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Search of human proteins with 208431754
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208431754 KLRAQ motif containing 1 isoform 1 [Homo sapiens]
(780 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208431754 KLRAQ motif containing 1 isoform 1 [Homo sapiens] 1494 0.0
gi|24308420 KLRAQ motif containing 1 isoform 2 [Homo sapiens] 1465 0.0
gi|208431757 KLRAQ motif containing 1 isoform 3 [Homo sapiens] 1409 0.0
gi|71061468 centromere protein E [Homo sapiens] 79 1e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 73 9e-13
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 73 1e-12
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 72 2e-12
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 72 2e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 72 2e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 69 2e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 69 2e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 68 3e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 67 6e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 67 6e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 67 8e-11
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 66 1e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 66 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 1e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 65 2e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 65 2e-10
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 2e-10
gi|4506751 restin isoform a [Homo sapiens] 64 5e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 5e-10
gi|156104908 myosin heavy chain 6 [Homo sapiens] 63 1e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 2e-09
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 62 2e-09
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 62 2e-09
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 62 2e-09
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 62 2e-09
gi|38044112 restin isoform b [Homo sapiens] 62 2e-09
>gi|208431754 KLRAQ motif containing 1 isoform 1 [Homo sapiens]
Length = 780
Score = 1494 bits (3868), Expect = 0.0
Identities = 780/780 (100%), Positives = 780/780 (100%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD 60
MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD
Sbjct: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD 60
Query: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE
Sbjct: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
Query: 121 RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 180
RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE
Sbjct: 121 RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 180
Query: 181 VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN
Sbjct: 181 VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
Query: 241 VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF
Sbjct: 241 VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
Query: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 360
SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ
Sbjct: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 360
Query: 361 LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 420
LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY
Sbjct: 361 LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 420
Query: 421 SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 480
SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA
Sbjct: 421 SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 480
Query: 481 GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 540
GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP
Sbjct: 481 GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 540
Query: 541 YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI 600
YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI
Sbjct: 541 YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI 600
Query: 601 ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV 660
ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV
Sbjct: 601 ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV 660
Query: 661 ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA 720
ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA
Sbjct: 661 ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA 720
Query: 721 SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR
Sbjct: 721 SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
>gi|24308420 KLRAQ motif containing 1 isoform 2 [Homo sapiens]
Length = 769
Score = 1465 bits (3793), Expect = 0.0
Identities = 769/780 (98%), Positives = 769/780 (98%), Gaps = 11/780 (1%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD 60
MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD
Sbjct: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD 60
Query: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE
Sbjct: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
Query: 121 RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 180
RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE
Sbjct: 121 RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 180
Query: 181 VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN
Sbjct: 181 VKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
Query: 241 VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF
Sbjct: 241 VPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
Query: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 360
SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ
Sbjct: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 360
Query: 361 LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 420
LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY
Sbjct: 361 LKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNY 420
Query: 421 SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 480
SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA
Sbjct: 421 SSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGA 480
Query: 481 GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 540
GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP
Sbjct: 481 GKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 540
Query: 541 YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI 600
YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI
Sbjct: 541 YEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI 600
Query: 601 ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDV 660
ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL VPDV
Sbjct: 601 ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL-----------VPDV 649
Query: 661 ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA 720
ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA
Sbjct: 650 ESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLA 709
Query: 721 SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR
Sbjct: 710 SQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 769
>gi|208431757 KLRAQ motif containing 1 isoform 3 [Homo sapiens]
Length = 734
Score = 1409 bits (3648), Expect = 0.0
Identities = 734/734 (100%), Positives = 734/734 (100%)
Query: 47 MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 106
MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS
Sbjct: 1 MKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS 60
Query: 107 VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 166
VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM
Sbjct: 61 VFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 120
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV
Sbjct: 121 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 180
Query: 227 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 286
PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV
Sbjct: 181 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV 240
Query: 287 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 346
DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL
Sbjct: 241 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 300
Query: 347 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 406
TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA
Sbjct: 301 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 360
Query: 407 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 466
LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN
Sbjct: 361 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 420
Query: 467 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 526
DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA
Sbjct: 421 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA 480
Query: 527 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 586
YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA
Sbjct: 481 YMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEA 540
Query: 587 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 646
QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI
Sbjct: 541 QLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLI 600
Query: 647 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 706
GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA
Sbjct: 601 GTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA 660
Query: 707 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 766
EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL
Sbjct: 661 EKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 720
Query: 767 KMSSKGNSKKNKSR 780
KMSSKGNSKKNKSR
Sbjct: 721 KMSSKGNSKKNKSR 734
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 79.3 bits (194), Expect = 1e-14
Identities = 166/803 (20%), Positives = 328/803 (40%), Gaps = 148/803 (18%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVV------DEQANSAALKEQLKMKDQSLRK 54
+ + EL+GK L +E +K +N+ L++ V+ + L+++++ K + L
Sbjct: 713 LCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHI 772
Query: 55 LQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSV---FDED 111
+ E D L + RV+ L +E+ ++ + + +S+ Q Q K++ F++
Sbjct: 773 ITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832
Query: 112 LQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 171
+ +EENER++ + ++ + + S L L+TE + + TR+ E + +
Sbjct: 833 YKMVLEENERMNQEIVNLSKEAQKFD----SSLGALKTELSYKTQELQEKTREVQERLNE 888
Query: 172 LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDT 231
++ K +LE + TL+ +E L TE+ L LEE ++ EK +D
Sbjct: 889 MEQLKEQLENRDSTLQTVEREKTLITEK-----------LQQTLEEVKTLTQEK---DDL 934
Query: 232 KYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID 291
K Q + L R QLK + + D V +N T + R + + +
Sbjct: 935 KQLQES-----LQIERDQLK---------SDIHDTVN--MNIDTQEQLRNALESLKQHQE 978
Query: 292 TISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC 351
TI+ L K S+ + N +EE + + V + + ++ LT+ +
Sbjct: 979 TINTLKSKISEEVSRNLH----MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK 1034
Query: 352 FLRKILPYQLK---SLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALP 408
+I+ Q K ++E+ E ++ A +L D+K+ + + Q + LL
Sbjct: 1035 D-NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE 1093
Query: 409 STEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDC 468
+ ++ + + G ++S+ + A +E +L +Q+L
Sbjct: 1094 LKKQQEIVAQEKNHAIKKEG-----------ELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
Query: 469 ILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYM 528
+L+ ++ KI I L E L+ K+ +M
Sbjct: 1143 LLNVQEEMSEMQKKINE-----------------------IENLKNE--LKNKELTLEHM 1177
Query: 529 KSLRKPLLESV--PYEEALA---NRRILLSSTESREGLAQQVQQSLEKISKLE-QEKEHW 582
++ R L + + YEE + R++L +S E ++ + +I Q KE
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE-- 1235
Query: 583 MLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQS 642
E ++A I L KE+Q D+L+ + ++++ A + NT +++ K
Sbjct: 1236 --ELKIAHIHL-KEHQETIDELRRS-------VSEKTAQIINTQDLEKSHTKL------- 1278
Query: 643 TSLIGTLTRTSDSEVPDVESREDLIKN--------HYMARIVELTSQLQLADSKSVHFYA 694
E+P + ++L+ N M + LT Q DS ++
Sbjct: 1279 -----------QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTL---- 1323
Query: 695 ECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNE 754
R +RL L EK +E+ EE+K ++++ +D L T K + E + + +H+ E
Sbjct: 1324 -ARIEMERLRLNEKFQES-QEEIK----SLTKERDNLKTIKEALEVKHDQLKEHI---RE 1374
Query: 755 TLSK----QREEIDTLKMSSKGN 773
TL+K Q ++ +L M K N
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDN 1397
Score = 63.5 bits (153), Expect = 7e-10
Identities = 111/468 (23%), Positives = 196/468 (41%), Gaps = 66/468 (14%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
A++Q K Q + N+ K +V E EQ K KD +L +++ EM
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTK--IVSEM-------EQFKPKDSALLRIEIEM---- 1423
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLH 123
L L+KR++ DE+ ++ E S + K E + K +E E L
Sbjct: 1424 ---LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480
Query: 124 IQFFEADEQHKHVEAELRSRLATLETEAA----QHQAVVDGLTRKYMETIEKLQ--NDKA 177
+ EQ + + ELR L+ ETE + Q +A+ D L K E EK + N K
Sbjct: 1481 VAHCCLKEQEETIN-ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQ 1539
Query: 178 KLEVKSQTLE-KEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQY 236
EV+ + E K+ KE R + +++ +L+ RL+ES E++ + +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES----QEEIQIMIKEKEEM 1595
Query: 237 NALNVPLHNRRHQLK--MRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSA----- 289
+ L R QLK ++I + + Q+ L E + ++ ++
Sbjct: 1596 KRVQEALQIERDQLKENTKEIVAK-MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 290 -----IDTISPLNQKFSQYLHENASY----------VRPLEEGML----HLFESITEDTV 330
++ I N + +Q LHEN +R +EE + L E++ E
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714
Query: 331 TVLETTVKLKTFSEHLTSY---ICFLRKIL---PYQLKSLEEECESSLCTSALRARNLEL 384
LE +LK HL + I LR I+ ++ +++++ E S AL+A++L++
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS--NDALKAQDLKI 1772
Query: 385 SQDMK-KMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAAL 431
++++ + E+ +T L + S + D L +N L N A L
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKL--SNMQKDLENSNAKL 1818
Score = 60.8 bits (146), Expect = 5e-09
Identities = 88/406 (21%), Positives = 175/406 (43%), Gaps = 59/406 (14%)
Query: 11 QKLAQEYSKLRAQNQVLKK--GVVDEQANSAA-LKEQLKMKDQSLRKLQQEMDSLTFRNL 67
++L + L+ Q + + K G+V E+ + + +++ L+ + L++ QE+ + + +
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 68 QLAKRVELLQDELALSEPRGKKNKKSGESSSQLS--------------QEQKSVFDE-DL 112
L K V Q +++ E K+ K + S+L +E KSV E D
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 113 QKKIEENERLHI-QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 171
+++EE +L Q E+ ++ K + E++ L T + +H+ VD L K E +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 172 LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDT 231
+ + + L+ L+K+ +E L+ +E QL R++E +++ ++K+ +
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQE--LQKKELQLL----------RVKEDVNMSHKKINEMEQ 2001
Query: 232 KYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPV----- 286
Q+ A N L M+ + + L +L ++R ++ +
Sbjct: 2002 LKKQFEAQN---------LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
Query: 287 ---DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFS 343
D I T+ + + Q H+ R L +G HL ES+ E + E LK +S
Sbjct: 2053 MERDQFIATLREMIARDRQN-HQVKPEKRLLSDGQQHLTESLREKCSRIKEL---LKRYS 2108
Query: 344 EHLTSYICF------LRKILPYQLKSLEEECESSLCTSALRARNLE 383
E Y C L K + +Q K L +++L L+ +++E
Sbjct: 2109 EMDDHYECLNRLSLDLEKEIEFQ-KELSMRVKANLSLPYLQTKHIE 2153
Score = 55.1 bits (131), Expect = 2e-07
Identities = 177/816 (21%), Positives = 326/816 (39%), Gaps = 134/816 (16%)
Query: 9 KYQKLAQEYSKLRAQNQVLKKGVVDE-QANSAALKEQLKMKDQSLRKLQQEMDSLT---- 63
K +K+ +E K + +G + E +A KE+LK+ L++ Q+ +D L
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 64 ------FRNLQLAKRVELLQDELALSE------PRGKKNKKSGESSSQLS--QEQKSVFD 109
L K LQ+E+ + P K+ ++ E+ ++L EQ + D
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 110 EDLQKKIE-ENERLHIQFFEADEQHKHVEAELRSRLATL-ETEAAQHQAVVDGLTRKYME 167
+IE E RL+ +F E+ E+ K + E R L T+ E +H D L E
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKE-RDNLKTIKEALEVKH----DQLKEHIRE 1374
Query: 168 TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQ--------LQLKTLHEDLSGRLEESL 219
T+ K+Q ++K E EK+ + ++ +E Q L+++ LS RL+ES
Sbjct: 1375 TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES- 1433
Query: 220 SIINEKVPFNDTKYSQYNALNVPLHNRRHQLK--MRDIAGQALAFVQDLVTALL----NF 273
++++ + L L + QLK +++I + L ++L A
Sbjct: 1434 ---HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 274 HTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 333
T E R+ + ++ I TI + + L + EE + I+E V
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQF--NIKQISE----VQ 1544
Query: 334 ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTA 393
E +LK F EH RK L+S+E + L R E ++++ M
Sbjct: 1545 EKVNELKQFKEH--------RKAKDSALQSIESK------MLELTNRLQESQEEIQIMIK 1590
Query: 394 VFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQK--AAI 451
E+++ L + + L+ N ++ + + + +K + + +Q+ I
Sbjct: 1591 EKEEMKRVQEALQIERDQ----LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI 1646
Query: 452 EH-ELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFIS 510
EH + TQKL N I + + LT NL+ +
Sbjct: 1647 EHLKEQFETQKLNLEN--IETENIRLT-------QILHENLEEMRSVTKERDDLR----- 1692
Query: 511 PLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRI-LLSSTESREGLAQQVQQSL 569
S E L+ ++ ++LR+ + + +E L + L E+ + L V +
Sbjct: 1693 --SVEETLKVERD--QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKT 1748
Query: 570 EKISKLEQEKEHW--MLEAQLAKIKLE--------KENQRIADKLKNTGSAQLVGLAQEN 619
+IS ++++ EH L+AQ KI+ E KE Q DKL+ S + L+
Sbjct: 1749 NEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQ 1808
Query: 620 AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 679
+ N+ + + + + + + +V ++E + IK+ +
Sbjct: 1809 KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT-----L 1863
Query: 680 SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 739
S+L++ + L LA+K E L EEMK ++ + +D L R E
Sbjct: 1864 SKLEI----------------ENLNLAQKLHENL-EEMK----SVMKERDNL----RRVE 1898
Query: 740 DQLSMMSDHLC-SMNETLSKQ---REEIDTLKMSSK 771
+ L + D L S+ ET ++ ++E+ T +M SK
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSK 1934
Score = 52.8 bits (125), Expect = 1e-06
Identities = 139/750 (18%), Positives = 294/750 (39%), Gaps = 102/750 (13%)
Query: 43 EQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQ 102
E L+ K+ ++KLQ+ +DS N+ +++L ++ +P+ K + L
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENI----KMDLSYSLESIEDPKQMKQTLFDAETVALDA 637
Query: 103 EQKSVF----DEDLQKKIEENERLH------IQFFEAD-EQHKHVEAELRSRLATLETEA 151
+++S F + +L++K++E + IQ +++ E K ++ +L L + E
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 152 AQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQL--------- 202
+ +++DG K + +L+ K+ + L KE +E EE L
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELE---GKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 203 QLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAF 262
+++ L +++ + EE I +EK D +S+ +H + + G+
Sbjct: 755 EVERLRKEIQDKSEELHIITSEK----DKLFSEV------VHKESRVQGLLEEIGKT--- 801
Query: 263 VQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLF 322
DL T N+ + T+Q Q F QK+ L EN
Sbjct: 802 KDDLATTQSNYKS-TDQEFQNFKT-----LHMDFEQKYKMVLEEN--------------- 840
Query: 323 ESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC-ESSLCTSALRARN 381
E + ++ V + + K + L + + + + L + + ++E E L R+
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 382 LELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDI 441
L ++ T + EKLQ + + + E D L + S + + DI
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER--------DQLKSDI 952
Query: 442 SKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYG 501
+ + +L A + L + I KI+ S NL
Sbjct: 953 HDTVNMNIDTQEQLRNALESLKQHQETI-------NTLKSKISEEVSRNLHM-------- 997
Query: 502 PKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGL 561
+ +G + M+ KK K+ + L V E + +R + S + + L
Sbjct: 998 -EENTGETKDEFQQKMVGIDKKQDLEAKN-TQTLTADVKDNEIIEQQRKIFSLIQEKNEL 1055
Query: 562 AQQVQQSLEKISKLEQE-KEHWML------EAQLAKIKLEKENQRIADKLKNTGSAQLVG 614
Q ++ + + +L+ + KE+ + E +L +L+K+ + +A + KN +
Sbjct: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE-KNHAIKKEGE 1114
Query: 615 LAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMAR 674
L++ ++ + + ++ + E Q + ++ ++E+ ++ +KN +
Sbjct: 1115 LSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174
Query: 675 IVELTSQLQLADSKSVHFYAECRALSK-RLALAEKSKEALTEEMKLASQNISRLQDELTT 733
T +L+LA + + Y E ++++K R L E K TE ++ E+
Sbjct: 1175 EHMETERLELAQKLNEN-YEEVKSITKERKVLKELQKSFETER-----DHLRGYIREIEA 1228
Query: 734 TKRSYEDQLSMMSDHLCSMNETLSKQREEI 763
T +++L + HL ET+ + R +
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSV 1258
Score = 45.1 bits (105), Expect = 3e-04
Identities = 147/777 (18%), Positives = 292/777 (37%), Gaps = 129/777 (16%)
Query: 46 KMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQK 105
KMK+ + ++T + +L+ + DE SE N S + + K
Sbjct: 430 KMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATK 489
Query: 106 SVFDEDLQKKIE----ENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL 161
+ E+++ ++ + + L + + + + + +E +L+ + E EA + + D
Sbjct: 490 LLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ- 548
Query: 162 TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG------RL 215
+ + I L+N EV +Q LE E E + Q+K L E + ++
Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608
Query: 216 EESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHT 275
+ S S+ + + P K + ++A V L +R +R + +++L T T
Sbjct: 609 DLSYSLESIEDP-KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT------T 661
Query: 276 YTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLET 335
Y + I Q + L LE+ + F IT+ T +
Sbjct: 662 YKQMENDI--------------QLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK 707
Query: 336 TVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVF 395
K + L I L+K L +++ E E + S L++ E+ + K++
Sbjct: 708 VPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKS 767
Query: 396 EKLQTYIALLALPSTEPDGLL------RTNYSSVLTNVGAA---LHGFHDVMKDISKHYS 446
E+L + ++E D L + +L +G L K + +
Sbjct: 768 EELH-------IITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ 820
Query: 447 QKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAAS 506
+ + + ++ N+ + +V L+ A K F ++L LSY +
Sbjct: 821 NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK----FDSSLGALKTELSYKTQE-- 874
Query: 507 GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGL-AQQV 565
LQ K + +++ L E +E L NR L + E + L +++
Sbjct: 875 -----------LQEK------TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL 917
Query: 566 QQSLEKISKLEQEK-------EHWMLEAQLAK----------IKLEKENQRIADKLK--- 605
QQ+LE++ L QEK E +E K I +++ + + LK
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ 977
Query: 606 ---NTGSAQLVGLAQENAAVSNTAGQ--DEATAKAV-LEPIQSTSLIGTLTRTSDSEVPD 659
NT +++ N + G+ DE K V ++ Q T T T+ D
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA-----D 1032
Query: 660 VESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKL 719
V+ E + + + +++ ++LQ + L +A E+ K L E +++
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQ-------------QMLESVIAEKEQLKTDLKENIEM 1079
Query: 720 ASQNISRL---------QDELTTTKRSY----EDQLSMMSDHLCSMNETLSKQREEI 763
+N L Q E+ ++++ E +LS D L + E L ++ +++
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Score = 38.1 bits (87), Expect = 0.032
Identities = 65/292 (22%), Positives = 111/292 (38%), Gaps = 31/292 (10%)
Query: 511 PLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESR----EGLAQQVQ 566
P C L+ + K K L K + E+ EAL ILLS +S E L +++Q
Sbjct: 709 PKDLLCNLELEGKITDLQKELNKEVEEN----EALREEVILLSELKSLPSEVERLRKEIQ 764
Query: 567 QSLEKISKLEQEKEHWMLEAQLAKIKLE---KENQRIADKLKNTGSAQLVGLAQENAAVS 623
E++ + EK+ E + +++ +E + D L T S QE
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS-NYKSTDQEFQNFK 823
Query: 624 NTAGQDEATAKAVLEPIQST---------------SLIGTLTRTSDSEVPDVESREDLIK 668
E K VLE + S +G L + +++ + ++
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883
Query: 669 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 728
+ + +L QL+ DS E ++++L + + LT+E Q LQ
Sbjct: 884 ER-LNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 729 DELTTTKRSYEDQLSMMSD---HLCSMNETLSKQREEIDTLKMSSKGNSKKN 777
E K D ++M D L + E+L + +E I+TLK +N
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Score = 31.6 bits (70), Expect = 3.0
Identities = 50/229 (21%), Positives = 91/229 (39%), Gaps = 46/229 (20%)
Query: 15 QEYSKLRAQNQVLKKGVVDE-----QANS-------AALKEQLKMKDQSL---RKLQQEM 59
+E+ R + LK G+ E Q N+ A + E + +++S ++ +Q++
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDL 2332
Query: 60 DSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKS--VFDEDLQKKIE 117
SL +N +L K + L+ LA SG + +Q+ K+ V Q E
Sbjct: 2333 KSLKEKNEKLFKNYQTLKTSLA-----------SGAQVNPTTQDNKNPHVTSRATQLTTE 2381
Query: 118 ENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKA 177
+ L EA E H E+++ LE + I KLQ A
Sbjct: 2382 KIRELENSLHEAKESAMHKESKIIKMQKELEVTN---------------DIIAKLQ---A 2423
Query: 178 KLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
K+ ++ LEK + ++ ++ L K E++ + + I EK+
Sbjct: 2424 KVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 73.2 bits (178), Expect = 9e-13
Identities = 155/777 (19%), Positives = 303/777 (38%), Gaps = 70/777 (9%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ +D + + L E+LK K+ + LQ +++ +QL K+++ LQ
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + ++ +S +++Q+S +L++ E E E +K EA
Sbjct: 1118 RIEELE----EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K+ +++ +L L+ Q LEKE E ++ +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+ ++T+ + G LE+ + +++ TK + L L +R +L+
Sbjct: 1234 DLASNMETVSK-AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYS 1292
Query: 259 ALAFVQDLVTALLN--FHTYTEQRIQI-FPVDSAIDTISPLNQKFSQYLHE---NASYVR 312
+D + + L+ +T+Q ++ ++ I S L H+
Sbjct: 1293 RQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE 1352
Query: 313 PLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSL 372
+E L ++++ V + K +T + T + +K L +L+ EE E
Sbjct: 1353 EEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE--- 1409
Query: 373 CTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALH 432
A+ A+ L + +++ E L + RTN + AAL
Sbjct: 1410 ---AVNAKCASLEKTKQRLQNEVEDLMIDVE-------------RTNAAC------AALD 1447
Query: 433 GFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLD 492
I + QK H A+QK +L+ KI + + +LD
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQK----------ESRSLSTELFKIKNAYEESLD 1497
Query: 493 YFIASLSYGPKAASGFISPLSAECM--------LQYKKKAAAYMKSLRKPLLESVPYEEA 544
+ +L K IS L+ + L+ KK KS + LE
Sbjct: 1498 Q-LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 1556
Query: 545 LANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKE----NQRI 600
+IL E + ++ ++ EK +++Q K + + + + L+ E N I
Sbjct: 1557 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616
Query: 601 ADKLKNTGSAQLVGLAQENA-AVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSD--SEV 657
K K G + + +A ++ A ++ +A+L+ Q L L D ++
Sbjct: 1617 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ-LHLDDALRSQEDLKEQL 1675
Query: 658 PDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEM 717
VE R +L++ A I EL + L+ + E S+R+ L +L
Sbjct: 1676 AMVERRANLLQ----AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 718 KLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 771
K +IS++Q +++ R+ E++ M E L K+++ L+ K
Sbjct: 1732 KKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Score = 70.5 bits (171), Expect = 6e-12
Identities = 158/790 (20%), Positives = 324/790 (41%), Gaps = 82/790 (10%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 937 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
Query: 63 TFRNLQLAKRVELLQD--ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
+L K + LQ+ + L + + +++K + + +++ EQ+ +DL+ +E+ +
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEK 1046
Query: 121 RLHIQFFE-----------ADEQHKHVE---AELRSRLATLETEAAQHQAVVDGLTRKYM 166
++ + A E +E +L +L E E + Q+ ++ M
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+ +K++ +A++E + +E E + R + E+ + L E++S RLEE+ + ++
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAE-RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 227 PFNDTKYSQYNALNVPLHNR--RHQLKMRDIAGQALAFVQDLVTALLNFHTY-------- 276
N + +++ + L +H+ + + V +L + N
Sbjct: 1166 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1225
Query: 277 TEQRIQIFPVDSAIDTISPLN---QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV- 332
+E +++I + S ++T+S +K + L + S ++ EE L +T +
Sbjct: 1226 SEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ 1285
Query: 333 LETTVKLKTFSEH--LTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ-DMK 389
E+ + E L S + ++ Q++ L+ + E + + A L+ S+ D
Sbjct: 1286 TESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCD 1345
Query: 390 KMTAVFEKLQTYIALLALPSTEPDGLL---RTNYSS----VLTNVGAALHGFHDVMKDIS 442
+ +E+ Q A L ++ + + RT Y + + A ++D
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 443 KHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGP 502
+H A L Q+L + ++ V TN A N D +A
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMID-VERTNAACAALDKKQRNFDKILAEWKQKC 1464
Query: 503 KAASGFISPLSAE---CMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 559
+ + E + K AY +SL + LE++ E + I + + E
Sbjct: 1465 EETHAELEASQKESRSLSTELFKIKNAYEESLDQ--LETLKRENKNLQQEISDLTEQIAE 1522
Query: 560 GLAQQVQQSLEKISK-LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQE 618
G +++ + LEKI K +EQEK + A+ LE E +I QL +
Sbjct: 1523 G-GKRIHE-LEKIKKQVEQEKSELQAALEEAEASLEHEEGKIL-------RIQLELNQVK 1573
Query: 619 NAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLI--KNHYMARIV 676
+ A +DE + I+ ++ ++ T D+E + SR D I K +
Sbjct: 1574 SEVDRKIAEKDEEIDQMKRNHIR---IVESMQSTLDAE---IRSRNDAIRLKKKMEGDLN 1627
Query: 677 ELTSQLQLAD---SKSVHFYAECRALSKRLAL----AEKSKEALTEEMKLASQNISRLQD 729
E+ QL A+ ++++ Y +A+ K L A +S+E L E++ + + + LQ
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 730 ELTTTKRSYE 739
E+ + + E
Sbjct: 1688 EIEELRATLE 1697
Score = 40.4 bits (93), Expect = 0.006
Identities = 51/244 (20%), Positives = 92/244 (37%), Gaps = 21/244 (8%)
Query: 533 KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSL-EKISKLEQEKEHWMLEAQLAKI 591
KPLL+S E+ +AN + T+ + ++ L EK+ L QEK L+ Q
Sbjct: 841 KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 592 KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTR 651
L +R +K T Q EA K V E + I
Sbjct: 901 SLADAEERCDQLIK-------------------TKIQLEAKIKEVTERAEDEEEINAELT 941
Query: 652 TSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKE 711
++ D S + + ++ + ++K + E L + +A K K+
Sbjct: 942 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
Query: 712 ALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 771
AL E + ++ +D++ T ++ + +L D L E K R +++ K +
Sbjct: 1002 ALQEAHQQTLDDLQAEEDKVNTLTKA-KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Query: 772 GNSK 775
G+ K
Sbjct: 1061 GDLK 1064
Score = 35.8 bits (81), Expect = 0.16
Identities = 74/339 (21%), Positives = 133/339 (39%), Gaps = 41/339 (12%)
Query: 43 EQLKMKDQSLRKLQQEMDSLTFRNLQLAKRV-ELLQDELALSEPRGKKNKKSGESSSQLS 101
+QL+ + + LQQE+ LT + + KR+ EL + + + + + + E+ + L
Sbjct: 1497 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLE 1556
Query: 102 QEQKSVFDEDL---QKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVV 158
E+ + L Q K E + ++ + E D+ ++ + S +TL+ E
Sbjct: 1557 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRN--- 1613
Query: 159 DGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLK--TLHEDLSGRLE 216
D + K +K++ D ++E++ + A E Q LK LH D + R +
Sbjct: 1614 DAIRLK-----KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ 1668
Query: 217 ESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQL----KMRDIAGQALAFVQDLVTALLN 272
E L E++ + + N L + R L + R IA Q L + V L
Sbjct: 1669 EDL---KEQLAMVERR---ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL-- 1720
Query: 273 FHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV 332
HT S I+T L SQ E ++ ++IT D +
Sbjct: 1721 -HTQN---------TSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAIT-DAAMM 1769
Query: 333 LETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESS 371
E K + S HL ++K L +K L+ + +
Sbjct: 1770 AEELKKEQDTSAHLER----MKKNLEQTVKDLQHRLDEA 1804
Score = 31.6 bits (70), Expect = 3.0
Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 8/106 (7%)
Query: 15 QEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVE 74
++ KL A+ + L+ V EQ + E +K LRK ++++ LT++ + K +
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNV---EAVK----GLRKHERKVKELTYQTEEDRKNIL 1866
Query: 75 LLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
