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Search of human proteins with 19923812
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923812 oxysterol-binding protein-like protein 10 [Homo
sapiens]
(764 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi... 1549 0.0
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens] 788 0.0
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 428 e-119
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap... 428 e-119
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap... 428 e-119
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap... 428 e-119
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap... 428 e-119
gi|22547167 oxysterol binding protein-like 9 isoform a [Homo sap... 428 e-119
gi|22547165 oxysterol binding protein-like 9 isoform a [Homo sap... 428 e-119
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [... 218 2e-56
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [... 218 2e-56
gi|14149740 oxysterol-binding protein-like protein 5 isoform a [... 217 3e-56
gi|221136766 oxysterol-binding protein-like protein 5 isoform b ... 217 3e-56
gi|22035609 oxysterol-binding protein-like protein 5 isoform b [... 217 3e-56
gi|4505531 oxysterol binding protein [Homo sapiens] 110 4e-24
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 108 2e-23
gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo sa... 107 3e-23
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [... 100 9e-21
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [... 100 9e-21
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens] 99 1e-20
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens] 96 2e-19
gi|21450853 oxysterol-binding protein-like protein 2 isoform 2 [... 94 6e-19
gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [H... 94 6e-19
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [... 92 2e-18
gi|21735582 oxysterol-binding protein-like protein 3 isoform c [... 91 3e-18
gi|21735580 oxysterol-binding protein-like protein 3 isoform b [... 89 1e-17
gi|14149704 oxysterol-binding protein-like protein 3 isoform a [... 89 1e-17
gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ... 64 5e-10
gi|54792084 pleckstrin homology domain containing, family A (pho... 52 2e-06
gi|14165452 alpha 3 type IV collagen binding protein isoform 2 [... 52 3e-06
>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
sapiens]
Length = 764
Score = 1549 bits (4011), Expect = 0.0
Identities = 764/764 (100%), Positives = 764/764 (100%)
Query: 1 MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGS 60
MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGS
Sbjct: 1 MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGS 60
Query: 61 VAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRG 120
VAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRG
Sbjct: 61 VAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRG 120
Query: 121 VLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKS 180
VLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKS
Sbjct: 121 VLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKS 180
Query: 181 APSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHE 240
APSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHE
Sbjct: 181 APSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHE 240
Query: 241 VREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSV 300
VREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSV
Sbjct: 241 VREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSV 300
Query: 301 HQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTS 360
HQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTS
Sbjct: 301 HQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTS 360
Query: 361 QPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPT 420
QPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPT
Sbjct: 361 QPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPT 420
Query: 421 FILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYN 480
FILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYN
Sbjct: 421 FILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYN 480
Query: 481 PIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPIS 540
PIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPIS
Sbjct: 481 PIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPIS 540
Query: 541 CFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSIL 600
CFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSIL
Sbjct: 541 CFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSIL 600
Query: 601 TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWN 660
TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWN
Sbjct: 601 TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWN 660
Query: 661 GTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQ 720
GTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQ
Sbjct: 661 GTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQ 720
Query: 721 KRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH 764
KRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH
Sbjct: 721 KRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH 764
>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
Length = 747
Score = 788 bits (2034), Expect = 0.0
Identities = 406/718 (56%), Positives = 501/718 (69%), Gaps = 20/718 (2%)
Query: 51 GGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVN 110
GGG SS S S G + G L KYTNL+ GWQ R+FVL+ EAG+L+YFVN
Sbjct: 35 GGGISSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVN 94
Query: 111 EQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACA 170
EQS++QKPRG L L+GA++S SDE H V +A+GE +KLRA DAKE+Q WV++L+ C
Sbjct: 95 EQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICT 154
Query: 171 KYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRA 230
++H E K+ P +SRS +L +S SP SQR S A + H K + ++R
Sbjct: 155 QHHTEAIGKNNPPLKSRSFSL----ASSSNSPISQRRPSQNAISFFNVGHSKLQSLSKRT 210
Query: 231 KSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLG 290
L EVREMM+ EGQQ++L+ IE LP SG L++LDQDLL+LKATS AT++CL
Sbjct: 211 NLP-PDHLVEVREMMSHAEGQQRDLIRRIECLPTSGHLSSLDQDLLMLKATSMATMNCLN 269
Query: 291 ECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAIL 350
+C ++LQ H + Q P S + W K + KNG P A+ +
Sbjct: 270 DCFHILQLQ-HASHQKGSLP--SGTTIEWLEPKISLSNHYKNGA--DQPFATDQSKPVAV 324
Query: 351 PNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLG 410
P ++ EP E + ++DE D D +E +LG +E+QRS+ILHL+SQLKLG
Sbjct: 325 PEEQPVAESGLLAREP----EEINADDEIEDTCDHKEDDLGAVEEQRSVILHLLSQLKLG 380
Query: 411 MDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGR 470
MDLT+VVLPTFILEKRSLLEMYADFM+HPDL +AIT GAT E+R+I FVEYYLT+FHEGR
Sbjct: 381 MDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGR 440
Query: 471 KGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEH-PMADDP-----SKSY 524
