Search of human proteins with 19743565

Search of human proteins with 19743565

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide
1 [Homo sapiens]
         (491 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   985   0.0  
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   524   e-149
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   521   e-148
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   520   e-147
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   515   e-146
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   505   e-143
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   503   e-142
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   499   e-141
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   492   e-139
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   490   e-138
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   440   e-123
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   415   e-116
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   395   e-110
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   331   1e-90
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   329   3e-90
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   327   1e-89
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   303   2e-82
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   286   4e-77
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   244   1e-64
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   241   1e-63
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   224   1e-58
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   218   1e-56
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   192   8e-49
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  190   3e-48
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   166   6e-41
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   125   1e-28
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   120   3e-27
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   118   1e-26
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   112   8e-25
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   107   2e-23

>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  985 bits (2546), Expect = 0.0
 Identities = 491/491 (100%), Positives = 491/491 (100%)

Query: 1   MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60
           MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK
Sbjct: 1   MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60

Query: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR 120
           EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR
Sbjct: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR 120

Query: 121 WKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIIC 180
           WKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIIC
Sbjct: 121 WKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIIC 180

Query: 181 SVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKC 240
           SVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKC
Sbjct: 181 SVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKC 240

Query: 241 LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT 300
           LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT
Sbjct: 241 LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT 300

Query: 301 KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA 360
           KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA
Sbjct: 301 KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA 360

Query: 361 DIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSF 420
           DIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSF
Sbjct: 361 DIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSF 420

Query: 421 KKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNL 480
           KKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNL
Sbjct: 421 KKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNL 480

Query: 481 PRPFQLCLRPR 491
           PRPFQLCLRPR
Sbjct: 481 PRPFQLCLRPR 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  524 bits (1350), Expect = e-149
 Identities = 257/491 (52%), Positives = 349/491 (71%), Gaps = 4/491 (0%)

Query: 5   STAILLLLLALVCLLLTLS----SRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSK 60
           S  +L+ LLA + +++ +S     + +GKLPPGP PL  +GN L L ++ M  SL K+S+
Sbjct: 4   SGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISE 63

Query: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR 120
            YG ++T+HLGPRRVVVL G+ AVKEALVDQ EEFSGRG+   F    KG G+AFS+G+R
Sbjct: 64  RYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGER 123

Query: 121 WKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIIC 180
            K LR+FSI  LR FG+GKR IEERI EE  FL+  LR T G   DPTF LSR+VSN+I 
Sbjct: 124 AKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVIS 183

Query: 181 SVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKC 240
           S++FG RFDY+D+  L+++R++  +FQ  ++  G+LY++F S++  +PGP Q+ F+  + 
Sbjct: 184 SIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQG 243

Query: 241 LRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGT 300
           L D IA  V  +Q +LDP SPRDFI  FL +M EE+++P + F++  L+MTT NL F GT
Sbjct: 244 LEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGT 303

Query: 301 KTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFA 360
           +TVSTTL + FL LMK+P+V+A+V EEID V+G+ R P  +DRA MPYT+AVIHE+QRF 
Sbjct: 304 ETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFG 363

Query: 361 DIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSF 420
           D++PM L HRV +DT FR F +PKGT+V  +L +V  DP  F  P++FNP+HFLD    F
Sbjct: 364 DMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQF 423

Query: 421 KKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNL 480
           KKS AF+PFS G+R C GE LARMELFL+ T I+Q+F  +   +P+DID++P   G   +
Sbjct: 424 KKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATI 483

Query: 481 PRPFQLCLRPR 491
           PR + +   PR
Sbjct: 484 PRNYTMSFLPR 494


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  521 bits (1343), Expect = e-148
 Identities = 250/486 (51%), Positives = 344/486 (70%)

Query: 5   STAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGS 64
           + A++L L  L  L L   S  +G+LP GP PL I+GN+L L  +DM  SLT  SK YG 
Sbjct: 4   AVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP 63

Query: 65  MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVL 124
           ++TV+ G + +VVL GY+AVKEAL+D GEEFSGRG +P      KG GI FS+G RWK +
Sbjct: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123

Query: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLF 184
           R+F +  LRNFGMGKRSIE+R+ EE   L+ ELRKT   P DPTF+L  +  N+ICSV+F
Sbjct: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183

Query: 185 GSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDL 244
             RFDY D+R L ++   N+N +I+SSPW ++ + FP+L+D++PG H +I +NF  ++  
Sbjct: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSY 243

Query: 245 IAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVS 304
           +   + +HQ SLD  S RDFI CFL KM +EK +  S F +++L+ T  ++   GT+T S
Sbjct: 244 VLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTS 303

Query: 305 TTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIP 364
           TTL +  L L+KYP+V A+VQEEI+ VVGR R P ++DR+ MPYTDAV+HE+QR+ D++P
Sbjct: 304 TTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLP 363

Query: 365 MNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSP 424
            NLPH VT D  F+ +LIPKGT +IT L +V ++  +F  P+ F+P HFLD + +FKKS 
Sbjct: 364 TNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSD 423

Query: 425 AFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPF 484
            FMPFSAG+R+C+GE LARMELFL+LT ILQ+F+L+    P+DID+TP+++  G +P  +
Sbjct: 424 YFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLY 483

Query: 485 QLCLRP 490
           QLC  P
Sbjct: 484 QLCFIP 489


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  520 bits (1339), Expect = e-147
 Identities = 256/485 (52%), Positives = 344/485 (70%)

Query: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66
           A+L+ L  +V + +    + KGKLPPGP PL  +GN L L ++ M  SL K+S+ YG ++
Sbjct: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69

Query: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126
           T+HLGPRRVVVL G+ AV+EALVDQ EEFSGRG+   F    KG G+ FS+G+R K LR+
Sbjct: 70  TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRR 129

Query: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
           FSI  LR+FG+GKR IEERI EE  FL+  LR T G   DPTF LSR+VSN+I S++FG 
Sbjct: 130 FSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGD 189

Query: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246
           RFDY D+  L+++R++   FQ  S+  G+LY++F S++  +PGP Q+ FQ  + L D IA
Sbjct: 190 RFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIA 249

Query: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306
             V  +Q +LDP SPRDFI  FL +M EE+++P + F++  L+MTT NL  GGT+TVSTT
Sbjct: 250 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTT 309

Query: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DRA MPY +AVIHE+QRF D+IPM+
Sbjct: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMS 369

Query: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFL+    FKKS AF
Sbjct: 370 LARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAF 429

Query: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P   G   +PR + +
Sbjct: 430 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTM 489

Query: 487 CLRPR 491
              PR
Sbjct: 490 SFLPR 494


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  515 bits (1327), Expect = e-146
 Identities = 248/485 (51%), Positives = 348/485 (71%), Gaps = 3/485 (0%)

