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Search of human proteins with 197209817
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197209817 coiled-coil and C2 domain containing 2A isoform b
[Homo sapiens]
(1512 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197209817 coiled-coil and C2 domain containing 2A isoform b [... 3047 0.0
gi|197209974 coiled-coil and C2 domain containing 2A isoform a [... 2993 0.0
gi|229577352 coiled-coil and C2 domain containing 2B isoform 1 [... 397 e-110
gi|109452583 coiled-coil and C2 domain containing 2B isoform 2 [... 239 1e-62
gi|21314728 centrosomal protein 76kDa [Homo sapiens] 65 5e-10
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|148746195 trichohyalin [Homo sapiens] 49 5e-05
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 48 8e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 47 2e-04
gi|92859701 myosin VI [Homo sapiens] 46 2e-04
gi|110349719 titin isoform N2-A [Homo sapiens] 45 7e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 44 0.001
gi|62198235 drebrin-like isoform b [Homo sapiens] 44 0.001
gi|21361670 drebrin-like isoform a [Homo sapiens] 44 0.001
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 44 0.002
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 44 0.002
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 43 0.002
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 43 0.002
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 43 0.002
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 43 0.002
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 43 0.003
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 43 0.003
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 43 0.003
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 43 0.003
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 42 0.003
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 42 0.004
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 42 0.004
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 42 0.004
>gi|197209817 coiled-coil and C2 domain containing 2A isoform b [Homo
sapiens]
Length = 1512
Score = 3047 bits (7899), Expect = 0.0
Identities = 1512/1512 (100%), Positives = 1512/1512 (100%)
Query: 1 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 60
MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ
Sbjct: 1 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 60
Query: 61 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 120
AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH
Sbjct: 61 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 120
Query: 121 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 180
DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE
Sbjct: 121 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 180
Query: 181 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 240
PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP
Sbjct: 181 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 240
Query: 241 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 300
SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR
Sbjct: 241 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 300
Query: 301 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 360
ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID
Sbjct: 301 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 360
Query: 361 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 420
ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK
Sbjct: 361 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 420
Query: 421 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 480
PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP
Sbjct: 421 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 480
Query: 481 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 540
LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR
Sbjct: 481 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 540
Query: 541 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 600
AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT
Sbjct: 541 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 600
Query: 601 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 660
LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF
Sbjct: 601 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 660
Query: 661 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 720
GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH
Sbjct: 661 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 720
Query: 721 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 780
VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS
Sbjct: 721 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 780
Query: 781 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 840
ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR
Sbjct: 781 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 840
Query: 841 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 900
LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL
Sbjct: 841 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 900
Query: 901 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 960
RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL
Sbjct: 901 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 960
Query: 961 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1020
SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS
Sbjct: 961 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1020
Query: 1021 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1080
SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE
Sbjct: 1021 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1080
Query: 1081 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1140
LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP
Sbjct: 1081 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1140
Query: 1141 FSTIYFQARFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLN 1200
FSTIYFQARFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLN
Sbjct: 1141 FSTIYFQARFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLN 1200
Query: 1201 PPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEH 1260
PPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEH
Sbjct: 1201 PPQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEH 1260
Query: 1261 AVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLK 1320
AVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLK
Sbjct: 1261 AVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLK 1320
Query: 1321 NVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRS 1380
NVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRS
Sbjct: 1321 NVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRS 1380
Query: 1381 DKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRA 1440
DKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRA
Sbjct: 1381 DKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRA 1440
Query: 1441 ELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLS 1500
ELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLS
Sbjct: 1441 ELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLS 1500
Query: 1501 VWIYVASLIRNR 1512
VWIYVASLIRNR
Sbjct: 1501 VWIYVASLIRNR 1512
>gi|197209974 coiled-coil and C2 domain containing 2A isoform a [Homo
sapiens]
Length = 1620
Score = 2993 bits (7759), Expect = 0.0
Identities = 1502/1571 (95%), Positives = 1506/1571 (95%), Gaps = 59/1571 (3%)
Query: 1 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 60
MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ
Sbjct: 50 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 109
Query: 61 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 120
AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH
Sbjct: 110 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 169
Query: 121 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 180
DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE
Sbjct: 170 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 229
Query: 181 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 240
PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP
Sbjct: 230 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 289
Query: 241 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 300
SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR
Sbjct: 290 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 349
Query: 301 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 360
ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID
Sbjct: 350 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 409
Query: 361 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 420
ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK
Sbjct: 410 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 469
Query: 421 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 480
PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP
Sbjct: 470 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 529
