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Search of human proteins with 19923969
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923969 coiled-coil domain containing 124 [Homo sapiens]
(223 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209969700 coiled-coil domain containing 124 [Homo sapiens] 436 e-123
gi|19923969 coiled-coil domain containing 124 [Homo sapiens] 436 e-123
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 57 1e-08
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 57 2e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 51 9e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 51 9e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 49 3e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 4e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 4e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 4e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 49 4e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 49 4e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 49 4e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 49 4e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 49 4e-06
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 48 8e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 47 1e-05
gi|148746195 trichohyalin [Homo sapiens] 47 1e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 47 2e-05
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 46 2e-05
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 46 2e-05
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 46 2e-05
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 46 2e-05
gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Hom... 46 2e-05
gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Hom... 46 2e-05
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom... 46 2e-05
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 45 5e-05
gi|42794779 myosin 18A isoform b [Homo sapiens] 45 5e-05
gi|28416946 myosin 18A isoform a [Homo sapiens] 45 5e-05
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 45 6e-05
>gi|209969700 coiled-coil domain containing 124 [Homo sapiens]
Length = 223
Score = 436 bits (1122), Expect = e-123
Identities = 223/223 (100%), Positives = 223/223 (100%)
Query: 1 MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR 60
MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR
Sbjct: 1 MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR 60
Query: 61 LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA
Sbjct: 61 LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
Query: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ
Sbjct: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
Query: 181 LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK 223
LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK
Sbjct: 181 LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK 223
>gi|19923969 coiled-coil domain containing 124 [Homo sapiens]
Length = 223
Score = 436 bits (1122), Expect = e-123
Identities = 223/223 (100%), Positives = 223/223 (100%)
Query: 1 MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR 60
MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR
Sbjct: 1 MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR 60
Query: 61 LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA
Sbjct: 61 LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
Query: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ
Sbjct: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
Query: 181 LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK 223
LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK
Sbjct: 181 LPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK 223
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 57.0 bits (136), Expect = 1e-08
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 10/185 (5%)
Query: 23 KAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLK 82
K A K +K+ + +D++K +RK + KEE E + DQ ++KE+QR EEE K K
Sbjct: 226 KTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ-SKQKESQRKFEEETVKSK 284
Query: 83 GGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSV 142
V +S+ +A+ D++ D +K K + EE +
Sbjct: 285 VTVDTGVIPASE-EKAETPTAAEDDNE----GDKKKKDKKKKKGEKEEKEKEKKKGPSKA 339
Query: 143 EARTIEDAIAVLSVAEEAADRHPERRMR----AAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
+ +++A+A L EE R E R++ EE +L + K+E + + K+
Sbjct: 340 TVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKE 399
Query: 199 LLKKE 203
LKKE
Sbjct: 400 RLKKE 404
Score = 46.6 bits (109), Expect = 2e-05
Identities = 42/172 (24%), Positives = 89/172 (51%), Gaps = 14/172 (8%)
Query: 3 KKFQGENTKSAAARAR---RAEAKAAADA-KKQKELEDAYWKDDDKHVMRKEQRK-EEKE 57
KK +GE + + + +A KA +A K KE E+ +++++ + R E+ + + KE
Sbjct: 319 KKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE 378
Query: 58 KRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTA 117
+ RL+Q +R+++ Q+ E ++ K GK + S + RA+ E TL+ L +A
Sbjct: 379 EERLEQEKRERKKQKEKERKERLKKEGKL--LTKSQREARARAEATLK----LLQAQGVE 432
Query: 118 EKAKSHL--EVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
+K L + P+ E+ R+ + + +E++ + +++ + + E PE+
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKKIPQ-QLESKEVSESMELCAAVEVMEQGVPEK 483
Score = 31.2 bits (69), Expect = 0.74
Identities = 28/130 (21%), Positives = 60/130 (46%), Gaps = 12/130 (9%)
Query: 33 ELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATS 92
E+E A + + K ++K+EK+K+ D+ + KE LEE + +G KA R +
Sbjct: 25 EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE----LEELSLEAQGIKADRETVA 80
Query: 93 SKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIA 152
K T E+ +D + +K + + ++N + + ++ S +T + +
Sbjct: 81 VKPTENNEEEFTSKDKK--------KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVE 132
Query: 153 VLSVAEEAAD 162
+ S +++ D
Sbjct: 133 MYSGSDDDDD 142
Score = 29.6 bits (65), Expect = 2.2
Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 14/86 (16%)
Query: 27 DAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGG 84
D K KE+ + Y DDD+ KE+R D+ +R+ E +RL ++ +
Sbjct: 580 DKKPSKEMSSDSEYDSDDDR----------TKEERAYDKAKRRIEKRRLEHSKNVNTEKL 629
Query: 85 KAPRVATSSKVT--RAQIEDTLRRDH 108
+AP + V + +I D LR H
Sbjct: 630 RAPIICVLGHVDTGKTKILDKLRHTH 655
Score = 28.5 bits (62), Expect = 4.8
Identities = 21/99 (21%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 23 KAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLK 82
K + K+ E E+ +++++ +E +EE+E+ + E +E +++ +E+DS
Sbjct: 522 KVHIEVKENPEEEE---EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKT 578
Query: 83 GGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAK 121
K P SS +D + + +A EK +
Sbjct: 579 LDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRR 617
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 56.6 bits (135), Expect = 2e-08
Identities = 52/202 (25%), Positives = 101/202 (50%), Gaps = 13/202 (6%)
Query: 10 TKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKE-QRKEEKEKRRLDQLERKK 68
T + A AE + A +K++E ++ K++ + R+E +RK E+E+ RL++ RK+
Sbjct: 395 TDAGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQ 454
Query: 69 ETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPL 128
E +R +EE+ K + G+ R A +A+ E+ L ++ Q +E EKA +
Sbjct: 455 EEERKRQEEEKKKQEGEEKRKAGEEAKRKAE-EELLLKEKQEQE---KQEKAMIEKQKEA 510
Query: 129 EENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQL-PRLKQE 187
E R V E+ +E I +L + +E +R ++R+ ++ + P++K+E
Sbjct: 511 AETKAREVAEQMRLEREQI-----MLQIEQERLER--KKRIDEIMKRTRKSDVPPQVKKE 563
Query: 188 NPNMRLSQLKQLLKKEWLRSPD 209
+P + + + KK L P+
Sbjct: 564 DPKVGVQPAVCVEKKTKLVVPN 585
Score = 37.4 bits (85), Expect = 0.010
Identities = 51/201 (25%), Positives = 86/201 (42%), Gaps = 17/201 (8%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLE 65
QGE + A K AA A + E A K E K EKRR +L+
Sbjct: 355 QGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQ 414
Query: 66 RKKETQ-RLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHL 124
+++E Q R+ +EE +L+ + R A R ++E+ R+ + R+ + +K +
Sbjct: 415 KEQEEQERVEKEEQDRLEREELKRKAEEE---RLRLEEEARKQEEERKRQEEEKKKQ--- 468
Query: 125 EVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHP--ERRMRAAFT-AFEEAQL 181
E R+ EE R E+ + + E+ E++ AA T A E A+
Sbjct: 469 ----EGEEKRKAGEEAK---RKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQ 521
Query: 182 PRLKQENPNMRLSQLKQLLKK 202
RL++E +++ Q + KK
Sbjct: 522 MRLEREQIMLQIEQERLERKK 542
Score = 33.5 bits (75), Expect = 0.15
Identities = 32/134 (23%), Positives = 61/134 (45%), Gaps = 12/134 (8%)
Query: 3 KKFQGENTKSAAARA-RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRL 61
KK +GE + A A R+AE + K+++E + +K ++ K++ E + R +
Sbjct: 466 KKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQ-------EKAMIEKQKEAAETKAREV 518
Query: 62 DQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQ--IEDTLRRDHQLREAPDTAEK 119
+ R + Q +L+ E +L+ K R+ K TR + D ++ P +
Sbjct: 519 AEQMRLEREQIMLQIEQERLERKK--RIDEIMKRTRKSDVPPQVKKEDPKVGVQPAVCVE 576
Query: 120 AKSHLEVPLEENVN 133
K+ L VP + +N
Sbjct: 577 KKTKLVVPNKMEIN 590
Score = 31.6 bits (70), Expect = 0.57
Identities = 26/132 (19%), Positives = 61/132 (46%), Gaps = 18/132 (13%)
Query: 4 KFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQ 63
+ + E K R R+ E K + +++++ + + ++ ++ KE++++EK+++ +
Sbjct: 446 RLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAM-- 503
Query: 64 LERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQI-----EDTLRRDHQLREAPDTAE 118
+E++KE KA VA ++ R QI ++ L R ++ E
Sbjct: 504 IEKQKEAAET-----------KAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTR 552
Query: 119 KAKSHLEVPLEE 130
K+ +V E+
Sbjct: 553 KSDVPPQVKKED 564
Score = 29.6 bits (65), Expect = 2.2
Identities = 24/79 (30%), Positives = 43/79 (54%), Gaps = 11/79 (13%)
Query: 1 MPKKFQGENTKSAAARARR-AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKR 59
+ K+ + E K AAR ++ E + A + +K++E+ + K +EQR+ E +KR
Sbjct: 57 LAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRK-------LEEQRQREDQKR 109
Query: 60 RLDQLERKKETQRLLEEED 78
+ +RK Q+L EEE+
Sbjct: 110 AAVEEKRK---QKLREEEE 125
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 50.8 bits (120), Expect = 9e-07
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 11 KSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
K+ R +AK A AKK +E+E ++++ +R Q +EE+E+R + L++KKE
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ-QEEEERRHQELLQKKKE- 669
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
EE++ K +A R+A + R + E RR+ + RE + E+ + E L E
Sbjct: 670 ----EEQERLRKAAEAKRLAEQREQERREQE---RREQERRE-QERREQERREQERQLAE 721
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRH------PERRMRAAFTAFEEAQLPRL 184
RR E E R +++ L + +E R E + R A +E Q +
Sbjct: 722 QERRREQERLQAE-RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
Query: 185 KQ 186
K+
Sbjct: 781 KE 782