KGA+AKKPYNPIIGETFHCSW++PK V +S S H P++ + S Y
Sbjct: 441 KGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSDCY 500
Query: 525 KLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHG 584
+RFVAEQVSHHPP+S FY EC E+++CVN HVWTKSKF+GMS+GV+M+GEG+L LLEHG
Sbjct: 501 TVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHG 560
Query: 585 EEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVK 644
EEY F+LP AYARSILT+PWVELGGKVS+NCAKTGYSA++ FHTKPFYGGK+HRVTAEVK
Sbjct: 561 EEYTFSLPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVK 620
Query: 645 HNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWRE 704
HN TNT+VC+ GEWN LEFTY+NGETK +D T L V K++RPLEKQ P ESR LW+
Sbjct: 621 HNITNTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKN 680
Query: 705 VTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
VT LR +ID ATE K LEE+QR EER R TPWK KYFI+EGDGWVY PLWK
Sbjct: 681 VTDSLRESEIDKATEHKHTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWK 738
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 319 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 378
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 379 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 438
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 439 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 491
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 492 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 549
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 550 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 609
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 610 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 669
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 670 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 729
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 2/98 (2%)
Query: 77 LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVN-EQSKHQKPRGVLSLSGAIVSLSDEA 135
+EG LSK+TN+++GWQ R+FVLD+ AG+L Y+ + ++ RG + L GA++ + DE
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 136 PHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYH 173
+ + + + F +A DA E++ W+ L H
Sbjct: 65 DSTFTI-TVDQKTFHFQARDADEREKWIHALEETILRH 101
>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
sapiens]
Length = 746
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 329 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 388
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 389 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 448
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 449 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 501
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 502 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 559
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 560 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 619
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 620 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 679
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 680 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 739
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 2/98 (2%)
Query: 77 LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVN-EQSKHQKPRGVLSLSGAIVSLSDEA 135
+EG LSK+TN+++GWQ R+FVLD+ AG+L Y+ + ++ RG + L GA++ + DE
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 136 PHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYH 173
+ + + + F +A DA E++ W+ L H
Sbjct: 65 DSTFTI-TVDQKTFHFQARDADEREKWIHALEETILRH 101
>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
sapiens]
Length = 723
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 306 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 365
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 366 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 425
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 426 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 478
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 479 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 536
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 537 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 596
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 597 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 656
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 657 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 716
Score = 70.5 bits (171), Expect = 6e-12
Identities = 34/98 (34%), Positives = 58/98 (59%), Gaps = 2/98 (2%)
Query: 77 LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVN-EQSKHQKPRGVLSLSGAIVSLSDEA 135
+EG LSK+TN+++GWQ R+FVLD+ AG+L Y+ + ++ RG + L GA++ + DE
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 136 PHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYH 173
+ + + + F +A DA E++ W+ L H
Sbjct: 65 DSTFTI-TVDQKTFHFQARDADEREKWIHALEETILRH 101
>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
sapiens]
Length = 626
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 209 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 268
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 269 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 328
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 329 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 381
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 382 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 439
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 440 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 499
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 500 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 559
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 560 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 619
>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
sapiens]
Length = 571
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 154 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 213
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 214 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 273
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 274 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 326
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 327 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 384
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 385 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 444
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 445 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 504
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 505 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 564
>gi|22547167 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 141 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 200
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 201 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 260
