BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|209862987 MAP-kinase activating death domain-containing protein isoform f [Homo sapiens] (1479 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|209862987 MAP-kinase activating death domain-containing prote... 2941 0.0 gi|209862979 MAP-kinase activating death domain-containing prote... 2926 0.0 gi|209862998 MAP-kinase activating death domain-containing prote... 2920 0.0 gi|209862975 MAP-kinase activating death domain-containing prote... 2914 0.0 gi|209863002 MAP-kinase activating death domain-containing prote... 2914 0.0 gi|209862971 MAP-kinase activating death domain-containing prote... 2905 0.0 gi|209571517 MAP-kinase activating death domain-containing prote... 2899 0.0 gi|209862983 MAP-kinase activating death domain-containing prote... 2893 0.0 gi|18860873 MAP-kinase activating death domain-containing protei... 2882 0.0 gi|209862994 MAP-kinase activating death domain-containing prote... 2867 0.0 gi|239735519 SET binding factor 1 [Homo sapiens] 103 1e-21 gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 90 2e-17 gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 90 2e-17 gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 84 1e-15 gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 77 9e-14 gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 77 1e-13 gi|29788755 SET binding factor 2 [Homo sapiens] 77 2e-13 gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 72 3e-12 gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 72 3e-12 gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 5e-09 gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 5e-09 gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 62 5e-09 gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 59 5e-08 gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 58 6e-08 gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 58 6e-08 gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 56 3e-07 gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 55 5e-07 gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 52 3e-06 gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 51 7e-06 gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 49 4e-05 >gi|209862987 MAP-kinase activating death domain-containing protein isoform f [Homo sapiens] Length = 1479 Score = 2941 bits (7625), Expect = 0.0 Identities = 1479/1479 (100%), Positives = 1479/1479 (100%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW 1479 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQFLKLKKW 1479 >gi|209862979 MAP-kinase activating death domain-containing protein isoform c [Homo sapiens] Length = 1545 Score = 2926 bits (7586), Expect = 0.0 Identities = 1474/1477 (99%), Positives = 1476/1477 (99%), Gaps = 1/1477 (0%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR Sbjct: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR Sbjct: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN Sbjct: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK Sbjct: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL Sbjct: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L Sbjct: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1477 >gi|209862998 MAP-kinase activating death domain-containing protein isoform i [Homo sapiens] Length = 1544 Score = 2920 bits (7570), Expect = 0.0 Identities = 1473/1477 (99%), Positives = 1475/1477 (99%), Gaps = 2/1477 (0%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGD Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGD 1139 Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR Sbjct: 1140 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1199 Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR Sbjct: 1200 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1259 Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN Sbjct: 1260 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1319 Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK Sbjct: 1320 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1379 Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL Sbjct: 1380 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1439 Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L Sbjct: 1440 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1476 >gi|209862975 MAP-kinase activating death domain-containing protein isoform b [Homo sapiens] Length = 1565 Score = 2914 bits (7555), Expect = 0.0 Identities = 1474/1497 (98%), Positives = 1476/1497 (98%), Gaps = 21/1497 (1%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 Query: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880 K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ Sbjct: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900 Query: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI Sbjct: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960 Query: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES Sbjct: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020 Query: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE Sbjct: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080 Query: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1120 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV Sbjct: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140 Query: 1121 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1180 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP Sbjct: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200 Query: 1181 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1240 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD Sbjct: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260 Query: 1241 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1300 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK Sbjct: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320 Query: 1301 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1360 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD Sbjct: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380 Query: 1361 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1420 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV Sbjct: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440 Query: 1421 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L Sbjct: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1497 >gi|209863002 MAP-kinase activating death domain-containing protein isoform j [Homo sapiens] Length = 1541 Score = 2914 bits (7554), Expect = 0.0 Identities = 1470/1477 (99%), Positives = 1472/1477 (99%), Gaps = 5/1477 (0%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780 Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840 Query: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM Sbjct: 841 KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM 900 Query: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE Sbjct: 901 KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE 960 Query: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM Sbjct: 961 QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM 1020 Query: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA Sbjct: 1021 AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA 1080 Query: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGD 1140 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE VSNSSGETLGADSDLSSNAGD Sbjct: 1081 DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----VSNSSGETLGADSDLSSNAGD 1136 Query: 1141 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1200 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR Sbjct: 1137 GPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQR 1196 Query: 1201 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1260 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR Sbjct: 1197 VYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKR 1256 Query: 1261 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1320 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN Sbjct: 1257 LEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLAN 1316 Query: 1321 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1380 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK Sbjct: 1317 LNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEK 1376 Query: 1381 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1440 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL Sbjct: 1377 LINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPEL 1436 Query: 1441 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L Sbjct: 1437 GGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1473 >gi|209862971 MAP-kinase activating death domain-containing protein isoform a [Homo sapiens] Length = 1588 Score = 2905 bits (7532), Expect = 0.0 Identities = 1474/1520 (96%), Positives = 1476/1520 (97%), Gaps = 44/1520 (2%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780 Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797 AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840 Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900 Query: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960 Query: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020 Query: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080 Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140 Query: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1200 Query: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD Sbjct: 1201 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1260 Query: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI Sbjct: 1261 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1320 Query: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK Sbjct: 1321 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1380 Query: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR Sbjct: 1381 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1440 Query: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL Sbjct: 1441 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1500 Query: 1458 QVTLEGINLKFMHNQ-FLKL 1476 QVTLEGINLKFMHNQ F++L Sbjct: 1501 QVTLEGINLKFMHNQVFIEL 1520 >gi|209571517 MAP-kinase activating death domain-containing protein isoform h [Homo sapiens] Length = 1587 Score = 2899 bits (7516), Expect = 0.0 Identities = 1473/1520 (96%), Positives = 1475/1520 (97%), Gaps = 45/1520 (2%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780 Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797 AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840 Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900 Query: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960 Query: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020 Query: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080 Query: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140 Query: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157 VIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL Sbjct: 1141 VIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1199 Query: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD Sbjct: 1200 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1259 Query: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI Sbjct: 1260 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1319 Query: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK Sbjct: 1320 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1379 Query: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR Sbjct: 1380 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1439 Query: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL Sbjct: 1440 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1499 Query: 1458 QVTLEGINLKFMHNQ-FLKL 1476 QVTLEGINLKFMHNQ F++L Sbjct: 1500 QVTLEGINLKFMHNQVFIEL 1519 >gi|209862983 MAP-kinase activating death domain-containing protein isoform e [Homo sapiens] Length = 1608 Score = 2893 bits (7501), Expect = 0.0 Identities = 1474/1540 (95%), Positives = 1476/1540 (95%), Gaps = 64/1540 (4%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780 Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797 AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840 Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900 Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960 Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020 Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080 Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1077 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1140 Query: 1078 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1137 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN Sbjct: 1141 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1200 Query: 1138 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1197 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV Sbjct: 1201 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1260 Query: 1198 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1257 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD Sbjct: 1261 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1320 Query: 1258 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1317 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ Sbjct: 1321 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1380 Query: 1318 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1377 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW Sbjct: 1381 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1440 Query: 1378 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1437 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG Sbjct: 1441 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1500 Query: 1438 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L Sbjct: 1501 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1540 >gi|18860873 MAP-kinase activating death domain-containing protein isoform g [Homo sapiens] Length = 1581 Score = 2882 bits (7471), Expect = 0.0 Identities = 1478/1581 (93%), Positives = 1478/1581 (93%), Gaps = 102/1581 (6%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780 Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797 AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840 Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900 Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960 Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020 Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080 Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140 Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200 Query: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260 Query: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1218 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320 Query: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380 Query: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440 Query: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500 Query: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560 Query: 1459 VTLEGINLKFMHNQFLKLKKW 1479 VTLEGINLKFMHNQFLKLKKW Sbjct: 1561 VTLEGINLKFMHNQFLKLKKW 1581 >gi|209862994 MAP-kinase activating death domain-containing protein isoform d [Homo sapiens] Length = 1647 Score = 2867 bits (7432), Expect = 0.0 Identities = 1473/1579 (93%), Positives = 1475/1579 (93%), Gaps = 103/1579 (6%) Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60 Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120 Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180 Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240 Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300 Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360 Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420 Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480 Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540 Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600 Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660 Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720 Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780 Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797 AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840 Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900 Query: 842 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 897 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960 Query: 898 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 957 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020 Query: 958 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1017 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080 Query: 1018 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1059 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140 Query: 1060 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1119 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200 Query: 1120 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1179 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260 Query: 1180 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1218 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320 Query: 1219 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1278 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380 Query: 1279 