Score = 38.5 bits (88), Expect = 0.005
Identities = 44/189 (23%), Positives = 93/189 (49%), Gaps = 25/189 (13%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQ--LERKKETQRLLE- 75
R + K + K+++ LE+ K++ + + R Q+ EE ++RRL++ L+R++ +++L+
Sbjct: 527 RMDPKCSFVEKERQRLENLRRKEEAEQLRR--QKVEEDKRRRLEEVKLKREERLRKVLQA 584
Query: 76 -EEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNR 134
E ++K K ++ AQI++ + + R A + A+K + + +EE R
Sbjct: 585 RERVEQMKEEKKKQIEQKF----AQIDEKTEKAKEERLAEEKAKKKAAAKK--MEEVEAR 638
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLS 194
R EE + R ++ EE RH E + +E + RL++ RL+
Sbjct: 639 RKQEEEARRLRWLQQ--------EEEERRHQELLQKK-----KEEEQERLRKAAEAKRLA 685
Query: 195 QLKQLLKKE 203
+ ++ ++E
Sbjct: 686 EQREQERRE 694
Score = 34.3 bits (77), Expect = 0.088
Identities = 20/99 (20%), Positives = 51/99 (51%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
++ Q + + RR + + A+ ++++E E + + + + + ++E+ +R L+
Sbjct: 697 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 756
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIE 101
+ ++K+E QRL E + + + KA A +SK ++
Sbjct: 757 EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVD 795
Score = 32.0 bits (71), Expect = 0.44
Identities = 26/123 (21%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
KK + + AA A+R + + ++Q+ E + + + R+EQ ++ E+ R
Sbjct: 667 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 726
Query: 63 QLERKKETQRLLEEEDS-KLKGGKAPRVATSSKVTRAQ--IEDTLRRDHQLREAPDTAEK 119
+ ER + + L E E + +L+ + R K Q + + ++ Q ++A + A
Sbjct: 727 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGA 786
Query: 120 AKS 122
+K+
Sbjct: 787 SKA 789
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 50.8 bits (120), Expect = 9e-07
Identities = 50/182 (27%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 11 KSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
K+ R +AK A AKK +E+E ++++ +R Q +EE+E+R + L++KKE
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ-QEEEERRHQELLQKKKE- 665
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
EE++ K +A R+A + R + E RR+ + RE + E+ + E L E
Sbjct: 666 ----EEQERLRKAAEAKRLAEQREQERREQE---RREQERRE-QERREQERREQERQLAE 717
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRH------PERRMRAAFTAFEEAQLPRL 184
RR E E R +++ L + +E R E + R A +E Q +
Sbjct: 718 QERRREQERLQAE-RELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776
Query: 185 KQ 186
K+
Sbjct: 777 KE 778
Score = 37.7 bits (86), Expect = 0.008
Identities = 35/160 (21%), Positives = 72/160 (45%), Gaps = 10/160 (6%)
Query: 54 EEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLR-E 112
+EKE++RL+ L RK+E ++L ++ + K + V + ++ R Q++ E
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 590
Query: 113 APDTAEKAKSHLEVPLEENVNRRVLEEGS---VEARTIEDAIAVLSVAEEA------ADR 163
E+ + ++ E+ R+ EE + A+ +E+ A EEA
Sbjct: 591 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 164 HPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKE 203
ERR + +E + RL++ RL++ ++ ++E
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 690
Score = 34.3 bits (77), Expect = 0.088
Identities = 20/99 (20%), Positives = 51/99 (51%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
++ Q + + RR + + A+ ++++E E + + + + + ++E+ +R L+
Sbjct: 693 RREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE 752
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIE 101
+ ++K+E QRL E + + + KA A +SK ++
Sbjct: 753 EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVD 791
Score = 32.0 bits (71), Expect = 0.44
Identities = 26/123 (21%), Positives = 57/123 (46%), Gaps = 3/123 (2%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
KK + + AA A+R + + ++Q+ E + + + R+EQ ++ E+ R
Sbjct: 663 KKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRR 722
Query: 63 QLERKKETQRLLEEEDS-KLKGGKAPRVATSSKVTRAQ--IEDTLRRDHQLREAPDTAEK 119
+ ER + + L E E + +L+ + R K Q + + ++ Q ++A + A
Sbjct: 723 EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGA 782
Query: 120 AKS 122
+K+
Sbjct: 783 SKA 785
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 49.3 bits (116), Expect = 3e-06
Identities = 41/191 (21%), Positives = 87/191 (45%), Gaps = 21/191 (10%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLE 65
Q E + + R E K +K++E E+ WK ++K + +E++ +E+E++ +Q E
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEK-IREQEEKIQEQEEKIREQEE 633
Query: 66 RKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAP----DTAEKAK 121
+ +E + + +E++ K+ G + ++ + + Q E R++ ++RE + EK +
Sbjct: 634 KIREQEEMTQEQEEKM-GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 122 SHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQL 181
E+ E+ EE E +E + E +MR E ++
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCE--------------QEEKMQEQEEKMRRQEEKMWEQEV 738
Query: 182 PRLKQENPNMR 192
RL+Q+ M+
Sbjct: 739 -RLRQQEEKMQ 748
Score = 42.4 bits (98), Expect = 3e-04
Identities = 35/194 (18%), Positives = 89/194 (45%), Gaps = 11/194 (5%)
Query: 27 DAKKQKELEDAYWKDDDK------HVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
+ +K++E ED W+ ++K V R+E++ E+E++R +Q E+ + + + E++ K
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 81 LKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEG 140
++ + ++ + R Q E T ++ ++ E + + + ++ +E R E+
Sbjct: 621 IQ-EQEEKIREQEEKIREQEEMTQEQEEKMGEQEE--KMCEQEEKMQEQEETMWRQEEKI 677
Query: 141 SVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLL 200
+ + I + + EE E+ E+ + +++++ MR + K
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--KMQEQEEKMRRQEEKMWE 735
Query: 201 KKEWLRSPDNPMNQ 214
++ LR + M +
Sbjct: 736 QEVRLRQQEEKMQE 749
Score = 36.6 bits (83), Expect = 0.018
Identities = 45/221 (20%), Positives = 90/221 (40%), Gaps = 28/221 (12%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQ----RKEEKEKRRL 61
Q E + + RR E +K + E+ W+ ++K MR+++ KEEK +R+
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK--MRRQEEMMWEKEEKMRRQE 383
Query: 62 DQLERKKETQRLLEE---EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAE 118
+ + K+E R LEE E K++ + R Q E+ +R + +E +
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKR----------QEEEKIREQEKRQE-----Q 428
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
+AK + ++ E+ R E + EE + E R E+
Sbjct: 429 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ 488
Query: 179 AQLPRLK----QENPNMRLSQLKQLLKKEWLRSPDNPMNQR 215
++ R K ++ +R + K ++E +R + + ++
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529
Score = 36.6 bits (83), Expect = 0.018
Identities = 41/216 (18%), Positives = 93/216 (43%), Gaps = 21/216 (9%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLE 65
Q E + + R E K +K +E E+ W+ ++K +EQ + +E+ ++ + E
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK---IREQEEMWREEEKMHEQE 557
Query: 66 RKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHL- 124
+ E ++ E+ED ++ + R Q E R++ ++RE + ++ + +
Sbjct: 558 KIWEEEKRQEQED---------KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 125 --EVPLEENVNRRVLEEGSVEARTIEDAI---AVLSVAEEAADRHPERRMRAAFTAFEEA 179
E + E + ++E + R E+ I ++ +E E +M +E
Sbjct: 609 KQEEKIREQEEK--IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666
Query: 180 QLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQR 215
+ +QE +R + K ++E +R + M ++
Sbjct: 667 EETMWRQEE-KIREQEKKIREQEEKIREQEEMMQEQ 701
Score = 34.7 bits (78), Expect = 0.067
Identities = 33/203 (16%), Positives = 87/203 (42%), Gaps = 21/203 (10%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDK------HVMRKEQRKEEKEKRR 60
G+ +S +A+ + + + ++ E+ W+ ++K + +E++ E+E++
Sbjct: 271 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 61 LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
+Q E+ + + ++ E++ K++ + + E+ +RR ++ + EK
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMR---------RQEEMMWEKEEKMRRQEEMMW--EKEEKM 379
Query: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
+ E+ E+ R LEE E I + E+ ++ + A EE
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-- 437
Query: 181 LPRLKQENPNMRLSQLKQLLKKE 203
+++++ +R + K ++E
Sbjct: 438 --KIREQEEKIREQEKKMWRQEE 458
Score = 32.0 bits (71), Expect = 0.44
Identities = 26/138 (18%), Positives = 65/138 (47%), Gaps = 12/138 (8%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
+K + + K + E + + +K++E E+ W+ ++K + +E+ +KEK
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE-MWRQEEK-IHEQEEIWRQKEKMHEQ 501
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDT-AEKAK 121
+ + +K+ +++ +E+ ++ + R Q E R++ ++RE + E+ K
Sbjct: 502 EEKIRKQEEKVWRQEE---------KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 122 SHLEVPLEENVNRRVLEE 139
H + + E R+ E+
Sbjct: 553 MHEQEKIWEEEKRQEQED 570
Score = 32.0 bits (71), Expect = 0.44
Identities = 29/122 (23%), Positives = 60/122 (49%), Gaps = 10/122 (8%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEED 78
R + K +K ++ E+ W+ ++K + +E++ E+E++ Q E+ +E + + EE+
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEK-IREQEEKIREQEEKMWRQEEKIREQEEMWREEE 551
Query: 79 SKLKGGKAPRVATSSKVTRAQIEDTL-RRDHQLREAPDTAEKAKSHLEVPLEENVNRRVL 137
K + ++ K R + ED + R++ ++RE EK E E+ R+
Sbjct: 552 ---KMHEQEKIWEEEK--RQEQEDKMWRQEEKIRE---QEEKVWRQEEKIREQEEKRQEQ 603
Query: 138 EE 139
EE
Sbjct: 604 EE 605
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2147 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2203
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2204 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2252
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2305 RALAEKMLKEK 2315
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1435
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1436 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1548
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1549 ERRLRQ 1554
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 1996 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1470 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1527
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1575
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1628
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2318 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2377 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2426
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2427 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2470 QLKSE--EMQTVQQEQLLQE 2487
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1774 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1832 ERVLAEKLAAIGEA--TRLKTE 1851
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2605 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2656
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2657 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2689
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2151 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2207
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2208 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2256