Query: 481 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 540
LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR
Sbjct: 530 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 589
Query: 541 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 600
AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT
Sbjct: 590 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 649
Query: 601 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 660
LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF
Sbjct: 650 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 709
Query: 661 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 720
GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH
Sbjct: 710 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 769
Query: 721 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 780
VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS
Sbjct: 770 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 829
Query: 781 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 840
ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR
Sbjct: 830 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 889
Query: 841 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 900
LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL
Sbjct: 890 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 949
Query: 901 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 960
RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL
Sbjct: 950 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 1009
Query: 961 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1020
SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS
Sbjct: 1010 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1069
Query: 1021 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1080
SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE
Sbjct: 1070 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1129
Query: 1081 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1140
LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP
Sbjct: 1130 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1189
Query: 1141 FSTIYFQARFE--------------SQEDEKLLQ-------------------------- 1160
FSTIYFQAR + S+E +L+
Sbjct: 1190 FSTIYFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLV 1249
Query: 1161 ----ATEKF---------------QAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1201
EKF QAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP
Sbjct: 1250 PGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1309
Query: 1202 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1261
PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA
Sbjct: 1310 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1369
Query: 1262 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1321
VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN
Sbjct: 1370 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1429
Query: 1322 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1381
VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD
Sbjct: 1430 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1489
Query: 1382 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1441
KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE
Sbjct: 1490 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1549
Query: 1442 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1501
LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV
Sbjct: 1550 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1609
Query: 1502 WIYVASLIRNR 1512
WIYVASLIRNR
Sbjct: 1610 WIYVASLIRNR 1620
>gi|229577352 coiled-coil and C2 domain containing 2B isoform 1 [Homo
sapiens]
Length = 401
Score = 397 bits (1020), Expect = e-110
Identities = 184/397 (46%), Positives = 264/397 (66%), Gaps = 2/397 (0%)
Query: 1116 EDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARFESQEDEKLLQATEKFQAECALKFPN 1175
ED + H+ I ++WLGC+ PFS + Q+ F Q + +LQ + F+ C FPN
Sbjct: 7 EDHCLKSCSGHSYIRKNWLGCIVFPFSALLQQSEFLDQTE--VLQRAQIFKKNCKAMFPN 64
Query: 1176 RQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLPDTVS 1235
R+ +TTV + G +TRY+K LNPPQ+LL+++ +N AT +L+AR+VSLIPF+P+T
Sbjct: 65 RRIVTTVFNDEGIQFLVTRYIKALNPPQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPD 124
Query: 1236 FGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWE 1295
D+W TS+ + L G++EEHA+LLCN+FL GKKA +L+G ++ EG AYV+T E
Sbjct: 125 ENDGSDIWMTSEHCISLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVVTQE 184
Query: 1296 QGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWK 1355
YL+WNP +G Y QFD FCPLK+V CL N+WFNIQ+ +P+ + FD ++ WK
Sbjct: 185 TNEYLLWNPSTGQCYKQFDPFCPLKSVDCLFDDRNVWFNIQQNNTPMAVFFDYSKESFWK 244
Query: 1356 SFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYC 1415
+++ + S+QPEE+IY +DK+ +L++RIE+ LK K+M+WRP+H T WNR C
Sbjct: 245 QLLPKNVQGTKIQSIQPEEIIYFETDKSMVEDLRNRIERTLKSKVMEWRPKHPTHWNRQC 304
Query: 1416 TSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGV 1475
T LR LP LE G V + E + L Y +GFP+ MPY +V+ +IDAVY TG+
Sbjct: 305 TFILRQILPKLEFGIGSFVSSEGDNEFERILQFYWVTGFPIQMPYIDVQSIIDAVYQTGI 364
Query: 1476 HNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1512
H+ + P EFALAVYIHPYP N+LSVW+Y+ASL++++
Sbjct: 365 HSAEFPQTEFALAVYIHPYPNNILSVWVYLASLVQHQ 401
>gi|109452583 coiled-coil and C2 domain containing 2B isoform 2 [Homo
sapiens]
Length = 322
Score = 239 bits (611), Expect = 1e-62
Identities = 111/256 (43%), Positives = 164/256 (64%), Gaps = 2/256 (0%)
Query: 1116 EDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARFESQEDEKLLQATEKFQAECALKFPN 1175
ED + H+ I ++WLGC+ PFS + Q+ F Q + +LQ + F+ C FPN
Sbjct: 7 EDHCLKSCSGHSYIRKNWLGCIVFPFSALLQQSEFLDQTE--VLQRAQIFKKNCKAMFPN 64
Query: 1176 RQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLPDTVS 1235
R+ +TTV + G +TRY+K LNPPQ+LL+++ +N AT +L+AR+VSLIPF+P+T
Sbjct: 65 RRIVTTVFNDEGIQFLVTRYIKALNPPQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPD 124
Query: 1236 FGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWE 1295
D+W TS+ + L G++EEHA+LLCN+FL GKKA +L+G ++ EG AYV+T E
Sbjct: 125 ENDGSDIWMTSEHCISLAIGNKEEHAILLCNFFLYFGKKALVLLGTSVLEGHVAYVVTQE 184
Query: 1296 QGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWK 1355
YL+WNP +G Y QFD FCPLK+V CL N+WFNIQ+ +P+ + FD ++ WK
Sbjct: 185 TNEYLLWNPSTGQCYKQFDPFCPLKSVDCLFDDRNVWFNIQQNNTPMAVFFDYSKESFWK 244
Query: 1356 SFFSRSLPYPGLSSVQ 1371
+++ + S+Q
Sbjct: 245 QLLPKNVQGTKIQSIQ 260
Score = 93.2 bits (230), Expect = 2e-18
Identities = 37/61 (60%), Positives = 52/61 (85%)
Query: 1452 SGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRN 1511
+GFP+ MPY +V+ +IDAVY TG+H+ + P EFALAVYIHPYP N+LSVW+Y+ASL+++
Sbjct: 262 TGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYLASLVQH 321
Query: 1512 R 1512
+
Sbjct: 322 Q 322
>gi|21314728 centrosomal protein 76kDa [Homo sapiens]
Length = 659
Score = 65.1 bits (157), Expect = 5e-10
Identities = 77/349 (22%), Positives = 135/349 (38%), Gaps = 40/349 (11%)
Query: 1192 ITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPF-LPDTVSFGGICDLWSTSDQFL 1250
+ Y+KPL L T AR+V+++ + + GG + W T FL
Sbjct: 320 VCSYVKPLRA---------GRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFL 370
Query: 1251 DLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLT-WEQGRYLIWNPCSGHF 1309
GD E+HA LLC+ L G +A++ +G P A+V+T G W +GH
Sbjct: 371 CRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGAITFWESLTGHR 430
Query: 1310 Y-------------GQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKS 1356
Y Q P + +GC+ N Q ++ FD+ WK
Sbjct: 431 YIHKPTNPDEPPVAEQPKPLYPYRTIGCVFNHQMFLGNCQPSDAVETCVFDLNDESKWKP 490
Query: 1357 FFS---RSLPYPGLSSVQP--EELIYQRSDKAAAA-ELQDRIEKILKEKIMDWRPRHLTR 1410
+S+ PG ++ P L D + + E++ ++ ++ E D T
Sbjct: 491 MSEEAIKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDL--GLTTV 548
Query: 1411 WNRYCTSTLRHFLPLLEKSQGEDV---EDDHRAELLKQLGD-YRFSGFPLHMPYSEVK-- 1464
W + L L E + + ++ + + + + D + F GFP+H Y +
Sbjct: 549 WEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRA 608
Query: 1465 --PLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRN 1511
+ + + + V A+ V + YP++ +VWI A R+
Sbjct: 609 FATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRS 657
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 333 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 380
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 381 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 419
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 420 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 476
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 477 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 532
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 533 KAWRKVQRAKKKKRKQAAEE 552
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 333 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 380
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 381 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 419
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 420 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 476
