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Search of human proteins with 19923468
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923468 protein kinase D2 isoform A [Homo sapiens]
(878 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 1788 0.0
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 1788 0.0
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 1788 0.0
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 1467 0.0
gi|115529463 protein kinase D1 [Homo sapiens] 1213 0.0
gi|5031689 protein kinase D3 [Homo sapiens] 1117 0.0
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 186 8e-47
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 186 8e-47
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 180 4e-45
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 179 1e-44
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 179 1e-44
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 172 2e-42
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 172 2e-42
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 172 2e-42
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 171 3e-42
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 166 9e-41
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 162 2e-39
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 162 2e-39
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 159 1e-38
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 159 1e-38
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 159 1e-38
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 159 1e-38
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 159 1e-38
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 159 1e-38
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 159 1e-38
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 157 4e-38
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 156 7e-38
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 156 7e-38
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 156 7e-38
gi|27901803 protein serine kinase H1 [Homo sapiens] 156 9e-38
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1788 bits (4631), Expect = 0.0
Identities = 878/878 (100%), Positives = 878/878 (100%)
Query: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL
Sbjct: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
Query: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL
Sbjct: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
Query: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC
Sbjct: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
Query: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS
Sbjct: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
Query: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF
Sbjct: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
Query: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH
Sbjct: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
Query: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR
Sbjct: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
Query: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE
Sbjct: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
Query: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ
Sbjct: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA
Sbjct: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
Query: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV
Sbjct: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
Query: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP
Sbjct: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
Query: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA
Sbjct: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
Query: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF
Sbjct: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
Query: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
Sbjct: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1788 bits (4631), Expect = 0.0
Identities = 878/878 (100%), Positives = 878/878 (100%)
Query: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL
Sbjct: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
Query: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL
Sbjct: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
Query: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC
Sbjct: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
Query: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS
Sbjct: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
Query: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF
Sbjct: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
Query: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH
Sbjct: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
Query: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR
Sbjct: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
Query: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE
Sbjct: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
Query: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ
Sbjct: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA
Sbjct: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
Query: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV
Sbjct: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
Query: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP
Sbjct: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
Query: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA
Sbjct: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
Query: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF
Sbjct: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
Query: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
Sbjct: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1788 bits (4631), Expect = 0.0
Identities = 878/878 (100%), Positives = 878/878 (100%)
Query: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL
Sbjct: 1 MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLL 60
Query: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL
Sbjct: 61 PAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDL 120
Query: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC
Sbjct: 121 VEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRC 180
Query: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS
Sbjct: 181 AFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSS 240
Query: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF
Sbjct: 241 SSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKF 300
Query: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH
Sbjct: 301 NCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADKSALMDESEDSGVIPGSHSENALH 360
Query: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR
Sbjct: 361 ASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWR 420
Query: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE
Sbjct: 421 LDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGE 480
Query: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ
Sbjct: 481 MPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQ 540
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA
Sbjct: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVA 600
Query: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV
Sbjct: 601 ILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
Query: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP
Sbjct: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
Query: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA
Sbjct: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGA 780
Query: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF
Sbjct: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQF 840
Query: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL
Sbjct: 841 AAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISVL 878
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 1467 bits (3797), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 158 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 217
MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC
Sbjct: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
Query: 218 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 277
TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV
Sbjct: 61 TAEELSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTV 120
Query: 278 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 337
CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK
Sbjct: 121 CQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEATDFSEADK 180
Query: 338 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 397
SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST
Sbjct: 181 SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSST 240
Query: 398 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 457
TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL
Sbjct: 241 TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSL 300
Query: 458 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 517
VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP
Sbjct: 301 VPPGTNPHCFEIVTANATYFVGEMPGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAP 360
Query: 518 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 577
SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV
Sbjct: 361 SAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDV 420
Query: 578 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 637
AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM
Sbjct: 421 AVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEM 480
Query: 638 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 697
ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG
Sbjct: 481 ILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFG 540
Query: 698 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 757
FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI
Sbjct: 541 FARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDI 600
Query: 758 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 817
NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR
Sbjct: 601 NDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLR 660
Query: 818 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 877
ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV
Sbjct: 661 ELEGKMGERYITHESDDARWEQFAAEHPLPGSGLPTDRDLGGACPPQDHDMQGLAERISV 720
Query: 878 L 878
L
Sbjct: 721 L 721
Score = 67.8 bits (164), Expect = 4e-11
Identities = 27/53 (50%), Positives = 33/53 (62%)