LQD + + + K K+ E + + S S F +Q ++EE E
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKF-RRIQHELEEAE 1911
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 72.8 bits (177), Expect = 1e-12
Identities = 159/797 (19%), Positives = 305/797 (38%), Gaps = 110/797 (13%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ ++D + + L E+LK KD L L ++ QL K+++ LQ
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQA 1113
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + + + +L + +E ++ E +Q E +K EA
Sbjct: 1114 RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI----EMNKKREA 1169
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K+ +++ +L L+ Q LEKE E +L
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL- 1228
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+D++ +E+ II K + + +N + R A +
Sbjct: 1229 ----------DDVTSNMEQ---IIKAKANLEKMCRTLEDQMN----------EHRSKAEE 1265
Query: 259 ALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGM 318
V DL T QR + + N + S+ L E + + L G
Sbjct: 1266 TQRSVNDL----------TSQRAK----------LQTENGELSRQLDEKEALISQLTRGK 1305
Query: 319 LHLFESITEDTVTVLETTVKLKTFSEHL---TSYICFLRKILPYQLKSLEEECESSL-CT 374
L + + ED LE VK K H + C L + + EEE E+
Sbjct: 1306 LTYTQQL-EDLKRQLEEEVKAKNALAHALQSARHDCDLLR------EQYEEETEAKAELQ 1358
Query: 375 SALRARNLELSQ-------DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNV 427
L N E++Q D + T E+ + +A + E + SS+
Sbjct: 1359 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTK 1418
Query: 428 GAALHGFHDVMKDISKHYSQKAAIEHE-------LPTATQKLITTNDCILSS---VVALT 477
+ D+M D+ + + AA++ + L QK + + SS +L+
Sbjct: 1419 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1478
Query: 478 NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC---------MLQYKKKAAAYM 528
K+ + + +L++ + + K IS L+ + + + +K+ A
Sbjct: 1479 TELFKLKNAYEESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEK 1537
Query: 529 KSLRKPLLE---SVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLE 585
L+ L E S+ +EE +IL + E + A+ ++ EK ++EQ K + +
Sbjct: 1538 MELQSALEEAEASLEHEEG----KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593
Query: 586 AQLAKIKLEKE----NQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQ 641
+ L+ E N+ + K K G + + +A + A + + K++ ++
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA--NRMAAEAQKQVKSLQSLLK 1651
Query: 642 STSL-IGTLTRTSD---SEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECR 697
T + + R +D + VE R +L++ A + EL + ++ + E
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQ----AELEELRAVVEQTERSRKLAEQELI 1707
Query: 698 ALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMNE 754
S+R+ L +L + K ++S+LQ +E R+ E++ M E
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAE 1767
Query: 755 TLSKQREEIDTLKMSSK 771
L K+++ L+ K
Sbjct: 1768 ELKKEQDTSAHLERMKK 1784
Score = 58.9 bits (141), Expect = 2e-08
Identities = 146/762 (19%), Positives = 292/762 (38%), Gaps = 126/762 (16%)
Query: 41 LKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQL 100
LKE L+ + ++L+++M SL L +V+ QD LA +E E QL
Sbjct: 859 LKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAE----------ERCDQL 908
Query: 101 SQEQKSVFDEDLQKKIEE-NERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVD 159
+ + L+ K++E NERL E + + AEL ++ LE E ++ + +D
Sbjct: 909 IKNK-----IQLEAKVKEMNERL--------EDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 160 GLTRKYMETIEKLQNDKAKLEVKSQTLEKE-----------AKECRLRTEECQLQLKTL- 207
L T+ K++ +K E K + L +E KE + E Q L L
Sbjct: 956 DLEL----TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011
Query: 208 -HEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDL 266
ED L ++ + ++V + Q + + L + +L+ L Q+
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE------GDLKLTQES 1065
Query: 267 VTALLNFHTYTEQRI-----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHL 321
+ L N ++R+ ++ +++ I+ L + + L E + + LEE +
Sbjct: 1066 IMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEEL--- 1122
Query: 322 FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARN 381
E T + K LR L +L+ + E E + ++++
Sbjct: 1123 ----------EAERTARAKVEK---------LRSDLSRELEEISERLEEAGGATSVQ--- 1160
Query: 382 LELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDI 441
+E++ KK A F+K++ + L LR ++ + +G + V + +
Sbjct: 1161 IEMN---KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1217
Query: 442 SKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYG 501
K +K+ + EL T + ++ K+ + ++ +
Sbjct: 1218 EK---EKSEFKLELDDVTSN--------MEQIIKAKANLEKMCRTLEDQMNEHRSKAEET 1266
Query: 502 PKAASGFISPL------SAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSST 555
++ + S + E Q +K A + R L + E+ +R L
Sbjct: 1267 QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL---KRQLEEEV 1323
Query: 556 ESREGLAQQVQQSLEKISKL-EQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVG 614
+++ LA +Q + L EQ +E +A+L ++ L K N +A
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV-LSKANSEVAQWRTK-------- 1374
Query: 615 LAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMAR 674
E A+ T +EA K ++ + + +++ +E + ++N
Sbjct: 1375 --YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV----NAKCSSLEKTKHRLQN----E 1424
Query: 675 IVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTT 734
I +L ++ +++ + + R K LA ++ E E++ + + L EL
Sbjct: 1425 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 735 KRSYEDQLSMMSDHLCSMNETLSKQREEIDTL--KMSSKGNS 774
K +YE+ L +HL + +EEI L ++ S G +
Sbjct: 1485 KNAYEESL----EHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Score = 54.3 bits (129), Expect = 4e-07
Identities = 167/821 (20%), Positives = 330/821 (40%), Gaps = 111/821 (13%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
+K E+ K+R L++ + +A +AAL+ K S+ +L +++D+L +L
Sbjct: 1165 KKREAEFQKMRRD---LEEATLQHEATAAALR---KKHADSVAELGEQIDNLQRVKQKLE 1218
Query: 71 KR---VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 127
K +L D++ + + K K + E + ++Q + + + K EE +R
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN----EHRSKAEETQR------ 1268
Query: 128 EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLE 187
+ A+L++ L + + +A++ LTR + ++L++ K +LE + +
Sbjct: 1269 -SVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327
Query: 188 KEAKECRLRTEECQLQLKTLHEDLSGR--LEESLSIINEKVPFNDTKYSQYNALNVPLHN 245
A + +C L + E+ + L+ LS N +V TKY + +A+
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY-ETDAIQRTEEL 1386
Query: 246 RRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID------TISPLNQK 299
+ K+ +A V + V A + T+ R+Q D +D + L++K
Sbjct: 1387 EEAKKKLAQRLQEAEEAV-EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Query: 300 FSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK-TFSEHLTSYICFLR--KI 356
+ A + + EE L ES ++ ++ KLK + E L F R K
Sbjct: 1446 QRNFDKILAEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504
Query: 357 LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL 416
L ++ L E+ SS T EL + K++ A EK++ AL E + L
Sbjct: 1505 LQEEISDLTEQLGSSGKTIH------ELEKVRKQLEA--EKMELQSAL-----EEAEASL 1551
Query: 417 RTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVAL 476
+L A F+ + +I + ++K + E+ A + + D + +S+ A
Sbjct: 1552 EHEEGKIL----RAQLEFNQIKAEIERKLAEK---DEEMEQAKRNHLRVVDSLQTSLDAE 1604
Query: 477 T---NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK 533
T N A ++ +L+ LS+ + ++AE Q K + +K +
Sbjct: 1605 TRSRNEALRVKKKMEGDLNEMEIQLSHANR--------MAAEAQKQV-KSLQSLLKDTQI 1655
Query: 534 PLLESVPYEEALANRRILLSSTESREGLAQ----QVQQSLEKISKLEQEKEHWMLEAQLA 589
L ++V + L ++ E R L Q +++ +E+ + + E ++E
Sbjct: 1656 QLDDAVRANDDLKEN---IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 590 KIKLEKENQRIADKLKNTGSAQLVGLAQE-NAAVSNTAGQDEATAKAV---------LEP 639
L +N + ++ K A L L E AV +E KA+ L+
Sbjct: 1713 VQLLHSQNTSLINQKKKM-DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK 1771
Query: 640 IQSTSL-IGTLTRTSDSEVPDVESREDLIKNHYM-----------ARIVELTSQLQLADS 687
Q TS + + + + + D++ R D + + AR+ EL ++L+
Sbjct: 1772 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK 1831
Query: 688 KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRSYEDQLSM 744
++ R +R+ + LT + + +N+ RLQ D+L ++Y+ Q
Sbjct: 1832 RNAESVKGMRKSERRI-------KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEE 1884
Query: 745 MSDHLCSMNETLSKQREEIDTLK-----MSSKGNSKKNKSR 780
+ + K + E+D + S+ N + KSR
Sbjct: 1885 AEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
Score = 38.9 bits (89), Expect = 0.019
Identities = 54/247 (21%), Positives = 102/247 (41%), Gaps = 27/247 (10%)
Query: 533 KPLLESVPYEEALANRRI----LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQL 588
KPLL+S E+ +A+ + L + E E ++++ EK+ L QEK L+ Q
Sbjct: 837 KPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELE---EKMVSLLQEKNDLQLQVQA 893
Query: 589 AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGT 648
+ L +R +KN QL +E N +DE A L
Sbjct: 894 EQDNLADAEERCDQLIKN--KIQLEAKVKE----MNERLEDEEEMNAELT---------A 938
Query: 649 LTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEK 708
R + E +++ D ++ + ++ + ++K + E L + +A K
Sbjct: 939 KKRKLEDECSELKRDIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK 994
Query: 709 SKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKM 768
K+AL E + A ++ +D++ T ++ + +L D L E K R +++ K
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNTLTKA-KVKLEQQVDDLEGSLEQEKKVRMDLERAKR 1053
Query: 769 SSKGNSK 775
+G+ K
Sbjct: 1054 KLEGDLK 1060
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 72.4 bits (176), Expect = 2e-12
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 117/768 (15%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ ++D + L E+LK K+ + LQ +++ +QL K+++ LQ
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + ++ +S +++Q+S +L++ E E E +K EA
Sbjct: 1120 RIEELE----EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K+ +++ +L L+ Q LEKE E ++ +
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+ ++T+ + G LE+ + +++ +LK ++ Q
Sbjct: 1236 DLASNVETVSK-AKGNLEKMCRTLEDQL---------------------SELKSKEEEQQ 1273
Query: 259 ALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGM 318
L + DL T QR + + +FS+ L E + V L G
Sbjct: 1274 RL--INDL----------TAQR----------GRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 319 LHLFESITEDTVTVLETTVKLKTFSEHL---TSYICFLRKILPYQLKSLEEECESSL-CT 374
F E+ LE +K K H + + C L + + EEE ES
Sbjct: 1312 -QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR------EQYEEEQESKAELQ 1364
Query: 375 SALRARNLELSQ-------DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNV 427
AL N E++Q D + T E+ + +A + E + +S+
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 428 GAALHGFHDVMKDISKHYSQKAAIEHE-------LPTATQKLITTN---DCILSSVVALT 477
+ D+M D+ + + AA++ + L QK T+ + +L
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 478 NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLE 537
KI + + +LD + +L K IS L+ E + + K+ K ++ E
Sbjct: 1485 TELFKIKNAYEESLDQ-LETLKRENKNLQQEISDLT-EQIAEGGKRIHELEKIKKQVEQE 1542
Query: 538 SVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKEN 597
+ AL +S E EG ++Q L ++ + E + + E +L++ +
Sbjct: 1543 KCELQAALEEAE---ASLEHEEGKILRIQLELNQV---KSEVDRKIAEKDEEIDQLKRNH 1596
Query: 598 QRIADKLKNTGSAQ-------------LVGLAQENAAVSNTAGQDEATAKAVLEPIQSTS 644
RI + +++T A+ + G E N A + A A L ++T
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA---LRNYRNTQ 1653
Query: 645 LIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLA 704
G L T + S+ED L QL + + ++ AE L L
Sbjct: 1654 --GILKDTQIHLDDALRSQED------------LKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 705 LAEKSKEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHL 749
E+S++ +E+ AS+ + L + L TK+ E +S M +
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Score = 64.7 bits (156), Expect = 3e-10
Identities = 163/796 (20%), Positives = 323/796 (40%), Gaps = 94/796 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 939 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 991
Query: 63 TFRNLQLAKRVELLQD--ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
+L K + LQ+ + L + + +++K + + +++ EQ+ +DL+ +E+ +
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEK 1048
Query: 121 RLHIQFFE-----------ADEQHKHVEAE---LRSRLATLETEAAQHQAVVDGLTRKYM 166
+L + A E +E E L +L E E + Q+ ++ +
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+ +K++ +A++E + +E E + R + E+ + L E++S RLEE+ + ++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAE-RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 227 PFNDTKYSQYNALNVPLHNR--RHQLKMRDIAGQALAFVQDLVTALLNFHTY-------- 276
N + +++ + L +H+ + + V +L + N
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 277 TEQRIQIFPVDSAIDTISPLN---QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 333
+E +++I + S ++T+S +K + L + S ++ EE L +T +
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 334 ETTVKLK---TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ-DMK 389
+ + E L S + ++ Q++ L+ + E + A L+ S+ D
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 390 KMTAVFEKLQTYIALL--ALPSTEPD-GLLRTNYSSVLTNVGAALHGFHDVMKDISKHYS 446
+ +E+ Q A L AL + RT Y T+ + K +++
Sbjct: 1348 LLREQYEEEQESKAELQRALSKANTEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRL- 1403
Query: 447 QKAAIEH---------ELPTATQKLIT-TNDCILSSVVALTNGAGKIASFFSNNLDYFIA 496
+AA EH L Q+L D +L V TN A N D +A
Sbjct: 1404 -QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD--VERTNAACAALDKKQRNFDKILA 1460
Query: 497 SLSYGPKAASGFISPLSAECM---LQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLS 553
+ + E + K AY +SL + LE++ E + I
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ--LETLKRENKNLQQEISDL 1518
Query: 554 STESREGLAQQVQQSLEKISK-LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQL 612
+ + EG +++ + LEKI K +EQEK + A+ LE E +I QL
Sbjct: 1519 TEQIAEG-GKRIHE-LEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL-------RIQL 1569
Query: 613 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLI--KNH 670
++ A +DE + I+ ++ ++ T D+E + SR D I K
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIR---IVESMQSTLDAE---IRSRNDAIRLKKK 1623
Query: 671 YMARIVELTSQLQLAD---SKSVHFYAECRALSK----RLALAEKSKEALTEEMKLASQN 723
+ E+ QL A+ ++++ Y + + K L A +S+E L E++ + +
Sbjct: 1624 MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683
Query: 724 ISRLQDELTTTKRSYE 739
+ LQ E+ + + E
Sbjct: 1684 ANLLQAEIEELRATLE 1699
Score = 63.2 bits (152), Expect = 9e-10
Identities = 162/826 (19%), Positives = 315/826 (38%), Gaps = 150/826 (18%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
A ++ ++QK+ E +K A+ + L++ +V L+ Q++ + + L ++ D L
Sbjct: 856 ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENER 121
+QL +++ + + E E +++L+ +++ + DE +L+K I++
Sbjct: 916 KTKIQLEAKIKEVTERAEDEE----------EINAELTAKKRKLEDECSELKKDIDD--- 962
Query: 122 LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM---ETIEKLQNDKAK 178
L LA +E E + V LT + ETI KL +K
Sbjct: 963 ------------------LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA 1004
Query: 179 L-EVKSQTLEK-EAKECRLRT-EECQLQLKTLHEDLSGRLEES------LSIINEKVPFN 229
L E QTL+ +A+E ++ T + +++L+ +DL G LE+ L K+
Sbjct: 1005 LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-G 1063
Query: 230 DTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSA 289
D K +Q + +++ N + QL + ++ +I + S
Sbjct: 1064 DLKLAQESIMDI--ENEKQQLDEK----------------------LKKKEFEISNLQSK 1099
Query: 290 IDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 349
I+ L + + + E + + LEE + E + K +
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEI-------------EAERASRAKAEKQ----- 1141
Query: 350 ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPS 409
R L +L+ + E E + + +E++ KK A F+K++ + L
Sbjct: 1142 ----RSDLSRELEEISERLEEA---GGATSAQIEMN---KKREAEFQKMRRDLEEATLQH 1191
Query: 410 TEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ--------- 460
LR ++ + +G + V + + K S+ +L + +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 461 -KLITTNDCILSSVVA-----------LTNGAGKI---ASFFSNNLDY---FIASLSYGP 502
K+ T + LS + + LT G++ + FS LD ++ LS G
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 503 KAASGFISPLSAECMLQYKKKAA---AYMKSLRKPLLESVPYEE-----ALANRRILLSS 554
+A + I L + + K K A A S L YEE A R + ++
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 555 TESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA------DKLKNTG 608
TE + + ++++ +LE+ K+ Q A+ +E N + A +L+N
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV 1431
Query: 609 SAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIK 668
++ + + NAA + + K + E Q S E + + IK
Sbjct: 1432 EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIK 1491
Query: 669 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 728
N Y E QL+ ++ + E L++++A K L + K Q LQ
Sbjct: 1492 NAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547
Query: 729 DELTTTKRSYEDQLSMMSDHLCSMNET-------LSKQREEIDTLK 767
L + S E + + +N+ ++++ EEID LK
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 36/247 (14%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
LQ + ++L + ++ ++ ++D L Q + +KL+ ++
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS----- 1741
Query: 66 NLQLAKRVELLQDELALSEPRGKKN-----------KKSGESSSQLSQEQKSVFD--EDL 112
Q+ +E + E +E + KK KK ++S+ L + +K++ +DL
Sbjct: 1742 --QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799
Query: 113 QKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL----------- 161
Q +++E E+L ++ +Q + +EA +R +E+E ++ V GL
Sbjct: 1800 QLRLDEAEQLALK--GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857
Query: 162 --TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESL 219
T + + I +LQ+ KL+ K ++ +++A+E ++ + + L +L EE
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE-EAEERA 1916
Query: 220 SIINEKV 226
I +V
Sbjct: 1917 DIAESQV 1923
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 72.4 bits (176), Expect = 2e-12
Identities = 158/768 (20%), Positives = 296/768 (38%), Gaps = 117/768 (15%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ ++D + L E+LK K+ + LQ +++ +QL K+++ LQ
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA 1119
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + ++ +S +++Q+S +L++ E E E +K EA
Sbjct: 1120 RIEELE----EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K+ +++ +L L+ Q LEKE E ++ +
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+ ++T+ + G LE+ + +++ +LK ++ Q
Sbjct: 1236 DLASNVETVSK-AKGNLEKMCRTLEDQL---------------------SELKSKEEEQQ 1273
Query: 259 ALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGM 318
L + DL T QR + + +FS+ L E + V L G
Sbjct: 1274 RL--INDL----------TAQR----------GRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 319 LHLFESITEDTVTVLETTVKLKTFSEHL---TSYICFLRKILPYQLKSLEEECESSL-CT 374
F E+ LE +K K H + + C L + + EEE ES
Sbjct: 1312 -QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR------EQYEEEQESKAELQ 1364
Query: 375 SALRARNLELSQ-------DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNV 427
AL N E++Q D + T E+ + +A + E + +S+
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 428 GAALHGFHDVMKDISKHYSQKAAIEHE-------LPTATQKLITTN---DCILSSVVALT 477
+ D+M D+ + + AA++ + L QK T+ + +L
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLG 1484
Query: 478 NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLE 537
KI + + +LD + +L K IS L+ E + + K+ K ++ E
Sbjct: 1485 TELFKIKNAYEESLDQ-LETLKRENKNLQQEISDLT-EQIAEGGKRIHELEKIKKQVEQE 1542
Query: 538 SVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKEN 597
+ AL +S E EG ++Q L ++ + E + + E +L++ +
Sbjct: 1543 KCELQAALEEAE---ASLEHEEGKILRIQLELNQV---KSEVDRKIAEKDEEIDQLKRNH 1596
Query: 598 QRIADKLKNTGSAQ-------------LVGLAQENAAVSNTAGQDEATAKAVLEPIQSTS 644
RI + +++T A+ + G E N A + A A L ++T
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA---LRNYRNTQ 1653
Query: 645 LIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLA 704
G L T + S+ED L QL + + ++ AE L L
Sbjct: 1654 --GILKDTQIHLDDALRSQED------------LKEQLAMVERRANLLQAEIEELRATLE 1699
Query: 705 LAEKSKEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHL 749
E+S++ +E+ AS+ + L + L TK+ E +S M +
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Score = 64.7 bits (156), Expect = 3e-10
Identities = 163/796 (20%), Positives = 323/796 (40%), Gaps = 94/796 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 939 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 991
Query: 63 TFRNLQLAKRVELLQD--ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
+L K + LQ+ + L + + +++K + + +++ EQ+ +DL+ +E+ +
Sbjct: 992 DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEK 1048
Query: 121 RLHIQFFE-----------ADEQHKHVEAE---LRSRLATLETEAAQHQAVVDGLTRKYM 166
+L + A E +E E L +L E E + Q+ ++ +
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+ +K++ +A++E + +E E + R + E+ + L E++S RLEE+ + ++
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAE-RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 227 PFNDTKYSQYNALNVPLHNR--RHQLKMRDIAGQALAFVQDLVTALLNFHTY-------- 276
N + +++ + L +H+ + + V +L + N
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 277 TEQRIQIFPVDSAIDTISPLN---QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 333
+E +++I + S ++T+S +K + L + S ++ EE L +T +
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 334 ETTVKLK---TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ-DMK 389
+ + E L S + ++ Q++ L+ + E + A L+ S+ D
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 390 KMTAVFEKLQTYIALL--ALPSTEPD-GLLRTNYSSVLTNVGAALHGFHDVMKDISKHYS 446
+ +E+ Q A L AL + RT Y T+ + K +++
Sbjct: 1348 LLREQYEEEQESKAELQRALSKANTEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRL- 1403
Query: 447 QKAAIEH---------ELPTATQKLIT-TNDCILSSVVALTNGAGKIASFFSNNLDYFIA 496
+AA EH L Q+L D +L V TN A N D +A
Sbjct: 1404 -QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD--VERTNAACAALDKKQRNFDKILA 1460
Query: 497 SLSYGPKAASGFISPLSAECM---LQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLS 553
+ + E + K AY +SL + LE++ E + I
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ--LETLKRENKNLQQEISDL 1518
Query: 554 STESREGLAQQVQQSLEKISK-LEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQL 612
+ + EG +++ + LEKI K +EQEK + A+ LE E +I QL
Sbjct: 1519 TEQIAEG-GKRIHE-LEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL-------RIQL 1569
Query: 613 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLI--KNH 670
++ A +DE + I+ ++ ++ T D+E + SR D I K
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIR---IVESMQSTLDAE---IRSRNDAIRLKKK 1623
Query: 671 YMARIVELTSQLQLAD---SKSVHFYAECRALSK----RLALAEKSKEALTEEMKLASQN 723
+ E+ QL A+ ++++ Y + + K L A +S+E L E++ + +
Sbjct: 1624 MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683
Query: 724 ISRLQDELTTTKRSYE 739
+ LQ E+ + + E
Sbjct: 1684 ANLLQAEIEELRATLE 1699
Score = 63.2 bits (152), Expect = 9e-10
Identities = 162/826 (19%), Positives = 315/826 (38%), Gaps = 150/826 (18%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
A ++ ++QK+ E +K A+ + L++ +V L+ Q++ + + L ++ D L
Sbjct: 856 ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE--DLQKKIEENER 121
+QL +++ + + E E +++L+ +++ + DE +L+K I++
Sbjct: 916 KTKIQLEAKIKEVTERAEDEE----------EINAELTAKKRKLEDECSELKKDIDD--- 962
Query: 122 LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM---ETIEKLQNDKAK 178
L LA +E E + V LT + ETI KL +K
Sbjct: 963 ------------------LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA 1004
Query: 179 L-EVKSQTLEK-EAKECRLRT-EECQLQLKTLHEDLSGRLEES------LSIINEKVPFN 229
L E QTL+ +A+E ++ T + +++L+ +DL G LE+ L K+
Sbjct: 1005 LQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE-G 1063
Query: 230 DTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSA 289
D K +Q + +++ N + QL + ++ +I + S
Sbjct: 1064 DLKLAQESIMDI--ENEKQQLDEK----------------------LKKKEFEISNLQSK 1099
Query: 290 IDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 349
I+ L + + + E + + LEE + E + K +
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEI-------------EAERASRAKAEKQ----- 1141
Query: 350 ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPS 409
R L +L+ + E E + + +E++ KK A F+K++ + L
Sbjct: 1142 ----RSDLSRELEEISERLEEA---GGATSAQIEMN---KKREAEFQKMRRDLEEATLQH 1191
Query: 410 TEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ--------- 460
LR ++ + +G + V + + K S+ +L + +
Sbjct: 1192 EATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL 1251
Query: 461 -KLITTNDCILSSVVA-----------LTNGAGKI---ASFFSNNLDY---FIASLSYGP 502
K+ T + LS + + LT G++ + FS LD ++ LS G
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 503 KAASGFISPLSAECMLQYKKKAA---AYMKSLRKPLLESVPYEE-----ALANRRILLSS 554
+A + I L + + K K A A S L YEE A R + ++
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 555 TESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA------DKLKNTG 608
TE + + ++++ +LE+ K+ Q A+ +E N + A +L+N
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV 1431
Query: 609 SAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIK 668
++ + + NAA + + K + E Q S E + + IK
Sbjct: 1432 EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIK 1491
Query: 669 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 728
N Y E QL+ ++ + E L++++A K L + K Q LQ
Sbjct: 1492 NAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547
Query: 729 DELTTTKRSYEDQLSMMSDHLCSMNET-------LSKQREEIDTLK 767
L + S E + + +N+ ++++ EEID LK
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/247 (19%), Positives = 108/247 (43%), Gaps = 36/247 (14%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
LQ + ++L + ++ ++ ++D L Q + +KL+ ++
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS----- 1741
Query: 66 NLQLAKRVELLQDELALSEPRGKKN-----------KKSGESSSQLSQEQKSVFD--EDL 112
Q+ +E + E +E + KK KK ++S+ L + +K++ +DL
Sbjct: 1742 --QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799
Query: 113 QKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGL----------- 161
Q +++E E+L ++ +Q + +EA +R +E+E ++ V GL
Sbjct: 1800 QLRLDEAEQLALK--GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857
Query: 162 --TRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESL 219
T + + I +LQ+ KL+ K ++ +++A+E ++ + + L +L EE
Sbjct: 1858 YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELE-EAEERA 1916
Query: 220 SIINEKV 226
I +V
Sbjct: 1917 DIAESQV 1923
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 72.4 bits (176), Expect = 2e-12
Identities = 156/781 (19%), Positives = 294/781 (37%), Gaps = 78/781 (9%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ +D + + L E+LK K+ + LQ +++ +QL K+++ LQ
Sbjct: 1058 KLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA 1117
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + ++ +S +++Q+S +L++ E E E +K EA
Sbjct: 1118 RIEELE----EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K+ +++ +L L+ Q LEKE E ++
Sbjct: 1174 EFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 199 ECQLQLKTL------HEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR----RH 248
+ ++T+ E + LE+ LS I K ++ +A LH
Sbjct: 1234 DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSR 1293
Query: 249 QLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENA 308
QL +D L+ + T + E + Q+ A T++ Q
Sbjct: 1294 QLDEKDAMVSQLSRGKQAFTQQIE-----ELKRQLEEETKAKSTLAHALQSARHDCDLLR 1348
Query: 309 SYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEEC 368
+E L +++ V + K +T + T + +K L +L+ EE
Sbjct: 1349 EQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV 1408
Query: 369 E--SSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTN 426
E +S C S L L +++ + E+ + A +AL +
Sbjct: 1409 EAVNSKCAS-LEKTKQRLQNEVEDLMIDVER--SNAACIALDKKQ--------------- 1450
Query: 427 VGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASF 486
F V+ + + Y + A EL A+QK +L+ K+ +
Sbjct: 1451 -----RNFDKVLAEWKQKYEETQA---EL-EASQK----------ESRSLSTELFKVKNA 1491
Query: 487 FSNNLDYFIASLSYGPKAASGFISPLSAECM--------LQYKKKAAAYMKSLRKPLLES 538
+ +LD+ + +L K IS L+ + L+ KK + KS + LE
Sbjct: 1492 YEESLDH-LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE 1550
Query: 539 VPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQ 598
+IL E + ++ ++ EK +L+Q K + + + + L+ E +
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIR 1610
Query: 599 RIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVP 658
D L+ ++ G E N A + A A L Q L T D+
Sbjct: 1611 SRNDALRI--KKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI-LKDTQLHLDDAIRG 1667
Query: 659 DVESREDLI-----KNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEAL 713
+ +E L N A + EL + L+ + E S+R+ L +L
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 714 TEEMKLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSS 770
K +IS++Q +++ R+ E++ M E L K+++ L+
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1787
Query: 771 K 771
K
Sbjct: 1788 K 1788
Score = 55.8 bits (133), Expect = 1e-07
Identities = 72/353 (20%), Positives = 153/353 (43%), Gaps = 40/353 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 937 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
Query: 63 TFRNLQLAKRVELLQ-------DEL--------ALSEPRGKKNKKSGESSSQLSQEQKSV 107
+L K + LQ D+L L++ + K ++ + L QE+K
Sbjct: 990 DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC 1049
Query: 108 FD-EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 166
D E ++K+E + +L + E K +L +L E E + Q ++ +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTENDKQ---QLNEKLKKKEFEMSNLQGKIEDEQALAI 1106
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+ +K++ +A++E + +E E + R + E+ + L E++S RLEE+ + ++
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAE-RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 227 PFNDTKYSQYNALNVPLHNRRHQ-----LKMRDIAGQALAFVQDLVTALLNFHTYTEQ-- 279
N + +++ + L Q +R ++A + + + +L E+
Sbjct: 1166 EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEK 1225
Query: 280 ---RIQIFPVDSAIDTISPLN---QKFSQYLHENASYVRPLEEGMLHLFESIT 326
+++I + S ++T+S +K + L + S ++ EE L ++
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELS 1278
Score = 41.6 bits (96), Expect = 0.003
Identities = 52/253 (20%), Positives = 105/253 (41%), Gaps = 56/253 (22%)
Query: 533 KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIK 592
KPLL+S E+ +AN + ++ +++ E+++K E +++ LE ++ +
Sbjct: 841 KPLLKSAETEKEMAN-------------MKEEFEKTKEELAKTEAKRKE--LEEKMVTLM 885
Query: 593 LEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRT 652
EK + ++ Q A A +E + + IQ + I +T
Sbjct: 886 QEKNDLQL----------------QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTER 929
Query: 653 SDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEA 712
++ E E++ ELT++ + + + + L LA EK K A
Sbjct: 930 AEDE-------EEI--------NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 974
Query: 713 -------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCSMNETLSKQREE 762
LTEEM + I++L E + +++ D L M D + ++ + +K ++
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQ 1034
Query: 763 IDTLKMSSKGNSK 775
+D L+ S + K
Sbjct: 1035 VDDLEGSLEQEKK 1047
Score = 33.9 bits (76), Expect = 0.60
Identities = 47/266 (17%), Positives = 102/266 (38%), Gaps = 67/266 (25%)
Query: 7 QGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAA-LKEQLKMKDQSLRKLQQEMDSLTFR 65
+ ++QK+ ++ + Q++ + + A+S A L EQ+ + +KL++E L
Sbjct: 1172 EAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 66 NLQLAKRVEL--------------LQDELA---------------LSEPRGKKNKKSGES 96
LA +E L+D+L+ LS + + + +SGE
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEF 1291
Query: 97 SSQLSQEQKSVFD------------EDLQKKIEENERLHIQFFEADEQHKH--------- 135
S QL ++ V E+L++++EE + A + +H
Sbjct: 1292 SRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQY 1351
Query: 136 -----VEAELRSRLATL-----------ETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 179
+AEL+ ++ ET+A Q ++ +K + ++ + +
Sbjct: 1352 EEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 180 EVKSQTLEKEAKECRLRTEECQLQLK 205
K +LEK + + E+ + ++
Sbjct: 1412 NSKCASLEKTKQRLQNEVEDLMIDVE 1437
Score = 30.8 bits (68), Expect = 5.0
Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 8/104 (7%)
Query: 15 QEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVE 74
++ KL A+ + L+ V EQ ++ E +K LRK ++ + LT++ + K +
Sbjct: 1814 KQIQKLEARVRELESEVESEQKHNV---EAVK----GLRKHERRVKELTYQTEEDRKNIL 1866
Query: 75 LLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEE 118
LQD + + + K K+ E + + S + F LQ ++EE
Sbjct: 1867 RLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKF-RKLQHELEE 1909
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 68.6 bits (166), Expect = 2e-11
Identities = 149/753 (19%), Positives = 288/753 (38%), Gaps = 84/753 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+A+L G+ + L Q ++ + + L+ V + Q+ + + + + KLQ E++S+
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 63 TF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE- 110
T + ++LAK V LQD L + ++ QL +E+ S+ D+
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 111 DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME-- 167
D + + ++N HI K + S + LE + Q ++ LT++Y E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 168 -TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+KL+ K +L Q +L L DL + + ++ ++