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 477 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 532
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 533 KAWRKVQRAKKKKRKQAAEE 552
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 333 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 380
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 381 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 419
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 420 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 476
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 477 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 532
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 533 KAWRKVQRAKKKKRKQAAEE 552
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 48.5 bits (114), Expect = 5e-05
Identities = 50/209 (23%), Positives = 88/209 (42%), Gaps = 13/209 (6%)
Query: 441 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLRE------FQRFTNTPLK---LVLRKEKAD 491
+T +F D EQ + R LL+ K +E + R FQ + VLRKE+
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 492 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 551
+ +E + E+Q E +L + +E ++ +E Q+ + ++++R ++++R++ E
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 552 EHPGD----EIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSL 607
E E E E+ L + + EQE R Q RR E +L
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 608 AGSVTPNDQCPRAEVSRREDVKKRSVYLK 636
+ Q R + RRE +R L+
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLR 408
Score = 44.7 bits (104), Expect = 7e-04
Identities = 50/220 (22%), Positives = 105/220 (47%), Gaps = 10/220 (4%)
Query: 387 DQYLARHQRNKAKFLTDKLQA-LRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKF 445
+Q R QR K + ++LQ LR+ Q + E+ + L ++ + E R+ R
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE-KRLEQERREQRLK 568
Query: 446 RDAEQEKDRTLLKTIIKVWKEMKSLRE---FQRFTNTPLKLVLRKEKADQKADEEAYEAE 502
R+ E+ +D+ L + + + +K +E QR ++ + ++E+ +Q+ E E E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 503 IQAEI--SELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
+ ++ SE EE ++ ++ ++ R Q+ K + +R +++ +++ EE E+AE
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERRE-QRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 561 PYPEE--DLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 598
E+ + +K P+ + E + R+ SR R E
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Score = 38.5 bits (88), Expect = 0.050
Identities = 49/215 (22%), Positives = 85/215 (39%), Gaps = 23/215 (10%)
Query: 429 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKE 488
Q+ E + E R+ + R+ E+E+ L+ ++ +E + RE Q L+ +
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 489 KADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQ 548
+ Q E+ E Q + E H +++ Q+ E R +Q +R KR++
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ------EERRDWLKREE 462
Query: 549 AAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAV-IEQEVR----ERAAQSRRRPWEPTLVP 603
E H + ++ L + E +R + +E+E R ER Q RR E
Sbjct: 463 ETERHEQER-----RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 604 ELS-------LAGSVTPNDQCPRAEVSRREDVKKR 631
L L + Q R + RRE + KR
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Score = 38.5 bits (88), Expect = 0.050
Identities = 47/208 (22%), Positives = 89/208 (42%), Gaps = 16/208 (7%)
Query: 392 RHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKS-EIRQTRKFRDAEQ 450
R + + +FL ++ Q R L E+ D +Q+ +S E R+ +K+R +
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEE-----DGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 451 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL 510
E+ + T+ + LR+ Q+ + + R+E+ ++ E+ E Q E
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ----ERQYREEEQ 935
Query: 511 LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP 570
L++ E+ ++ E R ++ + +RK K+ Q EE E E ++ K
Sbjct: 936 LQQEEEQLLREEREKRRRQERERQYRK------DKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 571 SPPEPTDRAVIEQEVRERAAQSRRRPWE 598
E + EQ +RE + RR+ WE
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWE 1017
Score = 38.5 bits (88), Expect = 0.050
Identities = 45/232 (19%), Positives = 98/232 (42%), Gaps = 23/232 (9%)
Query: 387 DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQT---R 443
++ R Q + KF+ D+ Q R Q L E+ + + Q + ++ + R
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 444 KFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEI 503
KF + E + R + ++ ++ K RE ++ + LR+++ D+K EE +
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRK-FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 504 QAEISELLEEHT------------EEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 551
Q + L+E EE + E + L++ + +RK+ ++ + ++ +
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 552 EHPGDEIAEPYPEEDLVKPSPPE------PTDRAVIEQE-VRERAAQSRRRP 596
+ E + EE+ ++ E +DR E+E +R+ + + RP
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Score = 37.0 bits (84), Expect = 0.14
Identities = 119/602 (19%), Positives = 223/602 (37%), Gaps = 67/602 (11%)
Query: 58 KLQAARSKAESALLQEIPTPRPRRLRSPSKKE-LETEFGTEPGKEVERTQQEVDSQSYSR 116
K + + + L +E R +RL+ ++E LE E E ER +QE+ + +
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE--HEEERREQELAEEEQEQ 692
Query: 117 VKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEG 176
+ +R K + Q+ S +A ++ + EG + + + + E +
Sbjct: 693 ARERIKSRIPKWQWQLE----SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 177 EEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQME--- 233
+EEE + +E + AE+ ++ RP E +L+ E
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEE----KSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 234 -REMLFIPSRQTVPTYKKLPENVQP--RFLEDEGLYTGVRPEVARTNQNIMENRLLMQDP 290
RE F+P + ++ + +FLE+E R E A+ Q E L +D
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ--RRERAQQLQE--EEDGLQEDQ 860
Query: 291 ERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAV--KYVHSSQHVIRS 348
ERR + R + E+ K TLY K + + Q +++
Sbjct: 861 ERRRSQEQRR------------DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 349 GDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLY--DQYLARHQRNKAKFLTDKLQ 406
+ Q + + E L + QL ++ R Q + ++ DK
Sbjct: 909 EEE--ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 407 ALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVW-K 465
+ G +PEK + +K E + ++ + E+EK R + W +
Sbjct: 967 QQKEEQLLGEEPEKRRRQ--EREKKYREEEELQQEEEQLLREEREKRRR------QEWER 1018
Query: 466 EMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELL-EEHTEEYAQKME- 523
+ + E Q+ L+ K + ++ + E E+Q E +LL EE Q++E
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 524 EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQ 583
+YR + + ++ R + +KR++ E E E EE+ + E R +E+
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 584 E--------------VRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVK 629
+ +RE + RR+ E E L +Q R E +R +
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ---QEEEQLLREEQEKRRQER 1195
Query: 630 KR 631
+R
Sbjct: 1196 ER 1197
Score = 33.5 bits (75), Expect = 1.6
Identities = 47/222 (21%), Positives = 96/222 (43%), Gaps = 19/222 (8%)
Query: 387 DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIR---QTR 443
++ L R +R + + + + R Q L E+ Q L ++ + E+R Q R
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQ--LLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 444 KFRDAEQ-----EKDRTLLKTI--IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADE 496
KF + EQ E++R LK ++ + + LR+ + + L +++ D+K E
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 497 EAYEAEIQAEISELLEEH---TEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEH 553
E + Q + LEE +E +K E LQ+ + + ++ + +K + ++
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 554 PGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 595
E + E++L P +R +E+E + Q +R+
Sbjct: 1495 RRQERDRKFREQELRSQEP----ERKFLEEEQQLHRQQRQRK 1532
Score = 33.1 bits (74), Expect = 2.1
Identities = 49/227 (21%), Positives = 99/227 (43%), Gaps = 21/227 (9%)
Query: 375 EHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGL--DPEKPHQSLDTIQKTI 432
E +L + + Q R R K + ++ Q LR + + E+ ++ + +Q+
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 433 NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQ 492
+ E R+TR+ ++ E++ + +E E Q P K R+E+ Q
Sbjct: 1061 EQLLGEERETRRRQELERQYRK----------EEELQQEEEQLLREEPEKR-RRQERERQ 1109
Query: 493 KADEEAYEAEIQAEISELLEEHTEEYA-QKME-EYRTS--LQQWKAWRKVQRAKKKKRKQ 548
+EE E+Q E +LL E E+ Q++E +YR +QQ + + +K++R++
Sbjct: 1110 CREEE----ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Query: 549 AAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 595
++ +E + E+ L + +R +E E Q R++
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Score = 32.0 bits (71), Expect = 4.7
Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 7/108 (6%)
Query: 486 RKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 545
R+ + Q+ + E E E Q+E E LE+ + ++ EE Q+W+ +R +++
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQ--RRDEELWRQRQEWQ-----EREERRA 188
Query: 546 RKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSR 593