Query: 9   LLLLLALVCLLLTL---SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSM 65
           ++L+L L CLLL      S  +GKLPPGP PL ++GN+L +  +D+  SLT LSK YG +
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 66  YTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLR 125
           +T++ G  R+VVL GY+ VKEAL+D GEEFSGRG +P      +G GI FS+G RWK +R
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 126 QFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFG 185
           +FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICS++F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 186 SRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLI 245
            RFDY D++ L ++  +N+N +I+S+PW ++ + FP+++D+ PG H ++ +N   +   I
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 246 AHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVST 305
              V +HQ S+D  +PRDFI CFL KM +EK++  S F ++ L++T  +LL  GT+T ST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 306 TLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPM 365
           TL +A L L+K+P+V A+VQEEI+ V+GR R P ++DR  MPYTDAV+HEVQR+ D+IP 
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 366 NLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPA 425
           +LPH VT D  FR +LIPKGT ++T L +V +D  +F  P+ F+P HFLD   +FKKS  
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 426 FMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQ 485
           FMPFSAG+R+C+GE LARMELFL+LT ILQ+F+L+ L  P+D+D TP+ +G  ++P  +Q
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 486 LCLRP 490
           LC  P
Sbjct: 485 LCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  505 bits (1300), Expect = e-143
 Identities = 245/484 (50%), Positives = 341/484 (70%), Gaps = 1/484 (0%)

Query: 8   ILLLLLALVCLL-LTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66
           +L+L L+ + L  L   S  + KLPPGP PL I+GN+L +  +D+  S T  SK YG ++
Sbjct: 6   VLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVF 65

Query: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126
           TV+ G   +VV  GY+AVKEAL+D GEEFSGRG+ P     TKG GI  S+G RWK +R+
Sbjct: 66  TVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRR 125

Query: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
           FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICSV+F  
Sbjct: 126 FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK 185

Query: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246
           RFDY D+  LT+++  N+NF+I++SPW ++ + FP L+D  PG H ++ +N    R  I 
Sbjct: 186 RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIR 245

Query: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306
             V +HQASLD  +PRDFI CFL KM +EK++  S F+++ L+ T  +L   GT+T STT
Sbjct: 246 EKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTT 305

Query: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366
           L +  L L+K+P+V A+VQEEID V+GR R P ++DR+ MPYTDAV+HE+QR++D++P  
Sbjct: 306 LRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG 365

Query: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426
           +PH VT DT FR +LIPKGT ++ LL +V +D  +F  P  F+P HFLD N +FKKS  F
Sbjct: 366 VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYF 425

Query: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486
           MPFSAG+R+C GE LARMELFL+LT ILQ+F+L+ +   ++++ T ++ G+ +LP  +Q+
Sbjct: 426 MPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQI 485

Query: 487 CLRP 490
           C  P
Sbjct: 486 CFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  503 bits (1294), Expect = e-142
 Identities = 241/487 (49%), Positives = 348/487 (71%), Gaps = 3/487 (0%)

Query: 7   AILLLLLALVCLLLTL---SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63
           ++++L+L L CLLL      S  +GKLPPGP PL ++GN+L +  +D+  SLT LSK YG
Sbjct: 3   SLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYG 62

Query: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123
            ++T++ G + +VVL GY+AVKEAL+D GEEFSGRG +P      +G GI FS+G +WK 
Sbjct: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122

Query: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
           +R+FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICS++
Sbjct: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182

Query: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
           F  RFDY D++ L ++  +N+N +I+SSPW ++ + F  ++D+ PG H ++ +N   ++ 
Sbjct: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242

Query: 244 LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303
            I   V +HQ S+D  +P+DFI CFL KM +EK +  S F +++L  T  +L   GT+T 
Sbjct: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302

Query: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADII 363
           STTL +A L L+K+P+V A+VQEEI+ V+GR R P ++DR+ MPYTDAV+HEVQR+ D++
Sbjct: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362

Query: 364 PMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKS 423
           P +LPH VT D  FR +LIPKGT ++  L +V +D  +F  P+ F+P HFLD   +FKKS
Sbjct: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422

Query: 424 PAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRP 483
             FMPFSAG+R+C+GE+LA MELFL+LT+ILQ+F+L+ L  P+++D TP+ +G  ++P  
Sbjct: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPF 482

Query: 484 FQLCLRP 490
           +QLC  P
Sbjct: 483 YQLCFIP 489


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  499 bits (1286), Expect = e-141
 Identities = 245/485 (50%), Positives = 338/485 (69%)

Query: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66
           A+L  L  +V + +    + +GKLPPGP PL  +GN L L ++ +  S+ K S+ YG ++
Sbjct: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVF 69

Query: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126
           T+HLGPRRVVVL G+ AV+EALVDQ EEFSGRG+   F    KG G+AFS+G+R K L +
Sbjct: 70  TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLR 129

Query: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
           F+I  LR+FG+GKR IEERI EE  FL+  +R T G   DPTF LSR+VSN+I S++FG 
Sbjct: 130 FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 189

Query: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246
           RFDY+D+  L+++ ++   FQ  S+  G+LY++F S++  +PGP Q+ F+  + L D IA
Sbjct: 190 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 249

Query: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306
             V  +Q +LDP SP+DFI  FL  M EE+++P + F++  L+M+T NL   GT+TVSTT
Sbjct: 250 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 309

Query: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DR  MPY +AVIHE+QRF D+IPM+
Sbjct: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 369

Query: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFLD    FKKS AF
Sbjct: 370 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 429

Query: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P       +PR + +
Sbjct: 430 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 489

Query: 487 CLRPR 491
              PR
Sbjct: 490 SFLPR 494


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  492 bits (1267), Expect = e-139
 Identities = 236/493 (47%), Positives = 340/493 (68%), Gaps = 3/493 (0%)

Query: 1   MDSISTAILLLLLALVCLLLTL--SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKL 58
           M ++   + LL+ A   LL+++         LPPGP PL I+GNL  L  +++  S T+L
Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

Query: 59  SKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSG 118
           ++ +G ++T+++G +R+VV+ GY+AVKEAL+D  +EFSGRGD PAF +  +  GI F++G
Sbjct: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNG 119

Query: 119 DRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNI 178
             WK +R+FS+  LRN+GMGK+  E RI  E  FLL  LRKT+G+PFDPTF++  +  N+
Sbjct: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179

Query: 179 ICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNF 238
           I  +LF   FDY+DE+ L ++ L N+NF ++S+PW +LY+ FPS L ++PG H+++ +N 
Sbjct: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239

Query: 239 KCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFG 298
             +++ ++  V +H  SLDP  PRD   C L +M +EK      + MD + +T  +L F 
Sbjct: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299

Query: 299 GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQR 358
           GT+T STTL +  L LMKYP+++ ++ EEID V+G +R+PA+KDR  MPY DAV+HE+QR
Sbjct: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359

