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Search of human proteins with 19718734
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19718734 toll-like receptor 2 [Homo sapiens]
(784 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19718734 toll-like receptor 2 [Homo sapiens] 1571 0.0
gi|41350337 toll-like receptor 1 [Homo sapiens] 350 4e-96
gi|20143971 toll-like receptor 6 [Homo sapiens] 349 5e-96
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 347 2e-95
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 347 2e-95
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 189 7e-48
gi|20302168 toll-like receptor 8 [Homo sapiens] 176 1e-43
gi|7706093 toll-like receptor 7 [Homo sapiens] 169 1e-41
gi|4507531 toll-like receptor 3 [Homo sapiens] 140 6e-33
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 128 2e-29
gi|16751843 toll-like receptor 5 [Homo sapiens] 125 2e-28
gi|238908508 leucine-rich repeat and death domain-containing pro... 78 3e-14
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 76 1e-13
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 76 1e-13
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 72 2e-12
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 72 2e-12
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 72 3e-12
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 72 3e-12
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 69 2e-11
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 69 2e-11
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 68 3e-11
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 68 3e-11
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 68 3e-11
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 68 3e-11
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 68 3e-11
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 68 4e-11
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 68 4e-11
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 67 5e-11
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 67 6e-11
gi|198041768 synleurin [Homo sapiens] 67 6e-11
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 1571 bits (4069), Expect = 0.0
Identities = 784/784 (100%), Positives = 784/784 (100%)
Query: 1 MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS 60
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS
Sbjct: 1 MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLS 60
Query: 61 NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF 120
NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF
Sbjct: 61 NNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWF 120
Query: 121 KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE 180
KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE
Sbjct: 121 KPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELE 180
Query: 181 IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS 240
IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS
Sbjct: 181 IDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS 240
Query: 241 ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN
Sbjct: 241 ELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
Query: 301 DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK 360
DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK
Sbjct: 301 DRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK 360
Query: 361 SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI 420
SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
Sbjct: 361 SLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI 420
Query: 421 SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK 480
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK
Sbjct: 421 SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLK 480
Query: 481 ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE 540
ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE
Sbjct: 481 ELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCE 540
Query: 541 FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL 600
FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL
Sbjct: 541 FLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL 600