++ + G E E EE L + E + E++ + R Q R
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 47.8 bits (112), Expect = 8e-05
Identities = 56/230 (24%), Positives = 98/230 (42%), Gaps = 34/230 (14%)
Query: 389 YLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIR----QTRK 444
+L Q NK + + Q L Q E Q L QK I + K + R Q R+
Sbjct: 356 FLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 445 FRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQ 504
R+A ++++R + + +E + L E +R ++E+ ++A+EE E +
Sbjct: 416 EREARRQQEREQRR---REQEEKRRLEELERRR--------KEEEERRRAEEEKRRVERE 464
Query: 505 AE-ISELLEE---HTEEYAQKMEEYRTSLQQ--WKAWRKVQRAKKKKRKQAAEE------ 552
E I LEE H E Q++ + + L + W+ + ++A++ +R+ E+
Sbjct: 465 QEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSL 524
Query: 553 -------HPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 595
HP P P+++ KPS P +A E R R + R R
Sbjct: 525 QHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFR 574
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/214 (22%), Positives = 85/214 (39%), Gaps = 6/214 (2%)
Query: 441 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 500
+ R D EK ++ +K +K ++ KS + P K + +KE+ EE
Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKS--PLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Query: 501 AEIQA-EISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIA 559
E++ E + EE K EE + S ++ ++ + K +++K+ A E P +
Sbjct: 831 QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV 890
Query: 560 EPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRR---RPWEPTLVPELSLAGSVTPNDQ 616
E EE K P P A + EV+E A + EP + +
Sbjct: 891 EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 617 CPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSR 650
P + ++ E KK K KE +T+S+
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984
Score = 35.0 bits (79), Expect = 0.55
Identities = 47/187 (25%), Positives = 81/187 (43%), Gaps = 33/187 (17%)
Query: 12 QEPVQEEPKTRLLSMTVRRGPRSLPP--IPSTSRTGFAEFSMRGRMREKLQAARSKAESA 69
+ PV+EE K + + V+ P+ P+T +T EK SK E A
Sbjct: 821 KSPVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKT-----------EEKKD---SKKEEA 864
Query: 70 LLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEV---DSQSYSRVKFHDSARKI 126
+E P P+ + P+ E E E KE +++V + ++ ++V+ + A K
Sbjct: 865 PKKEAPKPKVEEKKEPAV-EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-KP 922
Query: 127 KPKPQVPPGFPSAEEAYNFFTFNFDPEP-EGSEEKPKARHRAGTNQEEEEGEEEEPPAQG 185
K K +V P +A EP + +E+K A + T +E+ + EE+P +
Sbjct: 923 KEKTEVAKKEPDDAKA---------KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEA 973
Query: 186 GGKEMDE 192
KE D+
Sbjct: 974 KAKEDDK 980
Score = 33.5 bits (75), Expect = 1.6
Identities = 26/124 (20%), Positives = 54/124 (43%), Gaps = 4/124 (3%)
Query: 5 KSHLGNPQEPVQEEPK-TRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAAR 63
K + +EP E+PK +++ + + P P E + +EK + A+
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930
Query: 64 SKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEV--DSQSYSRVKFHD 121
+ + A +E P ++ +P KK+ + E +P +E +T+ + D ++ S+
Sbjct: 931 KEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP-EEKPKTEAKAKEDDKTLSKEPSKP 989
Query: 122 SARK 125
A K
Sbjct: 990 KAEK 993
Score = 32.0 bits (71), Expect = 4.7
Identities = 32/144 (22%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 487 KEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKR 546
K K +K+++E E Q E +++ EE TEE EE ++ K + + +
Sbjct: 443 KIKVVEKSEKETVIVEEQTEETQVTEEVTEE-----EEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 547 KQAAEEHPGDEIAEPYPE-EDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPEL 605
++ + P +E A P E + VK P + E+E + A+ + PE
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS--------PEK 549
Query: 606 SLAGSVTPNDQCPRAEVSRREDVK 629
+ + + P A+ +E+ K
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAK 573
Score = 31.6 bits (70), Expect = 6.1
Identities = 38/184 (20%), Positives = 72/184 (39%), Gaps = 29/184 (15%)
Query: 11 PQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESAL 70
P P EE K P+ P P E ++ K++A + +AE
Sbjct: 848 PATPKTEEKK----DSKKEEAPKKEAPKPKVEEK--KEPAVEKPKESKVEAKKEEAEDK- 900
Query: 71 LQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKP 130
+++PTP +P+K E++ + +P ++ E ++E D K + ++ + K
Sbjct: 901 -KKVPTPEKE---APAKVEVKED--AKPKEKTEVAKKEPDD-----AKAKEPSKPAEKKE 949
Query: 131 QVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEM 190
P + EE + + EEKPK +A + + E +P A+ K
Sbjct: 950 AAPEKKDTKEE-----------KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSS 998
Query: 191 DEEE 194
++
Sbjct: 999 STDQ 1002
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/257 (18%), Positives = 108/257 (42%), Gaps = 22/257 (8%)
Query: 395 RNKAKFLTDKLQALRNAVQTGLDPEKPHQSLD------TIQKTINEYKSEI--------R 440
+NK K+ + ++ ++ L + +D T++K ++++ +
Sbjct: 807 KNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPE 866
Query: 441 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 500
++ ++ E D + K + + + +E+ + +L+ +K Q+ +E
Sbjct: 867 MNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERL 926
Query: 501 AEIQAEISELLE--EHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEI 558
IQ E+ + + E E+ +K EE R + +A RK + ++KKR+ ++
Sbjct: 927 RRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKRED------DEKR 980
Query: 559 AEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCP 618
+ E L + E +AV+EQE R+R R E L+ + + A +
Sbjct: 981 IQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRNDGT 1040
Query: 619 RAEVSRREDVKKRSVYL 635
R +++ + K+ S +L
Sbjct: 1041 RPKMTPEQMAKEMSEFL 1057
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 44.7 bits (104), Expect = 7e-04
Identities = 128/627 (20%), Positives = 229/627 (36%), Gaps = 88/627 (14%)
Query: 11 PQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESAL 70
P++PV EE K + P +P +P + + +
Sbjct: 9954 PRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVP 10013
Query: 71 LQEIPTPRPRRLRSPSKKELETEFGTEPGKEVE-RTQQEVDSQSYSRVKFHDSARKIKPK 129
+++P P P+++ +P K E P K+V ++V++ K + +K+ P+
Sbjct: 10014 EEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPP---AKVPEVPKKLIPE 10070
Query: 130 PQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKE 189
+ P P EA P P+ +++ QEEE EEE
Sbjct: 10071 EKKPTPVPKKVEA---------PPPKVPKKREPVPVPVALPQEEEVLFEEE--------I 10113
Query: 190 MDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQT-VPTY 248
+ EEE+L + E+ L + V + V P + E + ++ E ++P + VP
Sbjct: 10114 VPEEEVL--PEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEE 10171
Query: 249 KKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPI 308
+ LPE V+P+ V V + + E ++++ E ++ +P +
Sbjct: 10172 EVLPE-VKPK--------VPVPAPVPEIKKKVTEKKVVIPKKEE---APPAKVPEVPKKV 10219
Query: 309 KP----FPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGL 364
+ P VL E + + E E + ++ + S + PP ++ +
Sbjct: 10220 EEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR--VPEVIKKAV 10277
Query: 365 IFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQS 424
P + AK+++ + K K +A V PE P +
Sbjct: 10278 PEAPTPVPKKVEAPPAKVSK-------KIPEEKVPVPVQKKEAPPAKV-----PEVPKK- 10324
Query: 425 LDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLV 484
+K + K E K R +EK + + V KE L V
Sbjct: 10325 --VPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVV-KERLELE------------V 10369
Query: 485 LRKEKADQKADEEAYEAEIQAEISEL--------LEEHTEEYAQKMEEYRTSLQQWKAWR 536
+ E + +EE +E E E E LE+H E ++E+ ++ ++A
Sbjct: 10370 VEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEA-E 10428
Query: 537 KVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLV--KPSP---PEPTDRAVIEQEVRERAAQ 591
+V+ +K K E I P +V K P PE + V+E++V R +
Sbjct: 10429 EVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKV--RVPE 10486
Query: 592 SRRRPWEPTLVPELSLAGSVTPNDQCP 618
R P PT VPE+ V P + P
Sbjct: 10487 EPRVP--PTKVPEVLPPKEVVPEKKVP 10511
Score = 38.9 bits (89), Expect = 0.038
Identities = 49/203 (24%), Positives = 92/203 (45%), Gaps = 19/203 (9%)
Query: 414 TGLDPEKPHQSLDTIQKTINEYK----SEIRQTRKFRDAEQEKDRTLLK---TIIKVWKE 466
T L P K + +D K E K + ++ +K ++A EK + + K I+ ++E
Sbjct: 9017 TTLIPAKAPEIIDVSSKA-EEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEE 9075
Query: 467 MKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEE---YAQKME 523
E + +T P + +E + D E + E + E+ E EE EE Y ++ E
Sbjct: 9076 PYDELEVEPYTE-PFEQPYYEEPDE---DYEEIKVEAKKEVHEEWEEDFEEGQEYYEREE 9131
Query: 524 EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQ 583
Y ++W+ + +R + +K+ EE ++ PE+ P PP+ + VIE
Sbjct: 9132 GYDEGEEEWEEAYQ-EREVIQVQKEVYEESHERKVPAKVPEKKA--PPPPKVIKKPVIE- 9187
Query: 584 EVRERAAQSRRRPWEPTLVPELS 606
++ + + + + T VPE+S
Sbjct: 9188 KIEKTSRRMEEEKVQVTKVPEVS 9210
Score = 35.8 bits (81), Expect = 0.32
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 3/80 (3%)
Query: 542 KKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTL 601
K RK+ EE P EP E + KP+ PEP +E+ + R+ EPT
Sbjct: 10950 KSVLRKRPEEEEPK---VEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 11006
Query: 602 VPELSLAGSVTPNDQCPRAE 621
VPE+ A + + P+ E
Sbjct: 11007 VPEIKPAIPLPAPEPKPKPE 11026