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1338 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440 Query: 1339 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1398 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500 Query: 1399 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1458 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560 Query: 1459 VTLEGINLKFMHNQ-FLKL 1476 VTLEGINLKFMHNQ F++L Sbjct: 1561 VTLEGINLKFMHNQVFIEL 1579 >gi|239735519 SET binding factor 1 [Homo sapiens] Length = 1893 Score = 103 bits (257), Expect = 1e-21 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%) Query: 10 RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68 RL DY V+V HP Q ++L+R+P +D + P P + FCQP G +R Sbjct: 3 RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60 Query: 69 MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128 T FV LTD ++ Y C+ F+ + +E T Sbjct: 61 ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98 Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188 E TE E G D + SP A + TL + L H F Sbjct: 99 -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147 Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247 +Y + ++ C E ++G Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169 Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304 LL VP++G + I + Q +Q L +LP SR ++ L L Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218 Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364 G+ L + L EHKV+ SR Y L+ + +A+++PL Y F +P+LP A Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275 Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424 ++L PTP+IIGV A+F + + + DV + DLD V P E + I P PE L+ Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329 Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484 + H + +S+ P L L DL P P + + Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362 Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532 D R +R F A +LQG++ +R+ P PV+ F +FL R Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408 >gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapiens] Length = 1906 Score = 89.7 bits (221), Expect = 2e-17 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%) Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81 +++V+ L+ RYP ED+ F LP V FC P G + L ++FV T Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262 Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141 + YG + FY + SEE TE Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293 Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201 L SAD K+ S T +C+LSH+PFF FR+ L L R Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335 Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261 + G + L +E+ S +H + P P Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360 Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321 + R+ +++ P + L + P S L L+ LG + + +L + EHK Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417 Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381 +++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + + Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474 Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439 F + P DV VD+D+N + I ILP KK K + +++ Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521 Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499 NL Q++ L RP +D + G + +D+ + A + F Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570 Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546 A++L+G++ + R + P F +FL SR R F + +TQ Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623 >gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapiens] Length = 1863 Score = 89.7 bits (221), Expect = 2e-17 Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%) Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81 +++V+ L+ RYP ED+ F LP V FC P G + L ++FV T Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262 Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141 + YG + FY + SEE TE Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293 Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201 L SAD K+ S T +C+LSH+PFF FR+ L L R Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335 Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261 + G + L +E+ S +H + P P Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360 Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321 + R+ +++ P + L + P S L L+ LG + + +L + EHK Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417 Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381 +++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + + Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474 Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439 F + P DV VD+D+N + I ILP KK K + +++ Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521 Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499 NL Q++ L RP +D + G + +D+ + A + F Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570 Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546 A++L+G++ + R + P F +FL SR R F + +TQ Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623 >gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] Length = 1496 Score = 84.0 bits (206), Expect = 1e-15 Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%) Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81 ++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265 Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141 G YG + FY +F + E+ + Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294 Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201 L LSA RG+ RSR + + VLS +P F FR L L R Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342 Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261 RL +E S +H++ P P Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365 Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321 + R+ +++ P + L P S L L+ LG + + +L +L EHK Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422 Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381 +++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+ Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479 Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413 F P DV VDLD+N + ++L Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508 >gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] Length = 1673 Score = 77.4 bits (189), Expect = 9e-14 Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%) Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223 K S+S N T +C+LSH+PFF FR+ L + +L + P Sbjct: 65 KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105 Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283 L +E+ S + ++ P P + R+ +++ + AL + Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143 Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343 P + L L LG + C +L +LLE K++L S L+ A VAMI Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203 Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403 +P ++ P IPL P +A+ +L AP P+I+GV + +F P DV +DLD+N Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257 Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458 + N + LP P L K L L+S+ TQ EG I + Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306 Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517 TP +F+ + + +++ + A +RF A++L+G++ + R + P Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352 Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546 F FL SR R F L++TQ Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387 >gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] Length = 1274 Score = 77.0 bits (188), Expect = 1e-13 Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%) Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344 P PS L D+PL ELLG++ +QV TC+LLE +++L S+DY L +++ Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318 Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402 P ++ +P+LP AS L AP PY++G+ + + ++P + L VD+D++ Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375 Query: 403 RVIAPTNAEVLP 414 + P P Sbjct: 376 FIELPEEFPQFP 387 >gi|29788755 SET binding factor 2 [Homo sapiens] Length = 1849 Score = 76.6 bits (187), Expect = 2e-13 Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%) Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340 L+ PLH LP+ + LG+ L + +L E+KV+ S + LS + A Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242 Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400 ++++PL+Y +P IP+LP A ++L +PTP+IIGV + F K D DV + DLD Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296 Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460 + P L LPEP L Q +++SL P Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329 Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520 DL+ P + +D R +R F A + QG++ + +R+ PV Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384 Query: 521 VAFQAGSFLASR 532 + F +FL R Sbjct: 385 IHFHKTAFLGQR 396 Score = 56.2 bits (134), Expect = 2e-07 Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%) Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69 RL DY ++VG H S ++++R+P +D + P P + FCQP G R+R Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60 Query: 70 SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118 + T FV LTD D+ Y C+ FY + + KE+ EG A G Sbjct: 61 --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108 >gi|44889475 RAB6 interacting protein 1 [Homo sapiens] Length = 1287 Score = 72.4 bits (176), Expect = 3e-12 Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%) Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305 +E++IY +L P+P G+ + + + P + L DFP+ ELLG Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294 Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365 V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351 Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422 L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405 Query: 423 ELKKHLKQALASMSL 437 E + + + L + + Sbjct: 406 EFVQEVSEILMAFGI 420 >gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] Length = 1198 Score = 72.4 bits (176), Expect = 3e-12 Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%) Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235 ++CV+S +P++++ ++CL L L+ C + + D+ + F L Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152 Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290 L+ SP P V K + I VLP P Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184 Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350 ++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++ Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244 Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404 P +P+L M ++APT +++G F + K D + L+++D + Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293 >gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens] Length = 1137 Score = 61.6 bits (148), Expect = 5e-09 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%) Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313 L+ SP P G+ LP L P SR VDF L V +++ Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890 Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373 +LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+ Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947 Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432 ++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000 >gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens] Length = 1137 Score = 61.6 bits (148), Expect = 5e-09 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%) Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313 L+ SP P G+ LP L P SR VDF L V +++ Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890 Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373 +LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+ Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947 Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432 ++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000 >gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapiens] Length = 717 Score = 61.6 bits (148), Expect = 5e-09 Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%) Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313 L+ SP P G+ LP L P SR VDF L V +++ Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470 Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373 +LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+ Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527 Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432 ++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580 >gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] Length = 871 Score = 58.5 bits (140), Expect = 5e-08 Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%) Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304 A +Y +RS P P G+ LP ++ P SR VDF + L Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619 Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364 V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676 Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414 ++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727 >gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] Length = 1009 Score = 58.2 bits (139), Expect = 6e-08 Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%) Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313 ++ +P P G+ + LP + P SR VDF L V + V Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759 Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373 +LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+ Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816 Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430 +IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871 Score = 31.2 bits (69), Expect = 7.8 Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%) Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67 +L +Y V+V H A PEL +++P LE +F + P+ C + Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621 Query: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94 + ++ TS F F LT +D G R+G C Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649 >gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] Length = 801 Score = 58.2 bits (139), Expect = 6e-08 Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%) Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225 R R T + LC+LSH P+F F + L T+ L+ D +E + + Sbjct: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132 Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285 +F SL + S L L S V VS + + +P F P Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178 Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343 D R + +L ++ V + + + +L E +V+L + + L+ V A A++ Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238 Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403 YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293 Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433 + T +V + P+ SL + K ALA Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323 >gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapiens] Length = 426 Score = 55.8 bits (133), Expect = 3e-07 Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%) Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236 LC+LS+ P+F + + L TL L +E Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122 Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291 + L LR + +PV +S + + I +VL + L P F PD + Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182 Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349 + +L + VD LQ+ +L E ++V+ S + L+ + A++YP+ + Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242 Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409 IP+LP + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298 Query: 410 AEVLPILPEPESLELKKHLKQ 430 L LP LK LK+ Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317 >gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] Length = 1301 Score = 55.1 bits (131), Expect = 5e-07 Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 15/225 (6%) Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657 +S +++ S SDS+ +D SDS D D S SS SS S+ + D+ + Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD- 621 Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717 + D+S+ E D + +++ +S +S +N SS+++ SS S Sbjct: 622 ------SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----- 670 Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDS 777 +S+ +DS+ D + S S S + D + + + NS SDS Sbjct: 671 SSDSSDSSSSSDSS--NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728 Query: 778 DAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822 SDS SS NS+ S+ S++ S SS N S S S+ Sbjct: 729 SNSSDSSDSS-NSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772 Score = 54.3 bits (129), Expect = 9e-07 Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%) Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656 SNS + S S+ +D S SDS D DSS+S SS D + D + + + Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743 Query: 657 VDPLTHAALGDASEVE----IDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712 D + D+S+ + + ++ + S +S N SS S+ +S+S + Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803 Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLR 772 +S+ +DS++ D + S S S + D + G Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG------------- 850 Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822 SD++S +R+ S NS+ S+ S++ S SS S S S+ Sbjct: 851 ----SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSD 896 Score = 52.0 bits (123), Expect = 4e-06 Identities = 62/284 (21%), Positives = 109/284 (38%), Gaps = 5/284 (1%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655 DS++ + S SDS + DS S D S SS SS S+ + D+ Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819 Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715 + + + D+S+ + G DS++S + SS S+ +S S ++ Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879 Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVD-RRQAEIGEGAQKLLRPNSLRLA 774 +S+ +S+ D + S S S + D ++ E + NS Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS---- 935 Query: 775 SDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKA 834 SDS SDS SS +S S++S S +S + S+ S S+ + + + + + Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995 Query: 835 TPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878 S + + S S + S SS+SS++ Sbjct: 996 DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039 Score = 51.2 bits (121), Expect = 7e-06 Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 8/222 (3%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSS----SSYSSLGDFVSEMMKCDIN 651 DS S +++ S + DS S+ +D + SDS D DSS SS SS S+ + Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680 Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711 D+ N + ++ S D + DS NS + S+SS ++ SS S Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740 Query: 712 TVIHGAN--SEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNV-DRRQAEIGEGAQKLLRP 768 + ++ S +DS++ D + S S SN D + + Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800 Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASS 809 + +SDS SDS S S NS+ S+ S++ S SS Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842 Score = 50.4 bits (119), Expect = 1e-05 Identities = 58/273 (21%), Positives = 106/273 (38%), Gaps = 4/273 (1%) Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665 S +SDS ++G+D D DS S D S+ + D+ + + Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574 Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725 +S+ + + + ++ DS NS ++ SS ++ SS S ++ +DS+ Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634 Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRA 785 + D K+ S S S + + + + +S +S+S SDS Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694 Query: 786 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRR 845 SS NS+ S+ S++ S +S ++S+ SN + + + + S N Sbjct: 695 SS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753 Query: 846 ALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878 D S S + S SSNSS++ Sbjct: 754 DSSDSSDS-SNSSDSSDSSDSSDSSDSSNSSDS 785 Score = 49.7 bits (117), Expect = 2e-05 Identities = 66/277 (23%), Positives = 115/277 (41%), Gaps = 18/277 (6%) Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALG--- 666 E D++S D+ +S + D+ + S G +E D DT N D + G Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536 Query: 667 ----DASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPA 722 D+ + + D + DS +S ++ S+SS+ + SS S ++S+ + Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596 Query: 723 DSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAES 781 DS+ D + + S S S KS+ + +++ + K +S +SDS S Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK--SDSSDSNSSDSSDNS 654 Query: 782 DSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK 841 DS SS NS+ S+ S++ S +SS N S S S+ + + E + S Sbjct: 655 DSSDSS-NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD----SSNSSESSDSSDSSD 709 Query: 842 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878 + D +S S + S SS+SS++ Sbjct: 710 SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS 746 Score = 49.7 bits (117), Expect = 2e-05 Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 5/225 (2%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655 DS+ + S SDS + DS SDS D DSS S S D + D + + Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSD 1134 Query: 656 NVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714 + D + D+SE + + + ++ + S++S + SS S+ +S S + Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194 Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS--NVDRRQAEIGEGAQKLLRPNSLR 772 +S+ +DS++ D + S S S N ++ + + +S Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSD 1254 Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTS 817 + SD+ SDS S + + S S + NHSTS Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299 Score = 48.9 bits (115), Expect = 4e-05 Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 12/213 (5%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648 DS+S + + S DSDS + DS SDS D DSS S S S+ Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627 Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704 D+ + D + ++ ++S+ + + N + + S++S + SS+S+ Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687 Query: 705 TASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS-NVDRRQAEIGEGAQ 763 +S S + +S+ +DS++ D + S S S S + D + + Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747 Query: 764 KLLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796 + +SDS SDS SS +S S++S Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780 Score = 47.4 bits (111), Expect = 1e-04 Identities = 47/212 (22%), Positives = 85/212 (40%), Gaps = 11/212 (5%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655 DS+ + S SD+ + DS + S D S SS SS S+ + D+ Sbjct: 913 DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972 Query: 656 NVDPLTHAALGDASE-------VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708 + D + D+S+ + + N ++ + S++S + SS S+ +S Sbjct: 973 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032 Query: 709 SPSTVIHGANSEPADSTEMDDKA----AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQK 764 S + +S+ +DS++ D + + S S S + D ++ + Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092 Query: 765 LLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796 + +SDS SDS SS +S SN+S Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1124 Score = 47.0 bits (110), Expect = 1e-04 Identities = 62/309 (20%), Positives = 116/309 (37%), Gaps = 28/309 (9%) Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDY-----------------------DDSSS 633 ++S +++ DS S + SDS D DSS+ Sbjct: 661 NSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720 Query: 634 SYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASE----VEIDELQNQKEAEEPGPDS 689 S SS D + D + + + D + D+S+ + + ++ + S Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780 Query: 690 ENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS 749 +S N SS S+ +S+S + +S+ +DS++ D + S S S Sbjct: 781 NSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD 840 Query: 750 NVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASS 809 + D + G + R +S +SDS SDS SS +S S+++ S +S+ Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSN-SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSN 899 Query: 810 LYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQ 869 + S+ S S+ + + + + + S + + S S + S Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS 959 Query: 870 GRSSNSSEN 878 SSNSS++ Sbjct: 960 SDSSNSSDS 968 Score = 47.0 bits (110), Expect = 1e-04 Identities = 69/291 (23%), Positives = 111/291 (38%), Gaps = 21/291 (7%) Query: 597 SNSQLAEALSVPPERDSDSEPTDDSG--------SDSMDYDDSSSSYSSLGDFVSEMMKC 648 SNS +++ S SDS + DS SDS D DSS+S S D Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSS 777 Query: 649 DINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708 D + + + D + D+S + DS++S + SS S+ +S+ Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837 Query: 709 SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRP 768 S S+ +DS++ D + S S S + D + + Sbjct: 838 S---------SDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888 Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPT 827 ++ +SDS SDS +S S NS+ S+ S+ S SS N S S + S+ + + Sbjct: 889 SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSS 948 Query: 828 KGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878 + + S N D SS S + S SS+SS++ Sbjct: 949 DSSNSSDSSNSSDSSNSSDSSDSNSS--DSSDSSNSSDSSDSSDSSDSSDS 997 Score = 47.0 bits (110), Expect = 1e-04 Identities = 61/287 (21%), Positives = 110/287 (38%), Gaps = 5/287 (1%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDS--SSSYSSLGDFVSEMMKCDIN 651 DS++ + S SDS + DS SDS D DS SS S+ D D + Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795 Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711 + + D + D+S+ + N ++ S++S + SS S+ S S S Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855 Query: 712 TVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSL 771 + +++ S D + S S S + D + + + +S Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915 Query: 772 RLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAR 831 ++ SD+ S+S SS NS S++S S +S+ + ++S S ++ + Sbjct: 916 DSSNSSDS-SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974 Query: 832 EKATPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 878 + + S + + S S + S SSNSS++ Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021 Score = 47.0 bits (110), Expect = 1e-04 Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 12/226 (5%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655 DS+ + S SDS + DS S D S SS SS S+ + D+ Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121 Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715 N + ++ D+S+ + N ++ + S++S + SS S+ +S S + Sbjct: 1122 NSSDSSDSS--DSSDSS--DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177 Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775 +S+ +DS++ D + S S + D + + + +S Sbjct: 1178 SNSSDSSDSSDSSDSS--------DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229 Query: 776 DSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 821 DS+ SDS SS +S SN+S S ++S + S S S S Sbjct: 1230 DSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275 Score = 44.7 bits (104), Expect = 7e-04 Identities = 53/229 (23%), Positives = 91/229 (39%), Gaps = 7/229 (3%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSG--SDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653 DS+ + S SDS + DS SDS D DSS S S D D + Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSSDS 1099 Query: 654 TPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713 + + D + D+S+ + N ++ + S++S + SS S+ +S S + Sbjct: 1100 SDSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157 Query: 714 IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773 +S+ +DS++ D + S S S + D + + + Sbjct: 1158 DSSDSSDSSDSSDSSDSS--DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1215 Query: 774 ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822 +SDS SDS SS ++ S++S S +S + +S S S+ Sbjct: 1216 SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSD 1264 Score = 44.7 bits (104), Expect = 7e-04 Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 15/201 (7%) Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655 DS+ + S SDS + DS + S D S SS SS D D + + Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--DSSDSSDSSDSSDSSD 1170 Query: 656 NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714 + D + D+S+ + + + ++ + S++S + SS S+ +S S + Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230 Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDR-RQAEIGEGAQKLLRPNSLRL 773 +S+ +DS++ D + S S SN + Q++ G G Sbjct: 1231 SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN---------- 1280 Query: 774 ASDSDAESDSRASSPNSTVSN 794 + SD++SDS S N + S+ Sbjct: 1281 -NGSDSDSDSEGSDSNHSTSD 1300 Score = 40.4 bits (93), Expect = 0.013 Identities = 60/263 (22%), Positives = 101/263 (38%), Gaps = 20/263 (7%) Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677 ++ G DS D+DD S GD + + + N D + ++ GDAS + Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500 Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737 N ++ G + ++S S+S T S S N + + +DK+ G K Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546 Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRAS-SPNSTVSNT 795 S S SN D + + + +S SDS SDS +S S NS+ S+ Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606 Query: 796 STEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVI 855 S++ S SS ++ S+ + +K + S + + S+ Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666 Query: 856 KHSPTVKREPPSPQGRSSNSSEN 878 S + S SSNSS++ Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDS 689 Score = 39.3 bits (90), Expect = 0.028 Identities = 36/108 (33%), Positives = 47/108 (43%), Gaps = 4/108 (3%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRS---SSQDSEVSTVVSNS 1123 D + S S+DS S SS DS G RS +S DS S+ SNS Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876 Query: 1124 SGETLGADSDLSSNAGDGPGGEGSVHLASS-RGTLSDSEIETNSATST 1170 S + +DS+ SSN+ D S SS SDS +NS+ S+ Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924 Score = 37.4 bits (85), Expect = 0.11 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 6/105 (5%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S S DS S+ S+SS + G+ Sbjct: 792 SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851 Query: 1131 DSDLS-----SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DSD S SN+ D S + + S + SDS +NS+ S+ Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS-SDSNESSNSSDSS 895 Score = 37.0 bits (84), Expect = 0.14 Identities = 28/99 (28%), Positives = 44/99 (44%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS + S S DS S+ S+SS + + Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 DS SSN+ D S ++S + + S+ +S +S Sbjct: 996 DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034 Score = 36.6 bits (83), Expect = 0.18 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS + S+S DS S S+SS + + Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS---SDSSDSSNSS 839 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1170 DS SS++ DG + S SS + SDS +NS+ S+ Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880 Score = 36.6 bits (83), Expect = 0.18 Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 4/95 (4%) Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135 S S+DS S SS +S + SS DS S+ S+SS + +DS S Sbjct: 867 SSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES 926 Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 SN+ D S + + S SDS +NS+ S+ Sbjct: 927 SNSSDNSNSSDSSNSSDS----SDSSDSSNSSDSS 957 Score = 36.6 bits (83), Expect = 0.18 Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 1/95 (1%) Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135 S S+DS S SS + S S S S DS S+ SNSS + +DS S Sbjct: 956 SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015 Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 SN+ D S + + S + SDS ++S+ S+ Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049 Score = 36.6 bits (83), Expect = 0.18 Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 11/126 (8%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S DS S+ S+SS + Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDS-----------SDSSDSSDSSDSSDSSDSNESS 1235 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSP 1190 DS SS++ D S + S + SDS E++S + + G + + + S Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295 Query: 1191 IRTSED 1196 TS+D Sbjct: 1296 HSTSDD 1301 Score = 36.2 bits (82), Expect = 0.24 Identities = 34/101 (33%), Positives = 46/101 (45%), Gaps = 5/101 (4%) Query: 1071 TEEKKSQISADSGVSLTS-SSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129 +E S S+DS S +S SS DS S S+S DS S+ SNSS + Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758 Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 +DS SS++ D S S SDS +NS+ S+ Sbjct: 759 SDSSNSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795 Score = 35.8 bits (81), Expect = 0.31 Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 1/132 (0%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D +++ S S+DS S SS DS S + S S DS+ + S+S+ Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1186 +SD SS++ + S + S + S S+ +S +S ++S + S Sbjct: 649 DSSDNSD-SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 707 Query: 1187 AGSPIRTSEDVS 1198 + S S D S Sbjct: 708 SDSDSSDSSDSS 719 Score = 35.8 bits (81), Expect = 0.31 Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 1/104 (0%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D ++ + + S+DS S +S S + S S S S DS S+ S+SS Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 + +DS SSN+ D S + S + SDS ++S+ S+ Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813 Score = 35.4 bits (80), Expect = 0.41 Identities = 28/104 (26%), Positives = 45/104 (43%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D +++ S S+DS S S S ++ S S + SS DS S+ S+SS Sbjct: 548 DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 + +DS SS++ D SS ++NS+ S+ Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651 Score = 35.4 bits (80), Expect = 0.41 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 1/100 (1%) Query: 1072 EEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGAD 1131 E S S+DS S S S + S S S S +S ++ S+SS + +D Sbjct: 887 ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946 Query: 1132 SDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1170 S SSN+ D S + + SS SDS +NS+ S+ Sbjct: 947 SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986 Score = 35.4 bits (80), Expect = 0.41 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 13/100 (13%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S+S DS S+ SNSS + + Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDS-----------SNSSDSSDSSDSSNSSDSSNSS 960 