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 261 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 313
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 314 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 371
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 372 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 431
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 432 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 491
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 492 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 551
>gi|22547165 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 428 bits (1100), Expect = e-119
Identities = 210/420 (50%), Positives = 282/420 (67%), Gaps = 14/420 (3%)
Query: 348 AILPNSAEDEQTSQPEPEPNSGSELV--LSEDEKSDNEDK--EETELGVMEDQRSIILHL 403
++L +S+ +P+ + S L S+ + D+ D ++ E G +E+ +S+I+HL
Sbjct: 141 SVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGSVEEHKSVIMHL 200
Query: 404 ISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYL 463
+SQ++LGMDLTKVVLPTFILE+RSLLEMYADF AHPDL ++I+ P++R++ V++YL
Sbjct: 201 LSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYL 260
Query: 464 TAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKS 523
+AFH GRKG++AKKPYNPI+GE F C W +P D + S P P S
Sbjct: 261 SAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPV-----PWVSKNS-- 313
Query: 524 YKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEH 583
+ FVAEQVSHHPPIS FY EC K++ N H+WTKSKF+GMS+GV IG+G + L++
Sbjct: 314 --VTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY 371
Query: 584 GEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEV 643
E Y+ T P+ Y RSILT+PWVELGG+ +INC+KTGYSA +IFHTKPFYGGK HR+TAE+
Sbjct: 372 DEHYILTFPNGYGRSILTVPWVELGGECNINCSKTGYSANIIFHTKPFYGGKKHRITAEI 431
Query: 644 KHNPTNTIVCKAHGEWNGTLEFTYNNGETKV-IDTTTLPVYPKKIRPLEKQGPMESRNLW 702
C GEWNG + Y GE V +DT LP+ KK+R LE Q ESR+LW
Sbjct: 432 FSPNDKKSFCSIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKKVRKLEDQNEYESRSLW 491
Query: 703 REVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWK 762
++VT L++ DIDAATE K LEE+QR E R+R+ W+ + F ++G+ WVY PL K
Sbjct: 492 KDVTFNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDGECWVYDEPLLK 551
>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
[Homo sapiens]
Length = 847
Score = 218 bits (554), Expect = 2e-56
Identities = 144/408 (35%), Positives = 207/408 (50%), Gaps = 43/408 (10%)
Query: 352 NSAEDEQTSQPEPEP----NSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQL 407
+++E + S EPEP + S +E + + +TE V E+ +S+I L+ Q+
Sbjct: 314 DTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTET-VSEENKSLIWTLLKQV 372
Query: 408 KLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFH 467
+ GMDL+KVVLPTFILE RS L+ +D+ H D L P R+ V++YL+ F+
Sbjct: 373 RPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFY 432
Query: 468 EGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLR 527
+ KG KKPYNPI+GETF C W P+ SK++
Sbjct: 433 KKPKGL--KKPYNPILGETFRCLWIHPRTN-----------------------SKTF--- 464
Query: 528 FVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEY 587
++AEQVSHHPPIS FY + C++ + KSKF G S+ + GE L L GE+Y
Sbjct: 465 YIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDY 524
Query: 588 VFTLPSAYARSIL-TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGK--VHRVTAEVK 644
V T+P A+ + IL +ELGG V+I C KTGYSA + F KPF G V++++ ++K
Sbjct: 525 VMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLK 584
Query: 645 HNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYP--KKIR---PLEKQGPMESR 699
++ G W+ + T + + P + IR E+QG ES
Sbjct: 585 LG--KEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESE 642
Query: 700 NLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
LW+ VTR + D AT++K LEE QR R R+ W K F
Sbjct: 643 KLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLF 690
>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
[Homo sapiens]
Length = 889
Score = 218 bits (554), Expect = 2e-56
Identities = 144/408 (35%), Positives = 207/408 (50%), Gaps = 43/408 (10%)
Query: 352 NSAEDEQTSQPEPEP----NSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQL 407
+++E + S EPEP + S +E + + +TE V E+ +S+I L+ Q+
Sbjct: 356 DTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTET-VSEENKSLIWTLLKQV 414
Query: 408 KLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFH 467
+ GMDL+KVVLPTFILE RS L+ +D+ H D L P R+ V++YL+ F+
Sbjct: 415 RPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFY 474
Query: 468 EGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLR 527
+ KG KKPYNPI+GETF C W P+ SK++
Sbjct: 475 KKPKGL--KKPYNPILGETFRCLWIHPRTN-----------------------SKTF--- 506
Query: 528 FVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEY 587
++AEQVSHHPPIS FY + C++ + KSKF G S+ + GE L L GE+Y
Sbjct: 507 YIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDY 566
Query: 588 VFTLPSAYARSIL-TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGK--VHRVTAEVK 644
V T+P A+ + IL +ELGG V+I C KTGYSA + F KPF G V++++ ++K
Sbjct: 567 VMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKLK 626
Query: 645 HNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYP--KKIR---PLEKQGPMESR 699
++ G W+ + T + + P + IR E+QG ES
Sbjct: 627 LG--KEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVKFEEQGDFESE 684
Query: 700 NLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
LW+ VTR + D AT++K LEE QR R R+ W K F
Sbjct: 685 KLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLF 732
>gi|14149740 oxysterol-binding protein-like protein 5 isoform a
[Homo sapiens]
Length = 879
Score = 217 bits (553), Expect = 3e-56
Identities = 133/397 (33%), Positives = 200/397 (50%), Gaps = 34/397 (8%)
Query: 357 EQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKV 416
+Q+ P G+ V E+ + V E+ +S++ L+ QL+ GMDL++V
Sbjct: 328 DQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV 387
Query: 417 VLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAK 476
VLPTF+LE RS L +D+ H DLL R+ + +YL+ F++ KG K
Sbjct: 388 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGI--K 445
Query: 477 KPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHH 536
KPYNPI+GETF C W HP D S+++ ++AEQVSHH
Sbjct: 446 KPYNPILGETFRCCWF---------------------HPQTD--SRTF---YIAEQVSHH 479
Query: 537 PPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYA 596
PP+S F+ + C++ + KS+F G S+ + G+ L L E+Y T+P A+
Sbjct: 480 PPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHC 539
Query: 597 RSIL-TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKA 655
+ IL +ELGGKV+I CAK + A + F KPF+GG K ++
Sbjct: 540 KGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASL 599
Query: 656 HGEWNGTLEF-TYNNGETKVIDTTTLPVYPKKIR----PLEKQGPMESRNLWREVTRYLR 710
G W+ + +G + + T + V +++R PLE+Q +ES LW+ VTR +
Sbjct: 600 SGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAIS 659
Query: 711 LGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
GD AT++K LEE QR R+R+ PWKP+ F