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2257 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2309 RALAEKMLKEK 2319
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1439
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1440 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1499
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1500 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1552
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1553 ERRLRQ 1558
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 2000 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2056 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1474 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1531
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1579
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1632
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2322 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2381 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2430
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2431 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2474 QLKSE--EMQTVQQEQLLQE 2491
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1778 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1836 ERVLAEKLAAIGEA--TRLKTE 1855
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2444
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2445 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2564
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2550 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2609 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2660
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2661 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2693
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2147 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2203
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2204 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2252
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2253 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2305 RALAEKMLKEK 2315
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1435
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1436 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1548
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1549 ERRLRQ 1554
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 1996 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2052 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1470 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1527
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1575
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1628
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2318 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2377 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2426
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2427 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2470 QLKSE--EMQTVQQEQLLQE 2487
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1774 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1832 ERVLAEKLAAIGEA--TRLKTE 1851
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2560
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2546 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2605 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2656
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2657 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2689
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2115 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2171
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2172 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2220
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2221 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2273 RALAEKMLKEK 2283
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1403
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1404 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1463
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1464 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1516
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1517 ERRLRQ 1522
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 1964 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2020 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1438 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1495
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1543
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1596
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2286 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2345 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2394
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2395 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2438 QLKSE--EMQTVQQEQLLQE 2455
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1742 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1800 ERVLAEKLAAIGEA--TRLKTE 1819
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2408
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2409 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2528
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2514 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2573 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2624
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2625 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2657
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2284 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2340
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2341 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2389
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2390 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2442 RALAEKMLKEK 2452
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1572
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1573 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1633 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1685
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1686 ERRLRQ 1691
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 2133 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1607 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1664
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1712
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1765
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2455 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2514 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2563
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2564 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2607 QLKSE--EMQTVQQEQLLQE 2624
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1911 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1969 ERVLAEKLAAIGEA--TRLKTE 1988
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2577
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2578 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2697
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2683 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2742 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2793
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2794 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2826
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2125 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2181
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2182 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2230
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2283 RALAEKMLKEK 2293
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1413
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1414 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1474 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1526
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1527 ERRLRQ 1532
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 1974 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1448 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1505
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1553
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1606
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2296 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2355 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2404
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2405 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2448 QLKSE--EMQTVQQEQLLQE 2465
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1752 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1810 ERVLAEKLAAIGEA--TRLKTE 1829
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2418
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2419 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2538
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2524 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2583 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2634
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2635 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2667
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2133 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2189
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2190 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2238
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2239 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2291 RALAEKMLKEK 2301
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1421
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1422 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1481
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1482 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1534
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1535 ERRLRQ 1540
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 1982 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2038 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1456 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1513
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1561
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1614
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2304 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2363 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2412
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2413 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2456 QLKSE--EMQTVQQEQLLQE 2473