Query: 138 PHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSG 190
PH +HSY P C C ++L GL RQGL+C C N HKRCA +PN+C G
Sbjct: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 1213 bits (3139), Expect = 0.0
Identities = 626/918 (68%), Positives = 718/918 (78%), Gaps = 65/918 (7%)
Query: 2 ATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLP 61
A A + A +PGS GPG P P L + AP G+SFH+QIGL+RE VLL
Sbjct: 19 AAAAAAAALVPGS-GPG------------PAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
Query: 62 AASE----LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQE 117
S LAHV+++ACSIVDQKFPECGFYG+YDKILLF+HDPTS N+LQLV+++ DIQE
Sbjct: 66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQE 125
Query: 118 GDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYH 177
GDL+EVVLSASATFEDFQIRPHAL VHSYRAPAFCDHCGEML+GLVRQGLKC+GCGLNYH
Sbjct: 126 GDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYH 185
Query: 178 KRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEE--LSRSTTELLPRRPP 235
KRCAF IPNNCSG R+RRLS+ SL ++R ++E +E L +S +E R
Sbjct: 186 KRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREK 245
Query: 236 SSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQC 295
S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRPTVCQ CKKLLKGLFRQGLQC
Sbjct: 246 RSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQC 301
Query: 296 KDCKFNCHKRCATRVPNDCLGEALINGD---------VPMEEATDFSEADK-SALMDESE 345
KDC+FNCHKRCA +VPN+CLGE INGD V MEE +D +++++ S LMD+ E
Sbjct: 302 KDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDME 361
Query: 346 DSGVIPGSHSENALHASEEEEGEGGKAQ---------------SSLGYIPLMRVVQSVRH 390
++ V ++A A E + + G+ Q S+ IPLMRVVQSV+H
Sbjct: 362 EAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKH 415
Query: 391 TTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVE 450
T RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQN+T +RYYKEIPLSEIL++E
Sbjct: 416 TKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLE 475
Query: 451 SAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS--------GQGAEAARGWET 502
+ +L+P G NPHCFEI TAN Y+VGE P PS G GA+ AR WE
Sbjct: 476 PVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPSPNNSVLTSGVGADVARMWEI 534
Query: 503 AIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQF 562
AI+ ALMPVI + + G HR S+SISVSN QIQENVDI+TVYQIFPDEVLGSGQF
Sbjct: 535 AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQF 594
Query: 563 GVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK 622
G+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAILQ+L HPG+VNLECMFETPE+
Sbjct: 595 GIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPER 654
Query: 623 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL 682
VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVALRHLHFKNIVHCDLKPENVLL
Sbjct: 655 VFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL 714
Query: 683 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMY 742
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL N+GYNRSLDMWSVGVI+Y
Sbjct: 715 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIY 774
Query: 743 VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSL 802
VSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVDK+L
Sbjct: 775 VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL 834
Query: 803 SHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL--PGSGLPTDRDLGGA 860
SHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A E L P +
Sbjct: 835 SHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT 894
Query: 861 CPPQDHDMQGLAERISVL 878
++ +M+ L ER+S+L
Sbjct: 895 PETEETEMKALGERVSIL 912
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 1117 bits (2888), Expect = 0.0
Identities = 570/861 (66%), Positives = 661/861 (76%), Gaps = 31/861 (3%)
Query: 8 PAGLPGSPGPGSPPPPGGLELQS---PPPLLPQIPAPGSGVSFHIQIGLTREFVLLPAAS 64
PA LP + SP L + P L VSF +QIGLTRE V + A
Sbjct: 20 PAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQE 79
Query: 65 -ELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQEGDLVEV 123
L+ VK L CSIV QKFPECGF+G+YDKILLF+HD S N+LQL+ S+ +I EGDLVEV
Sbjct: 80 LSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV 139
Query: 124 VLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFS 183
VLSA AT EDFQIRPH L VHSY+AP FCD+CGEML+GLVRQGLKC+GCGLNYHKRCAF
Sbjct: 140 VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFK 199
Query: 184 IPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEELSRSTTELLPRRPPSSSSSSSA 243
IPNNCSG RKRRLS+ SL G S P E ++ + E + PS
Sbjct: 200 IPNNCSGVRKRRLSNVSLPGP-----GLSVPRPLQPEYVALPSEESHVHQEPSKR----I 250
Query: 244 SSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCH 303
S++GRPI ++KM++ +VKVPHTF +HSYTRPT+CQ CK+LLKGLFRQG+QCKDCKFNCH
Sbjct: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
Query: 304 KRCATRVPNDCLGEALING---------DVPMEEATDFSEADKSALMDESEDSGVIPGSH 354
KRCA++VP DCLGE NG D+PM+ + +D S +D++E+
Sbjct: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKM 370
Query: 355 ---SENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKD 411
+ L +EE + S+ IPLMRVVQS++HT RKSST ++EGW+VHY+++D
Sbjct: 371 FFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRD 430
Query: 412 TLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVT 471
LRKRHYWRLD KC+TLFQN + ++YYKEIPLSEIL + S ++F+ + G+NPHCFEI+T
Sbjct: 431 NLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIIT 490