Sbjct: 660 KGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF 696
>gi|221136766 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 217 bits (553), Expect = 3e-56
Identities = 133/397 (33%), Positives = 200/397 (50%), Gaps = 34/397 (8%)
Query: 357 EQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKV 416
+Q+ P G+ V E+ + V E+ +S++ L+ QL+ GMDL++V
Sbjct: 260 DQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV 319
Query: 417 VLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAK 476
VLPTF+LE RS L +D+ H DLL R+ + +YL+ F++ KG K
Sbjct: 320 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGI--K 377
Query: 477 KPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHH 536
KPYNPI+GETF C W HP D S+++ ++AEQVSHH
Sbjct: 378 KPYNPILGETFRCCWF---------------------HPQTD--SRTF---YIAEQVSHH 411
Query: 537 PPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYA 596
PP+S F+ + C++ + KS+F G S+ + G+ L L E+Y T+P A+
Sbjct: 412 PPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHC 471
Query: 597 RSIL-TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKA 655
+ IL +ELGGKV+I CAK + A + F KPF+GG K ++
Sbjct: 472 KGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASL 531
Query: 656 HGEWNGTLEF-TYNNGETKVIDTTTLPVYPKKIR----PLEKQGPMESRNLWREVTRYLR 710
G W+ + +G + + T + V +++R PLE+Q +ES LW+ VTR +
Sbjct: 532 SGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAIS 591
Query: 711 LGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
GD AT++K LEE QR R+R+ PWKP+ F
Sbjct: 592 KGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF 628
>gi|22035609 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 217 bits (553), Expect = 3e-56
Identities = 133/397 (33%), Positives = 200/397 (50%), Gaps = 34/397 (8%)
Query: 357 EQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKV 416
+Q+ P G+ V E+ + V E+ +S++ L+ QL+ GMDL++V
Sbjct: 260 DQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRV 319
Query: 417 VLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAK 476
VLPTF+LE RS L +D+ H DLL R+ + +YL+ F++ KG K
Sbjct: 320 VLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGI--K 377
Query: 477 KPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHH 536
KPYNPI+GETF C W HP D S+++ ++AEQVSHH
Sbjct: 378 KPYNPILGETFRCCWF---------------------HPQTD--SRTF---YIAEQVSHH 411
Query: 537 PPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYA 596
PP+S F+ + C++ + KS+F G S+ + G+ L L E+Y T+P A+
Sbjct: 412 PPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHC 471
Query: 597 RSIL-TIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKA 655
+ IL +ELGGKV+I CAK + A + F KPF+GG K ++
Sbjct: 472 KGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASL 531
Query: 656 HGEWNGTLEF-TYNNGETKVIDTTTLPVYPKKIR----PLEKQGPMESRNLWREVTRYLR 710
G W+ + +G + + T + V +++R PLE+Q +ES LW+ VTR +
Sbjct: 532 SGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAIS 591
Query: 711 LGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
GD AT++K LEE QR R+R+ PWKP+ F
Sbjct: 592 KGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF 628
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 110 bits (276), Expect = 4e-24
Identities = 181/797 (22%), Positives = 305/797 (38%), Gaps = 146/797 (18%)
Query: 10 GGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGG 69
GGGG + S A S G+ + + G G A G+ G +P + + SG G
Sbjct: 31 GGGGGRGDAGPGSGAAS-GTVVAAAAGGPG----PGAGGVAAAGPAPAPPTGGSGGSGAG 85
Query: 70 GRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIV 129
G A EG L K+TN ++G+Q R+FVL G+L Y+ ++ RG ++L+ A +
Sbjct: 86 GSGS--AREGWLFKWTNYIKGYQRRWFVL--SNGLLSYYRSKAEMRHTCRGTINLATANI 141
Query: 130 SLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSL 189
++ D ++ + + + L+A+ E+Q WVT L ++M ++S S S+
Sbjct: 142 TVEDSC--NFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESV 199
Query: 190 TLLPHGTPNSASPCSQRHLSVGAPGVVTITH--HKSPAAARRAKSQYSGQLHEVREMMNQ 247
+ T + + R LS + T K A +R+ L E+ +
Sbjct: 200 S----QTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRS-------LSELESLKLP 248
Query: 248 VEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPS 307
E +K + +++ L + TS A ++ + L +L Q+ + Q S
Sbjct: 249 AESNEK--------------IKQVNERATLFRITSNAMINACRDFL-MLAQTHSKKWQKS 293
Query: 308 ------QKPGASENILGWHGSKSHSTEQLKNGTL------GSLPSASANITWAILPNSAE 355
Q+ E + +H + T+ G++ S S E
Sbjct: 294 LQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDE 353
Query: 356 DEQT---SQPE----PE----PNSGSELV-LSEDEKSDNEDKEETELGVMEDQRSI---- 399
D++ PE PE +GS + S D D + K + E E + I
Sbjct: 354 DDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKP 413
Query: 400 --ILHLISQLK--LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERV 455
L+L S +K +G +L+K+ +P E S+L+ + + + +LL E+
Sbjct: 414 NYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQ- 472
Query: 456 ICFV------EYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPA 509
+C+V Y T F KP+NP++GETF
Sbjct: 473 LCYVAAFTVSSYSTTVFR-------TSKPFNPLLGETFEL-------------------- 505
Query: 510 SCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVG 569
D + R + EQVSHHPP + + E + + + SKF G +
Sbjct: 506 ---------DRLEENGYRSLCEQVSHHPPAAAHHAE-SKNGWTLRQEIKITSKFRGKYLS 555
Query: 570 VSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVELGGKVSINCAKTGYSATVIFHT 628
+ +G G Y + + +I+ W++ G++ I KTG + F
Sbjct: 556 IMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVP 615
Query: 629 KPFYGGKVHR-VTAEVKHNPTNTIVCKAHGEWNGTLE-------FTYNNGETKV--IDTT 678
++ V R VT EV +P+ + G W+ +E N G+ + +
Sbjct: 616 YSYFSRDVARKVTGEVT-DPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAE 674
Query: 679 TLPVYPKKIRPLEKQGP--------MESRNLWREVT-----------RYLRLGDIDAATE 719
V K PL K + N W T R + G D A
Sbjct: 675 ESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANA 734
Query: 720 QKRHLEEKQRVEERKRE 736
+K+ LEEKQR+ +KRE
Sbjct: 735 EKQRLEEKQRLSRKKRE 751
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 108 bits (270), Expect = 2e-23
Identities = 112/453 (24%), Positives = 187/453 (41%), Gaps = 73/453 (16%)
Query: 273 QDLLLLKATSAATLSCLGECLNLL--QQSVH--QAGQPSQKPGASENILGWHGSKSHSTE 328
Q + ++ S T L +CLNL Q+ V + Q +K L ++ H E
Sbjct: 399 QKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELE 458
Query: 329 QLKNGTLGSLPSA--SANITWAILPNSAEDEQTSQPEPEP-----NSGSELVLSEDEKSD 381
Q + GS P++ S + + L +S + S+ E G L + S+
Sbjct: 459 Q--SLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSE 516
Query: 382 NED------------KEETEL-GVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSL 428
+D K T L M + + I + +GM+L+K+ +P E S
Sbjct: 517 EKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSF 576
Query: 429 LEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFH 488
L+ ++M H L+ ++ + P ER+ C + ++A + KP+NP++GET+
Sbjct: 577 LQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAV--ASQWERTGKPFNPLLGETY- 633
Query: 489 CSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEE 548
E+ +D + R ++EQVSHHPPIS F+ E