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1760 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1818 ERVLAEKLAAIGEA--TRLKTE 1837
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2426
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2427 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2546
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2532 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2591 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2642
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2643 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2675
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 48.5 bits (114), Expect = 4e-06
Identities = 55/191 (28%), Positives = 96/191 (50%), Gaps = 26/191 (13%)
Query: 17 ARRAEAKAAADAKKQKELEDA----YWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR 72
ARRA+A+ AA +QK+ DA + K ++ + +K Q ++E RL QLE +
Sbjct: 2174 ARRAQAEQAA--LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-QLEETDHQKN 2230
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
LL+EE +LK AT + R+Q+E+ L +R + K K+ +E EN
Sbjct: 2231 LLDEELQRLKA-----EATEAARQRSQVEEEL---FSVRVQMEELSKLKARIEA---ENR 2279
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ ++ + + E+A + VAEEAA R + A E A+L +L +E+ +
Sbjct: 2280 ALILRDKDNTQRFLQEEAEKMKQVAEEAA--------RLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 193 LSQLKQLLKKE 203
+ +++LK++
Sbjct: 2332 RALAEKMLKEK 2342
Score = 45.8 bits (107), Expect = 3e-05
Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 17/186 (9%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRR-----LDQLERKKETQRLL 74
AEA A A A+ ++E ++ + ++ V R+E + ++++R L QL + E +
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1462
Query: 75 EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----DHQLREAPDTAEKAKSHLEVPLEE 130
+ ++ R+ +V R Q+E T R+ + +L+ AE+A++ EE
Sbjct: 1463 KARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
Query: 131 NVN-RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENP 189
RR +++ S R E +A AE A R +R A A EE RL+ E
Sbjct: 1523 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR----ALQALEEL---RLQAEEA 1575
Query: 190 NMRLSQ 195
RL Q
Sbjct: 1576 ERRLRQ 1581
Score = 40.8 bits (94), Expect = 0.001
Identities = 47/208 (22%), Positives = 87/208 (41%), Gaps = 16/208 (7%)
Query: 11 KSAAARAR--------RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+AA +A R+ A+ +K+Q ELE A + R+ + EE+ ++ L
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD----TAE 118
E ++ EE +LK +V + ++ +++ R+ +EA E
Sbjct: 2023 AEEEAARQRKAALEEVERLKA----KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEE 178
KA + E+ + + + +E SV + +A A AEEA + + AA + +
Sbjct: 2079 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Query: 179 AQLPRLKQENPNMRLSQLKQLLKKEWLR 206
+ RLKQ ++ + E LR
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Score = 38.1 bits (87), Expect = 0.006
Identities = 48/175 (27%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER 66
G + A RAR EA+A + Q+E E + D+ RK Q + E R + E
Sbjct: 1497 GAEGELQALRARAEEAEAQK-RQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1554
Query: 67 KKETQRLLEE-EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLE 125
+E QR L+ E+ +L+ +A R ++V RA+ Q++ A +TA+++ E
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAEVERAR---------QVQVALETAQRS---AE 1602
Query: 126 VPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
L+ + +E E+ +AV + EEA R ++ A A EEA+
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAE 1655
Score = 37.4 bits (85), Expect = 0.010
Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 40/200 (20%)
Query: 13 AAARARRAEAKAAADAKKQKEL--EDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
A A R +A+A ++QKEL E A +DK M ++ +E + +R + ER+++
Sbjct: 2345 AVQEATRLKAEAEL-LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
+ E E KL RVA S+ ED R Q E + + E+ +E
Sbjct: 2404 EMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT----ELATQE 2453
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE--------EAQLP 182
V + L + + +D H R+R A E EA+L
Sbjct: 2454 KVT----------------LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 183 RLKQENPNMRLSQLKQLLKK 202
+LK E M+ Q +QLL++
Sbjct: 2497 QLKSE--EMQTVQQEQLLQE 2514
Score = 35.0 bits (79), Expect = 0.051
Identities = 51/202 (25%), Positives = 90/202 (44%), Gaps = 36/202 (17%)
Query: 18 RRAEAKAAADAKKQKELEDA--YWKDDDKHVMRKEQRKEEKEKRR--------------- 60
+++ A+A A+ +K++ +A K +++ V ++E ++E EK+R
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 61 -----LDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKV------TRAQIEDTL-RRDH 108
+ E+ ++ ++LLEEE ++L+ A ++ RA++E L +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 109 QLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADR---HP 165
E+ T+EK+K LE E R + EE + E+A +AEE A R
Sbjct: 1801 AEEESRSTSEKSKQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 166 ERRMRAAFTAFEEAQLPRLKQE 187
ER + A EA RLK E
Sbjct: 1859 ERVLAEKLAAIGEA--TRLKTE 1878
Score = 32.7 bits (73), Expect = 0.26
Identities = 51/224 (22%), Positives = 92/224 (41%), Gaps = 26/224 (11%)
Query: 6 QGENTKSAAARARRAEAKAAADAKK-QKELEDAYWKDDDKHVMRKE-----QRKEEKEKR 59
+ E K A RA+A+A DA++ +K+ E+ K + +E Q E + ++
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2467
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA------ 113
ER +E LE E KL+ S ++ Q E L+ L+++
Sbjct: 2468 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2527
Query: 114 -----PDTAEKAKSHLEVPLEENVNR--RVLEEGSVEARTIEDAIAVLSVAEEAADR--- 163
E+ K+ LE ++ V + ++ EE + + +E L + E A R
Sbjct: 2528 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQH 2587
Query: 164 HPERRMRAAFTAFEEAQLPRLKQE----NPNMRLSQLKQLLKKE 203
E +R ++ + R +QE N RL + QLL+++
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Score = 32.0 bits (71), Expect = 0.44
Identities = 35/153 (22%), Positives = 68/153 (44%), Gaps = 12/153 (7%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEE 77
+R A ++Q E E+ + ++ + + EQ++ ++E+ ++ +R +E +LLEE+
Sbjct: 2573 QRLVASMEEARRRQHEAEEGVRRKQEE-LQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Query: 78 DSKLKGGKAPRVATSSKVTRAQI--EDTLRRDHQLREAPDTAEKAKSHLEVPLEENVN-R 134
+A S +VT +Q+ TL + P AE H L V+ +
Sbjct: 2632 -------HRAALAHSEEVTASQVAATKTLPNGRDALDGP-AAEAEPEHSFDGLRRKVSAQ 2683
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
R+ E G + A ++ + +E A R R
Sbjct: 2684 RLQEAGILSAEELQRLAQGHTTVDELARREDVR 2716
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 47.8 bits (112), Expect = 8e-06
Identities = 34/104 (32%), Positives = 49/104 (47%), Gaps = 7/104 (6%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKD-DDKHVMRKEQRKEEKEKRRLDQLE- 65
E K A RA+ K + K+ KE E ++ D+K K++ KEE+ K R + LE
Sbjct: 358 EKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEA 417
Query: 66 -----RKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTL 104
RKKE ++ L EE+ ++K KA K Q TL
Sbjct: 418 KLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTL 461
Score = 38.1 bits (87), Expect = 0.006
Identities = 52/231 (22%), Positives = 92/231 (39%), Gaps = 30/231 (12%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
KKF +T+ R +R + + K + E E+ +K ++ KEE +K++ +
Sbjct: 323 KKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEK-----EKLKEEAKRAKEEAKKKKEE 377
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKS 122
+ E K++ +R E+D K K + ++++ R++ Q EK K
Sbjct: 378 EKELKEKERREKREKDEK------------EKAEKQRLKEERRKERQEALEAKLEEKRKK 425
Query: 123 HLEVPLEENVNRRVLEEGSV-----------EARTIEDAIAVLSVAEEAADRHPERRMRA 171
E L E R E+ + +T+ + + E R R
Sbjct: 426 EEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRT 485
Query: 172 AFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRS-PDNPMNQRAVPFNA 221
AF +QL +L Q+ S LK L ++ LRS P + + A FN+
Sbjct: 486 AFHPDLCSQLDQLLQQQSG-EFSFLKDLKGRQPLRSGPTHVSTRNADIFNS 535
Score = 29.6 bits (65), Expect = 2.2
Identities = 41/179 (22%), Positives = 73/179 (40%), Gaps = 13/179 (7%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
KK + + K R +R + + K++ + E + + +E+RK+E+EKR +
Sbjct: 374 KKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLRE 433
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSS--KVTRAQIEDTLRRDHQLREA--PDTAE 118
+ +R K + + K K +AP+ S K +I++ + + R A PD
Sbjct: 434 EEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCS 493
Query: 119 KAKSHLEVP------LEENVNRRVLEEGSVEARTIEDAI---AVLSVAEEAADRHPERR 168
+ L+ L++ R+ L G T I V+ V D PERR
Sbjct: 494 QLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERR 552
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 47.4 bits (111), Expect = 1e-05
Identities = 41/192 (21%), Positives = 90/192 (46%), Gaps = 25/192 (13%)
Query: 29 KKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPR 88
KK +E E W ++K MR+E+R E+EK+ ++ E +E + ++E++ K++ +
Sbjct: 569 KKTQEQEKKTWDQEEK--MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
Query: 89 VATSSKVTRAQIEDTLRRDHQLRE----------APDTAEKAKSHLEVPLEENV---NRR 135
K+ + Q E ++ ++ E P+ EK H ++ +E + +
Sbjct: 627 WEQEEKM-QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 136 VLEEGSVEARTIEDAIAVL---SVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMR 192
+ E+ +E +T E + EE + R E++MR EE ++ R ++E +
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR------EEEEMMREQEEKMQEQ 739
Query: 193 LSQLKQLLKKEW 204
++++ ++ W
Sbjct: 740 EEKMQEQEEEMW 751
Score = 40.8 bits (94), Expect = 0.001
Identities = 43/202 (21%), Positives = 88/202 (43%), Gaps = 28/202 (13%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K ++ E + R + K + K+ +E E+ + ++K ++E+ +E++EK
Sbjct: 315 KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK-MWR 373
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKS 122
Q ER E ++ + E++ K+ R Q E +D +LRE + + +
Sbjct: 374 QEERLWEQEKQMREQEQKM---------------RDQEERMWEQDERLREKEERMREQEK 418
Query: 123 HLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLP 182
E +E+ + ++E + R E+ + EE R E++MR EE +
Sbjct: 419 MWE-QVEKMREEKKMQEQEKKTRDQEE-----KMQEEERIREREKKMR------EEEETM 466
Query: 183 RLKQENPNMRLSQLKQLLKKEW 204
R ++E + + + +KEW
Sbjct: 467 REQEEKMQKQEENMWEQEEKEW 488
Score = 37.4 bits (85), Expect = 0.010
Identities = 40/199 (20%), Positives = 90/199 (45%), Gaps = 16/199 (8%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEED 78
R E + KK ++ E+ W+ +++ + +E + E+E++ Q +R +E ++ L E++
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEER-LREQEGKMREQEEKMWRQEKRLREQEKELREQE 334
Query: 79 SKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
+L+ K R + + Q E ++ ++RE + + + L E+ R E
Sbjct: 335 KELREQKELR--EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL---WEQEKQMREQE 389
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLK---QENPNMRLSQ 195
+ + R E+ + ++ R E RMR +E+ + R + QE Q
Sbjct: 390 Q---KMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Query: 196 LKQLLKKEWLRSPDNPMNQ 214
+++ ++E +R + M +
Sbjct: 443 EEKMQEEERIREREKKMRE 461
Score = 37.0 bits (84), Expect = 0.014