Sbjct: 1413 AAYDKLEKTKNRL---------------------QQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 227 PFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFP 285
F+ + N + R R + + R+ +AL+ + L AL E
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL---EAKEELERTNKM 1508
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ + ++ + + +HE R LE M + + E+ L+ T K
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKL---R 1564
Query: 346 LTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 405
L + L+ L++ +E+ E + +L + + + E + AL
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEYETELEDERKQRALA 1615
Query: 406 ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 465
A + +G L+ + +A+ G + +K + K +Q + EL A
Sbjct: 1616 AAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR--- 1668
Query: 466 NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA-----------ASGFISPLSA 514
+ A K A +L L+ +A A S LS
Sbjct: 1669 -----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 515 ECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS 573
LQ K++ A + L + L E EA+++R + +T+ E L+ ++
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQ 1781
Query: 574 KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATA 633
K E ++ + + + KL + + K K+T +A +AQ V A + +A
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 634 KAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFY 693
K++ + + L L + D + +E K + AR+ +L QL+ A+ +S
Sbjct: 1842 KSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRIN 1897
Query: 694 AECRALSKRLALAEKSKEALTEEMKLASQNISR 726
A R L + L A +S EA+ E+ + R
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 64.7 bits (156), Expect = 3e-10
Identities = 173/870 (19%), Positives = 340/870 (39%), Gaps = 112/870 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E + + Q+L E K+ Q L++ + +E+A L+ + + ++KL+ E+ +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 65 RNLQLAKRVELLQDELA---------------LSEPRGKKNKKSGESSSQLSQEQKSVFD 109
+N +L+K +LL++ ++ L++ + K E +L +E+KS +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 110 -EDLQKKIEENER--------LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 160
E L++K+E + L Q E Q E EL++ LA L+ E AQ +
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 161 LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC-----RLRTE-ECQLQLKTLHEDLSGR 214
+ R+ I LQ D EK+ ++ L+TE E L ++L +
Sbjct: 1113 I-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 215 LEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFH 274
E+ ++++ + + D + + A V ++H + ++ Q F + N
Sbjct: 1172 REQEVTVLKKAL---DEETRSHEA-QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 275 TYTEQRI----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE--- 327
T ++ ++ + A + +K + E S E L + + +
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 328 --DTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLE-- 383
++VT + + K L + L L + L+EE L S + R LE
Sbjct: 1288 EVESVTGMLNEAEGKAIK--LAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEE 1344
Query: 384 ---LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKD 440
L + + + L+ +I+ L + ++ L+ +++S + + F +++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1403
Query: 441 ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSY 500
+++ Y +KAA +L +L D + VV L N ++ S F L+
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDL---VVDLDN-QRQLVSNLEKKQRKFDQLLAE 1459
Query: 501 GPKAASGFISPLS-AECMLQYKKKAAAYMKSLRKPLLESVPYEEAL-ANRRILLSSTESR 558
+S + AE + K+ A SL + L E++ +E L ++L + E
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKAL---SLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 559 EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIAD----------KLKNTG 608
V +++ ++ K ++ E M E + +LE E Q D LK
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 609 SAQLVGLAQENAAVS----------NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVP 658
L ++N T +DE +A L L G L
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLEGDLKDLELQADS 1635
Query: 659 DVESREDLIK--NHYMARIVELTSQLQLA--------------DSKSVHFYAECRALSKR 702
++ RE+ IK A++ + +L+ A + K+ A+ L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 703 LALAEKS-------KEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHLCSM 752
LA AE++ KE L EE+ + + LQDE L E++L ++ +M
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 753 NETLSK---QREEIDTLKMSSKGNSKKNKS 779
++ + K Q E++ + + ++KN+S
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNES 1785
Score = 41.6 bits (96), Expect = 0.003
Identities = 163/817 (19%), Positives = 314/817 (38%), Gaps = 134/817 (16%)
Query: 21 RAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQ--- 77
+ Q Q+ V+ Q N AA LK+++ +L ++ L LQ+ ++ E +Q
Sbjct: 808 KRQQQLTAMKVI--QRNCAAY---LKLRNWQWWRLFTKVKPL----LQVTRQEEEMQAKE 858
Query: 78 DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
DEL ++ R +K K+ + SQL++E K++ E LQ + E + EA+E
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-------LYAEAEE-- 908
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 193
+R RLA + E + ++ + + ++LQ ++ K+ + LE++ +E
Sbjct: 909 ------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 194 RLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR 253
++ QL+ T + +LE+ + +++++ N L R L+ R
Sbjct: 963 EAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ--------------NNKLSKERKLLEER 1007
Query: 254 DIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQKFSQYLHENASYVR 312
+ DL T L + ++ +S I + +K + E R
Sbjct: 1008 ---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 313 PLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC-----------FLRKI--LPY 359
LE E I + + E ++L E L + + L+KI L
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 360 QLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTN 419
+ L+E+ +S RA + + + + E L+T + L ST LR
Sbjct: 1119 HISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAK 1171
Query: 420 YSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNG 479
+T + AL ++ H +Q + + A ++L + + L
Sbjct: 1172 REQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 480 AGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA------- 526
+ ++ L + + K + L ++C + +A
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 527 --YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQ-EKEH 581
++S+ L E+ LA LSS +++E L ++ +Q L +KL Q E+E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 582 WMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQLVGLAQENAAVSNTA 626
L+ QL AK LE+ N +++D K +T A G + + N
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 627 GQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD 686
Q E A A + ++ T L + D V D++++ L+ N L+
Sbjct: 1406 QQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN------------LEKKQ 1450
Query: 687 SKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS 746
K AE + +S + A EA E + + +++R +E K E M+
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 747 ---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
+ L S + + K E++ K + + ++ K++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 68.6 bits (166), Expect = 2e-11
Identities = 149/753 (19%), Positives = 288/753 (38%), Gaps = 84/753 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+A+L G+ + L Q ++ + + L+ V + Q+ + + + + KLQ E++S+
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 63 TF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE- 110
T + ++LAK V LQD L + ++ QL +E+ S+ D+
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 111 DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME-- 167
D + + ++N HI K + S + LE + Q ++ LT++Y E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 168 -TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+KL+ K +L Q +L L DL + + ++ ++
Sbjct: 1420 AAYDKLEKTKNRL---------------------QQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 227 PFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFP 285
F+ + N + R R + + R+ +AL+ + L AL E
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL---EAKEELERTNKM 1515
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ + ++ + + +HE R LE M + + E+ L+ T K
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKL---R 1571
Query: 346 LTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 405
L + L+ L++ +E+ E + +L + + + E + AL
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEYETELEDERKQRALA 1622
Query: 406 ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 465
A + +G L+ + +A+ G + +K + K +Q + EL A
Sbjct: 1623 AAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR--- 1675
Query: 466 NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA-----------ASGFISPLSA 514
+ A K A +L L+ +A A S LS
Sbjct: 1676 -----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 515 ECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS 573
LQ K++ A + L + L E EA+++R + +T+ E L+ ++
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQ 1788
Query: 574 KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATA 633
K E ++ + + + KL + + K K+T +A +AQ V A + +A
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 634 KAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFY 693
K++ + + L L + D + +E K + AR+ +L QL+ A+ +S
Sbjct: 1849 KSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRIN 1904
Query: 694 AECRALSKRLALAEKSKEALTEEMKLASQNISR 726
A R L + L A +S EA+ E+ + R
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 64.7 bits (156), Expect = 3e-10
Identities = 173/870 (19%), Positives = 340/870 (39%), Gaps = 112/870 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E + + Q+L E K+ Q L++ + +E+A L+ + + ++KL+ E+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 65 RNLQLAKRVELLQDELA---------------LSEPRGKKNKKSGESSSQLSQEQKSVFD 109
+N +L+K +LL++ ++ L++ + K E +L +E+KS +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 110 -EDLQKKIEENER--------LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 160
E L++K+E + L Q E Q E EL++ LA L+ E AQ +
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 161 LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC-----RLRTE-ECQLQLKTLHEDLSGR 214
+ R+ I LQ D EK+ ++ L+TE E L ++L +
Sbjct: 1120 I-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 215 LEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFH 274
E+ ++++ + + D + + A V ++H + ++ Q F + N
Sbjct: 1179 REQEVTVLKKAL---DEETRSHEA-QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 275 TYTEQRI----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE--- 327
T ++ ++ + A + +K + E S E L + + +
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 328 --DTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLE-- 383
++VT + + K L + L L + L+EE L S + R LE
Sbjct: 1295 EVESVTGMLNEAEGKAIK--LAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEE 1351
Query: 384 ---LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKD 440
L + + + L+ +I+ L + ++ L+ +++S + + F +++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1410
Query: 441 ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSY 500
+++ Y +KAA +L +L D + VV L N ++ S F L+
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDL---VVDLDN-QRQLVSNLEKKQRKFDQLLAE 1466
Query: 501 GPKAASGFISPLS-AECMLQYKKKAAAYMKSLRKPLLESVPYEEAL-ANRRILLSSTESR 558
+S + AE + K+ A SL + L E++ +E L ++L + E
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKAL---SLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 559 EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIAD----------KLKNTG 608
V +++ ++ K ++ E M E + +LE E Q D LK
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 609 SAQLVGLAQENAAVS----------NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVP 658
L ++N T +DE +A L L G L
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLEGDLKDLELQADS 1642
Query: 659 DVESREDLIK--NHYMARIVELTSQLQLA--------------DSKSVHFYAECRALSKR 702
++ RE+ IK A++ + +L+ A + K+ A+ L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 703 LALAEKS-------KEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHLCSM 752
LA AE++ KE L EE+ + + LQDE L E++L ++ +M
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 753 NETLSK---QREEIDTLKMSSKGNSKKNKS 779
++ + K Q E++ + + ++KN+S
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNES 1792
Score = 41.6 bits (96), Expect = 0.003
Identities = 163/817 (19%), Positives = 314/817 (38%), Gaps = 134/817 (16%)
Query: 21 RAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQ--- 77
+ Q Q+ V+ Q N AA LK+++ +L ++ L LQ+ ++ E +Q
Sbjct: 815 KRQQQLTAMKVI--QRNCAAY---LKLRNWQWWRLFTKVKPL----LQVTRQEEEMQAKE 865
Query: 78 DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
DEL ++ R +K K+ + SQL++E K++ E LQ + E + EA+E
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-------LYAEAEE-- 915
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 193
+R RLA + E + ++ + + ++LQ ++ K+ + LE++ +E
Sbjct: 916 ------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 194 RLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR 253
++ QL+ T + +LE+ + +++++ N L R L+ R
Sbjct: 970 EAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ--------------NNKLSKERKLLEER 1014
Query: 254 DIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQKFSQYLHENASYVR 312
+ DL T L + ++ +S I + +K + E R
Sbjct: 1015 ---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 313 PLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC-----------FLRKI--LPY 359
LE E I + + E ++L E L + + L+KI L
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 360 QLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTN 419
+ L+E+ +S RA + + + + E L+T + L ST LR
Sbjct: 1126 HISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAK 1178
Query: 420 YSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNG 479
+T + AL ++ H +Q + + A ++L + + L
Sbjct: 1179 REQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 480 AGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA------- 526
+ ++ L + + K + L ++C + +A
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 527 --YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQ-EKEH 581
++S+ L E+ LA LSS +++E L ++ +Q L +KL Q E+E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 582 WMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQLVGLAQENAAVSNTA 626
L+ QL AK LE+ N +++D K +T A G + + N
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 627 GQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD 686
Q E A A + ++ T L + D V D++++ L+ N L+
Sbjct: 1413 QQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN------------LEKKQ 1457
Query: 687 SKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS 746
K AE + +S + A EA E + + +++R +E K E M+
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 747 ---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
+ L S + + K E++ K + + ++ K++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 68.2 bits (165), Expect = 3e-11
Identities = 146/769 (18%), Positives = 310/769 (40%), Gaps = 54/769 (7%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ +D + + L E+L+ K+ + L +++ +QL K+++ LQ
Sbjct: 1057 KLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E G++ + S ++ +++Q+S +L++ E E E +K EA
Sbjct: 1117 RI---EELGEEIEAERASRAK-AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREA 1172
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A+V L +K+ +++ +L L+ Q LEKE E ++ T+
Sbjct: 1173 EFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+ + + + G LE+ + ++V TK + L L +R +L+ AG+
Sbjct: 1233 DLSSNAEAISK-AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTE--AGE 1289
Query: 259 ALAFVQD---LVTALLNFHTYTEQRI-----QIFPVDSAIDTISPLNQKFSQYLHENASY 310
+ + LV+ L + Q+I Q+ A + ++ Q
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 311 VRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECES 370
+EG L ++++ V + K +T + T + +K L +L+ EE E
Sbjct: 1350 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE- 1408
Query: 371 SLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAA 430
A+ A+ L + +++ E L + R+N + +
Sbjct: 1409 -----AVNAKCASLEKTKQRLQNEVEDLMLDVE-------------RSN--AACAALDKK 1448
Query: 431 LHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNN 490
F V+ + + Y + A E E + ++T + +V + + + N
Sbjct: 1449 QRNFDKVLSEWKQKYEETQA-ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507
Query: 491 LDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRI 550
L I+ L+ + A G E + + ++ +++ + S+ +EE RI
Sbjct: 1508 LQQEISDLT--EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI-LRI 1564
Query: 551 LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQL---AKIKLEKENQRIADKLKNT 607
L + + + +++ + E+I +L++ + Q A+I+ + R+ K++
Sbjct: 1565 QLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGD 1624
Query: 608 GSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSD--SEVPDVESRED 665
+ + L N + + ++ + +L+ Q L L D ++ VE R +
Sbjct: 1625 LNEMEIQLNHANRLAAESL-RNYRNTQGILKETQ-LHLDDALRGQEDLKEQLAIVERRAN 1682
Query: 666 LIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNIS 725
L++ A I EL + L+ + E S+R+ L +L K ++S
Sbjct: 1683 LLQ----AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738
Query: 726 RLQ---DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 771
+LQ +E+ R+ E++ M E L K+++ L+ K
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1787
Score = 53.9 bits (128), Expect = 6e-07
Identities = 162/801 (20%), Positives = 326/801 (40%), Gaps = 120/801 (14%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 936 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 988
Query: 63 TFRNLQLAKRVELLQD--ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
+L+K + LQ+ + L + + +++K + + ++ EQ+ +DL+ +E+ +
Sbjct: 989 DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQV---DDLEGSLEQEK 1045
Query: 121 RLHIQFFEADEQHKHVEAELR-SRLATLETEAAQHQAVVDGLTRKYME---TIEKLQNDK 176
+L + + + + +E +L+ ++ +T++ E + Q + + L +K E I K+++++
Sbjct: 1046 KLRM---DLERAKRKLEGDLKLAQESTMDMENDKQQ-LDEKLEKKEFEISNLISKIEDEQ 1101
Query: 177 A---KLEVKSQTLEKEAKE----------CRLRTEECQLQLKTLHEDLSGRLEESLSIIN 223
A +L+ K + L+ +E R + E+ + L E++S RLEE+ +
Sbjct: 1102 AVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161
Query: 224 EKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI 283
+V N + +++ L RD+ L + +V AL H + +
Sbjct: 1162 AQVELNKKREAEFQKLR------------RDLEEATLQH-EAMVAALRKKHADS-----M 1203
Query: 284 FPVDSAIDTISPLNQKFSQY----------LHENASYVRPLEEGMLHLFESITEDTVTVL 333
+ ID + + QK + L NA + + + + S+ ED V+ L
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSL-EDQVSEL 1262
Query: 334 ET-TVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMT 392
+T + + LT+ L+ + L+E + +L + R++ Q +
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE--KDALVSQLSRSKQASTQQIEELKH 1320
Query: 393 AVFEKLQTYIALL-ALPSTEPD-GLLRTNYSSVLTNVGAALHGFHDVMKDI----SKHYS 446
+ E+ + AL AL S+ D LLR Y ++ +K+ +
Sbjct: 1321 QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 447 QKAAIEHELPTATQKL---ITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPK 503
EL A +KL + + + +V A K N ++ + +
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 504 AASGF------ISPLSAECMLQYKKKAAAYMKSLRKPLLESVP-------YEEAL----- 545
A + + +E +Y++ A S ++ S YEE+L
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET 1500
Query: 546 ---ANRRILLSSTESREGLAQQVQQ--SLEKISK-LEQEKEHWMLEAQLAKIKLEKENQR 599
N+ + ++ E +A+ +Q LEKI K +EQEK + A+ LE E +
Sbjct: 1501 LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGK 1560
Query: 600 IADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPD 659
I QL L Q + V + + + T ++ T+ T D+E
Sbjct: 1561 IL-------RIQL-ELNQVKSEVDRKIAEKDEEIDQLKR--NHTRVVETMQSTLDAE--- 1607
Query: 660 VESREDL--IKNHYMARIVELTSQLQLAD---SKSVHFYAECRALSKRLAL----AEKSK 710
+ SR D +K + E+ QL A+ ++S+ Y + + K L A + +
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667
Query: 711 EALTEEMKLASQNISRLQDEL 731
E L E++ + + + LQ E+
Sbjct: 1668 EDLKEQLAIVERRANLLQAEI 1688
Score = 35.0 bits (79), Expect = 0.27
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 8/106 (7%)
Query: 15 QEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVE 74
++ KL A+ + L+ V +EQ +A E +K LRK ++ + LT++ + K V
Sbjct: 1813 KQIQKLEARVRELEGEVENEQKRNA---EAVK----GLRKHERRVKELTYQTEEDRKNVL 1865
Query: 75 LLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
LQD + + + K K+ E + + S S F LQ ++EE E
Sbjct: 1866 RLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKF-RKLQHELEEAE 1910
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 2/112 (1%)
Query: 651 RTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSK 710
+T D R++L + M +++ + LQL A+ ++L +
Sbjct: 861 KTKDELAKSEAKRKELEEK--MVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQL 918
Query: 711 EALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREE 762
EA +E+ ++ + ELT KR ED+ S + + + TL+K +E
Sbjct: 919 EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 970
Score = 30.8 bits (68), Expect = 5.0
Identities = 38/196 (19%), Positives = 86/196 (43%), Gaps = 8/196 (4%)
Query: 39 AALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSS 98
+ L +++ ++ +LR ++ L +QL L + L R +N + +
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESL-----RNYRNTQGILKET 1656
Query: 99 QLSQEQKSVFDEDLQKKIEENER-LHIQFFEADEQHKHVEAELRSR-LATLET-EAAQHQ 155
QL + EDL++++ ER ++ E +E +E RSR +A E +A++
Sbjct: 1657 QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERV 1716
Query: 156 AVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRL 215
++ + T +KL+ND ++L+ + + + +E++ + ++ + E+L
Sbjct: 1717 QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQ 1776
Query: 216 EESLSIINEKVPFNDT 231
+ S + K T
Sbjct: 1777 DTSAHLERMKKNLEQT 1792
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.0 bits (162), Expect = 6e-11
Identities = 148/744 (19%), Positives = 286/744 (38%), Gaps = 84/744 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+A+L G+ + L Q ++ + + L+ V + Q+ + + + + KLQ E++S+
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 63 TF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE- 110
T + ++LAK V LQD L + ++ QL +E+ S+ D+
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 111 DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME-- 167
D + + ++N HI K + S + LE + Q ++ LT++Y E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 168 -TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+KL+ K +L Q +L L DL + + ++ ++
Sbjct: 1420 AAYDKLEKTKNRL---------------------QQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 227 PFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFP 285
F+ + N + R R + + R+ +AL+ + L AL E
Sbjct: 1459 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL---EAKEELERTNKM 1515
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ + ++ + + +HE R LE M + + E+ L+ T K
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKL---R 1571
Query: 346 LTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 405
L + L+ L++ +E+ E + +L + + + E + AL
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEYETELEDERKQRALA 1622
Query: 406 ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 465
A + +G L+ + +A+ G + +K + K +Q + EL A
Sbjct: 1623 AAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR--- 1675
Query: 466 NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA-----------ASGFISPLSA 514
+ A K A +L L+ +A A S LS
Sbjct: 1676 -----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 515 ECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS 573
LQ K++ A + L + L E EA+++R + +T+ E L+ ++
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQ 1788
Query: 574 KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATA 633
K E ++ + + + KL + + K K+T +A +AQ V A + +A
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Query: 634 KAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFY 693
K++ + + L L + D + +E K + AR+ +L QL+ A+ +S
Sbjct: 1849 KSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRIN 1904
Query: 694 AECRALSKRLALAEKSKEALTEEM 717
A R L + L A +S EA+ E+
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREV 1928
Score = 64.7 bits (156), Expect = 3e-10
Identities = 173/870 (19%), Positives = 340/870 (39%), Gaps = 112/870 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E + + Q+L E K+ Q L++ + +E+A L+ + + ++KL+ E+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 65 RNLQLAKRVELLQDELA---------------LSEPRGKKNKKSGESSSQLSQEQKSVFD 109
+N +L+K +LL++ ++ L++ + K E +L +E+KS +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 110 -EDLQKKIEENER--------LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 160
E L++K+E + L Q E Q E EL++ LA L+ E AQ +
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 161 LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC-----RLRTE-ECQLQLKTLHEDLSGR 214
+ R+ I LQ D EK+ ++ L+TE E L ++L +
Sbjct: 1120 I-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 215 LEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFH 274
E+ ++++ + + D + + A V ++H + ++ Q F + N
Sbjct: 1179 REQEVTVLKKAL---DEETRSHEA-QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 275 TYTEQRI----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE--- 327
T ++ ++ + A + +K + E S E L + + +
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 328 --DTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLE-- 383
++VT + + K L + L L + L+EE L S + R LE
Sbjct: 1295 EVESVTGMLNEAEGKAIK--LAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEE 1351
Query: 384 ---LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKD 440
L + + + L+ +I+ L + ++ L+ +++S + + F +++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1410
Query: 441 ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSY 500
+++ Y +KAA +L +L D + VV L N ++ S F L+
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDL---VVDLDN-QRQLVSNLEKKQRKFDQLLAE 1466
Query: 501 GPKAASGFISPLS-AECMLQYKKKAAAYMKSLRKPLLESVPYEEAL-ANRRILLSSTESR 558
+S + AE + K+ A SL + L E++ +E L ++L + E
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKAL---SLARALEEALEAKEELERTNKMLKAEMEDL 1523
Query: 559 EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIAD----------KLKNTG 608
V +++ ++ K ++ E M E + +LE E Q D LK
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 609 SAQLVGLAQENAAVS----------NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVP 658
L ++N T +DE +A L L G L
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLEGDLKDLELQADS 1642
Query: 659 DVESREDLIK--NHYMARIVELTSQLQLA--------------DSKSVHFYAECRALSKR 702
++ RE+ IK A++ + +L+ A + K+ A+ L +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 703 LALAEKS-------KEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHLCSM 752
LA AE++ KE L EE+ + + LQDE L E++L ++ +M
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 753 NETLSK---QREEIDTLKMSSKGNSKKNKS 779
++ + K Q E++ + + ++KN+S
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNES 1792
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/249 (22%), Positives = 109/249 (43%), Gaps = 45/249 (18%)
Query: 19 KLRAQNQVLKKGVVDEQANSAA-----------LKEQLKMKDQSLRKLQQEMDSLTFRNL 67
+ R Q + K+ + +E A+S + L+ ++ ++ L + Q M++++ R
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 68 QLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 127
+ ++ E L +ELA +KN ES+ Q + Q +++L+ K+ E E
Sbjct: 1768 KATQQAEQLSNELATERSTAQKN----ESARQQLERQ----NKELRSKLHEMEGA----- 1814
Query: 128 EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKL-QNDKAKLEVKSQTL 186
V+++ +S +A LE + AQ + V+ R+ + L Q DK E+ Q
Sbjct: 1815 --------VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866
Query: 187 E--KEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI----------INEKVPFNDTKYS 234
+ K A++ + + E+ ++K L L EES I ++E N+
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Query: 235 QYNALNVPL 243
+ NAL L
Sbjct: 1927 EVNALKSKL 1935
Score = 41.6 bits (96), Expect = 0.003
Identities = 163/817 (19%), Positives = 314/817 (38%), Gaps = 134/817 (16%)
Query: 21 RAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQ--- 77
+ Q Q+ V+ Q N AA LK+++ +L ++ L LQ+ ++ E +Q
Sbjct: 815 KRQQQLTAMKVI--QRNCAAY---LKLRNWQWWRLFTKVKPL----LQVTRQEEEMQAKE 865
Query: 78 DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
DEL ++ R +K K+ + SQL++E K++ E LQ + E + EA+E
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-------LYAEAEE-- 915
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 193
+R RLA + E + ++ + + ++LQ ++ K+ + LE++ +E
Sbjct: 916 ------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 194 RLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR 253
++ QL+ T + +LE+ + +++++ N L R L+ R
Sbjct: 970 EAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ--------------NNKLSKERKLLEER 1014
Query: 254 DIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQKFSQYLHENASYVR 312
+ DL T L + ++ +S I + +K + E R
Sbjct: 1015 ---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 313 PLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC-----------FLRKI--LPY 359
LE E I + + E ++L E L + + L+KI L
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 360 QLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTN 419
+ L+E+ +S RA + + + + E L+T + L ST LR
Sbjct: 1126 HISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAK 1178
Query: 420 YSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNG 479
+T + AL ++ H +Q + + A ++L + + L
Sbjct: 1179 REQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 480 AGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA------- 526
+ ++ L + + K + L ++C + +A
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 527 --YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQ-EKEH 581
++S+ L E+ LA LSS +++E L ++ +Q L +KL Q E+E
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 582 WMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQLVGLAQENAAVSNTA 626
L+ QL AK LE+ N +++D K +T A G + + N
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 627 GQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD 686
Q E A A + ++ T L + D V D++++ L+ N L+
Sbjct: 1413 QQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN------------LEKKQ 1457
Query: 687 SKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS 746
K AE + +S + A EA E + + +++R +E K E M+
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 747 ---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
+ L S + + K E++ K + + ++ K++
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 6e-11
Identities = 148/744 (19%), Positives = 286/744 (38%), Gaps = 84/744 (11%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+A+L G+ + L Q ++ + + L+ V + Q+ + + + + KLQ E++S+
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 63 TF-------RNLQLAKRV----ELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDE- 110
T + ++LAK V LQD L + ++ QL +E+ S+ D+
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 111 DLQKKIEENERLHIQFFEAD-EQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYME-- 167
D + + ++N HI K + S + LE + Q ++ LT++Y E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 168 -TIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+KL+ K +L Q +L L DL + + ++ ++
Sbjct: 1413 AAYDKLEKTKNRL---------------------QQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 227 PFNDTKYSQYNALNVPLHNR-RHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFP 285
F+ + N + R R + + R+ +AL+ + L AL E
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL---EAKEELERTNKM 1508
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ + ++ + + +HE R LE M + + E+ L+ T K
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQATEDAKL---R 1564
Query: 346 LTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALL 405
L + L+ L++ +E+ E + +L + + + E + AL
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEE---------KRRQLQRQLHEYETELEDERKQRALA 1615
Query: 406 ALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITT 465
A + +G L+ + +A+ G + +K + K +Q + EL A
Sbjct: 1616 AAAKKKLEGDLK----DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR--- 1668
Query: 466 NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA-----------ASGFISPLSA 514
+ A K A +L L+ +A A S LS
Sbjct: 1669 -----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 515 ECMLQ-YKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKIS 573
LQ K++ A + L + L E EA+++R + +T+ E L+ ++
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQ 1781
Query: 574 KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATA 633
K E ++ + + + KL + + K K+T +A +AQ V A + +A
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Query: 634 KAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFY 693
K++ + + L L + D + +E K + AR+ +L QL+ A+ +S
Sbjct: 1842 KSLKQ--KDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRIN 1897
Query: 694 AECRALSKRLALAEKSKEALTEEM 717
A R L + L A +S EA+ E+
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREV 1921
Score = 64.7 bits (156), Expect = 3e-10