Sbjct: 634 ---ELVRDDLG--------------------------FRLISEQVSHHPPISAFHAEGLN 664
Query: 549 KRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVEL 607
+ ++ K KF G SV G L LLEH E Y +T P+ +I+ W+E
Sbjct: 665 NDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQ 724
Query: 608 GGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTY 667
G V I KTG + F +G ++H+V ++ + + +C +G+W E Y
Sbjct: 725 YGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQ-DKSKKKLCALYGKWT---ECLY 780
Query: 668 NNGETKVIDTTTLPVYPKKIRPLEKQGPMESRN 700
+ +D T Y K +K+ E +N
Sbjct: 781 S------VDPATFDAYKKN----DKKNTEEKKN 803
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 6/61 (9%)
Query: 707 RYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQ------EGDGWVYFNPL 760
R + G+ID A+E+K+ LEEKQR + R WK ++F Q W+Y
Sbjct: 879 RAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 938
Query: 761 W 761
W
Sbjct: 939 W 939
>gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo
sapiens]
Length = 437
Score = 107 bits (268), Expect = 3e-23
Identities = 86/326 (26%), Positives = 142/326 (43%), Gaps = 48/326 (14%)
Query: 377 DEKSDNEDKEETEL-GVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADF 435
D S+ K T L M + + I + +GM+L+K+ +P E S L+ ++
Sbjct: 11 DALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEY 70
Query: 436 MAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPK 495
M H L+ ++ + P ER+ C + ++A + KP+NP++GET+ E+ +
Sbjct: 71 MEHTYLIHKASSLSDPVERMQCVAAFAVSAV--ASQWERTGKPFNPLLGETY----ELVR 124
Query: 496 DRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNT 555
D + R ++EQVSHHPPIS F+ E +
Sbjct: 125 DDLG--------------------------FRLISEQVSHHPPISAFHAEGLNNDFIFHG 158
Query: 556 HVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVELGGKVSIN 614
++ K KF G SV G L LLEH E Y +T P+ +I+ W+E G V I
Sbjct: 159 SIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEII 218
Query: 615 CAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKV 674
KTG + F +G ++H+V ++ + + +C +G+W E Y+
Sbjct: 219 NHKTGDKCVLNFKPCGLFGKELHKVEGYIQ-DKSKKKLCALYGKWT---ECLYS------ 268
Query: 675 IDTTTLPVYPKKIRPLEKQGPMESRN 700
+D T Y K +K+ E +N
Sbjct: 269 VDPATFDAYKKN----DKKNTEEKKN 290
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 6/61 (9%)
Query: 707 RYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQ------EGDGWVYFNPL 760
R + G+ID A+E+K+ LEEKQR + R WK ++F Q W+Y
Sbjct: 366 RAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSY 425
Query: 761 W 761
W
Sbjct: 426 W 426
>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
[Homo sapiens]
Length = 938
Score = 99.8 bits (247), Expect = 9e-21
Identities = 98/394 (24%), Positives = 164/394 (41%), Gaps = 66/394 (16%)
Query: 395 DQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEER 454
D +I L I + +G DL+KV +P + E + L+ + M + +LL + P ER
Sbjct: 569 DTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYER 628
Query: 455 VICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEH 514
++ + ++ + A KP+NP++GET+ C E
Sbjct: 629 MVLVAAFAVSGYCSTYFRA-GSKPFNPVLGETYECIRE---------------------- 665
Query: 515 PMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIG 574
K + RF +EQVSHHPPIS C CE K + K+KF G S+ + +G
Sbjct: 666 ------DKGF--RFFSEQVSHHPPISA--CHCESKNFVFWQDIRWKNKFWGKSMEILPVG 715
Query: 575 EGVLRLLEHGEEYVFTLPSAYARSILT-IPWVELGGKVSINCAKTGYSATVIFHTKPFYG 633
+ L ++G+ YV+ + +IL+ W+E G+V+I K+ + K Y
Sbjct: 716 TLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYW 775
Query: 634 GKVHRVTAEVKHNPTNTIVCKAHGEWN-----------------GTLEFTYN--NGETK- 673
V + V + G+W+ G++ Y G T+
Sbjct: 776 NSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRF 835
Query: 674 VIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEER 733
I+ L K + P P ++R +R R+L G+++AA +K+ +EE QR R
Sbjct: 836 AIELNELDPVLKDLLP-----PTDAR--FRPDQRFLEEGNLEAAASEKQRVEELQRSRRR 888
Query: 734 KRENLRTPWKPKYF-----IQEGDGWVYFNPLWK 762
E PK+F + + WV + W+
Sbjct: 889 YMEENNLEHIPKFFKKVIDANQREAWVSNDTYWE 922
Score = 33.1 bits (74), Expect = 0.99
Identities = 46/205 (22%), Positives = 85/205 (41%), Gaps = 22/205 (10%)
Query: 88 LQGWQNRYFVLDFEAGILQYF-VNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANG 146
L+GW R+FVLD G+L+Y + K G + + +++S+ +A +
Sbjct: 80 LKGWHKRFFVLD--NGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARR--IDLDTEE 135
Query: 147 EMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQR 206
++ L+ WV++LR + + ++ S R S + P + +SP +
Sbjct: 136 HIYHLKVKSQDWFDAWVSKLR---HHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANV 192
Query: 207 HLSVGA------PGVVTITHHKS-PAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAI 259
+ G P + S PA +S+ + L + EM E +L H
Sbjct: 193 SVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAE----DLAHCQ 248
Query: 260 ESLPGSGPLTALDQDLLLLKATSAA 284
+L L+ L Q+L +L+ T +A
Sbjct: 249 SNLV---ELSKLLQNLEILQRTQSA 270
>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
[Homo sapiens]
Length = 934
Score = 99.8 bits (247), Expect = 9e-21
Identities = 98/394 (24%), Positives = 164/394 (41%), Gaps = 66/394 (16%)
Query: 395 DQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEER 454
D +I L I + +G DL+KV +P + E + L+ + M + +LL + P ER
Sbjct: 565 DTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYER 624
Query: 455 VICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEH 514
++ + ++ + A KP+NP++GET+ C E
Sbjct: 625 MVLVAAFAVSGYCSTYFRA-GSKPFNPVLGETYECIRE---------------------- 661
Query: 515 PMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIG 574
K + RF +EQVSHHPPIS C CE K + K+KF G S+ + +G
Sbjct: 662 ------DKGF--RFFSEQVSHHPPISA--CHCESKNFVFWQDIRWKNKFWGKSMEILPVG 711
Query: 575 EGVLRLLEHGEEYVFTLPSAYARSILT-IPWVELGGKVSINCAKTGYSATVIFHTKPFYG 633
+ L ++G+ YV+ + +IL+ W+E G+V+I K+ + K Y
Sbjct: 712 TLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYW 771
Query: 634 GKVHRVTAEVKHNPTNTIVCKAHGEWN-----------------GTLEFTYN--NGETK- 673
V + V + G+W+ G++ Y G T+
Sbjct: 772 NSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRF 831
Query: 674 VIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEER 733
I+ L K + P P ++R +R R+L G+++AA +K+ +EE QR R
Sbjct: 832 AIELNELDPVLKDLLP-----PTDAR--FRPDQRFLEEGNLEAAASEKQRVEELQRSRRR 884
Query: 734 KRENLRTPWKPKYF-----IQEGDGWVYFNPLWK 762
E PK+F + + WV + W+
Sbjct: 885 YMEENNLEHIPKFFKKVIDANQREAWVSNDTYWE 918
Score = 33.1 bits (74), Expect = 0.99
Identities = 46/205 (22%), Positives = 85/205 (41%), Gaps = 22/205 (10%)
Query: 88 LQGWQNRYFVLDFEAGILQYF-VNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANG 146
L+GW R+FVLD G+L+Y + K G + + +++S+ +A +
Sbjct: 101 LKGWHKRFFVLD--NGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARR--IDLDTEE 156
Query: 147 EMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQR 206
++ L+ WV++LR + + ++ S R S + P + +SP +
Sbjct: 157 HIYHLKVKSQDWFDAWVSKLR---HHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANV 213
Query: 207 HLSVGA------PGVVTITHHKS-PAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAI 259