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D + S +S+ SDS ++S+ S+ Sbjct: 961 DSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998 Score = 35.4 bits (80), Expect = 0.41 Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 6/101 (5%) Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129 ++ + S S+DS S SS DS S S S DS S+ SNSS + Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024 Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 +DS SS++ D S S SDS +NS+ S+ Sbjct: 1025 SDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSNSSDSS 1061 Score = 35.0 bits (79), Expect = 0.54 Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S+S DS S+ S+SS + + Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDS-----------SNSSDSSDSSDSSDSSDSSNSS 783 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT-----LSDSEIETNSATSTIFGKAHSLKPSIKEK 1185 DS+ SSN+ D S ++S + SDS+ +S +S + S S Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843 Query: 1186 LAGSPIRTSEDVSQR 1200 + S + D S R Sbjct: 844 SSDSSDGSDSDSSNR 858 Score = 34.7 bits (78), Expect = 0.70 Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 3/104 (2%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D ++ S S+DS S SS DS S S S DS S+ SNSS Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS--SNSSDSSDSSDSSDSSNSSDSSNSSDS 1027 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 + +DS SS++ D S + S + SDS ++S+ S+ Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNS-SDSSDSSDSSDSS 1070 Score = 34.3 bits (77), Expect = 0.92 Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 4/105 (3%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSG 1125 D +++ S S+DS S + SS +D DS + + SS S DS S+ S+S Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624 Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 ++ ++SD S + + + +S SDS +NS+ S+ Sbjct: 625 DSSKSESDSSDSDSKSDSSDSN---SSDSSDNSDSSDSSNSSNSS 666 Score = 34.3 bits (77), Expect = 0.92 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 14/106 (13%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D ++ S ++DS S SS+ DS S S DS S+ SNSS Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-----------SDSSDSSSSSDSSNSSDS 689 Query: 1127 TLGADSDLS---SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 + +DS S S++ D + S SS SDS+ +S +S Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735 Score = 34.3 bits (77), Expect = 0.92 Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 3/104 (2%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D ++ + S+DS S SS DS S + S+S DS S+ SNSS Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSES 701 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 + +DS S++ D S S SDS +NS+ S+ Sbjct: 702 SDSSDSS-DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744 Score = 34.3 bits (77), Expect = 0.92 Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 8/106 (7%) Query: 1071 TEEKKSQISADSGVSLTSS-----SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1125 ++ S S+DS S SS S +D DS S + SS DS S+ S+SS Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS-SDSSNSNSSDSDSSNSSDSSDSSN 739 Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATS 1169 + +DS SSN+ D S + + S + SDS +NS+ S Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785 Score = 33.9 bits (76), Expect = 1.2 Identities = 32/100 (32%), Positives = 43/100 (43%), Gaps = 5/100 (5%) Query: 1070 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1129 E++ S +DS S +S S S S S S DS S+ S+SS + Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689 Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 +DS SSN+ E S SS SDS +NS +S Sbjct: 690 SDSSDSSNSS-----ESSDSSDSSDSDSSDSSDSSNSNSS 724 Score = 33.9 bits (76), Expect = 1.2 Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 13/102 (12%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS+ DS S S DS S+ S+SS + + Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSESS 1085 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170 DS SSN+ D S + S + SDS +NS+ S+ Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127 Score = 33.5 bits (75), Expect = 1.6 Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 7/108 (6%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D ++ + S S+DS S SS DS + S DS + SNSS Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS---DGSDSDSSNRSDSSNSSDS 867 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLA----SSRGTLSDSEIETNSATST 1170 + +DS SS++ D S + + SS + SDS +NS+ S+ Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915 Score = 33.5 bits (75), Expect = 1.6 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 12/100 (12%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S+S DS S+ SNSS + + Sbjct: 989 SDSSDSSDSSDSSNSSDSSDSSDSSDS-----------SNSSDSSNSSDSSNSSDSSDSS 1037 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + + S + SDS ++S+ S+ Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076 Score = 33.5 bits (75), Expect = 1.6 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S S DS S+ S+SS + + Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + S + SDS +NS+ S+ Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184 Score = 33.1 bits (74), Expect = 2.0 Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 1/100 (1%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S S+ DS + + S S +S S+ SNSS + + Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 +S +SN+ D S + S + SDS ++S+ S+ Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNS-SDSSNSSDSSNSS 966 Score = 32.7 bits (73), Expect = 2.7 Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 9/104 (8%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D G+ + S + + + SS +D DS +SS DS+ S S+ S + Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS--------NSSSDSDSSDSDSSDSSD 592 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDS-EIETNSATS 1169 + +DS SS++ D S + S + SDS + E++S+ S Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636 Score = 32.7 bits (73), Expect = 2.7 Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 1/101 (0%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S +S S SS DS S S S +S S+ SNSS + + Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSE-IETNSATST 1170 DS SS++ D S ++S + + S+ ++NS+ S+ Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977 Score = 32.7 bits (73), Expect = 2.7 Identities = 26/99 (26%), Positives = 43/99 (43%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S++S S SS DS + SS +S S+ SNSS + + Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 DS SS++ D S + S + + S+ +S +S Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028 Score = 32.7 bits (73), Expect = 2.7 Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 12/100 (12%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS+ DS S S DS S+ S+SS + + Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSNSS 1058 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + S + SDS +NS+ S+ Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSS 1097 Score = 32.7 bits (73), Expect = 2.7 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S S DS S+ S+SS + + Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + S + SDS +NS+ S+ Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDSS 1145 Score = 32.7 bits (73), Expect = 2.7 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S S DS S+ S+SS + + Sbjct: 1157 SDSSDSSDSSDSSDSSDSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + S + SDS +NS+ S+ Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253 Score = 32.3 bits (72), Expect = 3.5 Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 3/103 (2%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLG 1129 ++ S S+DS S SS+ DS + + SS S DS+ S +S+ + Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725 Query: 1130 ADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170 +DS SS++ D S + S + SDS +NS+ S+ Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768 Score = 32.3 bits (72), Expect = 3.5 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 11/94 (11%) Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1135 S S+DS S SS DS S+S DS S+ S+SS + +DS S Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDS-----------SNSSDSSDSSDSSDSSDSSDSSDSSDS 1054 Query: 1136 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 SN+ D S + S + S+ +S +S Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088 Score = 32.3 bits (72), Expect = 3.5 Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S S DS S+ S+SS + + Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SSN+ D S + S + SDS ++S+ S+ Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDS-SDSSDSSDSSDSS 1172 Score = 32.3 bits (72), Expect = 3.5 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S DS S+ S+SS + + Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-----SDSSDSSDSSDSSDSSDSSDSS 