Search of human proteins with 19923122

Search of human proteins with 19923122

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo
sapiens]
         (505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]  1025   0.0  
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    660   0.0  
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   549   e-156
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   488   e-138
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     447   e-125
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   446   e-125
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   444   e-125
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   432   e-121
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   416   e-116
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   393   e-109
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   358   8e-99
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   343   2e-94
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   339   4e-93
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   316   4e-86
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   305   8e-83
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   301   9e-82
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   278   1e-74
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              249   3e-66
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   202   8e-52
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   198   8e-51
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              191   1e-48
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   186   3e-47
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   159   7e-39
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   154   2e-37
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   147   3e-35
gi|4504023 glycine receptor, beta [Homo sapiens]                       89   7e-18
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    83   5e-16
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...    83   5e-16
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...    80   6e-15
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...    79   1e-14

>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score = 1025 bits (2650), Expect = 0.0
 Identities = 505/505 (100%), Positives = 505/505 (100%)

Query: 1   MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV 60
           MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
Sbjct: 1   MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV 60

Query: 61  IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD 120
           IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
Sbjct: 61  IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD 120

Query: 121 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW 180
           IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
Sbjct: 121 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW 180

Query: 181 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL 240
           SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
Sbjct: 181 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL 240

Query: 241 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV 300
           PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
Sbjct: 241 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV 300

Query: 301 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT 360
           IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
Sbjct: 301 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT 360

Query: 361 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT 420
           SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
Sbjct: 361 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT 420

Query: 421 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL 480
           RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL
Sbjct: 421 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL 480

Query: 481 WVFTLVCILGTAGLFLQPLMAREDA 505
           WVFTLVCILGTAGLFLQPLMAREDA
Sbjct: 481 WVFTLVCILGTAGLFLQPLMAREDA 505


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  660 bits (1703), Expect = 0.0
 Identities = 320/471 (67%), Positives = 375/471 (79%), Gaps = 21/471 (4%)

Query: 35  EHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDY 94
           E RLF +LF  YN+ IRPV NVSDPV +HFEV+++QL  VDEVNQIMETNLWL+ IWNDY
Sbjct: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93

Query: 95  KLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAI 154
           KL+W+P +Y G E +RVPA KIWKPDIVLYNNAVGDFQV+ KTKALLKY G +TW PPAI
Sbjct: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153

Query: 155 FKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPG 214
           FKSSC +D+T+FPFD+QNC++KFGSW+YDKA+IDL++IGS +++ D+WE+ EW II A G
Sbjct: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213

Query: 215 YKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVT 274
           YKHDIKYNCCEEIY DITYS YIRRLP+FYTINLIIPCL ISFLTVLVFYLPSDCGEKVT
Sbjct: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273

Query: 275 LCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT 334
           LCISVLLSLTVFLLVITETIPSTSLV+PL+GEYLLFTMIFVTLSIV+TVFVLN+HYRTPT
Sbjct: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333

Query: 335 THTMPSWVKTVFLNLLPRVMFMTRP---TSNEGNAQKPRPLYGAELSNLNCFSRAESKG- 390
           THTMP WVKTVFL LLP+V+ M  P   T   G+   PR L           +R  +KG 
Sbjct: 334 THTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGL-----------ARRPAKGK 382

Query: 391 -CKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVK 449
               G P     C +CH      SN  A   R  S + +  V+  S  SPE+++ I SV+
Sbjct: 383 LASHGEPRHLKECFHCHK-----SNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQ 437

Query: 450 YIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLM 500
           +IAENMK+ NE KE++DDWKYVAMV+DR+FLWVF +VC+ GTAGLFLQPL+
Sbjct: 438 FIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  549 bits (1414), Expect = e-156
 Identities = 280/483 (57%), Positives = 345/483 (71%), Gaps = 25/483 (5%)

Query: 32  SEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIW 91
           +E E RLF+ LF  YN   RPV N SD VI+ F +S++QL+ VDE NQ+M TN+WLKQ W
Sbjct: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEW 115

Query: 92  NDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIP 151
           +DYKL+WNP+D+G    +RVP++ IW PDIVLYNNA G+F V   TKA L  TG V W+P
Sbjct: 116 SDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVP 175

Query: 152 PAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIK 211
           PAI+KSSC IDVT+FPFD QNC MKFGSW+YDKAKIDL  +  +++LKDYWESGEWAI+ 
Sbjct: 176 PAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVN 235

Query: 212 APGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGE 271
           A G  +  KY+CC EIYPD+TY+  IRRLPLFYTINLIIPCLLIS LTVLVFYLPSDCGE
Sbjct: 236 ATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGE 295

Query: 272 KVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYR 331
           K+TLCISVLLSLTVFLL+ITE IPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH+R
Sbjct: 296 KITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 355

Query: 332 TPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ----KPRPLYGAELSNLNCFSR-- 385
           +P+THTMP WV+   L  +PR + M RP            K  P Y    SN++   R  
Sbjct: 356 SPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREV 415

Query: 386 ---AESKGCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLS--ALS 438
               E +    G+  P    +C + H            L   +S    +A+L      LS
Sbjct: 416 VVEEEDRWACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLS 463

Query: 439 PEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQP 498
           P +++A++ V YIA+++++++    +++DWKYVAMVIDRIFLW+F +VC LGT GLFL P
Sbjct: 464 PHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523

Query: 499 LMA 501
            +A
Sbjct: 524 FLA 526


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  488 bits (1257), Expect = e-138
 Identities = 238/360 (66%), Positives = 289/360 (80%), Gaps = 3/360 (0%)

Query: 12  LSPPRLLLL---LLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSM 68
           L PP LLLL   LL +   V   + AE RL ++LF  YN+  RPVAN+SD V++ F +S+
Sbjct: 11  LLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 69  SQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAV 128
           +QL+ VDE NQ+M TN+W+KQ W+DYKL+W+P+DY     +R+P++ IW+PDIVLYNNA 
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130

Query: 129 GDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKID 188
           GDF V   TKA L + G V W PPAI+KSSC IDVT+FPFD QNCTMKFGSW+YDKAKID
Sbjct: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190

Query: 189 LVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINL 248
           LV + S ++  D+WESGEW I+ A G  +  KY CC EIYPDITY+  IRRLPLFYTINL
Sbjct: 191 LVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINL 250