Score = 35.0 bits (79), Expect = 0.55
Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 3/129 (2%)
Query: 495 DEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWR-KVQRAKKKKRKQAAEEH 553
+E A+E E+ + E L E EEY + EE+ T + KV +K + +
Sbjct: 9906 EEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPV 9965
Query: 554 PGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTP 613
P + E P + P PE +I ++ + A+ P +P VPE + V
Sbjct: 9966 PVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKP--VPEEKVPVPVPK 10023
Query: 614 NDQCPRAEV 622
+ P A+V
Sbjct: 10024 KVEAPPAKV 10032
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 44.3 bits (103), Expect = 0.001
Identities = 37/174 (21%), Positives = 84/174 (48%), Gaps = 18/174 (10%)
Query: 429 QKTINEYKSEI-RQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRK 487
++ I E + ++ RQ K R+ E+++ + K+WK+ + +RE + K+ ++
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQ----EQEEKMWKQEEKIREQEE------KIQEQE 625
Query: 488 EKADQKADEEAYEAEIQAEISELLEEHTE---EYAQKMEEYRTSLQQWKAWRKVQRAKKK 544
EK ++ ++ + E+ E E + E E E +KM+E ++ W+ K++ +KK
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM--WRQEEKIREQEKK 683
Query: 545 KRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 598
R+Q + +E+ + +E+ + + ++ QE E+ + + WE
Sbjct: 684 IREQEEKIREQEEMMQ--EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 735
Score = 37.4 bits (85), Expect = 0.11
Identities = 52/247 (21%), Positives = 109/247 (44%), Gaps = 30/247 (12%)
Query: 364 LIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKA--KFLTDKLQALRNAVQTGLDPEKP 421
L ++ H E +++L+D + + +A T K +A R + L E+
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEE--LTKERD 203
Query: 422 HQSLDTIQKTINEYKSEIRQTR---KFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 478
SL+ + TI + + + + + K + E EK L KE+K R+ +R
Sbjct: 204 ALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-----KELK--RKLER--- 253
Query: 479 TPLKLVLRKEKADQKADE-----EAYEAEIQAEI--SELLEEHTEEYAQKMEEYRTSLQQ 531
KL+L +++ +AD ++ A++QA++ +EL ++ +KM +Q+
Sbjct: 254 --AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
Query: 532 WKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQ 591
W+ K+Q ++K R+Q EE ++ + +E+++ + + + E E+ +
Sbjct: 312 WE--EKIQEQEEKIREQ--EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 592 SRRRPWE 598
WE
Sbjct: 368 QEEMMWE 374
Score = 35.0 bits (79), Expect = 0.55
Identities = 25/151 (16%), Positives = 67/151 (44%), Gaps = 10/151 (6%)
Query: 429 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKE 488
+K + K RQ K + E+ ++ + ++W++ + + E + K+ ++E
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 489 KADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQW----------KAWRKV 538
K ++ ++ + E E E + E E+ ++ E+ R + W K W +
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 539 QRAKKKKRKQAAEEHPGDEIAEPYPEEDLVK 569
+R +++ + EE ++ + + +E+ ++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594
Score = 33.1 bits (74), Expect = 2.1
Identities = 42/220 (19%), Positives = 102/220 (46%), Gaps = 27/220 (12%)
Query: 382 LAQLYDQYLARHQRNKAKFLTDKLQAL--RNAVQTGLDPEKPHQSLDTIQKTINEYKSEI 439
L Q Q A H + + ++ KLQA N + L+ ++ + +K I E++ +I
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK-IQEWEEKI 316
Query: 440 R-QTRKFRDAEQ---EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKAD 495
+ Q K R+ E+ E++ + + +W++ + +R + +++ KE+ ++ +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE-------EMMWEKEEKMRRQE 369
Query: 496 EEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPG 555
E +E E E EE E +K+ E + + + R+ + ++++ K +E
Sbjct: 370 EMMWEKE---EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 556 DEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 595
++ A+ + +E+ ++ E+++RE+ + R+
Sbjct: 427 EQEAKMWRQEEKIREQ----------EEKIREQEKKMWRQ 456
Score = 32.7 bits (73), Expect = 2.7
Identities = 31/149 (20%), Positives = 70/149 (46%), Gaps = 24/149 (16%)
Query: 419 EKPHQSLDTIQ---KTINEYKSEIRQTRKFRDAEQEK-----------DRTLLKTIIKVW 464
EK + + IQ + I E + +IR+ + ++EK + + + +W
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMW 671
Query: 465 KEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEE 524
++ + +RE ++ + + +E+ Q+ +E+ +E E ++ E+ EE Q+ EE
Sbjct: 672 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE-----EKMCEQ--EEKMQEQEE 724
Query: 525 YRTSLQQWKAWRKVQRAKKKKRKQAAEEH 553
+ Q+ K W + R ++++ K +EH
Sbjct: 725 -KMRRQEEKMWEQEVRLRQQEEKM--QEH 750
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 30/184 (16%)
Query: 2 VSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPP--IPSTSRTGFAEFSMRGRMREKL 59
+ EK Q +++E + R L RR R S RT + + R R +
Sbjct: 192 LEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQ 251
Query: 60 QAA-------RSKAESALLQEIPTPRPRRLRSP-SKKEL---ETEFGTEPGKEVERTQQE 108
++A + K + I +P+P +LRSP +K+L ET FG EP + R + +
Sbjct: 252 ESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRAD 311
Query: 109 VDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAG 168
+ ++ +P P PP AEE + PE E E+P + G
Sbjct: 312 LPAE--------------EPAPSTPPCLVQAEEE---AVYEEPPEQETFYEQPPLVQQQG 354
Query: 169 TNQE 172
E
Sbjct: 355 AGSE 358
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 31/185 (16%)
Query: 2 VSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPP---IPSTSRTGFAEFSMRGRMREK 58
+ EK Q +++E + R L RR R SRT + + R R +
Sbjct: 192 LEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNE 251
Query: 59 LQAA-------RSKAESALLQEIPTPRPRRLRSP-SKKEL---ETEFGTEPGKEVERTQQ 107
++A + K + I +P+P +LRSP +K+L ET FG EP + R +
Sbjct: 252 QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRA 311
Query: 108 EVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRA 167
++ ++ +P P PP AEE + PE E E+P +
Sbjct: 312 DLPAE--------------EPAPSTPPCLVQAEEE---AVYEEPPEQETFYEQPPLVQQQ 354
Query: 168 GTNQE 172
G E
Sbjct: 355 GAGSE 359
Score = 31.2 bits (69), Expect = 7.9
Identities = 34/191 (17%), Positives = 75/191 (39%), Gaps = 15/191 (7%)
Query: 391 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 450
A H A FL + + ++PE ++ + K S +++ +F+D
Sbjct: 98 ASHVSTMASFLKGAHVTINARAEEDVEPEC---IMEKVAKASGANYSFHKESGRFQDVGP 154
Query: 451 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEIS-E 509
+ + V+++ ++ E +R KE+ +++ +E+ E Q ++ E
Sbjct: 155 QAP------VGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
Query: 510 LLEEHTEEYAQKMEEYRT----SLQQWKAWRKVQRAKKKKR-KQAAEEHPGDEIAEPYPE 564
E E A++ + Y+ + Q + W + Q + R +Q + HP + +
Sbjct: 209 RRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERA 268
Query: 565 EDLVKPSPPEP 575
S P+P
Sbjct: 269 MSTTSISSPQP 279
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/205 (20%), Positives = 91/205 (44%), Gaps = 25/205 (12%)
Query: 421 PHQSLDTIQKTINEYKSEIR-QTRKFRDAEQ----------EKDRTLLKTIIKVWKEMKS 469
P +T+Q+ + + E+R Q +K R E+ E++ + + K+W++ K
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322
Query: 470 LREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQA-EISELLEEHTE------------ 516
LRE ++ K LR++K ++ +E+ E E + E E + E E
Sbjct: 323 LREQEKELREQEK-ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 517 EYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPT 576
E + +E + Q+ + W + +R ++K+ + +E +++ + E+ + +
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD 441
Query: 577 DRAVIEQEVRERAAQSRRRPWEPTL 601
+++E R R + + R E T+
Sbjct: 442 QEEKMQEEERIREREKKMREEEETM 466
Score = 43.5 bits (101), Expect = 0.002
Identities = 33/159 (20%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 441 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 500
Q +K D E+ ++ + K W + + +RE +R K +R+E+ + EE +
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK--MREEEEMMREQEE--K 611
Query: 501 AEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
+ Q E + EE E +KM+E Q+ K W + ++ +++ K ++ ++ +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQE-----QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 561 PYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSR-RRPWE 598
+ E + + + + + EQE E+ Q + ++ W+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705
Score = 42.0 bits (97), Expect = 0.004
Identities = 38/187 (20%), Positives = 88/187 (47%), Gaps = 12/187 (6%)
Query: 417 DPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 476
D E+ + + +++ + + E R+ + QE++ + + K+W++ + ++E +
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE- 638
Query: 477 TNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTE-EYAQKMEEYRTSL-QQWKA 534
K+ ++EK ++ +E+ +E + E E L EH + + +KM+E + +Q K
Sbjct: 639 -----KMWEQEEKMWEQ-EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM 692
Query: 535 WRKVQRAKKK---KRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQ 591
+K Q +KK + K EE + + EE++++ + ++ QE E +
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 592 SRRRPWE 598
+ WE
Sbjct: 753 QEEKMWE 759
Score = 38.1 bits (87), Expect = 0.065
Identities = 35/146 (23%), Positives = 74/146 (50%), Gaps = 14/146 (9%)
Query: 434 EYKSEIR-QTRKFRDAEQ---EKDRTL------LKTIIKVWKEMKSLREFQRFTNTPLKL 483
E + ++R Q +K RD E+ E+D L ++ K+W++++ +RE ++ K
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 484 VLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKK 543