Identities = 173/870 (19%), Positives = 340/870 (39%), Gaps = 112/870 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E + + Q+L E K+ Q L++ + +E+A L+ + + ++KL+ E+ +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 65 RNLQLAKRVELLQDELA---------------LSEPRGKKNKKSGESSSQLSQEQKSVFD 109
+N +L+K +LL++ ++ L++ + K E +L +E+KS +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 110 -EDLQKKIEENER--------LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDG 160
E L++K+E + L Q E Q E EL++ LA L+ E AQ +
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 161 LTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC-----RLRTE-ECQLQLKTLHEDLSGR 214
+ R+ I LQ D EK+ ++ L+TE E L ++L +
Sbjct: 1113 I-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 215 LEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFH 274
E+ ++++ + + D + + A V ++H + ++ Q F + N
Sbjct: 1172 REQEVTVLKKAL---DEETRSHEA-QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 275 TYTEQRI----QIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITE--- 327
T ++ ++ + A + +K + E S E L + + +
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 328 --DTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLE-- 383
++VT + + K L + L L + L+EE L S + R LE
Sbjct: 1288 EVESVTGMLNEAEGKAIK--LAKDVASLSSQLQDTQELLQEETRQKLNVST-KLRQLEEE 1344
Query: 384 ---LSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKD 440
L + + + L+ +I+ L + ++ L+ +++S + + F +++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1403
Query: 441 ISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSY 500
+++ Y +KAA +L +L D + VV L N ++ S F L+
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDL---VVDLDN-QRQLVSNLEKKQRKFDQLLAE 1459
Query: 501 GPKAASGFISPLS-AECMLQYKKKAAAYMKSLRKPLLESVPYEEAL-ANRRILLSSTESR 558
+S + AE + K+ A SL + L E++ +E L ++L + E
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKAL---SLARALEEALEAKEELERTNKMLKAEMEDL 1516
Query: 559 EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIAD----------KLKNTG 608
V +++ ++ K ++ E M E + +LE E Q D LK
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 609 SAQLVGLAQENAAVS----------NTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVP 658
L ++N T +DE +A L L G L
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLEGDLKDLELQADS 1635
Query: 659 DVESREDLIK--NHYMARIVELTSQLQLA--------------DSKSVHFYAECRALSKR 702
++ RE+ IK A++ + +L+ A + K+ A+ L +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 703 LALAEKS-------KEALTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHLCSM 752
LA AE++ KE L EE+ + + LQDE L E++L ++ +M
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 753 NETLSK---QREEIDTLKMSSKGNSKKNKS 779
++ + K Q E++ + + ++KN+S
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNES 1785
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/249 (22%), Positives = 109/249 (43%), Gaps = 45/249 (18%)
Query: 19 KLRAQNQVLKKGVVDEQANSAA-----------LKEQLKMKDQSLRKLQQEMDSLTFRNL 67
+ R Q + K+ + +E A+S + L+ ++ ++ L + Q M++++ R
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 68 QLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 127
+ ++ E L +ELA +KN ES+ Q + Q +++L+ K+ E E
Sbjct: 1761 KATQQAEQLSNELATERSTAQKN----ESARQQLERQ----NKELRSKLHEMEGA----- 1807
Query: 128 EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKL-QNDKAKLEVKSQTL 186
V+++ +S +A LE + AQ + V+ R+ + L Q DK E+ Q
Sbjct: 1808 --------VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859
Query: 187 E--KEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI----------INEKVPFNDTKYS 234
+ K A++ + + E+ ++K L L EES I ++E N+
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919
Query: 235 QYNALNVPL 243
+ NAL L
Sbjct: 1920 EVNALKSKL 1928
Score = 41.6 bits (96), Expect = 0.003
Identities = 163/817 (19%), Positives = 314/817 (38%), Gaps = 134/817 (16%)
Query: 21 RAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQ--- 77
+ Q Q+ V+ Q N AA LK+++ +L ++ L LQ+ ++ E +Q
Sbjct: 808 KRQQQLTAMKVI--QRNCAAY---LKLRNWQWWRLFTKVKPL----LQVTRQEEEMQAKE 858
Query: 78 DELALSEPRGKKN----KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
DEL ++ R +K K+ + SQL++E K++ E LQ + E + EA+E
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETE-------LYAEAEE-- 908
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKEC 193
+R RLA + E + ++ + + ++LQ ++ K+ + LE++ +E
Sbjct: 909 ------MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 194 RLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR 253
++ QL+ T + +LE+ + +++++ N L R L+ R
Sbjct: 963 EAARQKLQLEKVTAEAKIK-KLEDEILVMDDQ--------------NNKLSKERKLLEER 1007
Query: 254 DIAGQALAFVQDLVTALLNFHTYTEQRIQI-FPVDSAIDTISPLNQKFSQYLHENASYVR 312
+ DL T L + ++ +S I + +K + E R
Sbjct: 1008 ---------ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 313 PLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYIC-----------FLRKI--LPY 359
LE E I + + E ++L E L + + L+KI L
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 360 QLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTN 419
+ L+E+ +S RA + + + + E L+T + L ST LR
Sbjct: 1119 HISDLQEDLDSE------RAARNKAEKQKRDLGEELEALKTELE-DTLDSTATQQELRAK 1171
Query: 420 YSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNG 479
+T + AL ++ H +Q + + A ++L + + L
Sbjct: 1172 REQEVTVLKKALD------EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 480 AGKIASFFSN------NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAA------- 526
+ ++ L + + K + L ++C + +A
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 527 --YMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQ-EKEH 581
++S+ L E+ LA LSS +++E L ++ +Q L +KL Q E+E
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 582 WMLEAQL-----AKIKLEKE----NQRIADKLK------NTGSAQLVGLAQENAAVSNTA 626
L+ QL AK LE+ N +++D K +T A G + + N
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 627 GQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLAD 686
Q E A A + ++ T L + D V D++++ L+ N L+
Sbjct: 1406 QQYEEKA-AAYDKLEKTK--NRLQQELDDLVVDLDNQRQLVSN------------LEKKQ 1450
Query: 687 SKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS 746
K AE + +S + A EA E + + +++R +E K E M+
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 747 ---DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
+ L S + + K E++ K + + ++ K++
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 66.6 bits (161), Expect = 8e-11
Identities = 144/773 (18%), Positives = 300/773 (38%), Gaps = 50/773 (6%)
Query: 13 LAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKR 72
L + KL ++ ++ ++D + + L E+LK KD +LQ +++ LQ K+
Sbjct: 1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK 1108
Query: 73 VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQ 132
++ LQ + E + ++ ++ +++Q+S + +L++ E E E
Sbjct: 1109 IKELQARIEELE----EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIEL 1164
Query: 133 HKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKE 192
+K EAE LE QH+A+V L +K+ +++ +L L+ Q LEKE E
Sbjct: 1165 NKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1224
Query: 193 CRLRTEECQLQLKTLH------EDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNR 246
+L ++ ++++ E + LE+ LS K S+ L
Sbjct: 1225 FKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTE 1284
Query: 247 RHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ-RIQIFPVDSAIDTISPLNQKFSQYLH 305
+L + + + V L + F TE+ + Q+ + A + ++ Q
Sbjct: 1285 AGELSRQ--LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD 1342
Query: 306 ENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLE 365
+EG L ++++ V + K +T + T + +K L +L+ E
Sbjct: 1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE 1402
Query: 366 EECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLT 425
E+ E A+ A+ L + +++ E L + + D R N+ VL
Sbjct: 1403 EQVE------AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR-NFDKVLA 1455
Query: 426 NVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIAS 485
K +++ E E + ++T L + +
Sbjct: 1456 E---------------WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500
Query: 486 FFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEAL 545
+ NL+ IA L+ I L + Q + + A +L + E+ E
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELE-KSRKQIELEKADIQLALEE--AEAALEHEEA 1557
Query: 546 ANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLK 605
RI L T+ + + +++ + E+I +L++ + +E + + E ++ A +LK
Sbjct: 1558 KILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQR-TVETMQSALDAEVRSRNEAIRLK 1616
Query: 606 NTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL-IGTLTRTSD---SEVPDVE 661
L + + + + A + ++V ++ T L + R + ++ VE
Sbjct: 1617 KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
Query: 662 SREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLAS 721
R +L++ A + EL + L+ + E ++R+ L +L K
Sbjct: 1677 RRANLLQ----AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 1732
Query: 722 QNISRLQDEL---TTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 771
++ +LQ E+ + R+ E++ M E L K+++ L+ K
Sbjct: 1733 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Score = 60.8 bits (146), Expect = 5e-09
Identities = 158/848 (18%), Positives = 323/848 (38%), Gaps = 177/848 (20%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAAL---KEQLKMKDQSLRKLQQEMDS 61
EL+ K L QE + L+ Q Q + ++D + L K QL+ K + + + ++ +
Sbjct: 873 ELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE 932
Query: 62 LTFRNLQLAKRVELLQDE----------LALSEPRGKKNKKSGESSSQLSQEQKSVFDED 111
+ N +L + L+DE L L+ + +K K + E+ + E+ S DE
Sbjct: 933 I---NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
Query: 112 LQKKIEENERLH------IQFFEADEQH----KHVEAELRSRLATLETEAAQHQAV---- 157
+ K E + L + +A+E +++L ++ LE+ Q + +
Sbjct: 990 IAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049
Query: 158 ------VDGLTRKYMETIEKLQNDKAKLEVK-----------------SQTL----EKEA 190
++G + E+I L+NDK +L+ + QTL +K+
Sbjct: 1050 ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Query: 191 KECRLRTEECQLQLKTLH-----------------EDLSGRLEESLSIINEKVPFNDTKY 233
KE + R EE + +++ E+LS RLEE+ + + ++ N +
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKRE 1169
Query: 234 SQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTI 293
+++ LK+R +A + +V AL H + + + ID +
Sbjct: 1170 AEF-------------LKLRRDLEEATLQHEAMVAALRKKHADS-----VAELGEQIDNL 1211
Query: 294 SPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFL 353
+ QK + E F+ +D + +E+ K K E IC
Sbjct: 1212 QRVKQKLEKEKSE---------------FKLEIDDLSSSMESVSKSKANLEK----IC-- 1250
Query: 354 RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPD 413
++LE++ S R +N E+ + + ++T +LQT L+ E +
Sbjct: 1251 --------RTLEDQ------LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 414 GLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSV 473
S+++ + + F +++ + ++ ++ L A Q + +DC L
Sbjct: 1297 --------SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQS--SRHDCDLLRE 1346
Query: 474 VALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC---MLQYKKKAAAYMKS 530
GK A L A+ ++ + +Q ++ K
Sbjct: 1347 QYEEEQEGK-------------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 531 LRKPLLESVPYEEALANRRILLSSTESR-EGLAQQVQQSLEKISKLEQ--EKEHWMLEAQ 587
L + L +S EA+ + L T+ R +G + + +E+ + L +K+ +
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453
Query: 588 LA--KIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL 645
LA K K E+ + LK + S +NA +EA + ++ +L
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNA-------YEEALDQLETVKRENKNL 1506
Query: 646 IGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLAL 705
+ ++ + ++ +L K+ + + QL L ++++ + E + L +L L
Sbjct: 1507 EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 706 AEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDT 765
+ E + I+ +E+ KR+Y+ + M L + + R E
Sbjct: 1567 TQVKSE--------IDRKIAEKDEEIEQLKRNYQRTVETMQSAL----DAEVRSRNEAIR 1614
Query: 766 LKMSSKGN 773
LK +G+
Sbjct: 1615 LKKKMEGD 1622
Score = 56.6 bits (135), Expect = 9e-08
Identities = 166/813 (20%), Positives = 320/813 (39%), Gaps = 99/813 (12%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
+K E+ KLR L++ + +A AAL+ K S+ +L +++D+L +L
Sbjct: 1166 KKREAEFLKLRRD---LEEATLQHEAMVAALR---KKHADSVAELGEQIDNLQRVKQKLE 1219
Query: 71 KR---VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 127
K +L D+L+ S K+K + E + ++Q L + +NE +
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ-------LSEARGKNEEIQRSLS 1272
Query: 128 EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLE 187
E Q ++ L++ L + + +++V L+R ++ + K +LE +++
Sbjct: 1273 ELTTQ----KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328
Query: 188 KEAKECRLRTEECQLQLKTLHEDLSGR--LEESLSIINEKVPFNDTKYSQYNALN--VPL 243
A + +C L + E+ G+ L+ +LS N +V TKY + +A+ L
Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY-ETDAIQRTEEL 1387
Query: 244 HNRRHQL--KMRDIAGQALAFVQDLVTALLNFHTYTEQRIQ------IFPVDSAIDTISP 295
+ +L +++D Q A V A T+QR+Q + V+ A +
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEA-----VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Query: 296 LNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRK 355
L++K + A + EE L S+ E E KLK E + +++
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL-FKLKNAYEEALDQLETVKR 1501
Query: 356 ILPYQLKSLEEECESSLCTSALRARNL-ELSQDMKKMTAVFEKLQTYIALLALPSTEPDG 414
+ K+LE+E A + + EL + K++ EK +AL E +
Sbjct: 1502 ----ENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE--LEKADIQLAL-----EEAEA 1550
Query: 415 LLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVV 474
L + +L + L V +I + ++K +L Q+ + T L + V
Sbjct: 1551 ALEHEEAKIL-RIQLELT---QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 1606
Query: 475 ALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKP 534
N A ++ +L+ LS+ + A+ L++ + +K +
Sbjct: 1607 RSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE---------TLKHLRSVQGQLKDTQLH 1657
Query: 535 LLESVPYEEALANRRILLSSTESREGLAQ----QVQQSLEKISKLEQEKEHWMLEAQLAK 590
L +++ +E L + L+ E R L Q +++ +LE+ + + E +L++
Sbjct: 1658 LDDALRGQEDLKEQ---LAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714
Query: 591 IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAV----------LEPI 640
L +N + K L+ L E S A E AK L+
Sbjct: 1715 QLLHTQNTSLIHTKKKL-ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773
Query: 641 QSTSL-IGTLTRTSDSEVPDVESREDLIKNHYM-----------ARIVELTSQLQLADSK 688
Q TS + + + + V D++ R D + + RI EL +L+ K
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK 1833
Query: 689 SVHFYAECRALSKRLA-LAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD 747
+ R +R+ L +S+E ++L + +LQ ++ + KR E+ +
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDL-VDKLQVKVKSYKRQAEEADEQANA 1892
Query: 748 HLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
HL + Q E + + + S+ NK R
Sbjct: 1893 HLTKFRKA---QHELEEAEERADIAESQVNKLR 1922
Score = 44.7 bits (104), Expect = 3e-04
Identities = 51/248 (20%), Positives = 99/248 (39%), Gaps = 31/248 (12%)
Query: 551 LLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSA 610
L S E + L Q Q+ ++++ +E E + + + K EK+ A +L+
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE----- 1145
Query: 611 QLVGLAQENAAVSNTAGQDEATAKAVLE-----------PIQSTSLIGTLTRTSDSEVPD 659
+L +E V++T Q E K E +Q +++ L + V +
Sbjct: 1146 ELSERLEEAGGVTST--QIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203
Query: 660 VESREDLI----------KNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKS 709
+ + D + K+ + I +L+S ++ + CR L +L+ A
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 710 KEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMS 769
E + + + SRLQ E R E++ S++S L + ++Q EE+ +
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS-QLSRSKQAFTQQTEELK--RQL 1320
Query: 770 SKGNSKKN 777
+ N KN
Sbjct: 1321 EEENKAKN 1328
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/257 (21%), Positives = 107/257 (41%), Gaps = 37/257 (14%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
LQG+ + L + + + L K + A K + + L +E SL+
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE 1481
Query: 66 NLQLAKRVELLQDELALSEPRGKK-NKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
+L E D+L + K ++ + + Q+++ K++ + + +K E E+ I
Sbjct: 1482 LFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI 1541
Query: 125 QFF--EADEQHKHVEA-------ELRSRLATLETEAAQHQAVVDGLTRKYMETIE----- 170
Q EA+ +H EA EL + ++ + A+ ++ L R Y T+E
Sbjct: 1542 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 171 ----------------KLQNDKAKLEVKSQTLEKEAKEC--RLRTEECQLQLKTLHED-- 210
K++ D ++E++ ++A E LR+ + QL+ LH D
Sbjct: 1602 LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 1661
Query: 211 LSGR--LEESLSIINEK 225
L G+ L+E L+I+ +
Sbjct: 1662 LRGQEDLKEQLAIVERR 1678
Score = 32.0 bits (71), Expect = 2.3
Identities = 25/112 (22%), Positives = 48/112 (42%), Gaps = 2/112 (1%)
Query: 651 RTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSK 710
+T D R++L + + +V+ + LQL + +L A+
Sbjct: 859 KTKDELAKSEAKRKELEEK--LVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQL 916
Query: 711 EALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREE 762
EA +E+ +++ + ELT KR ED+ S + + + TL+K +E
Sbjct: 917 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 968
Score = 30.4 bits (67), Expect = 6.6
Identities = 22/101 (21%), Positives = 45/101 (44%)
Query: 50 QSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFD 109
+ LRK ++ + LT+++ + K V LQD + + + K K+ E + + + + F
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR 1898
Query: 110 EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETE 150
+ + E ER I + ++ SR+ E+E
Sbjct: 1899 KAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 66.2 bits (160), Expect = 1e-10
Identities = 161/787 (20%), Positives = 295/787 (37%), Gaps = 85/787 (10%)
Query: 2 ASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDS 61
+SA + + + L ++ +KLR QN L V + + E + + R ++S
Sbjct: 223 SSAPVDQEIKSLREKLNKLRQQNACL----VTQNHSLMTKFESIHFELTQSRAKVSMLES 278
Query: 62 LTFRNLQLAKRVELLQDELALSEPR-GKKNKKSGESSSQLSQEQKSVFDED--LQKKIEE 118
Q A V +L++++ E ++K E+ ++L Q QK V +++ LQ+ EE
Sbjct: 279 AQ----QQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEE 334
Query: 119 NERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAK 178
+L + E +Q K E + L E + Q +K E +EK+Q ++
Sbjct: 335 CIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQY----KKKVAEKLEKVQAEEEI 390
Query: 179 LEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNA 238
LE EKE K + E C G + L I+ EK+
Sbjct: 391 LERNLTNCEKENKRLQ---ERC------------GLYKSELEILKEKL----------RQ 425
Query: 239 LNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISP-LN 297
L +N + +L++ +A V A L TE R I ++S ++ L
Sbjct: 426 LKEENNNGKEKLRI-------MAVKNSEVMAQL-----TESRQSILKLESELENKDEILR 473
Query: 298 QKFSQYLHENASYVR-PLEEGMLHLFESITEDT---VTVLETTVKLKTFSEHLTSYICFL 353
KFS VR + L L + E + + LE + L + +L
Sbjct: 474 DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYL 533
Query: 354 RKILPYQLKSLEEEC-----ESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALP 408
K + E+ C + L S LR + +++K+ A Q +L+
Sbjct: 534 SKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCN 593
Query: 409 STEPDGLLRTNYSSVLTN-VGAALHGFHDVMKDISKHYSQK--AAIEHELPTATQKLITT 465
++ L SS+ T V H + +KD ++H K L T ++L T
Sbjct: 594 DSQESSKL----SSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
Query: 466 NDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECML--QYKKK 523
I + L S F + + S K S S L Q ++K
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 709
Query: 524 AAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLA-QQVQQSLEKISKLEQEKEHW 582
AY K + E+ L + + S E+ +++ + EK K+ E +H
Sbjct: 710 IVAYSSIAAK----NAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLE-QHK 764
Query: 583 MLEAQLAKI--KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPI 640
+E Q+ ++ +LEK++Q+ ++ K Q + +++ S E+ + E +
Sbjct: 765 EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824
Query: 641 QSTSLIGTLTRTSDSE---VPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECR 697
+ + L E V ++S ++ K + + +L + + + E
Sbjct: 825 KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
Query: 698 ALSKRLALAEKSKEALTEEMKLASQNISRLQDEL---TTTKRSYEDQLSMMSDHLCSMNE 754
L K L + S + +E+ + + + Q L T ED + + + + +
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
Query: 755 TLSKQRE 761
L KQRE
Sbjct: 945 ELQKQRE 951
Score = 55.1 bits (131), Expect = 2e-07
Identities = 111/591 (18%), Positives = 244/591 (41%), Gaps = 86/591 (14%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
+L+G +K ++ K + L+K + + + EQ + +L++ QQ + T
Sbjct: 864 QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQE--QKSVFDEDL--QKKIEENE 120
RN +L L+ +++ E +K ++S + +E + + + DL QK IE
Sbjct: 924 RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG 983
Query: 121 RLHIQFFEADEQHKHVEAELRSRLATLETEA---AQHQAVVDGLTRKYMETIEKLQNDKA 177
E D Q+K +++ + L+ + A H + +D + + +EK N
Sbjct: 984 TARQVKIEMD-QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVK 1042
Query: 178 KLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG---RLEESLSIINEKVPFNDTKYS 234
+LE + E E E + E + +L+ H +L +L+E ++ + + KY+
Sbjct: 1043 ELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYT 1102
Query: 235 QYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTIS 294
L L + +++ +++ ++ +D A+ +
Sbjct: 1103 TIKDLTAELRECKMEIE--------------------------DKKQELLEMDQALKERN 1136
Query: 295 -PLNQKFSQYLHENAS---YVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYI 350
L Q+ +Q H + + + +E+ ++ L ++ + + + E ++++ ++ L +
Sbjct: 1137 WELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAK 1196
Query: 351 CFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPST 410
LR+ L++ +E S L+ Q MK+M +V ++ + YIA
Sbjct: 1197 EQLREKEFIMLQNEQE-------ISQLKKEIERTQQRMKEMESVMKEQEQYIA------- 1242
Query: 411 EPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCIL 470
T Y + ++G L + + +++ A H+ A +++ L
Sbjct: 1243 -------TQYKEAI-DLGQEL---RLTREQVQNSHTELAEARHQQVQAQREIER-----L 1286
Query: 471 SSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYK-KKAAAYMK 529
SS + K N+L + + + E +Q + KK +A ++
Sbjct: 1287 SSELEDMKQLSKEKDAHGNHL---------AEELGASKVREAHLEARMQAEIKKLSAEVE 1337
Query: 530 SLRKPL-LESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEK 579
SL++ +E + ++E A +I S +S++ QQ+ + LEK +KLE E+
Sbjct: 1338 SLKEAYHMEMISHQENHAKWKI---SADSQKSSVQQLNEQLEK-AKLELEE 1384
Score = 50.4 bits (119), Expect = 6e-06
Identities = 152/807 (18%), Positives = 320/807 (39%), Gaps = 108/807 (13%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
++L + ++ A+N LK + + ++E+L K + KL+ EM + L L
Sbjct: 644 EELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLE 703
Query: 71 KRVE--------LLQDELALSEPRGKKNKKSGESSSQLSQEQKSV---FDEDLQKKIEEN 119
K++E + L + +KN+K + ++ E + + F++ + +E++
Sbjct: 704 KQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQH 763
Query: 120 -------ERLHIQFFEADEQHKHVEAEL----------RSRLATLETEAAQHQAVVDGLT 162
ERL Q + D+Q K E + + L +L+ + + +
Sbjct: 764 KEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 823
Query: 163 RKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH------EDLSGRLE 216
K E ++ LQN ++ +K + L+ + C+ EE L L L E +
Sbjct: 824 MKKDEALKALQNQVSEETIKVRQLDSALEICK---EELVLHLNQLEGNKEKFEKQLKKKS 880
Query: 217 ESLSIINEKVPFNDTKYSQYNALNVPL-HNRRHQLKMRDIAGQALAFVQDLVTALLNFHT 275
E + + +++ + + + NV L H + Q +M ++D T L +
Sbjct: 881 EEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS 940
Query: 276 YTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLET 335
EQ +Q +S+ + + + +K HE A R + + E T T +
Sbjct: 941 KLEQELQ-KQRESSAEKLRKMEEKCESAAHE-ADLKR----------QKVIELTGTARQV 988
Query: 336 TVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDM------K 389
+++ + E L+ + ++ L+ + E+ A+ L++ D K
Sbjct: 989 KIEMDQYKEELSK--------MEKEIMHLKRDGEN----KAMHLSQLDMILDQTKTELEK 1036
Query: 390 KMTAV--FEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQ 447
K AV EKLQ + + +L T + + + L + ++D+ Q
Sbjct: 1037 KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQE-LRDV----LQ 1091
Query: 448 KAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASG 507
KA + E T K +T + + + + ++ +D + ++ K +
Sbjct: 1092 KAQLSLEEKYTTIKDLTAE--LRECKMEIEDKKQELL-----EMDQALKERNWELKQRAA 1144
Query: 508 FISPLS---AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQ 564
++ L E + ++K +L K LE + + + L + ++E L ++
Sbjct: 1145 QVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQN--AKEQLREK 1202
Query: 565 ---VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNT-GSAQLVGLAQENA 620
+ Q+ ++IS+L++E E + + ++++ Q IA + K Q + L +E
Sbjct: 1203 EFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQV 1262
Query: 621 AVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTS 680
S+T A+A + +Q+ I L+ + ++ + +D NH L
Sbjct: 1263 QNSHT-----ELAEARHQQVQAQREIERLSSELE-DMKQLSKEKDAHGNH-------LAE 1309
Query: 681 QLQLADSKSVHFYAECRALSKRL-ALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 739
+L + + H A +A K+L A E KEA EM +N ++ + + K S +
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQ 1369
Query: 740 ---DQLSMMSDHLCSMNETLSKQREEI 763
+QL L +T+S +++
Sbjct: 1370 QLNEQLEKAKLELEEAQDTVSNLHQQV 1396
Score = 44.7 bits (104), Expect = 3e-04
Identities = 155/776 (19%), Positives = 292/776 (37%), Gaps = 119/776 (15%)
Query: 36 ANSAALKEQLKMKDQSLRKLQQEMDSLT-FRNLQLA---KRVELLQDELALSEPRGKKNK 91
AN A+L+ +LK+ + SL+ L +E+ S++ N A R E L ++ S P G N
Sbjct: 138 ANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP-GLLNY 196
Query: 92 KSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEA 151
E+ ++S D QKK +++ D++ K LR +L L +
Sbjct: 197 SPYENVCKISGSST-----DFQKK--PRDKMFSSSAPVDQEIK----SLREKLNKLRQQN 245
Query: 152 AQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHED- 210
A L K+ +L +AK+ + ++ A L + L+ + +D
Sbjct: 246 ACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDK 305
Query: 211 ----LSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDL 266
+LE+S ++ EK + L V L + Q K +
Sbjct: 306 VLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAE------------ 353
Query: 267 VTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESIT 326
QR + A+ L++ F QY + A + ++ E I
Sbjct: 354 -----------RQR------NEALYNAEELSKAFQQYKKKVAEKLEKVQAE-----EEIL 391
Query: 327 EDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQ 386
E +T E + K L+E C L S L +L Q
Sbjct: 392 ERNLTNCEK------------------------ENKRLQERC--GLYKSELEILKEKLRQ 425
Query: 387 DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYS 446
++ EKL+ ++A+ ++E L + S+L + + L ++++D +
Sbjct: 426 LKEENNNGKEKLR----IMAVKNSEVMAQLTESRQSIL-KLESELENKDEILRDKFSLMN 480
Query: 447 QKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAAS 506
+ ++ + ++L I SS V L + KI S + F SY K
Sbjct: 481 ENRELKVRVAAQNERLDLCQQEIESSRVELRS-LEKIISQLPLKRELF-GFKSYLSKYQM 538
Query: 507 GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQ 566
S C+ + + K ++ ++ AN L ++ S+ +
Sbjct: 539 SSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN---LTANQLSQSLITCNDS 595
Query: 567 QSLEKISKLEQEKE----HWMLEA------QLAKIKLEKENQRIADKLKNTGSAQLVGLA 616
Q K+S LE E H + E+ + EKE QR+ ++ + +L+ +
Sbjct: 596 QESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT-KLIQIE 654
Query: 617 QENAAV----SNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRED---LIKN 669
EN+ + ++ Q + + +LE ++S + + S++ +E + + + +
Sbjct: 655 AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYS 714
Query: 670 HYMARIVELTSQLQLADSKSVHFYAECRALSKRLALA-EKSKEALTEEMKLASQNISRLQ 728
A+ EL +L + K +++ LA EK+K+ E+ K + I RL+
Sbjct: 715 SIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
Query: 729 DELTTTKRSYEDQLSMMS----DHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
+L + +++Q MS D +C + E +D L SKG KK +
Sbjct: 775 AQLEKKDQQFKEQEKTMSMLQQDIICKQHHL-----ESLDRLLTESKGEMKKENMK 825
Score = 40.4 bits (93), Expect = 0.006
Identities = 147/808 (18%), Positives = 304/808 (37%), Gaps = 128/808 (15%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
+EL+ K + L ++S L +N+ LK V AA E+L + Q + + E+ SL
Sbjct: 463 SELENKDEILRDKFS-LMNENRELKVRV-------AAQNERLDLCQQEIESSRVELRSLE 514
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLH 123
QL + EL + LS+ + SS ++E + + + K + R+
Sbjct: 515 KIISQLPLKRELFGFKSYLSKY---------QMSSFSNKEDRCIGCCEANKLVISELRIK 565
Query: 124 IQFFEADEQHKHV---------------EAELRSRLATLETEAAQ---HQAVVDGLTRKY 165
+ EA+ Q H +++ S+L++LETE + HQ V + + +
Sbjct: 566 LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQ-VAESVKDQN 624
Query: 166 METIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEK 225
T+ K Q +K + + + E K ++ E L++ H +I E+
Sbjct: 625 QHTMNK-QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRT------SQFQLIQEE 677
Query: 226 VPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFP 285
+ L ++ + + +M Q L + L E++I
Sbjct: 678 L------------LEKASNSSKLESEMTKKCSQLLTLEKQL-----------EEKIV--- 711
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESIT---EDTVTV-LETTVKLKT 341
A +I+ N + Q L E +R LE + E I E + LE +++
Sbjct: 712 ---AYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEK 768
Query: 342 FSEHLTSYICFLRKILPYQLKSLEEECESSLCTS--------ALRARNLELSQDMKKMTA 393
E L + + + Q K++ + +C L E+ ++ K
Sbjct: 769 QIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDE 828
Query: 394 VFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH 453
+ LQ ++ + + D L ++ ++ K + K + ++
Sbjct: 829 ALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
Query: 454 ELPTATQKLITTND--CILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISP 511
EL L T++ IL + + + + L+ L +S
Sbjct: 889 ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ-------VSK 941
Query: 512 LSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEK 571
L E Q + A K K ES +E L ++++ + +R+ + ++ Q E+
Sbjct: 942 LEQELQKQRESSAEKLRKMEEK--CESAAHEADLKRQKVIELTGTARQ-VKIEMDQYKEE 998
Query: 572 ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEA 631
+SK+E+E H LK G + + L+Q + + T + E
Sbjct: 999 LSKMEKEIMH----------------------LKRDGENKAMHLSQLDMILDQTKTELEK 1036
Query: 632 TAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQL-QLADSKSV 690
AV E + L ++++E+ + + ++++ EL S L QL + + V
Sbjct: 1037 KTNAVKE-------LEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDV 1089
Query: 691 HFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLC 750
A+ K + + + E +M++ + L+ + +R++E L + +
Sbjct: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE--LKQRAAQVT 1147
Query: 751 SMNETLSKQREEIDTLKMSSKGNSKKNK 778
++ T+ + R E++ + +G +K++
Sbjct: 1148 HLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 65.9 bits (159), Expect = 1e-10
Identities = 160/862 (18%), Positives = 307/862 (35%), Gaps = 112/862 (12%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
Q+L + KL + L + + QA A LK QL K++ L+ ++ +
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL 1103
Query: 71 KRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEAD 130
K++ L+ +++ + ++ +S +S +++QK E+L+ E E
Sbjct: 1104 KKIRELESQISELQ----EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 131 EQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQND-------KAKLEVKS 183
E E E+ TLE EA H+A + + +K+ + +E+L KA LE
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 184 QTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTK------YSQYN 237
QTLE E E E ++ L+ + R + + +V FN+ + +
Sbjct: 1220 QTLENERGEL---ANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276
Query: 238 ALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALL--NFHTYTEQRIQIFPVDSAIDTISP 295
L V L N L D L + + L E+ Q + + + +
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 296 LNQKFSQYLHENASYVRPLEEGMLHLFESIT------EDTVTVLETTVKLKT-------- 341
F + L E LE+ + L + ED+V LET ++K
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 342 FSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTY 401
S+ + K+ + + +E + + R L + KK + + +T
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 402 IALLALPSTEPDGLLRTNYSSVL------------------------TNVGAALHGFHDV 437
A A + R + L T + + DV
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 438 MKDISKHYSQKAAIE---HELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYF 494
K + + K A+E E+ T ++L + + L + + F +L
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 495 IASLSYGPKAASGFISPLSAECMLQYKKK--AAAYMKSLRKPLLESVPY--------EEA 544
K + + AE + K++ A A K L L + + +EA
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 545 LANRRILLSSTESREGLAQQVQQSLEKI--SKLEQEKEHWMLEAQL------------AK 590
+ R L + + + S E+I E EK+ +EA++ AK
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 591 IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLT 650
+ ++E +AD++ N+ + L ++ + A +E + E +T LI
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE----ELEEEQGNTELINDRL 1752
Query: 651 RTSDSEVPDVESREDLIKNHYM----------ARIVELTSQLQ-LADSKSVHFYAECRAL 699
+ ++ ++ + + +L ++H + EL +LQ + + + A AL
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 700 SKRLALAEKSKEALTEEMKLASQNISRLQ----------DELTTTKRSYEDQLSMMSDHL 749
++A E+ + T+E + A + + R + D+ Y+DQ S L
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 750 CSMNETLSKQREEIDTLKMSSK 771
+ L + EE S +