Query: 249 IIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL 308
           IIPCLLIS LTVLVFYLPS+CGEK+TLCISVLLSLTVFLL+ITE IPSTSLVIPLIGEYL
Sbjct: 251 IIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYL 310

Query: 309 LFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQK 368
           LFTMIFVTLSIVITVFVLNVH+R+P THTMP+WV+ VFL+++PR++ M RP+  + N ++
Sbjct: 311 LFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRR 370



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 37/65 (56%), Positives = 53/65 (81%)

Query: 437 LSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496
           LSP +  A++ V+YIA+++KA++    +++DWKYVAMVIDRIFLW+F +VC+LGT GLFL
Sbjct: 560 LSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619

Query: 497 QPLMA 501
            P +A
Sbjct: 620 PPWLA 624


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  447 bits (1150), Expect = e-125
 Identities = 229/489 (46%), Positives = 317/489 (64%), Gaps = 15/489 (3%)

Query: 15  PRLLLLLLLSLLPVA--RASEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEVSMSQ 70
           P L+L  L++L      R + AE +L + L     YN +IRP  + S  + I  ++S++Q
Sbjct: 5   PSLVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQ 64

Query: 71  LVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGD 130
           L+ V+E  QIM TN+WLKQ W DY+L WN S Y G   +R+PA++IW PDIVLYNNA G 
Sbjct: 65  LISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGT 124

Query: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190
           ++V   T  +++  G V W+PPAI+KS+CKI+V YFPFD QNCT+KF SW+YD  +ID+V
Sbjct: 125 YEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMV 184

Query: 191 LIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII 250
           L+  + ++ D+  SGEW I+  PG +     N  +  Y D+TY   I+R PLFYTINLII
Sbjct: 185 LMTPTASMDDFTPSGEWDIVALPGRR---TVNPQDPSYVDVTYDFIIKRKPLFYTINLII 241

Query: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310
           PC+L + L +LVFYLPSDCGEK+TLCISVLL+LT FLL+I++ +P TSL +PLIG+YL+F
Sbjct: 242 PCVLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMF 301

Query: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR 370
           TM+ VT SIV +V VLNVH+R+P+THTM  WVK  FL+ LP  +FM RP  +   A+   
Sbjct: 302 TMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFP 361

Query: 371 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA 430
           P       + +C ++ E+           G   Y  +     S   A  T  +       
Sbjct: 362 P-------SKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDF-W 413

Query: 431 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG 490
           + S      +++EA++ V +IA++MK  +E + + +DWKYVAMV+DR+FLWVF  VC+LG
Sbjct: 414 LRSSGRFRQDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLG 473

Query: 491 TAGLFLQPL 499
           T GLFL PL
Sbjct: 474 TVGLFLPPL 482


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  446 bits (1146), Expect = e-125
 Identities = 233/485 (48%), Positives = 313/485 (64%), Gaps = 40/485 (8%)

Query: 12  LSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQL 71
           + P  LLLL  L    +   SE E RL  +LF+DY+ ++RPV +    V +   + + QL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 72  VKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDF 131
           + VDEVNQI+ TN+ LKQ W DY LKWNP DYGG + + +P++KIW+PD+VLYNNA GDF
Sbjct: 61  INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF 120

Query: 132 QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL 191
            +   TK LL+YTG +TW PPAIFKS C+I VT+FPFD QNC+MK G+W+YD + + +  
Sbjct: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP 180

Query: 192 IGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLII 250
                +L ++ ESGEW I ++ G+KH + Y+CC +  Y DITY   ++RLPL++ +N+II
Sbjct: 181 ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII 240

Query: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310
           PCLL SFLT LVFYLP+D GEK+TL ISVLLSLTVFLLVI E IPSTS  +PLIG+Y+LF
Sbjct: 241 PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF 300

Query: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR 370
           TM+FV  SI+ITV V+N H+R+P+TH MP+WV+ VF++ +P +MF +  T    + +K  
Sbjct: 301 TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS--TMKRPSREKQD 358

Query: 371 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA 430
                E  +++  S       K G P      G+ H   IK                   
Sbjct: 359 KKIFTEDIDISDISG------KPGPP----PMGF-HSPLIK------------------- 388

Query: 431 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG 490
                   PE+K AI+ +KYIAE MK+  E+     +WKYVAMV+D I L VF LVCI+G
Sbjct: 389 -------HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIG 441

Query: 491 TAGLF 495
           T  +F
Sbjct: 442 TLAVF 446


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  444 bits (1142), Expect = e-125
 Identities = 232/498 (46%), Positives = 319/498 (64%), Gaps = 29/498 (5%)

Query: 9   PLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEV 66
           P+AL    LL   LL L      ++ E RL E L +   YN++IRP  N S+ V +   V
Sbjct: 7   PVAL----LLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMV 62

Query: 67  SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNN 126
           S++QL+ V E  QIM TN+WL Q W DY+L W P ++   + +R+P++ IW PD+VLYNN
Sbjct: 63  SLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNN 122

Query: 127 AVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK 186
           A G ++V   + A++ Y G + W+PPAI+KS+CKI+V +FPFD QNCTMKF SW+YD+ +
Sbjct: 123 ADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTE 182

Query: 187 IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTI 246
           IDLVL     +L D+  SGEW I+  PG +++   N  +  Y DITY   IRR PLFYTI
Sbjct: 183 IDLVLKSEVASLDDFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTI 239

Query: 247 NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE 306
           NLIIPC+LI+ L +LVFYLPSDCGEK+TLCISVLL+LTVFLL+I++ +P TSL +PL+G+
Sbjct: 240 NLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGK 299

Query: 307 YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGN- 365
           YL+FTM+ VT SIV +V VLNVH+R+PTTHTM  WVK VFL  LP ++FM +P  +    
Sbjct: 300 YLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQ 359

Query: 366 ----AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTR 421
                ++ R   GA          A+S  C        G+ G        ++        
Sbjct: 360 RLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAG------P 413

Query: 422 SSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLW 481
             S E     L         +EA+  V++IA++M+++++ + + +DWKYVAMVIDR+FLW
Sbjct: 414 GRSGEPCGCGL---------REAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLW 464

Query: 482 VFTLVCILGTAGLFLQPL 499
           +F  VC+ GT G+FLQPL
Sbjct: 465 IFVFVCVFGTIGMFLQPL 482


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  432 bits (1110), Expect = e-121
 Identities = 233/510 (45%), Positives = 313/510 (61%), Gaps = 65/510 (12%)