Query: 359 FADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQ 418
           F  ++P NLPH  TRDT FRG+LIPKGT V+  L++V YD  +F  P++F PEHFL+ N 
Sbjct: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419

Query: 419 SFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLG 478
            FK S  F PFS G+R+C GE LARMELFL L AILQ F+L+PL  P+DIDL+P+  G G
Sbjct: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFG 479

Query: 479 NLPRPFQLCLRPR 491
            +P  ++LC+ PR
Sbjct: 480 CIPPRYKLCVIPR 492


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  490 bits (1261), Expect = e-138
 Identities = 238/488 (48%), Positives = 334/488 (68%), Gaps = 3/488 (0%)

Query: 7   AILLLLLALVCLLLTLSSRDKG---KLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63
           ++LL L  L  LLL L  R      +LPPGPRPL +LGNLL +  + +L S  +  ++YG
Sbjct: 4   SVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYG 63

Query: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123
            ++TVHLGPR VV+L G +A++EALVD+ E FSGRG       F +G G+ F++G+RWKV
Sbjct: 64  DVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKV 123

Query: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
           LR+FS+  +R+FGMGKRS+EERI EE   L+ ELRK++G   DPTF+     +NIICS++
Sbjct: 124 LRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIV 183

Query: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
           FG RF Y D+  L ++ L    F ++SS +G+L+++F   L + PG H+++++N + +  
Sbjct: 184 FGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINA 243

Query: 244 LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303
            I HSV  H+ +LDP +P+D I  +L  M +EK +  S F    L + T +L F GT+T 
Sbjct: 244 YIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETT 303

Query: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADII 363
           STTL + FL ++KYP V  RV  EI+ V+G  R P L DRA MPYT+AVI+E+QRF+D++
Sbjct: 304 STTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLL 363

Query: 364 PMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKS 423
           PM +PH VT+ T+FRG++IPK T+V  +L+T  +DP  F  P  FNP+HFLDAN + KK+
Sbjct: 364 PMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKT 423

Query: 424 PAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRP 483
            AF+PFS G+R+CLGE +AR ELFL+ T ILQ+FS+    APEDIDLTP   G+G +P  
Sbjct: 424 EAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPT 483

Query: 484 FQLCLRPR 491
           +Q+   PR
Sbjct: 484 YQIRFLPR 491


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  440 bits (1131), Expect = e-123
 Identities = 230/495 (46%), Positives = 324/495 (65%), Gaps = 6/495 (1%)

Query: 1   MDSISTAILLLLLALVCLLLTLS---SRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTK 57
           M++  T  LLL LAL+ LLLTL+   +R +G LPPGP PL +LGNLL L    + + L +
Sbjct: 1   MEATGTWALLLALALL-LLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMR 59

Query: 58  LSKEYGSMYTVHLGP-RRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116
           LSK+YG ++T++LGP R VVVL G +AV+EAL  Q EEFSGRG          G+G+ FS
Sbjct: 60  LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFS 119

Query: 117 SGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVS 176
           +G+RW+ LR+F++  LR+ GMGKR  EE I  E   L+   + TEG PFDP+ +L+++ S
Sbjct: 120 NGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATS 179

Query: 177 NIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQ 236
           N++CS+LFG RF Y+D+    ++R        +SS  G+ Y++F   L  +PGPH+++  
Sbjct: 180 NVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLH 239

Query: 237 NFKCLRDLIAHSVHDHQASLDPRSP-RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNL 295
           +   L       V  HQ +LD   P RD +  FL KMA+E+++P + F    +LMT   L
Sbjct: 240 HVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYL 299

Query: 296 LFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHE 355
           LF GT TVSTT+ +  L LMKYP VQ  V+EE++  +G  + P+L DR  +PYTDAV+HE
Sbjct: 300 LFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHE 359

Query: 356 VQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD 415
            QR   ++PM +P  + R T FRG+ +P+GT+V  LL ++ +DP+ F  P+EFNP+ FLD
Sbjct: 360 AQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLD 419

Query: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSS 475
           A+  F+K  AF+PFS G+R+CLGE LA+ ELFL+ T ILQ+FSL+    P+ + L P  S
Sbjct: 420 ADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVS 479

Query: 476 GLGNLPRPFQLCLRP 490
           GL N+P  FQL +RP
Sbjct: 480 GLFNIPPAFQLQVRP 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  415 bits (1067), Expect = e-116
 Identities = 213/485 (43%), Positives = 301/485 (62%), Gaps = 51/485 (10%)

Query: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66
           A+L  L  +V + +    + +GKLPPGP PL  +GN L L ++ +  S+ K+S+      
Sbjct: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ------ 63

Query: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126
                                                        G+AFS+G+R K L +
Sbjct: 64  ---------------------------------------------GVAFSNGERAKQLLR 78

Query: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
           F+I  LR+FG+GKR IEERI EE  FL+  +R T G   DPTF LSR+VSN+I S++FG 
Sbjct: 79  FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 138

Query: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246
           RFDY+D+  L+++ ++   FQ  S+  G+LY++F S++  +PGP Q+ F+  + L D IA
Sbjct: 139 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 198

Query: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306
             V  +Q +LDP SP+DFI  FL  M EE+++P + F++  L+M+T NL   GT+TVSTT
Sbjct: 199 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 258

Query: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DR  MPY +AVIHE+QRF D+IPM+
Sbjct: 259 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 318

Query: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFLD    FKKS AF
Sbjct: 319 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 378

Query: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P       +PR + +
Sbjct: 379 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 438

Query: 487 CLRPR 491
              PR
Sbjct: 439 SFLPR 443


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  395 bits (1014), Expect = e-110
 Identities = 200/485 (41%), Positives = 301/485 (62%), Gaps = 8/485 (1%)

Query: 11  LLLALVCLLLT---LSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67
           LLL  V  LL    L  R     PPGP  L  LGN  L+  +     +    K+YG++++
Sbjct: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80

Query: 68  VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQF 127
           + LG    V+++G   +KEAL+   + F  R   P   +  K NG+  SSG  WK  R+F
Sbjct: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140

Query: 128 SIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSR 187
           ++  LRNFG+GK+S+EERI EE   L   +++  G+PFDP F ++ +VSNIICS+ FG R
Sbjct: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

Query: 188 FDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAH 247
           F+Y D     +++L+++   + +S   +LY++FP ++ ++PGPHQ +F N+K L+  ++H
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260

Query: 248 SVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTL 307
            +  H+   +P   RDFI  +L +M++   +P S FH + L+ +T +L F GT+T STTL
Sbjct: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 308 HHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNL 367
             A L +  YP++Q +VQ EID V+G+ + P+   R +MPYT+AVIHEVQR  +IIP+N+
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 368 PHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFM 427
           P  VT DT   G+ +PKGT ++T L  +H DP+++ TP  FNP+HFL+ N  FKK  AFM
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKKREAFM 439

