Search of human proteins with 11342666

Search of human proteins with 11342666

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
[Homo sapiens]
         (660 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...  1414   0.0  
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]     1315   0.0  
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   617   e-176
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   223   4e-58
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    219   8e-57
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      218   2e-56
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   218   2e-56
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   216   5e-56
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   216   5e-56
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   216   7e-56
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    212   1e-54
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   204   3e-52
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   199   9e-51
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    195   1e-49
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   191   2e-48
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   189   7e-48
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   188   1e-47
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   181   2e-45
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                174   2e-43
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   170   4e-42
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   151   2e-36
gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens]      146   7e-35
gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens]      146   7e-35
gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens]      146   7e-35
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]      146   7e-35
gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens]      146   7e-35
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]      146   7e-35
gi|47132547 fibronectin 1 isoform 7 preproprotein [Homo sapiens]      146   7e-35
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   137   4e-32
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   132   1e-30

>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score = 1414 bits (3661), Expect = 0.0
 Identities = 660/660 (100%), Positives = 660/660 (100%)

Query: 1   MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC 60
           MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
Sbjct: 1   MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC 60

Query: 61  PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD 120
           PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
Sbjct: 61  PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD 120

Query: 121 KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD 180
           KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
Sbjct: 121 KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD 180

Query: 181 GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN 240
           GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
Sbjct: 181 GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN 240

Query: 241 GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT 300
           GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
Sbjct: 241 GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT 300

Query: 301 SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY 360
           SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
Sbjct: 301 SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY 360

Query: 361 ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL 420
           ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
Sbjct: 361 ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL 420

Query: 421 MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ 480
           MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
Sbjct: 421 MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ 480

Query: 481 IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY 540
           IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
Sbjct: 481 IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY 540

Query: 541 WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP 600
           WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
Sbjct: 541 WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP 600

Query: 601 GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
           GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
Sbjct: 601 GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score = 1315 bits (3404), Expect = 0.0
 Identities = 609/610 (99%), Positives = 610/610 (100%)

Query: 51  VQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY 110
           +QYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY
Sbjct: 1   MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY 60

Query: 111 NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIM 170
           NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIM
Sbjct: 61  NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIM 120

Query: 171 INFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG 230
           INFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG
Sbjct: 121 INFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG 180

Query: 231 EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQP 290
           EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQP
Sbjct: 181 EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQP 240

Query: 291 CKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV 350
           CKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV
Sbjct: 241 CKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV 300

Query: 351 FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG 410
           FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG
Sbjct: 301 FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG 360

Query: 411 LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICK 470
           LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICK
Sbjct: 361 LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICK 420

Query: 471 QDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEE 530
           QDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEE
Sbjct: 421 QDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEE 480

Query: 531 KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR 590
           KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR
Sbjct: 481 KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR 540

Query: 591 YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF 650
           YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF
Sbjct: 541 YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF 600

Query: 651 GSIKSDWLGC 660
           GSIKSDWLGC
Sbjct: 601 GSIKSDWLGC 610


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  617 bits (1591), Expect = e-176
 Identities = 324/704 (46%), Positives = 430/704 (61%), Gaps = 70/704 (9%)

Query: 17  LCLLGCLLSHAAAAPSPIIKFPGDVAPK-TDKELAVQYLNTFYGCPK------ESCNLFV 69
           L +LGC  +      S ++ FPGD+    TD++LA +YL   YG  +      ES +L  
Sbjct: 11  LLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYR-YGYTRVAEMRGESKSL-- 67

Query: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRII 129
               L  +QK   LP+TG+LD  T++ MR PRCG PD+  +  F    KW  + ITY I 
Sbjct: 68  -GPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQ 126

Query: 130 GYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDG 189
            Y+ DL    +DDAFARAF +WS VTPL F+R++  +ADI+I FG  EHGDGYPFDGKDG
Sbjct: 127 NYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDG 186

Query: 190 LLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTD 249
           LLAHAF PG G+ GD+HFDDDELW+LG+G VV  ++GNADG  C FPF+F G+ Y++CT 
Sbjct: 187 LLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTT 246

Query: 250 TGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEG 309
            GRSDG  WCSTT N++ D ++GFCP E L+T  GNA+G+PC+FPF FQG SY +CTT+G
Sbjct: 247 DGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDG 306

Query: 310 RTDGYRWCGTTEDYDRDKKYGFCPETAMSTV-GGNSEGAPCVFPFTFLGNKYESCTSAGR 368
           R+DGYRWC TT +YDRDK +GFCP  A STV GGNS G  CVFPFTFLG +Y +CTS GR
Sbjct: 307 RSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGR 366

Query: 369 SDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT 428
            DG++WCATT+N+D D+KWGFCPDQGYSLFLVAAHEFGHA+GL+HS  P ALM P+Y +T
Sbjct: 367 GDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFT 426

Query: 429 KNFRLSQDDIKGIQELYGASPDID-----------------LGTGP-------TPTLGPV 464
           +   L +DD+ GI+ LYG  P+ +                   TGP        PT GP 
Sbjct: 427 EGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPT 486

Query: 465 TP-------------------------EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTP 499
            P                         + C  +I FD IA+I  +++ FKD   WR    
Sbjct: 487 GPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNI-FDAIAEIGNQLYLFKDGKYWRFSEG 545

Query: 500 R-DKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTS 558
           R  +P GP L+A  WP LP K+D+V+E    +K  FF+G + W+Y+ +++    P+ L  
Sbjct: 546 RGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDK 603

Query: 559 LGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLD 618
           LGL  DV +V  A   S   K  +F+G + WR++   + +DP     +   +  +P  LD
Sbjct: 604 LGLGADVAQVTGALR-SGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVP--LD 660

Query: 619 AVVDLQGGGHSYFFKGAYYLKLENQS-LKSV-KFGSIKSDWLGC 660
                Q    +YF +  +Y ++ ++S L  V + G +  D L C
Sbjct: 661 THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQC 704