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRR 1894
Score = 58.2 bits (139), Expect = 3e-08
Identities = 152/768 (19%), Positives = 302/768 (39%), Gaps = 106/768 (13%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E + + Q L E K++ Q L++ + +E++ L+ + + L+KL++E L
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
+N +LAK +LL+D +A + ++ +S ++L + +++ DL++++ E+
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-TDLEERLRREEK--- 1041
Query: 125 QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQ 184
Q E ++ + +E + L + A+ QA + L + + E+LQ A++E ++
Sbjct: 1042 QRQELEKTRRKLEGD----STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA 1097
Query: 185 TLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLH 244
K+ R E + Q+ L EDL +K + + L L
Sbjct: 1098 QKNMALKKIR----ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153
Query: 245 NRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYL 304
+ Q ++R Q + ++ + H E +IQ + QK SQ +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTH---EAQIQ------------EMRQKHSQAV 1198
Query: 305 HENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSL 364
E A + E T V K K E+ + K+L L
Sbjct: 1199 EELAEQL---------------EQTKRVKANLEKAKQTLENERGELANEVKVL------L 1237
Query: 365 EEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL--RTNYSS 422
+ + +S + A+ EL + V +L + L + GLL + SS
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 423 VLTNVGAALHG-FHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAG 481
LT +AL D + + + QK ++ +L + + + + A N
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 482 KIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPY 541
+IA+ + +A + + + G + E + K+K ++ L S +
Sbjct: 1358 QIATLHAQ-----VADMKKKMEDSVGCL-----ETAEEVKRKLQKDLEGL------SQRH 1401
Query: 542 EEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIA 601
EE +A + + E ++QQ L+ L + +H A + K +K +Q +A
Sbjct: 1402 EEKVA-------AYDKLEKTKTRLQQELD---DLLVDLDHQRQSACNLEKKQKKFDQLLA 1451
Query: 602 DKLKNTGSAQLVGLAQENAAVSNTAGQDE----ATAKAVLEPIQSTSLIGTLTRTSDSEV 657
+ + T SA+ A+E A + E + A+A+ E ++ + + L + +E+
Sbjct: 1452 E--EKTISAK---YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 658 PDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAEC-RALSKRLALAEKSKEALTEE 716
D+ S +D + KSVH + RAL +++ + E L +E
Sbjct: 1507 EDLMSSKDDV-------------------GKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Query: 717 MKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEID 764
++ RL+ L K +E L + + L +Q E++
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Score = 48.5 bits (114), Expect = 2e-05
Identities = 55/282 (19%), Positives = 121/282 (42%), Gaps = 37/282 (13%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
+LQG+ ++ ++ +L Q + ++ + DE+ + K + L+ L+ +DS
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 65 RNLQLAKRVELLQ-----------------DELALSEPRGKKNKKSGESSSQLSQEQKSV 107
+ K++ LQ +E+ +K KS E+ QE+ +
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 108 FDEDLQKKIEENERLHIQFFEAD-------EQHKHVEAELRSRLATLETEAAQHQAVVDG 160
+ ++ +E + L + + E+ + +EA + LE E + + D
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 161 LTRKYMETIEKLQND-------KAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG 213
L + ++ I+++ D K E Q LE++ KE +++ +E + +K+ ++
Sbjct: 1752 LKKANLQ-IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810
Query: 214 RLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDI 255
LE ++ + E++ N+TK Q V RR + K++D+
Sbjct: 1811 ALEAKIAQLEEQLD-NETKERQAACKQV----RRTEKKLKDV 1847
Score = 47.8 bits (112), Expect = 4e-05
Identities = 143/835 (17%), Positives = 311/835 (37%), Gaps = 114/835 (13%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDS-- 61
AELQ + +L + +K + Q V +E A ++++ + + +LQ++++S
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 62 -----LTFRNLQLAKRVELLQDEL--------ALSEPRGKKNKKSGESSSQLSQEQKSVF 108
+ L + +E L+ EL A E R K+ ++ L +E K+
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT-H 1183
Query: 109 DEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMET 168
+ +Q+ +++ + + E EQ K V+A L TLE E + V L + ++
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDS 1243
Query: 169 IEKLQNDKAKLE---VKSQTLEKEAKECRLRTEECQLQLKTL------HEDLSGRLEESL 219
K + +A+L+ VK E+ E + + Q++L + + S +L +
Sbjct: 1244 EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF 1303
Query: 220 SIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQ 279
S + ++ + N + L K++ + + +F + L H +Q
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLST-----KLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358
Query: 280 ----RIQIFPVDSAI-DTISPLN--QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTV 332
Q+ + + D++ L ++ + L ++ + E + ++ + + +
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418
Query: 333 LETTVKLKTFSEHLTSYICFLRKILPY--QLKSLEEECESSLCTSALRARNLELSQDMKK 390
+ L +H C L K QL + E+ + RA ++ K
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 391 MT---AVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQ 447
++ A+ E ++ L L RT ++++ H++ K Q
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQ-----FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 448 KAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASG 507
++ +L +L T D L V L + + F +L K
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQ----AMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 508 FISPLSAECMLQYKKK--AAAYMKSLRKPLLESVPY--------EEALANRRILLSSTE- 556
+ + AE + K++ A A K L L + + +EA+ R L + +
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 557 ----------SREGLAQQVQQSLEKISKLEQEK---EHWMLEAQLAKIKLEKENQRIADK 603
SRE + Q +++ +K+ +E E + + A+ AK + ++E +AD+
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 604 LKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESR 663
+ N+ + L ++ + A +E E +T LI + ++ ++ + +
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELE----EEQGNTELINDRLKKANLQIDQINTD 1765
Query: 664 EDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQN 723
+L ++H +++ A + E +E+K+
Sbjct: 1766 LNLERSH-----------------------------AQKNENARQQLERQNKELKV---- 1792
Query: 724 ISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNK 778
+LQ+ T K Y+ ++ + + + E L + +E + KK K
Sbjct: 1793 --KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Score = 40.8 bits (94), Expect = 0.005
Identities = 74/313 (23%), Positives = 124/313 (39%), Gaps = 53/313 (16%)
Query: 512 LSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEK 571
L + LQ + + A + LR L E + + L + E E Q +Q +K
Sbjct: 883 LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD--LEARVEEEEERCQHLQAEKKK 940
Query: 572 ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLV------GLAQENAAVSNT 625
+ + QE E + E + A+ KL+ E KLK Q++ LA+E + +
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 626 AGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVE--------SREDLIKN-------- 669
E T E +S SL L ++ + D+E R++L K
Sbjct: 1001 IA--EFTTNLTEEEEKSKSL-AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 670 --------HYMARIVELTSQLQLADSKSVHFYA--ECRALSKRLALAE-KSKEALTEEMK 718
A+I EL QL + + A E A K +AL + + E+ E++
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 719 --LASQNISR---------LQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK 767
L S+ SR L +EL K ED L D + E SK+ +E++ LK
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTL----DSTAAQQELRSKREQEVNILK 1173
Query: 768 MSSKGNSKKNKSR 780
+ + +K ++++
Sbjct: 1174 KTLEEEAKTHEAQ 1186
Score = 36.6 bits (83), Expect = 0.092
Identities = 43/225 (19%), Positives = 94/225 (41%), Gaps = 19/225 (8%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD--- 60
A GK +E +L A+ L++ + +EQ N+ + ++LK + + ++ +++
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770
Query: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQK-SVFDEDLQKKIEEN 119
S +N +++E EL + + KS +S + E K + +E L + +E
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 120 ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 179
+ A +Q + E +L+ L ++ E +Y + +K +L
Sbjct: 1831 Q-------AACKQVRRTEKKLKDVLLQVDDERRN--------AEQYKDQADKASTRLKQL 1875
Query: 180 EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINE 224
+ + + E+EA+ + Q +L+ E E S+ N+
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.9 bits (159), Expect = 1e-10
Identities = 162/820 (19%), Positives = 329/820 (40%), Gaps = 100/820 (12%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL- 62
A+L+ + +++ + +LR Q + ++ +E + + ++ +++ RKL+ EMD
Sbjct: 385 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT---EEARRKLKAEMDEQI 441
Query: 63 -TFRNLQLAKRVELLQDELALSEPRGKKNKKSGESS----SQLSQEQKSVFDEDLQKKIE 117
T +R+ L Q+ + + KKS E +L +++ + +++L KK++
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 501
Query: 118 ENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKA 177
ER E EQ K + +S + E Q +++ +E+L+ K
Sbjct: 502 TRER------EFQEQMKVALEKSQSEYLKISQEKEQQESLA----------LEELELQKK 545
Query: 178 KL----EVKSQTLEKEAKECRLRTEECQLQL-KTLHEDLSGRLEESLSIINEKVPFNDTK 232
+ E K + L++EA+ R R E + L K+L E+ + + ++ + EK N
Sbjct: 546 AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEI 605
Query: 233 YSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAI-- 290
L + +HQ + Q T + EQ + D I
Sbjct: 606 TVMVEKHKTELESLKHQQDAL-WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664
Query: 291 -DTISPLNQKFSQYLHENASYVRPLEEGMLHLFES---ITEDTVTVLETTVKLKTFSEHL 346
I +N+K + L + + L + + ++ + E+ + + T K+K + L
Sbjct: 665 QAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK---QEL 721
Query: 347 TSYICFLRKILPYQLKSLEEECESSL--CTSALRARNLELSQDMKKMTAVFEKLQTYIAL 404
+ + + Q+ S+ +E E S+ AL+ + +L +K+ ++ Q ++
Sbjct: 722 EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN 781
Query: 405 LALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLIT 464
L +G L+ A L F S + Q A E +L QKL+
Sbjct: 782 LEADIKRSEGELQ--------QASAKLDVFQSYQ---SATHEQTKAYEEQLAQLQQKLLD 830
Query: 465 --TNDCILSSVVALTNGAGKIASFF------------------SNNLDYFIASLS--YGP 502
T +L+ VA K ++ ++ + SL+ Y
Sbjct: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 503 KAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLA 562
K G + +L K+ M+ +K +E + + + I + + E
Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFK 950
Query: 563 QQVQQSLEKISKLEQEKEHWM---LEAQLAKIKLEKENQRIADKLKNTG-SAQLVGLAQE 618
Q ++ +EK+ + +E + + L Q AK+K E EN + K +A+++ +AQ
Sbjct: 951 NQ-EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQA 1009
Query: 619 NAA-VSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVE 677
N+A +S+ + E K +E +LT E+ DV S + N + E
Sbjct: 1010 NSAGISDAVSRLETNQKEQIE---------SLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 678 LTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRS 737
+ ++QL + + E L +++ L KE + +E+ + + QD TT
Sbjct: 1061 I-HEIQLQEKEQ-----EVAELKQKILLFGCEKEEMNKEITWLKEEGVK-QD---TTLNE 1110
Query: 738 YEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKN 777
++QL S H+ S+ + +K + ++ L++ + K+N
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150
Score = 58.5 bits (140), Expect = 2e-08
Identities = 147/736 (19%), Positives = 292/736 (39%), Gaps = 112/736 (15%)
Query: 44 QLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQE 103
QL+ K+Q + +L+Q++ ++ K + L++E K++ E QL +
Sbjct: 1065 QLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV------KQDTTLNELQEQL--K 1116
Query: 104 QKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAE-LRSRLATLETEAAQHQAVVDGLT 162
QKS L + E + H++ E D E L+ +L L+ A + + V LT
Sbjct: 1117 QKSAHVNSLAQD-ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 163 RKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSII 222
K T E+ Q+ K+ E +++LE ++ E + +EE +QL + LE
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK---T 1232
Query: 223 NEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQ 282
NE + + +K + L+ H + K+++ L+ T +E Q
Sbjct: 1233 NELINISSSKTNA--ILSRISHCQHRTTKVKE-------------ALLIKTCTVSELEAQ 1277
Query: 283 IFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTF 342
+ + +T++ Q+ + L E + ++ ++ + L +TE E + +
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL---VTEKEALQKEGGNQQQAA 1334
Query: 343 SEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYI 402
SE S I L+K L + ++ +L L+ + +E+S K++T + +LQ I
Sbjct: 1335 SEK-ESCITQLKKELSENINAV------TLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 403 ALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKL 462
+L +E + + + K Y ++ EL Q L
Sbjct: 1388 SL-----SEKEA----------------------AISSLRKQYDEEKC---ELLDQVQDL 1417
Query: 463 ITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYK- 521
D + ++ ++ FS + KA S F + LQ +
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFS----------EWKKKAQSRFTQHQNTVKELQIQL 1467
Query: 522 --KKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEK 579
K AY K + LL+ E N+R + L +++ K+ K E
Sbjct: 1468 ELKSKEAYEKDEQINLLKE---ELDQQNKRF--------DCLKGEMEDDKSKMEKKESNL 1516
Query: 580 EHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEP 639
E L++Q A+I +L++ + + + + N + N Q + K +++
Sbjct: 1517 E-TELKSQTARIM----------ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 640 IQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYA---EC 696
+Q +G D+ V + E + ++N + EL ++ + + ++ + E
Sbjct: 1566 LQHFQELG---EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622
Query: 697 RALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD-HLCSMNET 755
+AL R L +S L E + A Q I+ ++ +L + E+Q ++ HL +N
Sbjct: 1623 KALEDR--LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
Query: 756 LSKQREEIDTLKMSSK 771
L ++ E+ L+ K
Sbjct: 1681 LQEREREVHILEEKLK 1696
Score = 58.5 bits (140), Expect = 2e-08
Identities = 146/790 (18%), Positives = 320/790 (40%), Gaps = 103/790 (13%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMK-DQSLRKLQQEMDSL 62
+EL K + +E+ L++ ++ K + D+ L E+L ++ D +K + +++
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231
Query: 63 TFRNLQLAK-RVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENER 121
T + ++ + + ++ + R K K++ + S + L++ EE
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEA----LLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 122 LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK---LQNDKAK 178
L+I F +A Q + E +++S A +E+ + +A+ + EK + K +
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 179 LE--VKSQTLEKEA-KECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQ 235
L + + TL KE KE ++ QL DL+ +L+ S+S+ ++ + + Q
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLT----DLNVQLQNSISLSEKEAAISSLR-KQ 1402
Query: 236 YNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISP 295
Y+ L ++ VQDL T ++++I SA++ +
Sbjct: 1403 YDEEKCELLDQ----------------VQDLS---FKVDTLSKEKI------SALEQVDD 1437
Query: 296 LNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL---TSYICF 352
+ KFS++ + S T+ TV E ++L+ S+ I
Sbjct: 1438 WSNKFSEWKKKAQS--------------RFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 353 LRKILPYQLKS---LEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPS 409
L++ L Q K L+ E E + NLE ++K TA +L+ +I +
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET--ELKSQTARIMELEDHITQKTI-- 1539
Query: 410 TEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAI-EHELPTATQKLITTNDC 468
E + L + VL N H + +H+ + ++ + A +K++T +
Sbjct: 1540 -EIESL-----NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQ 1593
Query: 469 ILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYM 528
+ S L ++ +++ + S KA + SA + + K+KA +
Sbjct: 1594 VYSMKAELETKKKEL-----EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKI 1648
Query: 529 KSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQL 588
+++K LL + +E + ++G + + K+ E+E+E +LE +L
Sbjct: 1649 AAIKKQLLSQMEEKEE-----------QYKKGTESHLSELNTKLQ--EREREVHILEEKL 1695
Query: 589 AKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGT 648
++ + I + + + ++ A S Q K + T
Sbjct: 1696 KSVESSQSETLIVPR----SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 649 LTRTSDSEVPDVESREDLIKNHYMARIVELT-SQLQLADSKSV--HFYAECRALSKRLAL 705
L R + V S ++ + Y R+++L ++ + + +S+ H E +K+ +L
Sbjct: 1752 LQRVGQEKEETVSSHFEM-RCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Query: 706 --AEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQRE-- 761
A+ ++ + A QN+ + D++ T + E ++ + ++ L +Q+E
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 762 EIDTLKMSSK 771
++ +++SK
Sbjct: 1871 RVEMEELTSK 1880
Score = 56.2 bits (134), Expect = 1e-07
Identities = 151/836 (18%), Positives = 330/836 (39%), Gaps = 89/836 (10%)
Query: 7 QGKYQKLAQEYSKLRAQNQVLKKGVVDEQANS----AALKEQLKMKDQSLRKLQQEMDSL 62
+GKY +L Y L+ + + L+ + Q S A L+E+L+M Q+ + LQ+E D+
Sbjct: 154 RGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDAS 213
Query: 63 TFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQ--EQKSVFD----------- 109
Q + +LQ +++L + R + + + L Q Q VF
Sbjct: 214 LEEKDQY---ISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEP 270
Query: 110 -----------EDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVV 158
E LQ++++ E L + E + HK + L T E EA Q Q
Sbjct: 271 VVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKE-----QCTLLTSEKEALQEQ--- 322
Query: 159 DGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEES 218
+ ++ +EK+++ + K T ++AK E+ + + + ++ E+
Sbjct: 323 ---LDERLQELEKIKDLHMAEKTKLITQLRDAKNL---IEQLEQDKGMVIAETKRQMHET 376
Query: 219 LSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMR--DIAGQALAFVQDLVTALLNFHTY 276
L + E++ ++ Q L ++ + + + +AL+ Q A
Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 436
Query: 277 TEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVT--VLE 334
+++I+ S + IS L Q+ S+ E ++ E + + + E + E
Sbjct: 437 MDEQIKTIEKTSEEERIS-LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQE 495
Query: 335 TTVKLKT----FSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALR-ARNLELSQDMK 389
T KL+T F E + + + Y S E+E + SL L + L++
Sbjct: 496 LTKKLQTREREFQEQMK--VALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESEN 553
Query: 390 KMTAVFEKLQTY-IALLALPSTEPDGLLRT-NYSSVLTNVGAALHGFH--DVMKDISKHY 445
K+ + ++ +TY +L L S+ L N S L A H ++ + KH
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK 613
Query: 446 SQKAAIEHELPTA-TQKLITTNDCILSSVVALTNGA----------------GKIASFFS 488
++ +++H+ T+KL + + L I
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 489 NNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANR 548
L+ + +S L A L+ + K LE+ E+ ++
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 549 RILLSSTESREGLAQQVQQSL-EKISKLE---QEKEHWMLEAQLAKIKLEKENQRIADKL 604
+ + S + E Q+ +++L ++I++LE +E++ + E Q LE + +R +L
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL 793
Query: 605 KNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRE 664
+ + V + ++A T +E A+ + + + LT+ +V +VE+++
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK----QVAEVEAQK 849
Query: 665 DLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNI 724
+ A +++ +Q + ++ + ++L++ + E E +E + Q +
Sbjct: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ---VYESKLEDGNKEQEQTKQIL 906
Query: 725 SRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNKSR 780
++ + + + ++ +++ L + +++ EE +T + + +K K +
Sbjct: 907 VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Score = 52.8 bits (125), Expect = 1e-06
Identities = 143/790 (18%), Positives = 310/790 (39%), Gaps = 101/790 (12%)
Query: 41 LKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDEL--ALSEPRGKKNKKSGESSS 98
L++++K ++ L++ ++ + S + L E LQ++L L E K+ E +
Sbjct: 284 LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTK 343
Query: 99 QLSQ--EQKSVFDEDLQKK---IEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQ 153
++Q + K++ ++ Q K I E +R Q E E + A+LRSR+ + T+ +
Sbjct: 344 LITQLRDAKNLIEQLEQDKGMVIAETKR---QMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 154 HQAVVDGLTRKYMETIEKLQND-----------KAKLEVKSQTLEKEAKECRL------- 195
+ + R E +EK + KA+++ + +T+EK ++E R+
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 196 ------------RTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPL 243
+EE +L+ LHE R E+ L+ +K+ + ++ + + +
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELT---KKLQTREREFQEQMKVALEK 517
Query: 244 HNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAI--DTISPLNQKFS 301
+ ++ Q +++L T +E +++ ++ I L
Sbjct: 518 SQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE 577
Query: 302 QYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL--------TSYICFL 353
+ L EN + + L +HL + + K KT E L T + L
Sbjct: 578 KSLQENKNQSKDL---AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634
Query: 354 RKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPD 413
++ +++ L E+CE T L+ + + +++M + + L + TE +
Sbjct: 635 KQQYQTEMEKLREKCEQEKET-LLKDKEIIFQAHIEEMN------EKTLEKLDVKQTELE 687
Query: 414 GLLRTNYSSVLTNVGAALHGFHD---VMKDISKHYSQKAAIEHELPTATQKLITTNDCIL 470
L SS L+ V A H + V+KD + Q+ +E ++ D I+
Sbjct: 688 SL-----SSELSEVLKARHKLEEELSVLKDQTDKMKQE--LEAKMDEQKNHHQQQVDSII 740
Query: 471 SSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC------MLQYKKKA 524
K N L+ + K + L A+ + Q K
Sbjct: 741 KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800
Query: 525 AAYMKSLRKPLLESVPYEEALAN-RRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWM 583
+ ++ YEE LA ++ LL R L +QV + + + E +
Sbjct: 801 DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 584 LEAQLAKIKLEKENQRIADKLKN---------------TGSAQLVGLAQENAAVSNTAGQ 628
++ Q +LEK+N + K+K+ + + + +EN + GQ
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 920
Query: 629 DEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSK 688
+ + I L +++ + E + + +K A+ ++ T + +L D +
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ--KAKEMQETLKKKLLDQE 978
Query: 689 SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSD- 747
+ + + L L++K K+ + +++A N + + D ++ + + ++Q+ +++
Sbjct: 979 A---KLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
Query: 748 HLCSMNETLS 757
H +N+ +S
Sbjct: 1036 HRRELNDVIS 1045
Score = 38.1 bits (87), Expect = 0.032
Identities = 39/175 (22%), Positives = 77/175 (44%), Gaps = 7/175 (4%)
Query: 7 QGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQ-LKMKDQSLRKLQQEMDSLTFR 65
Q + +K+ QE L ++ K ++ E A KEQ L+M + QE+++
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE 2032
Query: 66 NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQ 125
+ Q + L ++A + K+ K E +E+ + DLQ ++EE ++ + Q
Sbjct: 2033 SHQ--EETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
Query: 126 FFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLE 180
E +E + + L+T+ AQ ++ K E E++ N + +L+
Sbjct: 2091 KLEQEENPGNDNVTIME----LQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
Score = 35.0 bits (79), Expect = 0.27
Identities = 59/305 (19%), Positives = 126/305 (41%), Gaps = 37/305 (12%)
Query: 489 NNLDYFIASLSYGPKAAS--------GFISPLSAECMLQYKKKAAAYMKSLRKPLLESVP 540
N LD ++ S+ P + G L+ E ++Q ++ + S R E V
Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162
Query: 541 YEEALANRRILLSS--TESREGLAQQVQQSLEKISKLEQEKEHWMLE-----------AQ 587
+ L + L ++S++ +++ + E++ +Q K+H E
Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYIS 222
Query: 588 LAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIG 647
+ + ++ QR+ + N + + + A V E+ + V+E S +
Sbjct: 223 VLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLE 282
Query: 648 TLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAE 707
TL + + ++ ++ I++H + LTS+ + + L +RL E
Sbjct: 283 TLQQRVKRQENLLKRCKETIQSH-KEQCTLLTSEKEALQEQ----------LDERLQELE 331
Query: 708 KSKEA-LTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 766
K K+ + E+ KL I++L+D ++ +D+ ++++ M+ETL + EEI L
Sbjct: 332 KIKDLHMAEKTKL----ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQL 387
Query: 767 KMSSK 771
+ K
Sbjct: 388 RSRIK 392
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 65.5 bits (158), Expect = 2e-10
Identities = 155/777 (19%), Positives = 301/777 (38%), Gaps = 79/777 (10%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
Q+L + KL + L+ + + QA LK QL K++ L+ D T
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 71 KRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQK-KIEENERLHIQFFEA 129
K V LQ ++A + ++ +S ++S +++QK E+L+ K E + L +
Sbjct: 1111 KVVRELQAQIAELQ----EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 130 DEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQND-------KAKLEVK 182
+ + K E E+ LE E H+A + + +++ +E+L KA LE
Sbjct: 1167 ELRTKR-EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 183 SQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVP 242
Q LE + KE + Q Q+K E +L+ + ++ KV D +
Sbjct: 1226 KQGLETDNKELACEVKVLQ-QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284
Query: 243 LHNRRHQLK--MRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
L N + + + + + F +D + E ++Q DT L ++
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAAS--------LESQLQ--------DTQELLQEET 1328
Query: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQ 360
Q L+ +S +R LEE L E E+ E L+ L S + +K +
Sbjct: 1329 RQKLN-LSSRIRQLEEEKNSLQEQQEEEE----EARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 361 LKSLE--EECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL-- 416
L ++E EE + L A LSQ +++ ++KL+ L E D L
Sbjct: 1384 LGTIESLEEAKKKLLKDA-----EALSQRLEEKALAYDKLEKTKNRL---QQELDDLTVD 1435
Query: 417 RTNYSSVLTNVGAALHGFHDVM---KDISKHYS-QKAAIEHELPTATQKLITTNDCILSS 472
+ V +N+ F ++ K IS Y+ ++ E E K ++ + +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 473 VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLR 532
+ A + ++ D + G L+ K+A
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE-----------LEKSKRALEQQVEEM 1544
Query: 533 KPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIK 592
+ LE + +E A L + + + Q ++ L+ + +EK+ +++ Q+ +++
Sbjct: 1545 RTQLEELE-DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK-QVRELE 1602
Query: 593 LEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRT 652
E E++R L ++ + + Q EA KA E I+ + +
Sbjct: 1603 AELEDERKQRALAVASKKKM------EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 653 SDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEA 712
E+ + + D I A+ E +L+ +++ + E + + AE+ ++
Sbjct: 1657 YQRELEEARASRDEI----FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 713 LTEEMKLASQNISRLQDE---LTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 766
L +E+ ++ S L DE L E++L ++ +N+ K ++DTL
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL 1769
Score = 56.6 bits (135), Expect = 9e-08
Identities = 159/785 (20%), Positives = 305/785 (38%), Gaps = 99/785 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQV---LKKGVVDEQANSAALKEQLK--MKDQSLRKLQQEM 59
E++ K+Q+L +E + L Q Q L + +A AA K++L+ + D R ++E
Sbjct: 877 EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEE 936
Query: 60 DSLTFRNLQLAKRVELLQDELALSEPRGKKNKK-----SGESSSQLSQEQKSVFDEDLQK 114
+ +N + + + E L E G + K + E+ + +E+ + ++ K
Sbjct: 937 RNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996
Query: 115 KIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQN 174
I+E + + + E Q E E LA + + + ++ +K +T ++L+
Sbjct: 997 FIKEKKLMEDRIAECSSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 175 DKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYS 234
K KL+ ++ L+ + E + + +E +LQL E+L G L +D
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG----------DDETLH 1105
Query: 235 QYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQI--------FPV 286
+ NAL V +R++ Q +D + + + +Q+ + +
Sbjct: 1106 KNNALKV----------VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL 1155
Query: 287 DSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL 346
+ +DT + + ++ E A + LEE + E+ +D T L+ SE L
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETKN-HEAQIQDMRQRHATA--LEELSEQL 1212
Query: 347 TSYICFLRKILPYQLKSLEEECESSLC-TSALRARNLELSQDMKKMTAVFEKLQTYIA-- 403
F + L + LE + + C L+ E KK+ A ++L ++
Sbjct: 1213 EQAKRF-KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEG 1271
Query: 404 -LLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKL 462
L + E L+ +V T + A KD + SQ + L T++
Sbjct: 1272 DRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQK 1331
Query: 463 ITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKK 522
+ + I L+ SL + L + +L +
Sbjct: 1332 LNLSSRI-------------------RQLEEEKNSLQEQQEEEEEARKNLEKQ-VLALQS 1371
Query: 523 KAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHW 582
+ A K + L EEA ++ LL E+ L+Q++++ KLE+ K
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEA---KKKLLKDAEA---LSQRLEEKALAYDKLEKTKNR- 1424
Query: 583 MLEAQLAKIKLEKENQR-IADKLKNTGSAQLVGLAQENAAVSNTAGQ-DEATAKAVLEPI 640
L+ +L + ++ ++QR +A L+ LA+E + + A + D A A+A +
Sbjct: 1425 -LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 641 QSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALS 700
++ SL L +E++E+ + + R L SK +
Sbjct: 1484 KALSLARALEEA-------LEAKEEFERQNKQLR----ADMEDLMSSKD--------DVG 1524
Query: 701 KRLALAEKSKEALTEEMKLASQNISRLQDELTTT---KRSYEDQLSMMSDHLCSMNETLS 757
K + EKSK AL ++++ + L+DEL T K E + M +T
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584
Query: 758 KQREE 762
+Q EE
Sbjct: 1585 EQNEE 1589
Score = 49.3 bits (116), Expect = 1e-05
Identities = 145/834 (17%), Positives = 315/834 (37%), Gaps = 106/834 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
ELQ + +L +++ +A +K D ALK +L + +L + + T
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL---EDTLDTTAAQQELRTK 1171
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
R ++A+ + L++E K+ E+ Q +++ + E+L +++E+ +R
Sbjct: 1172 REQEVAELKKALEEET-----------KNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 125 QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKL-QNDKAKLEV-- 181
+ + + EL + L+ A+ + L + E K+ + D+ ++E+
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 182 KSQTLEKEAKECRLRTEECQLQLKTLHED---LSGRLEESLSIINEKVPFNDTKYSQYNA 238
K+ L+ E EE + + +D L +L+++ ++ E+ S+
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 239 LNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQ 298
L ++ + Q + + A + L + V AL + T+++ VD + TI L +
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKK-----VDDDLGTIESLEE 1392
Query: 299 K----------FSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTS 348
SQ L E A LE+ L + + + TV + +
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 349 YICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALP 408
+ L + + EE + + L L++ +++ E+ +
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE--------- 1503
Query: 409 STEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDC 468
+ LR + ++++ H++ K Q + +L +L T D
Sbjct: 1504 --RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 469 ILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAY- 527
L V + + + F +L + + L AE + K++A A
Sbjct: 1562 KLRLEVNMQ----AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 528 --------------------------MKSLRKPLLESVPYEEALANRRILLSSTESREGL 561
+K LRK + Y+ L R SR+ +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA------SRDEI 1671
Query: 562 AQQVQQSLEKISKLEQE---KEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQE 618
Q ++S +K+ LE E + + ++ A+ E+E +AD++ N+ S + L ++
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 619 N------AAVSNTAGQDEATAKAVLEPIQSTSL-IGTLTRTSDSEVPDVESREDLIKNHY 671
A + ++++ + + + + T+L + TL +E + D +
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQL 1790
Query: 672 MARIVELTSQLQ-LADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDE 730
+ EL ++LQ L + F A AL ++ E+ E +E A++ + R + +
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 731 L------TTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNK 778
L +R + DQ + + + L +Q EE + + +++ N+ + K
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE--EEATRANASRRK 1902
Score = 48.5 bits (114), Expect = 2e-05
Identities = 139/745 (18%), Positives = 288/745 (38%), Gaps = 99/745 (13%)
Query: 67 LQLAKRVELLQ--DELALSEPRGKKNKKSGESSS-----QLSQEQKSVFDEDLQKKIEEN 119
LQ+ ++ E LQ DE L + + K+ K GE Q E+K++ E LQ + E
Sbjct: 845 LQVTRQEEELQAKDE-ELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE-- 901
Query: 120 ERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL 179
F EA+E +R+RLA + E + ++ + E + LQN+K K+
Sbjct: 902 -----LFAEAEE--------MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 180 EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 239
+ Q LE++ E ++ QL+ T + ++EE + ++ ++ N + +
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK-KMEEEILLLEDQ---NSKFIKEKKLM 1004
Query: 240 NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQK 299
+ QL + + LA +++ +Q + I ++ + Q+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRN------------KQEVMISDLEERLKKEEKTRQE 1052
Query: 300 FSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK-------TFSEHLTSYICF 352
+ + L++ + L I E + + + +L+ + H + +
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 353 LRKILPYQLKSLEEECESSLCT-SALRARNLELSQDMKKM-TAVFEKLQTYIALLALPST 410
+R+ L Q+ L+E+ ES + + + +LS++++ + T + + L T A L +