Query: 428 PFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLT-PLSSGLGNLPRPFQL 486
           PFS G+R CLGE LAR ELF++ T+++Q F+ +P   P +  L+     G+   P   +L
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRP---PNNEKLSLKFRMGITISPVSHRL 496

Query: 487 CLRPR 491
           C  P+
Sbjct: 497 CAVPQ 501


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  331 bits (848), Expect = 1e-90
 Identities = 196/492 (39%), Positives = 292/492 (59%), Gaps = 14/492 (2%)

Query: 8   ILLLLLALVCL--LLTLSSRDKG---KLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEY 62
           +LLL L L+ L  LL   ++D     + PPGPRPL ++GNL LL       SL +LS+ Y
Sbjct: 4   LLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERY 63

Query: 63  GSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWK 122
           G ++TVHLG ++ VVL+G++AVKEAL   G+E + R     F    +G GI FSSG RW+
Sbjct: 64  GPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWR 123

Query: 123 VLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSV 182
             RQF+++ L + G+G+  + ++IL+E   L  +L    G PF P  +L  + SNI  ++
Sbjct: 124 AARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFAL 182

Query: 183 LFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLR 242
           LFG RFDY D   ++++ LI++   ++ SP  +L++++P  L  +   H+ + +  + +R
Sbjct: 183 LFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYP-WLGALLQLHRPVLRKIEEVR 241

Query: 243 DLIAHSVHDHQASLDPRSP-RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTK 301
            ++   +   +  + P  P   ++   + +   + +DP   F     +  T +++  GT+
Sbjct: 242 AILRTLLEARRPHVCPGDPVCSYVDALIQQ--GQGDDPEGLFAEANAVACTLDMVMAGTE 299

Query: 302 TVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFAD 361
           T S TL  A L + ++P VQ RVQEE+D V+G  R P L+D+ A+PYT AV+HEVQRF  
Sbjct: 300 TTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFIT 359

Query: 362 IIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFK 421
           ++P ++P     DT   GFL+PKGT VI LL +V  D +Q+ TP +FNP HFLDAN  F 
Sbjct: 360 LLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFV 418

Query: 422 KSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG--APEDIDLTPLSSGLGN 479
           K  AF+PFSAGRR+C+GE LAR ELFL    +LQ + L P    +P  +D TP +     
Sbjct: 419 KREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFTM 477

Query: 480 LPRPFQLCLRPR 491
            PR   LC  PR
Sbjct: 478 RPRAQALCAVPR 489


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  329 bits (844), Expect = 3e-90
 Identities = 195/497 (39%), Positives = 284/497 (57%), Gaps = 15/497 (3%)

Query: 4   ISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63
           +  A+++ +  L+  L+    R   + PPGP PL  LGNLL +  Q+      +L + +G
Sbjct: 7   VPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66

Query: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPA--FFNF-TKGNGIAFSS-GD 119
            ++++ L    VVVL+G  AV+EALV  GE+ + R   P      F  +  G+  +  G 
Sbjct: 67  DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGP 126

Query: 120 RWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNII 179
            W+  R+FS+  LRN G+GK+S+E+ + EE + L A      G PF P  +L ++VSN+I
Sbjct: 127 AWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVI 186

Query: 180 CSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFK 239
            S+  G RF+YDD R L ++ L  +  +  S    E+ +  P LL  +P    ++ +  K
Sbjct: 187 ASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQK 245

Query: 240 CLRDLIAHSVHDHQASLDP-RSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFG 298
                +   + +H+ + DP + PRD  + FL +M + K +P S F+ + L +   +L   
Sbjct: 246 AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSA 305

Query: 299 GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQR 358
           G  T STTL    L ++ +P VQ RVQ+EID V+G+ R P + D+A MPYT AVIHEVQR
Sbjct: 306 GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR 365

Query: 359 FADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQ 418
           F DI+P+ + H  +RD   +GF IPKGT +IT L++V  D + +  P  F+PEHFLDA  
Sbjct: 366 FGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425

Query: 419 SFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQ-PLGAPEDIDLTPLSSGL 477
            F K  AF+PFSAGRR CLGE LARMELFL+ T++LQ FS   P G P      P   G+
Sbjct: 426 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGV 480

Query: 478 GNL---PRPFQLCLRPR 491
                 P P++LC  PR
Sbjct: 481 FAFLVTPSPYELCAVPR 497


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  327 bits (839), Expect = 1e-89
 Identities = 187/494 (37%), Positives = 278/494 (56%), Gaps = 10/494 (2%)

Query: 3   SISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTS--LTKLSK 60
           ++  A+ LLL AL    L    R  G  PPGP  L  +GN+  L +   L    + K S+
Sbjct: 13  ALGGALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71

Query: 61  EYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSS-GD 119
            YG ++++ LG    VVL+GY  VKE LV Q E F+ R   P F   TK  G+  S  G 
Sbjct: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR 131

Query: 120 RWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNII 179
            W   R+ ++   R FG G++S E +ILEE  F    +   +G PFD   +++ +VSNI 
Sbjct: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191

Query: 180 CSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFK 239
             ++FG RF Y+D     +I L ++N ++ +S    LY+ FP +     G HQ++F+N  
Sbjct: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251

Query: 240 CLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGG 299
            + D ++  +     +  P+ P+ F+  +L +M + K DP S F  + L+ +   L+  G
Sbjct: 252 VVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAG 311

Query: 300 TKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRF 359
           T+T +  L  A L +  YP +Q +VQ+EIDL++G    P+  D+  MPYT+AV+HEV RF
Sbjct: 312 TETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRF 371

Query: 360 ADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQS 419
            +I+P+ + H  + D   RG+ IPKGT VIT L +VH+D   +  P+ F+PE FLD++  
Sbjct: 372 CNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGY 431

Query: 420 FKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDI--DLTPLSSGL 477
           F K  A +PFS GRR CLGE LARME+FL+ TA+LQ F L     P ++  DL P   G+
Sbjct: 432 FAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH---FPHELVPDLKP-RLGM 487

Query: 478 GNLPRPFQLCLRPR 491
              P+P+ +C   R
Sbjct: 488 TLQPQPYLICAERR 501


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  303 bits (777), Expect = 2e-82
 Identities = 190/511 (37%), Positives = 279/511 (54%), Gaps = 32/511 (6%)

Query: 10  LLLLALVCLL--LTLSSRDKGKLPPGPRPLSILGN---LLL---LCSQDMLTSLTK---- 57
           LLL  LV LL    L  R    +PPGP P  ++GN   +LL   L  +  L+S T+    
Sbjct: 37  LLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96

