Search of human proteins with 208431757

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|208431757 KLRAQ motif containing 1 isoform 3 [Homo sapiens]
         (734 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|208431757 KLRAQ motif containing 1 isoform 3 [Homo sapiens]       1409   0.0  
gi|208431754 KLRAQ motif containing 1 isoform 1 [Homo sapiens]       1409   0.0  
gi|24308420 KLRAQ motif containing 1 isoform 2 [Homo sapiens]        1380   0.0  
gi|71061468 centromere protein E [Homo sapiens]                        66   1e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             64   5e-10
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    63   9e-10
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    63   1e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   62   1e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    62   2e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    62   2e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    60   6e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    60   6e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    60   6e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    60   6e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    60   7e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    60   7e-09
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    59   2e-08
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    59   2e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       59   2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    59   2e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     59   2e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     58   3e-08
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     58   4e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    57   8e-08
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]               55   2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens]                       55   3e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    55   3e-07
gi|55770834 centromere protein F [Homo sapiens]                        55   3e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    54   5e-07
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    53   1e-06

>gi|208431757 KLRAQ motif containing 1 isoform 3 [Homo sapiens]
          Length = 734

 Score = 1409 bits (3648), Expect = 0.0
 Identities = 734/734 (100%), Positives = 734/734 (100%)

Query: 1   MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
           MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS
Sbjct: 1   MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60

Query: 61  VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
           VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM
Sbjct: 61  VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120

Query: 121 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
           ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV
Sbjct: 121 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180

Query: 181 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240
           PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV
Sbjct: 181 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240

Query: 241 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300
           DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL
Sbjct: 241 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300

Query: 301 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 360
           TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA
Sbjct: 301 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 360

Query: 361 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 420
           LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN
Sbjct: 361 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 420

Query: 421 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480
           DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA
Sbjct: 421 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480

Query: 481 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540
           YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA
Sbjct: 481 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540

Query: 541 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
           QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI
Sbjct: 541 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600

Query: 601 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 660
           GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA
Sbjct: 601 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 660

Query: 661 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
           EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL
Sbjct: 661 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720

Query: 721 KMSSKGNSKKNKSR 734
           KMSSKGNSKKNKSR
Sbjct: 721 KMSSKGNSKKNKSR 734


>gi|208431754 KLRAQ motif containing 1 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1409 bits (3648), Expect = 0.0
 Identities = 734/734 (100%), Positives = 734/734 (100%)

Query: 1   MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
           MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS
Sbjct: 47  MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 106

Query: 61  VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
           VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM
Sbjct: 107 VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 166

Query: 121 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
           ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV
Sbjct: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226

Query: 181 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240
           PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV
Sbjct: 227 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 286

Query: 241 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300
           DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL
Sbjct: 287 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 346

Query: 301 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 360
           TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA
Sbjct: 347 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 406

Query: 361 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 420
           LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN
Sbjct: 407 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 466

Query: 421 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480
           DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA
Sbjct: 467 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 526

Query: 481 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540
           YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA
Sbjct: 527 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 586

Query: 541 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
           QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI
Sbjct: 587 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 646

Query: 601 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 660
           GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA
Sbjct: 647 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 706

Query: 661 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
           EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL
Sbjct: 707 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 766

Query: 721 KMSSKGNSKKNKSR 734
           KMSSKGNSKKNKSR
Sbjct: 767 KMSSKGNSKKNKSR 780


>gi|24308420 KLRAQ motif containing 1 isoform 2 [Homo sapiens]
          Length = 769

 Score = 1380 bits (3573), Expect = 0.0
 Identities = 723/734 (98%), Positives = 723/734 (98%), Gaps = 11/734 (1%)

Query: 1   MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
           MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS
Sbjct: 47  MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 106

Query: 61  VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
           VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM
Sbjct: 107 VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 166

Query: 121 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
           ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV
Sbjct: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226

Query: 181 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240
           PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV
Sbjct: 227 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 286

Query: 241 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300
           DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL
Sbjct: 287 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 346

Query: 301 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 360
           TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA
Sbjct: 347 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 406

Query: 361 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 420
           LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN
Sbjct: 407 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 466

Query: 421 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480
           DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA
Sbjct: 467 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 526

Query: 481 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540
           YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA
Sbjct: 527 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 586

Query: 541 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
           QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL 
Sbjct: 587 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL- 645

Query: 601 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 660
                     VPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA
Sbjct: 646 ----------VPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 695

Query: 661 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
           EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL
Sbjct: 696 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 755

Query: 721 KMSSKGNSKKNKSR 734
           KMSSKGNSKKNKSR
Sbjct: 756 KMSSKGNSKKNKSR 769


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 155/750 (20%), Positives = 301/750 (40%), Gaps = 142/750 (18%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K + L  +  E D L    +    RV+ L +E+  ++      + + +S+ Q  Q  K++
Sbjct: 766  KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTL 825

Query: 62   ---FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRK 118
               F++  +  +EENER++ +     ++ +  +    S L  L+TE +     +   TR+
Sbjct: 826  HMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD----SSLGALKTELSYKTQELQEKTRE 881

Query: 119  YMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINE 178
              E + +++  K +LE +  TL+   +E  L TE+           L   LEE  ++  E
Sbjct: 882  VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK-----------LQQTLEEVKTLTQE 930

Query: 179  KVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIF 238
            K   +D K  Q +     L   R QLK         + + D V   +N  T  + R  + 
Sbjct: 931  K---DDLKQLQES-----LQIERDQLK---------SDIHDTVN--MNIDTQEQLRNALE 971

Query: 239  PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSE 298
             +    +TI+ L  K S+ +  N      +EE      +   +  V + +        ++
Sbjct: 972  SLKQHQETINTLKSKISEEVSRNLH----MEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027

Query: 299  HLTSYICFLRKILPYQLK---SLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTY 355
             LT+ +    +I+  Q K    ++E+ E      ++ A   +L  D+K+   +  + Q  
Sbjct: 1028 TLTADVKD-NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEE 1086

Query: 356  IALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQK 415
            + LL     +   ++    +  +   G           ++S+   + A +E +L   +Q+
Sbjct: 1087 LRLLGDELKKQQEIVAQEKNHAIKKEG-----------ELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 416  LITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYK 475
            L      +L+    ++    KI                         I  L  E  L+ K
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINE-----------------------IENLKNE--LKNK 1170

Query: 476  KKAAAYMKSLRKPLLESV--PYEEALA---NRRILLSSTESREGLAQQVQQSLEKISKLE 530
            +    +M++ R  L + +   YEE  +    R++L    +S E     ++  + +I    
Sbjct: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230

Query: 531  -QEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKA 589
             Q KE    E ++A I L KE+Q   D+L+ +       ++++ A + NT   +++  K 
Sbjct: 1231 LQTKE----ELKIAHIHL-KEHQETIDELRRS-------VSEKTAQIINTQDLEKSHTKL 1278

Query: 590  VLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKN--------HYMARIVELTSQLQLADS 641
                                E+P +   ++L+ N          M  +  LT Q    DS
Sbjct: 1279 ------------------QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS 1320

Query: 642  KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD 701
             ++      R   +RL L EK +E+  EE+K    ++++ +D L T K + E +   + +
Sbjct: 1321 TTL-----ARIEMERLRLNEKFQES-QEEIK----SLTKERDNLKTIKEALEVKHDQLKE 1370

Query: 702  HLCSMNETLSK----QREEIDTLKMSSKGN 727
            H+    ETL+K    Q ++  +L M  K N
Sbjct: 1371 HI---RETLAKIQESQSKQEQSLNMKEKDN 1397



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 100/424 (23%), Positives = 180/424 (42%), Gaps = 57/424 (13%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            KD +L +++ EM       L L+KR++   DE+          ++  E     S + K  
Sbjct: 1412 KDSALLRIEIEM-------LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKEN 1464

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAA----QHQAVVDGLTR 117
              E + K +E  E L +      EQ + +  ELR  L+  ETE +    Q +A+ D L  
Sbjct: 1465 IKEIVAKHLETEEELKVAHCCLKEQEETIN-ELRVNLSEKETEISTIQKQLEAINDKLQN 1523

Query: 118  KYMETIEKLQ--NDKAKLEVKSQTLE-KEAKECRLRTEECQLQLKTLHEDLSGRLEESLS 174
            K  E  EK +  N K   EV+ +  E K+ KE R   +     +++   +L+ RL+ES  
Sbjct: 1524 KIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES-- 1581

Query: 175  IINEKVPFNDTKYSQYNALNVPLHNRRHQLK--MRDIAGQALAFVQDLVTALLNFHTYTE 232
               E++     +  +   +   L   R QLK   ++I  + +   Q+     L      E
Sbjct: 1582 --QEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK-MKESQEKEYQFLKMTAVNE 1638

Query: 233  QRIQIFPVDSA----------IDTISPLNQKFSQYLHENASY----------VRPLEEGM 272
             + ++  ++            ++ I   N + +Q LHEN             +R +EE +
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698

Query: 273  L----HLFESITEDTVTVLETTVKLKTFSEHLTSY---ICFLRKIL---PYQLKSLEEEC 322
                  L E++ E     LE   +LK    HL  +   I  LR I+     ++ +++++ 
Sbjct: 1699 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1758

Query: 323  ESSLCTSALRARNLELSQDMK-KMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNV 381
            E S    AL+A++L++ ++++     + E+ +T   L  + S + D L  +N    L N 
Sbjct: 1759 EHS--NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL--SNMQKDLENS 1814

Query: 382  GAAL 385
             A L
Sbjct: 1815 NAKL 1818



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 83/368 (22%), Positives = 153/368 (41%), Gaps = 59/368 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLA---KRVELLQDELALSEPRGKKNKKSGESSSQLS---- 55
            + S  KLQ+++  L     QL    K V   Q +++  E   K+ K    + S+L     
Sbjct: 1812 ENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENL 1871

Query: 56   ----------QEQKSVFDE-DLQKKIEENERLHI-QFFEADEQHKHVEAELRSRLATLET 103
                      +E KSV  E D  +++EE  +L   Q  E+ ++ K  + E++  L T   
Sbjct: 1872 NLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM 1931

Query: 104  EAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHE 163
             + +H+  VD L  K  E   ++ + +  L+     L+K+ +E  L+ +E QL       
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQE--LQKKELQLL------ 1983

Query: 164  DLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTA 223
                R++E +++ ++K+   +    Q+ A N         L M+ +        + L  +
Sbjct: 1984 ----RVKEDVNMSHKKINEMEQLKKQFEAQN---------LSMQSVRMDNFQLTKKLHES 2030

Query: 224  LLNFHTYTEQRIQIFPV--------DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHL 275
            L       ++R ++  +        D  I T+  +  +  Q  H+     R L +G  HL
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQN-HQVKPEKRLLSDGQQHL 2089

Query: 276  FESITEDTVTVLETTVKLKTFSEHLTSYICF------LRKILPYQLKSLEEECESSLCTS 329
             ES+ E    + E    LK +SE    Y C       L K + +Q K L    +++L   
Sbjct: 2090 TESLREKCSRIKEL---LKRYSEMDDHYECLNRLSLDLEKEIEFQ-KELSMRVKANLSLP 2145

Query: 330  ALRARNLE 337
             L+ +++E
Sbjct: 2146 YLQTKHIE 2153



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 137/745 (18%), Positives = 291/745 (39%), Gaps = 102/745 (13%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K+  ++KLQ+ +DS    N+    +++L     ++ +P+  K       +  L  +++S 
Sbjct: 587  KEDQIKKLQEYIDSQKLENI----KMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA 642

Query: 62   F----DEDLQKKIEENERLH------IQFFEAD-EQHKHVEAELRSRLATLETEAAQHQA 110
            F    + +L++K++E    +      IQ +++  E  K ++ +L   L +   E  +  +
Sbjct: 643  FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702

Query: 111  VVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQL---------QLKTL 161
            ++DG   K +    +L+    K+    + L KE +E     EE  L         +++ L
Sbjct: 703  LIDGKVPKDLLCNLELE---GKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759

Query: 162  HEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLV 221
             +++  + EE   I +EK    D  +S+       +H       + +  G+      DL 
Sbjct: 760  RKEIQDKSEELHIITSEK----DKLFSEV------VHKESRVQGLLEEIGKT---KDDLA 806

Query: 222  TALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE 281
            T   N+ + T+Q  Q F             QK+   L EN               E + +
Sbjct: 807  TTQSNYKS-TDQEFQNFKT-----LHMDFEQKYKMVLEEN---------------ERMNQ 845

Query: 282  DTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC-ESSLCTSALRARNLELSQ 340
            + V + +   K  +    L + + +  + L  + + ++E   E       L  R+  L  
Sbjct: 846  EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905

Query: 341  DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYS 400
              ++ T + EKLQ  +  +   + E D L +   S  +            +  DI    +
Sbjct: 906  VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER--------DQLKSDIHDTVN 957

Query: 401  QKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAAS 460
                 + +L  A + L    + I            KI+   S NL           +  +
Sbjct: 958  MNIDTQEQLRNALESLKQHQETI-------NTLKSKISEEVSRNLHM---------EENT 1001

Query: 461  GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQ 520
            G       + M+   KK     K+  + L   V   E +  +R + S  + +  L Q ++
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKN-TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060

Query: 521  QSLEKISKLEQE-KEHWML------EAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
              + +  +L+ + KE+  +      E +L   +L+K+ + +A + KN    +   L++  
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE-KNHAIKKEGELSRTC 1119

Query: 574  AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 633
              ++    + +  ++ + E  Q    +         ++ ++E+ ++ +KN  +      T
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179

Query: 634  SQLQLADSKSVHFYAECRALSK-RLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSY 692
             +L+LA   + + Y E ++++K R  L E  K   TE       ++     E+  T    
Sbjct: 1180 ERLELAQKLNEN-YEEVKSITKERKVLKELQKSFETER-----DHLRGYIREIEATGLQT 1233

Query: 693  EDQLSMMSDHLCSMNETLSKQREEI 717
            +++L +   HL    ET+ + R  +
Sbjct: 1234 KEELKIAHIHLKEHQETIDELRRSV 1258



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 161/740 (21%), Positives = 299/740 (40%), Gaps = 118/740 (15%)

Query: 22   QLAKRVELLQDELALSEPRGKKNKKSGESSSQLS--QEQKSVFDEDLQKKIE-ENERLHI 78
            +L + + +L +E  L  P  K+  ++ E+ ++L    EQ +  D     +IE E  RL+ 
Sbjct: 1277 KLQEEIPVLHEEQELL-PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335

Query: 79   QFFEADEQHKHVEAELRSRLATL-ETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKS 137
            +F E+ E+ K +  E R  L T+ E    +H    D L     ET+ K+Q  ++K E   
Sbjct: 1336 KFQESQEEIKSLTKE-RDNLKTIKEALEVKH----DQLKEHIRETLAKIQESQSKQEQSL 1390

Query: 138  QTLEKEAKECRLRTEECQ--------LQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQ 189
               EK+ +  ++ +E  Q        L+++     LS RL+ES    ++++     +   
Sbjct: 1391 NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES----HDEMKSVAKEKDD 1446

Query: 190  YNALNVPLHNRRHQLK--MRDIAGQALAFVQDLVTALL----NFHTYTEQRIQIFPVDSA 243
               L   L +   QLK  +++I  + L   ++L  A         T  E R+ +   ++ 
Sbjct: 1447 LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506

Query: 244  IDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 303
            I TI    +  +  L      +   EE      + I+E    V E   +LK F EH    
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEEQF--NIKQISE----VQEKVNELKQFKEH---- 1556

Query: 304  ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPS 363
                RK     L+S+E +         L  R  E  ++++ M    E+++     L +  
Sbjct: 1557 ----RKAKDSALQSIESK------MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606

Query: 364  TEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQK--AAIEH-ELPTATQKLITTN 420
             +    L+ N   ++  +  +    +  +K  + + +Q+    IEH +    TQKL   N
Sbjct: 1607 DQ----LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662

Query: 421  DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480
              I +  + LT            NL+   +                S E  L+ ++    
Sbjct: 1663 --IETENIRLT-------QILHENLEEMRSVTKERDDLR-------SVEETLKVERD--Q 1704

Query: 481  YMKSLRKPLLESVPYEEALANRRI-LLSSTESREGLAQQVQQSLEKISKLEQEKEHW--M 537
              ++LR+ +   +  +E L    + L    E+ + L   V +   +IS ++++ EH    
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764

Query: 538  LEAQLAKIKLE--------KENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKA 589
            L+AQ  KI+ E        KE Q   DKL+   S +   L+     + N+  + +   + 
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824

Query: 590  VLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAE 649
            +         +      +  +V ++E  +  IK+  +       S+L++           
Sbjct: 1825 LKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT-----LSKLEI----------- 1868

Query: 650  CRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLC-SMNE 708
                 + L LA+K  E L EEMK    ++ + +D L    R  E+ L +  D L  S+ E
Sbjct: 1869 -----ENLNLAQKLHENL-EEMK----SVMKERDNL----RRVEETLKLERDQLKESLQE 1914

Query: 709  TLSKQ---REEIDTLKMSSK 725
            T ++    ++E+ T +M SK
Sbjct: 1915 TKARDLEIQQELKTARMLSK 1934



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 142/745 (19%), Positives = 279/745 (37%), Gaps = 129/745 (17%)

Query: 32   DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIE----ENERLHIQFFEADEQH 87
            DE   SE     N     S  + +   K +  E+++ ++     + + L + + +   + 
Sbjct: 462  DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK 521

Query: 88   KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 147
            + +E +L+ +    E EA + +   D    + +  I  L+N     EV +Q LE E    
Sbjct: 522  EEMELKLKEKNDLDEFEALERKTKKDQ-EMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580

Query: 148  RLRTEECQLQLKTLHEDLSG------RLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR 201
                 E + Q+K L E +        +++ S S+ + + P    K + ++A  V L  +R
Sbjct: 581  VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP-KQMKQTLFDAETVALDAKR 639

Query: 202  HQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHEN 261
                +R    +    +++L T      TY +    I              Q +   L   
Sbjct: 640  ESAFLRSENLELKEKMKELAT------TYKQMENDI--------------QLYQSQLEAK 679

Query: 262  ASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEE 321
                  LE+ +   F  IT+ T  +     K    +  L   I  L+K L  +++  E  
Sbjct: 680  KKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEAL 739

Query: 322  CESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL------RTNYS 375
             E  +  S L++   E+ +  K++    E+L        + ++E D L        +   
Sbjct: 740  REEVILLSELKSLPSEVERLRKEIQDKSEELH-------IITSEKDKLFSEVVHKESRVQ 792

Query: 376  SVLTNVGAA---LHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTN 432
             +L  +G     L       K   + +     +  +     + ++  N+ +   +V L+ 
Sbjct: 793  GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852

Query: 433  GAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLES 492
             A K    F ++L      LSY  +              LQ K       + +++ L E 
Sbjct: 853  EAQK----FDSSLGALKTELSYKTQE-------------LQEK------TREVQERLNEM 889

Query: 493  VPYEEALANRRILLSSTESREGL-AQQVQQSLEKISKLEQEK-------EHWMLEAQLAK 544
               +E L NR   L + E  + L  +++QQ+LE++  L QEK       E   +E    K
Sbjct: 890  EQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK 949

Query: 545  ----------IKLEKENQRIADKLK------NTGSAQLVGLAQENAAVSNTAGQ--DEAT 586
                      I  +++ +   + LK      NT  +++      N  +    G+  DE  
Sbjct: 950  SDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQ 1009

Query: 587  AKAV-LEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVH 645
             K V ++  Q      T T T+     DV+  E + +   +  +++  ++LQ        
Sbjct: 1010 QKMVGIDKKQDLEAKNTQTLTA-----DVKDNEIIEQQRKIFSLIQEKNELQ-------- 1056

Query: 646  FYAECRALSKRLALAEKSKEALTEEMKLASQNISRL---------QDELTTTKRSY---- 692
                 + L   +A  E+ K  L E +++  +N   L         Q E+   ++++    
Sbjct: 1057 -----QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKK 1111

Query: 693  EDQLSMMSDHLCSMNETLSKQREEI 717
            E +LS   D L  + E L ++ +++
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEKSQQL 1136



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 65/292 (22%), Positives = 111/292 (38%), Gaps = 31/292 (10%)

Query: 465 PLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESR----EGLAQQVQ 520
           P    C L+ + K     K L K + E+    EAL    ILLS  +S     E L +++Q
Sbjct: 709 PKDLLCNLELEGKITDLQKELNKEVEEN----EALREEVILLSELKSLPSEVERLRKEIQ 764

Query: 521 QSLEKISKLEQEKEHWMLEAQLAKIKLE---KENQRIADKLKNTGSAQLVGLAQENAAVS 577
              E++  +  EK+    E    + +++   +E  +  D L  T S       QE     
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS-NYKSTDQEFQNFK 823

Query: 578 NTAGQDEATAKAVLEPIQST---------------SLIGTLTRTSDSEVPDVESREDLIK 622
                 E   K VLE  +                 S +G L      +  +++ +   ++
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883

Query: 623 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 682
              +  + +L  QL+  DS       E   ++++L    +  + LT+E     Q    LQ
Sbjct: 884 ER-LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942

Query: 683 DELTTTKRSYEDQLSMMSD---HLCSMNETLSKQREEIDTLKMSSKGNSKKN 731
            E    K    D ++M  D    L +  E+L + +E I+TLK        +N
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 69/315 (21%), Positives = 123/315 (39%), Gaps = 56/315 (17%)

Query: 9    LQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQK 68
            L+ E D L     +   R    Q+EL +     K+++++ +    +  E+ +    ++QK
Sbjct: 1698 LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS-NMQK 1756

Query: 69   KIEE-NERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ 127
             +E  N+ L  Q  +  E+ +     L+ +  T++    + + +V   T K     + L+
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETID----KLRGIVSEKTDKLSNMQKDLE 1812

Query: 128  NDKAKLEVKSQ----------TLEKEAKECRLRTEECQLQLK------------------ 159
            N  AKL+ K Q          TL+K+  E + +  E + QLK                  
Sbjct: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENL 1871

Query: 160  TLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK--MRDIAGQALAFV 217
             L + L   LEE  S++ E+             +   L   R QLK  +++   + L   
Sbjct: 1872 NLAQKLHENLEEMKSVMKER--------DNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923

Query: 218  QDLVTA--LLNFHTYT---------EQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVR 266
            Q+L TA  L   H  T         E+ IQI  +   +D      QK  Q L +    + 
Sbjct: 1924 QELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983

Query: 267  PLEEGMLHLFESITE 281
             ++E +    + I E
Sbjct: 1984 RVKEDVNMSHKKINE 1998


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 158/807 (19%), Positives = 308/807 (38%), Gaps = 133/807 (16%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKS-GESSSQLSQEQKSVF 62
            Q L+KL+  ++ LT +N  L +   LL+ E   ++   K N++S  + + Q +  QK + 
Sbjct: 288  QELQKLKSSVNELTQKNQTLTEN--LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345

Query: 63   DEDLQKKIEENE----RLHIQFFEADE--------------QHKHVEAELRSRLATLETE 104
             + LQ ++  +E    R+H++  E  E              +++H++AE + +L     E
Sbjct: 346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK-QLQQQREE 404

Query: 105  AAQH----QAVVDGLTRKYMETIEKL---------------------QNDKAKLEVKSQT 139
              QH    Q+ ++ L  K +ET  +L                     +   A L++K   
Sbjct: 405  KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464

Query: 140  LEKEAKECRLRTEECQLQL----------KTLHEDLSGRLEES---LSIINEKVPFNDTK 186
            LE++ KE    + E Q QL          + L +  + +L E+   L  +  ++   D K
Sbjct: 465  LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524

Query: 187  YSQYNAL------NVPL-HNRRHQLKMRDIAGQALAFVQDLVTALLNF-----HTYTEQR 234
                 AL      N+ L    R  L  +  AG+         TA+LN      HT  EQ 
Sbjct: 525  IQNLEALLQKSKENISLLEKEREDLYAKIQAGEG-------ETAVLNQLQEKNHTLQEQV 577

Query: 235  IQIFP-VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKL 293
             Q+   + +  ++     +     + E  +++R  ++ +L L  S+ E    + E+  K+
Sbjct: 578  TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637

Query: 294  KTFSEHL---TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFE 350
                  +   T  +         Q   L+   +++   +AL+ +  EL++   ++  V  
Sbjct: 638  SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA--QNALQDKQQELNKITTQLDQVTA 695

Query: 351  KLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELP 410
            KLQ                 +  + S L +           +K+  + Y        EL 
Sbjct: 696  KLQD----------------KQEHCSQLESH----------LKEYKEKYLSLEQKTEELE 729

Query: 411  TATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC 470
               +KL   +  + +S         +     + +L+     LS   +     +S  S   
Sbjct: 730  GQIKKLEADSLEVKASKEQALQDLQQQRQL-NTDLELRATELSKQLEMEKEIVS--STRL 786

Query: 471  MLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTES--REGLAQQVQQSLEKISK 528
             LQ K +A   ++S+++ L +    ++ L      LS       E L  ++Q ++ ++ K
Sbjct: 787  DLQKKSEA---LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843

Query: 529  LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAK 588
            ++ EKE  M E    K KL K    ++D LKN+ S       +EN          E T K
Sbjct: 844  VKMEKEALMTELSTVKDKLSK----VSDSLKNSKSE----FEKENQKGKAAILDLEKTCK 895

Query: 589  AVLEPIQSTSLIGTLTRTSDSEVPDVESRE-----DLIKNHYMARIVELTSQLQLADSKS 643
             +   +Q   +  TL    + +    + +E      L  N    ++++  + L+  + + 
Sbjct: 896  ELKHQLQ-VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEE 954

Query: 644  VHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHL 703
                     L +     +K  EAL  E+K+A    + L+++L         +L+   + +
Sbjct: 955  QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014

Query: 704  CSMNETLSKQREEIDTLKMSSKGNSKK 730
              +     K +E    L+    G   +
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESE 1041



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 150/795 (18%), Positives = 300/795 (37%), Gaps = 83/795 (10%)

Query: 6   LRKLQQEMDSLTFRNLQLAKRVELLQDELA--LSEPRGKKNKKSGESSSQLSQEQKSV-F 62
           L+ L+Q+++     N  + +  +L + + A   +E    K+K   E S + + EQK    
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196

Query: 63  DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
            E+L K+    + L  +      Q   +E      +A L+ E  Q Q ++D +T +    
Sbjct: 197 TEELNKEATVIQDLKTELL----QRPGIED-----VAVLKKELVQVQTLMDNMTLERERE 247

Query: 123 IEKLQNDKAKLEVKSQTLEKEAKECRLRTE------ECQLQLKTLHEDLS--GRLEESLS 174
            EKL+++  KL+  SQ    EA   +LR+E      E  + ++ L +  S    L +   
Sbjct: 248 SEKLKDECKKLQ--SQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305

Query: 175 IINEKVPFNDTKYS----QYNALNVPLHNRRHQLKMRDIAGQAL-AFVQDLVTALLNFHT 229
            + E +   +  Y+    ++N  +V   N +  L  +D+  Q L + +    T+L   H 
Sbjct: 306 TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365

Query: 230 YTEQ--------RIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE 281
              +        + ++  V++    +    ++  Q   E   +   L+  +  L   + E
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425

Query: 282 DTVTVLETTVKLKTFSEHLTSYICFLRK----ILPYQLKSLEEECESSLCTSALRARNLE 337
               + E   +LK     L+S     ++     L  +L  LEE+ +  +  S      L+
Sbjct: 426 TERQLGEAHGRLKE-QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484

Query: 338 LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRT--NYSSVLTNVGAALHGFHDVMKDI 395
            ++   +     +  Q+  A L     + + +LR   +    + N+ A L    + +  +
Sbjct: 485 KTKQQHQEQQALQ--QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542

Query: 396 SKH----YSQKAAIEHELPTATQKLITTNDCILSSVVALT---NGAGKIASFFSNNLDYF 448
            K     Y++  A E E     Q L   N  +   V  LT       +       NL   
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601

Query: 449 IASLSYGPKAASGFISPLSA-----ECMLQYKKKAAAYMKSLRKPLLESVPYEEA--LAN 501
           +       +AA   +  L          L   K+  + +    K   E +   EA   A 
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661

Query: 502 RRILLSSTESREGLAQQVQQSLEKI--------SKLEQEKEHW-MLEAQLAKIK-----L 547
           R  L +  ++ +   Q  QQ L KI        +KL+ ++EH   LE+ L + K     L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721

Query: 548 EKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTS 607
           E++ + +  ++K   +  L   A +  A+ +   Q +      L   + +  +       
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781

Query: 608 DSEVPDVESRED--------LIKNHYMARIVELTSQLQLADSKSVHFYAECRALS--KRL 657
            S   D++ + +        L K     +I++   +    ++K  H     R  +    L
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTEL 841

Query: 658 ALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEI 717
              +  KEAL  E+      +S++ D L  +K  +E +       +  + +T  + + ++
Sbjct: 842 QKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL 901

Query: 718 DTLKMSSKGNSKKNK 732
                ++    K+ K
Sbjct: 902 QVQMENTLKEQKELK 916



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 48/210 (22%), Positives = 94/210 (44%), Gaps = 22/210 (10%)

Query: 2   KDQSLRKLQQEMD---SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQ 58
           K+Q+L+ LQQ+      L  R  +L+K++E+               +K   SS++L  ++
Sbjct: 746 KEQALQDLQQQRQLNTDLELRATELSKQLEM---------------EKEIVSSTRLDLQK 790

Query: 59  KSVFDEDLQKKI---EENERLHIQFFEADEQHKHVE-AELRSRLATLETEAAQHQAVVDG 114
           KS   E +++K+   EE +++  Q FE   Q   ++  EL +R+ T  TE  + +   + 
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850

Query: 115 LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLS 174
           L  +     +KL      L+      EKE ++ +    + +   K L   L  ++E +L 
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLK 910

Query: 175 IINEKVPFNDTKYSQYNALNVPLHNRRHQL 204
              E     + +    + L + L++ + QL
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQL 940



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 141/748 (18%), Positives = 288/748 (38%), Gaps = 87/748 (11%)

Query: 53  QLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRS---RLATLETEAAQHQ 109
           Q S +++  + E+L+K++E+ + L  Q  + D       AEL+S   +L   +TE    +
Sbjct: 96  QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155

Query: 110 AVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRL 169
            + D   +K  +   ++ + K+K + +    E   ++    TEE   +  T+ +DL   L
Sbjct: 156 QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE-ATVIQDLKTEL 214

Query: 170 EESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ---ALAFVQDLVTALLN 226
            +   I +  V   +    Q    N+ L   R   K++D   +     A  +  ++ L +
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274

Query: 227 FHTYTEQRIQIF-----PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE 281
                 Q + ++      + S+++ ++  NQ  ++ L +       LEE   H  ES+++
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE--KHNEESVSK 332

Query: 282 DTV--TVLETTVKLKTFSEHLTSYICFLRKIL-------PYQLKSLEEECESSLCTSALR 332
             +  T+ +  +  +     L++    L +I            K  EE  E       L+
Sbjct: 333 KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLK 392

Query: 333 ARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVM 392
           A   +L Q  ++      +LQ+ I  L     E +  L   +  +      +     D  
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452

Query: 393 KDISKHYSQKAAIEHEL------PTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLD 446
           + ++    + + +E +L       T  Q  +           AL            N+L+
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512

Query: 447 YFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILL 506
             +  +    +         + E +LQ  K+  + ++  R+ L   +   E      +L 
Sbjct: 513 QVLRQIGDKDQKIQ------NLEALLQKSKENISLLEKEREDLYAKIQAGE--GETAVLN 564

Query: 507 SSTESREGLAQQVQQSLEKIS------KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKN 560
              E    L +QV Q  EK+       K  QE  H  ++ Q A ++  ++     +   N
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624

Query: 561 TGSAQLVGLAQE----------------NAAVSNTAGQDEA-----TAKAVLEPIQ---- 595
             ++QL    ++                +A  + TA + +      TA+  L+  Q    
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684

Query: 596 --STSLIGTLTRTSDSE--VPDVESREDLIKNHYMA---RIVELTSQLQLADSKSVHFYA 648
             +T L     +  D +     +ES     K  Y++   +  EL  Q++  ++ S+   A
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744

Query: 649 ECRALSKRLALAE-KSKEALTEEMKLASQNISR---LQDELTTTKRSYEDQLSMMSDHLC 704
                SK  AL + + +  L  +++L +  +S+   ++ E+ ++ R     L   S+ L 
Sbjct: 745 -----SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL---DLQKKSEALE 796

Query: 705 SMNETLSKQREEIDTLKMSSKGNSKKNK 732
           S+ + L+KQ EE   LK   +  S++ K
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETK 824



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 44/175 (25%), Positives = 83/175 (47%), Gaps = 10/175 (5%)

Query: 8    KLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQ--EQKSVFDED 65
            K   E DS   +  QL +R + LQD   + + +  K K+     S+L++  E K   +++
Sbjct: 1084 KATLEQDSAK-KEQQLQERCKALQD---IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139

Query: 66   LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 125
            + K  EE +   ++  +     K  +  L  +   L+ +A   +A V+    K  + I K
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE--QEKRNQQILK 1197

Query: 126  LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
             Q  K + E+K + +EKEAK      +E ++ +K  HE+   +L   ++ +NE +
Sbjct: 1198 DQVKKEEEELKKEFIEKEAK-LHSEIKEKEVGMKK-HEENEAKLTMQITALNENL 1250