Sbjct: 1113 VRE-LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK 1171
Query: 411 EPDGL--LRTNYSSVLTNVGAALHGFHD----VMKDISKHYSQKAAIEHELPTATQKLIT 464
+ L+ N A + ++++S+ Q + L Q L T
Sbjct: 1172 REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231
Query: 465 TNDCILSSVVALTNGAGKIASFFSNNLDYFI----ASLSYGPKAASGFISPLS------- 513
N + V L + + LD + A +S G + S
Sbjct: 1232 DNKELACEVKVLQQVKAE-SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 514 --AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEK 571
+ + + +KK + K LES + + +L T + L+ +++Q E+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAAS--LES----QLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 572 ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEA 631
+ L++++E E + A+ LEK+ + +L +T V + G E+
Sbjct: 1345 KNSLQEQQE----EEEEARKNLEKQVLALQSQLADT-----------KKKVDDDLGTIES 1389
Query: 632 TAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADS---- 687
+A + ++ + +E ++ ++ V+L Q Q+A +
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 688 --KSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE---DQL 742
K AE +++S R A EA E + + +++R +E K +E QL
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 743 SMMSDHLCSMNETLSKQREEIDTLK 767
+ L S + + K E++ K
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSK 1534
Score = 38.1 bits (87), Expect = 0.032
Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 7/117 (5%)
Query: 9 KYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQ-------SLRKLQQEMDS 61
K +++ + R K+ + A LK QL+ ++ S RKLQ+E+D
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 62 LTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEE 118
T N L++ V L++ L P + +SG L + D+D + K +
Sbjct: 1910 ATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSD 1966
Score = 35.8 bits (81), Expect = 0.16
Identities = 50/238 (21%), Positives = 94/238 (39%), Gaps = 15/238 (6%)
Query: 28 KKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRG 87
K ++DE+ A QL ++ L + Q M+ L R + +V+ L ELA
Sbjct: 1724 KSALLDEKRRLEARIAQL---EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 88 KKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEAD--EQHKHVEAELRSRLA 145
+K+ + + + ++E K+ E L+ ++ + I EA + + +E E + R A
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQE-LEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 146 T------LETEAAQHQAVVDGLTR---KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLR 196
E + + V+ R +Y E +EK +L+ + + E+EA
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 197 TEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRD 254
+ Q +L E G E ++ N +S + LH L++ D
Sbjct: 1900 RRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSD 1957
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 65.5 bits (158), Expect = 2e-10
Identities = 166/829 (20%), Positives = 323/829 (38%), Gaps = 104/829 (12%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
++L E L +N++L+K + + LK+ + + L+QE L N +L
Sbjct: 628 EELENELHHLEKENELLQKKITN-----------LKITCEKIEALEQENSELERENRKLK 676
Query: 71 KRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQ--------KKIE-ENER 121
K ++ ++ E K+N + E + +L + +S+ ++ K++E E E+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 122 LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEV 181
L K E L L+ E + Q ++ +K I++L+++ LE+
Sbjct: 737 LKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKK----IQQLESELQDLEM 791
Query: 182 KSQTLEKEAKECRL---RTEECQLQLKTLHEDLS------GRLEESLSIINEKVPFNDTK 232
++QTL+K +E ++ R E+ + + K+L ++ S +LE+ + ++ DT
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 233 YSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDT 292
+ NV + N + K + + ++ L ++ ++ +D I T
Sbjct: 852 LEEN---NVKIGNLEKENK---TLSKEIGIYKESCVRLKELEKENKELVKRATID--IKT 903
Query: 293 ISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL----ETTVKLKTFSEHLTS 348
+ L + + LE+ + H E I + +L T + K L S
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEK-LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
Query: 349 YICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKL-QTYIALLAL 407
+ +I ++ +LE E S N +L Q++K + +E L Q +
Sbjct: 963 TLKKSLEIKEEKIAALEARLEES------TNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 408 PSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTND 467
S+ P + L D + ++ ++ + A + L T ++L T N+
Sbjct: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
Query: 468 CILSSVVAL-----------TNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAEC 516
+ + ++AL T + A N S S + A I S E
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
Query: 517 MLQYKKKAAAYMKSLRKPLLESVPYEEALANRRIL-LSSTESREGLAQQVQQSLE-KISK 574
+ K +KSL L++ E L R+ S S+ G + ++LE +
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1196
Query: 575 LEQE-----KEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQD 629
LE K+ LE +K+E+E + +K T +A+ L EN +++T Q
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ- 1255
Query: 630 EATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKS 689
++ T ++ +T + + + L + A +L Q Q D S
Sbjct: 1256 ---------LLKETEVL----QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
Query: 690 VHFYAECRALSK-RLALAEKSKEALTEEMKLASQNISRLQDELTT------TKRSYEDQL 742
+C LS+ + L E+++ L + L QN + L+ + + +R Y D+L
Sbjct: 1303 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Query: 743 SMMSDHLCSMNETLSKQREEID-----------TLKMSSKGNSKKNKSR 780
+ + + E + Q + D TLKM SKK+ +R
Sbjct: 1363 NELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1411
Score = 49.7 bits (117), Expect = 1e-05
Identities = 146/754 (19%), Positives = 296/754 (39%), Gaps = 85/754 (11%)
Query: 41 LKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQL 100
L +L +R+L+QE++ T + L + +E ++ EL + S+
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 101 SQE-----QKSVFDEDLQKKIEE-NERLH-IQFFEADEQHKHVEAELRSRLATLETEAAQ 153
E +K+V + L+ ++ ERLH I+F++A VE LET+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKA-----RVEELKEDNQVLLETKTML 363
Query: 154 HQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG 213
+ TR + + +L+ + +L+ K +E E R + EE + TL
Sbjct: 364 EDQLEG--TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 214 RLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNF 273
++ESL + E + T P + H+ + ++ L ++ +L
Sbjct: 422 SMDESLHLGWELEQISRTS----ELSEAPQKSLGHE--VNELTSSRLLKLEMENQSLTK- 474
Query: 274 HTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 333
T E R + V+ I + +K +Q L + V LE ++ +S+ ++ +
Sbjct: 475 -TVEELRTTVDSVEGNASKILKM-EKENQRLSKK---VEILENEIVQEKQSL-QNCQNLS 528
Query: 334 ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECES-SLCTSALRARNLELSQDMKKMT 392
+ +K K L I LR+ Q+K LE+E E + S+LR R+ ++S + +
Sbjct: 529 KDLMKEKA---QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS-QISAEARVKD 584
Query: 393 AVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIE 452
E + +L + + + + K++ +HY +K
Sbjct: 585 IEKE----------------NKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 453 HELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNN-------------LDYFIASLS 499
EL L N+ + + L KI + N LD F +L+
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF-KNLT 686
Query: 500 YGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 559
+ ++ S L E + + + S++ L+ L N+ + + ++
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ-------LENKELESEKEQLKK 739
Query: 560 GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 619
GL + ++ S +K +LE + +E Q + LE N++I ++L L EN
Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL-----ESELQDLEMEN 793
Query: 620 AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 679
+ + + ++K + + + + T + + +E ++ A I + T
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEIKDTT 851
Query: 680 SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 739
L+ + K + E + LSK + + ++S L E K + + R ++ T E
Sbjct: 852 --LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 740 DQLSMMSDHLCS--MNETLSKQREEIDTLKMSSK 771
D ++S+ L + MN L K E++ + ++ +
Sbjct: 910 D---LVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 49.7 bits (117), Expect = 1e-05
Identities = 134/731 (18%), Positives = 290/731 (39%), Gaps = 113/731 (15%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQA---NSAALKEQLKMKDQSLRKLQQ 57
+ + EL+ + ++L + L+A + ++ V Q + L++ L+ ++ +++L+
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 58 EMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDED----LQ 113
E+ L N L K +E L+ E K+NK + +SQL +++K + E+ Q
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 114 KKIEEN--ERLHIQFFEADEQHKHVEAELR------SRLATLETEAAQ--HQAVVDGLTR 163
+I++ E +++ ++++K + E+ RL LE E + +A +D
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID---- 900
Query: 164 KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQL--------------QLKTLHE 209
++T+ L+ D ++K+Q + + ++ E+ L + K L
Sbjct: 901 --IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
Query: 210 DLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTA 269
L L++SL I EK+ + + + N L Q+L T
Sbjct: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR-------------------QELKTV 999
Query: 270 LLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDT 329
N+ +++ + + + + P++ + +++ E+ R L + L E + +
Sbjct: 1000 KKNYEALKQRQDE----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-VERNN 1054
Query: 330 VTV------LETTVK-LKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNL 382
T+ L+T +K L+T + +L + I L++ Q SL+E+ + L+ +N
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQR----QTVSLQEQ------NTTLQTQNA 1104
Query: 383 ELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDIS 442
+L + + + L A L + + L SV+ + ++KD
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSS----LENENESVIKEREDLKSLYDSLIKD-- 1158
Query: 443 KHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGP 502
+K + HE + + + + L S A K +L+ L
Sbjct: 1159 ---HEKLELLHERQASEYESLISKHGTLKS-------AHKNLEVEHRDLEDRYNQL---- 1204
Query: 503 KAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLA 562
G + L E ML+ +++ K LLE+ +E A + L +
Sbjct: 1205 LKQKGQLEDL--EKMLKVEQE---------KMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
Query: 563 QQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAV 622
Q+ + E + + + + ++L + +LE E ++ ++ + L + +
Sbjct: 1254 SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS-TKLNNQCELL 1312
Query: 623 SNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQL 682
S G E + +L+ IQ+ L + E D+ E + Y+ ++ EL Q
Sbjct: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE---QRQYIDKLNELRRQK 1369
Query: 683 QLADSKSVHFY 693
+ + K + Y
Sbjct: 1370 EKLEEKIMDQY 1380
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/228 (21%), Positives = 112/228 (49%), Gaps = 28/228 (12%)
Query: 32 VDEQANSAALKEQLKMKDQSLRKLQQEMDS--------------LTFRNLQLAKRVELLQ 77
V+E +S LK L+M++QSL K +E+ + + N +L+K+VE+L+
Sbjct: 454 VNELTSSRLLK--LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 78 DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVE 137
+E+ + K++ ++ ++ S+ ++K+ ++ ++ E +ER I+ E + +H +
Sbjct: 512 NEIV----QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQT 566
Query: 138 AELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEA---KECR 194
+ + + EA ++ + E+I++ + +K+E + + ++KE KE
Sbjct: 567 VSSLRQRSQISAEARVKD--IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624
Query: 195 LRTEECQLQLKTLHE--DLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
R EE + +L L + +L + +L I EK+ + + S+ N
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672
Score = 39.3 bits (90), Expect = 0.014
Identities = 57/242 (23%), Positives = 99/242 (40%), Gaps = 44/242 (18%)
Query: 555 TESREGLAQQVQQSLEK-ISKLEQEKEHWMLEAQLAKI-KLEKENQRIADKLKNTGSAQL 612
T SR + QSL K + +L + +E +KI K+EKENQR++ K++ +
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDS--VEGNASKILKMEKENQRLSKKVEILENE-- 513
Query: 613 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 672
+ QE ++ N + K E Q I TL S+ ++ +E + H
Sbjct: 514 --IVQEKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENSERQIKILEQENE----HLN 564
Query: 673 ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 732
+ L + Q++ AE R EK + L E +K S +S+++ E
Sbjct: 565 QTVSSLRQRSQIS--------AEARVKD-----IEKENKILHESIKETSSKLSKIEFEKR 611
Query: 733 TTKRSYE---------DQLSMMSDHLCSMNETLSKQ-------REEIDTLKMSSKGNSKK 776
K+ E ++L HL NE L K+ E+I+ L+ + ++
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 777 NK 778
N+
Sbjct: 672 NR 673
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 65.5 bits (158), Expect = 2e-10
Identities = 157/810 (19%), Positives = 310/810 (38%), Gaps = 103/810 (12%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKL-----QQEMDSLTFR 65
QKL ++L +NQ L + ++ ++ + L+E+ + S + + Q+++D +
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 66 NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLS---QEQKSVFDEDLQKKIEENERL 122
+ A L + + LSE +G+ +K E S++ Q K+ F + LQ++ EE E+
Sbjct: 351 SRLSASETSLHRIHVELSE-KGEATQKLKEELSEVETKYQHLKAEF-KQLQQQREEKEQH 408
Query: 123 HIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVK 182
+Q Q L S+L E + + + + E + + A L++K
Sbjct: 409 GLQLQSEINQ-------LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461
Query: 183 SQTLEKEAKECRLRTEECQLQL----------KTLHEDLSGRLEES---LSIINEKVPFN 229
LE++ KE + E Q QL + L + + +L E+ L + ++
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 230 DTKYSQYNAL------NVP-LHNRRHQLKMRDIAGQALAFVQDLVTALLN-----FHTYT 277
D K AL N+ L R L + AG+ TA+LN HT
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG-------ETAVLNQLQEKNHTLQ 574
Query: 278 EQRIQIF-PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETT 336
EQ Q+ + + ++ + + E +++R ++ +L L S+ E + E+
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
Query: 337 VKLKTFSEHL---TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTA 393
K+ + T + Q L+ +++ +AL+ + EL++ ++
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA--QNALQDKQQELNKITTQLDQ 692
Query: 394 VFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEH 453
V KLQ + + S L +K+ + Y
Sbjct: 693 VTAKLQD----------------KQEHCSQL----------ESHLKEYKEKYLSLEQKTE 726
Query: 454 ELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLS 513
EL +KL + + +S + + +L+ LS + +S S
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQ-LNTDLELRATELSKQLEMEKEIVS--S 783
Query: 514 AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTE--SREGLAQQVQQSLEK 571
LQ K +A ++S+++ L + ++ L LS E L ++Q ++ +
Sbjct: 784 TRLDLQKKSEA---LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Query: 572 ISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEA 631
+ K++ EKE M E K KL K ++D LKN+ S +EN E
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSK----VSDSLKNSKSE----FEKENQKGKAAILDLEK 892
Query: 632 TAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRE-----DLIKNHYMARIVELTSQLQLAD 686
T K + +Q + TL + + + +E L N ++++ + L+ +
Sbjct: 893 TCKELKHQLQ-VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 951
Query: 687 SKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMS 746
+ L + +K EAL E+K+A + L+++L +L+
Sbjct: 952 KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEK 1011
Query: 747 DHLCSMNETLSKQREEIDTLKMSSKGNSKK 776
+ + + K +E L+ G +
Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Score = 52.4 bits (124), Expect = 2e-06
Identities = 55/254 (21%), Positives = 115/254 (45%), Gaps = 25/254 (9%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMD--- 60
++L+ ++ ++Y L + + L+ + +A+S +K K+Q+L+ LQQ+
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS---KEQALQDLQQQRQLNT 761
Query: 61 SLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKI---E 117
L R +L+K++E+ +K SS++L ++KS E +++K+ E
Sbjct: 762 DLELRATELSKQLEM---------------EKEIVSSTRLDLQKKSEALESIKQKLTKQE 806
Query: 118 ENERLHIQFFEADEQHKHVE-AELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDK 176
E +++ Q FE Q ++ EL +R+ T TE + + + L + +KL
Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866
Query: 177 AKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQY 236
L+ EKE ++ + + + K L L ++E +L E + +
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEAS 926
Query: 237 NALNVPLHNRRHQL 250
+ L + L++ + QL
Sbjct: 927 HQLKLELNSMQEQL 940
Score = 49.3 bits (116), Expect = 1e-05
Identities = 162/837 (19%), Positives = 331/837 (39%), Gaps = 86/837 (10%)
Query: 20 LRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL---TFRNLQ-LAKRVEL 75
LR + Q L+ + +E+ S LK++L+ K Q L++ + + D L + LQ L +++E
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELE-KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE 146
Query: 76 LQDE-LALSEPRGKKNKKSGESSSQLSQEQKSVFDED--LQKKIEEN-ERLHIQFFEADE 131
Q E + + + +K+ + +++++ + KS +DE+ L++ E+ RL + +
Sbjct: 147 AQTENFNIKQMKDLFEQKAAQLATEIA-DIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 132 QHKHVEAELRSR-----LATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTL 186
+ ++ EL R +A L+ E Q Q ++D +T + EKL+++ KL+ SQ
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ--SQYA 263
Query: 187 EKEAKECRLRTE------ECQLQLKTLHEDLS--GRLEESLSIINEKVPFNDTKYS---- 234
EA +LR+E E + ++ L + S L + + E + + Y+
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 235 QYNALNVPLHNRRHQLKMRDIAGQAL-AFVQDLVTALLNFHTYTEQ--------RIQIFP 285
++N +V N + L +D+ Q L + + T+L H + + ++
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
Query: 286 VDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
V++ + ++ Q E + L+ + L + E + E +LK
Sbjct: 384 VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE-QRQ 442
Query: 346 LTSYICFLRK----ILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTY 401
L+S ++ L +L LEE+ + + S L+ ++ + + Q+
Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ--QST 500
Query: 402 IALLALPSTEPDGLLRT--NYSSVLTNVGAALHGFHDVMKDISKH----YSQKAAIEHEL 455
A L + + +LR + + N+ A L + + + K Y++ A E E
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 456 PTATQKLITTNDCILSSVVALT---NGAGKIASFFSNNLDYFIASLSYGPKAASGFISPL 512
Q L N + V LT + NL + +AA + L
Sbjct: 561 AVLNQ-LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 619
Query: 513 SA-----ECMLQYKKKAAAYMKSLRKPLLESVPYEEA--LANRRILLSSTESREGLAQQV 565
L K+ + + K E + EA A R L + ++ + Q
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 566 QQSLEKI--------SKLEQEKEHW-MLEAQLAKIK-----LEKENQRIADKLKNTGSAQ 611
QQ L KI +KL+ ++EH LE+ L + K LE++ + + ++K +
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 612 LVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRED------ 665
L A + A+ + Q + L + + + S D++ + +
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 666 --LIKNHYMARIVELTSQLQLADSKSVHFYAECRALS--KRLALAEKSKEALTEEMKLAS 721
L K +I++ + ++K H R + L + KEAL E+
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 722 QNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKKNK 778
+S++ D L +K +E + + + +T + + ++ ++ K+ K
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Score = 43.1 bits (100), Expect = 0.001
Identities = 40/194 (20%), Positives = 85/194 (43%), Gaps = 7/194 (3%)
Query: 13 LAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKR 72
L S+ +NQ K ++D + LK QL+++ ++ K Q+E+ + + + +
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 73 VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQ 132
++L + + + + K E Q Q + + ++K ++ E L + A Q
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 133 HKHVEAELRSRLATLETEAAQHQAVVDGLTRKY---METIEKLQND----KAKLEVKSQT 185
+E +L+ +L E A + + L Y ET ++LQ+D +++L Q
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 186 LEKEAKECRLRTEE 199
L+ ++ L E+
Sbjct: 1049 LKSVEEKLSLAQED 1062
Score = 42.0 bits (97), Expect = 0.002
Identities = 47/200 (23%), Positives = 90/200 (45%), Gaps = 20/200 (10%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
L+ Q L Q+ +L+ + LK V E+ N LK+Q+K +++ L+K F
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK--------EFI 1212
Query: 66 NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQ 125
+ E+ + E+ + KK E+ ++L+ Q + +E+L +E + +
Sbjct: 1213 EKEAKLHSEIKEKEVGM--------KKHEENEAKLTM-QITALNENLGTVKKEWQSSQRR 1263
Query: 126 FFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQT 185
E ++Q + E+ AT++ + +A+++ + E IEKLQ +L+ K
Sbjct: 1264 VSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE-IEKLQTKVLELQRKLDN 1322
Query: 186 LEKEAKECRLRTEECQLQLK 205
+E L E LQ+K
Sbjct: 1323 TTAAVQE--LGRENQSLQIK 1340
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 63.9 bits (154), Expect = 5e-10
Identities = 153/813 (18%), Positives = 334/813 (41%), Gaps = 81/813 (9%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVD-----EQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
+K E + R + + + KG ++ E A L++ L + KLQ+E++
Sbjct: 434 EKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493
Query: 66 NLQLAKRVELLQDELALS-------EPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEE 118
+ R+ L+ +LAL R + NK +G+ LS Q+ LQ+K+E
Sbjct: 494 TVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI---SSLQEKLEV 550
Query: 119 NERLHIQFFEADEQH-----KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ 173
H + + ++H + + E+++ E + +++++ L E + +
Sbjct: 551 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
Query: 174 NDKAKLEVKSQTLEKEAKECR------LRTEECQL-QLKTLHEDLSGRLEESLSIINEKV 226
K+KLE + ++ +E + L TE + +LKT E + RL+ I N +
Sbjct: 611 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM--RLDYQHEIENLQN 668
Query: 227 PFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQAL------AFVQDLVTALLNFHTYTEQR 280
+ + + + +K ++ + +A+ A Q LV + E
Sbjct: 669 QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE 728
Query: 281 IQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK 340
I++ ++ + + ++ + S ++ EE +L L +++ + + KL+
Sbjct: 729 IKV----KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-DALRKASSEGKSEMKKLR 783
Query: 341 TFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELS---QDMKKMTAVFEK 397
E I L +++ E ++S T L+ R L+L+ +++ +++ V E
Sbjct: 784 QQLEAAEKQIKHL------EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
Query: 398 LQTYIALL----ALPSTEPDGLLRTNYSSV---------LTNVGAALHGFHDVMKDISKH 444
L+ + +L A S E + R+ +V + + L + + D+
Sbjct: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
Query: 445 YSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNL---DYFIASLSYG 501
+ +K E +L A +KL ND ++ ++ ++ + ++ L + + L
Sbjct: 898 FREKDEREEQLIKAKEKL--END--IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953
Query: 502 PKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGL 561
A+ S L K + ++ +K E E L++ L E+
Sbjct: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD---LEKKMETSHNQ 1010
Query: 562 AQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAA 621
Q+++ E+ + E + +H + L K L+ E++ + +N+G Q + ++ A
Sbjct: 1011 CQELKARYERATS-ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1069
Query: 622 VSNTAGQDEATAKAVLEPI--QSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 679
+ A Q A ++E + + T + +L T + +++ D +K + + + EL
Sbjct: 1070 KAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA-KLQNELDTLKENNLKNVEELN 1127
Query: 680 SQ---LQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKR 736
L + + K F E L + A + AL EE ++ + R +DE+T+ ++
Sbjct: 1128 KSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK 1187
Query: 737 SYEDQLSMMSDHLCSMNETLSKQREEIDTLKMS 769
E++ S++++ L M + SK ++ D K S
Sbjct: 1188 -LEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1219
Score = 62.0 bits (149), Expect = 2e-09
Identities = 86/416 (20%), Positives = 186/416 (44%), Gaps = 35/416 (8%)
Query: 2 ASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDS 61
AS+E + + +KL Q+ Q + L+ E + ++++ +L+ ++ L LQ+ +
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 62 LTFRNLQLAKRVELLQDELA-LSEPRGKKNKKSGESSSQLSQ--EQKSVFDEDLQKKIEE 118
++ L K +++L+++ A SE + E+ ++L Q EQ ++ DL+K E
Sbjct: 831 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 890
Query: 119 NERLHIQFFEADEQHKHV-------EAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 171
+ +F E DE+ + + E ++ + ++Q + D L K + +E+
Sbjct: 891 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD-VEE 949
Query: 172 LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDT 231
LQ K + L+K ++ ++ E+ Q + HE+ LE LS + +K+ +T
Sbjct: 950 LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM---ET 1006
Query: 232 KYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID 291
++Q L R++ + + +Q+L LL+ TE +++ A +
Sbjct: 1007 SHNQCQELKA-----RYERATSETKTKHEEILQNLQKTLLD----TEDKLK-----GARE 1052
Query: 292 TISPLNQKFSQYLHENASYVRPLE--EGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 349
S L Q+ + L + A + + E + + E +T++ L + K + L +
Sbjct: 1053 ENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111
Query: 350 ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM-TAVFEKLQTYIAL 404
+ L++ LK++EE +S + + E ++++ + A +K Q AL
Sbjct: 1112 LDTLKE---NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1164
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/241 (23%), Positives = 115/241 (47%), Gaps = 13/241 (5%)
Query: 15 QEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVE 74
Q +KL+ + LK+ + KE L +++Q + + ++E+++L Q ++++
Sbjct: 1103 QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1162
Query: 75 LLQDE-LALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
LQ+E + L+E G+ + +S Q +E++SV + L +E +R +ADE+
Sbjct: 1163 ALQEENVKLAEELGRSRDEV--TSHQKLEEERSVLNNQL---LEMKKRESKFIKDADEE- 1216
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAK-LEVKSQTLEKEAKE 192
+A L+ ++ + A ++ L + T+ + +N AK L QTLE + +
Sbjct: 1217 ---KASLQKSISITSALLTEKDAELEKLRNEV--TVLRGENASAKSLHSVVQTLESDKVK 1271
Query: 193 CRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKM 252
L+ + +LQLK LS + + +E +++ N++ V L + LKM
Sbjct: 1272 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1331
Query: 253 R 253
+
Sbjct: 1332 K 1332
Score = 51.6 bits (122), Expect = 3e-06
Identities = 169/854 (19%), Positives = 330/854 (38%), Gaps = 154/854 (18%)
Query: 36 ANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKN----- 90
+ + AL+E LK K Q + +L E D + V ++ ELAL+ ++
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELE 407
Query: 91 --------------KKSGESSSQLSQEQKSVFDEDLQKKIEEN----------------- 119
++ E +QL +E++ V EDLQ ++EE
Sbjct: 408 AKMDQLRTMVEAADREKVELLNQLEEEKRKV--EDLQFRVEEESITKGDLETQTKLEHAR 465
Query: 120 -----ERLHIQFFEADEQHKHVE------AELRSRLATLETEAAQHQAVVDGLTRKY--- 165
+ L + +AD+ + +E +SR+ LE + A V L R+
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 525
Query: 166 ---------METIEKLQNDKAKLEVKSQTLEKEAKECR----LRTEECQLQLKTLHEDLS 212
+ ++++ + + KLEV ++E + R E Q ++K L+
Sbjct: 526 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT--- 582
Query: 213 GRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR-------HQLKMRDIAGQALAFVQD 265
E LS NE + ++ N+ + L + HQ M ++ ++F +
Sbjct: 583 --ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK---VSFSKG 637
Query: 266 LVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESI 325
L T F Q I+ +D + + NQ+ S E A++ + +E L + I
Sbjct: 638 LGTETAEFAELKTQ-IEKMRLDYQHEIENLQNQQDS----ERAAHAKEMEALRAKLMKVI 692
Query: 326 TEDTVTVLETTVKL-KTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTS--------- 375
E ++ KL K +HL L K+ ++K E E + C
Sbjct: 693 KEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT 752
Query: 376 --------------ALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYS 421
ALR + E +MKK+ E + I L + + S
Sbjct: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES----SKAS 808
Query: 422 SVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAG 481
S+ + ++ +++S+ K +E EL +K ++ +S ++
Sbjct: 809 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868
Query: 482 KIA------SFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRK-- 533
K+ + S++L+ +L+ A E +++ K+K + + K
Sbjct: 869 KLHQKEEQFNMLSSDLEKLRENLA--DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 926
Query: 534 ----PLLESVPYEEALANR---RILLSSTESREGLAQQVQQSLEKIS-KLEQEKEHWMLE 585
L + E L R + L T++ E A +Q+S+E ++ K EQ ++ +
Sbjct: 927 GDNSSQLTKMNDELRLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQEAAKK 985
Query: 586 AQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSL 645
+ K +LE++ + K++ + + A+ A S T + E +L+ +Q T L
Sbjct: 986 HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE----ILQNLQKTLL 1041
Query: 646 IGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRLAL 705
D+E +RE+ + + + EL Q A K+ + + +++
Sbjct: 1042 --------DTEDKLKGAREE--NSGLLQELEELRKQADKA--KAAQTAEDAMQIMEQMTK 1089
Query: 706 AEKSKEALTEEMKLASQNISRLQDELTTTKRSY---EDQLSMMSDHLCSMNETLSKQREE 762
+ A E+ K Q ++LQ+EL T K + ++L+ + L N+ + + R+E
Sbjct: 1090 EKTETLASLEDTK---QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1146
Query: 763 IDTLKMSSKGNSKK 776
I+TLK ++ S++
Sbjct: 1147 IETLKQAAAQKSQQ 1160
Score = 45.4 bits (106), Expect = 2e-04
Identities = 137/708 (19%), Positives = 263/708 (37%), Gaps = 72/708 (10%)
Query: 91 KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELR-------SR 143
K SG ++ Q + ++K + +++ + E + + +A +E EL
Sbjct: 346 KISGTTALQEALKEKQ---QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQH 402
Query: 144 LATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQ 203
+ LE + Q + +V+ R+ +E + +L+ +K K+E +E+E+ + + + Q
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEES----ITKGDLETQ 458
Query: 204 LKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFV 263
K H + LE+SL K + V +R +L+ +D+A +
Sbjct: 459 TKLEHARIK-ELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELE-KDLALR----- 511
Query: 264 QDLVTALLNFHTYTEQRIQIFPVD---SAIDTISPLNQKFSQYLHENASYVRPLEEGMLH 320
V + E VD S + IS L +K ++ + L+E
Sbjct: 512 ---VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 568
Query: 321 LFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCT--SALR 378
E+ ++ + T KL +E L S + K + + + E+++ + A+
Sbjct: 569 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 628
Query: 379 ARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFH-DV 437
+ S+ + TA F +L+T I + L L+ S + +
Sbjct: 629 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 688
Query: 438 MKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIAS 497
MK I + + AI +L A + + + L+ + + A L+ A
Sbjct: 689 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL--------QEAEIKVKELEVLQAK 740
Query: 498 LSYGPKAASGFISPLSAE----CMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLS 553
+ K F S L A L +KA++ KS K L + + E +
Sbjct: 741 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 800
Query: 554 STESRE--GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQ 611
+ ES + + +++Q K++ L++ + E K LEKE Q + +K
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQEN----LSEVSQVKETLEKELQILKEKFAEA---- 852
Query: 612 LVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESR---EDLIK 668
AVS E K + Q L L + ++ + D+E++ +D +
Sbjct: 853 ------SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN-LADMEAKFREKDERE 905
Query: 669 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 728
+ +L + + S ++ ++ L L E+ E L ++ A++N S LQ
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Query: 729 DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKK 776
+S ED S E K EE L+ KK
Sbjct: 966 -------KSIEDMTVKAEQ---SQQEAAKKHEEEKKELERKLSDLEKK 1003
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.9 bits (154), Expect = 5e-10
Identities = 168/838 (20%), Positives = 328/838 (39%), Gaps = 121/838 (14%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
++L E L +N++L+K + + LK+ + + L+QE L N +L
Sbjct: 628 EELENELHHLEKENELLQKKITN-----------LKITCEKIEALEQENSELERENRKLK 676
Query: 71 KRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQ--------KKIE-ENER 121
K ++ ++ E K+N + E + +L + +S+ ++ K++E E E+
Sbjct: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 122 LHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEV 181
L K E L L+ E + Q ++ +K I++L+++ LE+
Sbjct: 737 LKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQKTLENSNKK----IQQLESELQDLEM 791
Query: 182 KSQTLEKEAKECRL---RTEECQLQLKTLHEDLS------GRLEESLSIINEKVPFNDTK 232
++QTL+K +E ++ R E+ + + K+L ++ S +LE+ + ++ DT
Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 233 YSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDT 292
+ NV + N + K + + ++ L ++ ++ +D I T
Sbjct: 852 LEEN---NVKIGNLEKENK---TLSKEIGIYKESCVRLKELEKENKELVKRATID--IKT 903
Query: 293 ISPLNQ-------KFSQYLHENASYVRPLE------EGMLHLFESITEDTVTVLETTVKL 339
+ L + K Q ++ LE E +LH +S + +LE+ ++
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE- 962
Query: 340 KTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKL- 398
T + L +I ++ +LE E S N +L Q++K + +E L
Sbjct: 963 STLKKSL--------EIKEEKIAALEARLEES------TNYNQQLRQELKTVKKNYEALK 1008
Query: 399 QTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTA 458
Q + S+ P + L D + ++ ++ + A + L T
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 459 TQKLITTNDCILSSVVAL-----------TNGAGKIASFFSNNLDYFIASLSYGPKAASG 507
++L T N+ + + ++AL T + A N S S + A
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
Query: 508 FISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRIL-LSSTESREGLAQQVQ 566