Query: 472 ANATYFVGEMPGGTPGGP----SGQGAEAARGWETAIRQALMPVILQDAP-SAPGHAP-H 525
YFVGE G + P +G G + A+ WE AIRQALMPV Q + ++PG H
Sbjct: 491 DTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDH 550
Query: 526 RQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKL 585
+ S SISVSN QIQENVDI+TVYQIF DEVLGSGQFG+VYGGKHRKTGRDVA+KVIDK+
Sbjct: 551 KDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKM 610
Query: 586 RFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGR 645
RFPTKQESQLRNEVAILQ+L HPGIVNLECMFETPE+VFVVMEKLHGDMLEMILSSEK R
Sbjct: 611 RFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSR 670
Query: 646 LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK 705
LPER+TKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKLCDFGFARIIGEK
Sbjct: 671 LPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEK 730
Query: 706 SFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAA 765
SFRRSVVGTPAYLAPEVL ++GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDINDQIQNAA
Sbjct: 731 SFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAA 790
Query: 766 FMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGE 825
FMYP +PW IS AIDLINNLLQVKMRKRYSVDKSLSHPWLQ+YQTWLDLRE E ++GE
Sbjct: 791 FMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGE 850
Query: 826 RYITHESDDARWEQFAAEHPL 846
RYITHESDDARWE A H L
Sbjct: 851 RYITHESDDARWEIHAYTHNL 871
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 186 bits (472), Expect = 8e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 227 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 286
Query: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 287 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 345
Query: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 346 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 403
Query: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 404 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 463
Query: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 464 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 523
Query: 802 LSHPWLQE 809
L HPWLQ+
Sbjct: 524 LRHPWLQD 531
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 186 bits (472), Expect = 8e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
Query: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
Query: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
Query: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
Query: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
Query: 802 LSHPWLQE 809
L HPWLQ+
Sbjct: 481 LRHPWLQD 488
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 180 bits (457), Expect = 4e-45
Identities = 104/259 (40%), Positives = 154/259 (59%), Gaps = 11/259 (4%)
Query: 556 VLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLEC 615
V+G G F VV +HR+T + A+K+IDK R K E + +E+ I+QSL HP IV L
Sbjct: 361 VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGK-EDMVDSEILIIQSLSHPNIVKLHE 419
Query: 616 MFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCD 674
++ET ++++++E + G D+ + I+ S K PE +I + AL H+H K+IVH D
Sbjct: 420 VYETDMEIYLILEYVQGGDLFDAIIESVK--FPEPDAALMIMDLCKALVHMHDKSIVHRD 477
Query: 675 LKPENVLLA-SADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLD 733
LKPEN+L+ + D +KL DFG A+ + F +V GTP Y+APE+L +GY +D
Sbjct: 478 LKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEILSEKGYGLEVD 535
Query: 734 MWSVGVIMYVSLSGTFPFNEDEDINDQ----IQNAAFMYPASPWSHISAGAIDLINNLLQ 789
MW+ GVI+Y+ L G PF E D+ IQ F + W +IS A DL++ LL
Sbjct: 536 MWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLV 595
Query: 790 VKMRKRYSVDKSLSHPWLQ 808
V +KRY+ + L HPW++
Sbjct: 596 VDPKKRYTAHQVLQHPWIE 614
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 179 bits (454), Expect = 1e-44
Identities = 101/276 (36%), Positives = 164/276 (59%), Gaps = 8/276 (2%)
Query: 535 SNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ 594
S+S ++ DI +++ E LG+G F V + + TG+ AVK I K K ES
Sbjct: 9 SSSWKKQAEDIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESS 65
Query: 595 LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKF 653
+ NE+A+L+ ++H IV LE ++E+P +++VM+ + G ++ + I+ EKG E+
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDAST 123
Query: 654 LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG 713
LI Q+L A+ +LH IVH DLKPEN+L S D ++ + DFG +++ G+ + G
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 183
Query: 714 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPAS 771
TP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + +
Sbjct: 184 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 243
Query: 772 PWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 807
W IS A D I NL++ KRY+ +++ HPW+
Sbjct: 244 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 179 bits (454), Expect = 1e-44
Identities = 101/276 (36%), Positives = 164/276 (59%), Gaps = 8/276 (2%)
Query: 535 SNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ 594
S+S ++ DI +++ E LG+G F V + + TG+ AVK I K K ES
Sbjct: 9 SSSWKKQAEDIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESS 65
Query: 595 LRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKF 653
+ NE+A+L+ ++H IV LE ++E+P +++VM+ + G ++ + I+ EKG E+
Sbjct: 66 IENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDAST 123
Query: 654 LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG 713
LI Q+L A+ +LH IVH DLKPEN+L S D ++ + DFG +++ G+ + G