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 31/179 (17%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKN--KKSGESSSQLSQEQKSV 61
            Q   +LQ + DSL     Q  +  ++L+D++   E   KK   +K  +  S++ +++  +
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229

Query: 62   FDEDLQKKIEENE-RLHIQFFEADEQHKHVEAE-----------------LRSRLATLET 103
                  KK EENE +L +Q    +E    V+ E                 LR  +A LE 
Sbjct: 1230 ------KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA 1283

Query: 104  EAAQHQAVVDGLTRKYME---TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLK 159
                +Q     L  + ++    IEKLQ    +L+ K        +E  L  E   LQ+K
Sbjct: 1284 TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE--LGRENQSLQIK 1340


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 151/754 (20%), Positives = 290/754 (38%), Gaps = 77/754 (10%)

Query: 3    DQSLRKLQQEMDSLTFR-------NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLS 55
            D+ L+K + EM  L  +        +QL K+++ LQ  +   E    +  ++  +S   +
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE----EEIEAERASRAKA 1136

Query: 56   QEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 115
            ++Q+S    +L++  E  E          E +K  EAE +     LE    QH+A    L
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             +K+ +++ +L      L+   Q LEKE  E ++  ++    ++T+ +   G LE+    
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK-AKGNLEKMCRA 1255

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLN--FHTYTEQ 233
            + +++    TK  +   L   L  +R +L+            +D + + L+     +T+Q
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315

Query: 234  RIQI-FPVDSAIDTISPLNQKFSQYLHE---NASYVRPLEEGMLHLFESITEDTVTVLET 289
              ++   ++  I   S L        H+           +E    L  ++++    V + 
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375

Query: 290  TVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVF 349
              K +T +   T  +   +K L  +L+  EE  E      A+ A+   L +  +++    
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE------AVNAKCASLEKTKQRLQNEV 1429

Query: 350  EKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHEL 409
            E L   +              RTN +       AAL         I   + QK    H  
Sbjct: 1430 EDLMIDVE-------------RTNAAC------AALDKKQRNFDKILAEWKQKCEETHAE 1470

Query: 410  PTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAE 469
              A+QK             +L+    KI + +  +LD  + +L    K     IS L+ +
Sbjct: 1471 LEASQK----------ESRSLSTELFKIKNAYEESLDQ-LETLKRENKNLQQEISDLTEQ 1519

Query: 470  CM--------LQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ 521
                      L+  KK     KS  +  LE           +IL    E  +  ++  ++
Sbjct: 1520 IAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1579

Query: 522  SLEKISKLEQEKEHWMLEAQLAKIKLEKE----NQRIADKLKNTGSAQLVGLAQENA-AV 576
              EK  +++Q K + +   +  +  L+ E    N  I  K K  G    + +   +A  +
Sbjct: 1580 IAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM 1639

Query: 577  SNTAGQDEATAKAVLEPIQSTSLIGTLTRTSD--SEVPDVESREDLIKNHYMARIVELTS 634
            +  A ++    +A+L+  Q   L   L    D   ++  VE R +L++    A I EL +
Sbjct: 1640 AAEALRNYRNTQAILKDTQ-LHLDDALRSQEDLKEQLAMVERRANLLQ----AEIEELRA 1694

Query: 635  QLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRS 691
             L+  +        E    S+R+ L      +L    K    +IS++Q   +++    R+
Sbjct: 1695 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARN 1754

Query: 692  YEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
             E++          M E L K+++    L+   K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 145/757 (19%), Positives = 292/757 (38%), Gaps = 113/757 (14%)

Query: 32   DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLH------IQFFEADE 85
            D+L L+  + +K K + E+  +   E+ +  DE + K  +E + L       +   +A+E
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1018

Query: 86   QHKH----VEAELRSRLATLETEAAQHQAV----------VDGLTRKYMETIEKLQNDKA 131
               +     + +L  ++  LE    Q + +          ++G  +   E+   ++NDK 
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQ 1078

Query: 132  KLEVK---------------------SQTLEKEAKECRLRTEECQLQLKTLH-------- 162
            +L+ K                        L+K+ KE + R EE + +++           
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138

Query: 163  ---------EDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR--RHQLKMRDIAG 211
                     E++S RLEE+    + ++  N  + +++  +   L     +H+     +  
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198

Query: 212  QALAFVQDLVTALLNFHTY--------TEQRIQIFPVDSAIDTISPLN---QKFSQYLHE 260
            +    V +L   + N            +E +++I  + S ++T+S      +K  + L +
Sbjct: 1199 KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED 1258

Query: 261  NASYVRPLEEGMLHLFESITEDTVTV-LETTVKLKTFSEH--LTSYICFLRKILPYQLKS 317
              S ++  EE    L   +T     +  E+    +   E   L S +   ++    Q++ 
Sbjct: 1259 QLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318

Query: 318  LEEECESSLCTSALRARNLELSQ-DMKKMTAVFEKLQTYIALLALPSTEPDGLL---RTN 373
            L+ + E  +   +  A  L+ S+ D   +   +E+ Q   A L    ++ +  +   RT 
Sbjct: 1319 LKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK 1378

Query: 374  YSS----VLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVA 429
            Y +        +  A       ++D  +H     A    L    Q+L    + ++   V 
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMID-VE 1437

Query: 430  LTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAE---CMLQYKKKAAAYMKSLR 486
             TN A         N D  +A      +     +     E      +  K   AY +SL 
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497

Query: 487  KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISK-LEQEKEHWMLEAQLAKI 545
            +  LE++  E     + I   + +  EG  +++ + LEKI K +EQEK       + A+ 
Sbjct: 1498 Q--LETLKRENKNLQQEISDLTEQIAEG-GKRIHE-LEKIKKQVEQEKSELQAALEEAEA 1553

Query: 546  KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTR 605
             LE E  +I          QL     ++      A +DE   +     I+   ++ ++  
Sbjct: 1554 SLEHEEGKIL-------RIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIR---IVESMQS 1603

Query: 606  TSDSEVPDVESREDLI--KNHYMARIVELTSQLQLAD---SKSVHFYAECRALSKRLAL- 659
            T D+E   + SR D I  K      + E+  QL  A+   ++++  Y   +A+ K   L 
Sbjct: 1604 TLDAE---IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLH 1660

Query: 660  ---AEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 693
               A +S+E L E++ +  +  + LQ E+   + + E
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 51/244 (20%), Positives = 92/244 (37%), Gaps = 21/244 (8%)

Query: 487  KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSL-EKISKLEQEKEHWMLEAQLAKI 545
            KPLL+S   E+ +AN +     T+      +  ++ L EK+  L QEK    L+ Q    
Sbjct: 841  KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900

Query: 546  KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTR 605
             L    +R    +K                   T  Q EA  K V E  +    I     
Sbjct: 901  SLADAEERCDQLIK-------------------TKIQLEAKIKEVTERAEDEEEINAELT 941

Query: 606  TSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKE 665
                ++ D  S      +     + ++  +    ++K  +   E   L + +A   K K+
Sbjct: 942  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001

Query: 666  ALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
            AL E  +    ++   +D++ T  ++ + +L    D L    E   K R +++  K   +
Sbjct: 1002 ALQEAHQQTLDDLQAEEDKVNTLTKA-KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060

Query: 726  GNSK 729
            G+ K
Sbjct: 1061 GDLK 1064


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 160/780 (20%), Positives = 298/780 (38%), Gaps = 129/780 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV- 61
            D+ L+K   E+++L  R          ++DE AL     KK K+      +L +E ++  
Sbjct: 1077 DERLKKKDFELNALNAR----------IEDEQALGSQLQKKLKELQARIEELEEELEAER 1126

Query: 62   --------FDEDLQKKIEE-NERLHIQFFEAD---EQHKHVEAELRSRLATLETEAAQHQ 109
                       DL +++EE +ERL           E +K  EAE +     LE    QH+
Sbjct: 1127 TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186

Query: 110  AVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRL 169
            A    L +K+ +++ +L      L+   Q LEKE  E +L             +D++  +
Sbjct: 1187 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL-----------DDVTSNM 1235

Query: 170  EESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHT 229
            E+   II  K        +  + +N          + R  A +    V DL         
Sbjct: 1236 EQ---IIKAKANLEKMCRTLEDQMN----------EHRSKAEETQRSVNDL--------- 1273

Query: 230  YTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLET 289
             T QR +          +   N + S+ L E  + +  L  G L   + + ED    LE 
Sbjct: 1274 -TSQRAK----------LQTENGELSRQLDEKEALISQLTRGKLTYTQQL-EDLKRQLEE 1321

Query: 290  TVKLKTFSEHL---TSYICFLRKILPYQLKSLEEECESSL-CTSALRARNLELSQ----- 340
             VK K    H      + C L +      +  EEE E+       L   N E++Q     
Sbjct: 1322 EVKAKNALAHALQSARHDCDLLR------EQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

Query: 341  --DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKH 398
              D  + T   E+ +  +A     + E    +    SS+        +   D+M D+ + 
Sbjct: 1376 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS 1435

Query: 399  YSQKAAIEHE-------LPTATQKLITTNDCILSS---VVALTNGAGKIASFFSNNLDYF 448
             +  AA++ +       L    QK   +   + SS     +L+    K+ + +  +L++ 
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH- 1494

Query: 449  IASLSYGPKAASGFISPLSAEC---------MLQYKKKAAAYMKSLRKPLLE---SVPYE 496
            + +     K     IS L+ +          + + +K+  A    L+  L E   S+ +E
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554

Query: 497  EALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKE----NQ 552
            E     +IL +  E  +  A+  ++  EK  ++EQ K + +      +  L+ E    N+
Sbjct: 1555 EG----KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610

Query: 553  RIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL-IGTLTRTSD--- 608
             +  K K  G    + +   +A  +  A + +   K++   ++ T + +    R +D   
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668

Query: 609  SEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALT 668
              +  VE R +L++    A + EL + ++  +        E    S+R+ L      +L 
Sbjct: 1669 ENIAIVERRNNLLQ----AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724

Query: 669  EEMKLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
             + K    ++S+LQ   +E     R+ E++          M E L K+++    L+   K
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1784



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 164/794 (20%), Positives = 311/794 (39%), Gaps = 105/794 (13%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQL-----SQ 56
            +D     LQ E  +   R        EL +    L   + K  K+  E   +L     + 
Sbjct: 1176 RDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235

Query: 57   EQKSVFDEDLQKKIEENE-RLHIQFFEADEQHKHVEAELRSRLATLETEAAQ-------H 108
            EQ      +L+K     E +++    +A+E  + V  +L S+ A L+TE  +        
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-DLTSQRAKLQTENGELSRQLDEK 1294

Query: 109  QAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGR 168
            +A++  LTR  +   ++L++ K +LE + +     A   +    +C L  +   E+   +
Sbjct: 1295 EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK 1354

Query: 169  --LEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLN 226
              L+  LS  N +V    TKY + +A+         + K+     +A   V + V A  +
Sbjct: 1355 AELQRVLSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEEAV-EAVNAKCS 1412

Query: 227  FHTYTEQRIQIFPVDSAID------TISPLNQKFSQYLHENASYVRPLEEGMLHLFESIT 280
                T+ R+Q    D  +D        + L++K   +    A + +  EE    L ES  
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL-ESSQ 1471

Query: 281  EDTVTVLETTVKLK-TFSEHLTSYICFLR--KILPYQLKSLEEECESSLCTSALRARNLE 337
            ++  ++     KLK  + E L     F R  K L  ++  L E+  SS  T        E
Sbjct: 1472 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH------E 1525

Query: 338  LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK 397
            L +  K++ A  EK++   AL      E +  L      +L     A   F+ +  +I +
Sbjct: 1526 LEKVRKQLEA--EKMELQSAL-----EEAEASLEHEEGKIL----RAQLEFNQIKAEIER 1574

Query: 398  HYSQKAAIEHELPTATQKLITTNDCILSSVVALT---NGAGKIASFFSNNLDYFIASLSY 454
              ++K   + E+  A +  +   D + +S+ A T   N A ++      +L+     LS+
Sbjct: 1575 KLAEK---DEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631

Query: 455  GPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREG 514
              +        ++AE   Q  K   + +K  +  L ++V   + L      ++  E R  
Sbjct: 1632 ANR--------MAAEAQKQV-KSLQSLLKDTQIQLDDAVRANDDLKEN---IAIVERRNN 1679

Query: 515  LAQ----QVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLA 570
            L Q    +++  +E+  +  +  E  ++E       L  +N  + ++ K    A L  L 
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM-DADLSQLQ 1738

Query: 571  QE-NAAVSNTAGQDEATAKAV---------LEPIQSTSL-IGTLTRTSDSEVPDVESRED 619
             E   AV      +E   KA+         L+  Q TS  +  + +  +  + D++ R D
Sbjct: 1739 TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798

Query: 620  LIKNHYM-----------ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALT 668
              +   +           AR+ EL ++L+    ++       R   +R+       + LT
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRI-------KELT 1851

Query: 669  EEMKLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK---- 721
             + +   +N+ RLQ   D+L    ++Y+ Q     +   +      K + E+D  +    
Sbjct: 1852 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911

Query: 722  -MSSKGNSKKNKSR 734
               S+ N  + KSR
Sbjct: 1912 IAESQVNKLRAKSR 1925



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 155/783 (19%), Positives = 293/783 (37%), Gaps = 135/783 (17%)

Query: 10   QQEMDS-LTFRNLQLAKRVELLQ---DELALSEPRGKKNKKSGESSSQLSQEQKSVFDED 65
            ++EM++ LT +  +L      L+   D+L L+  + +K K + E+  +   E+ +  DE 
Sbjct: 929  EEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988

Query: 66   LQKKIEENERLH------IQFFEADEQHKH----VEAELRSRLATLETEAAQHQAV---- 111
            + K  +E + L       +   +A+E   +     + +L  ++  LE    Q + V    
Sbjct: 989  IAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048

Query: 112  ------VDGLTRKYMETIEKLQNDKAKLE--VKSQTLEKEAKECRLRTEEC---QLQLKT 160
                  ++G  +   E+I  L+NDK +L+  +K +  E  A   R+  E+    QLQ K 
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108

Query: 161  LHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR-DIAGQALA---- 215
              ++L  R+EE    + E++    T  ++   L   L     ++  R + AG A +    
Sbjct: 1109 --KELQARIEE----LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162

Query: 216  -----------FVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASY 264
                         +DL  A L  H  T   ++        D+++ L ++      +N   
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQ-HEATAAALR----KKHADSVAELGEQI-----DNLQR 1212

Query: 265  VRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECES 324
            V+   E     F+   +D  + +E  +K K   E +               ++LE++   
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM--------------CRTLEDQMNE 1258

Query: 325  SLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAA 384
                   R++  E  + +  +T+   KLQT    L+    E + L+       LT     
Sbjct: 1259 H------RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT--- 1309

Query: 385  LHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSN- 443
                 D+ + + +    K A+ H L +A        D +       T    ++    S  
Sbjct: 1310 -QQLEDLKRQLEEEVKAKNALAHALQSARHDC----DLLREQYEEETEAKAELQRVLSKA 1364

Query: 444  NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRR 503
            N +       Y   A             +Q  ++     K L + L E+    EA+  + 
Sbjct: 1365 NSEVAQWRTKYETDA-------------IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKC 1411

Query: 504  ILLSSTESR-----EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKL 558
              L  T+ R     E L   V++S    + L++++ ++       K K E+    +    
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1471

Query: 559  KNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRE 618
            K   S        +NA   +   +   T K   + +Q    I  LT    S    +   E
Sbjct: 1472 KEARSLSTELFKLKNAYEESL--EHLETFKRENKNLQEE--ISDLTEQLGSSGKTIHELE 1527

Query: 619  DLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL------ALAEKSKEALTEEMK 672
              ++    A  +EL S L+ A++   H   E + L  +L      A  E+      EEM+
Sbjct: 1528 K-VRKQLEAEKMELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584

Query: 673  LASQNISRLQDELTTT--------------KRSYEDQLSMMSDHLCSMNETLSKQREEID 718
             A +N  R+ D L T+              K+  E  L+ M   L   N   ++ ++++ 
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644

Query: 719  TLK 721
            +L+
Sbjct: 1645 SLQ 1647



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 54/247 (21%), Positives = 102/247 (41%), Gaps = 27/247 (10%)

Query: 487  KPLLESVPYEEALANRRI----LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQL 542
            KPLL+S   E+ +A+ +     L  + E  E   ++++   EK+  L QEK    L+ Q 
Sbjct: 837  KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELE---EKMVSLLQEKNDLQLQVQA 893

Query: 543  AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGT 602
             +  L    +R    +KN    QL    +E     N   +DE    A L           
Sbjct: 894  EQDNLADAEERCDQLIKN--KIQLEAKVKE----MNERLEDEEEMNAELT---------A 938

Query: 603  LTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEK 662
              R  + E  +++   D ++      + ++  +    ++K  +   E   L + +A   K
Sbjct: 939  KKRKLEDECSELKRDIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 994

Query: 663  SKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKM 722
             K+AL E  + A  ++   +D++ T  ++ + +L    D L    E   K R +++  K 
Sbjct: 995  EKKALQEAHQQALDDLQAEEDKVNTLTKA-KVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053

Query: 723  SSKGNSK 729
              +G+ K
Sbjct: 1054 KLEGDLK 1060


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 148/721 (20%), Positives = 269/721 (37%), Gaps = 77/721 (10%)

Query: 22  QLAKRVELLQDELALSEPR-GKKNKKSGESSSQLSQEQKSVFDED--LQKKIEENERLHI 78
           Q A  V +L++++   E     ++K   E+ ++L Q QK V +++  LQ+  EE  +L +
Sbjct: 281 QQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKV 340

Query: 79  QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQ 138
              E  +Q K  E +    L   E  +   Q       +K  E +EK+Q ++  LE    
Sbjct: 341 DLLEQTKQGKRAERQRNEALYNAEELSKAFQQY----KKKVAEKLEKVQAEEEILERNLT 396

Query: 139 TLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLH 198
             EKE K  +   E C            G  +  L I+ EK+            L    +
Sbjct: 397 NCEKENKRLQ---ERC------------GLYKSELEILKEKL----------RQLKEENN 431

Query: 199 NRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISP-LNQKFSQY 257
           N + +L++       +A     V A L     TE R  I  ++S ++     L  KFS  
Sbjct: 432 NGKEKLRI-------MAVKNSEVMAQL-----TESRQSILKLESELENKDEILRDKFSLM 479

Query: 258 LHENASYVR-PLEEGMLHLFESITEDT---VTVLETTVKLKTFSEHLTSYICFLRKILPY 313
                  VR   +   L L +   E +   +  LE  +        L  +  +L K    
Sbjct: 480 NENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMS 539

Query: 314 QLKSLEEEC-----ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDG 368
              + E+ C      + L  S LR +      +++K+ A     Q   +L+    ++   
Sbjct: 540 SFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESS 599

Query: 369 LLRTNYSSVLTN-VGAALHGFHDVMKDISKHYSQK--AAIEHELPTATQKLITTNDCILS 425
            L    SS+ T  V    H   + +KD ++H   K        L T  ++L T    I +
Sbjct: 600 KL----SSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEA 655

Query: 426 SVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECML--QYKKKAAAYMK 483
               L        S F    +  +   S   K  S      S    L  Q ++K  AY  
Sbjct: 656 ENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSS 715

Query: 484 SLRKPLLESVPYEEALANRRILLSSTESREGLA-QQVQQSLEKISKLEQEKEHWMLEAQL 542
              K    +   E+ L  +   + S E+      +++  + EK  K+  E +H  +E Q+
Sbjct: 716 IAAK----NAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLE-QHKEMEKQI 770

Query: 543 AKI--KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
            ++  +LEK++Q+  ++ K     Q   + +++   S      E+  +   E ++    +
Sbjct: 771 ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830

Query: 601 GTLTRTSDSE---VPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL 657
             L      E   V  ++S  ++ K   +  + +L    +  + +      E   L K L
Sbjct: 831 KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890

Query: 658 ALAEKSKEALTEEMKLASQNISRLQDEL---TTTKRSYEDQLSMMSDHLCSMNETLSKQR 714
            +   S +  +E+  +    + + Q  L   T      ED  + +   +  + + L KQR
Sbjct: 891 KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR 950

Query: 715 E 715
           E
Sbjct: 951 E 951



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 119/584 (20%), Positives = 240/584 (41%), Gaps = 77/584 (13%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            KD++L+ LQ ++   T +  QL   +E+ ++EL L   + + NK+  E   QL ++ + V
Sbjct: 826  KDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFE--KQLKKKSEEV 883

Query: 62   FDEDLQKKIE-ENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
            +   LQK+++ +N  L     E  EQ+  ++  L+ +   L+ E  ++  + D  T K  
Sbjct: 884  Y--CLQKELKIKNHSLQ----ETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQT-KLE 936

Query: 121  ETIEKLQNDKAK-LEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG----------RL 169
            + + KL+ +  K  E  ++ L K  ++C     E  L+ + + E L+G          + 
Sbjct: 937  KQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIE-LTGTARQVKIEMDQY 995

Query: 170  EESLSIINEKVPF----NDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQD------ 219
            +E LS + +++       + K    + L++ L   + +L+ +  A + L  +Q       
Sbjct: 996  KEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL 1055

Query: 220  ---------LVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEE 270
                     L T L N H   +  ++       +  +  + QK    L E  + ++ L  
Sbjct: 1056 TEALQKREVLETELQNAHGELKSTLR------QLQELRDVLQKAQLSLEEKYTTIKDLTA 1109

Query: 271  GMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSL--CT 328
             +      I +    +LE    LK  +  L      +   L   ++    E E  +    
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTH-LDMTIREHRGEMEQKIIKLE 1168

Query: 329  SALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSV------LTNVG 382
              L    LEL +  K++ ++ +KLQ     L     E + ++  N   +      +    
Sbjct: 1169 GTLEKSELELKECNKQIESLNDKLQNAKEQL----REKEFIMLQNEQEISQLKKEIERTQ 1224

Query: 383  AALHGFHDVMKD----ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIA 438
              +     VMK+    I+  Y +   +  EL    +++  ++  +  +         +I 
Sbjct: 1225 QRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIE 1284

Query: 439  SFFSNNLDYFIASL---SYGPKAASGFISPLSAECMLQYK-----KKAAAYMKSLRKPL- 489
               S   D    S    ++G   A    +    E  L+ +     KK +A ++SL++   
Sbjct: 1285 RLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYH 1344

Query: 490  LESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEK 533
            +E + ++E  A  +I   S +S++   QQ+ + LEK +KLE E+
Sbjct: 1345 MEMISHQENHAKWKI---SADSQKSSVQQLNEQLEK-AKLELEE 1384



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 116/622 (18%), Positives = 244/622 (39%), Gaps = 70/622 (11%)

Query: 157 QLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAF 216
           ++K+L E L+   +++  ++ +    N +  +++ +++  L   R ++ M + A Q  A 
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQ----NHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS 285

Query: 217 VQDLVTALLNFHTYTEQRIQIF-PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLH- 274
           V  L   ++N       + ++    ++ ++    +  +  Q L E+      L+  +L  
Sbjct: 286 VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQ 345

Query: 275 --------------------LFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
                               L ++  +    V E   K++   E L   +    K    +
Sbjct: 346 TKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK----E 401

Query: 315 LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 374
            K L+E C   L  S L     +L Q  ++     EKL+    ++A+ ++E    L  + 
Sbjct: 402 NKRLQERC--GLYKSELEILKEKLRQLKEENNNGKEKLR----IMAVKNSEVMAQLTESR 455

Query: 375 SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 434
            S+L  + + L    ++++D     ++   ++  +    ++L      I SS V L +  
Sbjct: 456 QSIL-KLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS-L 513

Query: 435 GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 494
            KI S      + F    SY  K      S     C+   +       +   K  ++   
Sbjct: 514 EKIISQLPLKRELF-GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 572

Query: 495 YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKE----HWMLEA------QLAK 544
            ++  AN   L ++  S+  +     Q   K+S LE E      H + E+          
Sbjct: 573 IQKLHAN---LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMN 629

Query: 545 IKLEKENQRIADKLKNTGSAQLVGLAQENAAV----SNTAGQDEATAKAVLEPIQSTSLI 600
            + EKE QR+   ++   + +L+ +  EN+ +    ++   Q +   + +LE   ++S +
Sbjct: 630 KQYEKERQRLVTGIEELRT-KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL 688

Query: 601 GTLTRTSDSEVPDVESRED---LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL 657
            +      S++  +E + +   +  +   A+  EL  +L   + K            +++
Sbjct: 689 ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKI 748

Query: 658 ALA-EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS----DHLCSMNETLSK 712
            LA EK+K+   E+ K   + I RL+ +L    + +++Q   MS    D +C  +     
Sbjct: 749 CLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHL--- 805

Query: 713 QREEIDTLKMSSKGNSKKNKSR 734
             E +D L   SKG  KK   +
Sbjct: 806 --ESLDRLLTESKGEMKKENMK 825



 Score = 37.0 bits (84), Expect = 0.066
 Identities = 51/271 (18%), Positives = 114/271 (42%), Gaps = 35/271 (12%)

Query: 463  ISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQS 522
            +S L  E   Q +  A    K   K   ES  +E  L  ++++  +  +R+ +  ++ Q 
Sbjct: 939  VSKLEQELQKQRESSAEKLRKMEEK--CESAAHEADLKRQKVIELTGTARQ-VKIEMDQY 995

Query: 523  LEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQ 582
             E++SK+E+E  H                      LK  G  + + L+Q +  +  T  +
Sbjct: 996  KEELSKMEKEIMH----------------------LKRDGENKAMHLSQLDMILDQTKTE 1033

Query: 583  DEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQL-QLADS 641
             E    AV E       +  L  ++++E+ +   + ++++        EL S L QL + 
Sbjct: 1034 LEKKTNAVKE-------LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQEL 1086

Query: 642  KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD 701
            + V   A+     K   + + + E    +M++  +    L+ +    +R++E  L   + 
Sbjct: 1087 RDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE--LKQRAA 1144

Query: 702  HLCSMNETLSKQREEIDTLKMSSKGNSKKNK 732
             +  ++ T+ + R E++   +  +G  +K++
Sbjct: 1145 QVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 145/807 (17%), Positives = 305/807 (37%), Gaps = 155/807 (19%)

Query: 6    LRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDED 65
            L +++ E   L         + +L+Q+EL   E     +K   E + + SQ      ++ 
Sbjct: 650  LIQIEAENSDLKVNMAHRTSQFQLIQEELL--EKASNSSKLESEMTKKCSQ--LLTLEKQ 705

Query: 66   LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 125
            L++KI     +  +  E +++      ++RS    + TE  +     +   + ++E  ++
Sbjct: 706  LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKE 765

Query: 126  LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDT 185
            ++    +LE + +  +++ KE                       E+++S++ + +     
Sbjct: 766  MEKQIERLEAQLEKKDQQFKE----------------------QEKTMSMLQQDI---IC 800

Query: 186  KYSQYNALNVPLHNRRHQLKMRDI-AGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAI 244
            K     +L+  L   + ++K  ++   +AL  +Q+ V         +E+ I++  +DSA+
Sbjct: 801  KQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQV---------SEETIKVRQLDSAL 851

Query: 245  -----DTISPLNQ------KFSQYLHENASYVRPLEEGML---HLFESITEDTVTVL--- 287
                 + +  LNQ      KF + L + +  V  L++ +    H  +  +E  V +    
Sbjct: 852  EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTL 911

Query: 288  ------------------ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTS 329
                              +T  KL+     L   +   R+    +L+ +EE+CES+   +
Sbjct: 912  QQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEA 971

Query: 330  AL-RARNLELSQDMKKMTAVFEKLQTYIALL--ALPSTEPDGLLRTNYSS----VLTNVG 382
             L R + +EL+   +++    ++ +  ++ +   +   + DG  +  + S    +L    
Sbjct: 972  DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK 1031

Query: 383  AALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFS 442
              L    + +K++ K    + + E EL  A QK              L N  G++ S   
Sbjct: 1032 TELEKKTNAVKELEK---LQHSTETELTEALQKREVLE-------TELQNAHGELKSTLR 1081

Query: 443  --NNLDYFIASLSYGPKAASGFISPLSA---ECMLQYK--------------------KK 477
                L   +       +     I  L+A   EC ++ +                    K+
Sbjct: 1082 QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQ 1141

Query: 478  AAAYMKSLRKPLLES--------VPYEEALANRRILLSSTESR-EGLAQQVQQSLEKISK 528
             AA +  L   + E         +  E  L    + L     + E L  ++Q + E++  
Sbjct: 1142 RAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL-- 1199

Query: 529  LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSA-------------QLVGLAQE-NA 574
              +EKE  ML+ +    +L+KE +R   ++K   S              + + L QE   
Sbjct: 1200 --REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257

Query: 575  AVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTS 634
                        A+A  + +Q+   I  L+   + ++  +   +D   NH       L  
Sbjct: 1258 TREQVQNSHTELAEARHQQVQAQREIERLSSELE-DMKQLSKEKDAHGNH-------LAE 1309

Query: 635  QLQLADSKSVHFYAECRALSKRL-ALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 693
            +L  +  +  H  A  +A  K+L A  E  KEA   EM    +N ++ +    + K S +
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQ 1369

Query: 694  ---DQLSMMSDHLCSMNETLSKQREEI 717
               +QL      L    +T+S   +++
Sbjct: 1370 QLNEQLEKAKLELEEAQDTVSNLHQQV 1396


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 141/707 (19%), Positives = 267/707 (37%), Gaps = 84/707 (11%)

Query: 3    DQSLRKLQQEMDSLTF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESS 51
            +  + KLQ E++S+T        + ++LAK V      LQD   L +   ++        
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 52   SQLSQEQKSVFDE-DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQ 109
             QL +E+ S+ D+ D + + ++N   HI          K    +  S +  LE    + Q
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 110  AVVDGLTRKYME---TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLS 166
              ++ LT++Y E     +KL+  K +L                     Q +L  L  DL 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRL---------------------QQELDDLVVDLD 1437

Query: 167  GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALL 225
             + +   ++  ++  F+     + N  +     R R + + R+   +AL+  + L  AL 
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL- 1496

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                  E       + + ++ +        + +HE     R LE  M  +   + E+   
Sbjct: 1497 --EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELED 1553

Query: 286  VLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM 345
             L+ T   K     L   +  L+      L++ +E+ E          +  +L + + + 
Sbjct: 1554 ELQATEDAKL---RLEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEY 1601

Query: 346  TAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI 405
                E  +   AL A    + +G L+     +     +A+ G  + +K + K  +Q    
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDF 1657

Query: 406  EHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA------- 458
            + EL  A              + A      K A     +L      L+   +A       
Sbjct: 1658 QRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709

Query: 459  ----ASGFISPLSAECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 513
                A    S LS    LQ  K++  A +  L + L E     EA+++R  +  +T+  E
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAE 1767

Query: 514  GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
             L+ ++        K E  ++    + +  + KL +    +  K K+T +A    +AQ  
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827

Query: 574  AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 633
              V   A + +A  K++ +  +   L   L +  D      + +E   K +  AR+ +L 
Sbjct: 1828 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLK 1883

Query: 634  SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISR 680
             QL+ A+ +S    A  R L + L  A +S EA+  E+      + R
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 165/777 (21%), Positives = 301/777 (38%), Gaps = 107/777 (13%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKN---KKSGESSSQLSQEQK 59
            + +  LQ ++  L    +QLAK+ E LQ  LA L +   +KN   KK  E    +S  Q+
Sbjct: 1069 EQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 60   SVFDE-------DLQKKI--EENERLHIQFFEA-------DEQHKHVEAELRSRLATLET 103
             +  E       + QK+   EE E L  +  +         E     E E+      L+ 
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 104  EAAQHQAVVDGLTRKYMETIEKL-------QNDKAKLEVKSQTLEKE----AKECRLRTE 152
            E   H+A V  + +K+ + +E+L       +  KA L+   QTLEKE    A E R+   
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG- 1244

Query: 153  ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK-----MR 207
                Q K   E    +LE  +  +  K    +   ++   LN  +H  +++++     + 
Sbjct: 1245 ----QAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLN 1297

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLN--QKFSQYLHENASYV 265
            +  G+A+   +D V +L +    T++ +Q        +T   LN   K  Q   E  S  
Sbjct: 1298 EAEGKAIKLAKD-VASLSSQLQDTQELLQ-------EETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 266  RPLEEGM---LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC 322
              L+E M    +L   I+   + + ++  KL+ F+  +        + L    K  ++E 
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEI 1401

Query: 323  ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSSVLTN 380
            E+             L+Q  ++  A ++KL+     L     E D L+    N   +++N
Sbjct: 1402 EN-------------LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSN 1445

Query: 381  VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASF 440
            +      F  ++ +  K+ S K A E +   A  +   T    L+  +     A +    
Sbjct: 1446 LEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 441  FSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALA 500
             +  L   +  L          +        L+  K+A        K  LE +  +E  A
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHE------LEKSKRALETQMEEMKTQLEELE-DELQA 1557

Query: 501  NRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKN 560
                 L    + + L  Q ++ L+   +  +EK    L+ QL + + E E++R    L  
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAA 1616