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  223 bits (568), Expect = 4e-58
 Identities = 112/258 (43%), Positives = 157/258 (60%), Gaps = 12/258 (4%)

Query: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQD 436
           A++DDD  W     +GY+LFLVAAHEFGH++GL+HS+DPGALM PIYTYT   +F L  D
Sbjct: 199 AHFDDDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDD 257

Query: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
           D++GIQ LYG   +      P P   P TP+ C   +  D I  +RGE   FKDRF WR 
Sbjct: 258 DVQGIQSLYGPGDE-----DPNPK-HPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR- 310

Query: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
           + P+       L  +FWPELP +IDA YE P  +    F G ++W  +   +  GYPK +
Sbjct: 311 LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI 370

Query: 557 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 616
           + LGLP +V+++ AA ++    KT +F+G++ WRY++    MD  +P+LI + +  I D 
Sbjct: 371 SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDK 430

Query: 617 LDAVVDLQGGGHSYFFKG 634
           +DAV   +  G+ YFF G
Sbjct: 431 VDAV--YEKNGYIYFFNG 446



 Score =  212 bits (539), Expect = 1e-54
 Identities = 105/196 (53%), Positives = 131/196 (66%), Gaps = 8/196 (4%)

Query: 25  SHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFY------GCPKESCNLFVLKDTLKKMQ 78
           +H  A P P      D++ + D + A +YL ++Y      G  KE+     + + L++MQ
Sbjct: 15  THCRALPLPSGGDEDDLSEE-DLQFAERYLRSYYHPTNLAGILKENA-ASSMTERLREMQ 72

Query: 79  KFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPE 138
            FFGL  TG LD NT++ M+KPRCG PDV  YN FPR  KW K  +TYRI+ YTPD+   
Sbjct: 73  SFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHS 132

Query: 139 TVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPG 198
            V+ AF +AF+VWSDVTPL F+R+HDG ADIMI+FG  EHGD YPFDG  GLLAHAF PG
Sbjct: 133 EVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPG 192

Query: 199 TGVGGDSHFDDDELWT 214
              GGD+HFDDDE WT
Sbjct: 193 PNYGGDAHFDDDETWT 208


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  219 bits (557), Expect = 8e-57
 Identities = 119/289 (41%), Positives = 166/289 (57%), Gaps = 13/289 (4%)

Query: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQ 435
           A++DDD +W      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQ
Sbjct: 195 AHFDDDEQWTK-DTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQ 253

Query: 436 DDIKGIQELYGASPDID----LGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDR 491
           DDI GIQ LYG  PD      + T P P   P TP  C   + FD ++ +RGEI  FKDR
Sbjct: 254 DDINGIQSLYGPPPDSPETPLVPTEPVPP-EPGTPANCDPALSFDAVSTLRGEILIFKDR 312

Query: 492 FIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERG 551
             WR    + +P   L +++FWP LP  +DA YE   ++    F GN++W    + +  G
Sbjct: 313 HFWRKSLRKLEPELHL-ISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAG 371

Query: 552 YPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWN 611
           YP+ + +LG PP V+++DAA +  +  KTY F  DK+WR++E +  M+PGFPK IA+ + 
Sbjct: 372 YPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFP 431

Query: 612 AIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
            I   +DAV   +  G  YFF G+  L+ +  + K V      + WL C
Sbjct: 432 GIDSKIDAV--FEEFGFFYFFTGSSQLEFD-PNAKKVTHTLKSNSWLNC 477



 Score =  199 bits (505), Expect = 9e-51
 Identities = 93/176 (52%), Positives = 118/176 (67%), Gaps = 6/176 (3%)

Query: 45  TDKELAVQYLNTFYGCPKESCNLFVLKDT------LKKMQKFFGLPQTGDLDQNTIETMR 98
           T   L  +YL  +Y   K+       KD+      +++MQKF GL  TG LD +T+E MR
Sbjct: 29  TSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMR 88

Query: 99  KPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLR 158
           KPRCG PDV ++  FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL 
Sbjct: 89  KPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLT 148

Query: 159 FSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
           FSR+++GEADIMI+F   EHGD YPFDG   +LAHA+APG G+ GD+HFDDDE WT
Sbjct: 149 FSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT 204


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  218 bits (554), Expect = 2e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 379 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 436
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 129 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 185

Query: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 186 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 239

Query: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 240 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298

Query: 557 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 615
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358

Query: 616 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 359 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 400



 Score =  170 bits (431), Expect = 3e-42
 Identities = 76/138 (55%), Positives = 99/138 (71%)

Query: 77  MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLD 136
           MQ+FFGL  TG  D  T++ M++PRCG PDVA +      P+W++  +TYRI  YTPDL 
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 137 PETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFA 196
              VD A  +AFQ+WS+VTPL F+++ +G+ADIMI+F R +H D  PFDG  G LAHAF 
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 197 PGTGVGGDSHFDDDELWT 214
           PG G+GGD+HFD+DE WT
Sbjct: 121 PGPGIGGDAHFDEDERWT 138


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  218 bits (554), Expect = 2e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 379 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 436
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251

Query: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 252 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 305

Query: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 306 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364

Query: 557 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 615
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 424

Query: 616 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 425 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 466



 Score =  177 bits (449), Expect = 3e-44
 Identities = 84/175 (48%), Positives = 114/175 (65%), Gaps = 6/175 (3%)

Query: 46  DKELAVQYLNTFYGCPKESC------NLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRK 99
           D +L  +YL  +Y    +        N   + + LK+MQ+FFGL  TG  D  T++ M++
Sbjct: 30  DVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQ 89

Query: 100 PRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRF 159
           PRCG PDVA +      P+W++  +TYRI  YTPDL    VD A  +AFQ+WS+VTPL F
Sbjct: 90  PRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149