Identities = 40/205 (19%), Positives = 90/205 (43%), Gaps = 22/205 (10%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDK------HVMRKEQRKEEKEKRRLDQLERKKETQR 72
R + + ++ +E E+ W+ ++K + R+E+R E+EK+ +Q ++ ++ +
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 73 LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
+ E+D +L+ K R+ K+ Q+E +R + +++E EK E ++E
Sbjct: 398 RMWEQDERLR-EKEERMREQEKMWE-QVE-KMREEKKMQE----QEKKTRDQEEKMQEEE 450
Query: 133 NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQ---ENP 189
R E + + + + EE + E +++ +LP K+ E
Sbjct: 451 RIRERE------KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Query: 190 NMRLSQLKQLLKKEWLRSPDNPMNQ 214
M+ + K ++E +R + Q
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQ 529
Score = 36.2 bits (82), Expect = 0.023
Identities = 22/117 (18%), Positives = 54/117 (46%), Gaps = 5/117 (4%)
Query: 16 RARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLE 75
+ + E K K +K+ ++ K D+ MR+E+ E+EK+ ++ E +E + ++
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ 737
Query: 76 EEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV 132
E++ K++ + K+ + + + + P+ EK H ++ +E +
Sbjct: 738 EQEEKMQEQEEEMWEQEEKMWEQE-----EKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Score = 34.7 bits (78), Expect = 0.067
Identities = 38/211 (18%), Positives = 90/211 (42%), Gaps = 22/211 (10%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
KK Q + K+ + E + + +K+ E+ ++ ++ + ++E+ E+E++
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 63 QLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQ-----IEDTLRRDHQLREAPDTA 117
Q ++ ++L E+E + + ++ + R Q E + R ++RE D
Sbjct: 490 QQRLPEQKEKLWEQEKMQ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 118 EKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVL----SVAEEAADRHPERRMRAAF 173
+ E + + + +E +E +T E + EE R E++MR
Sbjct: 547 WEQ----EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR--- 599
Query: 174 TAFEEAQLPRLKQENPNMRLSQLKQLLKKEW 204
EE ++ R ++E + ++++ +K W
Sbjct: 600 ---EEEEMMREQEEKMQEQEEKMQEQEEKMW 627
Score = 33.5 bits (75), Expect = 0.15
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 6/84 (7%)
Query: 1 MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKE------ 54
M KK Q + K+ R E KK +E E+ + ++K ++E+ +E
Sbjct: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMW 751
Query: 55 EKEKRRLDQLERKKETQRLLEEED 78
E+E++ +Q E+ E QRL E+++
Sbjct: 752 EQEEKMWEQEEKMWEQQRLPEQKE 775
Score = 32.3 bits (72), Expect = 0.33
Identities = 16/65 (24%), Positives = 37/65 (56%), Gaps = 4/65 (6%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEK----EKRRLDQLERKKETQRL 73
R E K +K +E E+ W+ ++K ++E+ E++ +K +L + E+ +E +++
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKI 789
Query: 74 LEEED 78
E+E+
Sbjct: 790 WEQEE 794
Score = 31.2 bits (69), Expect = 0.74
Identities = 37/171 (21%), Positives = 73/171 (42%), Gaps = 22/171 (12%)
Query: 45 HVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTL 104
+ +++E ++E+E R ++ RK+E + +EE + + GK R Q E
Sbjct: 268 NTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGK----------MREQEEKMW 317
Query: 105 RRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRH 164
R++ +LRE EK E L E R EE +++ + EE
Sbjct: 318 RQEKRLRE----QEKELREQEKELREQKELREQEE------QMQEQEEKMWEQEEKMREQ 367
Query: 165 PERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQR 215
E+ R +E+ + +++++ MR + + + E LR + M ++
Sbjct: 368 EEKMWRQEERLWEQEK--QMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 47.0 bits (110), Expect = 1e-05
Identities = 41/182 (22%), Positives = 87/182 (47%), Gaps = 8/182 (4%)
Query: 27 DAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKA 86
+ ++++E E Y K D+ ++ +EE+EKRRL + ER+ + L++E+ +L G +
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 87 PRVATSSKVTRAQIEDTLRRDHQ--LREAPDTAEKAKSHLEVPLEENVNR---RVLEEGS 141
+ + E+ L+++ + LRE P+ + + + EE + + ++L E
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 142 VEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLK 201
+ R E + EE + E+ +R +L R +E ++ + +QLL+
Sbjct: 1129 EKRRRQE--LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE-EQLLR 1185
Query: 202 KE 203
+E
Sbjct: 1186 EE 1187
Score = 46.2 bits (108), Expect = 2e-05
Identities = 54/220 (24%), Positives = 96/220 (43%), Gaps = 30/220 (13%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQK---ELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQL 64
E T+ R+ + K + ++++ +LE+ ++ + R++Q + E+E+RR +L
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER--REQQLRREQEERREQRL 519
Query: 65 ERKKETQRLL--------------EEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQL 110
+R++E +RL E + LK + R+ + R + E RRD L
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 111 -REAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEE------AADR 163
RE ++ K E LE+ + R +E E R E + EE ++
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERR-EQRLKREEPEEERRQQLLKSEE 638
Query: 164 HPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKE 203
ERR + +E + RLK+E R L+Q LK+E
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEER---LEQRLKRE 675
Score = 45.8 bits (107), Expect = 3e-05
Identities = 43/205 (20%), Positives = 88/205 (42%), Gaps = 19/205 (9%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQ-RKEEKEKRRLDQL 64
Q E + R ++ E + ++Q+E + + + + R++Q R+E++E+RR QL
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 65 ERKKETQR--LLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKS 122
R+++ +R L E + + R + + + E LRR+ QLR + +
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 123 HLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLP 182
H + E+ + R E R EE +RH + R + +E +
Sbjct: 438 HEQERREQRLKREQEERRDWLKR------------EEETERHEQERRKQQLKRDQEEERR 485
Query: 183 ----RLKQENPNMRLSQLKQLLKKE 203
+L++E + + +Q L++E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRRE 510
Score = 45.4 bits (106), Expect = 4e-05
Identities = 39/183 (21%), Positives = 85/183 (46%), Gaps = 15/183 (8%)
Query: 32 KELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKL----KGGKAP 87
+E E+ W+ + + ++E++ +E+E +R +L+ ++E R LE ++ + + +
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 88 RVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPL----EENVNRRVLEEGSVE 143
R+ ++ R Q E+ + + RE + E+ + E L EE +++ E E
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 144 ARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKE 203
R + + E + E+++R E QL R +Q +L + +QL +++
Sbjct: 359 RREQQ-------LRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 204 WLR 206
LR
Sbjct: 412 QLR 414
Score = 43.1 bits (100), Expect = 2e-04
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 15/206 (7%)
Query: 4 KFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKD-----DDKHVMRKEQRKE-EKE 57
K+Q E K A R + K + ++ ++LED+ +D D +H++ ++Q ++ E+E
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGREN-EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE 1282
Query: 58 KRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTA 117
+RR Q +R + LE E+ K + + ++ R + E+ RR R+ +
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342
Query: 118 EKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFE 177
+ + E PL R E E R E L EE R ER + +
Sbjct: 1343 QLLQEREEQPLRRQERDRKFRE--EELRHQEQGRKFLE--EEQRLRRQERERK----FLK 1394
Query: 178 EAQLPRLKQENPNMRLSQLKQLLKKE 203
E Q R ++ +R + ++ ++E
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEE 1420
Score = 42.7 bits (99), Expect = 2e-04
Identities = 38/156 (24%), Positives = 78/156 (50%), Gaps = 16/156 (10%)
Query: 18 RRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKR----RLDQLERKKETQRL 73
+R E K ++++ L+ + D+ + R+E+R++++ KR RL+Q +++E +RL
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 74 LEEE--DSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEEN 131
+EE + +LK + P ++ +++ ++ R+ RE + E+ E EE
Sbjct: 611 EQEERREQRLK-REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE--EER 667
Query: 132 VNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPER 167
+ +R+ E E R E +AEE ++ ER
Sbjct: 668 LEQRLKREHEEERREQE-------LAEEEQEQARER 696
Score = 42.0 bits (97), Expect = 4e-04
Identities = 43/182 (23%), Positives = 76/182 (41%), Gaps = 25/182 (13%)
Query: 29 KKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQR----LLEEEDSKLKGG 84
++Q+E + + + + R++Q + E+E+RR QL R++E +R L E++ + +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 85 KAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPL-EENVNRRVLEEGSVE 143
+ R + + + E LRR+ QLR + + E L E RR EE
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE---- 431
Query: 144 ARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQ--LKQLLK 201
E +H + R +E + LK+E R Q KQ LK
Sbjct: 432 --------------ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 202 KE 203
++
Sbjct: 478 RD 479
Score = 40.4 bits (93), Expect = 0.001
Identities = 49/219 (22%), Positives = 89/219 (40%), Gaps = 17/219 (7%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K +G SA R + ++Q+ + ++++K R+++R+ EKE + L+
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 63 ---QLERKKETQRLLEEEDSKLKGGKAPRVATS--SKVTRAQI-EDTLRRDHQLREAPDT 116
QL+R++ Q+L EEED + + R + R Q+ E+ RR H L P
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 117 AEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAF 176
E+ + ++ EE L+ E R ++ +E R E+ +
Sbjct: 896 QEQLRKEQQLLQEE---EEELQREEREKRRRQE--------QERQYREEEQLQQEEEQLL 944
Query: 177 EEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQR 215
E + R +QE K K+E L + +R
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/174 (23%), Positives = 75/174 (43%), Gaps = 16/174 (9%)
Query: 30 KQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRV 89
K+++ E W ++ R EQ + +++ +R DQ E ++E LEEE+ + +
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKR-DQEEERRERWLKLEEEER-----REQQE 501
Query: 90 ATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIED 149
++ R Q E +R + E ++ +S ++ E+ R L + E R ++
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 150 AIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKE 203
E+ R E R EE + RLK+E +L+Q LK+E
Sbjct: 562 R------REQRLKREQEERRDQLLKREEERRQQRLKREQE----ERLEQRLKRE 605
Score = 39.3 bits (90), Expect = 0.003
Identities = 48/211 (22%), Positives = 95/211 (45%), Gaps = 31/211 (14%)
Query: 5 FQGENTKSAAARA---RRAEAKAAADA-KKQKEL--EDAYWKDDDKHVMRKEQRKEEKEK 58
FQ E K R R+ E K + ++Q+EL E+ + ++ +R+E+++EE+++
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 59 RRL---DQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD 115
+RL QL RK+E +R ++E+ + + + + + + + E RR+ QLR +
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQ-QEERREQQLRREQEERREQQLRREQE 356
Query: 116 TAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTA 175
+ E+ + R EE + E + E+++R
Sbjct: 357 EERR---------EQQLRREQEEERREQQLRREQQL------------RREQQLRREQQL 395
Query: 176 FEEAQLPRLKQENPNMRLSQLKQLLKKEWLR 206
E QL R +Q +L + +QL +++ LR