I S E + K +KSL L++ E L R+ S S+ G +
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1188
Query: 567 QSLE-KISKLEQE-----KEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENA 620
++LE + LE K+ LE +K+E+E + +K T +A+ L EN
Sbjct: 1189 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1248
Query: 621 AVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTS 680
+++T Q ++ T ++ +T + + + L + A +L
Sbjct: 1249 RLNHTYSQ----------LLKETEVL----QTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1294
Query: 681 QLQLADSKSVHFYAECRALSK-RLALAEKSKEALTEEMKLASQNISRLQDELTT------ 733
Q Q D S +C LS+ + L E+++ L + L QN + L+ + +
Sbjct: 1295 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1354
Query: 734 TKRSYEDQLSMMSDHLCSMNETLSKQREEID-----------TLKMSSKGNSKKNKSR 780
+R Y D+L+ + + E + Q + D TLKM SKK+ +R
Sbjct: 1355 EQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1412
Score = 50.1 bits (118), Expect = 8e-06
Identities = 158/772 (20%), Positives = 300/772 (38%), Gaps = 121/772 (15%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQA---NSAALKEQLKMKDQSLRKLQQ 57
+ + EL+ + ++L + L+A + ++ V Q + L++ L+ ++ +++L+
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 58 EMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDED----LQ 113
E+ L N L K +E L+ E K+NK + +SQL +++K + E+ Q
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 114 KKIEEN--ERLHIQFFEADEQHKHVEAELR------SRLATLETEAAQ--HQAVVDGLTR 163
+I++ E +++ ++++K + E+ RL LE E + +A +D +
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID--IK 902
Query: 164 KYMETIEKLQNDKAKLEVKSQTLEKEA---------KECRLRTEEC--QLQLKTLHEDLS 212
+ E L ++K K + + LEK KE L E+ + K L L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE 962
Query: 213 GRLEESLSIINEKVPF------NDTKYSQ------------YNALNVPLHNRRHQLKMRD 254
L++SL I EK+ T Y+Q Y AL R
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Query: 255 IAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPL 314
I+G+ + ++ ++ I+ V+ T+ Q L + + L
Sbjct: 1023 ISGEDNKWERESQETTRELLKVKDRLIE---VERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 315 EEGMLHLFE---SITEDTVTVLETTVKLKTFSEHLTSYICFL---RKILPYQLKSLEEEC 368
+ +L L S+ E T+ KL+ + L S L L Q SLE E
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 369 ESSLC-TSALRARNLELSQDMKKMTAVFEK-LQTYIALLALPSTEPDGL---------LR 417
ES + L++ L +D +K+ + E+ Y +L++ T L
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 418 TNYSSVLTNVG------AALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILS 471
Y+ +L G L + M +K++ AA +L +L T +L
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 472 SVVALTNGAGKIASFFSNN------LDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA 525
L + S +N+ L+ + L + + L+ +C L + K
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK-- 1317
Query: 526 AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKE----- 580
++ + LL+ + L NR +L + ES++ + +Q ++K+++L ++KE
Sbjct: 1318 GNLEEENRHLLDQI-QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Query: 581 -----------------HWMLEAQLAKIKLEKENQRIADK---LKNTGSAQLVGL----- 615
+W+ IK +K+ R K L T S G
Sbjct: 1377 IMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPH 1436
Query: 616 --AQENAAVSNTAGQDEAT-----AKAVLEPIQSTSLIGTLT-RTSDSEVPD 659
+Q++++V + + +D T + + + +QS L G T T + EVPD
Sbjct: 1437 QDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPD 1488
Score = 49.7 bits (117), Expect = 1e-05
Identities = 146/754 (19%), Positives = 296/754 (39%), Gaps = 85/754 (11%)
Query: 41 LKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQL 100
L +L +R+L+QE++ T + L + +E ++ EL + S+
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 101 SQE-----QKSVFDEDLQKKIEE-NERLH-IQFFEADEQHKHVEAELRSRLATLETEAAQ 153
E +K+V + L+ ++ ERLH I+F++A VE LET+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKA-----RVEELKEDNQVLLETKTML 363
Query: 154 HQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSG 213
+ TR + + +L+ + +L+ K +E E R + EE + TL
Sbjct: 364 EDQLEG--TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 214 RLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNF 273
++ESL + E + T P + H+ + ++ L ++ +L
Sbjct: 422 SMDESLHLGWELEQISRTS----ELSEAPQKSLGHE--VNELTSSRLLKLEMENQSLTK- 474
Query: 274 HTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVL 333
T E R + V+ I + +K +Q L + V LE ++ +S+ ++ +
Sbjct: 475 -TVEELRTTVDSVEGNASKILKM-EKENQRLSKK---VEILENEIVQEKQSL-QNCQNLS 528
Query: 334 ETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECES-SLCTSALRARNLELSQDMKKMT 392
+ +K K L I LR+ Q+K LE+E E + S+LR R+ ++S + +
Sbjct: 529 KDLMKEKA---QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS-QISAEARVKD 584
Query: 393 AVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIE 452
E + +L + + + + K++ +HY +K
Sbjct: 585 IEKE----------------NKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 453 HELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNN-------------LDYFIASLS 499
EL L N+ + + L KI + N LD F +L+
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF-KNLT 686
Query: 500 YGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESRE 559
+ ++ S L E + + + S++ L+ L N+ + + ++
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ-------LENKELESEKEQLKK 739
Query: 560 GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQEN 619
GL + ++ S +K +LE + +E Q + LE N++I ++L L EN
Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL-----ESELQDLEMEN 793
Query: 620 AAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELT 679
+ + + ++K + + + + T + + +E ++ A I + T
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ--QAEIKDTT 851
Query: 680 SQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYE 739
L+ + K + E + LSK + + ++S L E K + + R ++ T E
Sbjct: 852 --LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909
Query: 740 DQLSMMSDHLCS--MNETLSKQREEIDTLKMSSK 771
D ++S+ L + MN L K E++ + ++ +
Sbjct: 910 D---LVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/228 (21%), Positives = 112/228 (49%), Gaps = 28/228 (12%)
Query: 32 VDEQANSAALKEQLKMKDQSLRKLQQEMDS--------------LTFRNLQLAKRVELLQ 77
V+E +S LK L+M++QSL K +E+ + + N +L+K+VE+L+
Sbjct: 454 VNELTSSRLLK--LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 78 DELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVE 137
+E+ + K++ ++ ++ S+ ++K+ ++ ++ E +ER I+ E + +H +
Sbjct: 512 NEIV----QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQT 566
Query: 138 AELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEA---KECR 194
+ + + EA ++ + E+I++ + +K+E + + ++KE KE
Sbjct: 567 VSSLRQRSQISAEARVKD--IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624
Query: 195 LRTEECQLQLKTLHE--DLSGRLEESLSIINEKVPFNDTKYSQYNALN 240
R EE + +L L + +L + +L I EK+ + + S+ N
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN 672
Score = 39.3 bits (90), Expect = 0.014
Identities = 57/242 (23%), Positives = 99/242 (40%), Gaps = 44/242 (18%)
Query: 555 TESREGLAQQVQQSLEK-ISKLEQEKEHWMLEAQLAKI-KLEKENQRIADKLKNTGSAQL 612
T SR + QSL K + +L + +E +KI K+EKENQR++ K++ +
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDS--VEGNASKILKMEKENQRLSKKVEILENE-- 513
Query: 613 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 672
+ QE ++ N + K E Q I TL S+ ++ +E + H
Sbjct: 514 --IVQEKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENSERQIKILEQENE----HLN 564
Query: 673 ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 732
+ L + Q++ AE R EK + L E +K S +S+++ E
Sbjct: 565 QTVSSLRQRSQIS--------AEARVKD-----IEKENKILHESIKETSSKLSKIEFEKR 611
Query: 733 TTKRSYE---------DQLSMMSDHLCSMNETLSKQ-------REEIDTLKMSSKGNSKK 776
K+ E ++L HL NE L K+ E+I+ L+ + ++
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 777 NK 778
N+
Sbjct: 672 NR 673
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 62.8 bits (151), Expect = 1e-09
Identities = 148/752 (19%), Positives = 289/752 (38%), Gaps = 124/752 (16%)
Query: 41 LKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQL 100
+KE L+ + ++L+++M SL L +V+ QD L +E E QL
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE----------ERCDQL 910
Query: 101 SQEQKSVFDEDLQKKIEE-NERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVD 159
+ + L+ K++E NERL E + + AEL ++ LE E ++ + +D
Sbjct: 911 IKNK-----IQLEAKVKEMNERL--------EDEEEMNAELTAKKRKLEDECSELKKDID 957
Query: 160 GLTRKYMETIEKLQNDKAKLEVKSQTLEKE-----------AKECRLRTEECQLQLKTL- 207
L T+ K++ +K E K + L +E KE + E Q L L
Sbjct: 958 DLEL----TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1013
Query: 208 -HEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDL 266
ED L +S + ++V + Q + + L + +L+ L Q+
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE------GDLKLTQES 1067
Query: 267 VTALLNFHTYTEQRIQ-----IFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHL 321
+ L N E++++ I +S I+ L + + L EN + + LEE +
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL--- 1124
Query: 322 FESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARN 381
E T + K LR L +L+ + E E + ++++
Sbjct: 1125 ----------EAERTARAKVEK---------LRSDLSRELEEISERLEEAGGATSVQ--- 1162
Query: 382 LELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDI 441
+E++ KK A F+K++ + L LR ++ + +G + V + +
Sbjct: 1163 IEMN---KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 442 SKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYG 501
K +K+ + EL T + ++ K++ + + + L
Sbjct: 1220 EK---EKSEFKLELDDVTSN--------MEQIIKAKANLEKVSRTLEDQANEYRVKLEEA 1268
Query: 502 PKAASGF------ISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSST 555
++ + F + + E Q ++K A + R L + E+ +R L
Sbjct: 1269 QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL---KRQLEEEG 1325
Query: 556 ESREGLAQQVQQSLEKISKL-EQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVG 614
+++ LA +Q + L EQ +E +A+L ++ L K N +A
Sbjct: 1326 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV-LSKANSEVAQWRTK-------- 1376
Query: 615 LAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMAR 674
E A+ T +EA K + + +Q +++ +E + ++N
Sbjct: 1377 --YETDAIQRTEELEEA-KKKLAQRLQDAE---EAVEAVNAKCSSLEKTKHRLQN----E 1426
Query: 675 IVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTT 734
I +L ++ +++ + + R K LA ++ E E++ + + L EL
Sbjct: 1427 IEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486
Query: 735 KRSYEDQLSMMSDHLCSMNETLSKQREEIDTL 766
K +YE+ L +HL + +EEI L
Sbjct: 1487 KNAYEESL----EHLETFKRENKNLQEEISDL 1514
Score = 62.8 bits (151), Expect = 1e-09
Identities = 160/879 (18%), Positives = 345/879 (39%), Gaps = 137/879 (15%)
Query: 3 SAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL 62
+AEL K +KL E S+L KK + D + A ++++ + ++ L +EM L
Sbjct: 935 NAELTAKKRKLEDECSEL-------KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 987
Query: 63 TFRNLQLAKRVELLQD--ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENE 120
+L K + LQ+ + AL + + +++K + S S++ EQ+ +DL+ +E+ +
Sbjct: 988 DEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQV---DDLEGSLEQEK 1044
Query: 121 RLHIQFFEADEQ--------------HKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM 166
++ + A + ++ + +L +L E + Q + ++ +
Sbjct: 1045 KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLAL 1104
Query: 167 ETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKV 226
+ +KL+ ++A++E + LE E + R + E+ + L E++S RLEE+ + ++
Sbjct: 1105 QLQKKLKENQARIEELEEELEAE-RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1163
Query: 227 PFNDTKYSQYNALNVPLH-------------NRRHQLKMRDIAGQ--------------- 258
N + +++ + L ++H + ++ Q
Sbjct: 1164 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1223
Query: 259 ---------ALAFVQDLVTALLNFHTYT--------EQRIQIFPVDSAID-------TIS 294
+ ++ ++ A N + E R+++ +++ +
Sbjct: 1224 SEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQ 1283
Query: 295 PLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHL---TSYIC 351
N + ++ L E + + L G L + + ED LE K K H + C
Sbjct: 1284 TENGELARQLEEKEALISQLTRGKLSYTQQM-EDLKRQLEEEGKAKNALAHALQSARHDC 1342
Query: 352 FLRKILPYQLKSLEEECESSL-CTSALRARNLELSQ-------DMKKMTAVFEKLQTYIA 403
L + + EEE E+ L N E++Q D + T E+ + +A
Sbjct: 1343 DLLR------EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396
Query: 404 LLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHE-------LP 456
+ E + SS+ + D+M D+ + + AA++ + L
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1456
Query: 457 TATQKLITTNDCILSS---VVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLS 513
QK + + SS +L+ K+ + + +L++ + + K IS L+
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH-LETFKRENKNLQEEISDLT 1515
Query: 514 AECMLQYKKKAAAYMKSLRKPL-LESVPYEEALANR---------RILLSSTESREGLAQ 563
+ L K ++ +RK L +E + + AL +IL + E + A+
Sbjct: 1516 EQ--LGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1573
Query: 564 QVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKE----NQRIADKLKNTGSAQLVGLAQEN 619
++ EK ++EQ K + + L+ E N+ + K K G + + +
Sbjct: 1574 IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSH 1633
Query: 620 AAVSNTAGQDEATAKAVLEPIQSTSL-IGTLTRTSD---SEVPDVESREDLIKNHYMARI 675
A + A + + K++ ++ T + + R +D + VE R +L++ A +
Sbjct: 1634 A--NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ----AEL 1687
Query: 676 VELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTK 735
EL + ++ + E S+R+ L +L + K ++++LQ E+
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747
Query: 736 ---RSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSK 771
R+ E++ M E L K+++ L+ K
Sbjct: 1748 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1786
Score = 58.5 bits (140), Expect = 2e-08
Identities = 158/814 (19%), Positives = 319/814 (39%), Gaps = 97/814 (11%)
Query: 11 QKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLA 70
+K E+ K+R L++ + +A +AAL+ K S+ +L +++D+L +L
Sbjct: 1167 KKREAEFQKMRRD---LEEATLQHEATAAALR---KKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 71 KR---VELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFF 127
K +L D++ + + K K + E S+ ++Q + + + K+EE +R F
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY----RVKLEEAQRSLNDFT 1276
Query: 128 EADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLE 187
A+L++ L + + +A++ LTR + +++++ K +LE + +
Sbjct: 1277 TQ-------RAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 188 KEAKECRLRTEECQLQLKTLHEDLSGR--LEESLSIINEKVPFNDTKYSQYNAL--NVPL 243
A + +C L + E+ + L+ LS N +V TKY + +A+ L
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY-ETDAIQRTEEL 1388
Query: 244 HNRRHQLKMR-DIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVD-----SAIDTISPLN 297
+ +L R A +A+ V ++L + I+ VD +A +
Sbjct: 1389 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Query: 298 QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK-TFSEHLTSYICFLRKI 356
+ F + L A + + EE L ES ++ ++ KLK + E L F R
Sbjct: 1449 RNFDKIL---AEWKQKYEESQSEL-ESSQKEARSLSTELFKLKNAYEESLEHLETFKR-- 1502
Query: 357 LPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLL 416
+ K+L+EE +N+ + ++K V EKL+ AL E + L
Sbjct: 1503 ---ENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV-EKLELQSAL-----EEAEASL 1553
Query: 417 RTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVAL 476
+L A F+ + +I + ++K + Q+++ + L +
Sbjct: 1554 EHEEGKIL----RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 477 TNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPLL 536
N ++ +L+ LS+ + ++AE Q K + +K + L
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANR--------MAAEAQKQV-KSLQSLLKDTQIQLD 1660
Query: 537 ESVPYEEALANRRILLSSTESREGLAQ----QVQQSLEKISKLEQEKEHWMLEAQLAKIK 592
++V + L ++ E R L Q +++ +E+ + + E ++E
Sbjct: 1661 DAVRANDDLKEN---IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1717
Query: 593 LEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAV---------LEPIQST 643
L +N + ++ K S ++ AV +E KA+ L+ Q T
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDT 1777
Query: 644 SL-IGTLTRTSDSEVPDVESREDLIKNHYM-----------ARIVELTSQLQLADSKSVH 691
S + + + + + D++ R D + + AR+ EL +L+ ++
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 692 FYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCS 751
R +R+ K TEE K + L D+L ++Y+ Q + +
Sbjct: 1838 SVKGMRKSERRI----KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1893
Query: 752 MNETLSKQREEIDTLK-----MSSKGNSKKNKSR 780
K + E+D + S+ N + KSR
Sbjct: 1894 NLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 62.4 bits (150), Expect = 2e-09
Identities = 157/789 (19%), Positives = 313/789 (39%), Gaps = 120/789 (15%)
Query: 19 KLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQD 78
KL ++ ++ ++D + + ++E+LK K+ L +LQ ++D +LQ K+++ LQ
Sbjct: 1058 KLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQA 1117
Query: 79 ELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEA 138
+ E + ++ + ++Q+S +L++ E E E +K EA
Sbjct: 1118 RIEELE----EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 139 ELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTE 198
E + LE QH+A L +K +++ +L L+ Q LEKE E ++ +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
Query: 199 ECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQ 258
+ ++ L + S +E + + + ++S+ A + H L M+
Sbjct: 1234 DMASNIEALSKSKS-NIERTCRTVED-------QFSEIKAKDEQQTQLIHDLNMQ----- 1280
Query: 259 ALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGM 318
+ R+Q N + S + E S + L +
Sbjct: 1281 -------------------KARLQ------------TQNGELSHRVEEKESLISQLTKSK 1309
Query: 319 LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALR 378
L + + E+ +E K K H +L Q + E+E ++ L AL
Sbjct: 1310 QALTQQL-EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEE-EQEAKAEL-QRALS 1366
Query: 379 ARNLELSQ-------DMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAAL 431
N E++Q D + T E+ + +A L E + + + L L
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLA-QRLQEAEENTETANSKCASLEKTKQRL 1425
Query: 432 HG-FHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNN 490
G D+M+D+ + ++ A ++ + K+ + +
Sbjct: 1426 QGEVEDLMRDLERSHTACATLDKK----------------------QRNFDKVLAEWKQK 1463
Query: 491 LDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLR---KPLLESV-PYEEALA 546
LD A L K + + L M ++ +++LR K L E + E +A
Sbjct: 1464 LDESQAELEAAQKESRSLSTELFK--MRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 547 NRRILLSSTESREGLAQQVQQSLE-KISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLK 605
L E + L +Q + L+ + ++E EH E+++ +++LE ++K
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH--EESKILRVQLE------LSQVK 1573
Query: 606 NTGSAQLVGLAQENAAVSNTAGQDEATAKAVLE-PIQSTSLIGTLTRTSDSEVPDVESRE 664
+ +++ +E + + + ++VL+ I+S + L + + ++ ++E +
Sbjct: 1574 SELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633
Query: 665 DLIKNHYMARIVE--LTSQLQLADSKSVHFYAECRA---LSKRLALAEKSKEAL---TEE 716
N MA + T Q QL DS+ +H R+ L ++LA+ E+ L EE
Sbjct: 1634 G-HSNRQMAETQKHLRTVQGQLKDSQ-LHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691
Query: 717 MKLASQNISRLQDELTTTKRSYEDQLSMMSDH---LCSMNETL--SKQREEIDTLKMSSK 771
MK+A + R T+R E +L SD L S N +L +K++ E D + ++
Sbjct: 1692 MKVALEQTER-------TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAE 1744
Query: 772 GNSKKNKSR 780
+ +SR
Sbjct: 1745 VENSIQESR 1753
Score = 60.1 bits (144), Expect = 8e-09
Identities = 156/811 (19%), Positives = 327/811 (40%), Gaps = 94/811 (11%)
Query: 7 QGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAA-LKEQLKMKDQSLRKLQQEMDSLTFR 65
+ ++QK+ ++ + Q++ + +QA+S A L EQ+ + +KL++E L
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 66 NLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQ 125
+A +E L K+K + E + + ++Q F E K ++ + +H
Sbjct: 1232 IDDMASNIEALS-----------KSKSNIERTCRTVEDQ---FSEIKAKDEQQTQLIHDL 1277
Query: 126 FFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQT 185
+ +A L+++ L + ++++ LT+ ++L+ K ++E +++
Sbjct: 1278 NMQ--------KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA 1329
Query: 186 LEKEAKECRLRTEECQLQLKTLHEDLSGR--LEESLSIINEKVPFNDTKYSQYNAL--NV 241
A + +C L + E+ + L+ +LS N +V TKY + +A+
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY-ETDAIQRTE 1388
Query: 242 PLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQ------IFPVDSAIDTISP 295
L + +L R + + A L T+QR+Q + ++ + +
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLE---KTKQRLQGEVEDLMRDLERSHTACAT 1445
Query: 296 LNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRK 355
L++K + A + + L+E L E+ +++ ++ K++ E + + LR+
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAEL-EAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504
Query: 356 ILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGL 415
+ K+L+EE A +NL+ ++ KK+ EK +AL E +G
Sbjct: 1505 ----ENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ-EKSDLQVAL-----EEVEGS 1554
Query: 416 LRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVA 475
L S +L V L V ++ + +K +L +Q+ +L + +
Sbjct: 1555 LEHEESKIL-RVQLEL---SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 476 LTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAAAYMKSLRKPL 535
N A ++ +L+ L + + AE ++ + +K + L
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQ--------MAETQ-KHLRTVQGQLKDSQLHL 1661
Query: 536 LESVPYEEALANRRILLSSTESREGL----AQQVQQSLEKISKLEQEKEHWMLEAQLAKI 591
+++ E L + L+ E R GL ++++ +LE+ + + E +L+A
Sbjct: 1662 DDALRSNEDLKEQ---LAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQ 1718
Query: 592 KLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAV---------LEPIQS 642
L +N + + K + A+ ++ + +E KA+ L+ Q
Sbjct: 1719 LLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 643 TSL-IGTLTRTSDSEVPDVESR----EDLIKNHYMARIVELTSQL-QLADSKSVHFYAEC 696
TS + + + + V D++ R E L +I +L +++ +L + V
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGA 1838
Query: 697 RALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTTKRSYEDQLSMMSDHLCSMN 753
AL K KE +T + + +NI RLQ D+L +SY+ Q + N
Sbjct: 1839 EALKGAHKYERKVKE-MTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE---QAN 1894
Query: 754 ETLSK----QREEIDTLKMSSKGNSKKNKSR 780
LS+ Q E + + + S+ NK R
Sbjct: 1895 TQLSRCRRVQHELEEAAERADIAESQVNKLR 1925
Score = 43.5 bits (101), Expect = 8e-04
Identities = 78/394 (19%), Positives = 155/394 (39%), Gaps = 42/394 (10%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFR 65
LQG+ + L ++ + L K + A K++L L Q+E SL+
Sbjct: 1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 66 NLQLAKRVELLQDELALSEPRGKK-NKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
++ E + D+L K ++ + + Q+++ K++ + + KK+ E E+ +
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL 1544
Query: 125 QF----FEADEQHK-----HVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQ-- 173
Q E +H+ V+ EL + L+ + + ++ L R E LQ
Sbjct: 1545 QVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSV 1604
Query: 174 --------ND----KAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSI 221
ND K K+E +E + + E Q L+T + G+L++S
Sbjct: 1605 LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT----VQGQLKDSQLH 1660
Query: 222 INEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTE--Q 279
+++ + N+ Q + + RR+ L + ++ +A Q T L+ +
Sbjct: 1661 LDDALRSNEDLKEQ-----LAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 280 RIQIFPVD--SAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTV 337
R+Q+ S I+T L +Q E + ++ ++IT D + E
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAIT-DAAMMAEELK 1774
Query: 338 KLKTFSEHLTSYICFLRKILPYQLKSLEEECESS 371
K + S HL ++K L +K L+ + +
Sbjct: 1775 KEQDTSAHLER----MKKNLEQTVKDLQHRLDEA 1804
Score = 35.0 bits (79), Expect = 0.27
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 27/144 (18%)
Query: 659 DVESR-EDLIKNHYM--ARIVELTSQLQLADSKSVHFYAECRALSKR------------- 702
D E R E LIK+ + A++ ELT +L+ + + A+ R L +
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 703 -LALAEKSKEA-------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCS 751
L EK K A L+EEM +NIS+L E + + +++ D L + D +
Sbjct: 964 TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNG 1023
Query: 752 MNETLSKQREEIDTLKMSSKGNSK 775
+ + +K ++ D L+ S + K
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKK 1047
Score = 32.0 bits (71), Expect = 2.3
Identities = 45/215 (20%), Positives = 91/215 (42%), Gaps = 10/215 (4%)
Query: 554 STESR-EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQL 612
+TE++ + L++++ E ISKL +EK+ Q L+ E ++ +K
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK--- 1030
Query: 613 VGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYM 672
L Q+ + + Q E +A LE + L G L + +S + D+E+ + I+
Sbjct: 1031 --LEQQTDDLEGSLEQ-EKKLRADLERAKR-KLEGDLKMSQES-IMDLENDKQQIEEKLK 1085
Query: 673 ARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELT 732
+ EL+ D + VH + + + A E+ +E + E L ++ I + + +L
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK-IEKQRSDLA 1144
Query: 733 TTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK 767
++L S + E K+ E ++
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179
Score = 31.6 bits (70), Expect = 3.0
Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 4/86 (4%)
Query: 677 ELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKR 736
+L Q+Q + C L K L E + LTE ++ + + EL KR
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEE----MNSELVAKKR 945
Query: 737 SYEDQLSMMSDHLCSMNETLSKQREE 762
+ ED+ S + + + TL+K +E
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKE 971
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 62.4 bits (150), Expect = 2e-09
Identities = 179/889 (20%), Positives = 343/889 (38%), Gaps = 163/889 (18%)
Query: 21 RAQNQVLKKG---VVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF--RNLQLAKRVEL 75
R ++ +LK+G + D Q S + ++ + LR L+ + S T N L K +E
Sbjct: 377 RKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSM-LRPLELSLPSQTSYSENEILKKELEA 435
Query: 76 L--------QDELALSEPRGKK-----------NKKSGESSSQLSQEQKSVFDEDLQKKI 116
+ QD L L K + +S Q+ Q + ++ +D+QK++
Sbjct: 436 MRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL--KDVQKRM 493
Query: 117 EENE-------------RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTR 163
E+E + H+ A H+ E EL+ +L L+ + A V L
Sbjct: 494 YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKYEGASAEVGKLRN 552
Query: 164 KYMET---IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH---EDLSGRLEE 217
+ + +E+ + D+ KL +++ L+KE C + E+ ++ + ++LS +L
Sbjct: 553 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL-- 610
Query: 218 SLSIINEKVPFNDTKYSQYNALNVPLHN-----RRHQLKMRDIAGQALAFVQDLVTALLN 272
+LSI EK F + K S N +N R H+ + +I + L + V A L
Sbjct: 611 ALSIPAEK--FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI--RQLKRELENVKAKLA 666
Query: 273 FHTYTEQRIQIFPVDSAIDTIS-PLNQKFSQYLHENASYVRPLEEGMLH---LFESITED 328
H E+ Q V S ++ S L +K ++ +N + + +E+ L L E
Sbjct: 667 QHVKPEEHEQ---VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 723
Query: 329 TVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDM 388
T+ + V LK + S+ + + L ++ E L L N LS+D+
Sbjct: 724 TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV 783
Query: 389 KKMTAVF---EKLQTYIALLALPSTEPDGLL--------------------RTNYSSVLT 425
++ VF EK + I L E L TN +++
Sbjct: 784 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 843
Query: 426 NVGAALHGFHDV--------------MKDISKHYS----QKAAIEHELPTATQKLITTND 467
N + +V + D+ K + + I+ + + L T +
Sbjct: 844 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQN 903
Query: 468 CILSSVVALTNGAGKIASFFSN--NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA 525
I + ++L K++S + + A + + I L AE Q KK+
Sbjct: 904 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-KKELD 962
Query: 526 AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ---SLEKISKLEQE---- 578
+ ++ V +EE R+ + E ++ L++Q Q+ S E++ K +QE
Sbjct: 963 TIQECIKVKYAPIVSFEEC--ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1020
Query: 579 -KEHWMLEAQLAK----IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQ-DEAT 632
KE + L+ L I+ E +R + + + QL L+Q+ V N + E
Sbjct: 1021 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1080
Query: 633 AKAVLEPIQSTSL----------IGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQL 682
AK E + +L + L ++ + + +++ ++ Y +T
Sbjct: 1081 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1140
Query: 683 QLADSK-------SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTK 735
QL +++ + H + A K + + + S EE + + +S+LQ E+ TK
Sbjct: 1141 QLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTK 1199
Query: 736 RS---------------------YEDQLSMMSDHLCSMNETLSKQREEI 763
++ E Q+S +++ L ++N + EE+
Sbjct: 1200 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV 1248
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/415 (19%), Positives = 169/415 (40%), Gaps = 53/415 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
+++ K++ + QE+ K++ +N++LK+ + + Q A L + + L Q M +
Sbjct: 872 DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQD 931
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
N ++ Q+E+ K KK ++ +Q+ I+ +
Sbjct: 932 SNAEILANYRKGQEEIVTLHAEIKAQKKELDT---------------IQECIKVKYAPIV 976
Query: 125 QFFEADEQHKHVEAELRSRL-------ATLETEAAQHQAVVDGLTRKYMETIEKLQNDKA 177
F E + + K E EL+ +L + E E +++ D L +K + T++K DK
Sbjct: 977 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL-KKEIFTLQKDLRDKT 1035
Query: 178 KLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYN 237
L KS +E+ +T+E QLK DLS + E ++ + V N + S+
Sbjct: 1036 VLIEKSHEMERALSR---KTDELNKQLK----DLSQKYTEVKNVKEKLVEENAKQTSEIL 1088
Query: 238 ALNVPLHNRRHQLKMRDIAGQAL-AFVQDLVTALLNF-HTYTEQRIQIFPVDSAIDTISP 295
A+ L + L+ + ++L +++L L + Y +++ + + ++
Sbjct: 1089 AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKN 1148
Query: 296 LNQKFSQYLHENASY----------VRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ +++L ++ +R EE + E +++ V T LK
Sbjct: 1149 SSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETR 1208
Query: 346 ----LTSYICFLRKILPYQLKSLEEECES------SLCTSALRARNLELSQDMKK 390
L+ Y + L Q+ SL E+ + +C L A+ E+S +K
Sbjct: 1209 EVVDLSKYKA-TKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1262
Score = 47.0 bits (110), Expect = 7e-05
Identities = 152/780 (19%), Positives = 297/780 (38%), Gaps = 113/780 (14%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
+ L+ K +L ++ ++L +NQ L+K + ++ LKEQ
Sbjct: 679 SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQA------------------ 720
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGES-SSQLSQEQKSVFDEDLQKKIEENERL 122
NL + + + L +SE KKS ++ L+++ V + +KK+E + L
Sbjct: 721 -HNLTIEMKNHYV--PLKVSEDM----KKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 773
Query: 123 HIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL--- 179
E D K V SRL T+ +H+ + L +E ++L K K
Sbjct: 774 ----LENDSLSKDV-----SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 824
Query: 180 EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 239
+ K L E + + +KT HE++ L ++L+ N ++ K+ N
Sbjct: 825 QEKIHALTSENTNLKKMMSNQYVPVKT-HEEVKMTLNDTLAKTNRELLDVKKKFEDINQE 883
Query: 240 NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQK 299
V + ++ LK + L Q+ + A + + E ++ + ++ + N +
Sbjct: 884 FVKIKDKNEILK------RNLENTQNQIKA--EYISLAEHEAKMSSLSQSMRKVQDSNAE 935
Query: 300 FSQYLHENASYVRPLEEGM-LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILP 358
A+Y + EE + LH + + ++ +K+K ++ ++ C
Sbjct: 936 IL------ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK-YAPIVSFEEC------E 982
Query: 359 YQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRT 418
+ K+ E+E + L + E +++KK +KL+ I L + L+
Sbjct: 983 RKFKATEKELKDQLSEQTQKYSVSE--EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1040
Query: 419 NYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTN 478
++ + + + +KD+S+ Y+ E+ +KL+ N S ++A+ N
Sbjct: 1041 SH-EMERALSRKTDELNKQLKDLSQKYT-------EVKNVKEKLVEENAKQTSEILAVQN 1092
Query: 479 GAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ---YKKKAAAY-------- 527
+ + K+ +G I L E Y+K+
Sbjct: 1093 --------LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1144
Query: 528 -MKSLRKPLLESVPYEEALANR-RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLE 585
K+ PL E + +EA I+ +S +E ++ Q +E++SKL+ E ++
Sbjct: 1145 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKE---EESQNKMEEVSKLQSEVQN---- 1197
Query: 586 AQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVL----EPIQ 641
+ A KLE K K T S ++ N ++N + E + VL + I
Sbjct: 1198 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEIS 1257
Query: 642 STSLIGTLTRTSDSEVPDVESRED---LIKNHYMARIVELTSQLQLADSKSVHFYAECRA 698
+ L + + E+ D + R D RI E Q++ D+K +
Sbjct: 1258 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1317
Query: 699 LSKRLALAEKSKEALTEEMKLASQNISRLQ-------DELTTTKRSYEDQLSMMSDHLCS 751
L + L + K SQ I LQ +L R +++ +++ HL S
Sbjct: 1318 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1377
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 62.4 bits (150), Expect = 2e-09
Identities = 179/889 (20%), Positives = 343/889 (38%), Gaps = 163/889 (18%)
Query: 21 RAQNQVLKKG---VVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF--RNLQLAKRVEL 75
R ++ +LK+G + D Q S + ++ + LR L+ + S T N L K +E