+ G P + S PA +S+ + L + EM E +L H
Sbjct: 214 SVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAE----DLAHCQ 269
Query: 260 ESLPGSGPLTALDQDLLLLKATSAA 284
+L L+ L Q+L +L+ T +A
Sbjct: 270 SNLV---ELSKLLQNLEILQRTQSA 291
>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
Length = 916
Score = 99.4 bits (246), Expect = 1e-20
Identities = 183/838 (21%), Positives = 318/838 (37%), Gaps = 152/838 (18%)
Query: 12 GGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGG--------GGSRSSPGSVAA 63
G +SS + T A S P G R + L G +P V
Sbjct: 107 GSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPM 166
Query: 64 SPSGGGGRRREP-------ALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQ 116
S G G P + EG L K+TN L+G+Q R+FVL G+L Y+ N+
Sbjct: 167 S--GTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLG--NGLLSYYRNQGEMAH 222
Query: 117 KPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLR-ACAKYHME 175
RG ++LS A + D ++ ++ + L+A+ ++Q W+T L A AK
Sbjct: 223 TCRGTINLSTAHIDTEDSCG---ILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRV 279
Query: 176 MNSKSAPSSRSRSLTLLPHGTPNSASPC--SQRHLSVGAPGVVTITH--HKSPAAARRAK 231
MN+ S S T TP S + ++LS+ + T K AA +R+
Sbjct: 280 MNTHSDDSGDDDEAT-----TPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSL 334
Query: 232 SQYSG---------QLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLL----- 277
++ G +L V E +++A + + L
Sbjct: 335 TELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQE 394
Query: 278 LKATSAATLSCLGECLNLLQQSVHQA-GQPS--QKPGASENILGWHGSKSHSTEQLKNGT 334
+ T+ L + N L+++ H A G+P+ K ++L G S E +
Sbjct: 395 QRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTE--Y 452
Query: 335 LGSLPSASANITWAILPNSAEDEQTSQPEPEPNS-----------GSELVLSEDEKSDNE 383
++ +++ IT ++ + ED + ++ +S G+ LV K ++
Sbjct: 453 FDAMEDSTSFIT--VITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLV----PKGSSK 506
Query: 384 DKEETELGVMEDQRSIILHLISQLK--LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDL 441
K + ++ + L+L S +K +G +L+++ +P E S+L+ + + + L
Sbjct: 507 VKRRVRI---PNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHL 563
Query: 442 L-LAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKP 500
L A+ ++ E+ +C V + + + +A KP+NP++GETF DR+
Sbjct: 564 LDKAVHCTSSVEQ--MCLVAAFSVSSYSTTVHRIA-KPFNPMLGETFEL------DRL-- 612
Query: 501 KRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWT- 559
DD LR + EQVSHHPP + Y + H W+
Sbjct: 613 -----------------DDMG----LRSLCEQVSHHPPSAAHY--------VFSKHGWSL 643
Query: 560 ------KSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVELGGKVS 612
SKF G + + +G L G YV+ ++ +I+ W++ G +
Sbjct: 644 WQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIE 703
Query: 613 INCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFT------ 666
I KT + F ++ + R V + G W+ +E +
Sbjct: 704 IVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSS 763
Query: 667 ----YNNGETKVIDTTTLPVYPKKIRPL-------------------EKQGPMESRNLWR 703
++G+ K + T K PL ++G + + R
Sbjct: 764 PSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLR 823
Query: 704 EVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLW 761
R + G D A +K+ LEEKQR+ R+R P +E + Y PLW
Sbjct: 824 PDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAY-TPLW 880
>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
Length = 842
Score = 95.5 bits (236), Expect = 2e-19
Identities = 88/375 (23%), Positives = 158/375 (42%), Gaps = 56/375 (14%)
Query: 409 LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHE 468
+G DL+KV +P + E + L+ + + + LL + A P ER++ + ++A+
Sbjct: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
Query: 469 GRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRF 528
A KP+NP++GET+ C + P + + RF
Sbjct: 547 TYHRA-GCKPFNPVLGETYEC----------------------------ERPDRGF--RF 575
Query: 529 VAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYV 588
++EQVSHHPPIS C E + + K+KF G S+ + +G + L G+ +
Sbjct: 576 ISEQVSHHPPISA--CHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFE 633
Query: 589 FTLPSAYARSILT-IPWVELGGKVSI-NCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHN 646
+ ++ ++L+ W+E G+V I N + + F ++ VH V V +
Sbjct: 634 WNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVL-S 692
Query: 647 PTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKK--------------IRPLEK 692
+ ++ + G+W+ L G + ++P ++ L++
Sbjct: 693 RSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKR 752
Query: 693 QGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGD 752
P L R RYL G+I AA QKR +E+ QR + E + ++F ++ D
Sbjct: 753 SLPSTDTRL-RPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTD 811
Query: 753 G-----WVYFNPLWK 762
WV N W+
Sbjct: 812 SSGKEWWVTNNTYWR 826
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/182 (28%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 88 LQGWQNRYFVLDFEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANG 146
L+GW RYFVL E GIL Y Q K G + + +++S++ +A + + N
Sbjct: 62 LKGWHKRYFVL--EDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNI 119
Query: 147 EMFKLRAADAKEKQFWVTQLRACAKYH-MEMNSKSAPSSRSRSL--TLLPHGTPNSASPC 203
K+++ D Q WV QLRA H ++M S PS+ R + LP SA P
Sbjct: 120 YHLKIKSQDL--FQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALP- 176
Query: 204 SQRHLSVGAPGVVTITHHKSPAAAR--RAKSQYSGQLHEVREMMNQVEGQQKNLVHAIES 261
+G V+ S R S+ G+L E+ ++ +E +H I S
Sbjct: 177 -----GLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLES-----LHRIPS 226
Query: 262 LP 263
P
Sbjct: 227 AP 228
>gi|21450853 oxysterol-binding protein-like protein 2 isoform 2
[Homo sapiens]
Length = 480
Score = 93.6 bits (231), Expect = 6e-19
Identities = 65/256 (25%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 409 LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHE 468
+G++L+K+ +P E S L+ ++M H L+ + P ER+ + ++A
Sbjct: 84 VGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAV-- 141
Query: 469 GRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRF 528
+ KP+NP++GET+ E RF
Sbjct: 142 ASQWERTGKPFNPLLGETYELIRE------------------------------DLGFRF 171
Query: 529 VAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYV 588
++EQVSHHPPIS F+ E + ++ K KF G SV G L LL+H E Y
Sbjct: 172 ISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYT 231
Query: 589 FTLPSAYARSILTIP-WVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNP 647
+T P+ +++ W+E G V I +TG+ + F +G ++H+V ++
Sbjct: 232 WTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKN 291
Query: 648 TNTIVCKAHGEWNGTL 663
+ +G+W L
Sbjct: 292 KKKLF-MIYGKWTECL 306
Score = 35.8 bits (81), Expect = 0.15
Identities = 15/41 (36%), Positives = 25/41 (60%)
Query: 707 RYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
R + G++D A+++K LEEKQR R+R W+ ++F
Sbjct: 409 RGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWF 449
>gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [Homo
sapiens]
Length = 468
Score = 93.6 bits (231), Expect = 6e-19
Identities = 65/256 (25%), Positives = 110/256 (42%), Gaps = 34/256 (13%)