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLR 426
Score = 38.9 bits (89), Expect = 0.004
Identities = 39/185 (21%), Positives = 82/185 (44%), Gaps = 14/185 (7%)
Query: 27 DAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLER--------KKETQRLLEEED 78
+ ++++E E Y ++++ ++ +EE+EKRR + ER ++E ++LL EE
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 79 SKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
K + + R + + + E L + + R + + + E+ EE ++L
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE---EQLLR 1095
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
E + R E EE + E+ +R +L R +E ++ + +Q
Sbjct: 1096 EEPEKRRRQERERQCRE--EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE-EQ 1152
Query: 199 LLKKE 203
LL++E
Sbjct: 1153 LLREE 1157
Score = 38.5 bits (88), Expect = 0.005
Identities = 51/228 (22%), Positives = 99/228 (43%), Gaps = 33/228 (14%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAK--KQKELEDAYWKDDDKHVMRKEQRKEEKEKRR 60
+KF+ E K R + E K D + +++E + ++ D+ EQ +E+E+++
Sbjct: 1579 RKFRLEEQK---VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635
Query: 61 LDQLER-----KKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR---DHQLRE 112
L + ER ++E Q +E + +L+ + + ++ + E LRR D + RE
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE 1695
Query: 113 APDTAEKAKSHLEVPLEEN------VNRRVLEEGSVEARTIEDAIA----VLSVAEEAAD 162
+ + + EE + R+ EE + T ++ + + EE
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 163 RHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDN 210
R PER EE QL R +++ QL+Q +++ LRS ++
Sbjct: 1756 R-PER---------EEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793
Score = 38.1 bits (87), Expect = 0.006
Identities = 44/183 (24%), Positives = 81/183 (44%), Gaps = 23/183 (12%)
Query: 27 DAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKA 86
+ ++++ELE Y ++++ ++ +EE+EKRR +++E Q EEE + K +
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRR-----QERERQYREEEELQRQKRKQR 1213
Query: 87 PRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSH-LEVPLEENVNRRVLEEGSVEAR 145
R ++ R D + + P+ + + + EN R LE+ + R
Sbjct: 1214 YR------------DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Query: 146 TIEDAIAVLSVAEEAADRHPERRMRAAFTAF--EEAQLPRLKQENPNMR---LSQLKQLL 200
+ + L ++ DR ERR EE QL R +Q+ R + KQLL
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Query: 201 KKE 203
++E
Sbjct: 1322 REE 1324
Score = 37.7 bits (86), Expect = 0.008
Identities = 46/201 (22%), Positives = 84/201 (41%), Gaps = 30/201 (14%)
Query: 27 DAKKQKELEDAYWKDDDKHVMRKEQRK--EEKEKRRLDQLERK--------KETQRLLEE 76
+ ++++E E Y KD K + +KE++ EE EKRR + E+K +E ++LL E
Sbjct: 949 EKRRRQERERQYRKD--KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 77 EDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENV---- 132
E K + + R + + E LR + + R + + + E+ EE
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGE 1066
Query: 133 -----NRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPR---- 183
R+ LE + ++ L E R ER + EE +L +
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR----EEEELQQEEEQ 1122
Query: 184 -LKQENPNMRLSQLKQLLKKE 203
L++E R +L++ ++E
Sbjct: 1123 LLREEREKRRRQELERQYREE 1143
Score = 37.4 bits (85), Expect = 0.010
Identities = 46/205 (22%), Positives = 82/205 (40%), Gaps = 12/205 (5%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEK--EKRRLDQLERKKETQRLLEEED 78
E K A K+ L+D ++D + ++++ EE+ ++RR + E+++E E+ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 79 SKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVL- 137
+ + + R ++ R + E R + + E + K E P EE + RR L
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 138 -------EEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPN 190
EE + R +D + +E R R EE Q R QE
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 191 MRLSQLKQLLKKEWLRSPDNPMNQR 215
+Q L++E R + QR
Sbjct: 277 QLRKLERQELRRE--RQEEEQQQQR 299
Score = 37.0 bits (84), Expect = 0.014
Identities = 40/192 (20%), Positives = 88/192 (45%), Gaps = 26/192 (13%)
Query: 29 KKQKELEDAYWKDDDKHVMRKEQR-KEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAP 87
K++++ ++ ++++++ +EQ +EE+EKRR + ER+ + L++++ +L G +
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 88 RVATSSKVTRAQIEDTLRRDHQ--LREAPD------------TAEKAKSHLEVPLEENVN 133
+ + + + E+ L+++ + LRE + ++ + E L E
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 134 RRVLEEGSVEARTIEDAIAVLSVAEE---AADRHPERRMRAAFTAFEEAQL----PRLKQ 186
+R L+E + R E+ L EE +R RR +E +L +L +
Sbjct: 1040 KRRLQERERQYREEEE----LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 187 ENPNMRLSQLKQ 198
E P R Q ++
Sbjct: 1096 EEPEKRRRQERE 1107
Score = 36.6 bits (83), Expect = 0.018
Identities = 49/213 (23%), Positives = 89/213 (41%), Gaps = 19/213 (8%)
Query: 7 GENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRL--DQL 64
G+ + R A+ ++KQ+ LE + D+ + R+ Q +E+E+RR +QL
Sbjct: 134 GQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL 193
Query: 65 ERKK--ETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKS 122
+ K ET+ +EE +L+ + + + + Q RR+ Q R + EK
Sbjct: 194 QSCKGHETEEFPDEE--QLRRRELLELRRKGREEKQQ----QRRERQDRVFQEEEEKEWR 247
Query: 123 HLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLP 182
E L + ++ EE R +++ EE R ER+ EE Q
Sbjct: 248 KRETVLRKE-EEKLQEEEPQRQRELQE--------EEEQLRKLERQELRRERQEEEQQQQ 298
Query: 183 RLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQR 215
RL++E R + ++ ++E R Q+
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Score = 36.2 bits (82), Expect = 0.023
Identities = 42/208 (20%), Positives = 94/208 (45%), Gaps = 15/208 (7%)
Query: 3 KKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLD 62
K+ + E + R +R + + + ++Q+ L K +++ R++Q + E+++RR
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLL-----KSEEQEERRQQQLRREQQERREQ 657
Query: 63 QLERKKETQRLLE--EEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKA 120
+L+R++E +RL + + + + + + + R +I+ + + E+ A ++
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 121 KSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFT----AF 176
K + +E RR +E E R ++ E A + E R FT A
Sbjct: 718 KVYSRPRKQEGQRRRQEQE---EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774
Query: 177 EEAQLPRLK-QENPNMRLSQLKQLLKKE 203
E+++ R + P +R + +QL +E
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEE 802
Score = 33.5 bits (75), Expect = 0.15
Identities = 42/214 (19%), Positives = 89/214 (41%), Gaps = 21/214 (9%)
Query: 2 PKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKE---- 57
P++ Q E + A+ R +++ +++ E ++ D+ +EQ +E+E
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 58 -------KRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQL 110
K R ++L +++ ++ LEEE + + + + R Q R+ QL
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ-----EREQQL 1408
Query: 111 REAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMR 170
R+ D K + + + +R+ EE R + + + +RH R+ R
Sbjct: 1409 RQ--DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH--RKFR 1464
Query: 171 AAFTAFEEAQLPRL-KQENPNMRLSQLKQLLKKE 203
+E + +L +QE L + +QL ++E
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Score = 33.5 bits (75), Expect = 0.15
Identities = 31/167 (18%), Positives = 81/167 (48%), Gaps = 17/167 (10%)
Query: 40 KDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQ 99
+D D+ +EQ ++E+E+++L + ER ++ + LEE+ + + + + ++ R +
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFR--LEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 100 IEDTLR--RDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVA 157
+ LR RD + RE ++ + E+ ++R+ + + +E+ +
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQERE-------EQQLHRQ-----ERDRKFLEEEPQLRRQE 1656
Query: 158 EEAADRHP-ERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKE 203
E RH +R+ R +E + +L+++ + + + +Q L+++
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Score = 33.5 bits (75), Expect = 0.15
Identities = 27/138 (19%), Positives = 65/138 (47%), Gaps = 21/138 (15%)
Query: 29 KKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRL-------------DQLERKKETQRLLE 75
++++E + ++ D+ +EQ ++E+E+++L +QL+ +++ QRL +
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 76 EEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRR 135
E D + + + + AT K +R + ++ + + Q R + + H+ +E R
Sbjct: 1840 ERDRQYRAEE--QFATQEK-SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHR 1896
Query: 136 VL-----EEGSVEARTIE 148
+ +EG R +E
Sbjct: 1897 QVGEIKSQEGKGHGRLLE 1914
Score = 32.7 bits (73), Expect = 0.26
Identities = 33/182 (18%), Positives = 80/182 (43%), Gaps = 11/182 (6%)
Query: 16 RARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLE 75
R +R + + K++E+E ++ + +++E+ +EE+ ++ L E+++ Q+ L
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 76 EEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDH-QLREAPDTAEKAKSHLEVPLEENVNR 134
E + + + R + ++E L+R+H + R + AE+ + ++ + +
Sbjct: 649 REQQERREQRLKR-----EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 135 RVLEEGSVEARTIEDAIAVLSVAEEAADRHPE----RRMRAAFTAFEEAQLPRLKQENPN 190
+ S EA + + +E R E RR R + ++E + +Q+
Sbjct: 704 WQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 191 MR 192
R
Sbjct: 763 QR 764
Score = 32.7 bits (73), Expect = 0.26
Identities = 33/190 (17%), Positives = 83/190 (43%), Gaps = 4/190 (2%)
Query: 16 RARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLE 75
R + E + D ++ E+ ++ ++ +R+++R +++ R +Q R++E +R
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER--DRKFREEEQQLRRQERERKFL 1710
Query: 76 EEDSKLKGGKAPRVATSSKVTRAQIE-DTLRRDHQLREAPDTAEKAKSHLEVPL-EENVN 133
+E+ +L+ + R + R + E + LRR + R+ + + E L + +
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 134 RRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRL 193
R+ EE + E + + + R+ R + + + + E ++L
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 194 SQLKQLLKKE 203
+ +Q L++E
Sbjct: 1831 EEQEQRLRQE 1840
Score = 32.0 bits (71), Expect = 0.44
Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 25/180 (13%)
Query: 49 KEQRKEEKEKRRLDQLE----RKKETQ----------------RLLEEEDSKLKGGKAPR 88
K+Q++ E++ R + E RK+ET R L+EE+ +L+ +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 89 VATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVE--ART 146
+ + Q + LRR+ QLR + E+ + E E+ R EE + R
Sbjct: 286 LRRERQEEEQQ-QQRLRREQQLRRKQE--EERREQQEERREQQERREQQEERREQQLRRE 342
Query: 147 IEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLR 206
E+ E+ +R ++ R E QL R +Q +L + +QL +++ LR
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR 402
Score = 31.2 bits (69), Expect = 0.74
Identities = 39/187 (20%), Positives = 85/187 (45%), Gaps = 14/187 (7%)
Query: 30 KQKELEDAYWKDDDKHVMRKEQ--RKEEKEKRRLDQLERKKETQR-LLEEEDSKLKGGKA 86
+++E + + ++ D+ + +EQ R++E++++ +Q R +E +R LEEE + +
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 87 PRVATSSKVTRAQIEDTLR---RDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSV- 142