Query: 160 SRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
           +++ +G+ADIMI+F R +H D  PFDG  G LAHAF PG G+GGD+HFD+DE WT
Sbjct: 150 TKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  216 bits (550), Expect = 5e-56
 Identities = 128/317 (40%), Positives = 167/317 (52%), Gaps = 41/317 (12%)

Query: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L  
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280

Query: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 466
           DD++GIQ++YG    I   T P PT+ P                               P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340

Query: 467 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEA 526
            IC  D  F+ +A +R E+F FKD++ WR    R     P+ +  FW  LP  IDAVYE 
Sbjct: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYEN 398

Query: 527 PQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGD 586
             +   VFF GN+YW++  +TL+ GYP  L +LG       +D+A  W    KTY F GD
Sbjct: 399 -SDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGD 457

Query: 587 KFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLK 646
           ++WRY+E  K MDPG+PK I   W  IP++       +  G +YF+KG  Y K  NQ LK
Sbjct: 458 RYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILK 516

Query: 647 SVKFG---SIKSDWLGC 660
            V+ G   SI  D++GC
Sbjct: 517 -VEPGYPRSILKDFMGC 532



 Score =  137 bits (344), Expect = 4e-32
 Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)

Query: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 120
           ++  L  MQ+F+G+  TG +D+NTI+ M+KPRCG PD    +  F  R+        KW 
Sbjct: 69  MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128

Query: 121 KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 172
              ITY I   TP + DPET   A  RAF VW +VTPL F     S + +G  + DI I 
Sbjct: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187

Query: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216
           F    HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  216 bits (550), Expect = 5e-56
 Identities = 127/318 (39%), Positives = 169/318 (53%), Gaps = 42/318 (13%)

Query: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L Q
Sbjct: 257 HFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQ 316

Query: 436 DDIKGIQELYGASPDIDLGTGPTPTLG--------------------------PVTP--- 466
           DD++GIQ++YG   +    T P PTL                           P TP   
Sbjct: 317 DDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTK 376

Query: 467 -EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 525
             IC  D  F+ +A  RGE+F FKDR+ WR    R +   P+ +  FW  LP +IDA YE
Sbjct: 377 PNIC--DGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYE 434

Query: 526 APQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAG 585
              + + VFF G++YW++   T+E GYP  L  LG     + +D A  W    KTY F G
Sbjct: 435 RA-DGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKG 493

Query: 586 DKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSL 645
           +++WRY+E ++  DPG+PK I   W  IP         + G ++YF+KG  Y K +NQ L
Sbjct: 494 ERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKL 552

Query: 646 KSVKFG---SIKSDWLGC 660
            SV+ G   +I  DW+GC
Sbjct: 553 -SVEPGYPRNILRDWMGC 569



 Score =  144 bits (363), Expect = 3e-34
 Identities = 77/161 (47%), Positives = 93/161 (57%), Gaps = 14/161 (8%)

Query: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA-------NYNFFPRKPKWDKN 122
           L+  +  MQ+F+G+P TG LDQ TIE M+KPRCG PD         N  +     KW + 
Sbjct: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166

Query: 123 QITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--HD-----GEADIMINFGR 175
            ITY I  YTP +       A  +AF VW  VTPL F  +  H+      EADIMI F  
Sbjct: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226

Query: 176 WEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216
             HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 227 GFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 267


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  216 bits (549), Expect = 7e-56
 Identities = 118/287 (41%), Positives = 165/287 (57%), Gaps = 11/287 (3%)

Query: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQD 436
           ++DDD KW      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQD
Sbjct: 195 HFDDDEKWTE-DASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253

Query: 437 DIKGIQELYGASP-DIDLGTGPTPTL--GPVTPEICKQDIVFDGIAQIRGEIFFFKDRFI 493
           D+ GIQ LYG  P   +    PT ++  G   P  C   + FD I+ +RGE  FFKDR+ 
Sbjct: 254 DVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYF 313

Query: 494 WRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYP 553
           WR      +P   L+ A FWP LP  +DA YE    +    F GNE+W    + ++ GYP
Sbjct: 314 WRRSHWNPEPEFHLISA-FWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYP 372

Query: 554 KPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAI 613
           + + +LG PP ++++DAA +  + KKTY FA DK+WR++E  + M+ GFP+LIAD +  +
Sbjct: 373 RGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGV 432

Query: 614 PDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
              +DAV  LQ  G  YFF G+   + +  + + V      + WL C
Sbjct: 433 EPKVDAV--LQAFGFFYFFSGSSQFEFD-PNARMVTHILKSNSWLHC 476



 Score =  193 bits (491), Expect = 4e-49
 Identities = 95/177 (53%), Positives = 119/177 (67%), Gaps = 9/177 (5%)

Query: 45  TDKELAVQYLNTFYGCPKE-------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETM 97
           ++K+LA QYL  +Y   K+         NL V K  ++ MQKF GL  TG LD +T+E M
Sbjct: 29  SNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKK--IQGMQKFLGLEVTGKLDTDTLEVM 86

Query: 98  RKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPL 157
           RKPRCG PDV +++ FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL
Sbjct: 87  RKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPL 146

Query: 158 RFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
            FSR+++GEADIMI+F   EHGD Y FDG    LAHA+ PG G+ GD HFDDDE WT
Sbjct: 147 TFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT 203


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  212 bits (539), Expect = 1e-54
 Identities = 116/284 (40%), Positives = 157/284 (55%), Gaps = 15/284 (5%)

Query: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQD 436
           A++D +  W       Y+LFLVAAHEFGH++GL HS DPGALM P Y +  T N+ L QD
Sbjct: 194 AHFDAEETWTNT-SANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQD 252

Query: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
           DI GIQ +YG      L + P    GP TP+ C   + FD I  +RGEI FFKDR+ WR 
Sbjct: 253 DIDGIQAIYG------LSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRR 306