Query: 601 LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV 660
LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV
Sbjct: 601 LILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV 660
Query: 661 QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS 720
QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS
Sbjct: 661 QELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFS 720
Query: 721 HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA 780
HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA
Sbjct: 721 HFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRA 780
Query: 781 AIKS 784
AIKS
Sbjct: 781 AIKS 784
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 350 bits (897), Expect = 4e-96
Identities = 229/769 (29%), Positives = 399/769 (51%), Gaps = 49/769 (6%)
Query: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 98
S L +P L++ L++S N I+ + SD+ L+ L+++ N I ++ F
Sbjct: 32 SKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKF 91
Query: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 158
LE+LDLS+N L +S P +L L+L N + L F ++++L+ L +
Sbjct: 92 NQELEYLDLSHNKLVKISCH---PTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLST 148
Query: 159 MDTFTKIQRKDFAGLTFLEELEIDASDLQSY-EPKSLKSIQNVSHLILHM-----KQHIL 212
T +++ + L ++ ++Y E + + +Q+ + LH+ K+
Sbjct: 149 ----THLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHF 204
Query: 213 LLEIFVDVTSSVECLELR---DTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQV 269
+L++ V +++E ++ + + ++ S L+ +TN + T N++ T S ++
Sbjct: 205 ILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRI 264
Query: 270 MKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRL-----HIPRFYL 324
++L+ + + + L G +FR D ++ L+I ++ P+ Y+
Sbjct: 265 LQLVWHTT-VWYFSISNVKLQGQLDFRDFDYSGT----SLKALSIHQVVSDVFGFPQSYI 319
Query: 325 FYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED 384
+ S + +K TV ++ +V L + +LD S NL+ + +N
Sbjct: 320 YEIFSNM-----NIKNFTVSGTR--MVHMLCPSKISPFLHLDFSNNLLTDTVFENCG--- 369
Query: 385 AWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNS--FHSMPETCQWPEKMKYLN 442
L+TLIL+ N L L K E +K+L +DIS+NS + C W + + LN
Sbjct: 370 HLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLN 429
Query: 443 LSSTRI-HSVTGCIPKTLEILDVSNNNLNLFS---LNLPQLKELYISRNKLMTLPDASLL 498
+SS + ++ C+P +++LD+ +N + + L L+EL ++ N L LP
Sbjct: 430 MSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSF 489
Query: 499 PMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQE-QQALAKVLID 557
L VL I N+++ S + S +++++AG N F C+CE F + Q ++VL
Sbjct: 490 SSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEG 549
Query: 558 WPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWY 617
WP +Y CD P RG ++D +S C+ T L+ + + +L + LC WY
Sbjct: 550 WPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWY 609
Query: 618 MKMMWAWLQAKRKPRKAP----SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLC 673
++M+ W Q +R+ R P RN+ + AF+SYS D++WV+N ++ LE ++C
Sbjct: 610 LRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEG--MQIC 667
Query: 674 LHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAI 733
LH+R+F+PGK I++NII IEKS+K++FVLS NFV+SEWC YEL F+H LF E +++ I
Sbjct: 668 LHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLI 727
Query: 734 LILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
LILLEPI + +IP + KL+ +M +TYLEWP ++++R FW NLRAAI
Sbjct: 728 LILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 349 bits (896), Expect = 5e-96
Identities = 241/766 (31%), Positives = 398/766 (51%), Gaps = 47/766 (6%)
Query: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 98
S L +P L K LD+S N I + SD+ L L L+ N I ++ F
Sbjct: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKF 98
Query: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 158
LE+LDLS+N L +S P+ S L+L N +K L F +L++L L +
Sbjct: 99 NQDLEYLDLSHNQLQKISCH---PIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSA 155
Query: 159 MDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKS--LKSIQNVSHLILHMKQH---ILL 213
M K+Q+ D + L L DL++Y K +S+Q ++ LH+ H +
Sbjct: 156 M----KLQKLDLLPIAHLH-LSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFA 210
Query: 214 LEIFVDVTSSVECLELRDTDLDTFH-------FSELSTGETNSLIKKFTFRNVKITDESL 266
+++ + V +++ CL+L + L+ + SEL+ G T + FT +++ T + L