+ + R Q R RD + RE + + + ++ +E + LEE V
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 143 ----EARTIEDAIAV-LSVAEEAADRHPERRMRAAFTAFEEAQLPRL-KQENPNMRLSQL 196
E + +ED + ++ + +R+ R +E + +L +QE L +
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 197 KQLLKKE 203
QL ++E
Sbjct: 1650 PQLRRQE 1656
Score = 30.8 bits (68), Expect = 0.97
Identities = 17/66 (25%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 6 QGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLE 65
Q + + R RAE + A K ++E E W+++++ ++ +RK +E R Q E
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRRE-EQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 66 RKKETQ 71
++ Q
Sbjct: 1892 EQRHRQ 1897
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 46.6 bits (109), Expect = 2e-05
Identities = 59/201 (29%), Positives = 86/201 (42%), Gaps = 27/201 (13%)
Query: 11 KSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKE----EKEKRRLDQL-- 64
K A A ++R E KA A K +K + DD V QR+ EK++++ DQL
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 65 ERKKETQRLLEEED-----SKLKGGKAPRVATS--------------SKVTRAQIEDTLR 105
E K + R EE D ++ K KA +A + +K RA +ED +
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 106 RDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHP 165
+ + EK+K LE +EE R LEE E + EDA L V +A
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEM--RTQLEELEDELQATEDAKLRLEVNMQAMKAQF 1576
Query: 166 ERRMRAAFTAFEEAQLPRLKQ 186
ER ++ EE + +KQ
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQ 1597
Score = 44.3 bits (103), Expect = 8e-05
Identities = 56/202 (27%), Positives = 85/202 (42%), Gaps = 28/202 (13%)
Query: 8 ENTKSAAARARRAEAKA---------AADAKKQKELEDAYWKDDDKHVMR------KEQR 52
E A A AR E KA A +AK++ E ++ + D + +M K
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 53 KEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAP--RVATSSKVTRAQIE-DTLRRDHQ 109
+ EK KR L+Q + TQ LEE + +L+ + R+ + + +AQ E D RD Q
Sbjct: 1529 ELEKSKRALEQQVEEMRTQ--LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 110 LREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIE--DAIAVLSVAEEAAD----- 162
E K LE LE+ +R L S + I+ D A + A +A D
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 163 -RHPERRMRAAFTAFEEAQLPR 183
R + +M+ EEA+ R
Sbjct: 1647 LRKLQAQMKDYQRELEEARASR 1668
Score = 35.8 bits (81), Expect = 0.030
Identities = 33/114 (28%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 20 AEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET-QRLLEEED 78
AE K AK LE D + ++++E R++ R+ QLE +K + Q EEE+
Sbjct: 1299 AEKKGIKFAKDAASLESQL--QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 79 SKLKGGKAPRVATSSKV--TRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
K + +A S++ T+ +++D L L EA K L LEE
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Score = 33.9 bits (76), Expect = 0.11
Identities = 36/164 (21%), Positives = 73/164 (44%), Gaps = 17/164 (10%)
Query: 3 KKFQGENTKSAAARARRAEAKAAAD------AKKQKELEDAYWKDDDKHVMRKEQRKEEK 56
+K GE T + + AE +A D AKK++EL+ A + DD+ + + K +
Sbjct: 1058 RKLDGETTD---LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114
Query: 57 E-KRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPD 115
E + ++ +L+ E+++ + K K ++ + + ++EDTL +E
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRD----LSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 116 TAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEE 159
E+ + L+ LEE E ++ A A+ ++E+
Sbjct: 1171 KREQEVAELKKALEEETKN---HEAQIQDMRQRHATALEELSEQ 1211
Score = 32.7 bits (73), Expect = 0.26
Identities = 45/193 (23%), Positives = 84/193 (43%), Gaps = 35/193 (18%)
Query: 11 KSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKET 70
K+ A +AE + A+A++ + A ++ ++ + E R EE+E+R KK+
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 71 QRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEE 130
Q +++ + +L E+ R+ QL + A+ K E+ L E
Sbjct: 949 QAHIQDLEEQL-----------------DEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Query: 131 NVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPN 190
+ N + ++ E + +ED IA S + A+ + + A R KQE
Sbjct: 992 DQNSKFIK----EKKLMEDRIAECS--SQLAEEEEKAKNLAKI---------RNKQE--- 1033
Query: 191 MRLSQLKQLLKKE 203
+ +S L++ LKKE
Sbjct: 1034 VMISDLEERLKKE 1046
Score = 31.6 bits (70), Expect = 0.57
Identities = 37/153 (24%), Positives = 65/153 (42%), Gaps = 20/153 (13%)
Query: 9 NTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKK 68
+T +A A R+ A+ + +A++Q E ++ K+ + E + K K + LE K
Sbjct: 1767 DTLNAELAAERSAAQKSDNARQQLERQN---KELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 69 ETQRLLEEEDSKLKGGKAPRVATSSKVTRA---QIEDTLRRDHQLREAPDTAEKAKSHLE 125
E+++K + V + K + Q+ED R Q +E + A L+
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 126 VPLEE--------NVNRRVLEEGSVEARTIEDA 150
LEE N +RR L+ R ++DA
Sbjct: 1884 RQLEEAEEEATRANASRRKLQ------RELDDA 1910
Score = 29.6 bits (65), Expect = 2.2
Identities = 34/155 (21%), Positives = 64/155 (41%), Gaps = 8/155 (5%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
E +A DAK + E+ K + ++ + E++KR L + R+ E + E +
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 81 LKGGKAPRVATSSKVTRAQIEDTLR-RDHQLREAPDTAEKAKSHLEVPLEENVNRRVL-- 137
L ++ K AQIE + RD +++ + K + E +R +
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 138 --EEGSVEARTIEDAIAVLS---VAEEAADRHPER 167
+E + +++E I L + E A RH E+
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 46.2 bits (108), Expect = 2e-05
Identities = 51/210 (24%), Positives = 95/210 (45%), Gaps = 32/210 (15%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERK 67
+ + A RA+R E + K+Q+EL + + ++R++Q +EE+++R ++L R+
Sbjct: 733 QERREAEMRAKREE----EERKRQEEL-----RRQQEEILRRQQ-EEERKRREEEELARR 782
Query: 68 KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVP 127
K+ + L + + ++ + + R Q E+ LRR + R + K + L
Sbjct: 783 KQEEALRRQREQEIALRR-----QREEEERQQQEEALRRLEERRREEEERRKQEELLR-K 836
Query: 128 LEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD-RHPE----------RRMRAAFTAF 176
EE + EE + R E+ L + EEAA RH E +R +
Sbjct: 837 QEEEAAKWAREEEEAQRRLEENR---LRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 893
Query: 177 EEAQ--LPRLKQENPNMRLSQLKQLLKKEW 204
++ Q L RL+Q+ +L+Q+K W
Sbjct: 894 QQQQEALRRLQQQQQQQQLAQMKLPSSSTW 923
Score = 42.4 bits (98), Expect = 3e-04
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 23/188 (12%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
+AKAA ++++E E + +R+EE+ KR+ + +++E R +EE+ K
Sbjct: 725 KAKAAKLEQERREAE------------MRAKREEEERKRQEELRRQQEEILRRQQEEERK 772
Query: 81 LKGGKAPRVATSSKVTRAQIED--TLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
+ + + R Q E LRR + E E+A LE E RR E
Sbjct: 773 RREEEELARRKQEEALRRQREQEIALRRQRE-EEERQQQEEALRRLEERRREEEERRKQE 831
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
E + + E+A EEA R E R+R E + RL+ E + +L+
Sbjct: 832 E--LLRKQEEEAAKWAREEEEAQRRLEENRLRM------EEEAARLRHEEEERKRKELEV 883
Query: 199 LLKKEWLR 206
+KE +R
Sbjct: 884 QRQKELMR 891
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 46.2 bits (108), Expect = 2e-05
Identities = 51/210 (24%), Positives = 95/210 (45%), Gaps = 32/210 (15%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERK 67
+ + A RA+R E + K+Q+EL + + ++R++Q +EE+++R ++L R+
Sbjct: 760 QERREAEMRAKREE----EERKRQEEL-----RRQQEEILRRQQ-EEERKRREEEELARR 809
Query: 68 KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVP 127
K+ + L + + ++ + + R Q E+ LRR + R + K + L
Sbjct: 810 KQEEALRRQREQEIALRR-----QREEEERQQQEEALRRLEERRREEEERRKQEELLR-K 863
Query: 128 LEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD-RHPE----------RRMRAAFTAF 176
EE + EE + R E+ L + EEAA RH E +R +
Sbjct: 864 QEEEAAKWAREEEEAQRRLEENR---LRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 920
Query: 177 EEAQ--LPRLKQENPNMRLSQLKQLLKKEW 204
++ Q L RL+Q+ +L+Q+K W
Sbjct: 921 QQQQEALRRLQQQQQQQQLAQMKLPSSSTW 950
Score = 42.4 bits (98), Expect = 3e-04
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 23/188 (12%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
+AKAA ++++E E + +R+EE+ KR+ + +++E R +EE+ K
Sbjct: 752 KAKAAKLEQERREAE------------MRAKREEEERKRQEELRRQQEEILRRQQEEERK 799
Query: 81 LKGGKAPRVATSSKVTRAQIED--TLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
+ + + R Q E LRR + E E+A LE E RR E
Sbjct: 800 RREEEELARRKQEEALRRQREQEIALRRQRE-EEERQQQEEALRRLEERRREEEERRKQE 858
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
E + + E+A EEA R E R+R E + RL+ E + +L+
Sbjct: 859 E--LLRKQEEEAAKWAREEEEAQRRLEENRLRM------EEEAARLRHEEEERKRKELEV 910
Query: 199 LLKKEWLR 206
+KE +R
Sbjct: 911 QRQKELMR 918
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 46.2 bits (108), Expect = 2e-05
Identities = 51/210 (24%), Positives = 95/210 (45%), Gaps = 32/210 (15%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERK 67
+ + A RA+R E + K+Q+EL + + ++R++Q +EE+++R ++L R+
Sbjct: 739 QERREAEMRAKREE----EERKRQEEL-----RRQQEEILRRQQ-EEERKRREEEELARR 788
Query: 68 KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVP 127
K+ + L + + ++ + + R Q E+ LRR + R + K + L
Sbjct: 789 KQEEALRRQREQEIALRR-----QREEEERQQQEEALRRLEERRREEEERRKQEELLR-K 842
Query: 128 LEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD-RHPE----------RRMRAAFTAF 176
EE + EE + R E+ L + EEAA RH E +R +
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENR---LRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 177 EEAQ--LPRLKQENPNMRLSQLKQLLKKEW 204
++ Q L RL+Q+ +L+Q+K W
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTW 929
Score = 42.4 bits (98), Expect = 3e-04
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 23/188 (12%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
+AKAA ++++E E + +R+EE+ KR+ + +++E R +EE+ K
Sbjct: 731 KAKAAKLEQERREAE------------MRAKREEEERKRQEELRRQQEEILRRQQEEERK 778
Query: 81 LKGGKAPRVATSSKVTRAQIED--TLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
+ + + R Q E LRR + E E+A LE E RR E
Sbjct: 779 RREEEELARRKQEEALRRQREQEIALRRQRE-EEERQQQEEALRRLEERRREEEERRKQE 837
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
E + + E+A EEA R E R+R E + RL+ E + +L+
Sbjct: 838 E--LLRKQEEEAAKWAREEEEAQRRLEENRLRM------EEEAARLRHEEEERKRKELEV 889
Query: 199 LLKKEWLR 206
+KE +R
Sbjct: 890 QRQKELMR 897
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 46.2 bits (108), Expect = 2e-05
Identities = 51/210 (24%), Positives = 95/210 (45%), Gaps = 32/210 (15%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERK 67
+ + A RA+R E + K+Q+EL + + ++R++Q +EE+++R ++L R+
Sbjct: 739 QERREAEMRAKREE----EERKRQEEL-----RRQQEEILRRQQ-EEERKRREEEELARR 788
Query: 68 KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVP 127
K+ + L + + ++ + + R Q E+ LRR + R + K + L
Sbjct: 789 KQEEALRRQREQEIALRR-----QREEEERQQQEEALRRLEERRREEEERRKQEELLR-K 842
Query: 128 LEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD-RHPE----------RRMRAAFTAF 176
EE + EE + R E+ L + EEAA RH E +R +
Sbjct: 843 QEEEAAKWAREEEEAQRRLEENR---LRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 177 EEAQ--LPRLKQENPNMRLSQLKQLLKKEW 204