Query: 58  -------------LSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAF 104
                        L++ YGS+++  +G   VVVLS + +V+EALV Q E FS R   P  
Sbjct: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156

Query: 105 FNFTKGNGIAFSS-GDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGE 163
              TK  G+ F+  G  W+  R+FS   LR+FG+GK S+E +I+EE  ++ AE++K   +
Sbjct: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216

Query: 164 PFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSL 223
           PF P  ++S +VSNIICS+ FG RFDY +     ++  ++   +I  +    L +I P L
Sbjct: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276

Query: 224 LDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEE-KEDPLSH 282
                GP + + Q  K +   +   + DHQ SLD  +P+DFI  +L  M EE K +  S 
Sbjct: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336

Query: 283 FHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKD 342
           F  + L     +L   GT T + +L    L +   P VQ +V EEI+ V+G  R P+L D
Sbjct: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396

Query: 343 RAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQF 402
           +A MPYT+A I EVQR   ++P+ +PH  + +T  +G+ IPKGT ++  L +VH DP+ +
Sbjct: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 403 LTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPL 462
             P++F P  FLD      K   F+PF  G+R+C+GE LA+MELFL   +++QSF+    
Sbjct: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFA---F 513

Query: 463 GAPEDIDLTPLSS--GLGNLPRPFQLCLRPR 491
             PED     L+   GL   P PF + +  R
Sbjct: 514 ALPEDSKKPLLTGRFGLTLAPHPFNITISRR 544


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  286 bits (731), Expect = 4e-77
 Identities = 181/493 (36%), Positives = 260/493 (52%), Gaps = 58/493 (11%)

Query: 4   ISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYG 63
           +  A+++ +  L+  L+    R   + PPGP PL  LGNLL +  Q+      +L + +G
Sbjct: 7   VPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66

Query: 64  SMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKV 123
            ++++ L    VVVL+G  AV+EALV  GE+ + R   P                     
Sbjct: 67  DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVP--------------------- 105

Query: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
                  I +  G G RS                   +G PF P  +L ++VSN+I S+ 
Sbjct: 106 -------ITQILGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLT 139

Query: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
            G RF+YDD R L ++ L  +  +  S    E+ +  P LL  +P    ++ +  K    
Sbjct: 140 CGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH-IPALAGKVLRFQKAFLT 198

Query: 244 LIAHSVHDHQASLDP-RSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKT 302
            +   + +H+ + DP + PRD  + FL +M + K +P S F+ + L +   +L   G  T
Sbjct: 199 QLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVT 258

Query: 303 VSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADI 362
            STTL    L ++ +P VQ RVQ+EID V+G+ R P + D+A MPYT AVIHEVQRF DI
Sbjct: 259 TSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDI 318

Query: 363 IPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKK 422
           +P+ + H  +RD   +GF IPKGT +IT L++V  D + +  P  F+PEHFLDA   F K
Sbjct: 319 VPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVK 378

Query: 423 SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQ-PLGAPEDIDLTPLSSGLGNL- 480
             AF+PFSAGRR CLGE LARMELFL+ T++LQ FS   P G P      P   G+    
Sbjct: 379 PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFL 433

Query: 481 --PRPFQLCLRPR 491
             P P++LC  PR
Sbjct: 434 VTPSPYELCAVPR 446


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  244 bits (624), Expect = 1e-64
 Identities = 114/217 (52%), Positives = 161/217 (74%)

Query: 274 EEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG 333
           +EK +  S F +++L+ T  ++   GT+T STTL +  L L+KYP+V A+VQEEI+ VVG
Sbjct: 214 QEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 273

Query: 334 RARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLN 393
           R R P ++DR+ MPYTDAV+HE+QR+ D++P NLPH VT D  F+ +LIPKGT +IT L 
Sbjct: 274 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 333

Query: 394 TVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAI 453
           +V ++  +F  P+ F+P HFLD + +FKKS  FMPFSAG+R+C+GE LARMELFL+LT I
Sbjct: 334 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 393

Query: 454 LQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRP 490
           LQ+F+L+    P+DID+TP+++  G +P  +QLC  P
Sbjct: 394 LQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIP 430



 Score =  226 bits (577), Expect = 3e-59
 Identities = 111/209 (53%), Positives = 144/209 (68%)

Query: 5   STAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGS 64
           + A++L L  L  L L   S  +G+LP GP PL I+GN+L L  +DM  SLT  SK YG 
Sbjct: 4   AVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGP 63

Query: 65  MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVL 124
           ++TV+ G + +VVL GY+AVKEAL+D GEEFSGRG +P      KG GI FS+G RWK +
Sbjct: 64  VFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEI 123

Query: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLF 184
           R+F +  LRNFGMGKRSIE+R+ EE   L+ ELRKT   P DPTF+L  +  N+ICSV+F
Sbjct: 124 RRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIF 183

Query: 185 GSRFDYDDERLLTIIRLINDNFQIMSSPW 213
             RFDY D+R L ++   N+N +I+SSPW
Sbjct: 184 HDRFDYKDQRFLNLMEKFNENLRILSSPW 212


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  241 bits (615), Expect = 1e-63
 Identities = 157/495 (31%), Positives = 270/495 (54%), Gaps = 31/495 (6%)

Query: 3   SISTAILLLLLALVCLLLTL--SSRD---KG-KLPPGPRPLSILGNLLLLCSQDMLTSLT 56
           S+S    LL   + CL+  +  +SR    KG K PPGP    ++G++L L     L +L+
Sbjct: 6   SMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL-ALS 64

Query: 57  KLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116
           ++S++YG +  + +G   VVVLSG   +++ALV QG++F GR D   F   + G  ++FS
Sbjct: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124

Query: 117 --SGDRWKVLRQFSIQILRNFGMGKRS-------IEERILEEGSFLLAELRKTEGEP--F 165
             SG  W   R+ +   L++F +           +EE + +E   L++ L++    P  F
Sbjct: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184

Query: 166 DPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLD 225
           +P   +  SV+N+IC++ FG R+D++ + LL+++ L N+  +++ S  G   D  P +L 
Sbjct: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS--GNPADFIP-ILR 241

Query: 226 WVPGPHQRIFQNF-KCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFH 284
           ++P P    F++  +     +   V +H  + +    RD     +    E++ D  ++  
Sbjct: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301

Query: 285 M--DTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKD 342
           +  + ++    +L   G  TV+T +  + + L+  P+VQ ++QEE+D V+GR+R P L D
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361

Query: 343 RAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQF 402
           R+ +PY +A I E  R +  +P  +PH  TRDT+ +GF IPKG  V      +++D   +
Sbjct: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421

Query: 403 LTPQEFNPEHFLDANQSFKK--SPAFMPFSAGRRLCLGESLARMELFLYLTAILQ--SFS 458
           + P EF PE FL  + +  K  S   + F  G+R C+GE++AR E+FL+L  +LQ   FS
Sbjct: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481