Sbjct: 211 IQVNISV-NTLGCLQLTNIKLNDDNCQVFIKFLSELTRGST---LLNFTLNHIETTWKCL 266
Query: 267 FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY 326
+V + L + L + T+ + + R + D ++ LTI HI +
Sbjct: 267 VRVFQFLWP-KPVEYLNIYNLTI--IESIR--EEDFTYSKTTLKALTIE--HITNQVFLF 319
Query: 327 DLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAW 386
+ LY++ + + + S + L + ++L+ ++N+ + + +
Sbjct: 320 SQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCS---TL 376
Query: 387 PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHS--MPETCQWPEKMKYLNLS 444
L+TLIL++N L L K G + +L +D+S NS S E C W E + LNLS
Sbjct: 377 VKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLS 436
Query: 445 STRI-HSVTGCIPKTLEILDVSNNNLNLFS---LNLPQLKELYISRNKLMTLPDASLLPM 500
S + SV C+P +++LD+ +N + + L L+EL ++ N L LP
Sbjct: 437 SNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSS 496
Query: 501 LLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQE-QQALAKVLIDWP 559
L VL I N+++ S + S +++++AG N F C+CE F + Q ++VL WP
Sbjct: 497 LSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWP 556
Query: 560 ANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMK 619
+Y CD P RG ++D +S C+ T L+ + + +L + LC WY++
Sbjct: 557 DSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLR 616
Query: 620 MMWAWLQAKRKPRKAP----SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLH 675
M+ W Q +R+ R P RN+ + AF+SYSE D+ WV++ +V LE + ++CLH
Sbjct: 617 MVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKED--IQICLH 674
Query: 676 KRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILI 735
+R+F+PGK I++NII+ IEKS+K++FVLS NFV+SEWC YEL F+H LF E ++ ILI
Sbjct: 675 ERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILI 734
Query: 736 LLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAA 781
LLEPI + +IP ++ KL+ +M +TYL+WP ++++R FW N+RAA
Sbjct: 735 LLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 347 bits (890), Expect = 2e-95
Identities = 238/785 (30%), Positives = 394/785 (50%), Gaps = 33/785 (4%)
Query: 13 VIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDL 72
+ S+ + L +R + S+ SL +P+ LT A +LDLS N + + +SD
Sbjct: 9 IFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDF 68
Query: 73 QRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132
L+ L+L N I ++ +F L +LDLS N L +++ W+ L+ L +L+L
Sbjct: 69 HSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVT--WYL-LAGLRYLDLS 125
Query: 133 GNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLE--ELEIDASDLQSYE 190
N + T+ +++ L+IL + KIQ+ DF + L + + L YE
Sbjct: 126 FNDFDTMPICEEAGNMSHLEILGLSG----AKIQKSDFQKIAHLHLNTVFLGFRTLPHYE 181
Query: 191 PKSLKSIQNVS-HLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS---ELSTGE 246
SL + H++L M + +L D + + LE+ + D + S + +
Sbjct: 182 EGSLPILNTTKLHIVLPMDTNFWVL--LRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSL 239
Query: 247 TNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDP 306
N+ V + + LF +++ + S + + + T G + D
Sbjct: 240 ENAKTSVLLLNKVDLLWDDLFLILQFVWHTS-VEHFQIRNVTFGGKAYLDHNSFD--YSN 296
Query: 307 GKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLD 366
+ T+ + +H FY+ D L ++ +T+ N++ + L + +YL+
Sbjct: 297 TVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQ--MPHMLFPNYPTKFQYLN 354
Query: 367 LSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSF- 425
+ N++ +E K + P L+TLIL N L +L L ++D+S+N
Sbjct: 355 FANNILTDELFKRTI---QLPHLKTLILNGNKLETLSLVS-CFANNTPLEHLDLSQNLLQ 410
Query: 426 HSMPETCQWPEKMKYLNLSSTRIH-SVTGCIPKTLEILDVSNNNLNLF---SLNLPQLKE 481
H E C WPE + +NLS ++ SV C+PK+++ILD++NN + +++L L+E
Sbjct: 411 HKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRE 470
Query: 482 LYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEF 541
L I+ N L LP S L VL I N I + S + + S +KTL AG N F C+CE
Sbjct: 471 LNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCEL 530
Query: 542 LSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLL 601
+F Q + +++ W +Y C+ P ++RG +++DV L C+ L+ + + +L
Sbjct: 531 KNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVL 590
Query: 602 ILLTGVLCHRFHGLWYMKMMW----AWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVEN 657
L C F WY++M+ W + ++ ++ RN+ + AF+SYSE D+ WV+N
Sbjct: 591 GLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKN 650