Query: 409 LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHE 468
+G++L+K+ +P E S L+ ++M H L+ + P ER+ + ++A
Sbjct: 72 VGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVAAFAVSAV-- 129
Query: 469 GRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRF 528
+ KP+NP++GET+ E RF
Sbjct: 130 ASQWERTGKPFNPLLGETYELIRE------------------------------DLGFRF 159
Query: 529 VAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYV 588
++EQVSHHPPIS F+ E + ++ K KF G SV G L LL+H E Y
Sbjct: 160 ISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYT 219
Query: 589 FTLPSAYARSILTIP-WVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNP 647
+T P+ +++ W+E G V I +TG+ + F +G ++H+V ++
Sbjct: 220 WTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKN 279
Query: 648 TNTIVCKAHGEWNGTL 663
+ +G+W L
Sbjct: 280 KKKLF-MIYGKWTECL 294
Score = 35.8 bits (81), Expect = 0.15
Identities = 15/41 (36%), Positives = 25/41 (60%)
Query: 707 RYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYF 747
R + G++D A+++K LEEKQR R+R W+ ++F
Sbjct: 397 RGMENGNMDLASQEKERLEEKQREARRERAKEEAEWQTRWF 437
>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
[Homo sapiens]
Length = 820
Score = 91.7 bits (226), Expect = 2e-18
Identities = 122/587 (20%), Positives = 231/587 (39%), Gaps = 91/587 (15%)
Query: 221 HKSPAA-ARRAKSQYSG--QLHEVREMMNQVE-GQQKNLVHAIESLPGSGPLTALDQDLL 276
+ +PA A + +SG +LH ++ ++ G++KN E+ S + + +DL
Sbjct: 250 YSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSET---SSEFSKMQEDLC 306
Query: 277 LLKATSAATLSCLGECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLG 336
+ TL ++ ++ + Q + S ++G + S + +N L
Sbjct: 307 HIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSENSRDENRALV 366
Query: 337 SLPSASANITWA-------------ILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNE 383
S + ++ + P+S+E+E + + L L D S++
Sbjct: 367 HQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSL--DNLSNDL 424
Query: 384 DKEETELGVMEDQ-------------------RSIILHLISQLKLGMDLTKVVLPTFILE 424
D E LG + D +I L I + +G DL+KV +P + E
Sbjct: 425 DNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNE 484
Query: 425 KRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIG 484
+ L+ + + + +LL +P ER++ + ++A+ A KP+NP++G
Sbjct: 485 PLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRA-GSKPFNPVLG 543
Query: 485 ETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYC 544
ET+ C E K ++ F +EQVSHHPPIS C
Sbjct: 544 ETYECIRE----------------------------DKGFQ--FFSEQVSHHPPISA--C 571
Query: 545 ECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILT-IP 603
E + V K+KF G S+ + IG + L G+ + + ++ +IL+
Sbjct: 572 HAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQR 631
Query: 604 WVELGGKVSI-NCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGT 662
W+E G++ I N V F ++ H + V + + V + G+W+ +
Sbjct: 632 WIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTV-FDRSGKAVHRLFGKWHES 690
Query: 663 LEFTYNNGETKVIDTTTLP-------------VYPKKIRPLEKQGPMESRNLWREVTRYL 709
+ + V +P + ++ P K + +R R+L
Sbjct: 691 IYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFL 750
Query: 710 RLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQ-EGDGWV 755
G+++ A QK+ +E+ QR R E +P++F + + D WV
Sbjct: 751 EEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWV 797
Score = 36.2 bits (82), Expect = 0.12
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 19/156 (12%)
Query: 42 SRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEG--VLSKYTNLLQGWQNRYFVLD 99
SRS ++ GSR V G +EP ++ +L K L+GW R+F LD
Sbjct: 18 SRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLD 77
Query: 100 FEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKE 158
GIL+Y ++ + +K G + + +++S+ + + ++ L+ +
Sbjct: 78 --KGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSS--KCIDLDTEEHIYHLKVKSEEV 133
Query: 159 KQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPH 194
WV++LR Y R + + PH
Sbjct: 134 FDEWVSKLRHHRMY------------RQNEIAMFPH 157
>gi|21735582 oxysterol-binding protein-like protein 3 isoform c
[Homo sapiens]
Length = 851
Score = 91.3 bits (225), Expect = 3e-18
Identities = 117/568 (20%), Positives = 222/568 (39%), Gaps = 88/568 (15%)
Query: 237 QLHEVREMMNQVE-GQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNL 295
+LH ++ ++ G++KN E+ S + + +DL + TL ++
Sbjct: 300 RLHSSNPNLSTLDFGEEKNYSDGSET---SSEFSKMQEDLCHIAHKVYFTLRSAFNIMSA 356
Query: 296 LQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWA------- 348
++ + Q + S ++G + S + +N L S + ++
Sbjct: 357 EREKLKQLMEQDASSSPSAQVIGLKNALSSENSRDENRALVHQLSNESRLSITDSLSEFF 416
Query: 349 ------ILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQ------ 396
+ P+S+E+E + + L L D S++ D E LG + D
Sbjct: 417 DAQEVLLSPSSSENEISDDDSYVSDISDNLSL--DNLSNDLDNERQTLGPVLDSGREAKS 474
Query: 397 -------------RSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLL 443
+I L I + +G DL+KV +P + E + L+ + + + +LL
Sbjct: 475 RRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLD 534
Query: 444 AITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRT 503
+P ER++ + ++A+ A KP+NP++GET+ C E
Sbjct: 535 KAAQIPSPLERMVYVAAFAISAYASSYYRA-GSKPFNPVLGETYECIRE----------- 582
Query: 504 ASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKF 563
K ++ F +EQVSHHPPIS C E + V K+KF
Sbjct: 583 -----------------DKGFQ--FFSEQVSHHPPISA--CHAESRNFVFWQDVRWKNKF 621
Query: 564 MGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILT-IPWVELGGKVSI-NCAKTGYS 621
G S+ + IG + L G+ + + ++ +IL+ W+E G++ I N
Sbjct: 622 WGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCY 681
Query: 622 ATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLP 681
V F ++ H + V + + V + G+W+ ++ + V +P
Sbjct: 682 CKVNFIKAKYWSTNAHEIEGTV-FDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMP 740
Query: 682 -------------VYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQ 728
+ ++ P K + +R R+L G+++ A QK+ +E+ Q
Sbjct: 741 KGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQ 800
Query: 729 RVEERKRENLRTPWKPKYFIQ-EGDGWV 755
R R E +P++F + + D WV
Sbjct: 801 RERRRVLEENHVEHQPRFFRKSDDDSWV 828
Score = 36.2 bits (82), Expect = 0.12
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 19/156 (12%)
Query: 42 SRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEG--VLSKYTNLLQGWQNRYFVLD 99
SRS ++ GSR V G +EP ++ +L K L+GW R+F LD
Sbjct: 18 SRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLD 77
Query: 100 FEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKE 158
GIL+Y ++ + +K G + + +++S+ + + ++ L+ +
Sbjct: 78 --KGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSS--KCIDLDTEEHIYHLKVKSEEV 133
Query: 159 KQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPH 194
WV++LR Y R + + PH
Sbjct: 134 FDEWVSKLRHHRMY------------RQNEIAMFPH 157
>gi|21735580 oxysterol-binding protein-like protein 3 isoform b
[Homo sapiens]
Length = 856
Score = 89.4 bits (220), Expect = 1e-17
Identities = 99/440 (22%), Positives = 177/440 (40%), Gaps = 71/440 (16%)