Query: 12  LSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQL 71
           + P  LLLL  L    +   SE E RL  +LF+DY+ ++RPV +    V +   + + QL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 72  VKVDEVNQIMETNLWLKQ-------------------------IWNDYKLKWNPSDYGGA 106
           + VDEVNQI+ TN+ LKQ                          W DY LKWNP DYGG 
Sbjct: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120

Query: 107 EFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF 166
           + + +P++KIW+PD+VLYNNA GDF +   TK LL+YTG +TW PPAIFKS C+I VT+F
Sbjct: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180

Query: 167 PFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEE 226
           PFD QNC+MK G+W+YD + + +       +L ++ ESGEW I ++ G+KH + Y+CC +
Sbjct: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240

Query: 227 I-YPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTV 285
             Y DITY   ++RLPL++ +N+IIPCLL SFLT LVFYLP+D GEK+TL ISVLLSLTV
Sbjct: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300

Query: 286 FLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTV 345
           FLLVI E IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N H+R+P+TH MP+WV+ V
Sbjct: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360

Query: 346 FLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYC 405
           F++ +P +MF +  T    + +K       E  +++  S       K G P      G+ 
Sbjct: 361 FIDTIPNIMFFS--TMKRPSREKQDKKIFTEDIDISDISG------KPGPP----PMGF- 407

Query: 406 HHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQ 465
           H   IK                           PE+K AI+ +KYIAE MK+  E+    
Sbjct: 408 HSPLIK--------------------------HPEVKSAIEGIKYIAETMKSDQESNNAA 441

Query: 466 DDWKYVAMVIDRIFLWVFTLVCILGTAGLF 495
            +WKYVAMV+D I L VF LVCI+GT  +F
Sbjct: 442 AEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  416 bits (1069), Expect = e-116
 Identities = 221/492 (44%), Positives = 308/492 (62%), Gaps = 50/492 (10%)

Query: 14  PPRLLLLLLLSLLPVARA-----SEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSM 68
           P  +L+L++L +   A       +E E  L   LF+ Y + +RPV + +D + ++F + +
Sbjct: 3   PDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKI 62

Query: 69  SQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAV 128
           SQLV VDE NQ+M TN+WLKQ W D+KL+WNP DYGG   ++VP++ +W PDIVL+ NA 
Sbjct: 63  SQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENAD 122

Query: 129 GDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKID 188
           G F+    TK ++K  G V W PPA +KSSC +DVT+FPFD QNC+MKFGSW+YD   +D
Sbjct: 123 GRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVD 182

Query: 189 LVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINL 248
           L+LI  +++ KD++++GEW I+ A G K + +       YP ITYS  +RRLPLFYT+ L
Sbjct: 183 LILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFL 240

Query: 249 IIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL 308
           IIPCL +SFLTVLVFYLPSD GEK++L  SVL+SLTVFLLVI E IPS+S VIPLIGEYL
Sbjct: 241 IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL 300

Query: 309 LFTMIFVTLSIVITVFVLNVHYRTPTT-HTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ 367
           LF MIFVTLSI++TVFV+NVH+R+ +T H M  WVK +FL  LP+++ M        + +
Sbjct: 301 LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE 360

Query: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427
           K                       +E  P   G                  L +    + 
Sbjct: 361 K-----------------------EESQPVVKGKV----------------LEKKKQKQL 381

Query: 428 VDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487
            D    L A    +++A  S++YI+ ++K ++   ++  DWK+VA V+DRIFLW+F +V 
Sbjct: 382 SDGEKVLVAF---LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVS 438

Query: 488 ILGTAGLFLQPL 499
           + G+  +F   L
Sbjct: 439 VTGSVLIFTPAL 450


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  393 bits (1009), Expect = e-109
 Identities = 220/504 (43%), Positives = 305/504 (60%), Gaps = 81/504 (16%)

Query: 13  SPPRLLLLLLLSLLPVARASEA-------------------EHRLFERLFEDYNEIIRPV 53
           S PR L LLLL  L   R   A                   E  L + LF+DY   +RPV
Sbjct: 6   SGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPV 65

Query: 54  ANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPA 113
            +++D + I F +++SQLV VDE NQ+M TN+WLKQ W D KL+WNP DYGG + +RVP+
Sbjct: 66  EHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPS 125

Query: 114 QKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNC 173
             +W PDIVL++NA G F+    TK +++Y G VTW PPA +KSSC IDVT+FPFD QNC
Sbjct: 126 DSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNC 184

Query: 174 TMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITY 233
           +MKFGSW+YD +++D++L    ++ +D++++GEW I+ A G K +   +CC   YP +TY
Sbjct: 185 SMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCW--YPYVTY 242

Query: 234 SLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITET 293
           S  I+RLPLFYT+ LIIPC+ +SFLTVLVFYLPS+ GEK+ LC SVL+SLTVFLLVI E 
Sbjct: 243 SFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEI 302

Query: 294 IPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTH-TMPSWVKTVFLNLLPR 352
           IPS+S VIPLIGEYL+FTMIFVTLSI++TVF +N+H+R+ +TH  M   V+ +FL+ LP+
Sbjct: 303 IPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPK 362

Query: 353 VMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKI 412
           ++ M R   +    QK     G+              G K                    
Sbjct: 363 LLCM-RSHVDRYFTQKEETESGS--------------GPK-------------------- 387

Query: 413 SNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVA 472
              S+  T  ++ +S+  +        +++E ++  K+IA+                   
Sbjct: 388 ---SSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQ------------------- 425

Query: 473 MVIDRIFLWVFTLVCILGTAGLFL 496
            V+DR+FLW F  V I+G+ GLF+
Sbjct: 426 -VLDRMFLWTFLFVSIVGSLGLFV 448


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  358 bits (918), Expect = 8e-99
 Identities = 189/493 (38%), Positives = 294/493 (59%), Gaps = 17/493 (3%)

Query: 13  SPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLV 72
           SP  + L L  SLL V+   E + +L++ L ++YN + RPVAN S P+ ++F +S+ Q++
Sbjct: 4   SPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIM 63

Query: 73  KVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQ 132
            VDE NQ++ TN+WL+  W D+ L+WN S+Y G + +R P  +IWKPDI+LYN+A   F 
Sbjct: 64  DVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFD 123

Query: 133 VDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI 192
               T  L+  +G   ++PP IFKSSC IDV +FPFD Q+C +KFGSWSY    +DL + 
Sbjct: 124 ATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM- 182