Query: 658 LMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYEL 717
++ LE + +CL++ F PGK I +NI+ IEKS+K++FVLS NFV++EWC YE
Sbjct: 651 ELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEF 710
Query: 718 DFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN 777
F+H LF EN+D ILILLEPI IP R+ KL+ ++ K YLEWP D + FW N
Sbjct: 711 YFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWAN 770
Query: 778 LRAAI 782
LRAAI
Sbjct: 771 LRAAI 775
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 347 bits (890), Expect = 2e-95
Identities = 238/785 (30%), Positives = 394/785 (50%), Gaps = 33/785 (4%)
Query: 13 VIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDL 72
+ S+ + L +R + S+ SL +P+ LT A +LDLS N + + +SD
Sbjct: 9 IFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDF 68
Query: 73 QRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132
L+ L+L N I ++ +F L +LDLS N L +++ W+ L+ L +L+L
Sbjct: 69 HSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVT--WYL-LAGLRYLDLS 125
Query: 133 GNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLE--ELEIDASDLQSYE 190
N + T+ +++ L+IL + KIQ+ DF + L + + L YE
Sbjct: 126 FNDFDTMPICEEAGNMSHLEILGLSG----AKIQKSDFQKIAHLHLNTVFLGFRTLPHYE 181
Query: 191 PKSLKSIQNVS-HLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS---ELSTGE 246
SL + H++L M + +L D + + LE+ + D + S + +
Sbjct: 182 EGSLPILNTTKLHIVLPMDTNFWVL--LRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSL 239
Query: 247 TNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDP 306
N+ V + + LF +++ + S + + + T G + D
Sbjct: 240 ENAKTSVLLLNKVDLLWDDLFLILQFVWHTS-VEHFQIRNVTFGGKAYLDHNSFD--YSN 296
Query: 307 GKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLD 366
+ T+ + +H FY+ D L ++ +T+ N++ + L + +YL+
Sbjct: 297 TVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQ--MPHMLFPNYPTKFQYLN 354
Query: 367 LSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSF- 425
+ N++ +E K + P L+TLIL N L +L L ++D+S+N
Sbjct: 355 FANNILTDELFKRTI---QLPHLKTLILNGNKLETLSLVS-CFANNTPLEHLDLSQNLLQ 410
Query: 426 HSMPETCQWPEKMKYLNLSSTRIH-SVTGCIPKTLEILDVSNNNLNLF---SLNLPQLKE 481
H E C WPE + +NLS ++ SV C+PK+++ILD++NN + +++L L+E
Sbjct: 411 HKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRE 470
Query: 482 LYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEF 541
L I+ N L LP S L VL I N I + S + + S +KTL AG N F C+CE
Sbjct: 471 LNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCEL 530
Query: 542 LSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLL 601
+F Q + +++ W +Y C+ P ++RG +++DV L C+ L+ + + +L
Sbjct: 531 KNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVL 590
Query: 602 ILLTGVLCHRFHGLWYMKMMW----AWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVEN 657
L C F WY++M+ W + ++ ++ RN+ + AF+SYSE D+ WV+N
Sbjct: 591 GLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKN 650
Query: 658 LMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYEL 717
++ LE + +CL++ F PGK I +NI+ IEKS+K++FVLS NFV++EWC YE
Sbjct: 651 ELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEF 710
Query: 718 DFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVN 777
F+H LF EN+D ILILLEPI IP R+ KL+ ++ K YLEWP D + FW N
Sbjct: 711 YFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWAN 770
Query: 778 LRAAI 782
LRAAI
Sbjct: 771 LRAAI 775
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 189 bits (481), Expect = 7e-48
Identities = 227/824 (27%), Positives = 349/824 (42%), Gaps = 143/824 (17%)
Query: 46 IPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHL 105
IP L + K+LDLS N + ++ + LQ L L+ I TIE+ ++ SL L L
Sbjct: 48 IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL 107
Query: 106 DLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKI 165
L+ N + +L+ F LSSL L + +L E HL L+ L V + +
Sbjct: 108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL-ENFPIGHLKTLKELNVAHNLIQSFK 166
Query: 166 QRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVE 225
+ F+ LT LE L++ ++ +QS L+ + + L L +
Sbjct: 167 LPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSL------------------ 208
Query: 226 CLELRDTDLDTFHFSELSTGETNSL-IKKFTFRNVKITDESLFQVMKLLNQISGLLELEF 284
D L+ +F + G + + K T RN + VMK I GL LE
Sbjct: 209 -----DLSLNPMNF--IQPGAFKEIRLHKLTLRN----NFDSLNVMKTC--IQGLAGLEV 255