Query: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
             P+ + +    ++ FWP LP  I A YE    +    F GN+YW  S   + +GYPK +
Sbjct: 307 -HPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI 365

Query: 557 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 616
           ++ G P  VQ +DAA  +    KTY F  D+FWRY+  ++ M+PG+PK I+ A+  I   
Sbjct: 366 SNYGFPSSVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESK 423

Query: 617 LDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660
           +DAV   +   H +     Y   L  Q +  V  G   + WL C
Sbjct: 424 VDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARG---NKWLNC 464



 Score =  169 bits (428), Expect = 7e-42
 Identities = 87/186 (46%), Positives = 112/186 (60%), Gaps = 11/186 (5%)

Query: 37  FPGDVAPKTDKELAVQYLNTFYGCP--------KESCNLFVLKDTLKKMQKFFGLPQTGD 88
           FP     K  K +   YL  FY  P        K   N+ V K  LK+MQ+FFGL  TG 
Sbjct: 21  FPVSSKEKNTKTVQ-DYLEKFYQLPSNQYQSTRKNGTNVIVEK--LKEMQRFFGLNVTGK 77

Query: 89  LDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAF 148
            ++ T++ M+KPRCG PD   +   P  PKW++  +TYRI  YTP L    V+ A   AF
Sbjct: 78  PNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAF 137

Query: 149 QVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFD 208
           ++WS  +PL F+RI  GEADI I F + +HGD  PFDG +G+LAHAF PG G+GGD+HFD
Sbjct: 138 ELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFD 197

Query: 209 DDELWT 214
            +E WT
Sbjct: 198 AEETWT 203


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  204 bits (518), Expect = 3e-52
 Identities = 119/330 (36%), Positives = 163/330 (49%), Gaps = 53/330 (16%)

Query: 380 NYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
           ++D D  W F      G +LFLVA HE GHA+GLEHS +P A+MAP Y +    NF+L +
Sbjct: 234 HFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPE 293

Query: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-------------------------------- 463
           DD++GIQ+LYG        T P PT+ P                                
Sbjct: 294 DDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPP 353

Query: 464 -----------VTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATF 512
                        P IC  D  FD +A +RGE+F FK R+ WR    R     P+ +  F
Sbjct: 354 VQPRATERPDQYGPNICDGD--FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHF 411

Query: 513 WPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAF 572
           W  LP  I A YE  Q+ + VFF G+ YW++  + LE GYP+PLTS GL     R+D A 
Sbjct: 412 WRGLPGDISAAYER-QDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI 470

Query: 573 NWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFF 632
            W     T+ F  D++WR+NE  ++ DPG+PK I+  W  IP +           ++YF+
Sbjct: 471 WWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAAYTYFY 529

Query: 633 KGAYYLKLENQSLKSVKF--GSIKSDWLGC 660
           KG  Y K +N+ L+       SI  D++GC
Sbjct: 530 KGTKYWKFDNERLRMEPGYPKSILRDFMGC 559



 Score =  128 bits (321), Expect = 2e-29
 Identities = 70/165 (42%), Positives = 90/165 (54%), Gaps = 19/165 (11%)

Query: 69  VLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV----ANYNFFPRKP------- 117
           +L   L +MQ+F+G+P TG LD+ T E M++PRCG PD        N   R+        
Sbjct: 78  ILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGR 137

Query: 118 KWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADI 169
           KW+ + +T+ I  YT  L      +A  RAF+VW   TPL F  +           EADI
Sbjct: 138 KWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADI 197

Query: 170 MINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
           M+ F    HGD  PFDG  G LAHA+ PG G+GGD+HFD DE WT
Sbjct: 198 MVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWT 242


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  199 bits (505), Expect = 9e-51
 Identities = 114/282 (40%), Positives = 156/282 (55%), Gaps = 18/282 (6%)

Query: 394 GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQDDIKGIQELYGASPDI 451
           G  +FLVA HE GHA+GLEHS DP A+MAP Y +  T+NF L  DD +GIQ+LYG     
Sbjct: 230 GNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGF 289

Query: 452 DLGTGPTP--TLGPVTPEICKQ--------DIVFDGIAQIRGEIFFFKDRFIWRTVTPRD 501
                P P  T  P  P+  K         D  FD +A +RGE+F FK+R+ WR    + 
Sbjct: 290 PTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQV 349

Query: 502 KPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGL 561
               P+ +  FW  LP  I+  YE  ++ K VFF G+++W++  ++LE GYPK +  LG 
Sbjct: 350 MDGYPMPIGQFWRGLPASINTAYER-KDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGR 408

Query: 562 PPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVV 621
                ++DAA  W  N KTY F G+K++R+NE  + +D  +PK I   W  IP++     
Sbjct: 409 GLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSF 467

Query: 622 DLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKS---DWLGC 660
                  +YF+KG  Y K  NQ LK V+ G  KS   DW+GC
Sbjct: 468 MGSDEVFTYFYKGNKYWKFNNQKLK-VEPGYPKSALRDWMGC 508



 Score =  135 bits (339), Expect = 2e-31
 Identities = 69/163 (42%), Positives = 91/163 (55%), Gaps = 17/163 (10%)

Query: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD---------VANYNFFPRKPKWD 120
           L   +  MQKF+GL  TG  D +T++ MR+PRCG PD         V    +  +  KW 
Sbjct: 61  LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ 120

Query: 121 KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADIMIN 172
            N+IT+ I  YTP +      +A  +AF+VW   TPLRF  +        H+ +ADIMI 
Sbjct: 121 HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF 180

Query: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTL 215
           F    HGD  PFDG+ G LAHA+ PG  +GGD+HFD  E WT+
Sbjct: 181 FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV 223


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  195 bits (495), Expect = 1e-49
 Identities = 104/212 (49%), Positives = 127/212 (59%), Gaps = 4/212 (1%)