Query: 459 LQPLGAPEDIDLTPL 473
           + PLG    +D+TP+
Sbjct: 482 V-PLGV--KVDMTPI 493


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  224 bits (572), Expect = 1e-58
 Identities = 156/509 (30%), Positives = 260/509 (51%), Gaps = 32/509 (6%)

Query: 3   SISTAILLLLLALVCL------LLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLT 56
           SI    LLLLL+++        LL    R     PPGP    ++GN   +  Q    S  
Sbjct: 17  SIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAV-GQAAHLSFA 75

Query: 57  KLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116
           +L++ YG ++ + LG   +VVL+G +A+ +ALV QG  F+ R  + +F   + G  +AF 
Sbjct: 76  RLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFG 135

Query: 117 S-GDRWKVLRQFSIQILRNF----GMGKRSIEERILEEGSFLLAELRK--TEGEPFDPTF 169
              + WKV R+ +  ++RNF       ++ +E  +L E   L+A L +   +G   DP  
Sbjct: 136 HYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRP 195

Query: 170 VLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPG 229
           +   +V+N++ +V FG R+ +DD     ++    +  + + +  G L D+ P  L + P 
Sbjct: 196 LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQYFPN 252

Query: 230 PHQRIFQNFKCLRDLIAHSVHD----HQASLDP-RSPRDFIQCFLTKMAEEKEDPLSH-- 282
           P + +F+ F+ L    ++ + D    H  SL P  +PRD +  F+   AE+K    SH  
Sbjct: 253 PVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILS-AEKKAAGDSHGG 311

Query: 283 ---FHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPA 339
                ++ +  T  ++      T+ST L    L   +YP VQ RVQ E+D VVGR RLP 
Sbjct: 312 GARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPC 371

Query: 340 LKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDP 399
           + D+  +PY  A ++E  RF+  +P+ +PH  T +T+  G+ IPK T V     +V++DP
Sbjct: 372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431

Query: 400 SQFLTPQEFNPEHFLDANQSFKK--SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSF 457
            ++  P+ F+P  FLD +    K  +   M FS G+R C+GE L++M+LFL+++ +    
Sbjct: 432 LKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 491

Query: 458 SLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486
             +    P +      S GL   P+ F++
Sbjct: 492 DFR--ANPNEPAKMNFSYGLTIKPKSFKV 518


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  218 bits (554), Expect = 1e-56
 Identities = 152/495 (30%), Positives = 242/495 (48%), Gaps = 36/495 (7%)

Query: 5   STAILLLLLALVCLLLTLSSR-----DKG-KLPPGPRPLSILGNLLLLCSQDMLTSLTKL 58
           S   LLL  A+ CL+  +         KG K PP P    +LG++L L     L +L+++
Sbjct: 10  SATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHL-ALSRM 68

Query: 59  SKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS-- 116
           S+ YG +  + +G   V+VLS    +++ALV QG++F GR D       T G  + FS  
Sbjct: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128

Query: 117 SGDRWKVLRQFSIQILRNFGMGKRS-------IEERILEEGSFLLAELRKTEGEP--FDP 167
           SG  W   R+ +   L  F +           +EE + +E   L++ L++    P  FDP
Sbjct: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188

Query: 168 TFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWV 227
              +  SV+N+I ++ FG  F    + +L++++  ++  +  SS  G   D FP +L ++
Sbjct: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFP-ILRYL 245

Query: 228 PGPHQRIFQNFKCLRD----LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHF 283
           P P     Q FK         +  +V +H    D  S RD          +      +  
Sbjct: 246 PNP---ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLI 302

Query: 284 HMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDR 343
             + ++   +++   G  TV+T +  + + L+  P++Q ++Q+E+D V+GR R P L DR
Sbjct: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362

Query: 344 AAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFL 403
             +PY +A I E  R +  +P  +PH  TRDT   GF IPK   V      V++DP  + 
Sbjct: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422

Query: 404 TPQEFNPEHFLDANQSFKKSP---AFMPFSAGRRLCLGESLARMELFLYLTAILQ--SFS 458
            P EF PE FL A+ +    P     M F  G+R C+GE LA+ E+FL+L  +LQ   FS
Sbjct: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482

Query: 459 LQPLGAPEDIDLTPL 473
           + P      +DLTP+
Sbjct: 483 VPP---GVKVDLTPI 494


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  192 bits (487), Expect = 8e-49
 Identities = 158/500 (31%), Positives = 249/500 (49%), Gaps = 39/500 (7%)

Query: 8   ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67
           +LL LLA   LL          LPP      +    L L   D+   L  L++++G +Y 
Sbjct: 8   LLLPLLAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYR 61

Query: 68  VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR---WKVL 124
           +HLG + VVVL+  + ++EA+V +  +F+GR + P  +     N    S GD    WK  
Sbjct: 62  LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWKAH 120

Query: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAE-LRKTEGEPFDPTFVLSRSVSNIICSVL 183
           ++ +   L    +G R   E ++E+ +    E +R   G P       S    +IIC + 
Sbjct: 121 KKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLT 177

Query: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
           FG +   DD  +    + I +  +  S    ++ D+ P  L + P P  R  +     RD
Sbjct: 178 FGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRD 235

Query: 244 -LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLS------HFHMDTLLMTTHNLL 296
            ++   +  H+ SL     RD +   L  +A+   +  S      H HM  +     +LL
Sbjct: 236 HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV-----DLL 290

Query: 297 FGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG----RARLPALKDRAAMPYTDAV 352
            GGT+T + TL  A + L+ +P++Q R+QEE+D  +G     +R+P  KDRA +P  +A 
Sbjct: 291 IGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNAT 349

Query: 353 IHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEH 412
           I EV R   ++P+ LPHR TR ++  G+ IP+GT +I  L   H D + +  P EF P+ 
Sbjct: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409

Query: 413 FLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG-APEDIDLT 471
           FL+      K+   + F  G R+CLGE LAR+ELF+ LT +LQ+F+L P G A   +   
Sbjct: 410 FLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPL 465

Query: 472 PLSSGLGNLPRPFQLCLRPR 491
           P  S +  + +PFQ+ L+PR
Sbjct: 466 PHCSVILKM-QPFQVRLQPR 484


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  190 bits (482), Expect = 3e-48
 Identities = 142/478 (29%), Positives = 236/478 (49%), Gaps = 18/478 (3%)

Query: 8   ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQD-MLTSLTKLSKEYGSMY 66
           + LLLL L  L          K P     L ++G+L  L     M  +  KL K+YG +Y
Sbjct: 5   VALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIY 64

Query: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGN--GIAFS-SGDRWKV 123
           +V +G +  V++  +Q  KE L+ +G++FSGR    A  +    N  GIAF+ SG  W++
Sbjct: 65  SVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQM-ATLDIASNNRKGIAFADSGAHWQL 123