Query: 193 GSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPC 252
               ++  Y  +GEW ++  PG + +  Y CC+E YPD+T+++ +RR  L+Y +NL+IPC
Sbjct: 183 -QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPC 241

Query: 253 LLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTM 312
           +LIS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  +PLI +Y   TM
Sbjct: 242 VLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTM 301

Query: 313 IFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GNAQ 367
           I V LS+V+TV VL  H+  P    MP W + + LN     + M RP  ++      + Q
Sbjct: 302 IIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQ 361

Query: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427
           +   L   E+S +     +       G+   DG+  +C    +   +      R + S +
Sbjct: 362 RRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACSPT 415

Query: 428 VDAVLSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVF 483
            D  L      PE    + + ++ V+YIA   + Q+E++ +  +WK+ A V+DR+ L  F
Sbjct: 416 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 475

Query: 484 TLVCILGTAGLFL 496
           ++  I+ T G+ +
Sbjct: 476 SVFTIICTIGILM 488


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  343 bits (881), Expect = 2e-94
 Identities = 187/501 (37%), Positives = 286/501 (57%), Gaps = 34/501 (6%)

Query: 15  PRLLLLLL----LSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQ 70
           P  LL+LL      L P  R SEAE RL E+LF  Y+  +RP   V D V +   + ++Q
Sbjct: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQ 62

Query: 71  LVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGD 130
           L+ ++E ++ M T ++L   W DY+L W+P+++ G + +R+ A+ +W PD+VL NN  G+
Sbjct: 63  LISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122

Query: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190
           F V      ++   G V W PP I++SSC I VTYFPFD+QNCTM F S+SYD +++ L 
Sbjct: 123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQ 182

Query: 191 L-IGSS--------MNLKDYWESGEWAIIKAPG---YKHDIKYNCCEEIYPDITYSLYIR 238
             +G          ++   + E+G+W II  P              E    ++ + L IR
Sbjct: 183 TGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIR 242

Query: 239 RLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTS 298
           R PLFY +N+I PC+LI+ L + VFYLP D GEK+ L I  LL+LTVFLL++ + +P TS
Sbjct: 243 RKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETS 302

Query: 299 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTR 358
           L +P+I +YL+FTM+ VT S++++V VLN+H+R+P TH MP WV+ +F++ LP  + + R
Sbjct: 303 LSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKR 362

Query: 359 PTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGY---PCQDGMCGYCHHRRIKISNF 415
           P        KP      E  + +       +G  E +   P  D +         K + F
Sbjct: 363 P--------KPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFP-------KPNRF 407

Query: 416 SANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVI 475
              L+       +D      AL PE++E + S+ YIA  ++ Q +   +++DW++VAMV+
Sbjct: 408 QPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVV 467

Query: 476 DRIFLWVFTLVCILGTAGLFL 496
           DR+FLW F +   +GT  +FL
Sbjct: 468 DRLFLWTFIIFTSVGTLVIFL 488


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  339 bits (869), Expect = 4e-93
 Identities = 195/502 (38%), Positives = 288/502 (57%), Gaps = 36/502 (7%)

Query: 17  LLLLLLLSLLPVARA--SEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEVSMSQLV 72
           +L L LL+ L V  +     E RL   LF++  YN+ +RPVA+  + V +   +++S L+
Sbjct: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64

Query: 73  KVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQ 132
            + EV + + TN+W++  W D +LKWN  ++G    +R+P   +W P+IVL NN  G FQ
Sbjct: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQ 124

Query: 133 VDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI 192
           +      L+ + G V W+PPAIF+SSC I VTYFPFD+QNC++KF S  Y   +I L L 
Sbjct: 125 ISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLK 184

Query: 193 GSSMNLKDY---W---------ESGEWAIIKAPGYKH-DIKYNCCEEIYPDITYSLYIRR 239
             +   + Y   W         E+GEW I+  P   + D +         DIT+ L IRR
Sbjct: 185 QDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRR 244

Query: 240 LPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSL 299
            PLFY IN+++PC+LISF+  LVFYLP+D GEK ++ ISVLL+ +VFLL+I++ +P+TS+
Sbjct: 245 KPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSM 304

Query: 300 VIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP 359
            IPLIG++LLF M+ VT+ +VI V VLN+H+RTP+TH +   VK +FL  LP ++ M+RP
Sbjct: 305 AIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRP 364

Query: 360 TSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANL 419
                +   P  L     S+L   S+AE       Y            ++ +    +  L
Sbjct: 365 AE---DGPSPGALV-RRSSSLGYISKAEE------YFLLKSRSDLMFEKQSERHGLARRL 414

Query: 420 TRS----SSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVI 475
           T +    +SSE          L  E+K A+    +I  +M+ QN   E +D W  VA  +
Sbjct: 415 TTARRPPASSEQAQ-----QELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTV 469

Query: 476 DRIFLWVFTLVCILGTAGLFLQ 497
           DR+ L+V T V ++GTA +FLQ
Sbjct: 470 DRLCLFVVTPVMVVGTAWIFLQ 491


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  316 bits (809), Expect = 4e-86
 Identities = 168/471 (35%), Positives = 268/471 (56%), Gaps = 20/471 (4%)

Query: 24  SLLPVARASEAEH--RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIM 81
           S L  A  ++ ++  +LF  LFEDY+  +RPV +    + +  ++++SQ+  +DE NQI+
Sbjct: 18  SRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQIL 77

Query: 82  ETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALL 141
              LW++QIW+D  L W+   Y G + +R+P+  +W+PDIVLYN A  +      T  +L
Sbjct: 78  TAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVL 137

Query: 142 KYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDY 201
           +Y G +TW  PAI KSSC +DVTYFPFD Q C + FGSW+Y+  ++D+     S +L D+
Sbjct: 138 RYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDF 197

Query: 202 WESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVL 261
            E  EW +   P  K+ I Y CC E YPD+T++L ++R   FY +NL+IPC+LISFL  L
Sbjct: 198 IEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPL 257

Query: 262 VFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVI 321
            FYLP+  GEKV+L +++LL++TVF L++ E +P++  V PLIG+Y + TM  +T S  +
Sbjct: 258 SFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTAL 316

Query: 322 TVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNL- 380
           T+ V+N+H+       +P W + V L  + RV+F+      +       P +  E  +L 
Sbjct: 317 TIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFV-----YDVGESCLSPHHSRERDHLT 371