Query: 561  TGSAQLVGLAQ--ENAAVSNTAGQDEATAKAVLEPIQSTSLIGTL--TRTSDSEVPDVES 616
                +L G  +  E  A S   G++EA  +      Q       L   R S  E+     
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
              +       A +++L   L  A+        E   L++ LA +   + AL +E +    
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
             I++L++EL       +  +  MSD +       ++Q E++     + +  ++KN+S
Sbjct: 1737 RIAQLEEEL----EEEQGNMEAMSDRV----RKATQQAEQLSNELATERSTAQKNES 1785



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 156/811 (19%), Positives = 306/811 (37%), Gaps = 135/811 (16%)

Query: 21   LQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENE---- 74
            ++LA + + L++ L   E R ++ +  G+   QL  E+K +  +  DL++++EE E    
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQMLDLEEQLEEEEAARQ 967

Query: 75   RLHIQFFEADEQHKHVEAE-----------------LRSRLATLETEAAQHQAVVDGLTR 117
            +L ++   A+ + K +E E                 L  R++ L T  A+ +     LT+
Sbjct: 968  KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027

Query: 118  -----------------KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKT 160
                             K  ++ ++L+  K KLE  +    ++  + + +  E ++QL  
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 161  LHEDLS---GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR-----HQLKMRDIAGQ 212
              E+L     RL++ ++  N  +          + L   L + R      + + RD+  +
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147

Query: 213  ALAFVQDLVTALLNFHTYTEQRI----QIFPVDSAID--------TISPLNQKFSQYLHE 260
              A   +L   L +  T  E R     ++  +  A+D         +  + QK +Q + E
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207

Query: 261  NASYVRPLEEGMLHL------FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
                +   +    +L       E    D    L    + K   EH        +K L  Q
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQ 1260

Query: 315  LKSLEEEC-ESSLCTSALRARNLELSQDMKKMTAVFE-------KLQTYIALLALPSTEP 366
            ++ L+ +C +     + L  +  +L  +++ +T +         KL   +A L+    + 
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 367  DGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSS 426
              LL+      L NV   L    +    +     ++   +  L    + + T N      
Sbjct: 1321 QELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLN------ 1370

Query: 427  VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAY---MK 483
             + L++   K+  F S      + +L  G K     I  L+     QY++KAAAY    K
Sbjct: 1371 -IQLSDSKKKLQDFAST-----VEALEEGKKRFQKEIENLTQ----QYEEKAAAYDKLEK 1420

Query: 484  SLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKI-SKLEQEKEHWMLEAQ- 541
            +  +   E       L N+R L+S+ E ++    Q+    + I SK   E++    EA+ 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 542  -----LAKIKLEKENQRIADKLKNTG---SAQLVGLAQENAAVSNTAGQDEATAKAVLEP 593
                 L+  +  +E     ++L+ T     A++  L      V     + E + +A+   
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 594  IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD----------SKS 643
            ++    + T     + E+   E  +  ++ +  A   +    LQ  D           + 
Sbjct: 1541 MEE---MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597

Query: 644  VHFY-AECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDH 702
            +H Y  E     K+ ALA  +K+ L  ++K    ++    D     +     QL  +   
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 703  LCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
            +      L   R   D +  ++K N KK KS
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKS 1684



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 152/771 (19%), Positives = 294/771 (38%), Gaps = 125/771 (16%)

Query: 21   LQLAKRVELLQ---DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEEN 73
            LQ+ ++ E +Q   DEL  ++ R +K     K+  +  SQL++E K++  E LQ + E  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-- 901

Query: 74   ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 133
                  + EA+E        +R RLA  + E  +    ++    +  +  ++LQ ++ K+
Sbjct: 902  -----LYAEAEE--------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 134  EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 193
              +   LE++ +E     ++ QL+  T    +  +LE+ + +++++              
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ-------------- 993

Query: 194  NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQ 252
            N  L   R  L+ R         + DL T L       +   ++    +S I  +    +
Sbjct: 994  NNKLSKERKLLEER---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 253  KFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC------- 305
            K  +   E     R LE       E I +    + E  ++L    E L + +        
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104

Query: 306  ----FLRKI--LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 359
                 L+KI  L   +  L+E+ +S       RA   +  +  + +    E L+T +   
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-D 1157

Query: 360  ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
             L ST     LR      +T +  AL       ++   H +Q   +  +   A ++L   
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 420  NDCILSSVVALTNGAGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
             +    +   L      +    ++       L      + +  K     +  L ++C   
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 474  YKKKAAA---------YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQS 522
             + +A            ++S+   L E+      LA     LSS   +++E L ++ +Q 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 523  LEKISKLEQ-EKEHWMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQL 566
            L   +KL Q E+E   L+ QL     AK  LE+     N +++D  K      +T  A  
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 567  VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             G  +    + N   Q E  A A  + ++ T     L +  D  V D++++  L+ N   
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN--- 1445

Query: 627  ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
                     L+    K     AE + +S + A      EA   E +  + +++R  +E  
Sbjct: 1446 ---------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 687  TTKRSYEDQLSMMS---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
              K   E    M+    + L S  + + K   E++  K + +   ++ K++
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 141/707 (19%), Positives = 267/707 (37%), Gaps = 84/707 (11%)

Query: 3    DQSLRKLQQEMDSLTF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESS 51
            +  + KLQ E++S+T        + ++LAK V      LQD   L +   ++        
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 52   SQLSQEQKSVFDE-DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQ 109
             QL +E+ S+ D+ D + + ++N   HI          K    +  S +  LE    + Q
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 110  AVVDGLTRKYME---TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLS 166
              ++ LT++Y E     +KL+  K +L                     Q +L  L  DL 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRL---------------------QQELDDLVVDLD 1444

Query: 167  GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALL 225
             + +   ++  ++  F+     + N  +     R R + + R+   +AL+  + L  AL 
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL- 1503

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                  E       + + ++ +        + +HE     R LE  M  +   + E+   
Sbjct: 1504 --EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELED 1560

Query: 286  VLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM 345
             L+ T   K     L   +  L+      L++ +E+ E          +  +L + + + 
Sbjct: 1561 ELQATEDAKL---RLEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEY 1608

Query: 346  TAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI 405
                E  +   AL A    + +G L+     +     +A+ G  + +K + K  +Q    
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDF 1664

Query: 406  EHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA------- 458
            + EL  A              + A      K A     +L      L+   +A       
Sbjct: 1665 QRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716

Query: 459  ----ASGFISPLSAECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 513
                A    S LS    LQ  K++  A +  L + L E     EA+++R  +  +T+  E
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAE 1774

Query: 514  GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
             L+ ++        K E  ++    + +  + KL +    +  K K+T +A    +AQ  
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834

Query: 574  AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 633
              V   A + +A  K++ +  +   L   L +  D      + +E   K +  AR+ +L 
Sbjct: 1835 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLK 1890

Query: 634  SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISR 680
             QL+ A+ +S    A  R L + L  A +S EA+  E+      + R
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 165/777 (21%), Positives = 301/777 (38%), Gaps = 107/777 (13%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKN---KKSGESSSQLSQEQK 59
            + +  LQ ++  L    +QLAK+ E LQ  LA L +   +KN   KK  E    +S  Q+
Sbjct: 1076 EQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 60   SVFDE-------DLQKKI--EENERLHIQFFEA-------DEQHKHVEAELRSRLATLET 103
             +  E       + QK+   EE E L  +  +         E     E E+      L+ 
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 104  EAAQHQAVVDGLTRKYMETIEKL-------QNDKAKLEVKSQTLEKE----AKECRLRTE 152
            E   H+A V  + +K+ + +E+L       +  KA L+   QTLEKE    A E R+   
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG- 1251

Query: 153  ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK-----MR 207
                Q K   E    +LE  +  +  K    +   ++   LN  +H  +++++     + 
Sbjct: 1252 ----QAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLN 1304

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLN--QKFSQYLHENASYV 265
            +  G+A+   +D V +L +    T++ +Q        +T   LN   K  Q   E  S  
Sbjct: 1305 EAEGKAIKLAKD-VASLSSQLQDTQELLQ-------EETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 266  RPLEEGM---LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC 322
              L+E M    +L   I+   + + ++  KL+ F+  +        + L    K  ++E 
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEI 1408

Query: 323  ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSSVLTN 380
            E+             L+Q  ++  A ++KL+     L     E D L+    N   +++N
Sbjct: 1409 EN-------------LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSN 1452

Query: 381  VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASF 440
            +      F  ++ +  K+ S K A E +   A  +   T    L+  +     A +    
Sbjct: 1453 LEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 441  FSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALA 500
             +  L   +  L          +        L+  K+A        K  LE +  +E  A
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHE------LEKSKRALETQMEEMKTQLEELE-DELQA 1564

Query: 501  NRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKN 560
                 L    + + L  Q ++ L+   +  +EK    L+ QL + + E E++R    L  
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAA 1623

Query: 561  TGSAQLVGLAQ--ENAAVSNTAGQDEATAKAVLEPIQSTSLIGTL--TRTSDSEVPDVES 616
                +L G  +  E  A S   G++EA  +      Q       L   R S  E+     
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
              +       A +++L   L  A+        E   L++ LA +   + AL +E +    
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
             I++L++EL       +  +  MSD +       ++Q E++     + +  ++KN+S
Sbjct: 1744 RIAQLEEEL----EEEQGNMEAMSDRV----RKATQQAEQLSNELATERSTAQKNES 1792



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 156/811 (19%), Positives = 306/811 (37%), Gaps = 135/811 (16%)

Query: 21   LQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENE---- 74
            ++LA + + L++ L   E R ++ +  G+   QL  E+K +  +  DL++++EE E    
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQMLDLEEQLEEEEAARQ 974

Query: 75   RLHIQFFEADEQHKHVEAE-----------------LRSRLATLETEAAQHQAVVDGLTR 117
            +L ++   A+ + K +E E                 L  R++ L T  A+ +     LT+
Sbjct: 975  KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034

Query: 118  -----------------KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKT 160
                             K  ++ ++L+  K KLE  +    ++  + + +  E ++QL  
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 161  LHEDLS---GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR-----HQLKMRDIAGQ 212
              E+L     RL++ ++  N  +          + L   L + R      + + RD+  +
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154

Query: 213  ALAFVQDLVTALLNFHTYTEQRI----QIFPVDSAID--------TISPLNQKFSQYLHE 260
              A   +L   L +  T  E R     ++  +  A+D         +  + QK +Q + E
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214

Query: 261  NASYVRPLEEGMLHL------FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
                +   +    +L       E    D    L    + K   EH        +K L  Q
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQ 1267

Query: 315  LKSLEEEC-ESSLCTSALRARNLELSQDMKKMTAVFE-------KLQTYIALLALPSTEP 366
            ++ L+ +C +     + L  +  +L  +++ +T +         KL   +A L+    + 
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 367  DGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSS 426
              LL+      L NV   L    +    +     ++   +  L    + + T N      
Sbjct: 1328 QELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLN------ 1377

Query: 427  VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAY---MK 483
             + L++   K+  F S      + +L  G K     I  L+     QY++KAAAY    K
Sbjct: 1378 -IQLSDSKKKLQDFAST-----VEALEEGKKRFQKEIENLTQ----QYEEKAAAYDKLEK 1427

Query: 484  SLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKI-SKLEQEKEHWMLEAQ- 541
            +  +   E       L N+R L+S+ E ++    Q+    + I SK   E++    EA+ 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 542  -----LAKIKLEKENQRIADKLKNTG---SAQLVGLAQENAAVSNTAGQDEATAKAVLEP 593
                 L+  +  +E     ++L+ T     A++  L      V     + E + +A+   
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 594  IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD----------SKS 643
            ++    + T     + E+   E  +  ++ +  A   +    LQ  D           + 
Sbjct: 1548 MEE---MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604

Query: 644  VHFY-AECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDH 702
            +H Y  E     K+ ALA  +K+ L  ++K    ++    D     +     QL  +   
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 703  LCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
            +      L   R   D +  ++K N KK KS
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKS 1691



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 152/771 (19%), Positives = 294/771 (38%), Gaps = 125/771 (16%)

Query: 21   LQLAKRVELLQ---DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEEN 73
            LQ+ ++ E +Q   DEL  ++ R +K     K+  +  SQL++E K++  E LQ + E  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-- 908

Query: 74   ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 133
                  + EA+E        +R RLA  + E  +    ++    +  +  ++LQ ++ K+
Sbjct: 909  -----LYAEAEE--------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 134  EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 193
              +   LE++ +E     ++ QL+  T    +  +LE+ + +++++              
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ-------------- 1000

Query: 194  NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQ 252
            N  L   R  L+ R         + DL T L       +   ++    +S I  +    +
Sbjct: 1001 NNKLSKERKLLEER---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 253  KFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC------- 305
            K  +   E     R LE       E I +    + E  ++L    E L + +        
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 306  ----FLRKI--LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 359
                 L+KI  L   +  L+E+ +S       RA   +  +  + +    E L+T +   
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-D 1164

Query: 360  ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
             L ST     LR      +T +  AL       ++   H +Q   +  +   A ++L   
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 420  NDCILSSVVALTNGAGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
             +    +   L      +    ++       L      + +  K     +  L ++C   
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 474  YKKKAAA---------YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQS 522
             + +A            ++S+   L E+      LA     LSS   +++E L ++ +Q 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 523  LEKISKLEQ-EKEHWMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQL 566
            L   +KL Q E+E   L+ QL     AK  LE+     N +++D  K      +T  A  
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 567  VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             G  +    + N   Q E  A A  + ++ T     L +  D  V D++++  L+ N   
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN--- 1452

Query: 627  ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
                     L+    K     AE + +S + A      EA   E +  + +++R  +E  
Sbjct: 1453 ---------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 687  TTKRSYEDQLSMMS---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
              K   E    M+    + L S  + + K   E++  K + +   ++ K++
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 140/698 (20%), Positives = 265/698 (37%), Gaps = 84/698 (12%)

Query: 3    DQSLRKLQQEMDSLTF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESS 51
            +  + KLQ E++S+T        + ++LAK V      LQD   L +   ++        
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 52   SQLSQEQKSVFDE-DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQ 109
             QL +E+ S+ D+ D + + ++N   HI          K    +  S +  LE    + Q
Sbjct: 1346 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405

Query: 110  AVVDGLTRKYME---TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLS 166
              ++ LT++Y E     +KL+  K +L                     Q +L  L  DL 
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRL---------------------QQELDDLVVDLD 1444

Query: 167  GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALL 225
             + +   ++  ++  F+     + N  +     R R + + R+   +AL+  + L  AL 
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL- 1503

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                  E       + + ++ +        + +HE     R LE  M  +   + E+   
Sbjct: 1504 --EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELED 1560

Query: 286  VLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM 345
             L+ T   K     L   +  L+      L++ +E+ E          +  +L + + + 
Sbjct: 1561 ELQATEDAKL---RLEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEY 1608

Query: 346  TAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI 405
                E  +   AL A    + +G L+     +     +A+ G  + +K + K  +Q    
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDF 1664

Query: 406  EHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA------- 458
            + EL  A              + A      K A     +L      L+   +A       
Sbjct: 1665 QRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716

Query: 459  ----ASGFISPLSAECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 513
                A    S LS    LQ  K++  A +  L + L E     EA+++R  +  +T+  E
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAE 1774

Query: 514  GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
             L+ ++        K E  ++    + +  + KL +    +  K K+T +A    +AQ  
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834

Query: 574  AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 633
              V   A + +A  K++ +  +   L   L +  D      + +E   K +  AR+ +L 
Sbjct: 1835 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLK 1890

Query: 634  SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEM 671
             QL+ A+ +S    A  R L + L  A +S EA+  E+
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 165/777 (21%), Positives = 301/777 (38%), Gaps = 107/777 (13%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKN---KKSGESSSQLSQEQK 59
            + +  LQ ++  L    +QLAK+ E LQ  LA L +   +KN   KK  E    +S  Q+
Sbjct: 1076 EQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 60   SVFDE-------DLQKKI--EENERLHIQFFEA-------DEQHKHVEAELRSRLATLET 103
             +  E       + QK+   EE E L  +  +         E     E E+      L+ 
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 104  EAAQHQAVVDGLTRKYMETIEKL-------QNDKAKLEVKSQTLEKE----AKECRLRTE 152
            E   H+A V  + +K+ + +E+L       +  KA L+   QTLEKE    A E R+   
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG- 1251

Query: 153  ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK-----MR 207
                Q K   E    +LE  +  +  K    +   ++   LN  +H  +++++     + 
Sbjct: 1252 ----QAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLN 1304

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLN--QKFSQYLHENASYV 265
            +  G+A+   +D V +L +    T++ +Q        +T   LN   K  Q   E  S  
Sbjct: 1305 EAEGKAIKLAKD-VASLSSQLQDTQELLQ-------EETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 266  RPLEEGM---LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC 322
              L+E M    +L   I+   + + ++  KL+ F+  +        + L    K  ++E 
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEI 1408

Query: 323  ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSSVLTN 380
            E+             L+Q  ++  A ++KL+     L     E D L+    N   +++N
Sbjct: 1409 EN-------------LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSN 1452

Query: 381  VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASF 440
            +      F  ++ +  K+ S K A E +   A  +   T    L+  +     A +    
Sbjct: 1453 LEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 441  FSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALA 500
             +  L   +  L          +        L+  K+A        K  LE +  +E  A
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHE------LEKSKRALETQMEEMKTQLEELE-DELQA 1564

Query: 501  NRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKN 560
                 L    + + L  Q ++ L+   +  +EK    L+ QL + + E E++R    L  
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAA 1623

Query: 561  TGSAQLVGLAQ--ENAAVSNTAGQDEATAKAVLEPIQSTSLIGTL--TRTSDSEVPDVES 616
                +L G  +  E  A S   G++EA  +      Q       L   R S  E+     
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
              +       A +++L   L  A+        E   L++ LA +   + AL +E +    
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
             I++L++EL       +  +  MSD +       ++Q E++     + +  ++KN+S
Sbjct: 1744 RIAQLEEEL----EEEQGNMEAMSDRV----RKATQQAEQLSNELATERSTAQKNES 1792



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 156/811 (19%), Positives = 306/811 (37%), Gaps = 135/811 (16%)

Query: 21   LQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENE---- 74
            ++LA + + L++ L   E R ++ +  G+   QL  E+K +  +  DL++++EE E    
Sbjct: 918  VRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQMLDLEEQLEEEEAARQ 974

Query: 75   RLHIQFFEADEQHKHVEAE-----------------LRSRLATLETEAAQHQAVVDGLTR 117
            +L ++   A+ + K +E E                 L  R++ L T  A+ +     LT+
Sbjct: 975  KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034

Query: 118  -----------------KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKT 160
                             K  ++ ++L+  K KLE  +    ++  + + +  E ++QL  
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094

Query: 161  LHEDLS---GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR-----HQLKMRDIAGQ 212
              E+L     RL++ ++  N  +          + L   L + R      + + RD+  +
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154

Query: 213  ALAFVQDLVTALLNFHTYTEQRI----QIFPVDSAID--------TISPLNQKFSQYLHE 260
              A   +L   L +  T  E R     ++  +  A+D         +  + QK +Q + E
Sbjct: 1155 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214

Query: 261  NASYVRPLEEGMLHL------FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
                +   +    +L       E    D    L    + K   EH        +K L  Q
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQ 1267

Query: 315  LKSLEEEC-ESSLCTSALRARNLELSQDMKKMTAVFE-------KLQTYIALLALPSTEP 366
            ++ L+ +C +     + L  +  +L  +++ +T +         KL   +A L+    + 
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 367  DGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSS 426
              LL+      L NV   L    +    +     ++   +  L    + + T N      
Sbjct: 1328 QELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLN------ 1377

Query: 427  VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAY---MK 483
             + L++   K+  F S      + +L  G K     I  L+     QY++KAAAY    K
Sbjct: 1378 -IQLSDSKKKLQDFAST-----VEALEEGKKRFQKEIENLTQ----QYEEKAAAYDKLEK 1427

Query: 484  SLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKI-SKLEQEKEHWMLEAQ- 541
            +  +   E       L N+R L+S+ E ++    Q+    + I SK   E++    EA+ 
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487

Query: 542  -----LAKIKLEKENQRIADKLKNTG---SAQLVGLAQENAAVSNTAGQDEATAKAVLEP 593
                 L+  +  +E     ++L+ T     A++  L      V     + E + +A+   
Sbjct: 1488 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547

Query: 594  IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD----------SKS 643
            ++    + T     + E+   E  +  ++ +  A   +    LQ  D           + 
Sbjct: 1548 MEE---MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604

Query: 644  VHFY-AECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDH 702
            +H Y  E     K+ ALA  +K+ L  ++K    ++    D     +     QL  +   
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 703  LCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
            +      L   R   D +  ++K N KK KS
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKS 1691



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 34/208 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            ++ L + Q  M++++ R  +  ++ E L +ELA      +KN    ES+ Q  + Q    
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQ---- 1800

Query: 63   DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
            +++L+ K+ E E               V+++ +S +A LE + AQ +  V+   R+    
Sbjct: 1801 NKELRSKLHEMEGA-------------VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847

Query: 123  IEKL-QNDKAKLEVKSQTLE--KEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI---- 175
             + L Q DK   E+  Q  +  K A++ + + E+   ++K L   L    EES  I    
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907

Query: 176  ------INEKVPFNDTKYSQYNALNVPL 197
                  ++E    N+    + NAL   L
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 152/771 (19%), Positives = 294/771 (38%), Gaps = 125/771 (16%)

Query: 21   LQLAKRVELLQ---DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEEN 73
            LQ+ ++ E +Q   DEL  ++ R +K     K+  +  SQL++E K++  E LQ + E  
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-- 908

Query: 74   ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 133
                  + EA+E        +R RLA  + E  +    ++    +  +  ++LQ ++ K+
Sbjct: 909  -----LYAEAEE--------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 134  EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 193
              +   LE++ +E     ++ QL+  T    +  +LE+ + +++++              
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ-------------- 1000

Query: 194  NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQ 252
            N  L   R  L+ R         + DL T L       +   ++    +S I  +    +
Sbjct: 1001 NNKLSKERKLLEER---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 253  KFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC------- 305
            K  +   E     R LE       E I +    + E  ++L    E L + +        
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 306  ----FLRKI--LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 359
                 L+KI  L   +  L+E+ +S       RA   +  +  + +    E L+T +   
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-D 1164

Query: 360  ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
             L ST     LR      +T +  AL       ++   H +Q   +  +   A ++L   
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQ 1218

Query: 420  NDCILSSVVALTNGAGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
             +    +   L      +    ++       L      + +  K     +  L ++C   
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 474  YKKKAAA---------YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQS 522
             + +A            ++S+   L E+      LA     LSS   +++E L ++ +Q 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338

Query: 523  LEKISKLEQ-EKEHWMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQL 566
            L   +KL Q E+E   L+ QL     AK  LE+     N +++D  K      +T  A  
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398

Query: 567  VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             G  +    + N   Q E  A A  + ++ T     L +  D  V D++++  L+ N   
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN--- 1452

Query: 627  ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
                     L+    K     AE + +S + A      EA   E +  + +++R  +E  
Sbjct: 1453 ---------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 687  TTKRSYEDQLSMMS---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
              K   E    M+    + L S  + + K   E++  K + +   ++ K++
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 140/698 (20%), Positives = 265/698 (37%), Gaps = 84/698 (12%)

Query: 3    DQSLRKLQQEMDSLTF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESS 51
            +  + KLQ E++S+T        + ++LAK V      LQD   L +   ++        
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 52   SQLSQEQKSVFDE-DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQ 109
             QL +E+ S+ D+ D + + ++N   HI          K    +  S +  LE    + Q
Sbjct: 1339 RQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398

Query: 110  AVVDGLTRKYME---TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLS 166
              ++ LT++Y E     +KL+  K +L                     Q +L  L  DL 
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRL---------------------QQELDDLVVDLD 1437

Query: 167  GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALL 225
             + +   ++  ++  F+     + N  +     R R + + R+   +AL+  + L  AL 
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL- 1496

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                  E       + + ++ +        + +HE     R LE  M  +   + E+   
Sbjct: 1497 --EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELED 1553

Query: 286  VLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM 345
             L+ T   K     L   +  L+      L++ +E+ E          +  +L + + + 
Sbjct: 1554 ELQATEDAKL---RLEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEY 1601

Query: 346  TAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI 405
                E  +   AL A    + +G L+     +     +A+ G  + +K + K  +Q    
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDF 1657

Query: 406  EHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA------- 458
            + EL  A              + A      K A     +L      L+   +A       
Sbjct: 1658 QRELEDARASR--------DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709

Query: 459  ----ASGFISPLSAECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 513
                A    S LS    LQ  K++  A +  L + L E     EA+++R  +  +T+  E
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAE 1767

Query: 514  GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
             L+ ++        K E  ++    + +  + KL +    +  K K+T +A    +AQ  
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827

Query: 574  AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 633
              V   A + +A  K++ +  +   L   L +  D      + +E   K +  AR+ +L 
Sbjct: 1828 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLK 1883

Query: 634  SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEM 671
             QL+ A+ +S    A  R L + L  A +S EA+  E+
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 165/777 (21%), Positives = 301/777 (38%), Gaps = 107/777 (13%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKN---KKSGESSSQLSQEQK 59
            + +  LQ ++  L    +QLAK+ E LQ  LA L +   +KN   KK  E    +S  Q+
Sbjct: 1069 EQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 60   SVFDE-------DLQKKI--EENERLHIQFFEA-------DEQHKHVEAELRSRLATLET 103
             +  E       + QK+   EE E L  +  +         E     E E+      L+ 
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 104  EAAQHQAVVDGLTRKYMETIEKL-------QNDKAKLEVKSQTLEKE----AKECRLRTE 152
            E   H+A V  + +K+ + +E+L       +  KA L+   QTLEKE    A E R+   
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG- 1244

Query: 153  ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK-----MR 207
                Q K   E    +LE  +  +  K    +   ++   LN  +H  +++++     + 
Sbjct: 1245 ----QAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLN 1297

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLN--QKFSQYLHENASYV 265
            +  G+A+   +D V +L +    T++ +Q        +T   LN   K  Q   E  S  
Sbjct: 1298 EAEGKAIKLAKD-VASLSSQLQDTQELLQ-------EETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 266  RPLEEGM---LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC 322
              L+E M    +L   I+   + + ++  KL+ F+  +        + L    K  ++E 
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--------EALEEGKKRFQKEI 1401

Query: 323  ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSSVLTN 380
            E+             L+Q  ++  A ++KL+     L     E D L+    N   +++N
Sbjct: 1402 EN-------------LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSN 1445

Query: 381  VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASF 440
            +      F  ++ +  K+ S K A E +   A  +   T    L+  +     A +    
Sbjct: 1446 LEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 441  FSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALA 500
             +  L   +  L          +        L+  K+A        K  LE +  +E  A
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHE------LEKSKRALETQMEEMKTQLEELE-DELQA 1557

Query: 501  NRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKN 560
                 L    + + L  Q ++ L+   +  +EK    L+ QL + + E E++R    L  
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR-QLQRQLHEYETELEDERKQRALAA 1616

Query: 561  TGSAQLVGLAQ--ENAAVSNTAGQDEATAKAVLEPIQSTSLIGTL--TRTSDSEVPDVES 616
                +L G  +  E  A S   G++EA  +      Q       L   R S  E+     
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
              +       A +++L   L  A+        E   L++ LA +   + AL +E +    
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
             I++L++EL       +  +  MSD +       ++Q E++     + +  ++KN+S
Sbjct: 1737 RIAQLEEEL----EEEQGNMEAMSDRV----RKATQQAEQLSNELATERSTAQKNES 1785



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 156/811 (19%), Positives = 306/811 (37%), Gaps = 135/811 (16%)

Query: 21   LQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENE---- 74
            ++LA + + L++ L   E R ++ +  G+   QL  E+K +  +  DL++++EE E    
Sbjct: 911  VRLAAKKQELEEILHEMEARLEEEEDRGQ---QLQAERKKMAQQMLDLEEQLEEEEAARQ 967

Query: 75   RLHIQFFEADEQHKHVEAE-----------------LRSRLATLETEAAQHQAVVDGLTR 117
            +L ++   A+ + K +E E                 L  R++ L T  A+ +     LT+
Sbjct: 968  KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027

Query: 118  -----------------KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKT 160
                             K  ++ ++L+  K KLE  +    ++  + + +  E ++QL  
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087

Query: 161  LHEDLS---GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR-----HQLKMRDIAGQ 212
              E+L     RL++ ++  N  +          + L   L + R      + + RD+  +
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147

Query: 213  ALAFVQDLVTALLNFHTYTEQRI----QIFPVDSAID--------TISPLNQKFSQYLHE 260
              A   +L   L +  T  E R     ++  +  A+D         +  + QK +Q + E
Sbjct: 1148 LEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207

Query: 261  NASYVRPLEEGMLHL------FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
                +   +    +L       E    D    L    + K   EH        +K L  Q
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH-------KKKKLEAQ 1260

Query: 315  LKSLEEEC-ESSLCTSALRARNLELSQDMKKMTAVFE-------KLQTYIALLALPSTEP 366
            ++ L+ +C +     + L  +  +L  +++ +T +         KL   +A L+    + 
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 367  DGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSS 426
              LL+      L NV   L    +    +     ++   +  L    + + T N      
Sbjct: 1321 QELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLN------ 1370

Query: 427  VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAY---MK 483
             + L++   K+  F S      + +L  G K     I  L+     QY++KAAAY    K
Sbjct: 1371 -IQLSDSKKKLQDFAST-----VEALEEGKKRFQKEIENLTQ----QYEEKAAAYDKLEK 1420

Query: 484  SLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKI-SKLEQEKEHWMLEAQ- 541
            +  +   E       L N+R L+S+ E ++    Q+    + I SK   E++    EA+ 
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480

Query: 542  -----LAKIKLEKENQRIADKLKNTG---SAQLVGLAQENAAVSNTAGQDEATAKAVLEP 593
                 L+  +  +E     ++L+ T     A++  L      V     + E + +A+   
Sbjct: 1481 KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540

Query: 594  IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD----------SKS 643
            ++    + T     + E+   E  +  ++ +  A   +    LQ  D           + 
Sbjct: 1541 MEE---MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597

Query: 644  VHFY-AECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDH 702
            +H Y  E     K+ ALA  +K+ L  ++K    ++    D     +     QL  +   
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 703  LCSMNETLSKQREEIDTLKMSSKGNSKKNKS 733
            +      L   R   D +  ++K N KK KS
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKS 1684



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 50/208 (24%), Positives = 92/208 (44%), Gaps = 34/208 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            ++ L + Q  M++++ R  +  ++ E L +ELA      +KN    ES+ Q  + Q    
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQ---- 1793

Query: 63   DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
            +++L+ K+ E E               V+++ +S +A LE + AQ +  V+   R+    
Sbjct: 1794 NKELRSKLHEMEGA-------------VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840

Query: 123  IEKL-QNDKAKLEVKSQTLE--KEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI---- 175
             + L Q DK   E+  Q  +  K A++ + + E+   ++K L   L    EES  I    
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900

Query: 176  ------INEKVPFNDTKYSQYNALNVPL 197
                  ++E    N+    + NAL   L
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKL 1928



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 152/771 (19%), Positives = 294/771 (38%), Gaps = 125/771 (16%)

Query: 21   LQLAKRVELLQ---DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEEN 73
            LQ+ ++ E +Q   DEL  ++ R +K     K+  +  SQL++E K++  E LQ + E  
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-- 901

Query: 74   ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 133
                  + EA+E        +R RLA  + E  +    ++    +  +  ++LQ ++ K+
Sbjct: 902  -----LYAEAEE--------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 134  EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 193
              +   LE++ +E     ++ QL+  T    +  +LE+ + +++++              
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ-------------- 993

Query: 194  NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQ 252
            N  L   R  L+ R         + DL T L       +   ++    +S I  +    +
Sbjct: 994  NNKLSKERKLLEER---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 253  KFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC------- 305
            K  +   E     R LE       E I +    + E  ++L    E L + +        
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104

Query: 306  ----FLRKI--LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 359
                 L+KI  L   +  L+E+ +S       RA   +  +  + +    E L+T +   
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-D 1157

Query: 360  ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
             L ST     LR      +T +  AL       ++   H +Q   +  +   A ++L   
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQ 1211

Query: 420  NDCILSSVVALTNGAGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
             +    +   L      +    ++       L      + +  K     +  L ++C   
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 474  YKKKAAA---------YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQS 522
             + +A            ++S+   L E+      LA     LSS   +++E L ++ +Q 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331

Query: 523  LEKISKLEQ-EKEHWMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQL 566
            L   +KL Q E+E   L+ QL     AK  LE+     N +++D  K      +T  A  
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391

Query: 567  VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             G  +    + N   Q E  A A  + ++ T     L +  D  V D++++  L+ N   
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN--- 1445

Query: 627  ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
                     L+    K     AE + +S + A      EA   E +  + +++R  +E  
Sbjct: 1446 ---------LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 687  TTKRSYEDQLSMMS---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
              K   E    M+    + L S  + + K   E++  K + +   ++ K++
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 151/739 (20%), Positives = 281/739 (38%), Gaps = 117/739 (15%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K+  +  LQ +++      +QL K+++ LQ  +   E    +  ++  +S   +++Q+S 
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE----EEIEAERASRAKAEKQRSD 1144

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
               +L++  E  E          E +K  EAE +     LE    QH+A    L +K+ +
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVP 181
            ++ +L      L+   Q LEKE  E ++  ++    ++T+ +   G LE+    + +++ 
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK-AKGNLEKMCRTLEDQL- 1262