Sbjct: 390 RKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSM-LRPLELSLPSQTSYSENEILKKELEA 448
Query: 76 L--------QDELALSEPRGKK-----------NKKSGESSSQLSQEQKSVFDEDLQKKI 116
+ QD L L K + +S Q+ Q + ++ +D+QK++
Sbjct: 449 MRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL--KDVQKRM 506
Query: 117 EENE-------------RLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTR 163
E+E + H+ A H+ E EL+ +L L+ + A V L
Sbjct: 507 YESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE-ELKDQLKDLKVKYEGASAEVGKLRN 565
Query: 164 KYMET---IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH---EDLSGRLEE 217
+ + +E+ + D+ KL +++ L+KE C + E+ ++ + ++LS +L
Sbjct: 566 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL-- 623
Query: 218 SLSIINEKVPFNDTKYSQYNALNVPLHN-----RRHQLKMRDIAGQALAFVQDLVTALLN 272
+LSI EK F + K S N +N R H+ + +I + L + V A L
Sbjct: 624 ALSIPAEK--FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI--RQLKRELENVKAKLA 679
Query: 273 FHTYTEQRIQIFPVDSAIDTIS-PLNQKFSQYLHENASYVRPLEEGMLH---LFESITED 328
H E+ Q V S ++ S L +K ++ +N + + +E+ L L E
Sbjct: 680 QHVKPEEHEQ---VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 736
Query: 329 TVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDM 388
T+ + V LK + S+ + + L ++ E L L N LS+D+
Sbjct: 737 TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV 796
Query: 389 KKMTAVF---EKLQTYIALLALPSTEPDGLL--------------------RTNYSSVLT 425
++ VF EK + I L E L TN +++
Sbjct: 797 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 856
Query: 426 NVGAALHGFHDV--------------MKDISKHYS----QKAAIEHELPTATQKLITTND 467
N + +V + D+ K + + I+ + + L T +
Sbjct: 857 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQN 916
Query: 468 CILSSVVALTNGAGKIASFFSN--NLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA 525
I + ++L K++S + + A + + I L AE Q KK+
Sbjct: 917 QIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-KKELD 975
Query: 526 AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQ---SLEKISKLEQE---- 578
+ ++ V +EE R+ + E ++ L++Q Q+ S E++ K +QE
Sbjct: 976 TIQECIKVKYAPIVSFEEC--ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL 1033
Query: 579 -KEHWMLEAQLAK----IKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQ-DEAT 632
KE + L+ L I+ E +R + + + QL L+Q+ V N + E
Sbjct: 1034 KKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEEN 1093
Query: 633 AKAVLEPIQSTSL----------IGTLTRTSDSEVPDVESREDLIKNHYMARIVELTSQL 682
AK E + +L + L ++ + + +++ ++ Y +T
Sbjct: 1094 AKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH 1153
Query: 683 QLADSK-------SVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTK 735
QL +++ + H + A K + + + S EE + + +S+LQ E+ TK
Sbjct: 1154 QLLENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTK 1212
Query: 736 RS---------------------YEDQLSMMSDHLCSMNETLSKQREEI 763
++ E Q+S +++ L ++N + EE+
Sbjct: 1213 QALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV 1261
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/415 (19%), Positives = 169/415 (40%), Gaps = 53/415 (12%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
+++ K++ + QE+ K++ +N++LK+ + + Q A L + + L Q M +
Sbjct: 885 DVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQD 944
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
N ++ Q+E+ K KK ++ +Q+ I+ +
Sbjct: 945 SNAEILANYRKGQEEIVTLHAEIKAQKKELDT---------------IQECIKVKYAPIV 989
Query: 125 QFFEADEQHKHVEAELRSRL-------ATLETEAAQHQAVVDGLTRKYMETIEKLQNDKA 177
F E + + K E EL+ +L + E E +++ D L +K + T++K DK
Sbjct: 990 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKL-KKEIFTLQKDLRDKT 1048
Query: 178 KLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYN 237
L KS +E+ +T+E QLK DLS + E ++ + V N + S+
Sbjct: 1049 VLIEKSHEMERALSR---KTDELNKQLK----DLSQKYTEVKNVKEKLVEENAKQTSEIL 1101
Query: 238 ALNVPLHNRRHQLKMRDIAGQAL-AFVQDLVTALLNF-HTYTEQRIQIFPVDSAIDTISP 295
A+ L + L+ + ++L +++L L + Y +++ + + ++
Sbjct: 1102 AVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKN 1161
Query: 296 LNQKFSQYLHENASY----------VRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEH 345
+ +++L ++ +R EE + E +++ V T LK
Sbjct: 1162 SSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETR 1221
Query: 346 ----LTSYICFLRKILPYQLKSLEEECES------SLCTSALRARNLELSQDMKK 390
L+ Y + L Q+ SL E+ + +C L A+ E+S +K
Sbjct: 1222 EVVDLSKYKA-TKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEK 1275
Score = 47.0 bits (110), Expect = 7e-05
Identities = 152/780 (19%), Positives = 297/780 (38%), Gaps = 113/780 (14%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLT 63
+ L+ K +L ++ ++L +NQ L+K + ++ LKEQ
Sbjct: 692 SRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQA------------------ 733
Query: 64 FRNLQLAKRVELLQDELALSEPRGKKNKKSGES-SSQLSQEQKSVFDEDLQKKIEENERL 122
NL + + + L +SE KKS ++ L+++ V + +KK+E + L
Sbjct: 734 -HNLTIEMKNHYV--PLKVSEDM----KKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 786
Query: 123 HIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL--- 179
E D K V SRL T+ +H+ + L +E ++L K K
Sbjct: 787 ----LENDSLSKDV-----SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGED 837
Query: 180 EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNAL 239
+ K L E + + +KT HE++ L ++L+ N ++ K+ N
Sbjct: 838 QEKIHALTSENTNLKKMMSNQYVPVKT-HEEVKMTLNDTLAKTNRELLDVKKKFEDINQE 896
Query: 240 NVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQK 299
V + ++ LK + L Q+ + A + + E ++ + ++ + N +
Sbjct: 897 FVKIKDKNEILK------RNLENTQNQIKA--EYISLAEHEAKMSSLSQSMRKVQDSNAE 948
Query: 300 FSQYLHENASYVRPLEEGM-LHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILP 358
A+Y + EE + LH + + ++ +K+K ++ ++ C
Sbjct: 949 IL------ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK-YAPIVSFEEC------E 995
Query: 359 YQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRT 418
+ K+ E+E + L + E +++KK +KL+ I L + L+
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSE--EEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1053
Query: 419 NYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTN 478
++ + + + +KD+S+ Y+ E+ +KL+ N S ++A+ N
Sbjct: 1054 SH-EMERALSRKTDELNKQLKDLSQKYT-------EVKNVKEKLVEENAKQTSEILAVQN 1105
Query: 479 GAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQ---YKKKAAAY-------- 527
+ + K+ +G I L E Y+K+
Sbjct: 1106 --------LLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE 1157
Query: 528 -MKSLRKPLLESVPYEEALANR-RILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLE 585
K+ PL E + +EA I+ +S +E ++ Q +E++SKL+ E ++
Sbjct: 1158 NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKE---EESQNKMEEVSKLQSEVQN---- 1210
Query: 586 AQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVL----EPIQ 641
+ A KLE K K T S ++ N ++N + E + VL + I
Sbjct: 1211 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEIS 1270
Query: 642 STSLIGTLTRTSDSEVPDVESRED---LIKNHYMARIVELTSQLQLADSKSVHFYAECRA 698
+ L + + E+ D + R D RI E Q++ D+K +
Sbjct: 1271 AKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVER 1330
Query: 699 LSKRLALAEKSKEALTEEMKLASQNISRLQ-------DELTTTKRSYEDQLSMMSDHLCS 751
L + L + K SQ I LQ +L R +++ +++ HL S
Sbjct: 1331 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1390
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 62.4 bits (150), Expect = 2e-09
Identities = 178/831 (21%), Positives = 326/831 (39%), Gaps = 134/831 (16%)
Query: 9 KYQKLAQEYSK----LRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRK----LQQEMD 60
K+QKL ++ + + LKK D A E L+ Q L K LQ E+D
Sbjct: 1182 KFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD 1241
Query: 61 SLTFRNLQLAKRVELLQDELALSEPR----GKKNKKSGESSSQLSQEQKSVFDE--DLQK 114
L R Q+ + + L E R K K + ++ L+ ++ ++ E + +
Sbjct: 1242 DLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLR 1301
Query: 115 KIEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYM------ET 168
++EE E L Q +LR +L E E A+ L + E
Sbjct: 1302 RLEEKEALINQLSREKSNFTRQIEDLRGQL---EKETKSQSALAHALQKAQRDCDLLREQ 1358
Query: 169 IEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQ----LKTLHEDLSGRLEESLSIINE 224
E+ Q KA+L + E + R++ E +Q L+ ++L+ RL+E+ +
Sbjct: 1359 YEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGV 1418
Query: 225 KVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIF 284
NA N L RHQL++ G AL+ + + +A
Sbjct: 1419 A-----------NARNASLERARHQLQLE--LGDALSDLGKVRSAAAR------------ 1453
Query: 285 PVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLK-TFS 343
L+QK Q A + + EE L ++ ++ + +KLK T+
Sbjct: 1454 -----------LDQKQLQSGKALADWKQKHEESQA-LLDASQKEVQALSTELLKLKNTYE 1501
Query: 344 EHLTSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIA 403
E + ++ L + K+L+EE + T+ +R L++ M+K+ + E+ +T +
Sbjct: 1502 ESIVG-----QETLRRENKNLQEEISN--LTNQVREGTKNLTE-MEKVKKLIEEEKTEVQ 1553
Query: 404 LLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLI 463
+ E +G L N S +L L ++ + +S+ + + L
Sbjct: 1554 VTL---EETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQ 1610
Query: 464 TTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKK 523
++ D S + +T ++ +L+ LS + S L LQ + K
Sbjct: 1611 SSLDSEAKSRIEVT----RLKKKMEEDLNEMELQLSCANRQVSEATKSLG---QLQIQIK 1663
Query: 524 AAAYMKSLRKPLLESVPYEEALANRR--ILLSSTESREGLAQQVQ-----------QSLE 570
L + + A+A RR +L S E L +Q + ++ E
Sbjct: 1664 DLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATE 1723
Query: 571 KI--------SKLEQEKEHWMLEAQLAKIKLEKEN-----QRIADKLKNTGSAQLVGLAQ 617
+I S L Q+K+ LEA +A+++ E E Q +K K + + L++
Sbjct: 1724 RINLFYTQNTSLLSQKKK---LEADVARMQKEAEEVVQECQNAEEKAKKA-AIEAANLSE 1779
Query: 618 ENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVE 677
E +T E T + + + I T L L + + SR+ + K +R+ E
Sbjct: 1780 ELKKKQDTIAHLERTRENMEQTI--TDLQKRLAEAEQMAL--MGSRKQIQKLE--SRVRE 1833
Query: 678 LTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ---DELTTT 734
L +L+ +S AE + ++RL E+ + LT + + +N+SR+Q D+L
Sbjct: 1834 LEGELEGEIRRS----AEAQRGARRL---ERCIKELTYQAEEDKKNLSRMQTQMDKLQLK 1886
Query: 735 KRSYEDQLSMMSDHLCSMNETLSKQREEIDTLK-----MSSKGNSKKNKSR 780
++Y+ Q+ + KQ+ E++ +K S+ N K K+R
Sbjct: 1887 VQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAR 1937
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/224 (21%), Positives = 100/224 (44%), Gaps = 25/224 (11%)
Query: 6 LQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDS-LTF 64
L+ + LA+E K + + V +E+ A L++ +K ++ L++++++ T
Sbjct: 1081 LESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTT 1140
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
R +R +L QD L+E + + G S +QL E +K+ + ++LH
Sbjct: 1141 RAKMERERADLTQDLADLNE---RLEEVGGSSLAQL---------EITKKQETKFQKLHR 1188
Query: 125 QFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQ 184
EA + A L+ R A A ++G + +KL+ DK+ L+++
Sbjct: 1189 DMEEATLHFETTSASLKKR-------HADSLAELEGQVENLQQVKQKLEKDKSDLQLEVD 1241
Query: 185 ---TLEKEAKECRLRTEE-CQLQLKTLHEDLSGRLEESLSIINE 224
T ++ + E+ C L + LHE + +L++ + N+
Sbjct: 1242 DLLTRVEQMTRAKANAEKLCTLYEERLHE-ATAKLDKVTQLAND 1284
Score = 41.2 bits (95), Expect = 0.004
Identities = 172/855 (20%), Positives = 315/855 (36%), Gaps = 163/855 (19%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
EL+ K L QE + L Q Q EQ A ++EQ + +S K+Q E
Sbjct: 884 ELKAKQVSLTQEKNDLILQLQA-------EQETLANVEEQCEWLIKS--KIQLEA----- 929
Query: 65 RNLQLAKRVELLQDELALSEPRGKK-NKKSGESSSQLSQEQKSVFDEDLQKKIEENERLH 123
R +L++RVE ++ + RG+K + E ++ + + + +K+ E++
Sbjct: 930 RVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHK--- 986
Query: 124 IQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKS 183
++ + + + + +R A + EA HQ +D L + E + L KLE +
Sbjct: 987 VKNLTEEVEFLNEDISKLNRAAKVVQEA--HQQTLDDLHME-EEKLSSLSKANLKLEQQV 1043
Query: 184 QTLEKEAKECRLRTEECQLQLKTLHEDLS------GRLEESLSIINEKVPFNDTKYSQYN 237
LE ++ R C+ +L L +L LE S + E++ + + SQ N
Sbjct: 1044 DELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMN 1103
Query: 238 ALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLN 297
+ K+ + G LV L T E + QI + ++
Sbjct: 1104 S------------KVENEKG--------LVAQLQK--TVKELQTQIKDLKEKLEAERTTR 1141
Query: 298 QKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSE-----------HL 346
K + E A + L + + E + ++ LE T K +T + H
Sbjct: 1142 AKMER---ERADLTQDLAD-LNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHF 1197
Query: 347 TSYICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAVFEKLQTYIALLA 406
+ L+K L LE + E+ L+ +L +D + + L T + +
Sbjct: 1198 ETTSASLKKRHADSLAELEGQVEN------LQQVKQKLEKDKSDLQLEVDDLLTRVEQMT 1251
Query: 407 LPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQKLITTN 466
+ L T Y L A L + D++ +QK + E ++
Sbjct: 1252 RAKANAEKLC-TLYEERLHEATAKLDKVTQLANDLA---AQKTKLWSESGEFLRR----- 1302
Query: 467 DCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPL---SAECML---QY 520
L AL N + S F+ ++ L K+ S L +C L QY
Sbjct: 1303 ---LEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQY 1359
Query: 521 KKK---AAAYMKSLRKPLLESVPYEEALANRRILLSS--TESREGLAQQVQQSLEKI--- 572
+++ A ++L K E V + N I + ++++ LA ++Q++ E +
Sbjct: 1360 EEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVA 1419
Query: 573 ----SKLEQEKEHWMLE-----AQLAKIK----------------------LEKENQRIA 601
+ LE+ + LE + L K++ +E+Q +
Sbjct: 1420 NARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALL 1479
Query: 602 D--------------KLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIG 647
D KLKNT +VG QE N Q+E + + + G
Sbjct: 1480 DASQKEVQALSTELLKLKNTYEESIVG--QETLRRENKNLQEE------ISNLTNQVREG 1531
Query: 648 TLTRTSDSEVPDVESREDLIKNHYMARIVELTSQLQLADSKSVHFYAECRALSKRL--AL 705
T T +V + E K + E L+ +SK +HF E L L
Sbjct: 1532 TKNLTEMEKVKKLIEEE---KTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKL 1588
Query: 706 AEKSKE---------ALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMNETL 756
+EK +E + ++ + + ++ + E+T K+ E+ L+ M L N +
Sbjct: 1589 SEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQV 1648
Query: 757 SKQREEIDTLKMSSK 771
S+ + + L++ K
Sbjct: 1649 SEATKSLGQLQIQIK 1663
Score = 34.7 bits (78), Expect = 0.35
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 31/188 (16%)
Query: 611 QLVGLAQENAAVSNTAGQ-----DEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESRED 665
++ GL +E A + + +E AK V + LI L ++ E E
Sbjct: 860 EVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEW 919
Query: 666 LIKNHYM--ARIVELTSQLQLADSKSVHFYA-------ECRALSKR-------LALAEKS 709
LIK+ AR+ EL+ +++ + + A EC L K L +EK
Sbjct: 920 LIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKE 979
Query: 710 KEA-------LTEEMKLASQNISRLQDELTTTKRSYE---DQLSMMSDHLCSMNETLSKQ 759
K LTEE++ +++IS+L + +++ D L M + L S+++ K
Sbjct: 980 KRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKL 1039
Query: 760 REEIDTLK 767
+++D L+
Sbjct: 1040 EQQVDELE 1047
Score = 32.3 bits (72), Expect = 1.7
Identities = 34/206 (16%), Positives = 97/206 (47%), Gaps = 24/206 (11%)
Query: 4 AELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSL- 62
A +Q + +++ QE + KK ++ +A L E+LK K ++ L++ +++
Sbjct: 1747 ARMQKEAEEVVQECQNAEEK---AKKAAIE----AANLSEELKKKQDTIAHLERTRENME 1799
Query: 63 -TFRNLQL----AKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIE 117
T +LQ A+++ L+ + + + + GE ++ + ++ Q+
Sbjct: 1800 QTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEA------QRGAR 1853
Query: 118 ENERLHIQF-FEADEQHKHVEAELRSRLATLETEA---AQHQAVVDGLTRKYMETIEKLQ 173
ER + ++A+E K++ + +++++ L+ + Q V + +Y+ +K Q
Sbjct: 1854 RLERCIKELTYQAEEDKKNL-SRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQ 1912
Query: 174 NDKAKLEVKSQTLEKEAKECRLRTEE 199
++ +++ +++ E + + +++ E
Sbjct: 1913 HELNEVKERAEVAESQVNKLKIKARE 1938
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 62.4 bits (150), Expect = 2e-09
Identities = 160/866 (18%), Positives = 325/866 (37%), Gaps = 147/866 (16%)
Query: 5 ELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTF 64
E K Q+ +YS+ +N++L++ + ++ + ++KE+ + L +L++E
Sbjct: 822 ERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---- 877
Query: 65 RNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHI 124
R +A + L L+ + N ++ QK + D++ Q K++ + L
Sbjct: 878 RTAPVAD-PKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQN-QSKMQLLQSLQE 935
Query: 125 QFFEADE---QHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKL-- 179
Q E DE QH+ + A + E Q ++ + + E + +Q D + +
Sbjct: 936 QKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ 995
Query: 180 --EVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYN 237
+V+S +E +++ L E + +K + E E + ++NEK N + Q +
Sbjct: 996 ETKVQSLNIENGSEKHDLSKAETERLVKGIKE-----RELEIKLLNEK---NISLTKQID 1047
Query: 238 ALNVPLHNRRHQ-LKMRDIAGQAL-------AFVQDLVTALLNFHTYTEQRIQIFPVDSA 289
L+ + Q ++ +D+ QAL + QD+V Y +R ++F V
Sbjct: 1048 QLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAV--- 1104
Query: 290 IDTISPLNQKFSQYLHENASYVRPLEEGMLHL----------FESITED----TVTVLET 335
++ + N H+ V E ++ L FES +D T+ L
Sbjct: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
Query: 336 TVKLKTFSEHLTSYIC-FLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKMTAV 394
++ K S C L +L E +S L +L Q +KKM
Sbjct: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224
Query: 395 FEKLQTYIALLALPSTEPDGLLR----------TNYSSVLTNVGAALHGFHDVMKDISKH 444
+++ T + + S + L N S + + + + +
Sbjct: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF 1284
Query: 445 YSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKA 504
+ A ++H + +L T D +L LD LS
Sbjct: 1285 GQELAQVQHSI----GQLCNTKDLLL------------------GKLDIISPQLS----- 1317
Query: 505 ASGFISPLSAECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQ 564
++ ++P SAEC+ K + + L + LE + ++L + + + + +
Sbjct: 1318 SASLLTPQSAECLRASKSEVLSESSELLQQELEEL--RKSLQEKDATIRTLQENN---HR 1372
Query: 565 VQQSLEKISKLEQEKEHWMLEAQLAKIKLEKEN--QRIADKLKNTGSAQLVGLAQENAAV 622
+ S+ S+LE+ KEH ++++ ++K EK++ Q++ + A+ L N
Sbjct: 1373 LSDSIAATSELER-KEHEQTDSEIKQLK-EKQDVLQKLLKEKDLLIKAKSDQLLSSNENF 1430
Query: 623 SNTAGQDEATAKAV----------------------------------LEPIQSTSL-IG 647
+N ++E +AV + +Q T++
Sbjct: 1431 TNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFS 1490
Query: 648 TLTRTSDSEVPDVESR----EDLIKNHYMARIVELTSQLQLADS---KSVHFYAECRALS 700
+ R + E ++ + E L+K + EL L S K+V F E +
Sbjct: 1491 MMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVM 1550
Query: 701 KRLALAEKSKEALTEEMK-------LASQNISRLQDELTTTKRSYEDQLSMMSDHLCSMN 753
L + AL E++ ++Q + RL++ L ++ SY + D +
Sbjct: 1551 LALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLR 1610
Query: 754 ETLSKQREEIDTLKMSSKGNSKKNKS 779
+ ++ E K+ S N+ +N S
Sbjct: 1611 KKVTVLEE-----KLVSSSNAMENAS 1631
Score = 52.0 bits (123), Expect = 2e-06
Identities = 154/783 (19%), Positives = 299/783 (38%), Gaps = 127/783 (16%)
Query: 1 MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQE-M 59
+ +L+ K + L + +K + N V Q + LKE ++ ++ L +++ E M
Sbjct: 576 LTKQKLEDKVENLVDQLNKSQESN-------VSIQKENLELKEHIRQNEEELSRIRNELM 628
Query: 60 DSL------TFRNLQLAKR-VELLQDELALSE-PRGKKNKKSGESSSQLSQEQKSVFDED 111
SL F++ L +R E+ + LSE + +N K ++ E+ + ED
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 112 LQKKIEE----NERLHIQFFEADEQHK----HVEAELRSRLATLETEAAQHQAVVDGLTR 163
++ ++EE N +L ++ E K +EAEL L EA +++ ++ L+
Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSN 748
Query: 164 KYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEES---LS 220
LQ + L +Q + E E + E+ K + LS LEE
Sbjct: 749 ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 221 IINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQR 280
+IN+K F + + + L L L+ +I Q + E++
Sbjct: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTI-----------------EEK 851
Query: 281 IQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTV-KL 339
D ++ ++ N +L E +R + + + T D+VT L + V +L
Sbjct: 852 ------DRSLGSMKEEN----NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL 901
Query: 340 KTFSEHLTSYICFLRKILPYQ-------LKSLEEE--------CESSLCTSALRARNLEL 384
T EHL I +KI+ Q L+SL+E+ + + LE
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 385 SQDMKKMTAVFEKLQTYI--ALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDIS 442
+++K + E+++T + + + D T S+ G+ H D+S
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKH-------DLS 1014
Query: 443 KHYSQ---KAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLS 499
K ++ K E EL KL+ + ++LT +++ L I
Sbjct: 1015 KAETERLVKGIKERELEI---KLLNEKN------ISLTKQIDQLSKDEVGKLTQIIQQKD 1065
Query: 500 YGPKAASGFISPLS-AECMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESR 558
+A IS S + ++ +++ AY K +L T
Sbjct: 1066 LEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF-------------AVLNEKTREN 1112
Query: 559 EGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQE 618
L + + ++ ++ E A IKL+ EN++++ + +++G Q
Sbjct: 1113 SHLKTEYHKMMDIVAAKE-----------AALIKLQDENKKLSTRFESSGQDMFRETIQN 1161
Query: 619 NAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESR--EDLIKNHYMARIV 676
+S + + A+ + Q T L T ++ +E V S E+L++
Sbjct: 1162 ---LSRIIREKDIEIDALSQKCQ-TLLAVLQTSSTGNEAGGVNSNQFEELLQER-----D 1212
Query: 677 ELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKR 736
+L Q++ + + + A ++ L ++ + S N S+LQ + T +
Sbjct: 1213 KLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQ 1272
Query: 737 SYE 739
SYE
Sbjct: 1273 SYE 1275
Score = 45.4 bits (106), Expect = 2e-04
Identities = 108/618 (17%), Positives = 245/618 (39%), Gaps = 61/618 (9%)
Query: 16 EYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVEL 75
E ++ AQ+ +++ +QA S A E ++ L L Q+ +SL NL+L R+E+
Sbjct: 373 EKERILAQSASVEEVFRLQQALSDAENEIMR-----LSSLNQD-NSLAEDNLKLKMRIEV 426
Query: 76 LQDELALSEPRGKKNKKS------------GESSSQLSQEQK--------SVFDEDLQKK 115
L+ E +L ++ + S ++ +S + + +++L +
Sbjct: 427 LEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQS 486
Query: 116 IEENERLHIQFFEADEQHKHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQND 175
I E E L + E D Q++ E + ++ + ++ Q D + K + + +
Sbjct: 487 ISEKETLIAEIEELDRQNQ----EATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKR 542
Query: 176 KAKLEVKSQTLEKEAKECRLRTEECQLQLKTLH---EDLSGRLEESLSIINEKVPFNDTK 232
+LE + KE + + + ++ L LH + L ++E + +N+ N +
Sbjct: 543 VHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVS- 601
Query: 233 YSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDT 292
Q L + H R+++ ++ I + + + + E+ ++ + +
Sbjct: 602 -IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE 660
Query: 293 ISPLNQKFSQYLH----ENASYVRPLEEGMLHLFESITEDTVTVLETTV---KLKTFSEH 345
+ LN+ + EN V E+ L E + + LE LK
Sbjct: 661 LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE 720
Query: 346 LTSYICFLRKILPYQLKSLEEECES-----SLCTSALRARNLELSQDMKKMTAVFEKLQT 400
+ + +C+ +K L + E+ E +L TSAL+ + L + +K +L+
Sbjct: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 401 YIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELPTATQ 460
I + E +L SS L + I K + + ++ EL +Q
Sbjct: 781 NIEQMDTDHKETKDVL----SSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQ 836
Query: 461 KLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQY 520
L N+ + ++ G + +N+L + L + P + + + +
Sbjct: 837 AL-RKNEILRQTIEEKDRSLGSMKE-ENNHLQEELERLREEQSRTAPVADPKTLDSVTEL 894
Query: 521 KKKAAAYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKE 580
+ + + ++++ L E + + +++I+ +S+ L Q +Q+ +++ E +
Sbjct: 895 ASE-VSQLNTIKEHLEEEIKH-----HQKIIEDQNQSKMQLLQSLQEQKKEMD--EFRYQ 946
Query: 581 HWMLEAQLAKIKLEKENQ 598
H + A ++ LEK+ +
Sbjct: 947 HEQMNATHTQLFLEKDEE 964
Score = 33.5 bits (75), Expect = 0.78
Identities = 54/229 (23%), Positives = 101/229 (44%), Gaps = 27/229 (11%)
Query: 20 LRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRK--LQQEMDSLTFRNLQLAKRVELLQ 77
LR++N+ LKK D + A + Q+K + S R Q+E++ + Q+A + +LL+
Sbjct: 64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLK 123
Query: 78 -DELALSEPRGKKNKKSGESSS---QLSQEQKSVFDEDLQ-----KKIEENERL--HIQF 126
A S P G + SSS +S + D+D+ +E RL +
Sbjct: 124 LQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSR 183
Query: 127 FEADEQH-KHVEAELRSRLA--TLETEAAQHQAVVDGLTRKYMETIEKLQND-------- 175
E++ H +H+ +++ + ++E + Q ++ L + + I+ Q++
Sbjct: 184 LESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH 243
Query: 176 KAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINE 224
+ KL S+ +E + R EE + L + SG +E LS I E
Sbjct: 244 QQKLTEISRRHREELSDYEERIEELE---NLLQQGGSGVIETDLSKIYE 289
Score = 32.0 bits (71), Expect = 2.3
Identities = 38/192 (19%), Positives = 78/192 (40%), Gaps = 28/192 (14%)
Query: 563 QQVQQSLEKISKLEQEKEHWMLEAQLAKIK-LEKENQRIADKLKNTGSAQLVGLAQENAA 621
Q++ + ++S+LE E HW AQ +K + + +Q KL+N +QE
Sbjct: 172 QEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEI-- 229
Query: 622 VSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHY---------- 671
D +VL+ L ++R E+ D E R + ++N
Sbjct: 230 ------DDHQHEMSVLQNAHQQKLT-EISRRHREELSDYEERIEELENLLQQGGSGVIET 282
Query: 672 -MARIVELTSQLQL-------ADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQN 723
+++I E+ +Q+ + K + + ++K+L+ AE ++ L E + +
Sbjct: 283 DLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVE 342
Query: 724 ISRLQDELTTTK 735
++ +E K
Sbjct: 343 KRQIMEECENLK 354
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 62.0 bits (149), Expect = 2e-09
Identities = 86/416 (20%), Positives = 186/416 (44%), Gaps = 35/416 (8%)
Query: 2 ASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDS 61
AS+E + + +KL Q+ Q + L+ E + ++++ +L+ ++ L LQ+ +
Sbjct: 736 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 795
Query: 62 LTFRNLQLAKRVELLQDELA-LSEPRGKKNKKSGESSSQLSQ--EQKSVFDEDLQKKIEE 118
++ L K +++L+++ A SE + E+ ++L Q EQ ++ DL+K E
Sbjct: 796 VSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 855
Query: 119 NERLHIQFFEADEQHKHV-------EAELRSRLATLETEAAQHQAVVDGLTRKYMETIEK 171
+ +F E DE+ + + E ++ + ++Q + D L K + +E+
Sbjct: 856 LADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD-VEE 914
Query: 172 LQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDT 231
LQ K + L+K ++ ++ E+ Q + HE+ LE LS + +K+ +T
Sbjct: 915 LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM---ET 971
Query: 232 KYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAID 291
++Q L R++ + + +Q+L LL+ TE +++ A +
Sbjct: 972 SHNQCQELKA-----RYERATSETKTKHEEILQNLQKTLLD----TEDKLK-----GARE 1017
Query: 292 TISPLNQKFSQYLHENASYVRPLE--EGMLHLFESITEDTVTVLETTVKLKTFSEHLTSY 349
S L Q+ + L + A + + E + + E +T++ L + K + L +
Sbjct: 1018 ENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1076
Query: 350 ICFLRKILPYQLKSLEEECESSLCTSALRARNLELSQDMKKM-TAVFEKLQTYIAL 404
+ L++ LK++EE +S + + E ++++ + A +K Q AL
Sbjct: 1077 LDTLKE---NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL 1129
Score = 57.4 bits (137), Expect = 5e-08
Identities = 166/819 (20%), Positives = 321/819 (39%), Gaps = 119/819 (14%)
Query: 36 ANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKN----- 90
+ + AL+E LK K Q + +L E D + V ++ ELAL+ ++
Sbjct: 348 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELE 407
Query: 91 --------------KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHV 136
++ E +QL +E++ V EDLQ ++EE A K
Sbjct: 408 AKMDQLRTMVEAADREKVELLNQLEEEKRKV--EDLQFRVEEESITKGDLEVATVSEKSR 465
Query: 137 EAELRSRLATLETEAAQHQAVVD-----GLTRKYMETIEKLQNDKAKLEVKSQTLEKEAK 191
EL LA E A+ + ++ G + ++++ + + KLEV ++E
Sbjct: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
Query: 192 ECR----LRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRR 247
+ R E Q ++K L+ E LS NE + ++ N+ + L +
Sbjct: 526 SLKEHFGAREETHQKEIKALYT-----ATEKLSKENESLKSKLEHANKENSDVIALWKSK 580
Query: 248 -------HQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF 300
HQ M ++ ++F + L T F Q I+ +D + + NQ+
Sbjct: 581 LETAIASHQQAMEELK---VSFSKGLGTETAEFAELKTQ-IEKMRLDYQHEIENLQNQQD 636
Query: 301 SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKL-KTFSEHLTSYICFLRKILPY 359
S E A++ + +E L + I E ++ KL K +HL L K+
Sbjct: 637 S----ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 692
Query: 360 QLKSLEEECESSLCTS-----------------------ALRARNLELSQDMKKMTAVFE 396
++K E E + C ALR + E +MKK+ E
Sbjct: 693 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 397 KLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAAIEHELP 456
+ I L + + SS+ + ++ +++S+ K +E EL
Sbjct: 753 AAEKQIKHLEIEKNAES----SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 808
Query: 457 TATQKLITTNDCILSSVVALTNGAGKIA------SFFSNNLDYFIASLSYGPKAASGFIS 510
+K ++ +S ++ K+ + S++L+ +L+ A
Sbjct: 809 ILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA--DMEAKFREK 866
Query: 511 PLSAECMLQYKKKAAAYMKSLRK------PLLESVPYEEALANR---RILLSSTESREGL 561
E +++ K+K + + K L + E L R + L T++ E
Sbjct: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN- 925
Query: 562 AQQVQQSLEKIS-KLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQLVGLAQENA 620
A +Q+S+E ++ K EQ ++ + + K +LE++ + K++ + + A+
Sbjct: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 621 AVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARIVELTS 680
A S T + E +L+ +Q T L D+E +RE+ + + + EL
Sbjct: 986 ATSETKTKHEE----ILQNLQKTLL--------DTEDKLKGAREE--NSGLLQELEELRK 1031
Query: 681 QLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSY-- 738
Q A K+ + + +++ + A E+ K Q ++LQ+EL T K +
Sbjct: 1032 QADKA--KAAQTAEDAMQIMEQMTKEKTETLASLEDTK---QTNAKLQNELDTLKENNLK 1086
Query: 739 -EDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKK 776
++L+ + L N+ + + R+EI+TLK ++ S++
Sbjct: 1087 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1125
Score = 55.1 bits (131), Expect = 2e-07
Identities = 56/241 (23%), Positives = 115/241 (47%), Gaps = 13/241 (5%)
Query: 15 QEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVE 74
Q +KL+ + LK+ + KE L +++Q + + ++E+++L Q ++++
Sbjct: 1068 QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1127
Query: 75 LLQDE-LALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQH 133
LQ+E + L+E G+ + +S Q +E++SV + L +E +R +ADE+
Sbjct: 1128 ALQEENVKLAEELGRSRDEV--TSHQKLEEERSVLNNQL---LEMKKRESKFIKDADEE- 1181
Query: 134 KHVEAELRSRLATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAK-LEVKSQTLEKEAKE 192
+A L+ ++ + A ++ L + T+ + +N AK L QTLE + +
Sbjct: 1182 ---KASLQKSISITSALLTEKDAELEKLRNEV--TVLRGENASAKSLHSVVQTLESDKVK 1236
Query: 193 CRLRTEECQLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKM 252
L+ + +LQLK LS + + +E +++ N++ V L + LKM
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKM 1296
Query: 253 R 253
+
Sbjct: 1297 K 1297
Score = 38.5 bits (88), Expect = 0.024
Identities = 132/708 (18%), Positives = 258/708 (36%), Gaps = 107/708 (15%)
Query: 91 KKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELR-------SR 143
K SG ++ Q + ++K + +++ + E + + +A +E EL
Sbjct: 346 KISGTTALQEALKEKQ---QHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQH 402
Query: 144 LATLETEAAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEA---KECRLRTEEC 200
+ LE + Q + +V+ R+ +E + +L+ +K K+E +E+E+ + + T
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462
Query: 201 QLQLKTLHEDLSGRLEESLSIINEKVPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQAL 260
+ ++ L +DL+ R++E + R +L+ AG
Sbjct: 463 KSRIMELEKDLALRVQEVAEL-------------------------RRRLESNKPAGDV- 496
Query: 261 AFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLH 320
D+ +LL IS L +K ++ + L+E
Sbjct: 497 ----DMSLSLL-------------------QEISSLQEKLEVTRTDHQREITSLKEHFGA 533
Query: 321 LFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCT--SALR 378
E+ ++ + T KL +E L S + K + + + E+++ + A+
Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 593
Query: 379 ARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFH-DV 437
+ S+ + TA F +L+T I + L L+ S + +
Sbjct: 594 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 653
Query: 438 MKDISKHYSQKAAIEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIAS 497
MK I + + AI +L A + + + L+ + + A L+ A
Sbjct: 654 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL--------QEAEIKVKELEVLQAK 705
Query: 498 LSYGPKAASGFISPLSAE----CMLQYKKKAAAYMKSLRKPLLESVPYEEALANRRILLS 553
+ K F S L A L +KA++ KS K L + + E +
Sbjct: 706 CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 765
Query: 554 STESRE--GLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADKLKNTGSAQ 611
+ ES + + +++Q K++ L++ + E K LEKE Q + +K
Sbjct: 766 NAESSKASSITRELQGRELKLTNLQEN----LSEVSQVKETLEKELQILKEKFAEA---- 817
Query: 612 LVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESR---EDLIK 668
AVS E K + Q L L + ++ + D+E++ +D +
Sbjct: 818 ------SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN-LADMEAKFREKDERE 870
Query: 669 NHYMARIVELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQ 728
+ +L + + S ++ ++ L L E+ E L ++ A++N S LQ
Sbjct: 871 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930
Query: 729 DELTTTKRSYEDQLSMMSDHLCSMNETLSKQREEIDTLKMSSKGNSKK 776
+S ED S E K EE L+ KK
Sbjct: 931 -------KSIEDMTVKAEQ---SQQEAAKKHEEEKKELERKLSDLEKK 968
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,005,779
Number of Sequences: 37866
Number of extensions: 970249
Number of successful extensions: 8355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 725
Number of HSP's that attempted gapping in prelim test: 5034
Number of HSP's gapped (non-prelim): 3333
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.