++EK ++ E +++ E + E+ EE QK EE Q+ K W++ QR +
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQ--EEKMQKQEENMWE-QEEKEWQQ-QRLPE 495
Query: 544 KKRKQAAEEHPGDEIAEPYPEEDLVK 569
+K K +E ++ + + +E+ ++
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIR 521
Score = 38.1 bits (87), Expect = 0.065
Identities = 38/178 (21%), Positives = 79/178 (44%), Gaps = 28/178 (15%)
Query: 434 EYKSEIRQTRKFRDAE--QEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKAD 491
E K + ++ + + E QE++ + + K+W++ + + E QR +
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL-------------PE 662
Query: 492 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAW-----RKVQRAKKKKR 546
QK E+ +E E E ++ E+ + + Q+ E +T Q+ K W R+ + +++++
Sbjct: 663 QK--EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 547 KQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPE 604
K EE E E E++ + + + EQE E+ + + WE +PE
Sbjct: 721 KMREEEEMMREQEEKMQEQE----EKMQEQEEEMWEQE--EKMWEQEEKMWEQQRLPE 772
Score = 32.7 bits (73), Expect = 2.7
Identities = 37/181 (20%), Positives = 79/181 (43%), Gaps = 7/181 (3%)
Query: 420 KPHQSLDTIQKTINEYKSEIR-QTRKFRDAE---QEKDRTLLKTIIKVWKEMKSLREFQR 475
+ +S+ +K + E + +R Q K ++ E QE++ + + K+W++ + + E QR
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 476 FTNTPLKLVLRKEKADQ-KADEEAYEAEIQAEISELLEEHTEEYAQKM--EEYRTSLQQW 532
KL ++ +Q K E+ + Q E EE +KM +E + Q+
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
Query: 533 KAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQS 592
K W + ++ ++ K +E +E + E+ + + + EQE + R +
Sbjct: 830 KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Query: 593 R 593
+
Sbjct: 890 K 890
Score = 31.6 bits (70), Expect = 6.1
Identities = 33/189 (17%), Positives = 83/189 (43%), Gaps = 29/189 (15%)
Query: 429 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLR-- 486
Q+ + E K ++ + K ++ E+ K+W++ + +R+ + K+ +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEE-----------KIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 487 -KEKADQKADEEAYEAEIQAEI---SELLEEHTEE-------YAQKMEEYRTSLQQWKAW 535
+E+ DQ ++E + + ++ E +E+ T+E +KM E ++ K
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 536 RKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 595
R+ + +++ ++ E+ +E + E+ + + + + EQE E+ + +
Sbjct: 599 REEEEMMREQEEKMQEQ---EEKMQEQEEKMWEQEEKMQEQEEKMWEQE--EKMWEQEEK 653
Query: 596 PWEPTLVPE 604
WE +PE
Sbjct: 654 MWEQQRLPE 662
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 43.5 bits (101), Expect = 0.002
Identities = 86/443 (19%), Positives = 166/443 (37%), Gaps = 68/443 (15%)
Query: 153 EPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVA 212
EP+ EE+ + +++ EE ++E A+ E +E E + +
Sbjct: 237 EPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ------------ 284
Query: 213 DDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPE 272
D +A A E+ ERE R+ + +K + R E+E R
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
Query: 273 VARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLY 332
+ + E R +++ E+R + R A +E+ K E +
Sbjct: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARA---------------EEEEKAKVEEQKRN 389
Query: 333 KKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLAR 392
K+ + H+ Q G+ +++ I G + + + + A L + ++ +
Sbjct: 390 KQLEEKKHAMQETKIKGE-----KVEQKIEGK-WVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 393 HQRNKAKFLTD-----KLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQ--TRKF 445
Q + K D K + ++ +P++ +S +K E KS+ + T K
Sbjct: 444 VQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 503
Query: 446 RDAEQEKDRTLLKTI-----------IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKA 494
+ E R + ++ K ++ LR + T + EK QK
Sbjct: 504 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE-----EFEKLKQKQ 558
Query: 495 DEEAYEAE----IQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAA 550
E A E E + E ++LEE EE +K EE L++ + R+++ +++R +AA
Sbjct: 559 QEAALELEELKKKREERRKVLEE--EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616
Query: 551 EEHPGDEIAEPYPEEDLVKPSPP 573
E+ + PE+ L P
Sbjct: 617 EKR------QKMPEDGLSDDKKP 633
Score = 34.7 bits (78), Expect = 0.72
Identities = 26/115 (22%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 488 EKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRK 547
E+A +A+E+A E + +E E EE + EE + ++ K + ++ K++ K
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
Query: 548 QAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLV 602
+AAEE + E E+ + + E ++A +E++ R + + ++ + T +
Sbjct: 351 RAAEERQRIKEEEKRAAEERQR-ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 373 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 425
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 221 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 274
Query: 426 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 481
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 275 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 327
Query: 482 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 539
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 328 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 385
Query: 540 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 587
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 386 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 442
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 373 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 425
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 308 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 361
Query: 426 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 481
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 362 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 414
Query: 482 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 539
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 415 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 472
Query: 540 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 587
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 473 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 373 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 425
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 292 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 345
Query: 426 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 481
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 346 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 398
Query: 482 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 539
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 399 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 456
Query: 540 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 587
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 457 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 513
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 373 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 425
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 307 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 360
Query: 426 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 481
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 413
Query: 482 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 539
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 414 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 471
Query: 540 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 587
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 472 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 528
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 42.7 bits (99), Expect = 0.003
Identities = 42/216 (19%), Positives = 100/216 (46%), Gaps = 14/216 (6%)
Query: 392 RHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEI-RQTRKFRDAE- 449
+ + +AKFL ++Q N +Q + + + L +K I + + ++ RQ + R+ E
Sbjct: 214 KRKLERAKFLLPQVQT--NTLQEEM--WRQEEELREQEKKIRKQEEKMWRQEERLREQEG 269
Query: 450 --QEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEI 507
+E++ + + ++ ++ K LRE ++ KL ++E+ ++ ++ + E E
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 508 SELL---EEHTEEYAQKMEEYRTSL--QQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPY 562
E + EE E ++M E + Q+ + W + +R ++K+ + +E ++ E
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ-EEKM 388
Query: 563 PEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 598
EE+ ++ + + +E E+ + WE
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Score = 38.1 bits (87), Expect = 0.065
Identities = 73/456 (16%), Positives = 180/456 (39%), Gaps = 44/456 (9%)
Query: 158 EEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVA 217
EE+ + + + QEE+ +EE + GK ++EE + + + +
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR--------LREQEKE 291
Query: 218 VRPADYESIHDR-LQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVART 276
+R + E + L+ + E + + +K+ E + + ++E L+
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW--------EQ 343
Query: 277 NQNIMENRLLMQDPERRWFGDDGRILALPNPIKP----------FPSRPPVLTQEQSIKA 326
+ + E M+D E R + D R+ ++ + +E+ ++