Query: 381 NCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPE 440
             +S+      K     +D       ++R+K ++          +ES  A         +
Sbjct: 372 KVYSKLPESNLKAARN-KDLSRKKDMNKRLK-NDLGCQGKNPQEAESYCA---------Q 420

Query: 441 IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGT 491
            K   ++++YIA+ +K          +WK VA VIDR F+W+F ++  + T
Sbjct: 421 YKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMT 471


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  305 bits (780), Expect = 8e-83
 Identities = 172/484 (35%), Positives = 266/484 (54%), Gaps = 49/484 (10%)

Query: 20  LLLLSLLPVARASEAEHRL----FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVD 75
           LLLL LLP A    AE RL    F  LF +Y   +RPVA+    + +  EV++SQ++ +D
Sbjct: 12  LLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMD 70

Query: 76  EVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDD 135
           E NQ++   LW++Q W D  L+W+P+ YGG + +R+P+  +W+PDIVLYN A        
Sbjct: 71  ERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSA 130

Query: 136 KTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS 195
            T  +L++ G V W  PAI +SSC++DV  FPFD Q+C + FGSW++   ++D+   G++
Sbjct: 131 STNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAA 190

Query: 196 MNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLI 255
            +L D+ E+ EW ++  P  +  + Y CC E YPD+T++L +RR    Y  NL++PC+LI
Sbjct: 191 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250

Query: 256 SFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFV 315
           S L  L F+LP+D GEKV+L ++VLL+LTVF L++ E++P    V PLIG+Y + TM  V
Sbjct: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMV 309

Query: 316 TLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGA 375
           T S  +T+ ++N+HY  P+   +P+W + + L  L R + +       G ++ P      
Sbjct: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPP------ 363

Query: 376 ELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLS 435
           ELS        +S     G P      G CH  R         L R  +           
Sbjct: 364 ELS-----PSPQSPEGGAGPP-----AGPCHEPRC--------LCRQEA----------- 394

Query: 436 ALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLF 495
                    +  V  IA   ++   A+   +DWK +A V+DR FL +F  + ++ +  + 
Sbjct: 395 --------LLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVL 446

Query: 496 LQPL 499
           +Q L
Sbjct: 447 VQAL 450


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  301 bits (771), Expect = 9e-82
 Identities = 177/489 (36%), Positives = 271/489 (55%), Gaps = 32/489 (6%)

Query: 19  LLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVN 78
           +LLLL LL        E RL+  LF +Y+   RPV    D V I  +V+++ L+ ++E  
Sbjct: 8   VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKE 67

Query: 79  QIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTK 138
           + + T++W+   W DY+L ++  D+GG E +RVP++ +W P+IVL NN  G F V     
Sbjct: 68  ETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDAN 127

Query: 139 ALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLI----GS 194
            L+   G VTW+PPAI++S C ++VTYFPFD+QNC++ F S +Y+  +++        G 
Sbjct: 128 VLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGK 187

Query: 195 SMNLKD-----YWESGEWAIIKAPGYKHDIKYNCCE-EIYPDITYSLYIRRLPLFYTINL 248
           ++N  D     Y E+GEWAI   PG          +     D+ YSL IRR PLFY IN+
Sbjct: 188 TINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINI 247

Query: 249 IIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEY 307
           I+PC+LIS L +L ++LP+   G+K T+ I+VLL+ TVFL +I + IP TSL +PL+G +
Sbjct: 248 IVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRF 307

Query: 308 LLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ 367
           L+F M+  TL ++  V VLNV  RTPTTH M   ++ V L LLPR++    P      A 
Sbjct: 308 LIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAAS 367

Query: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427
            PR       S++    RAE    K+  P  + +     HR+     ++A   +      
Sbjct: 368 PPR-----RASSVGLLLRAEELILKK--PRSELVFEGQRHRQ---GTWTAAFCQ------ 411

Query: 428 VDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487
                SL A +PE++  + +V ++AE+ + Q    E   DW  +   +D I  W   ++ 
Sbjct: 412 -----SLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLF 466

Query: 488 ILGTAGLFL 496
            +G++ +FL
Sbjct: 467 SVGSSLIFL 475


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  278 bits (710), Expect = 1e-74
 Identities = 169/497 (34%), Positives = 264/497 (53%), Gaps = 28/497 (5%)

Query: 17  LLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDE 76
           LLLLLLL++   A+    E RL   L ++Y+  +RP    SD V +  +++++ L+ ++E
Sbjct: 8   LLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNE 67

Query: 77  VNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDK 136
             + + TN+W++  W DY+L+W+P DY G   +RVP+  +W+PDIVL NN  G F+V   
Sbjct: 68  REEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALY 127

Query: 137 TKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS- 195
              L+   G + W+PPAIF+S+C I VTYFPFD+QNC++ F S +Y   +IDL L     
Sbjct: 128 CNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDG 187

Query: 196 -------MNLKDYWESGEWAIIKAPG-YKHDIKYNCCEEIYPDITYSLYIRRLPLFYTIN 247
                  ++ + + E+GEWAI   P     D      E  +  + + L I+R PLFY IN
Sbjct: 188 QTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVIN 247

Query: 248 LIIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE 306
           +I PC+LIS + +L+ +LP+   G+K T+ I+VLL+ TVFL ++ + +P TS  +PLI +
Sbjct: 248 IIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISK 307

Query: 307 YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNA 366
           YL F ++   L +V  V VLNV  R+P TH+M   V+ VFL LLP+++ M          
Sbjct: 308 YLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRM---------- 357

Query: 367 QKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMC-------GYCHHRRIKISNFSANL 419
              RPL  A + +     +  S G       +  +C            R+  ++     L
Sbjct: 358 -HVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKL 416

Query: 420 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF 479
            +           SL   +P I+  +++   IA     Q+      ++W  V  V+DR+ 
Sbjct: 417 EKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVC 476

Query: 480 LWVFTLVCILGTAGLFL 496
                 + I GTAG+FL
Sbjct: 477 FLAMLSLFICGTAGIFL 493


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  249 bits (637), Expect = 3e-66
 Identities = 137/375 (36%), Positives = 214/375 (57%), Gaps = 17/375 (4%)

Query: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190
           F     T  L+  +G   ++PP IFKSSC IDV +FPFD Q+C +KFGSWSY    +DL 
Sbjct: 32  FDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 91