Query: 182  FNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVD 241
                                 +LK ++   Q L  + DL          T QR       
Sbjct: 1263 --------------------SELKSKEEEQQRL--INDL----------TAQR------- 1283

Query: 242  SAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL- 300
                 +   + +FS+ L E  + V  L  G    F    E+    LE  +K K    H  
Sbjct: 1284 ---GRLQTESGEFSRQLDEKEALVSQLSRGK-QAFTQQIEELKRQLEEEIKAKNALAHAL 1339

Query: 301  --TSYICFLRKILPYQLKSLEEECESSL-CTSALRARNLELSQ-------DMKKMTAVFE 350
              + + C L +      +  EEE ES      AL   N E++Q       D  + T   E
Sbjct: 1340 QSSRHDCDLLR------EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393

Query: 351  KLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHE-- 408
            + +  +A     + E    +    +S+        +   D+M D+ +  +  AA++ +  
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 409  -----LPTATQKLITTN---DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAAS 460
                 L    QK   T+   +       +L     KI + +  +LD  + +L    K   
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQ 1512

Query: 461  GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQ 520
              IS L+ E + +  K+     K  ++   E    + AL       +S E  EG   ++Q
Sbjct: 1513 QEISDLT-EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE---ASLEHEEGKILRIQ 1568

Query: 521  QSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQ-------------LV 567
              L ++   + E +  + E      +L++ + RI + +++T  A+             + 
Sbjct: 1569 LELNQV---KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625

Query: 568  GLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMA 627
            G   E     N A +  A A   L   ++T   G L  T       + S+ED        
Sbjct: 1626 GDLNEMEIQLNHANRMAAEA---LRNYRNTQ--GILKDTQIHLDDALRSQED-------- 1672

Query: 628  RIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDE--- 684
                L  QL + + ++    AE   L   L   E+S++   +E+  AS+ +  L  +   
Sbjct: 1673 ----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728

Query: 685  LTTTKRSYEDQLSMMSDHL 703
            L  TK+  E  +S M   +
Sbjct: 1729 LINTKKKLETDISQMQGEM 1747



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 148/775 (19%), Positives = 292/775 (37%), Gaps = 115/775 (14%)

Query: 23   LAKRVELLQDELALSEPRGKKN--------KKSGESSSQLSQEQKSVFDED------LQK 68
            + +  + ++DELA SE + K+         K+  +   Q+  E + + D +      ++ 
Sbjct: 858  MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917

Query: 69   KIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLT-------RKYME 121
            KI+   ++  +  E  E  + + AEL ++   LE E ++ +  +D L        ++   
Sbjct: 918  KIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 976

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH--EDLSGRLEESLSIINEK 179
            T  K++N   ++    +T+ K  KE +   E  Q  L  L   ED    L ++   + ++
Sbjct: 977  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1036

Query: 180  VPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI---- 235
            V   +    Q   L + L   + +L+        L   Q+ +  + N     ++++    
Sbjct: 1037 VDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQLDEKLKKKE 1090

Query: 236  -QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 294
             +I  + S I+    L  +  + + E  + +  LEE +               E   + K
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI-------------EAERASRAK 1137

Query: 295  TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQT 354
               +         R  L  +L+ + E  E +       +  +E++   KK  A F+K++ 
Sbjct: 1138 AEKQ---------RSDLSRELEEISERLEEA---GGATSAQIEMN---KKREAEFQKMRR 1182

Query: 355  YIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ 414
             +    L        LR  ++  +  +G  +     V + + K  S+      +L +  +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242

Query: 415  ----------KLITTNDCILSSVVA-----------LTNGAGKI---ASFFSNNLDY--- 447
                      K+  T +  LS + +           LT   G++   +  FS  LD    
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302

Query: 448  FIASLSYGPKAASGFISPLSAECMLQYKKKAA---AYMKSLRKPLLESVPYEE-----AL 499
             ++ LS G +A +  I  L  +   + K K A   A   S     L    YEE     A 
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362

Query: 500  ANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA---- 555
              R +  ++TE  +   +    ++++  +LE+ K+      Q A+  +E  N + A    
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422

Query: 556  --DKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPD 613
               +L+N     ++ + + NAA +    +     K + E  Q           S  E   
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482

Query: 614  VESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKL 673
            + +    IKN Y     E   QL+    ++ +   E   L++++A   K    L +  K 
Sbjct: 1483 LGTELFKIKNAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538

Query: 674  ASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNET-------LSKQREEIDTLK 721
              Q    LQ  L   + S E +   +      +N+        ++++ EEID LK
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 43/195 (22%), Positives = 94/195 (48%), Gaps = 25/195 (12%)

Query: 3    DQSLRKLQQEMDSLT--FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
            +  + ++Q EM+ +    RN +  K  + + D   ++E    + KK  ++S+ L + +K+
Sbjct: 1737 ETDISQMQGEMEDILQEARNAE-EKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKN 1791

Query: 61   VFD--EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL--- 115
            +    +DLQ +++E E+L ++     +Q + +EA +R     +E+E  ++   V GL   
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALK--GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849

Query: 116  ----------TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDL 165
                      T +  + I +LQ+   KL+ K ++ +++A+E   ++     + + L  +L
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909

Query: 166  SGRLEESLSIINEKV 180
                EE   I   +V
Sbjct: 1910 E-EAEERADIAESQV 1923


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 151/739 (20%), Positives = 281/739 (38%), Gaps = 117/739 (15%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K+  +  LQ +++      +QL K+++ LQ  +   E    +  ++  +S   +++Q+S 
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE----EEIEAERASRAKAEKQRSD 1144

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
               +L++  E  E          E +K  EAE +     LE    QH+A    L +K+ +
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVP 181
            ++ +L      L+   Q LEKE  E ++  ++    ++T+ +   G LE+    + +++ 
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK-AKGNLEKMCRTLEDQL- 1262

Query: 182  FNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVD 241
                                 +LK ++   Q L  + DL          T QR       
Sbjct: 1263 --------------------SELKSKEEEQQRL--INDL----------TAQR------- 1283

Query: 242  SAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL- 300
                 +   + +FS+ L E  + V  L  G    F    E+    LE  +K K    H  
Sbjct: 1284 ---GRLQTESGEFSRQLDEKEALVSQLSRGK-QAFTQQIEELKRQLEEEIKAKNALAHAL 1339

Query: 301  --TSYICFLRKILPYQLKSLEEECESSL-CTSALRARNLELSQ-------DMKKMTAVFE 350
              + + C L +      +  EEE ES      AL   N E++Q       D  + T   E
Sbjct: 1340 QSSRHDCDLLR------EQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393

Query: 351  KLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHE-- 408
            + +  +A     + E    +    +S+        +   D+M D+ +  +  AA++ +  
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453

Query: 409  -----LPTATQKLITTN---DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAAS 460
                 L    QK   T+   +       +L     KI + +  +LD  + +L    K   
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ-LETLKRENKNLQ 1512

Query: 461  GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQ 520
              IS L+ E + +  K+     K  ++   E    + AL       +S E  EG   ++Q
Sbjct: 1513 QEISDLT-EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE---ASLEHEEGKILRIQ 1568

Query: 521  QSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQ-------------LV 567
              L ++   + E +  + E      +L++ + RI + +++T  A+             + 
Sbjct: 1569 LELNQV---KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625

Query: 568  GLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMA 627
            G   E     N A +  A A   L   ++T   G L  T       + S+ED        
Sbjct: 1626 GDLNEMEIQLNHANRMAAEA---LRNYRNTQ--GILKDTQIHLDDALRSQED-------- 1672

Query: 628  RIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDE--- 684
                L  QL + + ++    AE   L   L   E+S++   +E+  AS+ +  L  +   
Sbjct: 1673 ----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728

Query: 685  LTTTKRSYEDQLSMMSDHL 703
            L  TK+  E  +S M   +
Sbjct: 1729 LINTKKKLETDISQMQGEM 1747



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 148/775 (19%), Positives = 292/775 (37%), Gaps = 115/775 (14%)

Query: 23   LAKRVELLQDELALSEPRGKKN--------KKSGESSSQLSQEQKSVFDED------LQK 68
            + +  + ++DELA SE + K+         K+  +   Q+  E + + D +      ++ 
Sbjct: 858  MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917

Query: 69   KIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLT-------RKYME 121
            KI+   ++  +  E  E  + + AEL ++   LE E ++ +  +D L        ++   
Sbjct: 918  KIQLEAKIK-EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 976

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH--EDLSGRLEESLSIINEK 179
            T  K++N   ++    +T+ K  KE +   E  Q  L  L   ED    L ++   + ++
Sbjct: 977  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1036

Query: 180  VPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI---- 235
            V   +    Q   L + L   + +L+        L   Q+ +  + N     ++++    
Sbjct: 1037 VDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQLDEKLKKKE 1090

Query: 236  -QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 294
             +I  + S I+    L  +  + + E  + +  LEE +               E   + K
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI-------------EAERASRAK 1137

Query: 295  TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQT 354
               +         R  L  +L+ + E  E +       +  +E++   KK  A F+K++ 
Sbjct: 1138 AEKQ---------RSDLSRELEEISERLEEA---GGATSAQIEMN---KKREAEFQKMRR 1182

Query: 355  YIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ 414
             +    L        LR  ++  +  +G  +     V + + K  S+      +L +  +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242

Query: 415  ----------KLITTNDCILSSVVA-----------LTNGAGKI---ASFFSNNLDY--- 447
                      K+  T +  LS + +           LT   G++   +  FS  LD    
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302

Query: 448  FIASLSYGPKAASGFISPLSAECMLQYKKKAA---AYMKSLRKPLLESVPYEE-----AL 499
             ++ LS G +A +  I  L  +   + K K A   A   S     L    YEE     A 
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362

Query: 500  ANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA---- 555
              R +  ++TE  +   +    ++++  +LE+ K+      Q A+  +E  N + A    
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422

Query: 556  --DKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPD 613
               +L+N     ++ + + NAA +    +     K + E  Q           S  E   
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482

Query: 614  VESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKL 673
            + +    IKN Y     E   QL+    ++ +   E   L++++A   K    L +  K 
Sbjct: 1483 LGTELFKIKNAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ 1538

Query: 674  ASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNET-------LSKQREEIDTLK 721
              Q    LQ  L   + S E +   +      +N+        ++++ EEID LK
Sbjct: 1539 VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 43/195 (22%), Positives = 94/195 (48%), Gaps = 25/195 (12%)

Query: 3    DQSLRKLQQEMDSLT--FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
            +  + ++Q EM+ +    RN +  K  + + D   ++E    + KK  ++S+ L + +K+
Sbjct: 1737 ETDISQMQGEMEDILQEARNAE-EKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKN 1791

Query: 61   VFD--EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL--- 115
            +    +DLQ +++E E+L ++     +Q + +EA +R     +E+E  ++   V GL   
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALK--GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849

Query: 116  ----------TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDL 165
                      T +  + I +LQ+   KL+ K ++ +++A+E   ++     + + L  +L
Sbjct: 1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909

Query: 166  SGRLEESLSIINEKV 180
                EE   I   +V
Sbjct: 1910 E-EAEERADIAESQV 1923


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 143/746 (19%), Positives = 298/746 (39%), Gaps = 61/746 (8%)

Query: 3    DQSLRKLQQEMDSLTFR-------NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLS 55
            D+ L K + E+ +L  +        +QL K+++ LQ  +   E  G++ +    S ++ +
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARI---EELGEEIEAERASRAK-A 1135

Query: 56   QEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 115
            ++Q+S    +L++  E  E          E +K  EAE +     LE    QH+A+V  L
Sbjct: 1136 EKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             +K+ +++ +L      L+   Q LEKE  E ++ T++     + + +   G LE+    
Sbjct: 1196 RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK-AKGNLEKMCRS 1254

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQD---LVTALLNFHTYTE 232
            + ++V    TK  +   L   L  +R +L+    AG+    + +   LV+ L      + 
Sbjct: 1255 LEDQVSELKTKEEEQQRLINDLTAQRARLQTE--AGEYSRQLDEKDALVSQLSRSKQAST 1312

Query: 233  QRI-----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 287
            Q+I     Q+     A + ++   Q                +EG   L  ++++    V 
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372

Query: 288  ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTA 347
            +   K +T +   T  +   +K L  +L+  EE  E      A+ A+   L +  +++  
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE------AVNAKCASLEKTKQRLQN 1426

Query: 348  VFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH 407
              E L   +              R+N  +    +      F  V+ +  + Y +  A E 
Sbjct: 1427 EVEDLMLDVE-------------RSN--AACAALDKKQRNFDKVLSEWKQKYEETQA-EL 1470

Query: 408  ELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLS 467
            E      + ++T    + +V   +    +     + NL   I+ L+   + A G      
Sbjct: 1471 EASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLT--EQIAEGGKQIHE 1528

Query: 468  AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS 527
             E + +  ++    +++  +    S+ +EE     RI L   + +  + +++ +  E+I 
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI-LRIQLELNQVKSEVDRKIAEKDEEID 1587

Query: 528  KLEQEKEHWMLEAQL---AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDE 584
            +L++     +   Q    A+I+   +  R+  K++   +   + L   N   + +  ++ 
Sbjct: 1588 QLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESL-RNY 1646

Query: 585  ATAKAVLEPIQSTSLIGTLTRTSD--SEVPDVESREDLIKNHYMARIVELTSQLQLADSK 642
               + +L+  Q   L   L    D   ++  VE R +L++    A I EL + L+  +  
Sbjct: 1647 RNTQGILKETQ-LHLDDALRGQEDLKEQLAIVERRANLLQ----AEIEELWATLEQTERS 1701

Query: 643  SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRSYEDQLSMM 699
                  E    S+R+ L      +L    K    ++S+LQ   +E+    R+ E++    
Sbjct: 1702 RKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA 1761

Query: 700  SDHLCSMNETLSKQREEIDTLKMSSK 725
                  M E L K+++    L+   K
Sbjct: 1762 ITDAAMMAEELKKEQDTSAHLERMKK 1787



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 34/163 (20%), Positives = 74/163 (45%), Gaps = 23/163 (14%)

Query: 32   DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLH------IQFFEADE 85
            D+L L+  + +K K + E+  +   E+ +  DE + K  +E + L       +   +A+E
Sbjct: 958  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017

Query: 86   QHKHV----EAELRSRLATLETEAAQHQAV----------VDGLTRKYMETIEKLQNDKA 131
               ++    + +L  ++  LE    Q + +          ++G  +   E+   ++NDK 
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077

Query: 132  KLEVKSQTLEKEAKECRLRTEE---CQLQLKTLHEDLSGRLEE 171
            +L+ K +  E E      + E+    ++QL+   ++L  R+EE
Sbjct: 1078 QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE 1120



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 2/112 (1%)

Query: 605 RTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSK 664
           +T D        R++L +   M  +++  + LQL         A+     ++L   +   
Sbjct: 861 KTKDELAKSEAKRKELEEK--MVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQL 918

Query: 665 EALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREE 716
           EA  +E+   ++    +  ELT  KR  ED+ S +   +  +  TL+K  +E
Sbjct: 919 EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 970



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 21/71 (29%), Positives = 36/71 (50%), Gaps = 1/71 (1%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFD 63
            + LRK ++ +  LT++  +  K V  LQD +   + + K  K+  E + + S    S F 
Sbjct: 1841 KGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKF- 1899

Query: 64   EDLQKKIEENE 74
              LQ ++EE E
Sbjct: 1900 RKLQHELEEAE 1910


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 149/752 (19%), Positives = 279/752 (37%), Gaps = 78/752 (10%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K+  +  LQ +++      +QL K+++ LQ  +   E    +  ++  +S   +++Q+S 
Sbjct: 1087 KEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELE----EEIEAERASRAKAEKQRSD 1142

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
               +L++  E  E          E +K  EAE +     LE    QH+A    L +K+ +
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTL------HEDLSGRLEESLSI 175
            ++ +L      L+   Q LEKE  E ++   +    ++T+       E +   LE+ LS 
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262

Query: 176  INEKVPFNDTKYSQYNALNVPLHNR----RHQLKMRDIAGQALAFVQDLVTALLNFHTYT 231
            I  K        ++ +A    LH        QL  +D     L+  +   T  +      
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIE----- 1317

Query: 232  EQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTV 291
            E + Q+     A  T++   Q                +E    L   +++    V +   
Sbjct: 1318 ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377

Query: 292  KLKTFSEHLTSYICFLRKILPYQLKSLEEECE--SSLCTSALRARNLELSQDMKKMTAVF 349
            K +T +   T  +   +K L  +L+  EE  E  +S C S L      L  +++ +    
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS-LEKTKQRLQNEVEDLMIDV 1436

Query: 350  EKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHEL 409
            E+  +  A +AL   +                      F  V+ +  + Y +  A   EL
Sbjct: 1437 ER--SNAACIALDKKQ--------------------RNFDKVLAEWKQKYEETQA---EL 1471

Query: 410  PTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAE 469
              A+QK             +L+    K+ + +  +LD+ + +L    K     IS L+ +
Sbjct: 1472 -EASQK----------ESRSLSTELFKVKNAYEESLDH-LETLKRENKNLQQEISDLTEQ 1519

Query: 470  CM--------LQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ 521
                      L+  KK   + KS  +  LE           +IL    E  +  ++  ++
Sbjct: 1520 IAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579

Query: 522  SLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAG 581
              EK  +L+Q K + +   +  +  L+ E +   D L+     ++ G   E     N A 
Sbjct: 1580 IAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRI--KKKMEGDLNEMEIQLNHAN 1637

Query: 582  QDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLI-----KNHYMARIVELTSQL 636
            +  A A   L   Q   L  T     D+     + +E L       N   A + EL + L
Sbjct: 1638 RQAAEALRNLRNTQGI-LKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696

Query: 637  QLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRSYE 693
            +  +        E    S+R+ L      +L    K    +IS++Q   +++    R+ E
Sbjct: 1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756

Query: 694  DQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
            ++          M E L K+++    L+   K
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 52/253 (20%), Positives = 105/253 (41%), Gaps = 56/253 (22%)

Query: 487  KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIK 546
            KPLL+S   E+ +AN             + ++ +++ E+++K E +++   LE ++  + 
Sbjct: 841  KPLLKSAETEKEMAN-------------MKEEFEKTKEELAKTEAKRKE--LEEKMVTLM 885

Query: 547  LEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRT 606
             EK + ++                Q  A     A  +E   + +   IQ  + I  +T  
Sbjct: 886  QEKNDLQL----------------QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTER 929

Query: 607  SDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEA 666
            ++ E       E++          ELT++ +  + +      +   L   LA  EK K A
Sbjct: 930  AEDE-------EEI--------NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974

Query: 667  -------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCSMNETLSKQREE 716
                   LTEEM    + I++L  E    + +++   D L M  D + ++ +  +K  ++
Sbjct: 975  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034

Query: 717  IDTLKMSSKGNSK 729
            +D L+ S +   K
Sbjct: 1035 VDDLEGSLEQEKK 1047



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 128/712 (17%), Positives = 255/712 (35%), Gaps = 101/712 (14%)

Query: 32   DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVE 91
            D+L L+  + +K K + E+  +   E+ +  DE + K  +E + L               
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ-------------- 1004

Query: 92   AELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRT 151
                            HQ  +D L  +  + +  L   K KLE +   LE   ++ +   
Sbjct: 1005 --------------EAHQQTLDDLQME-EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC 1049

Query: 152  EECQLQLKTLHEDLSGRLEESLSIINEKVPFND-TKYSQYNALNVPLHNRRHQLKMRDIA 210
             + +   + L  DL    E ++   N+K   N+  K  ++   N+       Q K+ D  
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNL-------QGKIEDEQ 1102

Query: 211  GQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEE 270
              A+   + +           E + +I  ++  I+       K  +   + +   R LEE
Sbjct: 1103 ALAIQLQKKI----------KELQARIEELEEEIEAERASRAKAEK---QRSDLSRELEE 1149

Query: 271  GMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSA 330
                L E+      T  +  +  K  +E       F +     +  +L+ E  ++     
Sbjct: 1150 ISERLEEA---GGATSAQIEMNKKREAE-------FQKMRRDLEESTLQHEATAAALRKK 1199

Query: 331  LRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHD 390
                  EL + +  +  V +KL+   + L +   +         +S +  V  A   F  
Sbjct: 1200 HADSVAELGEQIDSLQRVKQKLEKEKSELKMEIND--------LASNMETVSKAKANFEK 1251

Query: 391  VMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIA 450
            + + +    S+    E E     Q+LI      LS+  A  +      S   +  D  ++
Sbjct: 1252 MCRTLEDQLSEIKTKEEE----QQRLINE----LSAQKARLHTESGEFSRQLDEKDAMVS 1303

Query: 451  SLSYGPKAASGFISPL--------SAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANR 502
             LS G +A +  I  L         A+  L +  ++A +   L +   E     +A   R
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQR 1363

Query: 503  RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA------D 556
             +  +++E  +   +    ++++  +LE+ K+      Q A+  +E  N + A       
Sbjct: 1364 GMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQ 1423

Query: 557  KLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVES 616
            +L+N     ++ + + NAA      +     K + E  Q           S  E   + +
Sbjct: 1424 RLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLST 1483

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
                +KN Y     E    L+    ++ +   E   L++++A   K    L +  K    
Sbjct: 1484 ELFKVKNAY----EESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDH 1539

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNET-------LSKQREEIDTLK 721
              S LQ  L   + S E +   +      +N+        ++++ EE+D LK
Sbjct: 1540 EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK 1591


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 170/835 (20%), Positives = 326/835 (39%), Gaps = 141/835 (16%)

Query: 9    LQQEMDSL-TFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--- 64
            L++E++++ TF       R++L Q+ELA      K      E   + S EQ    ++   
Sbjct: 429  LKKELEAMRTFCESAKQDRLKL-QNELAHKVAECKALALECERVKEDSDEQIKQLEDALK 487

Query: 65   DLQKKIEENE-------------RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAV 111
            D+QK++ E+E             + H+    A   H+  E EL+ +L  L+ +     A 
Sbjct: 488  DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKYEGASAE 546

Query: 112  VDGLTRKYMET---IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH---EDL 165
            V  L  +  +    +E+ + D+ KL  +++ L+KE   C +  E+   ++  +    ++L
Sbjct: 547  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 606

Query: 166  SGRLEESLSIINEKVPFNDTKYSQYNALNVPLH-----NRRHQLKMRDIAGQALAFVQDL 220
            S +L  +LSI  EK  F + K S  N +N          R H+  + +I  + L    + 
Sbjct: 607  SAKL--ALSIPAEK--FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI--RQLKRELEN 660

Query: 221  VTALLNFHTYTEQRIQIFPVDSAIDTIS-PLNQKFSQYLHENASYVRPLEEGMLH---LF 276
            V A L  H   E+  Q   V S ++  S  L +K ++   +N +  + +E+  L    L 
Sbjct: 661  VKAKLAQHVKPEEHEQ---VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLK 717

Query: 277  ESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNL 336
            E     T+ +    V LK   +   S+   +  +    L   ++  E  L    L   N 
Sbjct: 718  EQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEND 777

Query: 337  ELSQDMKKMTAVF---EKLQTYIALLALPSTEPDGLL--------------------RTN 373
             LS+D+ ++  VF   EK +  I  L     E    L                     TN
Sbjct: 778  SLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTN 837

Query: 374  YSSVLTNVGAALHGFHDV--------------MKDISKHY----SQKAAIEHELPTATQK 415
               +++N    +    +V              + D+ K +     +   I+ +     + 
Sbjct: 838  LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRN 897

Query: 416  LITTNDCILSSVVALTNGAGKIASFFSN--NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
            L  T + I +  ++L     K++S   +   +    A +    +     I  L AE   Q
Sbjct: 898  LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ 957

Query: 474  YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ---SLEKISKLE 530
             KK+     + ++      V +EE    R+   +  E ++ L++Q Q+   S E++ K +
Sbjct: 958  -KKELDTIQECIKVKYAPIVSFEE--CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1014

Query: 531  QE-----KEHWMLEAQL----AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAG 581
            QE     KE + L+  L      I+   E +R   +  +  + QL  L+Q+   V N   
Sbjct: 1015 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1074

Query: 582  Q-DEATAKAVLEPIQSTSL----------IGTLTRTSDSEVPDVESREDLIKNHYMARIV 630
            +  E  AK   E +   +L          +  L ++ +  + +++     ++  Y     
Sbjct: 1075 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1134

Query: 631  ELTSQLQLADSK-------SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQD 683
             +T   QL +++       + H   +  A  K + + + S     EE +   + +S+LQ 
Sbjct: 1135 TVTKLHQLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1193

Query: 684  ELTTTKRS---------------------YEDQLSMMSDHLCSMNETLSKQREEI 717
            E+  TK++                      E Q+S +++ L ++N    +  EE+
Sbjct: 1194 EVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV 1248



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 151/775 (19%), Positives = 291/775 (37%), Gaps = 123/775 (15%)

Query: 6    LRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDED 65
            +R+L++E++++     +LA+ V+  + E    + + +  +KSGE   ++++   ++ ++ 
Sbjct: 651  IRQLKRELENV---KAKLAQHVKPEEHE----QVKSRLEQKSGELGKKITE--LTLKNQT 701

Query: 66   LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATL---ETEAAQHQAVVDGLTRKYMET 122
            LQK+IE   ++++      EQ  ++  E+++    L   E     H A++D L RK ++ 
Sbjct: 702  LQKEIE---KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV 758

Query: 123  IEKLQNDKAKLE--------------------VKSQTLEKEAKECRLRTEECQLQLKTLH 162
             +K    K ++E                    V  +  EKE    +    E + QL  L 
Sbjct: 759  TQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELK 818

Query: 163  EDLSGRLEESLSIINEKVPFNDTKYSQY----------NALNVPLHNRRHQL-----KMR 207
            +      E+  ++ +E         +QY            LN  L     +L     K  
Sbjct: 819  KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 878

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID--TISPLNQKFSQYLHENASYV 265
            DI  Q    ++D    L      T+ +I+   +  A     +S L+Q   +    NA  +
Sbjct: 879  DI-NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 937

Query: 266  RPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPY--------QLKS 317
                +G         ++ +  L   +K +   E  T   C   K  P         + K+
Sbjct: 938  ANYRKG---------QEEIVTLHAEIKAQK-KELDTIQECIKVKYAPIVSFEECERKFKA 987

Query: 318  LEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSV 377
             E+E +  L     +    E  +++KK     +KL+  I  L     +   L+  ++  +
Sbjct: 988  TEKELKDQLSEQTQKYSVSE--EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH-EM 1044

Query: 378  LTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKI 437
               +       +  +KD+S+ Y+       E+    +KL+  N    S ++A+ N     
Sbjct: 1045 ERALSRKTDELNKQLKDLSQKYT-------EVKNVKEKLVEENAKQTSEILAVQN----- 1092

Query: 438  ASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ---YKKKAAAY---------MKSL 485
                       +  +    K+ +G I  L  E       Y+K+              K+ 
Sbjct: 1093 ---LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1149

Query: 486  RKPLLESVPYEEALANR-RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAK 544
              PL E +  +EA      I+ +S   +E   ++ Q  +E++SKL+ E ++     + A 
Sbjct: 1150 SVPLAEHLQIKEAFEKEVGIIKASLREKE---EESQNKMEEVSKLQSEVQN----TKQAL 1202

Query: 545  IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVL----EPIQSTSLI 600
             KLE        K K T S     ++  N  ++N   + E   + VL    + I +    
Sbjct: 1203 KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1262

Query: 601  GTLTRTSDSEVPDVESRED---LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL 657
              L  + + E+ D + R D           RI E   Q++  D+K      +   L + L
Sbjct: 1263 ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1322

Query: 658  ALAEKSKEALTEEMKLASQNISRLQ-------DELTTTKRSYEDQLSMMSDHLCS 705
                +         K  SQ I  LQ        +L    R +++ +++   HL S
Sbjct: 1323 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1377



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 78/434 (17%), Positives = 185/434 (42%), Gaps = 55/434 (12%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQK-SV 61
            ++ L  ++++ + +    +++  + E+L+  L        +N+   E  S    E K S 
Sbjct: 867  NRELLDVKKKFEDINQEFVKIKDKNEILKRNL-----ENTQNQIKAEYISLAEHEAKMSS 921

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEA----AQHQAVV--DGL 115
              + ++K  + N  +   + +  E+   + AE++++   L+T       ++  +V  +  
Sbjct: 922  LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC 981

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             RK+  T ++L++  ++   K    E+E K+ +   ++ + ++ TL +DL          
Sbjct: 982  ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL---------- 1031

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI 235
              +K    +  +    AL+        QLK  D++ Q    V+++   L+  +   +Q  
Sbjct: 1032 -RDKTVLIEKSHEMERALSRKTDELNKQLK--DLS-QKYTEVKNVKEKLVEEN--AKQTS 1085

Query: 236  QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV-------LE 288
            +I  V           Q   Q  H     V  L++ +    E++ E+  ++        +
Sbjct: 1086 EILAV-----------QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1134

Query: 289  TTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAV 348
            T  KL    E+  +    L + L  Q+K   E+ E  +  ++LR +  E    M++++ +
Sbjct: 1135 TVTKLHQLLENQKNSSVPLAEHL--QIKEAFEK-EVGIIKASLREKEEESQNKMEEVSKL 1191

Query: 349  FEKLQ-TYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH 407
              ++Q T  AL  L + E   L  + Y +  +++   +   ++ + ++++ Y +   +  
Sbjct: 1192 QSEVQNTKQALKKLETREVVDL--SKYKATKSDLETQISSLNEKLANLNRKYEE---VCE 1246

Query: 408  ELPTATQKLITTND 421
            E+  A +K I+  D
Sbjct: 1247 EVLHAKKKEISAKD 1260


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 170/835 (20%), Positives = 326/835 (39%), Gaps = 141/835 (16%)

Query: 9    LQQEMDSL-TFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--- 64
            L++E++++ TF       R++L Q+ELA      K      E   + S EQ    ++   
Sbjct: 442  LKKELEAMRTFCESAKQDRLKL-QNELAHKVAECKALALECERVKEDSDEQIKQLEDALK 500

Query: 65   DLQKKIEENE-------------RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAV 111
            D+QK++ E+E             + H+    A   H+  E EL+ +L  L+ +     A 
Sbjct: 501  DVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKYEGASAE 559

Query: 112  VDGLTRKYMET---IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH---EDL 165
            V  L  +  +    +E+ + D+ KL  +++ L+KE   C +  E+   ++  +    ++L
Sbjct: 560  VGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKEL 619

Query: 166  SGRLEESLSIINEKVPFNDTKYSQYNALNVPLH-----NRRHQLKMRDIAGQALAFVQDL 220
            S +L  +LSI  EK  F + K S  N +N          R H+  + +I  + L    + 
Sbjct: 620  SAKL--ALSIPAEK--FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI--RQLKRELEN 673

Query: 221  VTALLNFHTYTEQRIQIFPVDSAIDTIS-PLNQKFSQYLHENASYVRPLEEGMLH---LF 276
            V A L  H   E+  Q   V S ++  S  L +K ++   +N +  + +E+  L    L 
Sbjct: 674  VKAKLAQHVKPEEHEQ---VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLK 730

Query: 277  ESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNL 336
            E     T+ +    V LK   +   S+   +  +    L   ++  E  L    L   N 
Sbjct: 731  EQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEND 790

Query: 337  ELSQDMKKMTAVF---EKLQTYIALLALPSTEPDGLL--------------------RTN 373
             LS+D+ ++  VF   EK +  I  L     E    L                     TN
Sbjct: 791  SLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTN 850

Query: 374  YSSVLTNVGAALHGFHDV--------------MKDISKHY----SQKAAIEHELPTATQK 415
               +++N    +    +V              + D+ K +     +   I+ +     + 
Sbjct: 851  LKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRN 910

Query: 416  LITTNDCILSSVVALTNGAGKIASFFSN--NLDYFIASLSYGPKAASGFISPLSAECMLQ 473
            L  T + I +  ++L     K++S   +   +    A +    +     I  L AE   Q
Sbjct: 911  LENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ 970

Query: 474  YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ---SLEKISKLE 530
             KK+     + ++      V +EE    R+   +  E ++ L++Q Q+   S E++ K +
Sbjct: 971  -KKELDTIQECIKVKYAPIVSFEE--CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNK 1027

Query: 531  QE-----KEHWMLEAQL----AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAG 581
            QE     KE + L+  L      I+   E +R   +  +  + QL  L+Q+   V N   
Sbjct: 1028 QENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1087

Query: 582  Q-DEATAKAVLEPIQSTSL----------IGTLTRTSDSEVPDVESREDLIKNHYMARIV 630
            +  E  AK   E +   +L          +  L ++ +  + +++     ++  Y     
Sbjct: 1088 KLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1147

Query: 631  ELTSQLQLADSK-------SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQD 683
             +T   QL +++       + H   +  A  K + + + S     EE +   + +S+LQ 
Sbjct: 1148 TVTKLHQLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1206

Query: 684  ELTTTKRS---------------------YEDQLSMMSDHLCSMNETLSKQREEI 717
            E+  TK++                      E Q+S +++ L ++N    +  EE+
Sbjct: 1207 EVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV 1261



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 151/775 (19%), Positives = 291/775 (37%), Gaps = 123/775 (15%)