Query: 14  LRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDT 73
           L  LC + CLL  + A P P  +  G ++ +   E A  YL  FY    E+ N   L+  
Sbjct: 3   LTVLCAV-CLLPGSLALPLP--QEAGGMS-ELQWEQAQDYLKRFYLYDSETKNANSLEAK 58

Query: 74  LKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTP 133
           LK+MQKFFGLP TG L+   IE M+KPRCG PDVA Y+ FP  PKW    +TYRI+ YT 
Sbjct: 59  LKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTR 118

Query: 134 DLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAH 193
           DL   TVD   ++A  +W    PL F ++  G ADIMI F R  HGD YPFDG    LAH
Sbjct: 119 DLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAH 178

Query: 194 AFAPGTGVGGDSHFDDDELWTLGEGQVVRVKY 225
           AFAPGTG+GGD+HFD+DE WT G    +   Y
Sbjct: 179 AFAPGTGLGGDAHFDEDERWTDGSSLGINFLY 210



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 40/98 (40%), Positives = 54/98 (55%), Gaps = 7/98 (7%)

Query: 351 FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG 410
           +PF   GN      + G   G       A++D+D +W      G +    A HE GH++G
Sbjct: 167 YPFDGPGNTLAHAFAPGTGLGG-----DAHFDEDERWTDGSSLGINFLYAATHELGHSLG 221

Query: 411 LEHSQDPGALMAPIYTY--TKNFRLSQDDIKGIQELYG 446
           + HS DP A+M P Y     +NF+LSQDDIKGIQ+LYG
Sbjct: 222 MGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYG 259


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  191 bits (485), Expect = 2e-48
 Identities = 108/290 (37%), Positives = 156/290 (53%), Gaps = 22/290 (7%)

Query: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQD 436
           A++D+D  W      G +LFL A HE GH++GL HS DP A+M P Y Y     FRLS D
Sbjct: 195 AHFDEDEFWT-THSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSAD 253

Query: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496
           DI+GIQ LYG   +      P  +     P +C  ++ FD +  +  +IFFFKDRF W  
Sbjct: 254 DIRGIQSLYGDPKENQRLPNPDNS----EPALCDPNLSFDAVTTVGNKIFFFKDRFFWLK 309

Query: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556
           V+ R K     L+++ WP LP  I+A YE     +   F  ++YW+ S    E  YPK +
Sbjct: 310 VSERPKT-SVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSI 368

Query: 557 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 616
            S G P  V+++DAA    +  +TY F  +++WRY+E ++ MDPG+PKLI   +  I   
Sbjct: 369 HSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPK 428

Query: 617 LDAVVDLQGGGHSYFFKGA------YYLKLENQSLKSVKFGSIKSDWLGC 660
           +DAV       + YFF+G+      + L+   ++LKS       + W GC
Sbjct: 429 IDAVF-YSKNKYYYFFQGSNQFEYDFLLQRITKTLKS-------NSWFGC 470



 Score =  187 bits (474), Expect = 3e-47
 Identities = 92/176 (52%), Positives = 118/176 (67%), Gaps = 11/176 (6%)

Query: 52  QYLNTFYGCP---------KESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRC 102
           +YL  FYG           K S NL  +K+ +++MQ F GL  TG LD +T+E M  PRC
Sbjct: 35  RYLEKFYGLEINKLPVTKMKYSGNL--MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRC 92

Query: 103 GNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI 162
           G PDV ++   P  P W K+ ITYRI  YTPD++ E VD A  +AFQVWS+VTPL+FS+I
Sbjct: 93  GVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKI 152

Query: 163 HDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEG 218
           + G ADI++ F R  HGD + FDGK G+LAHAF PG+G+GGD+HFD+DE WT   G
Sbjct: 153 NTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSG 208


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  189 bits (480), Expect = 7e-48
 Identities = 98/202 (48%), Positives = 122/202 (60%), Gaps = 13/202 (6%)

Query: 24  LSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPK---------ESCNLFVLKDTL 74
           L  + AAPS +   P     + +  LA  YL+ +Y   +            N  + K  +
Sbjct: 17  LKFSTAAPSLVAASPRTW--RNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRK--I 72

Query: 75  KKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPD 134
           K++Q FFGL  TG LDQ T+  ++KPRCG PDVANY  FP +PKW KN +TYRI  YTP 
Sbjct: 73  KELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPS 132

Query: 135 LDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHA 194
           +    VD A   A Q WS   PL F RI+ GEADIMI+F   +HGD YPFDG  G LAHA
Sbjct: 133 MSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHA 192

Query: 195 FAPGTGVGGDSHFDDDELWTLG 216
           FAPG G+GGD+HFD+ E WT+G
Sbjct: 193 FAPGEGLGGDTHFDNAEKWTMG 214



 Score =  184 bits (468), Expect = 2e-46
 Identities = 107/289 (37%), Positives = 154/289 (53%), Gaps = 17/289 (5%)

Query: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTK--NFRLSQDD 437
           ++D+  KW    + G++LF VAAHEFGHA+GL HS DP ALM P Y Y     F L +DD
Sbjct: 204 HFDNAEKWTMGTN-GFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDD 262

Query: 438 IKGIQELYGASPDIDLGTGPT----PTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFI 493
           +KGIQ LYG    + LG  PT    P   P  P++C     FD +  +  E+  FKDR  
Sbjct: 263 VKGIQALYGPRK-VFLGK-PTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIF 320

Query: 494 WRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYP 553
           WR        + P  + + +P+L   +DA YE  +   A FF G  YWI     ++ G P
Sbjct: 321 WRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQ-GPP 379

Query: 554 KPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAI 613
           + +   G P  VQ++DAA    + +KT  F GD+++ Y+E K+KM+  +PK   + ++ +
Sbjct: 380 RTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGV 439