Query: 285 DDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY------DLSTLYSLTERV 338
L G FR N D +E L L I F L Y D+ L++ V
Sbjct: 256 HRLVL---GEFRNEGNLEKFDKSALEGLC--NLTIEEFRLAYLDYYLDDIIDLFNCLTNV 310
Query: 339 KR-----ITVENSKVF----------LVPCLLSQH----LKSLEYLDLSENLMVEEYLKN 379
+T+E K F LV C Q LKSL+ L + N N
Sbjct: 311 SSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKG-----GN 365
Query: 380 SACEDAWPSLQTLILRQNHLA-----SLEKTGET------------------LLTLKNLT 416
+ E PSL+ L L +N L+ S G T L L+ L
Sbjct: 366 AFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLE 425
Query: 417 NIDISKNSFHSMPETCQWPE--KMKYLNLSSTRIHSVTGCI---PKTLEILDVSNNNL-- 469
++D ++ M E + + YL++S T I +LE+L ++ N+
Sbjct: 426 HLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQE 485
Query: 470 -----------NLFSLNLPQ----------------LKELYISRNKLMTLPDA--SLLPM 500
NL L+L Q L+ L +S N +L L
Sbjct: 486 NFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNS 545
Query: 501 LLVLKISRNAITTFSKEQLDSF-HTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWP 559
L VL S N I T K++L F +L L N+F C+CE SF Q + ++L++
Sbjct: 546 LQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE-V 604
Query: 560 ANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMK 619
C +PS +G V + ++ C + G+ L++ + VL ++F+ +++
Sbjct: 605 ERMECATPSDKQGMPVLSLNIT---CQMNKTIIGVSVLSVLVVSVVAVLVYKFY--FHLM 659
Query: 620 MMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDF 679
++ ++ R NI YDAFV YS +D WV N +V+ LE PPF+LCLH RDF
Sbjct: 660 LLAGCIKYGR------GENI-YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDF 712
Query: 680 IPGKWIIDNII-DSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLE 738
IPG I NII + KS K + V+S++F++S WC +E + + F + I I+L+
Sbjct: 713 IPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQ 772
Query: 739 PIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
+EK + Q+ +L ++++ TYLEW R FW LR A+
Sbjct: 773 KVEKTLLRQQ-VELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL 815
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 176 bits (445), Expect = 1e-43
Identities = 217/841 (25%), Positives = 343/841 (40%), Gaps = 124/841 (14%)
Query: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN------------ 86
S SL+ +P L +++ L LSN +I YIS D + +NL L L+ N
Sbjct: 209 SFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV 268
Query: 87 ------GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLG 140
IN I+ +F +L L +L+LS L ++++WFK + L L+L N +G
Sbjct: 269 PCDGGASIN-IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFN--YLVG 325
Query: 141 ETSLFSHLTKLQILRVGNMD--------------------------------TFTKIQRK 168
E + + LT L L + ++ F +++
Sbjct: 326 EIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELRED 385
Query: 169 DFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSV---- 224
DF L L L + + K QN S+L + + + D S
Sbjct: 386 DFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSS 445
Query: 225 ----ECLELRDTDLDT------FHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKL-L 273
+ R TD + +HF T LIK K D SL + +
Sbjct: 446 SFQRHIRKRRSTDFEFDPHSNFYHF-------TRPLIKPQCAAYGKALDLSLNSIFFIGP 498
Query: 274 NQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYS 333
NQ L ++ + + N + I K LT RL F + S L
Sbjct: 499 NQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD------FDNASALTE 552
Query: 334 LTERVKRITVENSKVFLVPCLLS-----QHLKSLEYLDLSEN---LMVEEYLKNSACEDA 385
L++ NS F + + Q+ +L+ L+LS N + ++Y S
Sbjct: 553 LSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESK---- 608
Query: 386 WPSLQTLILRQNHLASLEKTGETLLT-----LKNLTNIDISKNSFHSMPETC--QWPEKM 438
SL L+ N L L + LKNLT +D+S N +P P +
Sbjct: 609 --SLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASL 666
Query: 439 KYLNLSSTRIHSVTGCIPKT---LEILDVSNNNLNLFSLNLPQ----LKELYISRNKLMT 491
L+++ + + + LE+LD+ N L + +L L+ L +S N++
Sbjct: 667 TELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISH 726
Query: 492 LPDASL--LPMLLVLKISRNAITTFSKEQLDSFHTLKT--LEAGGNNFICSCEFLSFTQE 547
LP L + L L +S N + T +K L++ T K LE GN F C+C+ F +
Sbjct: 727 LPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRW 786
Query: 548 QQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGV 607
V I + +C SP RG+ + + L+ TA++ +++
Sbjct: 787 MDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAA 846