Query: 6    LRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDED 65
            +R+L++E++++     +LA+ V+  + E    + + +  +KSGE   ++++   ++ ++ 
Sbjct: 664  IRQLKRELENV---KAKLAQHVKPEEHE----QVKSRLEQKSGELGKKITE--LTLKNQT 714

Query: 66   LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATL---ETEAAQHQAVVDGLTRKYMET 122
            LQK+IE   ++++      EQ  ++  E+++    L   E     H A++D L RK ++ 
Sbjct: 715  LQKEIE---KVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDV 771

Query: 123  IEKLQNDKAKLE--------------------VKSQTLEKEAKECRLRTEECQLQLKTLH 162
             +K    K ++E                    V  +  EKE    +    E + QL  L 
Sbjct: 772  TQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELK 831

Query: 163  EDLSGRLEESLSIINEKVPFNDTKYSQY----------NALNVPLHNRRHQL-----KMR 207
            +      E+  ++ +E         +QY            LN  L     +L     K  
Sbjct: 832  KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFE 891

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID--TISPLNQKFSQYLHENASYV 265
            DI  Q    ++D    L      T+ +I+   +  A     +S L+Q   +    NA  +
Sbjct: 892  DI-NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950

Query: 266  RPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPY--------QLKS 317
                +G         ++ +  L   +K +   E  T   C   K  P         + K+
Sbjct: 951  ANYRKG---------QEEIVTLHAEIKAQK-KELDTIQECIKVKYAPIVSFEECERKFKA 1000

Query: 318  LEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSV 377
             E+E +  L     +    E  +++KK     +KL+  I  L     +   L+  ++  +
Sbjct: 1001 TEKELKDQLSEQTQKYSVSE--EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH-EM 1057

Query: 378  LTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKI 437
               +       +  +KD+S+ Y+       E+    +KL+  N    S ++A+ N     
Sbjct: 1058 ERALSRKTDELNKQLKDLSQKYT-------EVKNVKEKLVEENAKQTSEILAVQN----- 1105

Query: 438  ASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ---YKKKAAAY---------MKSL 485
                       +  +    K+ +G I  L  E       Y+K+              K+ 
Sbjct: 1106 ---LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNS 1162

Query: 486  RKPLLESVPYEEALANR-RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAK 544
              PL E +  +EA      I+ +S   +E   ++ Q  +E++SKL+ E ++     + A 
Sbjct: 1163 SVPLAEHLQIKEAFEKEVGIIKASLREKE---EESQNKMEEVSKLQSEVQN----TKQAL 1215

Query: 545  IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVL----EPIQSTSLI 600
             KLE        K K T S     ++  N  ++N   + E   + VL    + I +    
Sbjct: 1216 KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1275

Query: 601  GTLTRTSDSEVPDVESRED---LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL 657
              L  + + E+ D + R D           RI E   Q++  D+K      +   L + L
Sbjct: 1276 ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1335

Query: 658  ALAEKSKEALTEEMKLASQNISRLQ-------DELTTTKRSYEDQLSMMSDHLCS 705
                +         K  SQ I  LQ        +L    R +++ +++   HL S
Sbjct: 1336 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1390



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 78/434 (17%), Positives = 185/434 (42%), Gaps = 55/434 (12%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQK-SV 61
            ++ L  ++++ + +    +++  + E+L+  L        +N+   E  S    E K S 
Sbjct: 880  NRELLDVKKKFEDINQEFVKIKDKNEILKRNL-----ENTQNQIKAEYISLAEHEAKMSS 934

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEA----AQHQAVV--DGL 115
              + ++K  + N  +   + +  E+   + AE++++   L+T       ++  +V  +  
Sbjct: 935  LSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEEC 994

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             RK+  T ++L++  ++   K    E+E K+ +   ++ + ++ TL +DL          
Sbjct: 995  ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDL---------- 1044

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI 235
              +K    +  +    AL+        QLK  D++ Q    V+++   L+  +   +Q  
Sbjct: 1045 -RDKTVLIEKSHEMERALSRKTDELNKQLK--DLS-QKYTEVKNVKEKLVEEN--AKQTS 1098

Query: 236  QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV-------LE 288
            +I  V           Q   Q  H     V  L++ +    E++ E+  ++        +
Sbjct: 1099 EILAV-----------QNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQ 1147

Query: 289  TTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAV 348
            T  KL    E+  +    L + L  Q+K   E+ E  +  ++LR +  E    M++++ +
Sbjct: 1148 TVTKLHQLLENQKNSSVPLAEHL--QIKEAFEK-EVGIIKASLREKEEESQNKMEEVSKL 1204

Query: 349  FEKLQ-TYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH 407
              ++Q T  AL  L + E   L  + Y +  +++   +   ++ + ++++ Y +   +  
Sbjct: 1205 QSEVQNTKQALKKLETREVVDL--SKYKATKSDLETQISSLNEKLANLNRKYEE---VCE 1259

Query: 408  ELPTATQKLITTND 421
            E+  A +K I+  D
Sbjct: 1260 EVLHAKKKEISAKD 1273


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 155/773 (20%), Positives = 296/773 (38%), Gaps = 116/773 (15%)

Query: 8    KLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV------ 61
            KLQ E + L  +   + ++   ++DE  L+    KK K++     +L +E ++       
Sbjct: 1075 KLQLE-EKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK 1133

Query: 62   ---FDEDLQKKIEE-NERLHIQFFEAD---EQHKHVEAELRSRLATLETEAAQHQAVVDG 114
                  DL +++EE +ERL           E +K  EAE +     LE    QH+A    
Sbjct: 1134 VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA 1193

Query: 115  LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLS 174
            L +K+ +++ +L      L+   Q LEKE  E +L             +D++  +E+ + 
Sbjct: 1194 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL-----------DDVTSNMEQII- 1241

Query: 175  IINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQR 234
                K   N  K S                  R +  QA  +   L  A  + + +T QR
Sbjct: 1242 ----KAKANLEKVS------------------RTLEDQANEYRVKLEEAQRSLNDFTTQR 1279

Query: 235  IQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 294
             +          +   N + ++ L E  + +  L  G L   + + ED    LE   K K
Sbjct: 1280 AK----------LQTENGELARQLEEKEALISQLTRGKLSYTQQM-EDLKRQLEEEGKAK 1328

Query: 295  TFSEHL---TSYICFLRKILPYQLKSLEEECESSL-CTSALRARNLELSQ-------DMK 343
                H      + C L +      +  EEE E+       L   N E++Q       D  
Sbjct: 1329 NALAHALQSARHDCDLLR------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAI 1382

Query: 344  KMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKA 403
            + T   E+ +  +A     + E    +    SS+        +   D+M D+ +  +  A
Sbjct: 1383 QRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1442

Query: 404  AIEHE-------LPTATQKLITTNDCILSS---VVALTNGAGKIASFFSNNLDYFIASLS 453
            A++ +       L    QK   +   + SS     +L+    K+ + +  +L++ + +  
Sbjct: 1443 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH-LETFK 1501

Query: 454  YGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPL-LESVPYEEALANR---------R 503
               K     IS L+ +  L    K    ++ +RK L +E +  + AL            +
Sbjct: 1502 RENKNLQEEISDLTEQ--LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGK 1559

Query: 504  ILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKE----NQRIADKLK 559
            IL +  E  +  A+  ++  EK  ++EQ K +        +  L+ E    N+ +  K K
Sbjct: 1560 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKK 1619

Query: 560  NTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL-IGTLTRTSD---SEVPDVE 615
              G    + +   +A  +  A + +   K++   ++ T + +    R +D     +  VE
Sbjct: 1620 MEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1677

Query: 616  SREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLAS 675
             R +L++    A + EL + ++  +        E    S+R+ L      +L  + K   
Sbjct: 1678 RRNNLLQ----AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKME 1733

Query: 676  QNISRLQDELTTTK---RSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
             ++++LQ E+       R+ E++          M E L K+++    L+   K
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 148/774 (19%), Positives = 300/774 (38%), Gaps = 91/774 (11%)

Query: 5    SLRKLQQEMDSLTFRNLQLAKR---VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            S+ +L +++D+L     +L K     +L  D++  +  +  K K + E  S+  ++Q + 
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
            +    + K+EE +R    F           A+L++    L  +  + +A++  LTR  + 
Sbjct: 1261 Y----RVKLEEAQRSLNDFTTQ-------RAKLQTENGELARQLEEKEALISQLTRGKLS 1309

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGR--LEESLSIINEK 179
              +++++ K +LE + +     A   +    +C L  +   E+   +  L+  LS  N +
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369

Query: 180  VPFNDTKYSQYNAL--NVPLHNRRHQLKMR-DIAGQALAFVQDLVTALLNFHTYTEQRIQ 236
            V    TKY + +A+     L   + +L  R   A +A+  V    ++L       +  I+
Sbjct: 1370 VAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428

Query: 237  IFPVD-----SAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTV 291
               VD     +A   +    + F + L   A + +  EE    L ES  ++  ++     
Sbjct: 1429 DLMVDVERSNAAAAALDKKQRNFDKIL---AEWKQKYEESQSEL-ESSQKEARSLSTELF 1484

Query: 292  KLK-TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFE 350
            KLK  + E L     F R     + K+L+EE            +N+   + ++K   V E
Sbjct: 1485 KLKNAYEESLEHLETFKR-----ENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV-E 1538

Query: 351  KLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELP 410
            KL+   AL      E +  L      +L     A   F+ +  +I +  ++K     +  
Sbjct: 1539 KLELQSAL-----EEAEASLEHEEGKIL----RAQLEFNQIKAEIERKLAEKDEEMEQAK 1589

Query: 411  TATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC 470
               Q+++ +    L +     N   ++      +L+     LS+  +        ++AE 
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR--------MAAEA 1641

Query: 471  MLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQ----QVQQSLEKI 526
              Q  K   + +K  +  L ++V   + L      ++  E R  L Q    +++  +E+ 
Sbjct: 1642 QKQV-KSLQSLLKDTQIQLDDAVRANDDLKEN---IAIVERRNNLLQAELEELRAVVEQT 1697

Query: 527  SKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEAT 586
             +  +  E  ++E       L  +N  + ++ K   S      ++   AV      +E  
Sbjct: 1698 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKA 1757

Query: 587  AKAV---------LEPIQSTSL-IGTLTRTSDSEVPDVESREDLIKNHYM---------- 626
             KA+         L+  Q TS  +  + +  +  + D++ R D  +   +          
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1817

Query: 627  -ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDEL 685
             AR+ EL  +L+    ++       R   +R+    K     TEE K     +  L D+L
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRKSERRI----KELTYQTEEDKKNLLRLQDLVDKL 1873

Query: 686  TTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK-----MSSKGNSKKNKSR 734
                ++Y+ Q     +   +      K + E+D  +       S+ N  + KSR
Sbjct: 1874 QLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 53/247 (21%), Positives = 101/247 (40%), Gaps = 27/247 (10%)

Query: 487  KPLLESVPYEEALANRRI----LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQL 542
            KPLL+S   E+ +A  +     +  + E  E   ++++   EK+  L QEK    L+ Q 
Sbjct: 839  KPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELE---EKMVSLLQEKNDLQLQVQA 895

Query: 543  AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGT 602
             +  L    +R    +KN    QL    +E     N   +DE    A L           
Sbjct: 896  EQDNLNDAEERCDQLIKN--KIQLEAKVKE----MNERLEDEEEMNAELT---------A 940

Query: 603  LTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEK 662
              R  + E  +++   D ++      + ++  +    ++K  +   E   L + +A   K
Sbjct: 941  KKRKLEDECSELKKDIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 996

Query: 663  SKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKM 722
             K+AL E  + A  ++   +D++ +  +S + +L    D L    E   K R +++  K 
Sbjct: 997  EKKALQEAHQQALDDLQVEEDKVNSLSKS-KVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1055

Query: 723  SSKGNSK 729
              +G+ K
Sbjct: 1056 KLEGDLK 1062



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 152/793 (19%), Positives = 282/793 (35%), Gaps = 155/793 (19%)

Query: 10   QQEMDS-LTFRNLQLAKRVELLQ---DELALSEPRGKKNKKSGESSSQLSQEQKSVFDED 65
            ++EM++ LT +  +L      L+   D+L L+  + +K K + E+  +   E+ +  DE 
Sbjct: 931  EEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 990

Query: 66   LQKKIEENERLH------IQFFEADEQH----KHVEAELRSRLATLETEAAQHQAV---- 111
            + K  +E + L       +   + +E         + +L  ++  LE    Q + V    
Sbjct: 991  IAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050

Query: 112  ------VDGLTRKYMETIEKLQNDKAKLEVK---------------------SQTLEKEA 144
                  ++G  +   E+I  L+NDK +LE K                     +  L+K+ 
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110

Query: 145  KECRLRTEECQLQLKT----------LHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN 194
            KE + R EE + +L+           L  DLS  LEE    + E       +        
Sbjct: 1111 KENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1170

Query: 195  VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 254
                  R  L+   +  +A A       AL   H  +     +  +   ID +  + QK 
Sbjct: 1171 AEFQKMRRDLEEATLQHEATA------AALRKKHADS-----VAELGEQIDNLQRVKQKL 1219

Query: 255  SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 314
             +   E               F+   +D  + +E  +K K   E ++             
Sbjct: 1220 EKEKSE---------------FKLELDDVTSNMEQIIKAKANLEKVS------------- 1251

Query: 315  LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 374
             ++LE++       +  R +  E  + +   T    KLQT    LA    E + L+    
Sbjct: 1252 -RTLEDQ------ANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI---- 1300

Query: 375  SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 434
             S LT        +   M+D+ +   ++   ++ L  A Q      D +       T   
Sbjct: 1301 -SQLTR---GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAK 1356

Query: 435  GKIASFFSN-NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESV 493
             ++    S  N +       Y   A             +Q  ++     K L + L ++ 
Sbjct: 1357 AELQRVLSKANSEVAQWRTKYETDA-------------IQRTEELEEAKKKLAQRLQDAE 1403

Query: 494  PYEEALANRRILLSSTESR-----EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLE 548
               EA+  +   L  T+ R     E L   V++S    + L++++ ++       K K E
Sbjct: 1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463

Query: 549  KENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSD 608
            +    +    K   S        +NA   +   +   T K   + +Q    I  LT    
Sbjct: 1464 ESQSELESSQKEARSLSTELFKLKNAYEESL--EHLETFKRENKNLQEE--ISDLTEQLG 1519

Query: 609  SEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL------ALAEK 662
                +V   E + K   + ++ EL S L+ A++   H   E + L  +L      A  E+
Sbjct: 1520 EGGKNVHELEKVRKQLEVEKL-ELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIER 1576

Query: 663  SKEALTEEMKLASQNISRLQDELTTT--------------KRSYEDQLSMMSDHLCSMNE 708
                  EEM+ A +N  R+ D L T+              K+  E  L+ M   L   N 
Sbjct: 1577 KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANR 1636

Query: 709  TLSKQREEIDTLK 721
              ++ ++++ +L+
Sbjct: 1637 MAAEAQKQVKSLQ 1649


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 158/790 (20%), Positives = 306/790 (38%), Gaps = 93/790 (11%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFD 63
            + +  L+QE   L   N +L K ++  ++     E   K+N +  E + +L +  +S+  
Sbjct: 656  EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715

Query: 64   EDLQ--------KKIE-ENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 114
              ++        K++E E E+L           K  E  L      L+ E  + Q  ++ 
Sbjct: 716  ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLEN 774

Query: 115  LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRL---RTEECQLQLKTLHEDLS----- 166
              +K    I++L+++   LE+++QTL+K  +E ++   R E+ + + K+L ++ S     
Sbjct: 775  SNKK----IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830

Query: 167  -GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALL 225
              +LE+    + ++    DT   +    NV + N   + K      + +   ++    L 
Sbjct: 831  KKQLEKENKRLRQQAEIKDTTLEEN---NVKIGNLEKENK---TLSKEIGIYKESCVRLK 884

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                  ++ ++   +D  I T+  L +       +       LE+ + H  E I  +   
Sbjct: 885  ELEKENKELVKRATID--IKTLVTLREDLVSEKLKTQQMNNDLEK-LTHELEKIGLNKER 941

Query: 286  VL----ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQD 341
            +L     T  + K     L S +    +I   ++ +LE   E S         N +L Q+
Sbjct: 942  LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES------TNYNQQLRQE 995

Query: 342  MKKMTAVFEKL-QTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYS 400
            +K +   +E L Q       + S+ P       +          L    D + ++ ++ +
Sbjct: 996  LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055

Query: 401  QKAAIEHELPTATQKLITTNDCILSSVVAL-----------TNGAGKIASFFSNNLDYFI 449
               A +  L T  ++L T N+ + + ++AL           T    + A     N     
Sbjct: 1056 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115

Query: 450  ASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRIL-LSS 508
             S S   + A   I   S E   +   K    +KSL   L++     E L  R+     S
Sbjct: 1116 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1175

Query: 509  TESREGLAQQVQQSLE-KISKLEQE-----KEHWMLEAQLAKIKLEKENQRIADKLKNTG 562
              S+ G  +   ++LE +   LE       K+   LE     +K+E+E   + +K   T 
Sbjct: 1176 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1235

Query: 563  SAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIK 622
            +A+   L  EN  +++T  Q           ++ T ++    +T    +  + +   L +
Sbjct: 1236 AAEYKKLCGENDRLNHTYSQ----------LLKETEVL----QTDHKNLKSLLNNSKLEQ 1281

Query: 623  NHYMARIVELTSQLQLADSKSVHFYAECRALSK-RLALAEKSKEALTEEMKLASQNISRL 681
                A   +L  Q Q  D  S     +C  LS+ +  L E+++  L +   L  QN + L
Sbjct: 1282 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1341

Query: 682  QDELTT------TKRSYEDQLSMMSDHLCSMNETLSKQREEID-----------TLKMSS 724
            +  + +       +R Y D+L+ +      + E +  Q +  D           TLKM  
Sbjct: 1342 EQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRK 1401

Query: 725  KGNSKKNKSR 734
               SKK+ +R
Sbjct: 1402 LIKSKKDINR 1411



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 144/743 (19%), Positives = 293/743 (39%), Gaps = 85/743 (11%)

Query: 6   LRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQE-----QKS 60
           +R+L+QE++  T + L   + +E ++ EL   +           S+     E     +K+
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319

Query: 61  VFDEDLQKKIEE-NERLH-IQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRK 118
           V  + L+ ++    ERLH I+F++A      VE         LET+      +    TR 
Sbjct: 320 VRVDKLESEVSRYKERLHDIEFYKA-----RVEELKEDNQVLLETKTMLEDQLEG--TRA 372

Query: 119 YMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINE 178
             + + +L+ +  +L+ K   +E E    R + EE   +  TL       ++ESL +  E
Sbjct: 373 RSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWE 432

Query: 179 KVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIF 238
               + T          P  +  H+  + ++    L  ++    +L    T  E R  + 
Sbjct: 433 LEQISRTS----ELSEAPQKSLGHE--VNELTSSRLLKLEMENQSLTK--TVEELRTTVD 484

Query: 239 PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSE 298
            V+     I  + +K +Q L +    V  LE  ++   +S+ ++   + +  +K K    
Sbjct: 485 SVEGNASKILKM-EKENQRLSKK---VEILENEIVQEKQSL-QNCQNLSKDLMKEKA--- 536

Query: 299 HLTSYICFLRKILPYQLKSLEEECES-SLCTSALRARNLELSQDMKKMTAVFEKLQTYIA 357
            L   I  LR+    Q+K LE+E E  +   S+LR R+ ++S + +      E       
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS-QISAEARVKDIEKE------- 588

Query: 358 LLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLI 417
                    + +L  +     + +         + K++ +HY +K     EL      L 
Sbjct: 589 ---------NKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638

Query: 418 TTNDCILSSVVALTNGAGKIASFFSNN-------------LDYFIASLSYGPKAASGFIS 464
             N+ +   +  L     KI +    N             LD F  +L++  ++     S
Sbjct: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF-KNLTFQLESLEKENS 697

Query: 465 PLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLE 524
            L  E +   +   +    S++   L+       L N+ +     + ++GL + ++ S +
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQ-------LENKELESEKEQLKKGL-ELLKASFK 749

Query: 525 KISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDE 584
           K  +LE   +   +E Q  +  LE  N++I         ++L  L  EN  +     + +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQL-----ESELQDLEMENQTLQKNLEELK 804

Query: 585 ATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSV 644
            ++K + +  +    +   T   + +   +E     ++    A I + T  L+  + K  
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEIKDTT--LEENNVKIG 860

Query: 645 HFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLC 704
           +   E + LSK + + ++S   L E  K   + + R   ++ T     ED   ++S+ L 
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED---LVSEKLK 917

Query: 705 S--MNETLSKQREEIDTLKMSSK 725
           +  MN  L K   E++ + ++ +
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKE 940



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 125/680 (18%), Positives = 266/680 (39%), Gaps = 110/680 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            ++ +++L+ E+  L   N  L K +E L+      E   K+NK   + +SQL +++K + 
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835

Query: 63   DED----LQKKIEEN--ERLHIQFFEADEQHKHVEAELR------SRLATLETEAAQ--H 108
             E+     Q +I++   E  +++    ++++K +  E+        RL  LE E  +   
Sbjct: 836  KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895

Query: 109  QAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQL------------ 156
            +A +D      ++T+  L+ D    ++K+Q +  + ++     E+  L            
Sbjct: 896  RATID------IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949

Query: 157  --QLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQAL 214
              + K L   L   L++SL I  EK+   + +  +    N  L                 
Sbjct: 950  DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR---------------- 993

Query: 215  AFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLH 274
               Q+L T   N+    +++ +    +  + +  P++ + +++  E+    R L +    
Sbjct: 994  ---QELKTVKKNYEALKQRQDE----ERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1046

Query: 275  LFESITEDTVTV------LETTVK-LKTFSEHLTSYICFLRKILPYQLKSLEEECESSLC 327
            L E +  +  T+      L+T +K L+T + +L + I  L++    Q  SL+E+      
Sbjct: 1047 LIE-VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR----QTVSLQEQ------ 1095

Query: 328  TSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHG 387
             + L+ +N +L  +   + +    L    A L +  +     L     SV+         
Sbjct: 1096 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS----LENENESVIKEREDLKSL 1151

Query: 388  FHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDY 447
            +  ++KD      +K  + HE   +  + + +    L S       A K       +L+ 
Sbjct: 1152 YDSLIKD-----HEKLELLHERQASEYESLISKHGTLKS-------AHKNLEVEHRDLED 1199

Query: 448  FIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLS 507
                L        G +  L  E ML+ +++         K LLE+  +E   A  + L  
Sbjct: 1200 RYNQL----LKQKGQLEDL--EKMLKVEQE---------KMLLENKNHETVAAEYKKLCG 1244

Query: 508  STESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLV 567
              +       Q+ +  E +    +  +  +  ++L + +LE E  ++ ++ +        
Sbjct: 1245 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS-T 1303

Query: 568  GLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMA 627
             L  +   +S   G  E   + +L+ IQ+  L        + E  D+   E   +  Y+ 
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE---QRQYID 1360

Query: 628  RIVELTSQLQLADSKSVHFY 647
            ++ EL  Q +  + K +  Y
Sbjct: 1361 KLNELRRQKEKLEEKIMDQY 1380



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 44/213 (20%), Positives = 103/213 (48%), Gaps = 26/213 (12%)

Query: 1   MKDQSLRKLQQEMDS--------------LTFRNLQLAKRVELLQDELALSEPRGKKNKK 46
           M++QSL K  +E+ +              +   N +L+K+VE+L++E+     + K++ +
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV----QEKQSLQ 522

Query: 47  SGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAA 106
           + ++ S+   ++K+  ++ ++   E +ER  I+  E + +H +       + + +  EA 
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQRSQISAEAR 581

Query: 107 QHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEA---KECRLRTEECQLQLKTLHE 163
                ++   +   E+I++  +  +K+E + + ++KE    KE   R EE + +L  L +
Sbjct: 582 VKD--IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639

Query: 164 --DLSGRLEESLSIINEKVPFNDTKYSQYNALN 194
             +L  +   +L I  EK+   + + S+    N
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELEREN 672



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 57/242 (23%), Positives = 99/242 (40%), Gaps = 44/242 (18%)

Query: 509 TESREGLAQQVQQSLEK-ISKLEQEKEHWMLEAQLAKI-KLEKENQRIADKLKNTGSAQL 566
           T SR    +   QSL K + +L    +   +E   +KI K+EKENQR++ K++   +   
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDS--VEGNASKILKMEKENQRLSKKVEILENE-- 513

Query: 567 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             + QE  ++ N     +   K   E  Q    I TL   S+ ++  +E   +    H  
Sbjct: 514 --IVQEKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENSERQIKILEQENE----HLN 564

Query: 627 ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
             +  L  + Q++        AE R         EK  + L E +K  S  +S+++ E  
Sbjct: 565 QTVSSLRQRSQIS--------AEARVKD-----IEKENKILHESIKETSSKLSKIEFEKR 611

Query: 687 TTKRSYE---------DQLSMMSDHLCSMNETLSKQ-------REEIDTLKMSSKGNSKK 730
             K+  E         ++L     HL   NE L K+        E+I+ L+  +    ++
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671

Query: 731 NK 732
           N+
Sbjct: 672 NR 673


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 156/775 (20%), Positives = 307/775 (39%), Gaps = 97/775 (12%)

Query: 3    DQSLRKLQQEMDSL--TFRNLQLAKRVELLQDELALSEPRGKKNKKSGESS----SQLSQ 56
            +++ RKL+ EMD    T       +R+ L Q+   + +      KKS E       +L +
Sbjct: 427  EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486

Query: 57   EQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLT 116
            ++ +  +++L KK++  ER      E  EQ K    + +S    +  E  Q +++     
Sbjct: 487  KELARKEQELTKKLQTRER------EFQEQMKVALEKSQSEYLKISQEKEQQESLA---- 536

Query: 117  RKYMETIEKLQNDKAKL----EVKSQTLEKEAKECRLRTEECQLQL-KTLHEDLSGRLEE 171
                  +E+L+  K  +    E K + L++EA+  R R  E +  L K+L E+ +   + 
Sbjct: 537  ------LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL 590

Query: 172  SLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYT 231
            ++ +  EK   N             L + +HQ        +     Q   T +       
Sbjct: 591  AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL-WTEKLQVLKQQYQTEMEKLREKC 649

Query: 232  EQRIQIFPVDSAI---DTISPLNQKFSQYLHENASYVRPLEEGMLHLFES---ITEDTVT 285
            EQ  +    D  I     I  +N+K  + L    + +  L   +  + ++   + E+   
Sbjct: 650  EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 709

Query: 286  VLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSL--CTSALRARNLELSQDMK 343
            + + T K+K   + L + +   +     Q+ S+ +E E S+     AL+ +  +L   +K
Sbjct: 710  LKDQTDKMK---QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766

Query: 344  KMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKA 403
            +     ++ Q ++  L       +G L+           A L  F       S  + Q  
Sbjct: 767  ERDKHLKEHQAHVENLEADIKRSEGELQ--------QASAKLDVFQSYQ---SATHEQTK 815

Query: 404  AIEHELPTATQKLIT--TNDCILSSVVALTNGAGKIASFF------------------SN 443
            A E +L    QKL+   T   +L+  VA      K                       ++
Sbjct: 816  AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875

Query: 444  NLDYFIASLS--YGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALAN 501
             ++  + SL+  Y  K   G       + +L  K+     M+  +K  +E +  + +   
Sbjct: 876  EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935

Query: 502  RRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWM---LEAQLAKIKLEKENQRIADKL 558
              I + + E       Q ++ +EK+ +  +E +  +   L  Q AK+K E EN  +    
Sbjct: 936  DSIHILNEEYETKFKNQ-EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994

Query: 559  KNTG-SAQLVGLAQENAA-VSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVES 616
            K    +A+++ +AQ N+A +S+   + E   K  +E         +LT     E+ DV S
Sbjct: 995  KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE---------SLTEVHRRELNDVIS 1045

Query: 617  REDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQ 676
              +   N     + E+  ++QL + +      E   L +++ L    KE + +E+    +
Sbjct: 1046 IWEKKLNQQAEELQEI-HEIQLQEKEQ-----EVAELKQKILLFGCEKEEMNKEITWLKE 1099

Query: 677  NISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKN 731
               + QD   TT    ++QL   S H+ S+ +  +K +  ++ L++    + K+N
Sbjct: 1100 EGVK-QD---TTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 147/729 (20%), Positives = 287/729 (39%), Gaps = 107/729 (14%)

Query: 6    LRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKNKKSGESSSQLSQEQKSVFDE 64
            L++ +QE+  L  + L      E +  E+  L E   K++    E   QL  +QKS    
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--KQKSAHVN 1123

Query: 65   DLQKKIEENERLHIQFFEADEQHKHVEAE-LRSRLATLETEAAQHQAVVDGLTRKYMETI 123
             L +  E   + H++  E D      E   L+ +L  L+  A + +  V  LT K   T 
Sbjct: 1124 SLAQD-ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTD 1182

Query: 124  EKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFN 183
            E+ Q+ K+  E  +++LE ++ E +  +EE  +QL    +     LE      NE +  +
Sbjct: 1183 EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK---TNELINIS 1239

Query: 184  DTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSA 243
             +K +    L+   H +    K+++               L+   T +E   Q+  +   
Sbjct: 1240 SSKTNA--ILSRISHCQHRTTKVKE-------------ALLIKTCTVSELEAQLRQLTEE 1284

Query: 244  IDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 303
             +T++   Q+ +  L E  + ++ ++  +  L   +TE      E   + +  SE   S 
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESL---VTEKEALQKEGGNQQQAASEK-ESC 1340

Query: 304  ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPS 363
            I  L+K L   + ++      +L    L+ + +E+S   K++T +  +LQ  I+L     
Sbjct: 1341 ITQLKKELSENINAV------TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL----- 1389

Query: 364  TEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCI 423
            +E +                        +  + K Y ++     EL    Q L    D +
Sbjct: 1390 SEKEA----------------------AISSLRKQYDEEKC---ELLDQVQDLSFKVDTL 1424

Query: 424  LSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYK---KKAAA 480
                ++        ++ FS           +  KA S F    +    LQ +   K   A
Sbjct: 1425 SKEKISALEQVDDWSNKFS----------EWKKKAQSRFTQHQNTVKELQIQLELKSKEA 1474

Query: 481  YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540
            Y K  +  LL+    E    N+R         + L  +++    K+ K E   E   L++
Sbjct: 1475 YEKDEQINLLKE---ELDQQNKRF--------DCLKGEMEDDKSKMEKKESNLE-TELKS 1522

Query: 541  QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
            Q A+I           +L++  + + + +   N  + N   Q +   K +++ +Q    +
Sbjct: 1523 QTARIM----------ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572

Query: 601  GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYA---ECRALSKRL 657
            G      D+ V + E +   ++N   +   EL ++ +  +  ++   +   E +AL  R 
Sbjct: 1573 G---EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR- 1628

Query: 658  ALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD-HLCSMNETLSKQREE 716
             L  +S   L E  + A Q I+ ++ +L +     E+Q    ++ HL  +N  L ++  E
Sbjct: 1629 -LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687

Query: 717  IDTLKMSSK 725
            +  L+   K
Sbjct: 1688 VHILEEKLK 1696



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 130/686 (18%), Positives = 275/686 (40%), Gaps = 97/686 (14%)

Query: 60   SVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKY 119
            S  +  L++  EE   L+I F +A  Q +  E +++S  A +E+   + +A+      + 
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ 1331

Query: 120  METIEK---LQNDKAKLE--VKSQTLEKEA-KECRLRTEECQLQLKTLHEDLSGRLEESL 173
                EK   +   K +L   + + TL KE  KE ++       QL     DL+ +L+ S+
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT----DLNVQLQNSI 1387

Query: 174  SIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ 233
            S+  ++   +  +  QY+     L ++                VQDL        T +++
Sbjct: 1388 SLSEKEAAISSLR-KQYDEEKCELLDQ----------------VQDLS---FKVDTLSKE 1427

Query: 234  RIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKL 293
            +I      SA++ +   + KFS++  +  S                T+   TV E  ++L
Sbjct: 1428 KI------SALEQVDDWSNKFSEWKKKAQS--------------RFTQHQNTVKELQIQL 1467

Query: 294  KTFSEHL---TSYICFLRKILPYQLKS---LEEECESSLCTSALRARNLELSQDMKKMTA 347
            +  S+        I  L++ L  Q K    L+ E E        +  NLE   ++K  TA
Sbjct: 1468 ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET--ELKSQTA 1525

Query: 348  VFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI-E 406
               +L+ +I    +   E + L     + VL N        H  +    +H+ +     +
Sbjct: 1526 RIMELEDHITQKTI---EIESL-----NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKD 1577

Query: 407  HELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPL 466
            + +  A +K++T  + + S    L     ++      +++  + S     KA    +   
Sbjct: 1578 NRVKEAEEKILTLENQVYSMKAELETKKKEL-----EHVNLSVKSKEEELKALEDRLESE 1632

Query: 467  SAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKI 526
            SA  + + K+KA   + +++K LL  +  +E            + ++G    + +   K+
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE-----------QYKKGTESHLSELNTKL 1681

Query: 527  SKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEAT 586
               E+E+E  +LE +L  ++  +    I  +     +  +    ++  A S    Q    
Sbjct: 1682 Q--EREREVHILEEKLKSVESSQSETLIVPR----SAKNVAAYTEQEEADSQGCVQKTYE 1735