++ Q L RL+Q+ +L+Q+K W
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTW 929
Score = 42.4 bits (98), Expect = 3e-04
Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 23/188 (12%)
Query: 21 EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSK 80
+AKAA ++++E E + +R+EE+ KR+ + +++E R +EE+ K
Sbjct: 731 KAKAAKLEQERREAE------------MRAKREEEERKRQEELRRQQEEILRRQQEEERK 778
Query: 81 LKGGKAPRVATSSKVTRAQIED--TLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLE 138
+ + + R Q E LRR + E E+A LE E RR E
Sbjct: 779 RREEEELARRKQEEALRRQREQEIALRRQRE-EEERQQQEEALRRLEERRREEEERRKQE 837
Query: 139 EGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQ 198
E + + E+A EEA R E R+R E + RL+ E + +L+
Sbjct: 838 E--LLRKQEEEAAKWAREEEEAQRRLEENRLRM------EEEAARLRHEEEERKRKELEV 889
Query: 199 LLKKEWLR 206
+KE +R
Sbjct: 890 QRQKELMR 897
>gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Homo
sapiens]
Length = 381
Score = 46.2 bits (108), Expect = 2e-05
Identities = 55/218 (25%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 1 MPKKFQGENTKSAAARARRA-EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKR 59
M ++ + ++ A RA+ A EAKAAA + QK K +++ + E KE + +
Sbjct: 95 MMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIK 154
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIE-DTLRRDHQLREAPDTAE 118
LE KE QR EE+ + K + K R +I+ +L R+ R
Sbjct: 155 ATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGR 214
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVE----ARTIEDAIAVLSVAEEAADRHPERRMRAAFT 174
+++ L+E+ GS++ R A+ VAEE H + R A
Sbjct: 215 NSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMN 274
Query: 175 AFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPM 212
+ A+L LK+E N EWL+ N +
Sbjct: 275 T-DIAELCDLKEEEKN-----------PEWLKDKGNKL 300
>gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Homo
sapiens]
Length = 376
Score = 46.2 bits (108), Expect = 2e-05
Identities = 55/218 (25%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 1 MPKKFQGENTKSAAARARRA-EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKR 59
M ++ + ++ A RA+ A EAKAAA + QK K +++ + E KE + +
Sbjct: 95 MMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIK 154
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIE-DTLRRDHQLREAPDTAE 118
LE KE QR EE+ + K + K R +I+ +L R+ R
Sbjct: 155 ATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGR 214
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVE----ARTIEDAIAVLSVAEEAADRHPERRMRAAFT 174
+++ L+E+ GS++ R A+ VAEE H + R A
Sbjct: 215 NSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMN 274
Query: 175 AFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPM 212
+ A+L LK+E N EWL+ N +
Sbjct: 275 T-DIAELCDLKEEEKN-----------PEWLKDKGNKL 300
>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
sapiens]
Length = 420
Score = 46.2 bits (108), Expect = 2e-05
Identities = 55/218 (25%), Positives = 89/218 (40%), Gaps = 18/218 (8%)
Query: 1 MPKKFQGENTKSAAARARRA-EAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKR 59
M ++ + ++ A RA+ A EAKAAA + QK K +++ + E KE + +
Sbjct: 95 MMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIK 154
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIE-DTLRRDHQLREAPDTAE 118
LE KE QR EE+ + K + K R +I+ +L R+ R
Sbjct: 155 ATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGR 214
Query: 119 KAKSHLEVPLEENVNRRVLEEGSVE----ARTIEDAIAVLSVAEEAADRHPERRMRAAFT 174
+++ L+E+ GS++ R A+ VAEE H + R A
Sbjct: 215 NSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMN 274
Query: 175 AFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPM 212
+ A+L LK+E N EWL+ N +
Sbjct: 275 T-DIAELCDLKEEEKN-----------PEWLKDKGNKL 300
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 45.1 bits (105), Expect = 5e-05
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 23/198 (11%)
Query: 12 SAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQ 71
SA+ +R E AA + + E D R+EQR E++E+RR + E Q
Sbjct: 293 SASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQR-EQRERRRAAKEEELLRLQ 351
Query: 72 RLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRR----------DHQLREAPDTAEKAK 121
+L EE++ KL+ + + A Q E+ RR + QLREA +
Sbjct: 352 QLQEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQ 411
Query: 122 SHLEVPLEENVNRRV-LEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQ 180
+ +E+ EE +R ++E + +++A+ + E R E +R A T E +
Sbjct: 412 AEMELKEEEAARQRQRIKELEEMQQRLQEALQL-----EVKARRDEESVRIAQTRLLEEE 466
Query: 181 LPRLKQENPNMRLSQLKQ 198
+LKQ L QLK+
Sbjct: 467 EEKLKQ------LMQLKE 478
Score = 28.5 bits (62), Expect = 4.8
Identities = 22/106 (20%), Positives = 46/106 (43%), Gaps = 1/106 (0%)
Query: 8 ENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERK 67
E + A + E KA D + + + +++++ + + Q KEE+E+ + K
Sbjct: 432 EEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEK 491
Query: 68 KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREA 113
+E Q+ + ++ L+ + RA ED +LR+A
Sbjct: 492 EELQQEMAQQSRSLQQAQQQLEEVRQNRQRAD-EDVEAAQRKLRQA 536
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 17/167 (10%)
Query: 49 KEQRKEEKEKRRLDQLERK-KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQ---IEDTL 104
K++ K K++L LE K K+ + L+E+ ++ + ++ ++ R + ++
Sbjct: 1532 KDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEME 1591
Query: 105 RRDHQLREAPDTAEKAKSHLEVPLEENV--NRRVLEEGSVEARTIEDAIAVLSVAEEAAD 162
RD ++ EA + +K +EV LEE ++VL E R +E +A LS D
Sbjct: 1592 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR----EKRELEGKLATLSDQVNRRD 1647
Query: 163 RHPERRMR------AAFTAFEEAQLPRLKQENPNMR-LSQLKQLLKK 202
E+R+R A A + L LK P+ R ++QLK L++
Sbjct: 1648 FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEE 1694
Score = 30.8 bits (68), Expect = 0.97
Identities = 31/145 (21%), Positives = 67/145 (46%), Gaps = 7/145 (4%)
Query: 49 KEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVAT-----SSKVTRAQIEDT 103
++Q K + E+R D +E+QR L++ K + A T +V ++E
Sbjct: 1400 EQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKK 1459
Query: 104 LRR-DHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD 162
RR D +L +A + A++ K E L+ + + E S++ + E + + ++
Sbjct: 1460 QRRFDSELSQAHEEAQREKLQRE-KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVS 1518
Query: 163 RHPERRMRAAFTAFEEAQLPRLKQE 187
E + ++ + +EA L ++K++
Sbjct: 1519 LEAELQDISSQESKDEASLAKVKKQ 1543
Score = 29.6 bits (65), Expect = 2.2
Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 36/206 (17%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEED 78
+A+ + + ++ ++ + D+ V Q ++K K+ QLE + E ++ + E
Sbjct: 1570 QAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK 1629
Query: 79 SKLKGGKA--------------PRVATSSKVTRAQIEDT-LRRDHQLREAPDTAEKAKSH 123
+L+G A R+ K T+A + D L DH AP E A+
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQ-- 1687
Query: 124 LEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPE-RRMRAAFTAFEEAQLP 182
L+ LEE+ +V+AR ++ E D H + + A TA EE QL
Sbjct: 1688 LKNQLEES---EFTCAAAVKARK--------AMEVEIEDLHLQIDDIAKAKTALEE-QLS 1735
Query: 183 RLKQENPNM--RLSQ----LKQLLKK 202
RL++E + RL + + +L+KK
Sbjct: 1736 RLQREKNEIQNRLEEDQEDMNELMKK 1761
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 45.1 bits (105), Expect = 5e-05
Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 17/167 (10%)
Query: 49 KEQRKEEKEKRRLDQLERK-KETQRLLEEEDSKLKGGKAPRVATSSKVTRAQ---IEDTL 104
K++ K K++L LE K K+ + L+E+ ++ + ++ ++ R + ++
Sbjct: 1532 KDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEME 1591
Query: 105 RRDHQLREAPDTAEKAKSHLEVPLEENV--NRRVLEEGSVEARTIEDAIAVLSVAEEAAD 162
RD ++ EA + +K +EV LEE ++VL E R +E +A LS D
Sbjct: 1592 SRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR----EKRELEGKLATLSDQVNRRD 1647
Query: 163 RHPERRMR------AAFTAFEEAQLPRLKQENPNMR-LSQLKQLLKK 202
E+R+R A A + L LK P+ R ++QLK L++
Sbjct: 1648 FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEE 1694
Score = 30.8 bits (68), Expect = 0.97
Identities = 31/145 (21%), Positives = 67/145 (46%), Gaps = 7/145 (4%)
Query: 49 KEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVAT-----SSKVTRAQIEDT 103
++Q K + E+R D +E+QR L++ K + A T +V ++E
Sbjct: 1400 EQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKK 1459
Query: 104 LRR-DHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAAD 162
RR D +L +A + A++ K E L+ + + E S++ + E + + ++
Sbjct: 1460 QRRFDSELSQAHEEAQREKLQRE-KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVS 1518
Query: 163 RHPERRMRAAFTAFEEAQLPRLKQE 187
E + ++ + +EA L ++K++
Sbjct: 1519 LEAELQDISSQESKDEASLAKVKKQ 1543
Score = 29.6 bits (65), Expect = 2.2
Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 36/206 (17%)
Query: 19 RAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEED 78
+A+ + + ++ ++ + D+ V Q ++K K+ QLE + E ++ + E
Sbjct: 1570 QAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK 1629
Query: 79 SKLKGGKA--------------PRVATSSKVTRAQIEDT-LRRDHQLREAPDTAEKAKSH 123
+L+G A R+ K T+A + D L DH AP E A+
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQ-- 1687
Query: 124 LEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPE-RRMRAAFTAFEEAQLP 182
L+ LEE+ +V+AR ++ E D H + + A TA EE QL
Sbjct: 1688 LKNQLEES---EFTCAAAVKARK--------AMEVEIEDLHLQIDDIAKAKTALEE-QLS 1735
Query: 183 RLKQENPNM--RLSQ----LKQLLKK 202
RL++E + RL + + +L+KK
Sbjct: 1736 RLQREKNEIQNRLEEDQEDMNELMKK 1761
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 44.7 bits (104), Expect = 6e-05
Identities = 46/222 (20%), Positives = 96/222 (43%), Gaps = 29/222 (13%)
Query: 7 GENTKSAAARARRAEAKAAADA-KKQKELEDAYWKDDD---KHVMRKEQRK---EEKEKR 59
GE+T + E K+ ++A K+Q++L+ +D + KH++ + QR+ +++E+R
Sbjct: 347 GESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERR 406
Query: 60 RLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEK 119
R+++ +R++ QR L+E++ + R + LRR+ + R+A E
Sbjct: 407 RVEEQQRREREQRKLQEKEQQ---------------RRLEDMQALRREEERRQAEREQEY 451
Query: 120 AKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEE------AADRHPERRMRAAF 173
+ LE + +R L++ ++++ + ++ DR P
Sbjct: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
Query: 174 TAFEEAQLPRLKQENPNMRLSQLKQLLK-KEWLRSPDNPMNQ 214
++ R +E M Q L K K P+ P+ Q
Sbjct: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQ 553
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,015,681
Number of Sequences: 37866
Number of extensions: 361528
Number of successful extensions: 8573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 319
Number of HSP's successfully gapped in prelim test: 617
Number of HSP's that attempted gapping in prelim test: 3730
Number of HSP's gapped (non-prelim): 2927
length of query: 223
length of database: 18,247,518
effective HSP length: 98
effective length of query: 125
effective length of database: 14,536,650
effective search space: 1817081250
effective search space used: 1817081250
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.