IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773
              G+ +E  +  + +     G            G  N     +     A      +S   
Sbjct: 2576 SSGSETEGEEEGDKNGDGGCGT-----------GGRNCSAASSRAASPASSSSSSSSSSS 2624

Query: 774  ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREK 833
            +S S + S S +SS +S+ S++S+       S +SS   + S+S S +     +  + ++
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDE 2684

Query: 834  ATPFPSLKGNRRALVDQKSS-------VIKHSPTVKREPPSPQ 869
            A P P+   + +A +  K++          HSP  K   P PQ
Sbjct: 2685 AAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQ 2727



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 10/141 (7%)

Query: 615  SEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP------NVDPLTHAALGDA 668
            +E ++ S S S     SSSS SS G       + D NGD        N    +  A   A
Sbjct: 2554 AEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPA 2613

Query: 669  SEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMD 728
            S        +   +      S +S  +    SSSS+++SSS S+    ++S  + S+   
Sbjct: 2614 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTT 2673

Query: 729  DK----AAVGVSKPLPSVPPS 745
            D+    ++   + P P+  PS
Sbjct: 2674 DEDSSCSSDDEAAPAPTAGPS 2694



 Score = 38.1 bits (87), Expect = 0.063
 Identities = 51/196 (26%), Positives = 72/196 (36%), Gaps = 35/196 (17%)

Query: 1007 KDPGLAGRGDPKAMAQLRV--PQLGPRAPSATGKGPKELDTRSLKEEN----FIASIGPE 1060
            +DPG  G  +PK++  L    P  G   P A    PK  D    +E      F  S  P+
Sbjct: 2485 EDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPW--PKATDGDLAQEPGPGLTFEDSGNPK 2542

Query: 1061 VI-KPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIG------------------- 1100
               K   +    EE +S  S+ SG S +SSS  +      G                   
Sbjct: 2543 SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNC 2602

Query: 1101 -------VSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASS 1153
                    SPA    SSS  S  S+  S+SS  +  + S  SS++        S   +SS
Sbjct: 2603 SAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2662

Query: 1154 RGTLSDSEIETNSATS 1169
              + S S   T+  +S
Sbjct: 2663 SSSSSSSSSTTDEDSS 2678



 Score = 35.8 bits (81), Expect = 0.31
 Identities = 31/119 (26%), Positives = 43/119 (36%), Gaps = 5/119 (4%)

Query: 597  SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
            S+S  + + S      S S  +  S S S     SSSS SS  D  S     D     P 
Sbjct: 2631 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPT 2690

Query: 657  VDPLTHAALGDASEVEIDELQNQ-----KEAEEPGPDSENSQENPPLRSSSSTTASSSP 710
              P   AAL   +  +  + +       K+   P P +   Q   PL+  +   A S P
Sbjct: 2691 AGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRP 2749



 Score = 33.1 bits (74), Expect = 2.0
 Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 5/52 (9%)

Query: 990  PDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPK 1041
            P  ++RS   S +T  GKD G AG  +P A A+ R      R PSA  KG +
Sbjct: 2298 PSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGR-----GRKPSAKAKGDR 2344



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 18/69 (26%), Positives = 34/69 (49%)

Query: 108  EKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGS 167
            + G+GG G+ G+  + A+  +    + SS S SS    S+ S+   + S      + + S
Sbjct: 2589 KNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648

Query: 168  RSRNSTLTS 176
             S +S+ +S
Sbjct: 2649 SSSSSSSSS 2657



 Score = 31.6 bits (70), Expect = 5.9
 Identities = 23/72 (31%), Positives = 31/72 (43%)

Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130
            +    S  S+ S  S +SSS  +   S    S +    SSS  S  S+  S+SS  T   
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675

Query: 1131 DSDLSSNAGDGP 1142
            DS  SS+    P
Sbjct: 2676 DSSCSSDDEAAP 2687


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,361,351
Number of Sequences: 37866
Number of extensions: 2860508
Number of successful extensions: 14160
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 12559
Number of HSP's gapped (non-prelim): 1212
length of query: 1479
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1364
effective length of database: 13,892,928
effective search space: 18949953792
effective search space used: 18949953792
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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