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 327 ELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLY 386
E ET+ ++ K +++ + Q + ++ +E + + ++
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 387 DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFR 446
DQ Q K + +K++ + + E+ + D QK ++ + Q + R
Sbjct: 464 DQEEMWGQEKKM-WRQEKMREQEDQMW-----EQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 447 DAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEK--ADQKADEEAYEAEIQ 504
+ E+ ++ K+W++ + +RE ++ K ++EK +++ E + +
Sbjct: 518 EKEER-----MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 505 AEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPE 564
E+ EE +E +KM E + W+ K+Q ++K +Q + +E + +
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKM--WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 565 EDLV--KPSPPEPTDRAVIEQEVRERAAQSRRRPWE 598
E+++ + + + + EQE + R + + R E
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Score = 36.2 bits (82), Expect = 0.25
Identities = 23/141 (16%), Positives = 69/141 (48%), Gaps = 4/141 (2%)
Query: 417 DPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 476
D E+ + + +++ + + E R+ + QE++ + + K+W++ + ++E +
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 477 TNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWR 536
+ + +E+ D+ ++E E+ E E ++E E+ ++ E+ R ++ +
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQE----EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Query: 537 KVQRAKKKKRKQAAEEHPGDE 557
+ + +++K ++ E+ G E
Sbjct: 667 EKMQGQEEKMREQEEKMQGQE 687
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 42.7 bits (99), Expect = 0.003
Identities = 43/183 (23%), Positives = 86/183 (46%), Gaps = 16/183 (8%)
Query: 424 SLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIK-VWKEMKSLREFQRFTNTPLK 482
S++ +K E K+++++ K RD E+EKD+ K+ K KE + +E R T P K
Sbjct: 518 SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK 577
Query: 483 LVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAK 542
L++E+AD Y+ +I + E+ K++ +++ K K ++
Sbjct: 578 EFLKEEEAD------PYKFKI---------KEFEDVDPKVKLKDGLVRKEKEKHKDKKKD 622
Query: 543 KKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLV 602
++K K+ ++ +++ + E+ + P+PP + + A SR P+L+
Sbjct: 623 REKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLL 682
Query: 603 PEL 605
P L
Sbjct: 683 PVL 685
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/259 (20%), Positives = 105/259 (40%), Gaps = 42/259 (16%)
Query: 393 HQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEK 452
H R+K K +K++ + + E+ + K + R K RD E+EK
Sbjct: 372 HSRDKRKDTREKIKEKERVKEKDREKEREREK--------EREKEKERGKNKDRDKEREK 423
Query: 453 DRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLE 512
DR K+ + RE +R KE + E+ E + + E +
Sbjct: 424 DRE---------KDKEKDRERER----------EKEHEKDRDKEKEKEQDKEKEREKDRS 464
Query: 513 EHTEEYAQKMEEYRTSLQQWKAWRKVQ-RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPS 571
+ +E +K ++ RT + + A R+ + +++++R+++ ++ + PS
Sbjct: 465 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524
Query: 572 PPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKR 631
P + ++ R+ ++ R R E S + + ND+ +E ++K
Sbjct: 525 PRSRNKKDKKREKERDHISERRER--------ERSTSMRKSSNDR------DGKEKLEKN 570
Query: 632 SVYLKVLFNNKEVSRTVSR 650
S LK +NKE +VS+
Sbjct: 571 STSLKEKEHNKEPDSSVSK 589
Score = 34.7 bits (78), Expect = 0.72
Identities = 44/165 (26%), Positives = 66/165 (40%), Gaps = 47/165 (28%)
Query: 29 RRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKK 88
R+G RS S SR+ S R R + K +RS S Q+ RR +SP KK
Sbjct: 303 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQK----DRRRSKSPHKK 357
Query: 89 ELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTF 148
++ R +++ S+S+SR K D+ KIK K +V
Sbjct: 358 RSKS-----------RERRKSRSRSHSRDKRKDTREKIKEKERV---------------- 390
Query: 149 NFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEE 193
+EK + + R E E E E+ +G K+ D+E
Sbjct: 391 ---------KEKDREKER------EREKEREKEKERGKNKDRDKE 420
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/259 (20%), Positives = 105/259 (40%), Gaps = 42/259 (16%)
Query: 393 HQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEK 452
H R+K K +K++ + + E+ + K + R K RD E+EK
Sbjct: 256 HSRDKRKDTREKIKEKERVKEKDREKEREREK--------EREKEKERGKNKDRDKEREK 307
Query: 453 DRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLE 512
DR K+ + RE +R KE + E+ E + + E +
Sbjct: 308 DRE---------KDKEKDRERER----------EKEHEKDRDKEKEKEQDKEKEREKDRS 348
Query: 513 EHTEEYAQKMEEYRTSLQQWKAWRKVQ-RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPS 571
+ +E +K ++ RT + + A R+ + +++++R+++ ++ + PS
Sbjct: 349 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 408
Query: 572 PPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKR 631
P + ++ R+ ++ R R E S + + ND+ +E ++K
Sbjct: 409 PRSRNKKDKKREKERDHISERRER--------ERSTSMRKSSNDR------DGKEKLEKN 454
Query: 632 SVYLKVLFNNKEVSRTVSR 650
S LK +NKE +VS+
Sbjct: 455 STSLKEKEHNKEPDSSVSK 473
Score = 34.7 bits (78), Expect = 0.72
Identities = 44/165 (26%), Positives = 66/165 (40%), Gaps = 47/165 (28%)
Query: 29 RRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKK 88
R+G RS S SR+ S R R + K +RS S Q+ RR +SP KK
Sbjct: 187 RKGGRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQK----DRRRSKSPHKK 241
Query: 89 ELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTF 148
++ R +++ S+S+SR K D+ KIK K +V
Sbjct: 242 RSKS-----------RERRKSRSRSHSRDKRKDTREKIKEKERV---------------- 274
Query: 149 NFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEE 193
+EK + + R E E E E+ +G K+ D+E
Sbjct: 275 ---------KEKDREKER------EREKEREKEKERGKNKDRDKE 304
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 42.4 bits (98), Expect = 0.003
Identities = 51/237 (21%), Positives = 110/237 (46%), Gaps = 21/237 (8%)
Query: 381 KLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIR 440
++ +L + A + + K++++K + ++ GL+PE IQK I +K E+R
Sbjct: 673 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPE--------IQKLIARHKQEVR 724
Query: 441 QTRKFRDAE-QEKDRTLLKTIIKVWKEMKSL--REFQRFTNTPLKLVLRKEKAD----QK 493
+ + +AE + D + ++ +E++ RE + + ++++A+ ++
Sbjct: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQ 784
Query: 494 ADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQA---- 549
EE+ A +A +E + E+ + E T QQ + R+ A + ++++A
Sbjct: 785 QLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN 844
Query: 550 AEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELS 606
E+ +EI + +E + E D A+ ++E E+AA+SR + ELS
Sbjct: 845 REQELREEIRKGRDKEIELVIHRLE-ADMALAKEE-SEKAAESRIKRLRDKYEAELS 899
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 42.0 bits (97), Expect = 0.004
Identities = 77/346 (22%), Positives = 137/346 (39%), Gaps = 55/346 (15%)
Query: 222 DYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPR-FLEDEGLYTGVRPEVARTNQNI 280
D S+ +LQ +E+L +RQ + KL + + R L+D+ E QN+
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNL 1362
Query: 281 MEN----RLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAV 336
+ + + D +++ + AL K F LTQ+ KA Y K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA---AAYDKLE 1419
Query: 337 KYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRN 396
K + Q + + +D+D + ++ K + +DQ LA +
Sbjct: 1420 KTKNRLQQEL------DDLVVDLDNQRQLVSN----------LEKKQRKFDQLLAEEKNI 1463
Query: 397 KAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTL 456
+K+ ++ +A A + E SL + E K E+ +T K AE E L
Sbjct: 1464 SSKYADERDRAEAEA----REKETKALSLARALEEALEAKEELERTNKMLKAEMED---L 1516
Query: 457 LKTIIKVWKEMKSLREFQRFTNTPL---KLVLRKEKADQKADEEA--------------Y 499
+ + V K + L + +R T + K L + + + +A E+A +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 500 EAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 545
E ++QA E EE + +++ EY T L+ + R + A KKK
Sbjct: 1577 ERDLQAR-DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Score = 33.9 bits (76), Expect = 1.2
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 462 KVWKEMKSLREFQRFTNTPLKLVLRKEKADQ------KADEEAYEAEIQAEISELLEEHT 515
K+ KE K L E R ++ L +EKA K + E E++ + E +
Sbjct: 996 KLSKERKLLEE--RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 516 EEYAQKME-------EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
E+ +K+E E LQ A K+Q AKK++ QAA DEIA+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Score = 33.5 bits (75), Expect = 1.6
Identities = 85/400 (21%), Positives = 152/400 (38%), Gaps = 69/400 (17%)
Query: 171 QEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRL 230
+ E E EE + K+ + EE+L+ +A L+ D ++ + L
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEAR-----LEEEEDRGQQLQAERKKMAQQML 953
Query: 231 QMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRL----- 285
+E ++ + + +K+ + + LEDE L + + ++E R+
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 286 -LMQDPERRWFGDDGRILALPNPIKPFPSRPPV-LTQEQSIKAELETLYKKAVKYVHSSQ 343
L ++ E+ + L N + S V L +E+ + ELE L +K
Sbjct: 1014 NLAEEEEKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL-------- 1060
Query: 344 HVIRSGDPPGNFQLDIDISGLIFT-HHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLT 402
GD + D+ I +E L A LA+L D+ Q+N A