Query: 191 LIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLII 250
           +     ++  Y  +GEW ++  PG + +  Y CC+E YPD+T+++ +RR  L+Y +NL+I
Sbjct: 92  M--QEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 149

Query: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310
           PC+LIS L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  +PLI +Y   
Sbjct: 150 PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 209

Query: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GN 365
           TMI V LS+V+TV VL  H+  P    MP W + + LN     + M RP  ++      +
Sbjct: 210 TMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQH 269

Query: 366 AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSS 425
            Q+   L   E+S +     +       G+   DG+  +C    +   +      R + S
Sbjct: 270 KQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACS 323

Query: 426 ESVDAVLSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLW 481
            + D  L      PE    + + ++ V+YIA   + Q+E++ +  +WK+ A V+DR+ L 
Sbjct: 324 PTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 383

Query: 482 VFTLVCILGTAGLFL 496
            F++  I+ T G+ +
Sbjct: 384 AFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  202 bits (513), Expect = 8e-52
 Identities = 122/483 (25%), Positives = 234/483 (48%), Gaps = 40/483 (8%)

Query: 17  LLLLLLLSLLPVARASEAEH-------RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMS 69
           LL LLL +LL    A  + +       RL + L  +Y + +RPV +   P  +  +V + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 70  QLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVG 129
            ++ VDE NQ++ T +W +Q W D  L+WNP D+     + +P   IW PDI++ N  V 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI-NEFVD 133

Query: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189
             +  +     +++ GEV    P    ++C +D+  FPFD QNC++ F SW +    I++
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 190 VLIGSSMNLKD----YWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYT 245
            L      +K     +   GEW ++    Y  +         Y ++ + + IRR PLFY 
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252

Query: 246 INLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIG 305
           ++L++P + +  + ++ FYLP + GE+V+  I++LL  +VFL+++++T+P+T++  PLIG
Sbjct: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312

Query: 306 EYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGN 365
            Y +  M  + +S+  T+F++ + ++      +P+W++ + L  +  ++ +      +  
Sbjct: 313 VYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCL----REQST 368

Query: 366 AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSS 425
           +Q+P P         +C                  M  +C H      +F  +     S 
Sbjct: 369 SQRP-PATSQATKTDDC----------------SAMGNHCSHMG-GPQDFEKSPRDRCSP 410

Query: 426 ESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTL 485
                  SL+         +Q +  I + ++ ++E +E+  DW  V  V+D++   ++ L
Sbjct: 411 PPPPREASLAVCG-----LLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465

Query: 486 VCI 488
             +
Sbjct: 466 AVL 468


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  198 bits (504), Expect = 8e-51
 Identities = 114/456 (25%), Positives = 223/456 (48%), Gaps = 33/456 (7%)

Query: 37  RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKL 96
           RL + L  +Y + +RPV +   P  +  +V +  ++ VDE NQ++ T +W +Q W D  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 97  KWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFK 156
           +WNP D+     + +P   IW PDI++ N  V   +  +     +++ GEV    P    
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDILI-NEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVV 139

Query: 157 SSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKD----YWESGEWAIIKA 212
           ++C +D+  FPFD QNC++ F SW +    I++ L      +K     +   GEW ++  
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGV 199

Query: 213 PGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEK 272
             Y  +         Y ++ + + IRR PLFY ++L++P + +  + ++ FYLP + GE+
Sbjct: 200 LPYFREFSMES-SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGER 258

Query: 273 VTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRT 332
           V+  I++LL  +VFL+++++T+P+T++  PLIG Y +  M  + +S+  T+F++ + ++ 
Sbjct: 259 VSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQ 318

Query: 333 PTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCK 392
                +P+W++ + L  +  ++ +      +  +Q+P P         +C          
Sbjct: 319 DLQQPVPAWLRHLVLERIAWLLCL----REQSTSQRP-PATSQATKTDDC---------- 363

Query: 393 EGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIA 452
                   M  +C H      +F  +     S        SL+         +Q +  I 
Sbjct: 364 ------SAMGNHCSHMG-GPQDFEKSPRDRCSPPPPPREASLAVCG-----LLQELSSIR 411

Query: 453 ENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCI 488
           + ++ ++E +E+  DW  V  V+D++   ++ L  +
Sbjct: 412 QFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 447


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  191 bits (485), Expect = 1e-48
 Identities = 107/309 (34%), Positives = 175/309 (56%), Gaps = 15/309 (4%)

Query: 197 NLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLIS 256
           ++  Y  +GEW ++  PG + +  Y CC+E YPD+T+++ +RR  L+Y +NL+IPC+LIS
Sbjct: 5   DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLIS 64

Query: 257 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVT 316
            L +LVF LP+D GEK++L I+VLLSLTVF+L++ E +P+TS  +PLI +Y   TMI V 
Sbjct: 65  ALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVG 124

Query: 317 LSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNE-----GNAQKPRP 371
           LS+V+TV VL  H+  P    MP W + + LN     + M RP  ++      + Q+   
Sbjct: 125 LSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCS 184

Query: 372 LYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAV 431
           L   E+S +     +       G+   DG+  +C    +   +      R + S + D  
Sbjct: 185 LASVEMSAVAPPPASNGNLLYIGFRGLDGV--HC----VPTPDSGVVCGRMACSPTHDEH 238

Query: 432 LSLSALSPE----IKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487
           L      PE    + + ++ V+YIA   + Q+E++ +  +WK+ A V+DR+ L  F++  
Sbjct: 239 LLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFT 298

Query: 488 ILGTAGLFL 496
           I+ T G+ +
Sbjct: 299 IICTIGILM 307


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  186 bits (473), Expect = 3e-47
 Identities = 122/515 (23%), Positives = 235/515 (45%), Gaps = 72/515 (13%)

Query: 17  LLLLLLLSLLPVARASEAEH-------RLFERLFEDYNEIIRPVANVSDPVIIHFEVSMS 69
           LL LLL +LL    A  + +       RL + L  +Y + +RPV +   P  +  +V + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 70  QLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVG 129
            ++ VDE NQ++ T +W +Q W D  L+WNP D+     + +P   IW PDI++ N  V 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILI-NEFVD 133

Query: 130 DFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDL 189
             +  +     +++ GEV    P    ++C +D+  FPFD QNC++ F SW +    I++
Sbjct: 134 VGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 190 VLIGSSMNLKD----YWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYT 245
            L      +K     +   GEW ++    Y  +         Y ++ + + IRR PLFY 
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252