Query: 587  AKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT-SQLQLADSKSV- 644
             K  +     T     L R    +   V S  ++ +  Y  R+++L  ++ +  + +S+ 
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEM-RCQYQERLIKLEHAEAKQHEDQSMI 1794

Query: 645  -HFYAECRALSKRLAL--AEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD 701
             H   E    +K+ +L  A+  ++   +    A QN+  + D++  T +  E    ++  
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854

Query: 702  HLCSMNETLSKQRE--EIDTLKMSSK 725
             +  ++  L +Q+E   ++  +++SK
Sbjct: 1855 KIKELDSCLVRQKEVHRVEMEELTSK 1880



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 141/783 (18%), Positives = 304/783 (38%), Gaps = 101/783 (12%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDEL--ALSEPRGKKNKKSGESSSQLSQ--E 57
            ++  L++ ++ + S   +   L    E LQ++L   L E    K+    E +  ++Q  +
Sbjct: 291  QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350

Query: 58   QKSVFDEDLQKK---IEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 114
             K++ ++  Q K   I E +R   Q  E  E  +   A+LRSR+  + T+  + +   + 
Sbjct: 351  AKNLIEQLEQDKGMVIAETKR---QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407

Query: 115  LTRKYMETIEKLQND-----------KAKLEVKSQTLEKEAKECRL-------------- 149
              R   E +EK  +            KA+++ + +T+EK ++E R+              
Sbjct: 408  SERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV 467

Query: 150  -----RTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQL 204
                  +EE   +L+ LHE    R E+ L+   +K+   + ++ +   + +      +  
Sbjct: 468  DVMKKSSEEQIAKLQKLHEKELARKEQELT---KKLQTREREFQEQMKVALEKSQSEYLK 524

Query: 205  KMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAI--DTISPLNQKFSQYLHENA 262
              ++   Q    +++L        T +E +++    ++      I  L     + L EN 
Sbjct: 525  ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584

Query: 263  SYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL--------TSYICFLRKILPYQ 314
            +  + L    +HL     +    +     K KT  E L        T  +  L++    +
Sbjct: 585  NQSKDL---AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641

Query: 315  LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 374
            ++ L E+CE    T  L+ + +     +++M       +  +  L +  TE + L     
Sbjct: 642  MEKLREKCEQEKET-LLKDKEIIFQAHIEEMN------EKTLEKLDVKQTELESL----- 689

Query: 375  SSVLTNVGAALHGFHD---VMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALT 431
            SS L+ V  A H   +   V+KD +    Q+  +E ++           D I+       
Sbjct: 690  SSELSEVLKARHKLEEELSVLKDQTDKMKQE--LEAKMDEQKNHHQQQVDSIIKEHEVSI 747

Query: 432  NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC------MLQYKKKAAAYMKSL 485
                K      N L+  +       K     +  L A+       + Q   K   +    
Sbjct: 748  QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807

Query: 486  RKPLLESVPYEEALAN-RRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAK 544
                 ++  YEE LA  ++ LL     R  L +QV +   +   +  E +   ++ Q   
Sbjct: 808  SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867

Query: 545  IKLEKENQRIADKLKN---------------TGSAQLVGLAQENAAVSNTAGQDEATAKA 589
             +LEK+N  +  K+K+                   + + + +EN  +    GQ +     
Sbjct: 868  QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEIL 927

Query: 590  VLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAE 649
              +       I  L    +++  + E + + +K    A+ ++ T + +L D ++     +
Sbjct: 928  TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ--KAKEMQETLKKKLLDQEA---KLK 982

Query: 650  CRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD-HLCSMNE 708
                +  L L++K K+   + +++A  N + + D ++  + + ++Q+  +++ H   +N+
Sbjct: 983  KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1042

Query: 709  TLS 711
             +S
Sbjct: 1043 VIS 1045



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 42/184 (22%), Positives = 77/184 (41%), Gaps = 23/184 (12%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            KD+ +  L++E+D       Q  KR + L+ E+   + + K  KK     ++L  +   +
Sbjct: 1477 KDEQINLLKEELD-------QQNKRFDCLKGEM--EDDKSKMEKKESNLETELKSQTARI 1527

Query: 62   F---DEDLQKKIEE---NERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 115
                D   QK IE    NE L     + D +HK +  +L+      E +        D  
Sbjct: 1528 MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK--------DNR 1579

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             ++  E I  L+N    ++ + +T +KE +   L  +  + +LK L + L       L+ 
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639

Query: 176  INEK 179
            +  K
Sbjct: 1640 LKRK 1643



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 59/305 (19%), Positives = 126/305 (41%), Gaps = 37/305 (12%)

Query: 443 NNLDYFIASLSYGPKAAS--------GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 494
           N LD   ++ S+ P +          G    L+ E ++Q  ++    + S R    E V 
Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162

Query: 495 YEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQEKEHWMLE-----------AQ 541
             + L   +  L    ++S++   +++ +  E++   +Q K+H   E             
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYIS 222

Query: 542 LAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIG 601
           + + ++    QR+ +   N    + +   +  A V       E+  + V+E   S   + 
Sbjct: 223 VLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLE 282

Query: 602 TLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAE 661
           TL +    +   ++  ++ I++H   +   LTS+ +    +          L +RL   E
Sbjct: 283 TLQQRVKRQENLLKRCKETIQSH-KEQCTLLTSEKEALQEQ----------LDERLQELE 331

Query: 662 KSKEA-LTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
           K K+  + E+ KL    I++L+D     ++  +D+  ++++    M+ETL  + EEI  L
Sbjct: 332 KIKDLHMAEKTKL----ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387

Query: 721 KMSSK 725
           +   K
Sbjct: 388 RSRIK 392



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 26/113 (23%), Positives = 50/113 (44%), Gaps = 11/113 (9%)

Query: 22   QLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 81
            QL K++    D+L       K+  K  E      +E+ +    DLQ ++EE ++ + Q  
Sbjct: 2040 QLLKKIAEKDDDL-------KRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKL 2092

Query: 82   EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 134
            E +E   +    +      L+T+ AQ   ++     K  E  E++ N + +L+
Sbjct: 2093 EQEENPGNDNVTIME----LQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 166/846 (19%), Positives = 303/846 (35%), Gaps = 132/846 (15%)

Query: 1    MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELA-LSEPRGKKN---KKSGESSSQLSQ 56
            + DQ + +LQ ++  L    +QLAK+ E LQ  LA + E   +KN   KK  E  SQ+S+
Sbjct: 1060 LSDQ-IAELQAQIAEL---KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115

Query: 57   EQKSVFDEDLQK-KIEENERLHIQFFEA---------------DEQHKHVEAELRSRLAT 100
             Q+ +  E   + K E+ +R   +  EA                E     E E+     T
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175

Query: 101  LETEAAQHQAVVDGLTRKYMETIEKLQND-------KAKLEVKSQTLEKEAKECRLRTEE 153
            LE EA  H+A +  + +K+ + +E+L          KA LE   QTLE E  E      E
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL---ANE 1232

Query: 154  CQLQLKTLHEDLSGRLEESLSIINEKVPFNDTK------YSQYNALNVPLHNRRHQLKMR 207
             ++ L+   +    R +    +   +V FN+ +        +   L V L N    L   
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292

Query: 208  DIAGQALAFVQDLVTALL--NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYV 265
            D     L      + + L        E+  Q   + + +  +      F + L E     
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK 1352

Query: 266  RPLEEGMLHLFESIT------EDTVTVLETTVKLKT--------FSEHLTSYICFLRKIL 311
              LE+ +  L   +       ED+V  LET  ++K          S+     +    K+ 
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

Query: 312  PYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLR 371
              + +  +E  +  +     R     L +  KK   +  + +T  A  A      +   R
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 372  TNYSSVL------------------------TNVGAALHGFHDVMKDISKHYSQKAAIE- 406
               +  L                        T +   +    DV K + +    K A+E 
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532

Query: 407  --HELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFIS 464
               E+ T  ++L         + + L      + + F  +L           K     + 
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592

Query: 465  PLSAECMLQYKKK--AAAYMKSLRKPLLESVPY--------EEALANRRILLSSTESREG 514
             + AE   + K++  A A  K L   L +   +        +EA+   R L +  +    
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652

Query: 515  LAQQVQQSLEKI--SKLEQEKEHWMLEAQL------------AKIKLEKENQRIADKLKN 560
                 + S E+I     E EK+   +EA++            AK + ++E   +AD++ N
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712

Query: 561  TGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDL 620
            +     + L ++    +  A  +E     + E   +T LI    + ++ ++  + +  +L
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEE----ELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768

Query: 621  IKNHYM----------ARIVELTSQLQ-LADSKSVHFYAECRALSKRLALAEKSKEALTE 669
             ++H             +  EL  +LQ +  +    + A   AL  ++A  E+  +  T+
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828

Query: 670  EMKLASQNISRLQ----------DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDT 719
            E + A + + R +          D+       Y+DQ    S  L  +   L +  EE   
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888

Query: 720  LKMSSK 725
               S +
Sbjct: 1889 ANASRR 1894



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 143/724 (19%), Positives = 281/724 (38%), Gaps = 106/724 (14%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            +  L+KL++E   L  +N +LAK  +LL+D +A       + ++  +S ++L  + +++ 
Sbjct: 970  EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029

Query: 63   DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
              DL++++   E+   Q  E ++  + +E +       L  + A+ QA +  L  +  + 
Sbjct: 1030 -TDLEERLRREEK---QRQELEKTRRKLEGD----STDLSDQIAELQAQIAELKMQLAKK 1081

Query: 123  IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPF 182
             E+LQ   A++E ++       K+ R    E + Q+  L EDL            +K   
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIR----ELESQISELQEDLESERASRNKAEKQKRDL 1137

Query: 183  NDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDS 242
             +   +    L   L +   Q ++R    Q +  ++  +      H   E +IQ      
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH---EAQIQ------ 1188

Query: 243  AIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTS 302
                   + QK SQ + E A  +               E T  V     K K   E+   
Sbjct: 1189 ------EMRQKHSQAVEELAEQL---------------EQTKRVKANLEKAKQTLENERG 1227

Query: 303  YICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALP 362
             +    K+L      L+ + +S      + A+  EL     +   V  +L   +  L + 
Sbjct: 1228 ELANEVKVL------LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 363  STEPDGLL--RTNYSSVLTNVGAALHG-FHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
                 GLL    + SS LT   +AL     D  + + +   QK ++  +L     +  + 
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341

Query: 420  NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA 479
             + +     A  N   +IA+  +      +A +    + + G +     E   + K+K  
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQ-----VADMKKKMEDSVGCL-----ETAEEVKRKLQ 1391

Query: 480  AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLE 539
              ++ L      S  +EE +A       + +  E    ++QQ L+    L  + +H    
Sbjct: 1392 KDLEGL------SQRHEEKVA-------AYDKLEKTKTRLQQELD---DLLVDLDHQRQS 1435

Query: 540  AQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDE----ATAKAVLEPIQ 595
            A   + K +K +Q +A+  + T SA+    A+E       A + E    + A+A+ E ++
Sbjct: 1436 ACNLEKKQKKFDQLLAE--EKTISAK---YAEERDRAEAEAREKETKALSLARALEEAME 1490

Query: 596  STSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAEC-RALS 654
              + +  L +   +E+ D+ S +D +                    KSVH   +  RAL 
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDV-------------------GKSVHELEKSKRALE 1531

Query: 655  KRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQR 714
            +++   +   E L +E++       RL+  L   K  +E  L    +      + L +Q 
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591

Query: 715  EEID 718
             E++
Sbjct: 1592 REME 1595



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 74/313 (23%), Positives = 124/313 (39%), Gaps = 53/313 (16%)

Query: 466  LSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEK 525
            L  +  LQ + +  A  + LR  L       E + +   L +  E  E   Q +Q   +K
Sbjct: 883  LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD--LEARVEEEEERCQHLQAEKKK 940

Query: 526  ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLV------GLAQENAAVSNT 579
            + +  QE E  + E + A+ KL+ E      KLK     Q++       LA+E   + + 
Sbjct: 941  MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000

Query: 580  AGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVE--------SREDLIKN-------- 623
                E T     E  +S SL   L    ++ + D+E         R++L K         
Sbjct: 1001 IA--EFTTNLTEEEEKSKSL-AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 624  --------HYMARIVELTSQLQLADSKSVHFYA--ECRALSKRLALAE-KSKEALTEEMK 672
                       A+I EL  QL   + +     A  E  A  K +AL + +  E+   E++
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117

Query: 673  --LASQNISR---------LQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK 721
              L S+  SR         L +EL   K   ED L    D   +  E  SK+ +E++ LK
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTL----DSTAAQQELRSKREQEVNILK 1173

Query: 722  MSSKGNSKKNKSR 734
             + +  +K ++++
Sbjct: 1174 KTLEEEAKTHEAQ 1186



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 130/775 (16%), Positives = 285/775 (36%), Gaps = 105/775 (13%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            ++  R L +E+++L        +  + L    A  E R K+ ++       L +E K+  
Sbjct: 1131 EKQKRDLGEELEALK------TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT-H 1183

Query: 63   DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
            +  +Q+  +++ +   +  E  EQ K V+A L     TLE E  +    V  L +   ++
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243

Query: 123  IEKLQNDKAKLE---VKSQTLEKEAKECRLRTEECQLQLKTL------HEDLSGRLEESL 173
              K +  +A+L+   VK    E+   E   +  + Q++L  +       +  S +L +  
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303

Query: 174  SIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ 233
            S +  ++        + N   + L       K++ +  +  +F + L       H   +Q
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLST-----KLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358

Query: 234  ----RIQIFPVDSAI-DTISPLN--QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV 286
                  Q+  +   + D++  L   ++  + L ++   +    E  +  ++ + +    +
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418

Query: 287  LETTVKLKTFSEHLTSYICFLRKILPY--QLKSLEEECESSLCTSALRARNLELSQDMKK 344
             +    L    +H     C L K      QL + E+   +       RA      ++ K 
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478

Query: 345  MT---AVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQ 401
            ++   A+ E ++    L  L         RT    ++++        H++ K       Q
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQ-----FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 402  KAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASG 461
               ++ +L     +L  T D  L   V L      + + F  +L           K    
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQ----AMKAQFERDLQGRDEQSEEKKKQLVR 1589

Query: 462  FISPLSAECMLQYKKK--AAAYMKSLRKPLLESVPY--------EEALANRRILLSSTE- 510
             +  + AE   + K++  A A  K L   L +   +        +EA+   R L +  + 
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649

Query: 511  ----------SREGLAQQVQQSLEKISKLEQEK---EHWMLEAQLAKIKLEKENQRIADK 557
                      SRE +  Q +++ +K+  +E E    +  +  A+ AK + ++E   +AD+
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709

Query: 558  LKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESR 617
            + N+     + L ++    +  A  +E       E   +T LI    + ++ ++  + + 
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELE----EEQGNTELINDRLKKANLQIDQINTD 1765

Query: 618  EDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQN 677
             +L ++H                             +++   A +  E   +E+K+    
Sbjct: 1766 LNLERSH-----------------------------AQKNENARQQLERQNKELKV---- 1792

Query: 678  ISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNK 732
              +LQ+   T K  Y+  ++ +   +  + E L  + +E        +   KK K
Sbjct: 1793 --KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 150/758 (19%), Positives = 304/758 (40%), Gaps = 75/758 (9%)

Query: 1   MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
           ++D ++  LQ ++  L   N       +LL+ EL +      K+ K G S + +      
Sbjct: 142 VRDSTMLDLQAQLKELQREN-------DLLRKELDI------KDSKLGSSMNSIKTFWSP 188

Query: 61  VFDEDLQKKIEENERLHI---QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTR 117
              ++   + EE  R+ +   Q   + E+++H++  +++    L T+   +  +      
Sbjct: 189 ELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGN 248

Query: 118 KYME--TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
           +  E  TIE  + +  +L+ +     KE    R   EE +L+++T  + L+ R +ES+  
Sbjct: 249 RGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNAR-DESIKK 307

Query: 176 INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI 235
           + E +    +K     +L       R   +           +       ++      +R 
Sbjct: 308 LLEML---QSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRS 364

Query: 236 QIFPVDS---AIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFES---ITEDTVTVLET 289
           Q+ P  +   A+ T+  +       L  N   +R LE+ +  L  +    TED    ++ 
Sbjct: 365 QLQPEPAKTKALQTVIEMKDTKIASLERN---IRDLEDEIQMLKANGVLNTEDREEEIKQ 421

Query: 290 TVKLKTFSEHLTSYICFLRKILPY---QLKSLEEECESSLCTSALRARNLELSQDMKKMT 346
               K+ S+ + + I  L++ L     +L +L+ + E+    ++   +++E+ ++   +T
Sbjct: 422 IEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKE--SLT 479

Query: 347 AVFEK---LQTYIALLALPSTEPDGLL--RTNYSSVLTNVGAALHGFHDVMKDISKHYSQ 401
           A  ++   LQT +  L L   E +  L  +T     LT     L G    MKD+ +    
Sbjct: 480 AKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLE---- 535

Query: 402 KAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFF--SNNLDYFIASLSYGPKAA 459
               E ++    +K+    + +      LTN   ++ S    S+N D  +A+L       
Sbjct: 536 --VKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEK 593

Query: 460 SGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTES-----REG 514
              I  L  +     +++    ++S RK   E+   +E +   +  L+  ES     +E 
Sbjct: 594 ERIIERLKEQRERDDRERLEE-IESFRK---ENKDLKEKVNALQAELTEKESSLIDLKEH 649

Query: 515 LAQQVQQSLEKISKL-------EQEKEHWM-LEAQLAKIKLEKENQRIADKLKNTGSAQL 566
            +      L++ SKL       EQ+KE    LEAQL K    +++ R+  +  +    Q+
Sbjct: 650 ASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFAD----QI 705

Query: 567 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
             L +E +   +  G+ +A    +LE ++    +       D ++ ++ES          
Sbjct: 706 KQLDKEASYYRDECGKAQAEVDRLLEILKE---VENEKNDKDKKIAELESLTLRHMKDQN 762

Query: 627 ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
            ++  L    QL   K+     E R   +  ++A+ S+    EE+  A +   +  D   
Sbjct: 763 KKVANLKHNQQLEKKKNAQLLEEVRR--REDSMADNSQHLQIEELMNALEKTRQELDATK 820

Query: 687 TTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSS 724
               S +  L+    HL ++     KQ EEI  +K  +
Sbjct: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEA 858


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 150/761 (19%), Positives = 289/761 (37%), Gaps = 99/761 (13%)

Query: 1    MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
            ++DQ + +LQ ++D L    LQLAK+ E LQ  LA  +        + +   +L Q Q +
Sbjct: 1067 LQDQ-IAELQAQIDEL---KLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIA 1121

Query: 61   VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLAT-------------------- 100
               ED + +     +   Q  +  E+ + ++ EL   L T                    
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181

Query: 101  -LETEAAQHQAVVDGLTRKYMETIEKLQND-------KAKLEVKSQTLEKEAKECRLRTE 152
             LE E   H+A +  + +++   +E+L          KA LE   Q LE + KE     +
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241

Query: 153  ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLK--MRDIA 210
              Q Q+K   E    +L+  +  ++ KV   D    +       L N    +   + +  
Sbjct: 1242 VLQ-QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300

Query: 211  GQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEE 270
             + + F +D  +         E ++Q        DT   L ++  Q L+  +S +R LEE
Sbjct: 1301 KKGIKFAKDAAS--------LESQLQ--------DTQELLQEETRQKLN-LSSRIRQLEE 1343

Query: 271  GMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLE--EECESSLCT 328
                L E   E+     E    L+     L S +   +K +   L ++E  EE +  L  
Sbjct: 1344 EKNSLQEQQEEEE----EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 329  SALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSSVLTNVGAALH 386
             A       LSQ +++    ++KL+     L     E D L     +   V +N+     
Sbjct: 1400 DA-----EALSQRLEEKALAYDKLEKTKNRL---QQELDDLTVDLDHQRQVASNLEKKQK 1451

Query: 387  GFHDVM---KDISKHYS-QKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFS 442
             F  ++   K IS  Y+ ++   E E      K ++    +  ++ A      +     +
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA 1511

Query: 443  NNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANR 502
            +  D   +    G                L+  K+A        +  LE +  +E  A  
Sbjct: 1512 DMEDLMSSKDDVGKNVHE-----------LEKSKRALEQQVEEMRTQLEELE-DELQATE 1559

Query: 503  RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTG 562
               L    + + +  Q ++ L+   +  +EK+  +++ Q+ +++ E E++R    L    
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVAS 1618

Query: 563  SAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIK 622
              ++         + +   Q EA  KA  E I+    +    +    E+ +  +  D I 
Sbjct: 1619 KKKM------EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI- 1671

Query: 623  NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 682
                A+  E   +L+  +++ +    E  +  +    AE+ ++ L +E+  ++   S L 
Sbjct: 1672 ---FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALL 1728

Query: 683  DE---LTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
            DE   L       E++L     ++  +N+   K   ++DTL
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL 1769



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 139/745 (18%), Positives = 288/745 (38%), Gaps = 99/745 (13%)

Query: 21   LQLAKRVELLQ--DELALSEPRGKKNKKSGESSS-----QLSQEQKSVFDEDLQKKIEEN 73
            LQ+ ++ E LQ  DE  L + + K+ K  GE        Q   E+K++  E LQ + E  
Sbjct: 845  LQVTRQEEELQAKDE-ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE-- 901

Query: 74   ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 133
                  F EA+E        +R+RLA  + E  +    ++    +  E  + LQN+K K+
Sbjct: 902  -----LFAEAEE--------MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948

Query: 134  EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 193
            +   Q LE++  E     ++ QL+  T    +  ++EE + ++ ++   N     +   +
Sbjct: 949  QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-KMEEEILLLEDQ---NSKFIKEKKLM 1004

Query: 194  NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQK 253
               +     QL   +   + LA +++            +Q + I  ++  +       Q+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRN------------KQEVMISDLEERLKKEEKTRQE 1052

Query: 254  FSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK-------TFSEHLTSYICF 306
              +   +       L++ +  L   I E  + + +   +L+         + H  + +  
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112

Query: 307  LRKILPYQLKSLEEECESSLCT-SALRARNLELSQDMKKM-TAVFEKLQTYIALLALPST 364
            +R+ L  Q+  L+E+ ES   + +    +  +LS++++ + T + + L T  A   L + 
Sbjct: 1113 VRE-LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK 1171

Query: 365  EPDGL--LRTNYSSVLTNVGAALHGFHD----VMKDISKHYSQKAAIEHELPTATQKLIT 418
                +  L+        N  A +          ++++S+   Q    +  L    Q L T
Sbjct: 1172 REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231

Query: 419  TNDCILSSVVALTNGAGKIASFFSNNLDYFI----ASLSYGPKAASGFISPLS------- 467
             N  +   V  L     + +      LD  +    A +S G +         S       
Sbjct: 1232 DNKELACEVKVLQQVKAE-SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290

Query: 468  --AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEK 525
              +  + + +KK   + K      LES    +    + +L   T  +  L+ +++Q  E+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAAS--LES----QLQDTQELLQEETRQKLNLSSRIRQLEEE 1344

Query: 526  ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEA 585
             + L++++E    E + A+  LEK+   +  +L +T              V +  G  E+
Sbjct: 1345 KNSLQEQQE----EEEEARKNLEKQVLALQSQLADT-----------KKKVDDDLGTIES 1389

Query: 586  TAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADS---- 641
              +A  + ++    +             +E  ++ ++       V+L  Q Q+A +    
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449

Query: 642  --KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE---DQL 696
              K     AE +++S R A      EA   E +  + +++R  +E    K  +E    QL
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509

Query: 697  SMMSDHLCSMNETLSKQREEIDTLK 721
                + L S  + + K   E++  K
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSK 1534



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 145/738 (19%), Positives = 280/738 (37%), Gaps = 94/738 (12%)

Query: 1    MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKK-----SGESSSQLS 55
            + D   R  ++E  +   +N +   +  +   E  L E  G + K      + E+  +  
Sbjct: 924  LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKM 983

Query: 56   QEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 115
            +E+  + ++   K I+E + +  +  E   Q    E E    LA +  +     + ++  
Sbjct: 984  EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE-EEEKAKNLAKIRNKQEVMISDLEER 1042

Query: 116  TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 175
             +K  +T ++L+  K KL+ ++  L+ +  E + + +E +LQL    E+L G L      
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG--- 1099

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRI 235
                   +D    + NAL V          +R++  Q     +D  +   + +   +Q+ 
Sbjct: 1100 -------DDETLHKNNALKV----------VRELQAQIAELQEDFESEKASRNKAEKQKR 1142

Query: 236  QI--------FPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 287
             +          ++  +DT +   +  ++   E A   + LEE   +  E+  +D     
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN-HEAQIQDMRQRH 1201

Query: 288  ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLC-TSALRARNLELSQDMKKMT 346
             T   L+  SE L     F +  L    + LE + +   C    L+    E     KK+ 
Sbjct: 1202 ATA--LEELSEQLEQAKRF-KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 347  AVFEKLQTYIA---LLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKA 403
            A  ++L   ++    L +   E    L+    +V T +  A        KD +   SQ  
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318

Query: 404  AIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFI 463
              +  L   T++ +  +  I                     L+    SL    +      
Sbjct: 1319 DTQELLQEETRQKLNLSSRI-------------------RQLEEEKNSLQEQQEEEEEAR 1359

Query: 464  SPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSL 523
              L  + +L  + + A   K +   L      EEA   ++ LL   E+   L+Q++++  
Sbjct: 1360 KNLEKQ-VLALQSQLADTKKKVDDDLGTIESLEEA---KKKLLKDAEA---LSQRLEEKA 1412

Query: 524  EKISKLEQEKEHWMLEAQLAKIKLEKENQR-IADKLKNTGSAQLVGLAQENAAVSNTAGQ 582
                KLE+ K    L+ +L  + ++ ++QR +A  L+         LA+E +  +  A +
Sbjct: 1413 LAYDKLEKTKNR--LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470

Query: 583  -DEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADS 641
             D A A+A  +  ++ SL   L          +E++E+  + +   R         L  S
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEA-------LEAKEEFERQNKQLR----ADMEDLMSS 1519

Query: 642  KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTT---KRSYEDQLSM 698
            K          + K +   EKSK AL ++++     +  L+DEL  T   K   E  +  
Sbjct: 1520 KD--------DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 699  MSDHLCSMNETLSKQREE 716
            M        +T  +Q EE
Sbjct: 1572 MKAQFERDLQTRDEQNEE 1589



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 54/268 (20%), Positives = 116/268 (43%), Gaps = 26/268 (9%)

Query: 482  MKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQE---KEHWML 538
            +K LRK   +   Y+  L   R       SR+ +  Q ++S +K+  LE E    +  + 
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARA------SRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697

Query: 539  EAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN------AAVSNTAGQDEATAKAVLE 592
             ++ A+   E+E   +AD++ N+ S +   L ++       A +     ++++  + + +
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 593  PIQSTSL-IGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQ-LADSKSVHFYAEC 650
              + T+L + TL     +E      + D  +     +  EL ++LQ L  +    F A  
Sbjct: 1758 RFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816

Query: 651  RALSKRLALAEKSKEALTEEMKLASQNISRLQDEL------TTTKRSYEDQLSMMSDHLC 704
             AL  ++   E+  E   +E   A++ + R + +L         +R + DQ     +   
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876

Query: 705  SMNETLSKQREEIDTLKMSSKGNSKKNK 732
            +  + L +Q EE +  + +++ N+ + K
Sbjct: 1877 ARMKQLKRQLEEAE--EEATRANASRRK 1902



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 20/68 (29%), Positives = 32/68 (47%)

Query: 5    SLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE 64
            S RKLQ+E+D  T  N  L++ V  L++ L    P    + +SG     L      + D+
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDD 1958

Query: 65   DLQKKIEE 72
            D + K  +
Sbjct: 1959 DTESKTSD 1966



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 44/217 (20%), Positives = 85/217 (39%), Gaps = 12/217 (5%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
            ++ L + Q  M+ L  R  +   +V+ L  ELA      +K+  + +   + ++E K+  
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801

Query: 63   DEDLQKKIEENERLHIQFFEAD--EQHKHVEAELRSRLAT------LETEAAQHQAVVDG 114
             E L+  ++   +  I   EA   +  + +E E + R A        E +  +    V+ 
Sbjct: 1802 QE-LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860

Query: 115  LTR---KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEE 171
              R   +Y E +EK      +L+ + +  E+EA        + Q +L    E   G   E
Sbjct: 1861 ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSRE 1920

Query: 172  SLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRD 208
              ++ N         +S   +    LH     L++ D
Sbjct: 1921 VSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSD 1957


>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
          Length = 1946

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 167/784 (21%), Positives = 310/784 (39%), Gaps = 128/784 (16%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPR----GKKNKKSGESSSQLSQE 57
            KD+S   LQ E+D L  R  Q+ +     +    L E R      K  K  + ++ L+ +
Sbjct: 1231 KDKS--DLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQ 1288

Query: 58   QKSVFDE--DLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 115
            +  ++ E  +  +++EE E L  Q             +LR +L   E E     A+   L
Sbjct: 1289 KTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL---EKETKSQSALAHAL 1345

Query: 116  TRKYM------ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQ----LKTLHEDL 165
             +         E  E+ Q  KA+L      +  E  + R++ E   +Q    L+   ++L
Sbjct: 1346 QKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL 1405

Query: 166  SGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALL 225
            + RL+E+   +              NA N  L   RHQL++    G AL+ +  + +A  
Sbjct: 1406 AIRLQEAAEAMGVA-----------NARNASLERARHQLQLE--LGDALSDLGKVRSAAA 1452

Query: 226  NFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT 285
                                    L+QK  Q     A + +  EE    L ++  ++   
Sbjct: 1453 R-----------------------LDQKQLQSGKALADWKQKHEESQA-LLDASQKEVQA 1488

Query: 286  VLETTVKLK-TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKK 344
            +    +KLK T+ E +       ++ L  + K+L+EE  +   T+ +R     L++ M+K
Sbjct: 1489 LSTELLKLKNTYEESIVG-----QETLRRENKNLQEEISN--LTNQVREGTKNLTE-MEK 1540

Query: 345  MTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAA 404
            +  + E+ +T + +      E +G L  N S +L      L    ++ + +S+   +   
Sbjct: 1541 VKKLIEEEKTEVQVTL---EETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIEN 1597

Query: 405  IEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFIS 464
               +       L ++ D    S + +T    ++      +L+     LS   +  S    
Sbjct: 1598 FRRKQQCTIDSLQSSLDSEAKSRIEVT----RLKKKMEEDLNEMELQLSCANRQVSEATK 1653

Query: 465  PLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRR--ILLSSTESREGLAQQVQ-- 520
             L     LQ + K           L   +  + A+A RR  +L S  E    L +Q +  
Sbjct: 1654 SLG---QLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERG 1710

Query: 521  ---------QSLEKI--------SKLEQEKEHWMLEAQLAKIKLEKEN-----QRIADKL 558
                     ++ E+I        S L Q+K+   LEA +A+++ E E      Q   +K 
Sbjct: 1711 RRLSEEELLEATERINLFYTQNTSLLSQKKK---LEADVARMQKEAEEVVQECQNAEEKA 1767

Query: 559  KNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRE 618
            K   + +   L++E     +T    E T + + + I  T L   L       +  + SR+
Sbjct: 1768 KKA-AIEAANLSEELKKKQDTIAHLERTRENMEQTI--TDLQKRLAEAEQMAL--MGSRK 1822

Query: 619  DLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI 678
             + K    +R+ EL  +L+    +S    AE +  ++RL   E+  + LT + +   +N+
Sbjct: 1823 QIQKLE--SRVRELEGELEGEIRRS----AEAQRGARRL---ERCIKELTYQAEEDKKNL 1873

Query: 679  SRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK-----MSSKGNSKK 730
            SR+Q   D+L    ++Y+ Q+ +             KQ+ E++ +K       S+ N  K
Sbjct: 1874 SRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLK 1933

Query: 731  NKSR 734
             K+R
Sbjct: 1934 IKAR 1937



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 31/188 (16%)

Query: 565  QLVGLAQENAAVSNTAGQ-----DEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRED 619
            ++ GL +E A +     +     +E  AK V    +   LI  L    ++     E  E 
Sbjct: 860  EVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEW 919

Query: 620  LIKNHYM--ARIVELTSQLQLADSKSVHFYA-------ECRALSKR-------LALAEKS 663
            LIK+     AR+ EL+ +++  +  +    A       EC  L K        L  +EK 
Sbjct: 920  LIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKE 979

Query: 664  KEA-------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCSMNETLSKQ 713
            K         LTEE++  +++IS+L       + +++   D L M  + L S+++   K 
Sbjct: 980  KRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKL 1039

Query: 714  REEIDTLK 721
             +++D L+
Sbjct: 1040 EQQVDELE 1047



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 39/178 (21%), Positives = 80/178 (44%), Gaps = 25/178 (14%)

Query: 6    LRKLQQEMDS-LTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE 64
            ++ L++++++  T R     +R +L QD   L+E   +  +  G S +QL         E
Sbjct: 1127 IKDLKEKLEAERTTRAKMERERADLTQDLADLNE---RLEEVGGSSLAQL---------E 1174