Query: 614 PDNLDAVVDLQGGGHSYFFKG--AYYLKLENQSLKSVKFGSIKSDWLGC 660
              +DA V+L   G+ YFF G   Y    E + + SV      S W+GC
Sbjct: 440 NGQIDAAVEL--NGYIYFFSGPKTYKYDTEKEDVVSV---VKSSSWIGC 483


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  188 bits (478), Expect = 1e-47
 Identities = 114/312 (36%), Positives = 164/312 (52%), Gaps = 42/312 (13%)

Query: 380 NYDDDRKWGFCPD--QGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT----KNFRL 433
           ++DD+  W F     +G  LF VA HEFGHA+GL HS  P ++M P Y         +RL
Sbjct: 208 HFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRL 267

Query: 434 SQDDIKGIQELYGASPDID--------LGTGPTPTLGPV------TPEICKQDIVFDGIA 479
           SQDD  G+Q+LYG +P           L   P P   P        P+ C+ +  FD IA
Sbjct: 268 SQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGN--FDAIA 325

Query: 480 QIRGEIFFFKDRFIWRT------VTPRDKPMGPLLVATFWPELPEKI---DAVYEAPQEE 530
            IRGE FFFK  + WR       V+PR     P  +  FW  LP ++    A Y   ++ 
Sbjct: 326 NIRGETFFFKGPWFWRLQPSGQLVSPR-----PARLHRFWEGLPAQVRVVQAAYARHRDG 380

Query: 531 KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR 590
           + + F+G ++W++    LE G  +PLT LGLPP  + VDA F+W +N KTY+  G ++WR
Sbjct: 381 RILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWR 438

Query: 591 YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF 650
           Y+E   + DPG+P+ ++  W   P + D V  +   G +YFFKGA+Y +    S+K+   
Sbjct: 439 YDEAAARPDPGYPRDLS-LWEGAPPSPDDVT-VSNAGDTYFFKGAHYWRFPKNSIKTEPD 496

Query: 651 G--SIKSDWLGC 660
               +  +WL C
Sbjct: 497 APQPMGPNWLDC 508



 Score =  129 bits (323), Expect = 1e-29
 Identities = 83/217 (38%), Positives = 110/217 (50%), Gaps = 17/217 (7%)

Query: 14  LRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDT 73
           LR L LL  LL+  A AP P  +   DV+   D      YL   +    +  +   L+D 
Sbjct: 5   LRLLALLLLLLAPPARAPKPSAQ---DVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDA 61

Query: 74  LKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPK--------WDKNQIT 125
           +K MQ+F GLP+TG +D  T+ TMRKPRC  PDV       R+ +        W K  +T
Sbjct: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121

Query: 126 YRIIGY--TPDLDPETVDDAFARAFQVWSDVTPLRFSRI---HDGEADIMINFGRWEHGD 180
           +R+  +  +  L  ETV    + A   W   + L F  +      E DI+I+F R  H D
Sbjct: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181

Query: 181 GYPFDGKDGLLAHAFAPGT-GVGGDSHFDDDELWTLG 216
            YPFDG  G LAHAF PG   + GD+HFDD+E WT G
Sbjct: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFG 218


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  181 bits (459), Expect = 2e-45
 Identities = 109/309 (35%), Positives = 155/309 (50%), Gaps = 28/309 (9%)

Query: 376 ATTANYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKN--- 430
           A   ++DDD  W F      G  LF VA HEFGHA+GL H     ++M P Y        
Sbjct: 219 AGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPL 278

Query: 431 -FRLSQDDIKGIQELYGASPDIDLGTGPT-PTLGPVTPEIC-----KQDIV------FDG 477
            + L  +D   + +LYG    +     P  P L P  P+       ++D+       FD 
Sbjct: 279 RYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDA 338

Query: 478 IAQIRGEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELP---EKIDAVYEAPQEEKAV 533
           +AQIRGE FFFK ++ WR    R    + P  +  FW  LP   + +DAVYE   + K V
Sbjct: 339 VAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIV 398

Query: 534 FFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNE 593
           FF G+ YW++  + +E GYP+P++   LPP    +DAAF+W+ N +TY F    +WRY++
Sbjct: 399 FFKGDRYWVFKDNNVEEGYPRPVSDFSLPPG--GIDAAFSWAHNDRTYFFKDQLYWRYDD 456

Query: 594 VKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--G 651
             + MDPG+P   +  W  +P  LD  +    G  SYFF+G  Y K+ +  L+       
Sbjct: 457 HTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQ 514

Query: 652 SIKSDWLGC 660
           S   DWL C
Sbjct: 515 STARDWLVC 523



 Score =  126 bits (317), Expect = 6e-29
 Identities = 81/218 (37%), Positives = 108/218 (49%), Gaps = 24/218 (11%)

Query: 13  PLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKT-DKELAVQYLNTFYGCPKESCNLFVLK 71
           PL  L LL        AAP+P        AP+  D  L V++L+ F   P        L+
Sbjct: 22  PLPLLLLLALGTRGGCAAPAP--------APRAEDLSLGVEWLSRFGYLPPADPTTGQLQ 73

Query: 72  D------TLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA------NYNFFPRKPKW 119
                   +  MQ+F GL  TG LD+ T+  M+ PRC  PD+            P   KW
Sbjct: 74  TQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKW 133

Query: 120 DKNQITYRIIGYTPD--LDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWE 177
           +K  +++R+  +  D  L  +TV      A +VWSD+ PL F  +    ADI I+F + +
Sbjct: 134 NKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKAD 193

Query: 178 HGDGYPFDGKDGLLAHAFAPG-TGVGGDSHFDDDELWT 214
           H DGYPFDG  G +AHAF PG     GD+HFDDDE WT
Sbjct: 194 HNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWT 231


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  174 bits (441), Expect = 2e-43
 Identities = 102/272 (37%), Positives = 144/272 (52%), Gaps = 22/272 (8%)