Query: 608 LCHRFHGLWYMKMMWAWLQAKRKP-RKAPSRNICYDAFVSYSERDAY---WVENLMVQEL 663
L H W + ++ AK K R + YDA++SY +DA WV N + L
Sbjct: 847 LAHHLF-YWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHL 905
Query: 664 ENFNPP-FKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHF 722
E LCL +RD+ PG IIDN++ SI +S KTVFVL++ + KS K +
Sbjct: 906 EESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQ 965
Query: 723 RLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREG-FWVNLRAA 781
RL DEN D I ILLEP+ + + ++ +LR+ + + L+WP D + EG FW LR
Sbjct: 966 RLMDENMDVIIFILLEPVLQHS---QYLRLRQRICKSSILQWP-DNPKAEGLFWQTLRNV 1021
Query: 782 I 782
+
Sbjct: 1022 V 1022
Score = 50.8 bits (120), Expect = 5e-06
Identities = 143/614 (23%), Positives = 234/614 (38%), Gaps = 114/614 (18%)
Query: 7 MVWVLGVIISLSKE---ESSNQASLSCDRNG-----ICKGSSGSLNSIPSGLTEAVKSLD 58
M+ + ++IS S E E + S CD I + S+ L +P + + V LD
Sbjct: 10 MLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELD 69
Query: 59 LSNNRITYISNSDLQRCVNLQALVLT---------------SNGINTIEEDSFSSLGSLE 103
LS+N IT+I+N Q NL + L SNG+N I + +F +L +L
Sbjct: 70 LSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLN-ITDGAFLNLKNLR 128
Query: 104 HLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFT 163
L L N L + S SLT L+L+ N + + + S L L+ L + F
Sbjct: 129 ELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITKEGI-SRLINLKNLYLAWNCYFN 184
Query: 164 KIQRKD------FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQ-------- 209
K+ K F LT LE L + + L PK S++ + +K
Sbjct: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKG 244
Query: 210 --HILLLEI-------FVDVTSSVECLELRDTDLDTFHFSELS----TGETNSLIKKFT- 255
++ LL++ F V C ++D F F L+ +++ ++K
Sbjct: 245 LINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINA 304
Query: 256 --FRNVKITDESLFQVMKLLNQISG------LLELEFDDCTLNGV-GNFRASDNDRVIDP 306
F+N+ + L+ +I+ L LE D + N + G++ N I
Sbjct: 305 AWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHIN---ISR 361
Query: 307 GKVETLTIRRLHIPRFYLFYDL--STLYSLTERVKRITVENSKVFL--VPCLLSQHLKSL 362
+ L++R LH+ R Y+F +L L + T+ F+ + L Q+ +L
Sbjct: 362 NFSKLLSLRALHL-RGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
Query: 363 EYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTN----- 417
E + LSEN + + +D S Q H+ T N +
Sbjct: 421 EIIYLSENRI------SPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPL 474
Query: 418 -----------IDISKNS-FHSMPETCQWPEKMKYLNLSSTRIHSVT-----GCIPKTLE 460
+D+S NS F P + + LNLS+ V IP ++
Sbjct: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPH-VK 533
Query: 461 ILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLD 520
LD++NN L+ + + + L L D +L + R A T E +
Sbjct: 534 YLDLTNNRLD------------FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ 581
Query: 521 SFHTLKTLEAGGNN 534
+F LK L NN
Sbjct: 582 NFTNLKVLNLSHNN 595
Score = 34.3 bits (77), Expect = 0.46
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 14/132 (10%)
Query: 413 KNLTNIDISKNSF-HSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNL 471
K +T +D+S N H E+ Q + + +NL+ P + +N LN+
Sbjct: 63 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP------GIQSNGLNI 116
Query: 472 FS---LNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTL 528
LNL L+EL + N+L +P + L L L + +N I +KE + LK L
Sbjct: 117 TDGAFLNLKNLRELLLEDNQLPQIP-SGLPESLTELSLIQNNIYNITKEGISRLINLKNL 175
Query: 529 EAGGN---NFIC 537
N N +C
Sbjct: 176 YLAWNCYFNKVC 187
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 169 bits (427), Expect = 1e-41
Identities = 217/780 (27%), Positives = 339/780 (43%), Gaps = 82/780 (10%)
Query: 50 LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDS--FSSLGSLEHLDL 107
LTE +K L L +N + ++ + LQ L L+ N + D+ L SL LDL
Sbjct: 289 LTE-LKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDL 347
Query: 108 SYNY-------LSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD 160
S+N+ NLS + F L SL L + G +K L +L S L LQ L V ++
Sbjct: 348 SFNFELQVYRASMNLSQA-FSSLKSLKILRIRGYVFKELKSFNL-SPLHNLQNLEVLDLG 405
Query: 161 T-FTKIQRKD-FAGLTFLEELEIDASDLQ-SYEPKSLKSIQNVSHLILHMKQHILLLEIF 217
T F KI F L+ +++ + + S + + N + + +L +
Sbjct: 406 TNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHY 465
Query: 218 VDVTSSVECLELRDTDLDTFHFSE--LSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