1172 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SSN+ D S + S + SDS ++S+ S+ Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211 Score = 32.3 bits (72), Expect = 3.5 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 9/100 (9%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S S+DS S SS DS S S DS S+ SNSS + + Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDS--------SDSSDSSDSSDSSNSSDSSDSS 1187 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DS SS++ D S + S + SDS ++S+ S+ Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226 Score = 32.0 bits (71), Expect = 4.5 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 12/100 (12%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 + S S+DS S SSS +S S S DS S+ S SS + + Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNS-----------SDSSDSSDSSNSSESSDSSDSS 708 Query: 1131 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1170 DSD SS++ D S +S+ SDS ++S+ S+ Sbjct: 709 DSD-SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747 Score = 32.0 bits (71), Expect = 4.5 Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 4/107 (3%) Query: 1067 DLGETEEKKSQISADSGVSLTSS-SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1125 D ++ S S+DS S SS S + +S S S S DS S+ SNSS Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSD 961 Query: 1126 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1170 + +DS SN+ D S + S + SDS +NS+ S+ Sbjct: 962 SSNSSDSS-DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007 Score = 32.0 bits (71), Expect = 4.5 Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 1/95 (1%) Query: 1076 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLGADSDL 1134 S S+DS S SS DS + SS S DS S+ S+SS + +DS Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119 Query: 1135 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 SSN+ D S + S + S+ +S +S Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154 Score = 31.6 bits (70), Expect = 5.9 Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 3/132 (2%) Query: 1067 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1126 D + S S+DS S SS+ DS S S S DS S+ S+SS Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSD-SDSSDS 908 Query: 1127 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1186 + +DS SSN+ D S ++S + + S+ +S +S ++S S Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968 Query: 1187 AGSPIRTSEDVS 1198 + S S D S Sbjct: 969 SDSNSSDSSDSS 980 Score = 31.2 bits (69), Expect = 7.8 Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 2/101 (1%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 ++ S +DS S S S + S S S S DS S+ S+SS + + Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901 Query: 1131 DSDLS--SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1169 DSD S SN+ D S + S + +S +S +S Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942 >gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapiens] Length = 755 Score = 52.4 bits (124), Expect = 3e-06 Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%) Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236 LC+LS+ P+F + + L TL L +E Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122 Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296 + L LR L PVP + V++ V + P +T P L ++ Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173 Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356 + V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229 Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416 P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283 Query: 417 PEPESLELKKHLKQ 430 P LK LK+ Sbjct: 284 PSDVVSALKNKLKK 297 >gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] Length = 471 Score = 51.2 bits (121), Expect = 7e-06 Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%) Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313 L + P G+ +P ++ P S VDF L L + LQ+ Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248 Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373 +LE K++ + + LS + A A++YP + IP++P + + + PTP+ Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305 Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399 ++GV F +D M ++V LV+L Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330 >gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] Length = 2968 Score = 48.9 bits (115), Expect = 4e-05 Identities = 49/223 (21%), Positives = 93/223 (41%), Gaps = 23/223 (10%) Query: 659 PLTHAALGDASE-----VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713 P A GD ++ + ++ N K ++ + + ++E+ SSSS ++SSS S+ Sbjct: 2516 PWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSS 2575 Query: 714 IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRL 773 G+ +E + + + G G N + A +S Sbjct: 2576 SSGSETEGEEEGDKNGDGGCGT-----------GGRNCSAASSRAASPASSSSSSSSSSS 2624 Query: 774 ASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREK 833 +S S + S S +SS +S+ S++S+ S +SS + S+S S + + + ++ Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDE 2684 Query: 834 ATPFPSLKGNRRALVDQKSS-------VIKHSPTVKREPPSPQ 869 A P P+ + +A + K++ HSP K P PQ Sbjct: 2685 AAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQ 2727 Score = 40.0 bits (92), Expect = 0.017 Identities = 36/141 (25%), Positives = 58/141 (41%), Gaps = 10/141 (7%) Query: 615 SEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP------NVDPLTHAALGDA 668 +E ++ S S S SSSS SS G + D NGD N + A A Sbjct: 2554 AEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPA 2613 Query: 669 SEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMD 728 S + + S +S + SSSS+++SSS S+ ++S + S+ Sbjct: 2614 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTT 2673 Query: 729 DK----AAVGVSKPLPSVPPS 745 D+ ++ + P P+ PS Sbjct: 2674 DEDSSCSSDDEAAPAPTAGPS 2694 Score = 38.1 bits (87), Expect = 0.063 Identities = 51/196 (26%), Positives = 72/196 (36%), Gaps = 35/196 (17%) Query: 1007 KDPGLAGRGDPKAMAQLRV--PQLGPRAPSATGKGPKELDTRSLKEEN----FIASIGPE 1060 +DPG G +PK++ L P G P A PK D +E F S P+ Sbjct: 2485 EDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPW--PKATDGDLAQEPGPGLTFEDSGNPK 2542 Query: 1061 VI-KPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIG------------------- 1100 K + EE +S S+ SG S +SSS + G Sbjct: 2543 SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNC 2602 Query: 1101 -------VSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASS 1153 SPA SSS S S+ S+SS + + S SS++ S +SS Sbjct: 2603 SAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2662 Query: 1154 RGTLSDSEIETNSATS 1169 + S S T+ +S Sbjct: 2663 SSSSSSSSSTTDEDSS 2678 Score = 35.8 bits (81), Expect = 0.31 Identities = 31/119 (26%), Positives = 43/119 (36%), Gaps = 5/119 (4%) Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656 S+S + + S S S + S S S SSSS SS D S D P Sbjct: 2631 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPT 2690 Query: 657 VDPLTHAALGDASEVEIDELQNQ-----KEAEEPGPDSENSQENPPLRSSSSTTASSSP 710 P AAL + + + + K+ P P + Q PL+ + A S P Sbjct: 2691 AGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRP 2749 Score = 33.1 bits (74), Expect = 2.0 Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 5/52 (9%) Query: 990 PDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPK 1041 P ++RS S +T GKD G AG +P A A+ R R PSA KG + Sbjct: 2298 PSAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGR-----GRKPSAKAKGDR 2344 Score = 32.3 bits (72), Expect = 3.5 Identities = 18/69 (26%), Positives = 34/69 (49%) Query: 108 EKGEGGAGSRGKEGTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGS 167 + G+GG G+ G+ + A+ + + SS S SS S+ S+ + S + + S Sbjct: 2589 KNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648 Query: 168 RSRNSTLTS 176 S +S+ +S Sbjct: 2649 SSSSSSSSS 2657 Score = 31.6 bits (70), Expect = 5.9 Identities = 23/72 (31%), Positives = 31/72 (43%) Query: 1071 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1130 + S S+ S S +SSS + S S + SSS S S+ S+SS T Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675 Query: 1131 DSDLSSNAGDGP 1142 DS SS+ P Sbjct: 2676 DSSCSSDDEAAP 2687 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.132 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 58,361,351 Number of Sequences: 37866 Number of extensions: 2860508 Number of successful extensions: 14160 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 42 Number of HSP's successfully gapped in prelim test: 227 Number of HSP's that attempted gapping in prelim test: 12559 Number of HSP's gapped (non-prelim): 1212 length of query: 1479 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1364 effective length of database: 13,892,928 effective search space: 18949953792 effective search space used: 18949953792 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.