Sbjct: 124 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 183
Query: 714 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPAS 771
TP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + +
Sbjct: 184 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 243
Query: 772 PWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 807
W IS A D I NL++ KRY+ +++ HPW+
Sbjct: 244 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 172 bits (435), Expect = 2e-42
Identities = 106/282 (37%), Positives = 163/282 (57%), Gaps = 13/282 (4%)
Query: 534 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 593
V+ ++ E+ + Y+I +V+G G F VV R TG++ A+K+IDK + K E
Sbjct: 378 VNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EH 434
Query: 594 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 652
+ NEV+IL+ ++HP I+ L ET ++F+VME + G D+ + I SS K ER
Sbjct: 435 LIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGS 492
Query: 653 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 711
++ + ALR+LH +IVH D+KPEN+L+ D +KL DFG A ++ + +V
Sbjct: 493 AMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TV 550
Query: 712 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 767
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF N ED+ DQI
Sbjct: 551 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLE 610
Query: 768 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
+PA W +I+ A +LI+ +LQV + R + + LSHPW+ +
Sbjct: 611 FPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 652
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 172 bits (435), Expect = 2e-42
Identities = 106/282 (37%), Positives = 163/282 (57%), Gaps = 13/282 (4%)
Query: 534 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 593
V+ ++ E+ + Y+I +V+G G F VV R TG++ A+K+IDK + K E
Sbjct: 379 VNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGK-EH 435
Query: 594 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 652
+ NEV+IL+ ++HP I+ L ET ++F+VME + G D+ + I SS K ER
Sbjct: 436 LIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTK--YTERDGS 493
Query: 653 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 711
++ + ALR+LH +IVH D+KPEN+L+ D +KL DFG A ++ + +V
Sbjct: 494 AMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLY--TV 551
Query: 712 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 767
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF N ED+ DQI
Sbjct: 552 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLE 611
Query: 768 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
+PA W +I+ A +LI+ +LQV + R + + LSHPW+ +
Sbjct: 612 FPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 653
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 172 bits (435), Expect = 2e-42
Identities = 95/256 (37%), Positives = 157/256 (61%), Gaps = 8/256 (3%)
Query: 555 EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLE 614
EVLGSG F V+ K R TG+ A+K I K P ++S L NE+A+L+ ++H IV LE
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKS--PAFRDSSLENEIAVLKKIKHENIVTLE 84
Query: 615 CMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHC 673
++E+ ++VM+ + G ++ + IL E+G E+ +I Q+L A+++LH IVH
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRIL--ERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142
Query: 674 DLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLD 733
DLKPEN+L + + ++ + DFG +++ + + GTP Y+APEVL + Y++++D
Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKPYSKAVD 201
Query: 734 MWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLINNLLQVK 791
WS+GVI Y+ L G PF E+ + + ++I+ + + + W IS A D I +LL+
Sbjct: 202 CWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD 261
Query: 792 MRKRYSVDKSLSHPWL 807
+RY+ +K+LSHPW+
Sbjct: 262 PNERYTCEKALSHPWI 277
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 171 bits (433), Expect = 3e-42
Identities = 97/278 (34%), Positives = 164/278 (58%), Gaps = 8/278 (2%)
Query: 533 SVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQE 592
+V + ++ DI +Y +VLG+G F V + ++T + VA+K I K K E
Sbjct: 4 AVEGPRWKQAEDIRDIYDF--RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGK-E 60
Query: 593 SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLT 651
+ NE+A+L ++HP IV L+ ++E+ ++++M+ + G ++ + I+ EKG ER
Sbjct: 61 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIV--EKGFYTERDA 118
Query: 652 KFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSV 711
LI Q+L A+++LH IVH DLKPEN+L S D ++ + DFG +++ S +
Sbjct: 119 SRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTA 178
Query: 712 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYP 769
GTP Y+APEVL + Y++++D WS+GVI Y+ L G PF ++ D + +QI A + +
Sbjct: 179 CGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFD 238
Query: 770 ASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWL 807
+ W IS A D I +L++ KR++ +++L HPW+
Sbjct: 239 SPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 166 bits (420), Expect = 9e-41
Identities = 93/255 (36%), Positives = 147/255 (57%), Gaps = 10/255 (3%)
Query: 557 LGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECM 616
LG G +VY K + T + A+KV+ K T + +R E+ +L L HP I+ L+ +
Sbjct: 52 LGRGATSIVYRCKQKGTQKPYALKVLKK----TVDKKIVRTEIGVLLRLSHPNIIKLKEI 107
Query: 617 FETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDL 675
FETP ++ +V+E + G ++ + I+ EKG ER + QIL A+ +LH IVH DL