Sbjct: 1061 ----EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---QKNNALKKI 1113
Query: 403 DKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKD--RTLLKTI 460
+L+ + +Q LD E+ ++ QK RD +E + +T L+
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQK---------------RDLGEELEALKTELEDT 1158
Query: 461 IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQ 520
+ + LR + T LK L +E ++EA++Q E +++AQ
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQ--------EMRQKHAQ 1203
Query: 521 KMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
+EE L+Q+K +A K KQ E+ D E
Sbjct: 1204 AVEELTEQLEQFKR----AKANLDKNKQTLEKENADLAGE 1239
Score = 32.0 bits (71), Expect = 4.7
Identities = 24/134 (17%), Positives = 64/134 (47%), Gaps = 2/134 (1%)
Query: 419 EKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 478
++ ++ ++ NE +E +K A Q+ +R + K+ + +++ +F +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS--KFKS 1814
Query: 479 TPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKV 538
T L + + +++ ++EA E + + + ++ +E ++E+ R +Q+K +
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 539 QRAKKKKRKQAAEE 552
A+ K+ K+ EE
Sbjct: 1875 GNARVKQLKRQLEE 1888
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 42.0 bits (97), Expect = 0.004
Identities = 77/346 (22%), Positives = 137/346 (39%), Gaps = 55/346 (15%)
Query: 222 DYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPR-FLEDEGLYTGVRPEVARTNQNI 280
D S+ +LQ +E+L +RQ + KL + + R L+D+ E QN+
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNL 1369
Query: 281 MEN----RLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAV 336
+ + + D +++ + AL K F LTQ+ KA Y K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA---AAYDKLE 1426
Query: 337 KYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRN 396
K + Q + + +D+D + ++ K + +DQ LA +
Sbjct: 1427 KTKNRLQQEL------DDLVVDLDNQRQLVSN----------LEKKQRKFDQLLAEEKNI 1470
Query: 397 KAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTL 456
+K+ ++ +A A + E SL + E K E+ +T K AE E L
Sbjct: 1471 SSKYADERDRAEAEA----REKETKALSLARALEEALEAKEELERTNKMLKAEMED---L 1523
Query: 457 LKTIIKVWKEMKSLREFQRFTNTPL---KLVLRKEKADQKADEEA--------------Y 499
+ + V K + L + +R T + K L + + + +A E+A +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 500 EAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 545
E ++QA E EE + +++ EY T L+ + R + A KKK
Sbjct: 1584 ERDLQAR-DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Score = 33.9 bits (76), Expect = 1.2
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 462 KVWKEMKSLREFQRFTNTPLKLVLRKEKADQ------KADEEAYEAEIQAEISELLEEHT 515
K+ KE K L E R ++ L +EKA K + E E++ + E +
Sbjct: 1003 KLSKERKLLEE--RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 516 EEYAQKME-------EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
E+ +K+E E LQ A K+Q AKK++ QAA DEIA+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Score = 33.5 bits (75), Expect = 1.6
Identities = 85/400 (21%), Positives = 152/400 (38%), Gaps = 69/400 (17%)
Query: 171 QEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRL 230
+ E E EE + K+ + EE+L+ +A L+ D ++ + L
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEAR-----LEEEEDRGQQLQAERKKMAQQML 960
Query: 231 QMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRL----- 285
+E ++ + + +K+ + + LEDE L + + ++E R+
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 286 -LMQDPERRWFGDDGRILALPNPIKPFPSRPPV-LTQEQSIKAELETLYKKAVKYVHSSQ 343
L ++ E+ + L N + S V L +E+ + ELE L +K
Sbjct: 1021 NLAEEEEKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL-------- 1067
Query: 344 HVIRSGDPPGNFQLDIDISGLIFT-HHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLT 402
GD + D+ I +E L A LA+L D+ Q+N A
Sbjct: 1068 ----EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---QKNNALKKI 1120
Query: 403 DKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKD--RTLLKTI 460
+L+ + +Q LD E+ ++ QK RD +E + +T L+
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQK---------------RDLGEELEALKTELEDT 1165
Query: 461 IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQ 520
+ + LR + T LK L +E ++EA++Q E +++AQ
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQ--------EMRQKHAQ 1210
Query: 521 KMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
+EE L+Q+K +A K KQ E+ D E
Sbjct: 1211 AVEELTEQLEQFKR----AKANLDKNKQTLEKENADLAGE 1246
Score = 32.0 bits (71), Expect = 4.7
Identities = 24/134 (17%), Positives = 64/134 (47%), Gaps = 2/134 (1%)
Query: 419 EKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 478
++ ++ ++ NE +E +K A Q+ +R + K+ + +++ +F +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS--KFKS 1821
Query: 479 TPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKV 538
T L + + +++ ++EA E + + + ++ +E ++E+ R +Q+K +
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 539 QRAKKKKRKQAAEE 552
A+ K+ K+ EE
Sbjct: 1882 GNARVKQLKRQLEE 1895
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 42.0 bits (97), Expect = 0.004
Identities = 77/346 (22%), Positives = 137/346 (39%), Gaps = 55/346 (15%)
Query: 222 DYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPR-FLEDEGLYTGVRPEVARTNQNI 280
D S+ +LQ +E+L +RQ + KL + + R L+D+ E QN+
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNL 1369
Query: 281 MEN----RLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAV 336
+ + + D +++ + AL K F LTQ+ KA Y K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA---AAYDKLE 1426
Query: 337 KYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRN 396
K + Q + + +D+D + ++ K + +DQ LA +
Sbjct: 1427 KTKNRLQQEL------DDLVVDLDNQRQLVSN----------LEKKQRKFDQLLAEEKNI 1470
Query: 397 KAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTL 456
+K+ ++ +A A + E SL + E K E+ +T K AE E L
Sbjct: 1471 SSKYADERDRAEAEA----REKETKALSLARALEEALEAKEELERTNKMLKAEMED---L 1523
Query: 457 LKTIIKVWKEMKSLREFQRFTNTPL---KLVLRKEKADQKADEEA--------------Y 499
+ + V K + L + +R T + K L + + + +A E+A +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 500 EAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 545
E ++QA E EE + +++ EY T L+ + R + A KKK
Sbjct: 1584 ERDLQAR-DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Score = 33.9 bits (76), Expect = 1.2
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 462 KVWKEMKSLREFQRFTNTPLKLVLRKEKADQ------KADEEAYEAEIQAEISELLEEHT 515
K+ KE K L E R ++ L +EKA K + E E++ + E +
Sbjct: 1003 KLSKERKLLEE--RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 516 EEYAQKME-------EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
E+ +K+E E LQ A K+Q AKK++ QAA DEIA+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Score = 33.5 bits (75), Expect = 1.6
Identities = 85/400 (21%), Positives = 152/400 (38%), Gaps = 69/400 (17%)
Query: 171 QEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRL 230
+ E E EE + K+ + EE+L+ +A L+ D ++ + L
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEAR-----LEEEEDRGQQLQAERKKMAQQML 960
Query: 231 QMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRL----- 285
+E ++ + + +K+ + + LEDE L + + ++E R+
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 286 -LMQDPERRWFGDDGRILALPNPIKPFPSRPPV-LTQEQSIKAELETLYKKAVKYVHSSQ 343
L ++ E+ + L N + S V L +E+ + ELE L +K
Sbjct: 1021 NLAEEEEKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL-------- 1067
Query: 344 HVIRSGDPPGNFQLDIDISGLIFT-HHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLT 402
GD + D+ I +E L A LA+L D+ Q+N A
Sbjct: 1068 ----EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---QKNNALKKI 1120
Query: 403 DKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKD--RTLLKTI 460
+L+ + +Q LD E+ ++ QK RD +E + +T L+
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQK---------------RDLGEELEALKTELEDT 1165
Query: 461 IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQ 520
+ + LR + T LK L +E ++EA++Q E +++AQ
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQ--------EMRQKHAQ 1210
Query: 521 KMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 560
+EE L+Q+K +A K KQ E+ D E
Sbjct: 1211 AVEELTEQLEQFKR----AKANLDKNKQTLEKENADLAGE 1246
Score = 32.0 bits (71), Expect = 4.7
Identities = 24/134 (17%), Positives = 64/134 (47%), Gaps = 2/134 (1%)
Query: 419 EKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 478
++ ++ ++ NE +E +K A Q+ +R + K+ + +++ +F +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS--KFKS 1821
Query: 479 TPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKV 538
T L + + +++ ++EA E + + + ++ +E ++E+ R +Q+K +
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 539 QRAKKKKRKQAAEE 552
A+ K+ K+ EE
Sbjct: 1882 GNARVKQLKRQLEE 1895
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,901,361
Number of Sequences: 37866
Number of extensions: 3112984
Number of successful extensions: 18403
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 441
Number of HSP's that attempted gapping in prelim test: 15149
Number of HSP's gapped (non-prelim): 2791
length of query: 1512
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1397
effective length of database: 13,892,928
effective search space: 19408420416
effective search space used: 19408420416
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.