Query: 65   DLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIE 124
              +K+  + ++LH    EA    +   A L+ R        A   A ++G      +  +
Sbjct: 1175 ITKKQETKFQKLHRDMEEATLHFETTSASLKKR-------HADSLAELEGQVENLQQVKQ 1227

Query: 125  KLQNDKAKLEVKSQ---TLEKEAKECRLRTEE-CQLQLKTLHEDLSGRLEESLSIINE 178
            KL+ DK+ L+++     T  ++    +   E+ C L  + LHE  + +L++   + N+
Sbjct: 1228 KLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHE-ATAKLDKVTQLAND 1284


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 161/759 (21%), Positives = 294/759 (38%), Gaps = 121/759 (15%)

Query: 38  EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSR 97
           EP G       E +  L    K+   ++L+K+  E  +  IQ     +  K   AEL+ R
Sbjct: 231 EPNGSGRMDGREPAQLLLLLAKT---QELEKEAHERSQELIQLKSQGDLEK---AELQDR 284

Query: 98  ---LATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEEC 154
              L+ L T++ +     + + +   ET+E L+ +  +L     +L + A+E +L  ++ 
Sbjct: 285 VTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQV 344

Query: 155 QLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQAL 214
              +  +  +    + +     N  +  + + +SQ++  +               A +AL
Sbjct: 345 IKDITQVMVEEGDNIAQGSGHENS-LELDSSIFSQFDYQD---------------ADKAL 388

Query: 215 AFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLH 274
             V+ ++T         + R Q+     A++    L Q+  Q+  E  +  + L++    
Sbjct: 389 TLVRSVLTR--RRQAVQDLRQQLAGCQEAVNL---LQQQHDQWEEEGKALRQRLQK---- 439

Query: 275 LFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKI---LPYQLKSLEEEC--------E 323
               +T +  T+   TV L+   + L+     L+K    L  QL+ LE+E         E
Sbjct: 440 ----LTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE 495

Query: 324 SSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL----------------ALPSTEPD 367
             L   + + +  E  +++       E+LQ  +  L                AL S+  +
Sbjct: 496 LQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE 555

Query: 368 G-LLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSS 426
           G LLR       T V AAL      + ++S   +       +L  A  KL   N+ +   
Sbjct: 556 GELLRQEQ----TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALD 611

Query: 427 VVALTNGAGKI-------------ASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ 473
            V L     ++             A    N L   +A      +A     + L A+  LQ
Sbjct: 612 KVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ--LQ 669

Query: 474 YKKKAAAYMKS-LRKPLLESVPYEEALA-NRRILLSSTESREGLAQQVQQSLEKISKLEQ 531
             ++A A +++ LR    E    ++ L+ +R    ++T   E L Q+ ++  E +++  Q
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729

Query: 532 EKEHWMLEAQLAKIKL---EKENQRIADKLKNTGSAQ------LVGLAQENAAVSNTAGQ 582
           EKE  + E    +++L   E++ Q +A++L+   SA+      L    Q+N+ +  T GQ
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ 789

Query: 583 DEATAKAVL---EPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVE---LTSQL 636
            E   + V    E IQ    +  L    D+E    E   D           E      Q 
Sbjct: 790 LEVQIQTVTQAKEVIQGE--VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847

Query: 637 QLADSKSVHFYAEC---------RALSKRLALAEKSKEALTEEMKLASQNISRLQDELTT 687
           + A  K V+   E          + L+K L   E+ K  L  EM+L  Q     Q E+  
Sbjct: 848 KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL--EMRLKEQ-----QTEMEA 900

Query: 688 TKRSYEDQLSMMSDHLCSMNETLSKQREE-IDTLKMSSK 725
            +   E++ +     LC M     K+R   ++TL  + K
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 149/771 (19%), Positives = 296/771 (38%), Gaps = 113/771 (14%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGK---KNKKSGESSSQLSQEQK 59
            +Q L +L++E  S+  R     +    LQ +LA +E R +   +     E+  Q ++E  
Sbjct: 616  NQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675

Query: 60   SVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKY 119
            +    DL+   EE E +  +  E+    +H +    ++L  L  EA + + V   L R  
Sbjct: 676  AELQADLRDIQEEKEEIQKKLSES----RHQQEAATTQLEQLHQEAKRQEEV---LARAV 728

Query: 120  METIEKLQNDKAKLEVKSQTLEKEAKECRLRTE--------------ECQLQLKTLHEDL 165
             E  E L  +KA LEV+ Q +E++ ++   + +              E Q Q  ++ E  
Sbjct: 729  QEK-EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ-QQNSVIEVT 786

Query: 166  SGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKM-RDIAGQALAFV-QDLVTA 223
             G+LE  +  + +     +    +   L + L   R Q +  RD A + LA   Q+  TA
Sbjct: 787  KGQLEVQIQTVTQA---KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843

Query: 224  LLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDT 283
            L       E+ +               NQ   ++  E + + + L + +    ES+  + 
Sbjct: 844  LEQQKAAHEKEV---------------NQLREKWEKERSWHQQELAKAL----ESLEREK 884

Query: 284  VTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARN-------- 335
               +E  ++LK     +        + +  Q +    + ES+LC   L            
Sbjct: 885  ---MELEMRLKEQQTEM--------EAIQAQREEERTQAESALCQMQLETEKERVSLLET 933

Query: 336  -LELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKD 394
             L+  +++   +   E+L+  + +  L   E  G+L+T        +  A     D +  
Sbjct: 934  LLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAA 993

Query: 395  ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNL----DYFIA 450
            + +  S     + +L    + L        S +VA  +    +       L    +Y   
Sbjct: 994  LQEESSSLLQDKMDLQKQVEDL-------KSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046

Query: 451  SLSYGPKAASGFISPLSAECMLQYKKKAAAY----MKSLRKPLLESVPYEEAL-ANRRIL 505
                  + AS  +S +  E  L   ++A +     + +LR+ + E+   ++ L A   +L
Sbjct: 1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELL 1106

Query: 506  LSSTESREG--LAQQVQ--QSLEKISKLEQE--KEHWMLEAQLAKIKLEKENQRIADKLK 559
                + +E   LAQ+ Q  + LE     EQ+     W  EA+ A+++L   +     +L+
Sbjct: 1107 RQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE--SQLE 1164

Query: 560  NTGSAQLVG-LAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRE 618
               + Q  G  AQ  A +++     +    +V E     S  G    +     PD     
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224

Query: 619  DLIKNHYMARIVELTSQLQLADSKSVH------------FYAECRALSKRLALAEKSKEA 666
             L K   +  +  L+++   +    +H               + + L +RL   E  K  
Sbjct: 1225 SLFKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282

Query: 667  LTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEI 717
            +  E++   + +S+ Q+E    K  +E + + +   L  ++ET++  +  +
Sbjct: 1283 VHTELQDLQRQLSQNQEE----KSKWEGKQNSLESELMELHETMASLQSRL 1329



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 166/803 (20%), Positives = 301/803 (37%), Gaps = 101/803 (12%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKN-KKSGESSSQLSQEQKSVF 62
            Q L +L+Q+M     + L+  +   +LQ +L  ++   K+  ++  +  + L +E  S+ 
Sbjct: 946  QQLERLRQDMK---VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002

Query: 63   DE--DLQKKIEENERLHIQFFEADEQHKHVEAELRSRLA-TLETEAAQHQAVVD--GLTR 117
             +  DLQK++E+   L  Q    D+  + VE E++ +L  T E    Q +   +   LT 
Sbjct: 1003 QDKMDLQKQVED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059

Query: 118  KYMETIEKL----------QNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG 167
              ME  ++L          Q + + L    Q  + E KE   + E  + ++K    D   
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119

Query: 168  R----LEE-SLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAG--------QAL 214
            +    LEE   S I E+         +  A  + L  R  + ++  +A         QA 
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ 1179

Query: 215  AFVQDLVTALLN-FHTYTEQRIQIFPVDSAIDTISPL--NQKFSQYLHENASYVRPLEE- 270
            A +  L +AL     +  E R ++     +  ++  L  +Q  ++ L +    +  L   
Sbjct: 1180 AQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAE 1239

Query: 271  ---GMLH-LFESI--TEDTVTVLETTV-KLK---TFSEHLTSYICFLRKILPYQLKSLEE 320
                 LH L + +  T+ T  VL   V KL+   T +E   S +    + L  QL   +E
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299

Query: 321  ECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTN 380
            E       S    +   L  ++ ++      LQ+ +    L   E  G  R    +   N
Sbjct: 1300 E------KSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE-RELLQAAKEN 1352

Query: 381  VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILS----SVVALTNGAGK 436
            + A +      + +     S    +E +L TA   L   N+ + S    +      G  K
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412

Query: 437  IAS--FFSNNLDYFIASLSYGPKAAS---GFISPLSAECMLQYKKKAAAYMKSL--RKPL 489
            +A       NL     +L+   +      G I  L  +  +Q   KAA  + SL  +K  
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ---KAALELLSLDLKKRN 1469

Query: 490  LESVPYEEALANRRILLSSTESREGLAQQVQQSL----EKISKLEQEKE-------HWML 538
             E    +E +       S  E      Q+ +Q L    E+I +LE+++E       H +L
Sbjct: 1470 QEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLL 1529

Query: 539  EAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN---------AAVSNTAGQDEATAKA 589
            E +     +E +  ++ D  K   + + + L  E            +    GQ E    A
Sbjct: 1530 ELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVA 1589

Query: 590  VLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAE 649
            +              +   S++ D+ES   ++      R  E+ SQ +           +
Sbjct: 1590 LTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE-----------Q 1638

Query: 650  CRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNET 709
               L ++     +  E   +E+ L  + I  L+D+ T   +  E+ L  +   L      
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698

Query: 710  LSKQREEIDTLKMSSKGNSKKNK 732
            L+ QR+ +       KG SK  +
Sbjct: 1699 LTTQRQLMQERAEEGKGPSKAQR 1721



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 137/709 (19%), Positives = 267/709 (37%), Gaps = 77/709 (10%)

Query: 49   ESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQH 108
            E   Q+ + Q+    +DL+K++   E L +   E +E H  +E + +  +  LE +    
Sbjct: 1532 EKKDQMIESQRGQV-QDLKKQLVTLECLAL---ELEENHHKMECQ-QKLIKELEGQRETQ 1586

Query: 109  QAVVDGLTRKYMETIEKLQNDKAK---LEVKSQTL-------EKEAKECRLRTEECQLQL 158
            +  +  LT    E  ++LQ   ++   LE  S  L       ++E K  R + EE Q Q 
Sbjct: 1587 RVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646

Query: 159  KTLHEDLSGRLEESLSIINEKVP-FNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV 217
            + L +DL  R ++ L +  E++    D +  Q   L   L   +  L+ R   G+ L   
Sbjct: 1647 EHLTQDLERR-DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER---GRELTTQ 1702

Query: 218  QDLVT--ALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHL 275
            + L+   A         QR  +  +   +       +   +++HE       LE+ +  L
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762

Query: 276  FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARN 335
               + E ++ + +   ++    + L       R+    + +SL+ + + +    A R + 
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQE----AREQGELKEQSLQSQLDEAQRALAQRDQE 1818

Query: 336  LE-LSQDMKKMTAVFEK-------LQTYIALLALPSTEPDGLLRTNYSSV------LTNV 381
            LE L Q+ ++     E+       LQ  +    +   E  G L+ +          L   
Sbjct: 1819 LEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878

Query: 382  GAALHGFHDVMKDI--SKHYSQKAAI-----------EHELPTAT--------QKLITTN 420
            G  +    +V+ D+       +KA +           EHE+ T          Q ++   
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938

Query: 421  DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPL--SAECMLQYKKKA 478
            D  L ++ A +  +           +    +L     A  G    L   AE     +   
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998

Query: 479  AAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWML 538
            A    SL      S   EEAL  +   +   + R    + VQQ  + +++ ++E  H   
Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQEGEIQDQDLR--YQEDVQQLQQALAQRDEELRHQQE 2056

Query: 539  EAQLAKIKL-EKENQRIADKLKNTGSA----QLVGLAQENAAVSNTAGQDEATAKAVLEP 593
              QL +  L ++  + +  + +N G      ++ GL Q    +  T  Q E     + E 
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116

Query: 594  IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRAL 653
             Q  +L         S + +   + D ++      +  L + L+  +++ + +  + + L
Sbjct: 2117 QQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDL 2176

Query: 654  SKRLALAEKSKEALTEEMKLASQNI-------SRLQDELTTTKRSYEDQ 695
            +  LA  + S  +L E       ++        RLQDEL  T+R+ E +
Sbjct: 2177 ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 145/732 (19%), Positives = 283/732 (38%), Gaps = 94/732 (12%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFD 63
            Q L+KL  E D+L  + + L   V+ L  E  L +            + +  ++Q  V +
Sbjct: 435  QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQ-----------KAREELRQQLEVLE 483

Query: 64   EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETI 123
            ++  +    N  L +Q   A  Q +  + EL   LA  E E  Q   +  GL  K  E++
Sbjct: 484  QEAWRLRRVNVELQLQGDSAQGQKEEQQEELH--LAVRERERLQEMLM--GLEAKQSESL 539

Query: 124  EKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFN 183
             +L   +  LE  S  LE E     LR E+ ++           R E+S++ ++      
Sbjct: 540  SELITLREALE--SSHLEGEL----LRQEQTEVTAAL------ARAEQSIAELSSSENTL 587

Query: 184  DTKYSQYNALNVPLHNRRHQLKMRDIA-GQALAFVQDLVTALLNFHTYTEQRIQIFPVDS 242
             T+ +   A  V L      L +  +   Q L  +++   ++ +     EQ      VD 
Sbjct: 588  KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647

Query: 243  AIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTS 302
            A        +K  + L E  +++    E  L   E    +    L    + K   +   S
Sbjct: 648  AEA------EKRREALWEKNTHL----EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLS 697

Query: 303  YICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALP 362
                 ++    QL+ L +E +       + AR ++  + + +  A  E        + L 
Sbjct: 698  ESRHQQEAATTQLEQLHQEAKRQ---EEVLARAVQEKEALVREKAALE--------VRLQ 746

Query: 363  STEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDC 422
            + E D   R + +  L  + +A       + +  +  S     + +L    Q +    + 
Sbjct: 747  AVERD---RQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803

Query: 423  ILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYM 482
            I   V  L              LD   +       AA+  ++    E     +++ AA+ 
Sbjct: 804  IQGEVRCL-----------KLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHE 852

Query: 483  KSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS------KLEQEKEHW 536
            K + +  L     +E   +++ L  + ES E    +++  L++        + ++E+E  
Sbjct: 853  KEVNQ--LREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910

Query: 537  MLEAQLAKIKLEKENQRIA--DKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPI 594
              E+ L +++LE E +R++  + L  T   +L   +Q+   +     QD    K  L+  
Sbjct: 911  QAESALCQMQLETEKERVSLLETLLQT-QKELADASQQLERLR----QDMKVQK--LKEQ 963

Query: 595  QSTSLIGTLTRTSDSEVPDV--ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRA 652
            ++T ++ T  + +  E+ +   + R+DL      A + E +S L L D   +    E   
Sbjct: 964  ETTGILQTQLQEAQRELKEAARQHRDDL------AALQEESSSL-LQDKMDLQKQVE--D 1014

Query: 653  LSKRLALAEKSKEALTEEMK---LASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNET 709
            L  +L   + S+  + +E++     +Q  +R+Q EL   K S    L      L  + E 
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074

Query: 710  LSKQREEIDTLK 721
             S +++E+  L+
Sbjct: 1075 DSIRQQELSALR 1086



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 49/223 (21%), Positives = 93/223 (41%), Gaps = 33/223 (14%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKK----NKKSGESSSQLSQEQK 59
            +  R+L++E+ ++  R +Q  +  E+L D  A S  + K      ++  E + +   E +
Sbjct: 1866 EQARRLEEEL-AVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922

Query: 60   SVFDEDLQKKIEENER-LHIQFFEADEQH-KHVEAELRSRLATLETEAAQHQAVVDGLTR 117
            ++ D  LQ +    ER   ++   A+ Q  +H E   R+R   L+    +  A + G  +
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQ 1982

Query: 118  KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIIN 177
              +E  E  ++    LE  + TL+     C+                 S +LEE+L I  
Sbjct: 1983 HLLEQAELSRS----LEASTATLQASLDACQAH---------------SRQLEEALRIQE 2023

Query: 178  EKVPFNDTKYSQ-----YNALNVPLHNRRHQLKMRDIAGQALA 215
             ++   D +Y +       AL       RHQ +   +  ++LA
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLA 2066



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 36/171 (21%), Positives = 76/171 (44%), Gaps = 5/171 (2%)

Query: 1    MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
            +KDQ  ++LQ     +   +L L++R    + E+ + + + ++ ++ GE   Q  Q Q  
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQR----EQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806

Query: 61   VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
                 L ++ +E E L  +  +A  Q + V+ +  +    LE +A        G  + + 
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE-QAHMTLKERHGELQDHK 1865

Query: 121  ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEE 171
            E   +L+ + A    + Q LE+   + R  + E +  L  L +  + + +E
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916



 Score = 30.0 bits (66), Expect = 8.0
 Identities = 25/109 (22%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 1    MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
            ++ Q L  L+Q+M        +L+ ++ELL+ E+   E            +  L+QE + 
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE------------ADFLAQEAQL 1124

Query: 61   VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQ 109
            +  E+L+      ++L    +  + +   ++  LRS  + LE  AA+ Q
Sbjct: 1125 L--EELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQ 1171


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 156/783 (19%), Positives = 308/783 (39%), Gaps = 87/783 (11%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            +D     LQ E  + T R  Q     EL +    L   + K  K+  E   ++     ++
Sbjct: 1180 RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI 1239

Query: 62   FDEDLQKKIEENER----LHIQFFEA---DEQHKHVEAELRSRLATLETE-------AAQ 107
              E L K     ER    +  QF E    DEQ   +  +L  + A L+T+         +
Sbjct: 1240 --EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297

Query: 108  HQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG 167
             ++++  LT+      ++L+  K ++E +++     A   +    +C L  +   E+   
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 168  R--LEESLSIINEKVPFNDTKYSQYNAL--NVPLHNRRHQLKMRDIAGQALAFVQDLVTA 223
            +  L+ +LS  N +V    TKY + +A+     L   + +L  R    +      +   A
Sbjct: 1358 KAELQRALSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416

Query: 224  LLNFHTYTEQRIQ------IFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFE 277
             L     T+QR+Q      +  ++ +    + L++K   +    A + + L+E    L E
Sbjct: 1417 SLE---KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL-E 1472

Query: 278  SITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLE 337
            +  +++ ++     K++   E +   +  LR+    + K+L+EE        A   +NL+
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRR----ENKNLQEEISDLTEQIAETGKNLQ 1528

Query: 338  LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISK 397
             ++  KK+    EK    +AL      E +G L    S +L  V   L     V  ++ +
Sbjct: 1529 EAEKTKKLVEQ-EKSDLQVAL-----EEVEGSLEHEESKIL-RVQLEL---SQVKSELDR 1578

Query: 398  HYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPK 457
               +K     +L   +Q+       +L + +   N A ++      +L+     L +  +
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNR 1638

Query: 458  AASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGL-- 515
                      AE   ++ +     +K  +  L +++   E L  +   L+  E R GL  
Sbjct: 1639 Q--------MAETQ-KHLRTVQGQLKDSQLHLDDALRSNEDLKEQ---LAIVERRNGLLL 1686

Query: 516  --AQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 573
               ++++ +LE+  +  +  E  +L+A      L  +N  + +  K   +      A+  
Sbjct: 1687 EELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE 1746

Query: 574  AAVSNTAGQDEATAKAV---------LEPIQSTSL-IGTLTRTSDSEVPDVESR----ED 619
             ++  +   +E   KA+         L+  Q TS  +  + +  +  V D++ R    E 
Sbjct: 1747 NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806

Query: 620  LIKNHYMARIVELTSQL-QLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI 678
            L       +I +L +++ +L +   V       AL        K KE +T + +   +NI
Sbjct: 1807 LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKE-MTYQAEEDHKNI 1865

Query: 679  SRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSK----QREEIDTLKMSSKGNSKKN 731
             RLQ   D+L    +SY+ Q     +     N  LS+    Q E  +  + +    S+ N
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEE---QANTQLSRCRRVQHELEEAAERADIAESQVN 1922

Query: 732  KSR 734
            K R
Sbjct: 1923 KLR 1925



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 151/760 (19%), Positives = 296/760 (38%), Gaps = 120/760 (15%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            K+  L +LQ ++D     +LQ  K+++ LQ  +   E    +  ++  +     ++Q+S 
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE----EEIEAEHTLRAKIEKQRSD 1142

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
               +L++  E  E          E +K  EAE +     LE    QH+A    L +K  +
Sbjct: 1143 LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVP 181
            ++ +L      L+   Q LEKE  E ++  ++    ++ L +  S  +E +   + +   
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS-NIERTCRTVED--- 1258

Query: 182  FNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVD 241
                ++S+  A +       H L M+                        + R+Q     
Sbjct: 1259 ----QFSEIKAKDEQQTQLIHDLNMQ------------------------KARLQ----- 1285

Query: 242  SAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLT 301
                     N + S  + E  S +  L +    L + + E+    +E   K K    H  
Sbjct: 1286 -------TQNGELSHRVEEKESLISQLTKSKQALTQQL-EELKRQMEEETKAKNAMAHAL 1337

Query: 302  SYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ-------DMKKMTAVFEKLQT 354
                    +L  Q +  E+E ++ L   AL   N E++Q       D  + T   E+ + 
Sbjct: 1338 QSSRHDCDLLREQYEE-EQEAKAEL-QRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395

Query: 355  YIALLALPSTEPDGLLRTNYSSVLTNVGAALHG-FHDVMKDISKHYSQKAAIEHELPTAT 413
             +A   L   E +     +  + L      L G   D+M+D+ + ++  A ++ +     
Sbjct: 1396 KLA-QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK----- 1449

Query: 414  QKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ 473
                                  K+ + +   LD   A L    K +    + L    M  
Sbjct: 1450 -----------------QRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFK--MRN 1490

Query: 474  YKKKAAAYMKSLR---KPLLESV-PYEEALANRRILLSSTESREGLAQQVQQSLE-KISK 528
              ++    +++LR   K L E +    E +A     L   E  + L +Q +  L+  + +
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550

Query: 529  LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAK 588
            +E   EH   E+++ +++LE        ++K+    +++   +E   +   + +     +
Sbjct: 1551 VEGSLEH--EESKILRVQLE------LSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQ 1602

Query: 589  AVLE-PIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVE--LTSQLQLADSKSVH 645
            +VL+  I+S +    L +  + ++ ++E +     N  MA   +   T Q QL DS+ +H
Sbjct: 1603 SVLDAEIRSRNDALRLKKKMEGDLNEMEIQLG-HSNRQMAETQKHLRTVQGQLKDSQ-LH 1660

Query: 646  FYAECRA---LSKRLALAEKSKEAL---TEEMKLASQNISRLQDELTTTKRSYEDQLSMM 699
                 R+   L ++LA+ E+    L    EEMK+A +   R       T+R  E +L   
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTER-------TRRLSEQELLDA 1713

Query: 700  SDH---LCSMNETL--SKQREEIDTLKMSSKGNSKKNKSR 734
            SD    L S N +L  +K++ E D  +  ++  +   +SR
Sbjct: 1714 SDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 27/144 (18%)

Query: 613  DVESR-EDLIKNHYM--ARIVELTSQLQLADSKSVHFYAECRALSKR------------- 656
            D E R E LIK+  +  A++ ELT +L+  +  +    A+ R L  +             
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963

Query: 657  -LALAEKSKEA-------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCS 705
             L   EK K A       L+EEM    +NIS+L  E  + + +++   D L +  D +  
Sbjct: 964  TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023

Query: 706  MNETLSKQREEIDTLKMSSKGNSK 729
            + +  +K  ++ D L+ S +   K
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKK 1047



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 45/215 (20%), Positives = 91/215 (42%), Gaps = 10/215 (4%)

Query: 508  STESR-EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQL 566
            +TE++ + L++++    E ISKL +EK+      Q     L+ E  ++   +K       
Sbjct: 974  ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK--- 1030

Query: 567  VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 626
              L Q+   +  +  Q E   +A LE  +   L G L  + +S + D+E+ +  I+    
Sbjct: 1031 --LEQQTDDLEGSLEQ-EKKLRADLERAKR-KLEGDLKMSQES-IMDLENDKQQIEEKLK 1085

Query: 627  ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 686
             +  EL+      D + VH     + + +  A  E+ +E +  E  L ++ I + + +L 
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK-IEKQRSDLA 1144

Query: 687  TTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK 721
                   ++L   S    +  E   K+  E   ++
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 4/86 (4%)

Query: 631 ELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKR 690
           +L  Q+Q      +     C  L K   L E   + LTE ++   +    +  EL   KR
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEE----MNSELVAKKR 945

Query: 691 SYEDQLSMMSDHLCSMNETLSKQREE 716
           + ED+ S +   +  +  TL+K  +E
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKE 971


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 150/776 (19%), Positives = 303/776 (39%), Gaps = 77/776 (9%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKS----GESSSQLSQEQ 58
            +  L +++ E  S+    L L   +E++Q E    E   +  +K      E  S ++ E+
Sbjct: 1901 ENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSER 1960

Query: 59   KSVFDE--DLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLT 116
              +  E   + KK    ++L  +  E  ++ +  ++E    +   E E  +   ++  L+
Sbjct: 1961 NQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLS 2020

Query: 117  RKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSII 176
                  + +L  DK  L+ K Q+LEK+++   L   E + Q+  L+++    ++ES S+ 
Sbjct: 2021 ----SDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076

Query: 177  NEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQ 236
                       S Y  LNV        ++  + A + L+  Q+ V  L        + I+
Sbjct: 2077 AR------LSESDYEKLNVSKALEAALVEKGEFALR-LSSTQEEVHQL-------RRGIE 2122

Query: 237  IFPVDSAIDTISPLN--QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 294
               V    D    L+  +K  +   EN S    +E     L  S     + +L+      
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKA 2182

Query: 295  TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVF----- 349
                  T      R +  ++L  +    E    T  ++ +  +LS+ + K+ + F     
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE-LDKLLSSFKSLLE 2241

Query: 350  EKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHEL 409
            EK Q  I +     T  + L   N    L    AAL G  ++MK   +        EH+L
Sbjct: 2242 EKEQAEIQIKEESKTAVEML--QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQL 2299

Query: 410  PTATQKLITTND-------CILSSVVALTNGAGKIASFFSN-NLDYFIASLSYGPKAASG 461
              + +KL    +       C+L  +    + A  +     N   +  IA  +    A   
Sbjct: 2300 RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA 2359

Query: 462  FISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ 521
              S    E +   K K     +SLR   L+ V       N    L   + R    + +  
Sbjct: 2360 ENSKGEVETL---KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416

Query: 522  SLEKI-SKLEQE----KEHWMLEAQLAKIKLEKENQRIAD--------KLKNTG-SAQLV 567
            S E I  + EQE    KE      ++ + +L++ N+R+A         K K    S+Q+ 
Sbjct: 2417 SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE 2476

Query: 568  GLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDL--IKN-- 623
             L  E A +    G DEA    +   +  +S+ G +    D +    +  E++  +KN  
Sbjct: 2477 CLELEKAQL--LQGLDEAKNNYI---VLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2531

Query: 624  ----HYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNIS 679
                  ++++ ++  + QL   +++        L +++ + +    +L + +++   +  
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK 2591

Query: 680  RLQDELTTT---KRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNK 732
             L++EL  T   K S+ ++++ M+     +   + +  ++  T ++  + + +KN+
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK--TAELQEELSGEKNR 2645



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 71/314 (22%), Positives = 127/314 (40%), Gaps = 48/314 (15%)

Query: 39   PRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEE----NERLHIQFFEADEQHKHVEAEL 94
            P+     ++   S + S E +   + DLQK+ EE       +     +A++ H+   AE 
Sbjct: 822  PKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET 881

Query: 95   RSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLE------KEAKECR 148
              R++ L+ + + HQ VV        ET+  L+N + +L++ +  +E      +E K+  
Sbjct: 882  SQRISKLQEDTSAHQNVV-------AETLSALENKEKELQLLNDKVETEQAEIQELKKSN 934

Query: 149  LRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRD 208
               E+   +L+ L E LS   +E  SII+     N  +  +    N  L      L    
Sbjct: 935  HLLEDSLKELQLLSETLSLEKKEMSSIIS----LNKREIEELTQENGTLKEINASLNQEK 990

Query: 209  IAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPL 268
            +         +L+    +F  Y ++R      + +I  +S       QY  E    ++  
Sbjct: 991  M---------NLIQKSESFANYIDER------EKSISELS------DQYKQEKLILLQRC 1029

Query: 269  EEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSL----EEECES 324
            EE   + +E +++      E   KL+      TS +C  RK    QLK       +E  +
Sbjct: 1030 EE-TGNAYEDLSQKYKAAQEKNSKLECLLNECTS-LCENRKNELEQLKEAFAKEHQEFLT 1087

Query: 325  SLCTSALRARNLEL 338
             L  +  R +NL L
Sbjct: 1088 KLAFAEERNQNLML 1101



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 155/765 (20%), Positives = 292/765 (38%), Gaps = 102/765 (13%)

Query: 28   ELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKK--IEENERLHIQFFEADE 85
            ELL+D+  L E      K S   S    + +  +   + +K+  ++E+E L  +  E+D 
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084

Query: 86   QHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAK 145
            +  +V   L + L      A +  +          E + +L+    KL V+ +  EK+  
Sbjct: 2085 EKLNVSKALEAALVEKGEFALRLSST--------QEEVHQLRRGIEKLRVRIEADEKKQL 2136

Query: 146  ECRLRTEECQLQLKTLHEDLSGRLEE-SLSIINEKVPFNDTKYSQYNALNVPLHNRRHQL 204
                + +E + +  +L + +     E  +S  N+++   D + S+     +       + 
Sbjct: 2137 HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL-------KT 2189

Query: 205  KMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASY 264
            ++ ++A     F  DLVT        T+Q   I      +  +  L   F   L E    
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQ---IQEKQGQLSELDKLLSSFKSLLEEK--- 2243

Query: 265  VRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSL----EE 320
                E+  + + E  ++  V +L+   +LK  +E + + +C  ++I+    +SL    EE
Sbjct: 2244 ----EQAEIQIKEE-SKTAVEMLQN--QLKELNEAVAA-LCGDQEIMKATEQSLDPPIEE 2295

Query: 321  ECESSLCTSALRARNLELSQDMKKMTAVFEKLQT---YIALL-------------ALPST 364
            E +       LRAR   L  D KK   V ++L+    +  LL             A  + 
Sbjct: 2296 EHQLRNSIEKLRAR---LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352

Query: 365  EPDGLLRTNYSSVLTNVGAALHGFHDVMK----DISKHYSQKAAIEHELPTATQKLITTN 420
            E   L   N    +  + A + G    ++    D+    S+K  + +EL    Q+ I+  
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE-QERISEL 2411

Query: 421  DCILSSVVAL--------------TNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPL 466
            + I SS   +              ++ A ++       L+  +A+L    +A       L
Sbjct: 2412 EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2471

Query: 467  SA--ECMLQYKKKAAAYMKSLRKP---LLESVP--YEEALANRRILLSSTESREGLAQQV 519
            S+  EC+   K +    +   +     L  SV    +E    ++ L    E    L  Q+
Sbjct: 2472 SSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQI 2531

Query: 520  QQSLEKISKLEQ-EKEHWMLEAQ---LAKIKLEKENQRIADKLKNTGSAQLVGLAQENAA 575
            Q   + +SKL Q E EH + + Q   L  + +E E +    + KN      + + Q  ++
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQ--SS 2589

Query: 576  VSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV-----ESREDLI--KNHYMAR 628
              N   + E T    +  ++  + +         E+ ++     E +E+L   KN     
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649

Query: 629  IVELTSQLQLADSKSVHFYAECRALSKRLALAEKS--------KEALTEEMKLASQNISR 680
            +  L  +++ +  +      E   L K L    K         +E + E      +   +
Sbjct: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKK 2709

Query: 681  LQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 725
             Q  L  T + YE ++    + L S  E LS Q+ EID LK S +
Sbjct: 2710 HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE 2754



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 75/366 (20%), Positives = 143/366 (39%), Gaps = 60/366 (16%)

Query: 3    DQSLRKLQQEMDSLTFRNLQLAKRVELLQDE---LALSEPRGKKNKKSGESSSQLSQEQK 59
            ++ +  L  + ++   +   L+ +VE L+ E   L       K N    +SS     ++ 
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510

Query: 60   SVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKY 119
                + L+KK EE  RL  Q  + ++        L S+L+ +E E   HQ         +
Sbjct: 2511 EDGKQKLEKKDEEISRLKNQIQDQEQ--------LVSKLSQVEGE---HQL--------W 2551

Query: 120  METIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEK 179
             E   +L+N   +LE K Q L+ +    +   E  Q   K L  +L     + +S +   
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE-- 2609

Query: 180  VPFNDTKYSQYNALNVPLHNRRHQLKMR------DIAGQALAFVQDLVTALLNFHTYTEQ 233
                  K ++  A    L    H++  +      +++G+      +L   L    +  +Q
Sbjct: 2610 ------KVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663

Query: 234  RIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETT--- 290
              ++   +S +     L+      + +       + E  L L E+  +    +L+T    
Sbjct: 2664 LKELTLENSELK--KSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQY 2721