Sbjct: 108 FETPTEISLVLELVTGGELFDRIV--EKGYYSERDAADAVKQILEAVAYLHENGIVHRDL 165
Query: 676 KPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMW 735
KPEN+L A+ P +K+ DFG ++I+ + ++V GTP Y APE+L Y +DMW
Sbjct: 166 KPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMW 225
Query: 736 SVGVIMYVSLSGTFPFNE---DEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKM 792
SVG+I Y+ L G PF + D+ + +I N + + + W +S A DL+ L+ +
Sbjct: 226 SVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDP 285
Query: 793 RKRYSVDKSLSHPWL 807
+KR + ++L HPW+
Sbjct: 286 KKRLTTFQALQHPWV 300
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 162 bits (409), Expect = 2e-39
Identities = 114/348 (32%), Positives = 184/348 (52%), Gaps = 27/348 (7%)
Query: 482 PGGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQE 541
PG P GP Q EAAR G P R ++++ +
Sbjct: 47 PGAGPAGP--QLREAARA--------------SSGLGGGGRHPSRIPAIALQDMLLLKKH 90
Query: 542 NVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAI 601
DI++VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+
Sbjct: 91 TEDISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAV 147
Query: 602 LQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILV 660
L+ + HP IV LE + E+P +++ ME + G ++ + I+ E+G E+ L+ Q+L
Sbjct: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLG 205
Query: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
A+ +LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+AP
Sbjct: 206 AVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAP 264
Query: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISA 778
E+L + Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + + W IS
Sbjct: 265 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324
Query: 779 GAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGER 826
A D I +LL+ +KR++ ++L H W+ T D R++ G + E+
Sbjct: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWISG-DTAFD-RDILGSVSEQ 370
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 162 bits (409), Expect = 2e-39
Identities = 100/331 (30%), Positives = 164/331 (49%), Gaps = 22/331 (6%)
Query: 483 GGTPGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQEN 542
G +PG SG G A RG R P P A + V Q+
Sbjct: 11 GSSPGATSGSG-RAGRGLSGPCR-----------PPPPPQARGLLTEIRAVVRTEPFQDG 58
Query: 543 VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAIL 602
Y + P LG G+F VV + +G++ A K + K R ++ +E+A+L
Sbjct: 59 ------YSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVL 112
Query: 603 QSLR-HPGIVNLECMFETPEKVFVVME-KLHGDMLEMILSSEKGRLPERLTKFLITQILV 660
+ + +P ++NL ++ET ++ +V+E G++ + ++ + E+ + L+ QIL
Sbjct: 113 ELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILE 172
Query: 661 ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAP 720
+ LH +++VH DLKP+N+LL S P +K+ DFG +RI+ R ++GTP Y+AP
Sbjct: 173 GVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAP 232
Query: 721 EVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF--NEDEDINDQIQNAAFMYPASPWSHISA 778
E+L + + DMWS+GV+ YV L+G PF N+ ++ I Y + +S
Sbjct: 233 EILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSE 292
Query: 779 GAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
A+D I LL K R + ++ L HPWL +
Sbjct: 293 SAVDFIRTLLVKKPEDRATAEECLKHPWLTQ 323
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 159 bits (402), Expect = 1e-38
Identities = 96/268 (35%), Positives = 143/268 (53%), Gaps = 8/268 (2%)
Query: 549 YQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHP 608
YQ+F E LG G F VV TG++ A K+I+ + + +L E I + L+HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 609 GIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHF 667
IV L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 668 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLLNQ 726
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVL
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 727 GYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGAIDLI 784
Y + +DMW+ GVI+Y+ L G PF +++ + QI+ A+ +P+ W ++ A DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 785 NNLLQVKMRKRYSVDKSLSHPWLQEYQT 812
N +L + KR + ++L HPW+ + T
Sbjct: 250 NKMLTINPAKRITASEALKHPWICQRST 277
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 159 bits (401), Expect = 1e-38
Identities = 101/286 (35%), Positives = 166/286 (58%), Gaps = 11/286 (3%)
Query: 544 DIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQ 603
DI++VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+L+
Sbjct: 27 DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLR 83
Query: 604 SLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTKFLITQILVAL 662
+ HP IV LE + E+P +++ ME + G ++ + I+ E+G E+ L+ Q+L A+
Sbjct: 84 RISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAV 141
Query: 663 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 722
+LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+APE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPEL 200
Query: 723 LLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDED--INDQIQNAAFMYPASPWSHISAGA 780
L + Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + + W IS A
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
Query: 781 IDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGER 826
D I +LL+ +KR++ ++L H W+ T D R++ G + E+
Sbjct: 261 KDFIRHLLERDPQKRFTCQQALRHLWISG-DTAFD-RDILGSVSEQ 304