Query: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQDD 437
           ++D+D  W      G++LFLVAAHEFGHA+GL HS D  ALM P Y     + + LSQDD
Sbjct: 194 HFDEDENWTK-DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDD 252

Query: 438 IKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT- 496
           I GIQ +YG  P       P     P  P  C  D+ FD I   R E+ FFK R +WR  
Sbjct: 253 INGIQSIYGGLPK-----EPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWRIY 307

Query: 497 --VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPK 554
             +T  +      L+A+FWP LP  + A YE P++ K + F    +W+     +   YPK
Sbjct: 308 YDITDVEFE----LIASFWPSLPADLQAAYENPRD-KILVFKDENFWMIRGYAVLPDYPK 362

Query: 555 PLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIP 614
            + +LG P  V+++DAA      +KTY F G   WR++E+ + MD GFP+ +   +  I 
Sbjct: 363 SIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422

Query: 615 DNLDAVVDLQGGGHSYFFKGA----YYLKLEN 642
             +DA    Q  G  +F +G+    Y +K +N
Sbjct: 423 IRVDAA--FQYKGFFFFSRGSKQFEYDIKTKN 452



 Score =  164 bits (414), Expect = 3e-40
 Identities = 87/174 (50%), Positives = 107/174 (61%), Gaps = 9/174 (5%)

Query: 48  ELAVQYLNTFYGCPKE------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPR 101
           +LA  YLN FY    E      S N  ++ D +++MQ FFGL  TG LD NT+E M+ PR
Sbjct: 31  QLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPR 90

Query: 102 CGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSR 161
           CG PDV  Y +    P W K  +TYRII YTPD+    VD+A     +VWS VTPL+F++
Sbjct: 91  CGVPDVGQYGY--TLPGWRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTK 148

Query: 162 IHDGEADIMINFGRWEHGD-GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
           I  G ADIMI F    HG     FDG  G+L HAF PG G+GGD+HFD+DE WT
Sbjct: 149 ISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWT 202


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  170 bits (430), Expect = 4e-42
 Identities = 106/300 (35%), Positives = 148/300 (49%), Gaps = 30/300 (10%)

Query: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIK 439
           ++D D  W    DQG  L  VAAHEFGH +GL+H+    ALM+  YT+     LS DD +
Sbjct: 192 HFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCR 251

Query: 440 GIQELYGAS-PDIDLGTGPTPTLGP---------------VTPEICKQDIVFDGIAQIRG 483
           G+Q LYG   P +   T  TP LGP                 P+ C+    FD ++ IRG
Sbjct: 252 GVQHLYGQPWPTV---TSRTPALGPQAGIDTNEIAPLEPDAPPDACEAS--FDAVSTIRG 306

Query: 484 EIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIY 543
           E+FFFK  F+WR    + +P  P L +  W  LP  +DA +E  Q     FF G +YW+Y
Sbjct: 307 ELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGH-IWFFQGAQYWVY 365

Query: 544 SASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNK-KTYIFAGDKFWRYNEVKKKMDPGF 602
                  G P PLT LGL      V AA  W   K K Y F G  +WR++   +++D   
Sbjct: 366 DGEKPVLG-PAPLTELGLVR--FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422

Query: 603 PKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--GSIKSDWLGC 660
           P+   D W  +P  +DA       G++YF +G  Y K +   +K+++     +  D+ GC
Sbjct: 423 PRRATD-WRGVPSEIDAAFQ-DADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480



 Score =  129 bits (323), Expect = 1e-29
 Identities = 63/132 (47%), Positives = 81/132 (61%), Gaps = 8/132 (6%)

Query: 96  TMRKPRCGNPDVAN--------YNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARA 147
           ++R PRCG PD ++          F     +W+K  +TYRI+ +   L  E V    A A
Sbjct: 74  SLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEA 133

Query: 148 FQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHF 207
            +VWSDVTPL F+ +H+G ADIMI+F R+ HGD  PFDG  G+LAHAF P T   GD HF
Sbjct: 134 LKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHF 193

Query: 208 DDDELWTLGEGQ 219
           D DE WT+G+ Q
Sbjct: 194 DYDETWTIGDDQ 205


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  151 bits (381), Expect = 2e-36
 Identities = 99/297 (33%), Positives = 153/297 (51%), Gaps = 25/297 (8%)

Query: 378 TANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYT-YTKNFRLSQD 436
           + ++D+D  W     +G +L ++AAHE GHA+GL HS+   ALMAP+Y  Y  +F+L  D
Sbjct: 187 SVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPD 246

Query: 437 DIKGIQELYG-ASP--------DIDLGT-GPTPTLGPVTPEICKQDIVFDGIAQIRGEIF 486
           D+ GIQ LYG  SP        + +L T  P PT     P+ C  ++    +   RG+ +
Sbjct: 247 DVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP-RGKTY 305

Query: 487 FFKDRFIWRTVTPRDKPMGPLL-VATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSA 545
            FK  ++W   T  D   GPL  V+  W  LP  +DA   +P+ +   FF G++ W Y  
Sbjct: 306 AFKGDYVW---TVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYIN 362

Query: 546 STLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKL 605
             +  G+PK L  +        +DAA  W  N+K ++F G  +W+++E+ +     +PK 
Sbjct: 363 FKMSPGFPKKLNRV-----EPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKP 417

Query: 606 IADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF--GSIKSDWLGC 660
           I   +  +P+   A +  Q  G  YFFKG  Y +L NQ L+  K    +I  +W+ C
Sbjct: 418 IKGLFTGVPNQPSAAMSWQ-DGRVYFFKGKVYWRL-NQQLRVEKGYPRNISHNWMHC 472



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 64/170 (37%), Positives = 84/170 (49%), Gaps = 9/170 (5%)