Query: 246 INLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIG 305
           ++L++P + +  + ++ FYLP + GE+V+  I++LL  +VFL+++++T+P+T++  PLIG
Sbjct: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312

Query: 306 E--------------------------------YLLFTMIFVTLSIVITVFVLNVHYRTP 333
           +                                Y +  M  + +S+  T+F++ + ++  
Sbjct: 313 KAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD 372

Query: 334 TTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKE 393
               +P+W++ + L  +  ++ +      +  +Q+P P         +C           
Sbjct: 373 LQQPVPAWLRHLVLERIAWLLCL----REQSTSQRP-PATSQATKTDDC----------- 416

Query: 394 GYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAE 453
                  M  +C H      +F  +     S        SL+         +Q +  I +
Sbjct: 417 -----SAMGNHCSHMG-GPQDFEKSPRDRCSPPPPPREASLAVCG-----LLQELSSIRQ 465

Query: 454 NMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCI 488
            ++ ++E +E+  DW  V  V+D++   ++ L  +
Sbjct: 466 FLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 500


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  159 bits (401), Expect = 7e-39
 Identities = 95/313 (30%), Positives = 159/313 (50%), Gaps = 29/313 (9%)

Query: 51  RPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMR 110
           RPV N+S P  ++   +MS ++ V+E   ++ + LWL+ +W++  + WNP +  G   M 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 111 VPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYT---GEVTWIPPAIFKSSCKIDVTYFP 167
           + A+ +W PDI +    +    VD   K L  Y    G + +  P    S C +D+ YFP
Sbjct: 130 MAAKNLWLPDIFI----IELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185

Query: 168 FDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWE-----------SGEWAIIKAPGYK 216
           FD QNCT+ F S+ Y    +D +L+      K+ WE            GEW ++     K
Sbjct: 186 FDQQNCTLTFSSFLY---TVDSMLLDME---KEVWEITDASRNILQTHGEWELLGLS--K 237

Query: 217 HDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLC 276
              K +    +Y  I + + IRR P  Y INL++P   +  +  L FYLP   G +V   
Sbjct: 238 ATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFK 297

Query: 277 ISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHYRTPTT 335
           I++LL   VFLL++++ +P++    PLIG Y    +  +  S++ T+F+ + +H  T   
Sbjct: 298 ITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQP 355

Query: 336 HTMPSWVKTVFLN 348
             +P W+ ++ L+
Sbjct: 356 PPLPRWLHSLLLH 368


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  154 bits (388), Expect = 2e-37
 Identities = 93/323 (28%), Positives = 160/323 (49%), Gaps = 25/323 (7%)

Query: 38  LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK 97
           +F+ +F+   +  RP  N S P  ++   ++S ++ VD   Q++ + LW+  +W++  + 
Sbjct: 44  VFQAVFD--RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFIN 101

Query: 98  WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS 157
           WNP +  G   + V A+ +W PDI +  +   D Q      A +   G + +  P    S
Sbjct: 102 WNPKECVGINKLTVLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTS 160

Query: 158 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWE-----------SGE 206
            C +D+ YFPFD QNCT  F S+ Y    +D +L+G     K+ WE            GE
Sbjct: 161 ICNLDIFYFPFDQQNCTFTFSSFLYT---VDSMLLGMD---KEVWEITDTSRKVIQTQGE 214

Query: 207 WAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLP 266
           W ++     K   K +    +Y  I + + IRR P  Y INL++P   +  +  L FYLP
Sbjct: 215 WELLGIN--KATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLP 272

Query: 267 SDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326
           ++   +    I++LL   VFLL++ + +P++    PLI  Y    +  + +S++ TVF+ 
Sbjct: 273 AESENRAPFKITLLLGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFIT 330

Query: 327 N-VHYRTPTTHTMPSWVKTVFLN 348
             +H  T     MP W+ ++ L+
Sbjct: 331 YLLHVATTQPPPMPRWLHSLLLH 353


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  147 bits (370), Expect = 3e-35
 Identities = 79/297 (26%), Positives = 154/297 (51%), Gaps = 7/297 (2%)

Query: 34  AEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWND 93
           A + L ++L + Y++ +RPV N +    ++ ++ +  ++ VD  NQI++T++W +++WND
Sbjct: 31  ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90

Query: 94  YKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPA 153
             L WN S +     + +P   IW PDI++ N  V   +  D     +  +G +    P 
Sbjct: 91  EFLSWNSSMFDEIREISLPLSAIWAPDIII-NEFVDIERYPDLPYVYVNSSGTIENYKPI 149

Query: 154 IFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNL----KDYWESGEWAI 209
              S+C ++   FPFD QNC++ F S  +    +DL  + S  ++    K +    EW +
Sbjct: 150 QVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWEL 209

Query: 210 IKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC 269
           +        ++ +     +  I +++ +RR PL Y ++L+IP + +  + +  FYLP +C
Sbjct: 210 LSVSSTYSILQSSAGG--FAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNC 267

Query: 270 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326
             ++    SVL+  TVF + ++  +P +    PLIG +    M F+ LS+  ++ ++
Sbjct: 268 RARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 82/301 (27%), Positives = 131/301 (43%), Gaps = 32/301 (10%)

Query: 38  LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK 97
           +  RL   Y+  IRP      PV +   + ++    + E       N++L+Q WND +LK
Sbjct: 59  ILNRLLVSYDPRIRPNFK-GIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLK 117

Query: 98  WNPSDYGGAEFMRVPAQK---IWKPDIVLYNNAVGDFQVDDKTKALLKY--TGEVTWIPP 152
             PSD+ G++ + V       +WKPD+   N    +F    +   LL     G+V     
Sbjct: 118 L-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMR 176

Query: 153 AIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESG---EWAI 209
                SC +D+T FP D Q C M+  S+ Y           ++ +L+  W+SG   +   
Sbjct: 177 LSITLSCPLDLTLFPMDTQRCKMQLESFGY-----------TTDDLRFIWQSGDPVQLEK 225

Query: 210 IKAPGY---KHDIKYNCCEEIYPDITY------SLYIRRLPLFYTINLIIPCLLISFLTV 260
           I  P +   K DI+Y  C + Y    Y         +RR   FY + +  P LLI  L+ 
Sbjct: 226 IALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSW 285

Query: 261 LVFYL-PSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSI 319
           L F++ P     +V L I  +LSL      +   +P  S V   +  +L+  ++F   S+
Sbjct: 286 LSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYV-KALDVWLIACLLFGFASL 344