Query: 351 PNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQ-------------- 396
P+S+E+E + + L L D S++ D E LG + D
Sbjct: 430 PSSSENEISDDDSYVSDISDNLSL--DNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPA 487
Query: 397 -----RSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATP 451
+I L I + +G DL+KV +P + E + L+ + + + +LL +P
Sbjct: 488 PCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSP 547
Query: 452 EERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASC 511
ER++ + ++A+ A KP+NP++GET+ C E
Sbjct: 548 LERMVYVAAFAISAYASSYYRA-GSKPFNPVLGETYECIRE------------------- 587
Query: 512 HEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVS 571
K ++ F +EQVSHHPPIS C E + V K+KF G S+ +
Sbjct: 588 ---------DKGFQ--FFSEQVSHHPPISA--CHAESRNFVFWQDVRWKNKFWGKSMEIV 634
Query: 572 MIGEGVLRLLEHGEEYVFTLPSAYARSILT-IPWVELGGKVSI-NCAKTGYSATVIFHTK 629
IG + L G+ + + ++ +IL+ W+E G++ I N V F
Sbjct: 635 PIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKA 694
Query: 630 PFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLP-------- 681
++ H + V + + V + G+W+ ++ + V +P
Sbjct: 695 KYWSTNAHEIEGTV-FDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYS 753
Query: 682 -----VYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRE 736
+ ++ P K + +R R+L G+++ A QK+ +E+ QR R E
Sbjct: 754 FTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLE 813
Query: 737 NLRTPWKPKYFIQ-EGDGWV 755
+P++F + + D WV
Sbjct: 814 ENHVEHQPRFFRKSDDDSWV 833
Score = 36.2 bits (82), Expect = 0.12
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 19/156 (12%)
Query: 42 SRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEG--VLSKYTNLLQGWQNRYFVLD 99
SRS ++ GSR V G +EP ++ +L K L+GW R+F LD
Sbjct: 18 SRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLD 77
Query: 100 FEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKE 158
GIL+Y ++ + +K G + + +++S+ + + ++ L+ +
Sbjct: 78 --KGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSS--KCIDLDTEEHIYHLKVKSEEV 133
Query: 159 KQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPH 194
WV++LR Y R + + PH
Sbjct: 134 FDEWVSKLRHHRMY------------RQNEIAMFPH 157
>gi|14149704 oxysterol-binding protein-like protein 3 isoform a
[Homo sapiens]
Length = 887
Score = 89.4 bits (220), Expect = 1e-17
Identities = 99/440 (22%), Positives = 177/440 (40%), Gaps = 71/440 (16%)
Query: 351 PNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQ-------------- 396
P+S+E+E + + L L D S++ D E LG + D
Sbjct: 461 PSSSENEISDDDSYVSDISDNLSL--DNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPA 518
Query: 397 -----RSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATP 451
+I L I + +G DL+KV +P + E + L+ + + + +LL +P
Sbjct: 519 PCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSP 578
Query: 452 EERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASC 511
ER++ + ++A+ A KP+NP++GET+ C E
Sbjct: 579 LERMVYVAAFAISAYASSYYRA-GSKPFNPVLGETYECIRE------------------- 618
Query: 512 HEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVS 571
K ++ F +EQVSHHPPIS C E + V K+KF G S+ +
Sbjct: 619 ---------DKGFQ--FFSEQVSHHPPISA--CHAESRNFVFWQDVRWKNKFWGKSMEIV 665
Query: 572 MIGEGVLRLLEHGEEYVFTLPSAYARSILT-IPWVELGGKVSI-NCAKTGYSATVIFHTK 629
IG + L G+ + + ++ +IL+ W+E G++ I N V F
Sbjct: 666 PIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKA 725
Query: 630 PFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLP-------- 681
++ H + V + + V + G+W+ ++ + V +P
Sbjct: 726 KYWSTNAHEIEGTV-FDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYS 784
Query: 682 -----VYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRE 736
+ ++ P K + +R R+L G+++ A QK+ +E+ QR R E
Sbjct: 785 FTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLE 844
Query: 737 NLRTPWKPKYFIQ-EGDGWV 755
+P++F + + D WV
Sbjct: 845 ENHVEHQPRFFRKSDDDSWV 864
Score = 36.2 bits (82), Expect = 0.12
Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 19/156 (12%)
Query: 42 SRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEG--VLSKYTNLLQGWQNRYFVLD 99
SRS ++ GSR V G +EP ++ +L K L+GW R+F LD
Sbjct: 18 SRSTSSCSSKQGSRQDSWEVVEGLRGEMNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLD 77
Query: 100 FEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKE 158
GIL+Y ++ + +K G + + +++S+ + + ++ L+ +
Sbjct: 78 --KGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSS--KCIDLDTEEHIYHLKVKSEEV 133
Query: 159 KQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPH 194
WV++LR Y R + + PH
Sbjct: 134 FDEWVSKLRHHRMY------------RQNEIAMFPH 157
>gi|194294543 alpha 3 type IV collagen binding protein isoform 3
[Homo sapiens]
Length = 752
Score = 63.9 bits (154), Expect = 5e-10
Identities = 58/165 (35%), Positives = 77/165 (46%), Gaps = 17/165 (10%)
Query: 12 GGSNSS----SRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGG---GSRSSPGSVAAS 64
GG SS + RA A SP S G G SS AA G G G G R+S +
Sbjct: 77 GGRTSSLLLLPPTPERALFASPSPDPSPRGLGASS-GAAEGAGAGLLLGCRASMSDNQSW 135
Query: 65 PSGGGGRRRE----PALE--GVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKP 118
S G E P +E GVLSK+TN + GWQ+R+ VL A L Y+ +E
Sbjct: 136 NSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSEDETEYGC 193
Query: 119 RGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWV 163
RG + LS A+++ D + S N ++ LRA D +Q W+
Sbjct: 194 RGSICLSKAVITPHDFDECRFDI-SVNDSVWYLRAQDPDHRQQWI 237
>gi|54792084 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 3 [Homo
sapiens]
Length = 300
Score = 52.4 bits (124), Expect = 2e-06
Identities = 30/96 (31%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 77 LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAP 136
+EGVL K+TN L GWQ R+FVLD GIL Y+ ++ + +G + ++ + +
Sbjct: 1 MEGVLYKWTNYLTGWQPRWFVLD--NGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADN 58
Query: 137 HMLVVYSANGEMFKLRAADAKEKQFWVTQL---RAC 169
+ + + F ++A +A E+Q W+ L +AC
Sbjct: 59 TRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKAC 94
>gi|14165452 alpha 3 type IV collagen binding protein isoform 2
[Homo sapiens]
Length = 598
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/85 (36%), Positives = 46/85 (54%), Gaps = 3/85 (3%)
Query: 79 GVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHM 138
GVLSK+TN + GWQ+R+ VL A L Y+ +E RG + LS A+++ D
Sbjct: 28 GVLSKWTNYIHGWQDRWVVLKNNA--LSYYKSEDETEYGCRGSICLSKAVITPHDFDECR 85
Query: 139 LVVYSANGEMFKLRAADAKEKQFWV 163
+ S N ++ LRA D +Q W+
Sbjct: 86 FDI-SVNDSVWYLRAQDPDHRQQWI 109
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,902,603
Number of Sequences: 37866
Number of extensions: 1571556
Number of successful extensions: 11943
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 9390
Number of HSP's gapped (non-prelim): 1947
length of query: 764
length of database: 18,247,518
effective HSP length: 110
effective length of query: 654
effective length of database: 14,082,258
effective search space: 9209796732
effective search space used: 9209796732
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.