Query: 124 LRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVL 183
            R+ ++     F  G + +E+ I +E S L   L    G+  D +F +  +V+N+I  + 
Sbjct: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183

Query: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
           F + +   D  L  +I+  N+   I +     L D+ P L  +     +++  + K   D
Sbjct: 184 FNTSYKNGDPEL-NVIQNYNEGI-IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241

Query: 244 LIAHSVHDHQASLDPRSPRDFIQCFL-TKMAEEK----EDPLSHFHMDTLLMTTHNLLFG 298
           L+   + +++      S  + +   +  KM  +      D  S    D  ++TT   +FG
Sbjct: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301

Query: 299 -GTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQ 357
            G +T ++ +      L+  P+V+ ++ EEID  VG +R P + DR  +   +A I EV 
Sbjct: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361

Query: 358 RFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD-- 415
           R   + PM +PH+   D++   F + KGT+VI  L  +H++  ++  P +F PE FL+  
Sbjct: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421

Query: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPL 473
             Q    S +++PF AG R C+GE LAR ELFL +  +LQ F L+    P+D  L  L
Sbjct: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE---VPDDGQLPSL 476


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  166 bits (419), Expect = 6e-41
 Identities = 148/497 (29%), Positives = 232/497 (46%), Gaps = 63/497 (12%)

Query: 8   ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67
           +LL LLA   LL          LPP      +    L L   D+   L  L++++G +Y 
Sbjct: 8   LLLPLLAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYR 61

Query: 68  VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQF 127
           +HLG            +++ LV +       GDY                   WK  ++ 
Sbjct: 62  LHLG------------LQDKLVSRNYPDLSLGDYSLL----------------WKAHKKL 93

Query: 128 SIQILRNFGMGKRSIEERILEEGSFLLAE-LRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
           +   L    +G R   E ++E+ +    E +R   G P       S    +IIC + FG 
Sbjct: 94  TRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 150

Query: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD-LI 245
           +   DD  +    + I +  +  S    ++ D+ P  L + P P  R  +     RD ++
Sbjct: 151 KIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIV 208

Query: 246 AHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLS------HFHMDTLLMTTHNLLFGG 299
              +  H+ SL     RD +   L  +A+   +  S      H HM  +     +LL GG
Sbjct: 209 EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV-----DLLIGG 263

Query: 300 TKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG----RARLPALKDRAAMPYTDAVIHE 355
           T+T + TL  A + L+ +P++Q R+QEE+D  +G     +R+P  KDRA +P  +A I E
Sbjct: 264 TETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAE 322

Query: 356 VQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD 415
           V R   ++P+ LPHR TR ++  G+ IP+GT +I  L   H D + +  P EF P+ FL+
Sbjct: 323 VLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 382

Query: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG-APEDIDLTPLS 474
                 K+   + F  G R+CLGE LAR+ELF+ LT +LQ+F+L P G A   +   P  
Sbjct: 383 PG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHC 438

Query: 475 SGLGNLPRPFQLCLRPR 491
           S +  + +PFQ+ L+PR
Sbjct: 439 SVILKM-QPFQVRLQPR 454


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  125 bits (313), Expect = 1e-28
 Identities = 137/495 (27%), Positives = 217/495 (43%), Gaps = 42/495 (8%)

Query: 9   LLLLLALVCLLL--TLSSRDKGKLP-PGPRPLSILGNLLL----LCSQDMLTSLTKLSKE 61
           LLL ++LV L L  T S     KL  PGP PL  LGN+L      C  DM     +  K+
Sbjct: 13  LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDM-----ECHKK 67

Query: 62  YGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEE-FSGRGDYPAFFNFTKGNGIAFSSGDR 120
           YG ++  + G + V+ ++    +K  LV +    F+ R  +     F K + I+ +  + 
Sbjct: 68  YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV-GFMK-SAISIAEDEE 125

Query: 121 WKVLRQFSIQILRNFGMGK-RSIEERILEEGSFLLAELRKTE--GEPFDPTFVLSRSVSN 177
           WK LR     +   F  GK + +   I + G  L+  LR+    G+P     V      +
Sbjct: 126 WKRLRSL---LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182

Query: 178 IICSVLFGSRFDY----DDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQR 233
           +I S  FG   D      D  +    +L+  +F     P+     +FP L+  +   +  
Sbjct: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL---DPFFLSITVFPFLIPILEVLNIC 239

Query: 234 IFQNFKCLRDLIAHSVHDHQASL--DPRSPR-DFIQCFLTKMAEEKEDPLSHFHMDTLLM 290
           +F   + + + +  SV   + S   D +  R DF+Q  +   ++  ++  SH  +  L +
Sbjct: 240 VFP--REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID--SQNSKETESHKALSDLEL 295

Query: 291 TTHNLLF--GGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPY 348
              +++F   G +T S+ L      L  +P VQ ++QEEID V+     P       M Y
Sbjct: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355

Query: 349 TDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEF 408
            D V++E  R   I  M L     +D    G  IPKG  V+     +H DP  +  P++F
Sbjct: 356 LDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414

Query: 409 NPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDI 468
            PE F   N+       + PF +G R C+G   A M + L L  +LQ+FS +P    +  
Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ-- 472

Query: 469 DLTPLSSGLGNLPRP 483
              PL   LG L +P
Sbjct: 473 --IPLKLSLGGLLQP 485


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  120 bits (301), Expect = 3e-27
 Identities = 113/468 (24%), Positives = 205/468 (43%), Gaps = 43/468 (9%)

Query: 30  LPPGPRPLSILGNLLLLC--SQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEA 87
           +P   R   ++G+ LL+    ++    + + ++EY  M  + L    V +++ Y A    
Sbjct: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE 109

Query: 88  LVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ-----FSIQILRNFGMGKRSI 142
           ++    +   +     F     G G+  S+G++W+  R+     F   IL +F       
Sbjct: 110 VILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDF------- 162

Query: 143 EERILEEGSFLLAELRK-TEGEPFDPTFVLSRSVSNIICSVLFGSRF----DYDDERLLT 197
            + + E+ + L+ +L K    E F+  F ++    +IIC    G       + D E +  
Sbjct: 163 LDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRA 222

Query: 198 IIRLINDNFQIMSSPWGEL---YDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQA 254
           + R+    F+ +  PW  L   Y +F     W      +I   F     +IA   ++  A
Sbjct: 223 VYRMSEMIFRRIKMPWLWLDLWYLMFKE--GWEHKKSLQILHTFT--NSVIAERANEMNA 278

Query: 255 SLDPRSP-----------RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303
           + D R             R F+   L+ + +++ + LSH   + +       +F G  T 
Sbjct: 279 NEDCRGDGRGSAPSKNKRRAFLDLLLS-VTDDEGNRLSH---EDIREEVDTFMFEGHDTT 334