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 157 bits (397), Expect = 4e-38
Identities = 99/282 (35%), Positives = 156/282 (55%), Gaps = 13/282 (4%)
Query: 534 VSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQES 593
VS Q I Y++ +G G F VV R T R+ A+K+I K + K E
Sbjct: 375 VSEEGFQIPATITERYKV--GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGK-EH 431
Query: 594 QLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG-DMLEMILSSEKGRLPERLTK 652
++NEV+IL+ ++HP IV L + P ++++VME + G D+ + I S+ K ER
Sbjct: 432 MIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNK--YTERDAS 489
Query: 653 FLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFARIIGEKSFRRSV 711
++ + A+++LH NIVH D+KPEN+L+ D +KL DFG A I+ + +V
Sbjct: 490 GMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY--TV 547
Query: 712 VGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF----NEDEDINDQIQNAAFM 767
GTP Y+APE++ GY +D+W+ GVI Y+ L G PF ++ E + DQI
Sbjct: 548 CGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD 607
Query: 768 YPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
+P+ W ++S A +LI +L V + +R+S + L HPW+ +
Sbjct: 608 FPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 649
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 156 bits (395), Expect = 7e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 597
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 598 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 654
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 655 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 713
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 714 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 772
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 773 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 156 bits (395), Expect = 7e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 597
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 598 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 654
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 655 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 713
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 714 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 772
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 773 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 156 bits (395), Expect = 7e-38
Identities = 99/277 (35%), Positives = 153/277 (55%), Gaps = 10/277 (3%)
Query: 541 ENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRF---PTKQESQLRN 597
++V VY++ EV+G G F VV +R+TG+ AVK++D +F P L+
Sbjct: 4 DDVLFEDVYELC--EVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKR 61
Query: 598 EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDML--EMILSSEKGRL-PERLTKFL 654
E +I L+HP IV L + + +++V E + G L E++ ++ G + E +
Sbjct: 62 EASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHY 121
Query: 655 ITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSF-RRSVVG 713
+ QIL ALR+ H NI+H D+KP VLLAS + VKL FG A +GE VG
Sbjct: 122 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG 181
Query: 714 TPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPF-NEDEDINDQIQNAAFMYPASP 772
TP ++APEV+ + Y + +D+W GVI+++ LSG PF E + + I +
Sbjct: 182 TPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQ 241
Query: 773 WSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQE 809
WSHIS A DL+ +L + +R +V ++L+HPWL+E
Sbjct: 242 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 156 bits (394), Expect = 9e-38
Identities = 100/322 (31%), Positives = 164/322 (50%), Gaps = 12/322 (3%)
Query: 517 PSAPGHA-PHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGR 575
P GH P + V+ + + + + Y I ++G G F V +HR T +
Sbjct: 65 PPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDI--KALIGRGSFSRVVRVEHRATRQ 122
Query: 576 DVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVME-KLHGDM 634
A+K+I+ ++ + +E+ +L+ +RH I+ L +FET E+V++VME G++
Sbjct: 123 PYAIKMIETKYREGREVCE--SELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL 180
Query: 635 LEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLC 694
+ I++ KG ER ++ +L +R+LH I H DLKPEN+L ++ +
Sbjct: 181 FDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIIT 238
Query: 695 DFGFA--RIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFN 752
DFG A R G+ ++ GTP Y+APEVL+ + Y S+DMW++GVI Y+ LSGT PF
Sbjct: 239 DFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFE 298
Query: 753 EDE--DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEY 810
+D + QI + Y PW +S A D I+ LL V R + ++L HPW+
Sbjct: 299 DDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSM 358
Query: 811 QTWLDLRELEGKMGERYITHES 832
++ L + + + S
Sbjct: 359 AASSSMKNLHRSISQNLLKRAS 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,038,595
Number of Sequences: 37866
Number of extensions: 2002407
Number of successful extensions: 23047
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 763
Number of HSP's successfully gapped in prelim test: 460
Number of HSP's that attempted gapping in prelim test: 14200
Number of HSP's gapped (non-prelim): 6869
length of query: 878
length of database: 18,247,518
effective HSP length: 111
effective length of query: 767
effective length of database: 14,044,392
effective search space: 10772048664
effective search space used: 10772048664
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.