Query: 320 V 320
           V
Sbjct: 345 V 345


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 78/350 (22%), Positives = 154/350 (44%), Gaps = 39/350 (11%)

Query: 2   GSGPLSLPLALSPPRLLLLLLLSLLP--VARASEAEHR---------------------L 38
           GS   S P+      + +LLLLSL P   ++ S+ ++                      +
Sbjct: 10  GSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVI 69

Query: 39  FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW 98
              L E Y+  +RP   V  P +IH ++ ++ +  V+ +N     +++  Q W D +LK+
Sbjct: 70  LNNLLEGYDNKLRPDIGVK-PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF 128

Query: 99  NPSDYGGAEFMRVPAQ---KIWKPDIVLYNNAVGDFQVDDKTKALLKY--TGEVTWIPPA 153
           N +     + +R+ +    KIW PD    N+   D         +L+    G V +    
Sbjct: 129 NST----IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRL 184

Query: 154 IFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKD--YWESGEWAIIK 211
              + C++ +  FP D  +C ++F S+ Y + +I      SS+ + D   W   +++ + 
Sbjct: 185 TIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVG 244

Query: 212 APGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC-G 270
                  +K    + +   + + L  RR+  ++TI   IPC LI  L+ + F++  D   
Sbjct: 245 LRNTTEVVKTTSGDYVVMSVYFDL-SRRMG-YFTIQTYIPCTLIVVLSWVSFWINKDAVP 302

Query: 271 EKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIV 320
            + +L I+ +L++T    +  +++P  S V  +   ++    IFV  ++V
Sbjct: 303 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM-DLFVSVCFIFVFSALV 351


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 78/350 (22%), Positives = 154/350 (44%), Gaps = 39/350 (11%)

Query: 2   GSGPLSLPLALSPPRLLLLLLLSLLP--VARASEAEHR---------------------L 38
           GS   S P+      + +LLLLSL P   ++ S+ ++                      +
Sbjct: 10  GSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVI 69

Query: 39  FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW 98
              L E Y+  +RP   V  P +IH ++ ++ +  V+ +N     +++  Q W D +LK+
Sbjct: 70  LNNLLEGYDNKLRPDIGVK-PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF 128

Query: 99  NPSDYGGAEFMRVPAQ---KIWKPDIVLYNNAVGDFQVDDKTKALLKY--TGEVTWIPPA 153
           N +     + +R+ +    KIW PD    N+   D         +L+    G V +    
Sbjct: 129 NST----IKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRL 184

Query: 154 IFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKD--YWESGEWAIIK 211
              + C++ +  FP D  +C ++F S+ Y + +I      SS+ + D   W   +++ + 
Sbjct: 185 TIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVG 244

Query: 212 APGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC-G 270
                  +K    + +   + + L  RR+  ++TI   IPC LI  L+ + F++  D   
Sbjct: 245 LRNTTEVVKTTSGDYVVMSVYFDL-SRRMG-YFTIQTYIPCTLIVVLSWVSFWINKDAVP 302

Query: 271 EKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIV 320
            + +L I+ +L++T    +  +++P  S V  +   ++    IFV  ++V
Sbjct: 303 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAM-DLFVSVCFIFVFSALV 351


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 73/300 (24%), Positives = 131/300 (43%), Gaps = 28/300 (9%)

Query: 40  ERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWN 99
           +RL + Y+  +RP      PV +   + ++ +  V EVN      ++ +Q W D +L ++
Sbjct: 42  DRLLKGYDIRLRPDFG-GPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100

Query: 100 PSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQ-VDDKTKAL-LKYTGEVTWIPPAIFKS 157
                     RV A ++W PD    N+       V  K + + L   G V +       +
Sbjct: 101 GIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTA 159

Query: 158 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAI-----IKA 212
           +C +D+  +P D QNCT++  S+ Y    I+            YW  GE A+     I+ 
Sbjct: 160 ACMMDLRRYPLDEQNCTLEIESYGYTTDDIEF-----------YWNGGEGAVTGVNKIEL 208

Query: 213 PGYK------HDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLP 266
           P +          K       YP ++ S  ++R   ++ +   +P  LI+ L+ + F++ 
Sbjct: 209 PQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWIN 268

Query: 267 SDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 325
            D    +V L I+ +L++T     + ET+P    V   I  YL+   +FV L+++   FV
Sbjct: 269 YDASAARVALGITTVLTMTTISTHLRETLPKIPYV-KAIDIYLMGCFVFVFLALLEYAFV 327


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 73/379 (19%), Positives = 159/379 (41%), Gaps = 19/379 (5%)

Query: 38  LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK 97
           +  +L  +Y++ +RP   +  P +I  ++ ++ +  V  +N   + +++  Q W D +L+
Sbjct: 50  ILNKLLREYDKKLRPDIGIK-PTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLR 108

Query: 98  WNPSDYGGAEFMRVPAQK---IWKPDIVLYNNAVGDFQVDDKTKALLKY--TGEVTWIPP 152
           +N +     + + + +     IW PD +  N+   +         LL+    G++ +   
Sbjct: 109 FNST----MKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLR 164

Query: 153 AIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDY--WESGEWAII 210
               + C++ +  FP D  +C + F S+ Y K ++      +S+   D   W   ++  +
Sbjct: 165 LTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFM 224

Query: 211 KAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC- 269
                   +  +  + +   I + L  RR+  ++TI   IPC+L   L+ + F++  D  
Sbjct: 225 GLRNTTEIVTTSAGDYVVMTIYFEL-SRRMG-YFTIQTYIPCILTVVLSWVSFWIKKDAT 282

Query: 270 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPL-IGEYLLFTMIFVTLSIVITVFVLNV 328
             +  L I+ +L++T    +  +++P  S V  + +   + F  +F  L    T+   + 
Sbjct: 283 PARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSS 342

Query: 329 HYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAES 388
             +  TT    S +       +P  + +  P++      +P P     L+N   +   E 
Sbjct: 343 CRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFED 402

Query: 389 K---GCKEGYPCQDGMCGY 404
                C +G  CQ   C Y
Sbjct: 403 TCVYECLDGKDCQSFFCCY 421


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,511,685
Number of Sequences: 37866
Number of extensions: 780347
Number of successful extensions: 2226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 2026
Number of HSP's gapped (non-prelim): 120
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.