Query: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPA-LKDRAAMPYTDAVIHEVQRFADI 362
           +  ++ +   L   P+VQ +V  E+D V G++  PA ++D   + Y + VI E  R    
Sbjct: 335 AAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPS 394

Query: 363 IPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKK 422
           +P+     V+ D    G+ + KGT+ + +   +H DP  F  P+EF PE F   N   + 
Sbjct: 395 VPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRH 453

Query: 423 SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDL 470
             A++PFSAG R C+G+  A ME    L+ IL+ F ++     E++ L
Sbjct: 454 PYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGL 501


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  118 bits (295), Expect = 1e-26
 Identities = 119/468 (25%), Positives = 198/468 (42%), Gaps = 30/468 (6%)

Query: 10  LLLLALVCLLLTLSSRDKGKLP----PGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSM 65
           LLL   + LL    +R  G       PGP PL +LGN+L    Q +    T+  K+YG M
Sbjct: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKM 71

Query: 66  YTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLR 125
           +  + G   V+ ++    ++  LV +               F K + I+ +  + WK +R
Sbjct: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK-SAISLAEDEEWKRIR 130

Query: 126 QFSIQILRNFGMGK-RSIEERILEEGSFLLAELRKT--EGEPFDPTFVLSRSVSNIICSV 182
                +   F  GK + +   I + G  L+  LR+   +G+P     +      ++I   
Sbjct: 131 SL---LSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187

Query: 183 LFGSRFDY----DDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNF 238
            FG   D      D  + +  + +   F     P      +FP L       +  +F   
Sbjct: 188 SFGVNIDSLNNPQDPFVESTKKFLKFGFL---DPLFLSIILFPFLTPVFEALNVSLFP-- 242

Query: 239 KCLRDLIAHSVHDHQASL--DPRSPR-DFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNL 295
           K   + ++ SV+  + S   D +  R DF+Q  +   ++  ++  SH  +  L +   ++
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMID--SQNSKETESHKALSDLELAAQSI 300

Query: 296 LF--GGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVI 353
           +F   G +T S+ L      L  +P VQ ++Q+EID V+     P       M Y D V+
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 354 HEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHF 413
           +E  R   +  + L     +D    G  IPKG+ V+     +H+DP  +  P+EF PE F
Sbjct: 361 NETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419

Query: 414 LDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQP 461
                S      + PF  G R C+G   A M + L L  +LQ+FS +P
Sbjct: 420 SKKKDSIDPY-IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  112 bits (280), Expect = 8e-25
 Identities = 118/468 (25%), Positives = 200/468 (42%), Gaps = 30/468 (6%)

Query: 11  LLLALVCLLLTL-SSRDKGKLP----PGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSM 65
           LLLA+  +LL L  +R  G       PGP PL  LGN L    +   T   +  K+Y  +
Sbjct: 13  LLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSF-RKGYWTFDMECYKKYRKV 71

Query: 66  YTVHLGPRRVVVLSGYQAVKEALVDQGEE-FSGRGDYPAFFNFTKGNGIAFSSGDRWKVL 124
           + ++   + ++ ++    +K  LV +    F+ R  +     F K N I+ +  + WK +
Sbjct: 72  WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPV-GFMK-NAISIAEDEEWKRI 129

Query: 125 RQFSIQILRNFGMGK-RSIEERILEEGSFLLAELRKTE--GEPFDPTFVLSRSVSNIICS 181
           R     +   F  GK + +   I + G  L+  LR+    G+P     V      ++I S
Sbjct: 130 RSL---LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186

Query: 182 VLFGSRFDY----DDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQN 237
             FG   D      D  +    +L+  N      P+     +FP L   +   +  +F  
Sbjct: 187 TSFGVSIDSLNNPQDPFVENTKKLLRFN---PLDPFVLSIKVFPFLTPILEALNITVFPR 243

Query: 238 FKCLRDLI--AHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNL 295
            K +  L      + + +     +   DF+Q  +   ++  +D  +H  +  L +   ++
Sbjct: 244 -KVISFLTKSVKQIKEGRLKETQKHRVDFLQLMID--SQNSKDSETHKALSDLELMAQSI 300

Query: 296 LF--GGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVI 353
           +F   G +T S+ L      L  +P VQ +VQ+EID V+     P       + Y D V+
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360

Query: 354 HEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHF 413
           +E  R   +  M L     +D    G  IPKG  V+     +H+DP  +  P++F PE F
Sbjct: 361 NETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERF 419

Query: 414 LDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQP 461
              N+       + PF +G R C+G   A + + L L  +LQ+FS +P
Sbjct: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  107 bits (267), Expect = 2e-23
 Identities = 109/445 (24%), Positives = 188/445 (42%), Gaps = 31/445 (6%)

Query: 32  PGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQ 91
           PGP PL  LG +L    + +     + +++YG M+ ++ G + ++V+     +K  LV +
Sbjct: 39  PGPTPLPFLGTILFYL-RGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 92  GEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGS 151
                          F K + ++F+  + WK +R        +     + +   I + G 
Sbjct: 98  CYSVFTNQMPLGPMGFLK-SALSFAEDEEWKRIRTLLSPAFTSVKF--KEMVPIISQCGD 154

Query: 152 FLLAELRKT--EGEPFDPTFVLSRSVSNIICSVLFGSRFDY----DDERLLTIIRLINDN 205
            L+  LR+     +  +          ++I   LFG   D      D  L  + +L+  +
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 206 FQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASL--DPRSPR- 262
           F     P+  L  +FP L       +  +F   K +   + +S+   + S   D +  R 
Sbjct: 215 FL---DPFLLLISLFPFLTPVFEALNIGLFP--KDVTHFLKNSIERMKESRLKDKQKHRV 269

Query: 263 DFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLL--FGGTKTVSTTLHHAFLALMKYPKV 320
           DF Q  +   ++  ++  SH  +  L +   +++  F    T STTL      L  +P V
Sbjct: 270 DFFQQMID--SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDV 327

Query: 321 QARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTR----DTA 376
           Q ++QEEID V+             M Y D V++E  R   ++      RVTR    D  
Sbjct: 328 QQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-----RVTRVCKKDIE 382

Query: 377 FRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLC 436
             G  IPKG  V+  +  +H+DP  +  P++F PE F   N+       ++PF AG R C
Sbjct: 383 INGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNC 442

Query: 437 LGESLARMELFLYLTAILQSFSLQP 461
           +G   A   + L +   LQ+FS +P
Sbjct: 443 IGMRFALTNIKLAVIRALQNFSFKP 467


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.140    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,412,423
Number of Sequences: 37866
Number of extensions: 889349
Number of successful extensions: 2393
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2216
Number of HSP's gapped (non-prelim): 100
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.