Query: 291  -VKLKTFSEHLTSYICFLRKILPYQLKSLEEECESS--LCTSALRARNLELSQDMKKMTA 347
             V+++T+ E LTS                +EEC SS  L    L++   EL+  +K  T 
Sbjct: 2722 EVEIQTYREKLTS----------------KEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765

Query: 348  VFEKLQ 353
            + E+L+
Sbjct: 2766 ILEELK 2771



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 149/779 (19%), Positives = 305/779 (39%), Gaps = 103/779 (13%)

Query: 9    LQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQK 68
            LQ E+D LT    QL   +E  + +L  +E            + Q SQ +++     +++
Sbjct: 435  LQAELDKLTSVKQQLENNLEEFKQKLCRAE-----------QAFQASQIKENELRRSMEE 483

Query: 69   KIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRK--YMETIEKL 126
              +EN  L     +   +  H+EAEL++    L     Q Q   + +  K    ET+ + 
Sbjct: 484  MKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN----QSQNFAEEMKAKNTSQETMLRD 539

Query: 127  QNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTK 186
              +K   +  S TLEK     +L   + + Q +   +DL  + E  +  +N+K+  + T+
Sbjct: 540  LQEKINQQENSLTLEK----LKLAVADLEKQ-RDCSQDLLKKREHHIEQLNDKL--SKTE 592

Query: 187  YSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDT 246
                  L+     ++   ++++       +  +      N    T+   +   + S I+ 
Sbjct: 593  KESKALLSALELKKKEYEELKEEKTLFSCWKSE------NEKLLTQMESEKENLQSKINH 646

Query: 247  ISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICF 306
            +    +      HE    VR LE    +L   I      +   +V+++T      +Y+  
Sbjct: 647  LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET---QKLAYMEL 703

Query: 307  LRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMT-AVFEKLQTYIALLALPSTE 365
             +K      K  +E     L TS L  +  +L   ++ ++  + +K + Y  L A   + 
Sbjct: 704  QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL 763

Query: 366  PDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKL----ITTND 421
             D LL++  +S++TN         D  + +   + Q+ A+ H       +        ++
Sbjct: 764  RD-LLKSKDASLVTN--------EDHQRSLLA-FDQQPAMHHSFANIIGEQGSMPSERSE 813

Query: 422  CILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC--MLQYK---- 475
            C L +     + + K ++   N +D    SL +  ++     S L  +C  ++Q K    
Sbjct: 814  CRLEA-----DQSPKNSAILQNRVD----SLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864

Query: 476  ---KKAAAYMKSLRKPLLESVP--YEEALANRRILLSSTESREGLAQQVQQSLEKISKLE 530
                KA    +S      + +    E+  A++ ++  +  + E   +++Q   +K+   +
Sbjct: 865  ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924

Query: 531  QE-----KEHWMLEAQLAKIKLEKENQRIADK----LKNTGSAQLVGLAQENAAVSNTAG 581
             E     K + +LE  L +++L  E   +  K    + +    ++  L QEN  +     
Sbjct: 925  AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984

Query: 582  QDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLI---KNHYMARIVELTSQ--- 635
                    +++  +S +        S SE+ D   +E LI   +        E  SQ   
Sbjct: 985  SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYK 1044

Query: 636  -LQLADSKSVHFYAECRAL-SKRLALAEKSKEALTEE-----MKLA-----SQNI----- 678
              Q  +SK      EC +L   R    E+ KEA  +E      KLA     +QN+     
Sbjct: 1045 AAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE 1104

Query: 679  ---SRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
                 L+ E+T  + + + +   +   + ++ E  +K ++E++ L   ++   K  K++
Sbjct: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTK 1163



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 51/236 (21%), Positives = 91/236 (38%), Gaps = 33/236 (13%)

Query: 507 SSTESREGLAQQVQQSLEKISKLE-------QEKEHWMLEAQLAKIKLEKENQRIADKLK 559
           SS    + L  Q Q+   KI++LE       +E +  + + Q  +++LEK    + +K K
Sbjct: 275 SSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK 334

Query: 560 NTGSAQLVGLAQENAAVSNTAGQDEATAK-AVLEPIQSTSLIGTLTRTSDSEVPDVESRE 618
                +       +  V  TA  D+A+ K   LE       +  LT     +  + ES  
Sbjct: 335 VLNKCR-------DELVRTTAQYDQASTKYTALE-----QKLKKLTEDLSCQRQNAESAR 382

Query: 619 DLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI 678
             ++     +  E   +L            EC  +  RL          T+E++ A    
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL----------TQELQQAKNMH 432

Query: 679 SRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKN 731
           + LQ   D+LT+ K+  E+ L      LC   +     + + + L+ S +   K+N
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN 488



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 40/189 (21%), Positives = 83/189 (43%), Gaps = 22/189 (11%)

Query: 8   KLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGES-SSQLSQEQKSVFDEDL 66
           K+ Q+ +SLT   L+LA  V  L+ +   S+   KK +   E  + +LS+ +K    + L
Sbjct: 543 KINQQENSLTLEKLKLA--VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE--SKAL 598

Query: 67  QKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKL 126
              +E  ++ + +  E        ++E    L  +E+E    Q+ ++     ++ET  K 
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN-----HLETCLKT 653

Query: 127 QNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEE------SLSIINEKV 180
           Q      ++KS    +  +   +  E   ++++ LH  L  +  E      +   + +K 
Sbjct: 654 Q------QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKA 707

Query: 181 PFNDTKYSQ 189
            F+D K+ +
Sbjct: 708 EFSDQKHQK 716


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 136/738 (18%), Positives = 282/738 (38%), Gaps = 50/738 (6%)

Query: 2    KDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            KD    +LQ +++      LQ  K+++ LQ  +   E    +  ++  ++   +++Q+S 
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE----EEIEAERATRAKTEKQRSD 1139

Query: 62   FDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME 121
            +  +L++  E  E          E +K  EAE       LE    QH+A+V  L +K+ +
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199

Query: 122  TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH------EDLSGRLEESLSI 175
            ++ +L      L+   Q LEKE  E +L  ++    ++++       E +   LE+ LS 
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259

Query: 176  INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ-R 234
               K        S+       L     +L  +    +  + V  L  +   F   TE+ +
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKESIVSQLSRSKQAFTQQTEELK 1317

Query: 235  IQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 294
             Q+   + A + ++   Q                +EG   L  ++++    V +   K +
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1377

Query: 295  TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQT 354
            T +   T  +   +K L  +L+  EE+ E      A+ A+   L +  +++    E L  
Sbjct: 1378 TDAIQRTEELEEAKKKLAQRLQDSEEQVE------AVNAKCASLEKTKQRLQGEVEDLMV 1431

Query: 355  YIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ 414
             +      +   D   R N+  VL                  K   +++  E E      
Sbjct: 1432 DVERANSLAAALDKKQR-NFDKVLAE---------------WKTKCEESQAELEASLKES 1475

Query: 415  KLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQY 474
            + ++T    L +         +     + NL+  IA L+         I  L  +   Q 
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE-KSRKQI 1534

Query: 475  KKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKE 534
            + + A    +L +   E+    E     RI L  T+ +  + +++ +  E+I +L++  +
Sbjct: 1535 ELEKADIQLALEE--AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592

Query: 535  HWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPI 594
               +E   + +  E  ++  A +LK      L  +  + +  +  A +     ++V   +
Sbjct: 1593 R-TVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651

Query: 595  QSTSL-IGTLTRTSD---SEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAEC 650
            + T L +    R  +    ++  VE R +L++    A + EL + L+  +        E 
Sbjct: 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANLLQ----AEVEELRATLEQTERARKLAEQEL 1707

Query: 651  RALSKRLALAEKSKEALTEEMKLASQNISRLQDEL---TTTKRSYEDQLSMMSDHLCSMN 707
               ++R+ L      +L    K    ++ +LQ E+   +   R+ E++          M 
Sbjct: 1708 LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMA 1767

Query: 708  ETLSKQREEIDTLKMSSK 725
            E L K+++    L+   K
Sbjct: 1768 EELKKEQDTSAHLERMKK 1785



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 153/762 (20%), Positives = 288/762 (37%), Gaps = 107/762 (14%)

Query: 9    LQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DL 66
            L   M+S++     L K    L+D+L  SE RGK N++   S S+L+ ++  +  E  +L
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQL--SEARGK-NEEIQRSLSELTTQKSRLQTEAGEL 1288

Query: 67   QKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRK------YM 120
             +++EE E +  Q   + +       EL+ +L   E E     A+   L           
Sbjct: 1289 SRQLEEKESIVSQLSRSKQAFTQQTEELKRQL---EEENKAKNALAHALQSSRHDCDLLR 1345

Query: 121  ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
            E  E+ Q  KA+L+        E  + R + E   +Q        +  LEE+   + +++
Sbjct: 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR-------TEELEEAKKKLAQRL 1398

Query: 181  PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240
              ++ +    NA    L   + +L+           V+DL+                  V
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGE---------VEDLMV----------------DV 1433

Query: 241  DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300
            + A    + L++K   +    A +    EE    L  S+ E      E   KLK   E  
Sbjct: 1434 ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL-FKLKNAYEEA 1492

Query: 301  TSYICFLRKILPYQLKSLEEECESSLCTSALRARNL-ELSQDMKKMTAVFEKLQTYIALL 359
               +  +++    + K+LE+E        A   + + EL +  K++    EK    +AL 
Sbjct: 1493 LDQLETVKR----ENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE--LEKADIQLAL- 1545

Query: 360  ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 419
                 E +  L    + +L  +   L     V  +I +  ++K     +L    Q+ + T
Sbjct: 1546 ----EEAEAALEHEEAKIL-RIQLELT---QVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597

Query: 420  NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA 479
                L + V   N A ++      +L+     LS+  + A+           L++ +   
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE---------TLKHLRSVQ 1648

Query: 480  AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQ----QVQQSLEKISKLEQEKEH 535
              +K  +  L +++  +E L  +   L+  E R  L Q    +++ +LE+  +  +  E 
Sbjct: 1649 GQLKDTQLHLDDALRGQEDLKEQ---LAIVERRANLLQAEVEELRATLEQTERARKLAEQ 1705

Query: 536  WMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAV----- 590
             +L++      L  +N  +    K      L+ L  E    S  A   E  AK       
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKL-ETDLMQLQSEVEDASRDARNAEEKAKKAITDAA 1764

Query: 591  -----LEPIQSTSL-IGTLTRTSDSEVPDVESREDLIKNHYM-----------ARIVELT 633
                 L+  Q TS  +  + +  +  V D++ R D  +   +            RI EL 
Sbjct: 1765 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824

Query: 634  SQLQLADSKSVHFYAECRALSKRLA-LAEKSKEALTEEMKLASQNISRLQDELTTTKRSY 692
             +L+    K+       R   +R+  L  +S+E     ++L    + +LQ ++ + KR  
Sbjct: 1825 FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL-VDKLQVKVKSYKRQA 1883

Query: 693  EDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 734
            E+     + HL    +    Q E  +  + +    S+ NK R
Sbjct: 1884 EEADEQANAHLTKFRKA---QHELEEAEERADIAESQVNKLR 1922



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 139/734 (18%), Positives = 276/734 (37%), Gaps = 101/734 (13%)

Query: 31   QDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHV 90
            +DELA SE    K K+  E    L QE+      DLQ +++      +   E  +Q    
Sbjct: 861  KDELAKSEA---KRKELEEKLVTLVQEKN-----DLQLQVQAESENLLDAEERCDQLIKA 912

Query: 91   EAELRSRLATLETEAAQHQAVVDGLT---RKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 147
            + +L +++  +   A   + +   LT   RK  +   +L+ D   LE+    +EKE    
Sbjct: 913  KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE---- 968

Query: 148  RLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR 207
            +  TE    ++K L E+LSG  E    +  EK    +                 HQ  + 
Sbjct: 969  KHATEN---KVKNLTEELSGLDETIAKLTREKKALQEA----------------HQQALD 1009

Query: 208  DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRP 267
            D+  +     +D V +L    +  EQ+++   ++S+++    L     +   +    ++ 
Sbjct: 1010 DLQAE-----EDKVNSLNKTKSKLEQQVE--DLESSLEQEKKLRVDLERNKRKLEGDLKL 1062

Query: 268  LEEGMLHLFESITEDTVTVLETTVKLKTF---------SEHLTSYICFLRKI--LPYQLK 316
             +E +L L     E+    L+  +K K F          +  T  + F +KI  L  +++
Sbjct: 1063 AQESILDL-----ENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIE 1117

Query: 317  SLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSS 376
             LEEE E+   T A   +  + S   +++  + E+L+           E  G+  T    
Sbjct: 1118 ELEEEIEAERATRAKTEK--QRSDYARELEELSERLE-----------EAGGVTSTQIEL 1164

Query: 377  VLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGK 436
                    L    D+ +   +H +  AA+  +   +  +L    D    ++  +     K
Sbjct: 1165 NKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID----NLQRVKQKLEK 1220

Query: 437  IASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYE 496
              S F   +D   +S+    K+ +          +     +A    + +++ L E    +
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANL--EKICRTLEDQLSEARGKNEEIQRSLSELTTQK 1278

Query: 497  EALANRRILLS-STESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLE---KENQ 552
              L      LS   E +E +  Q+ +S +  ++  +E +  + E   AK  L    + ++
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338

Query: 553  RIADKLKNTGSAQLVGLAQENAAVSNTAGQ-DEATAKAVLEPIQSTSLIGTLTRTSDSEV 611
               D L+     +  G A+   A+S    +  +   K   + IQ T  +    +     +
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398

Query: 612  PDVESREDLI----------KNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAE 661
             D E + + +          K      + +L   ++ A+S +     + R   K LA  +
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458

Query: 662  KSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSM----------MSDHLCSMNETLS 711
               E    E++ + +    L  EL   K +YE+ L            +   +  + E ++
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518

Query: 712  KQREEIDTLKMSSK 725
            +  + I  L+ S K
Sbjct: 1519 ENGKTIHELEKSRK 1532



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 51/248 (20%), Positives = 99/248 (39%), Gaps = 31/248 (12%)

Query: 505  LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSA 564
            L S  E  + L  Q Q+ ++++    +E E  +   +  + K EK+    A +L+     
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE----- 1145

Query: 565  QLVGLAQENAAVSNTAGQDEATAKAVLE-----------PIQSTSLIGTLTRTSDSEVPD 613
            +L    +E   V++T  Q E   K   E            +Q  +++  L +     V +
Sbjct: 1146 ELSERLEEAGGVTST--QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203

Query: 614  VESREDLI----------KNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKS 663
            +  + D +          K+ +   I +L+S ++       +    CR L  +L+ A   
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263

Query: 664  KEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMS 723
             E +   +   +   SRLQ E     R  E++ S++S  L    +  ++Q EE+   +  
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS-QLSRSKQAFTQQTEELK--RQL 1320

Query: 724  SKGNSKKN 731
             + N  KN
Sbjct: 1321 EEENKAKN 1328



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 2/112 (1%)

Query: 605 RTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSK 664
           +T D        R++L +   +  +V+  + LQL          +      +L  A+   
Sbjct: 859 KTKDELAKSEAKRKELEEK--LVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQL 916

Query: 665 EALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREE 716
           EA  +E+   +++   +  ELT  KR  ED+ S +   +  +  TL+K  +E
Sbjct: 917 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 968



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 22/101 (21%), Positives = 45/101 (44%)

Query: 4    QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFD 63
            + LRK ++ +  LT+++ +  K V  LQD +   + + K  K+  E + + +    + F 
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR 1898

Query: 64   EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETE 104
            +   +  E  ER  I   + ++          SR+   E+E
Sbjct: 1899 KAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 157/766 (20%), Positives = 319/766 (41%), Gaps = 91/766 (11%)

Query: 5    SLRKLQQEMDSLTFRNLQLAKRVELL---QDELALSEPRGKKNKKSGESSSQLSQEQKSV 61
            S ++L  E+++ T +NLQ    V LL   Q +  L E  GK N  + E    +++ + S 
Sbjct: 549  SQQELVPELEN-TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSH 607

Query: 62   FDED-LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLE---TEAAQHQAVVDGLTR 117
             + D   KK E  ERL ++  +  EQ     +EL  ++  L     E  + +   D    
Sbjct: 608  EEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLE 667

Query: 118  KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGR----LEESL 173
            K M  ++ L  DK  L  + ++L +E    +L +E+ QL  + L   LS +    L+E +
Sbjct: 668  KLMVQMKVLSEDKEVLSAEVKSLYEENN--KLSSEKKQLS-RDLEVFLSQKEDVILKEHI 724

Query: 174  SIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ 233
            + + +K+        + + LN  L N   Q++   +  Q   F++++ + +      +E+
Sbjct: 725  TQLEKKLQL---MVEEQDNLNKLLENE--QVQKLFVKTQLYGFLKEMGSEVSED---SEE 776

Query: 234  RIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKL 293
            +  +  + +  ++++ +N++      +    V  LE+ +    + + E++V   E   +L
Sbjct: 777  KDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEI----KCLQEESVVQCE---EL 829

Query: 294  KTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQ 353
            K+           LRK    +L+ ++ E E+             L  D+ +M    EK +
Sbjct: 830  KSLLRDYEQEKVLLRK----ELEEIQSEKEA-------------LQSDLLEMKNANEKTR 872

Query: 354  TYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH-ELPTA 412
                 L +   E   + +T   S + N              I +H + K  +E  EL   
Sbjct: 873  LENQNLLIQVEE---VSQTCSKSEIHNEKEKCF--------IKEHENLKPLLEQKELRDR 921

Query: 413  TQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECML 472
              +LI   D +  S     +    +       L+  I +L    K     I+ +    + 
Sbjct: 922  RAELILLKDSLAKSPSVKNDPLSSV-----KELEEKIENLEKECKEKEEKINKIKLVAV- 975

Query: 473  QYKKKAAAYMKSLR--KPLLESVPYE--EALANRRILLSSTESREGLAQQVQQSLEKISK 528
            + KK+  +  K  +  K  LES+  E  +  A+ R L+   ES + L  + ++  E++  
Sbjct: 976  KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD- 1034

Query: 529  LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVG---LAQENAAVSNTAGQDEA 585
            +E+E+ +   E ++  +  +  N  +  +  N+ +  L+      Q NA +      +  
Sbjct: 1035 VEKERAN-NFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1093

Query: 586  TAKAVL------EPIQSTSLIG----TLTRTSDSEVPDVESREDLIKNHYMARIVELTSQ 635
             AKA++      E +Q    I     T+    + +V   + ++ L K      +V+  +Q
Sbjct: 1094 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQ 1153

Query: 636  LQLADSKSVHFYAEC-RALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRS--- 691
                 +  +  Y    + L+++L       E L +E+K+  Q    LQ+E+T+ + S   
Sbjct: 1154 QTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQ 1213

Query: 692  YEDQLSMMSDHLCSMNETLSKQRE-EID--TLKMSSKGNSKKNKSR 734
            YE++ + +   L    + L+  ++ E D   L+ S KG  + ++ +
Sbjct: 1214 YEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQ 1259



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 156/810 (19%), Positives = 307/810 (37%), Gaps = 124/810 (15%)

Query: 3   DQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVF 62
           + S+ K+      L   ++   K +E L++EL           K  E  + L ++     
Sbjct: 107 EDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVR------SKYSEDKANLQKQ----L 156

Query: 63  DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 122
           +E +  ++E +E+L  Q   +++  K ++ E+       E +    Q  +D  T +  ET
Sbjct: 157 EEAMNTQLELSEQLKFQN-NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKET 215

Query: 123 IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPF 182
           + +LQN    +E  SQ  +K         +E  LQLK +H++    ++E +  I      
Sbjct: 216 VTQLQN---IIEANSQHYQKNINS----LQEELLQLKAIHQE---EVKELMCQIEASAKE 265

Query: 183 NDTKYSQYNALNVPL----------HNRRHQLKMRDIAGQALAFVQD--LVTALLNFHTY 230
           ++ + ++ N L   L            ++++ ++ ++        QD  + + LL  +T+
Sbjct: 266 HEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 325

Query: 231 TEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPL-----------EEGMLHLFESI 279
            EQ +    V    DT+  L  + S  L +  +Y+  L           ++   H  E +
Sbjct: 326 VEQVVN-EKVKHLEDTLKELESQHS-ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL 383

Query: 280 ----------TEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTS 329
                      E+   V+E   KLK+    L    C+  +    +++SL+E+ +  +  S
Sbjct: 384 EFKINELLLAKEEQGCVIE---KLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEI--S 438

Query: 330 ALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFH 389
            L    L    + +K+T +FE          L   + + +L  NY S+   +        
Sbjct: 439 ELNETFLS-DSEKEKLTLMFEIQGLKEQCENLQQEKQEAIL--NYESLREIMEILQTELG 495

Query: 390 DVMKDISKHY----SQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIAS------ 439
           +    IS+ +     Q+A+  HEL    +   T  D +L +V  L     K+ S      
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555

Query: 440 -------FFSNNLDYFIASLSYGP---KAASGFISPLSAE--CMLQYKKKAAAYMKSLRK 487
                          ++ SLS      K   G I+ L+ E    +   K +   M +  K
Sbjct: 556 ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK 615

Query: 488 PLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKL 547
                    +     R++L   +  E   Q   +  +K+++L    E  + E      KL
Sbjct: 616 ---------KCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL 666

Query: 548 EK--ENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTR 605
           EK     ++  + K   SA++  L +EN  +S+   Q     +  L   +   L   +T+
Sbjct: 667 EKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQ 726

Query: 606 TSDSEVPDVESREDLIKNHYMARIVELTSQLQL------------ADSKSVHFYAECRAL 653
                   VE +++L K     ++ +L  + QL             DS+        +A+
Sbjct: 727 LEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAV 786

Query: 654 SKRLALAEKSK-----------EALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDH 702
            + LA   + K             L +E+K   +      +EL +  R YE +  ++   
Sbjct: 787 GESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKE 846

Query: 703 LCSMNETLSKQREEIDTLKMSSKGNSKKNK 732
           L    E +  ++E + +  +  K  ++K +
Sbjct: 847 L----EEIQSEKEALQSDLLEMKNANEKTR 872



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 158/782 (20%), Positives = 297/782 (37%), Gaps = 110/782 (14%)

Query: 3   DQSLRKLQQEMDSLT----FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQ 58
           + +++KLQ+E++ +      + L L K+++   DE    +    + +   E++SQ  Q+ 
Sbjct: 177 EDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE---KKETVTQLQNIIEANSQHYQKN 233

Query: 59  -KSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTR 117
             S+ +E LQ K    E +     + +   K  EAE+       E    Q +A    + +
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293

Query: 118 KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIIN 177
           KY   +E L+   +     +Q      +E     +    ++K L ED    LE   SI+ 
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL-EDTLKELESQHSILK 352

Query: 178 EKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI 237
           ++V +        N L + L     ++  + I  +     +DL   +       E+  Q 
Sbjct: 353 DEVTY-------MNNLKLKL-----EMDAQHIKDEFFHEREDLEFKINELLLAKEE--QG 398

Query: 238 FPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFS 297
             ++     ++ LN++F   + ++   V+ L+E      + I+E   T L  + K     
Sbjct: 399 CVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE---QHQKEISELNETFLSDSEK----- 450

Query: 298 EHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIA 357
           E LT         L ++++ L+E+CE+      L+    E   + + +  + E LQT + 
Sbjct: 451 EKLT---------LMFEIQGLKEQCEN------LQQEKQEAILNYESLREIMEILQTELG 495

Query: 358 LLA-LPSTEPDGLLRTNYSSV----------LTNVGAALHGFHDVMKDISKHYSQKAAIE 406
             A   S E + + +   S V           T   A L   + +  +  K  SQ+  + 
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555

Query: 407 HELPTATQKLITTNDCILSSV----VALTNGAGKIASFFSNNLDYFIASLSYGPKAASGF 462
            EL    + L   N   L S+      L    GKI S  +   D FI  L    +    F
Sbjct: 556 -ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINS-LTEEKDDFINKLKNSHEEMDNF 613

Query: 463 ISPL------------SAECMLQYKKKAAAYMKSLRKPLLESV--------PYEEALANR 502
                             E  +QY  +    +  L   L E++          E+ +   
Sbjct: 614 HKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQM 673

Query: 503 RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWM--LEAQLAK----------IKLEKE 550
           ++L   +E +E L+ +V+   E+ +KL  EK+     LE  L++           +LEK+
Sbjct: 674 KVL---SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKK 730

Query: 551 NQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSE 610
            Q + ++  N          Q+    +   G  +     V E  +   ++  L    +S 
Sbjct: 731 LQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESL 790

Query: 611 VPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEE 670
               E + +L       +++EL  +++    +SV    +C  L   L   E+ K  L +E
Sbjct: 791 AKINEEKCNLAFQR-DEKVLELEKEIKCLQEESV---VQCEELKSLLRDYEQEKVLLRKE 846

Query: 671 MKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKK 730
           ++        LQ +L   K + E             N+ L  Q EE+      S+ +++K
Sbjct: 847 LEEIQSEKEALQSDLLEMKNANEKTR--------LENQNLLIQVEEVSQTCSKSEIHNEK 898

Query: 731 NK 732
            K
Sbjct: 899 EK 900



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 152/775 (19%), Positives = 281/775 (36%), Gaps = 153/775 (19%)

Query: 4    QSLRKLQQEMDSLTFRN----LQLAKRVELLQDELALSEPRGKKNKKSGESSSQLS---- 55
            +SL K+ +E  +L F+     L+L K ++ LQ+E  +     K   +  E    L     
Sbjct: 788  ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL 847

Query: 56   ---QEQKSVFDEDL-------QKKIEENERLHIQFFEADE-----------------QHK 88
               Q +K     DL       +K   EN+ L IQ  E  +                 +H+
Sbjct: 848  EEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHE 907

Query: 89   HVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECR 148
            +++  L  +   L    A+   + D L +      + L + K +LE K + LEKE KE  
Sbjct: 908  NLKPLLEQK--ELRDRRAELILLKDSLAKSPSVKNDPLSSVK-ELEEKIENLEKECKEKE 964

Query: 149  LRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRD 208
             +  + +L      ++L    +E+ ++  E       K  Q +A             MRD
Sbjct: 965  EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK-DQLSA------------SMRD 1011

Query: 209  IAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPL 268
            +   A ++       LL +   +EQ             +    ++ + + H      R L
Sbjct: 1012 LIQGAESYKN----LLLEYEKQSEQ-------------LDVEKERANNFEHRIEDLTRQL 1054

Query: 269  EEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCT 328
                L   E+I  D   +L    +++T   +         K+L  Q+  LE +   ++  
Sbjct: 1055 RNSTLQC-ETINSDNEDLL---ARIETLQSNA--------KLLEVQI--LEVQRAKAMVD 1100

Query: 329  SALRARNLELSQDMKKMTAVFEKLQTYIALLA-----LPSTEPDGLLRTNYSSVLTNVGA 383
              L A  L+  Q +K+      +L+     L      L  T  +  L    +   T +  
Sbjct: 1101 KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160

Query: 384  ALHGFHDVMKDISKHYSQK----AAIEHELPTATQKLITTNDCILSSVVALTNGAGKIAS 439
             +  +  +MK++++  + K      +E E+    QK  T  +              +I S
Sbjct: 1161 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQE--------------EITS 1206

Query: 440  FFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEAL 499
              S+                           + QY++K     + L K   E    ++A 
Sbjct: 1207 LQSS---------------------------VQQYEEKNTKIKQLLVKTKKELADSKQAE 1239

Query: 500  ANRRILLSSTESR-EGLAQQVQQSLEKISKLEQEK----EHWMLEAQLAKIKLEKENQRI 554
             +  IL +S +   E   QQV+    +++++  EK    EH    A+  +  L    QR+
Sbjct: 1240 TDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRV 1299

Query: 555  ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV 614
                +   +A+      E A V++     +     VL+  ++ S+    T  +  E   +
Sbjct: 1300 TALQEECRAAKA-----EQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHL 1354

Query: 615  ESREDLIK-------NHYMARIVEL-TSQLQLADSKSVHFYAECRALSKRLALAEKSKEA 666
            E   D +K       N+    + EL T Q +       H       +SK   L EK    
Sbjct: 1355 EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI 1414

Query: 667  LTEEMKLAS---QNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEID 718
             +E M + S   Q +S+L  +    + S+ DQ+  + +      ETL +Q  +++
Sbjct: 1415 QSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKME 1469



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 50/226 (22%), Positives = 105/226 (46%), Gaps = 23/226 (10%)

Query: 514 GLAQQVQQSLEKISKLEQEKEHWML--EAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQ 571
           G  +   ++L K   ++  K+  ML  +A+    +LEKE + +  K    G+  ++    
Sbjct: 16  GTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALT 75

Query: 572 E--NAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNH--YMA 627
           E  +A +   A  ++       E I+    +       DS     ++ ++L ++H  Y+ 
Sbjct: 76  ERLDALLLEKAETEQQCLSLKKENIKMKQEV------EDSVTKMGDAHKELEQSHINYVK 129

Query: 628 RIVELTSQLQLADSKSVHFYAECRA-LSKRLALAEKSKEALTEEMKL---ASQNISRLQD 683
            I  L ++L    SK    Y+E +A L K+L  A  ++  L+E++K    +  N+ +LQ+
Sbjct: 130 EIENLKNELMAVRSK----YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQE 185

Query: 684 ELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSK 729
           E+   +  +E+Q+  +   L   + T  +++E +  L+   + NS+
Sbjct: 186 EIEKIRPGFEEQILYLQKQL---DATTDEKKETVTQLQNIIEANSQ 228



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 147/800 (18%), Positives = 309/800 (38%), Gaps = 115/800 (14%)

Query: 6    LRKLQQEMDSLTFRNLQLAKRVELLQDEL-ALSEPRGKKNKKSGESSSQLSQEQKSVFDE 64
            + KL+ E+  L   N Q    VE    E+ +L E   K+  +  E+    S+++K     
Sbjct: 401  IEKLKSELAGL---NKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF 457

Query: 65   DLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIE 124
            ++Q   E+ E L  +  EA   ++     LR  +  L+TE  +    +   ++++    +
Sbjct: 458  EIQGLKEQCENLQQEKQEAILNYE----SLREIMEILQTELGESAGKI---SQEFESMKQ 510

Query: 125  KLQNDKAKLEVKSQTL--EKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPF 182
            +  +D  +L+ K +T   EK+A    +   + + +     ++L   LE ++  + EK   
Sbjct: 511  QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGV 570

Query: 183  NDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTA---LLNFHTYTEQRIQIF- 238
                 SQ + +   L       K+  +  +   F+  L  +   + NFH   E+  ++  
Sbjct: 571  YLLSLSQRDTMLKELEG-----KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLIL 625

Query: 239  ----PVDSAIDTISPLNQKFSQY-------LHENASYVRPLEEGMLHLF------ESITE 281
                 V+  I   S L QK ++        L E     + LE+ M+ +       E ++ 
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 282  DTVTVLETTVKLKTFSEHLTSYI-CFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ 340
            +  ++ E   KL +  + L+  +  FL +     LK    + E  L        NL    
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745

Query: 341  DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDV--------- 391
            + +++  +F K Q Y  L  + S   +     +  +VL  VG +L   ++          
Sbjct: 746  ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805

Query: 392  -----------------------MKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVV 428
                                   +K + + Y Q+  +   L    +++ +  + + S ++
Sbjct: 806  EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVL---LRKELEEIQSEKEALQSDLL 862

Query: 429  ALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKK--KAAAYMKSLR 486
             + N   K       N +  I         +   I     +C ++  +  K     K LR
Sbjct: 863  EMKNANEKTRL---ENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR 919

Query: 487  KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIK 546
                E +  +++LA    + +   S     +++++ +E + K  +EKE  + + +L  +K
Sbjct: 920  DRRAELILLKDSLAKSPSVKNDPLSS---VKELEEKIENLEKECKEKEEKINKIKLVAVK 976

Query: 547  LEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRT 606
             +KE   +    K T + +     +E  ++ +   Q  A+ + +++  +S   +  L   
Sbjct: 977  AKKE---LDSSRKETQTVK-----EELESLRSEKDQLSASMRDLIQGAESYKNL-LLEYE 1027

Query: 607  SDSEVPDVESREDLIKNHYMARIVELTSQL-------QLADSKSVHFYAECRALSKRLAL 659
              SE  DVE       N++  RI +LT QL       +  +S +    A    L     L
Sbjct: 1028 KQSEQLDVEKER---ANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKL 1084

Query: 660  AE-------KSKEALTEEMKLAS-QNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLS 711
             E       ++K  + +E++    Q   ++++  TT     E Q+ +  +      + L 
Sbjct: 1085 LEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKE-----KKQLQ 1139

Query: 712  KQREEIDTLKMSSKGNSKKN 731
            K  +E++ +K  ++  +  N
Sbjct: 1140 KTMQELELVKKDAQQTTLMN 1159


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.126    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,857,045
Number of Sequences: 37866
Number of extensions: 922681
Number of successful extensions: 6965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 586
Number of HSP's that attempted gapping in prelim test: 4684
Number of HSP's gapped (non-prelim): 2515
length of query: 734
length of database: 18,247,518
effective HSP length: 110
effective length of query: 624
effective length of database: 14,082,258
effective search space: 8787328992
effective search space used: 8787328992
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.