Query: 61  PKESCNLFVLKD---TLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNF--FPR 115
           P E  N F  +D    L+  Q+   LP +G LD  T   MR+PRCG  D  N     +  
Sbjct: 41  PLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLL 100

Query: 116 KPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINF-G 174
             +W K  +T+RI+     L P T   A  +AFQ WS+V PL F  +  G ADI ++F G
Sbjct: 101 LGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHG 160

Query: 175 RWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVK 224
           R        FDG   +LAHA  P     G  HFD+DE WT G  + V ++
Sbjct: 161 RQSSYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTEGTYRGVNLR 207


>gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens]
          Length = 2355

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens]
          Length = 2477

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens]
          Length = 2330

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
          Length = 2296

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens]
          Length = 2421

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
          Length = 2176

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|47132547 fibronectin 1 isoform 7 preproprotein [Homo sapiens]
          Length = 657

 Score =  146 bits (368), Expect = 7e-35
 Identities = 70/178 (39%), Positives = 97/178 (54%), Gaps = 16/178 (8%)

Query: 217 EGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPH 276
           E  V +   GN++GE C  PF +NG+ + SCT  GR DG LWCSTT N+E+D KY FC  
Sbjct: 344 ETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTD 403

Query: 277 EALF--TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE 334
             +   T GGN+ G  C FPF +   +Y  CT+EGR D  +WCGTT++YD D+K+GFCP 
Sbjct: 404 HTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPM 463

Query: 335 TAMSTVGGNSEGAPCVFPFTFLGNKYES---------CTSAGRSDGKMWCATTANYDD 383
            A   +   +EG         +G++++          CT  G   G+  C   +   D
Sbjct: 464 AAHEEICTTNEGV-----MYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRD 516



 Score =  145 bits (365), Expect = 2e-34
 Identities = 77/171 (45%), Positives = 97/171 (56%), Gaps = 18/171 (10%)

Query: 244 YNSC-TDTG--RSDGFLWCSTTYNFEKD----GKYGFCPHEALF-TMGGNAEGQPCKFPF 295
           Y  C TD+G   S G  W  T  N +      G    C   A+  T GGN+ G+PC  PF
Sbjct: 305 YGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPF 364

Query: 296 RFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPE--TAMSTVGGNSEGAPCVFPF 353
            + G ++ SCTTEGR DG+ WC TT +Y++D+KY FC +    + T GGNS GA C FPF
Sbjct: 365 TYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPF 424

Query: 354 TFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHE 404
            +  + Y  CTS GR D   WC TT NYD D+K+GFCP        +AAHE
Sbjct: 425 LYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCP--------MAAHE 467


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  137 bits (344), Expect = 4e-32
 Identities = 77/164 (46%), Positives = 97/164 (59%), Gaps = 18/164 (10%)

Query: 70  LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVA--NYNFFPRKP-------KWD 120
           ++  L  MQ+F+G+  TG +D+NTI+ M+KPRCG PD    +  F  R+        KW 
Sbjct: 69  MQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQ 128

Query: 121 KNQITYRIIGYTPDL-DPETVDDAFARAFQVWSDVTPLRF-----SRIHDG--EADIMIN 172
              ITY I   TP + DPET   A  RAF VW +VTPL F     S + +G  + DI I 
Sbjct: 129 HKHITYSIKNVTPKVGDPET-RKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITII 187

Query: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLG 216
           F    HGD  PFDG+ G LAHA+ PG G+GGD+HFD DE WTLG
Sbjct: 188 FASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLG 231



 Score =  116 bits (291), Expect = 6e-26
 Identities = 71/179 (39%), Positives = 89/179 (49%), Gaps = 35/179 (19%)

Query: 380 NYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
           ++D D  W  G     G  LFLVA HE GHA+GLEHS DP A+MAP Y Y  T NF+L  
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280

Query: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-----------------------------VTP 466
           DD++GIQ++YG    I   T P PT+ P                               P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340

Query: 467 EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYE 525
            IC  D  F+ +A +R E+F FKD++ WR    R     P+ +  FW  LP  IDAVYE
Sbjct: 341 NIC--DGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYE 397



 Score = 33.1 bits (74), Expect = 0.84
 Identities = 16/54 (29%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 578 KKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYF 631
           ++ ++F    FWR     + MD G+P  I   W  +P ++DAV +   G   +F
Sbjct: 355 REMFVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  132 bits (331), Expect = 1e-30
 Identities = 64/165 (38%), Positives = 97/165 (58%), Gaps = 2/165 (1%)

Query: 53  YLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNF 112
           Y + F+   KES  L   ++T  ++ + F    T  LD      + +P CG PD ++ + 
Sbjct: 35  YFHQFFLTKKESPLL--TQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSI 92

Query: 113 FPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMIN 172
            P + KW+K+ +TYRII Y  D+ P  V D+   A  +WS+VTPL F ++ +G+ADI ++
Sbjct: 93  SPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVS 152

Query: 173 FGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGE 217
           F +W H DG+PFDG  G+L HAF P +G  G  HFD +E W+  +
Sbjct: 153 FWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASD 197



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 34/76 (44%), Positives = 48/76 (63%), Gaps = 3/76 (3%)

Query: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQDD 437
           ++D +  W    D GY+LFLVA HE GH++GL+HS +  ++M P Y Y   + F+LS DD
Sbjct: 186 HFDKNEHWS-ASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADD 244

Query: 438 IKGIQELYGASPDIDL 453
           I+ IQ LYG     D+
Sbjct: 245 IQRIQHLYGEKCSSDI 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.140    0.458 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,663,174
Number of Sequences: 37866
Number of extensions: 1509896
Number of successful extensions: 2961
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2518
Number of HSP's gapped (non-prelim): 188
length of query: 660
length of database: 18,247,518
effective HSP length: 109
effective length of query: 551
effective length of database: 14,120,124
effective search space: 7780188324
effective search space used: 7780188324
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.