++ + +E G+T L K F VK +D +K LN
Sbjct: 466 FRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF-VKSSDFQHLSFLKCLNL 524
Query: 276 ISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLT 335
L+ TLNG F+ R +D + RL + F +L L L
Sbjct: 525 SGNLISQ-----TLNG-SEFQPLAELRYLD------FSNNRLDLLHSTAFEELHKLEVLD 572
Query: 336 ERVKRITVENSKVFLVPCL-----LSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQ 390
NS F + +++LK L+ L +++N + + E SL+
Sbjct: 573 ------ISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESE----SLR 622
Query: 391 TLILRQNHLASLEKTGET--LLTLKNLTNI---DISKNSFHSMPETC--QWPEKMKYLNL 443
TL R NHL L + G+ L KNL + DISKNS +P P +K L+L
Sbjct: 623 TLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSL 682
Query: 444 SSTRIHSVTG----CIPKTLEILDVSNNNLNLFSLNLPQ----LKELYISRNKLMTLPDA 495
+ + S + C+ K LE LD+S+N L L LK L + N++ +L
Sbjct: 683 AKNGLKSFSWKKLQCL-KNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKY 741
Query: 496 SLLP--MLLVLKISRNAITTFSKEQLDS--FHTLKTLEAGGNNFICSCEFLSFTQEQQAL 551
L L L +S N I K + LK L N F+C+C+ + F
Sbjct: 742 FLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHT 801
Query: 552 AKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVS---GMCCALFLLILLTGVL 608
+ + C P +GQ V + L E T L+ + +LFL++++T
Sbjct: 802 EVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASH 861
Query: 609 CHRFHGLWYMKMMWAWLQAKRKP-RKAPSRNICYDAFVSYSERD---AYWVENLMVQELE 664
+ F +WY+ + + +AK K ++ S + CYDAF+ Y +D WV +V +LE
Sbjct: 862 LY-FWDVWYI---YHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLE 917
Query: 665 NFNPP-FKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFR 723
+ F LCL +RD++PG+ +++N+ SI+ S KTVFV+++ + K+E K SH R
Sbjct: 918 DPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQR 977
Query: 724 LFDENNDAAILILLE-PIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
L DE D ILI LE P +K +F +LRK + + LEWP + FW L+ A+
Sbjct: 978 LMDEKVDVIILIFLEKPFQK----SKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNAL 1033
Score = 72.8 bits (177), Expect = 1e-12
Identities = 129/540 (23%), Positives = 228/540 (42%), Gaps = 76/540 (14%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
+K L L +N +T + L L L +N I I+ED F++L L+ LDLS
Sbjct: 206 LKVLSLKDNNVTAVPTVLPS---TLTELYLYNNMIAKIQEDDFNNLNQLQILDLS----G 258
Query: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGL 173
N + P N +P + + F LT+L++LR+ + ++ + + F +
Sbjct: 259 NCPRCYNAPFPCAPCKN--NSPLQI--PVNAFDALTELKVLRL-HSNSLQHVPPRWFKNI 313
Query: 174 TFLEELEIDASDL--QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVT------SSVE 225
L+EL++ + L + + K L + ++ L L + + ++++ S++
Sbjct: 314 NKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
Query: 226 CLELRD---TDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 282
L +R +L +F+ S L + ++ T +KI + S+F+ K L +++L
Sbjct: 374 ILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGT-NFIKIANLSMFKQFKRLK----VIDL 428
Query: 283 EFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYD--------------- 327
+ + +G + ++ E + +LH Y YD
Sbjct: 429 SVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLH----YFRYDKYARSCRFKNKEASF 484
Query: 328 LSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWP 387
+S S + + + + + +F V QHL L+ L+LS NL + + L S +
Sbjct: 485 MSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNL-ISQTLNGSEFQPL-A 542
Query: 388 SLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPE----TCQWPEKMKYL-- 441
L+ L N L L T L L +DIS NS + E + + +K L
Sbjct: 543 ELRYLDFSNNRLDLLHST--AFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK 600
Query: 442 ------NLSSTRIHSVTGCIPKTLEI----LDV-----SNNNLNLFSLNLPQLKELYISR 486
++SS+ ++ +TLE LDV N L LF NL +L+EL IS+
Sbjct: 601 LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFK-NLLKLEELDISK 659
Query: 487 NKLMTLPDA---SLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLS 543
N L LP + P L L +++N + +FS ++L L+TL+ N E LS
Sbjct: 660 NSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLS 719
Score = 56.2 bits (134), Expect = 1e-07
Identities = 87/363 (23%), Positives = 144/363 (39%), Gaps = 59/363 (16%)
Query: 37 KGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGIN-TIEEDS 95
K S S+ + ++LDLS N I ++ +SD Q L+ L L+ N I+ T+
Sbjct: 478 KNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSE 537
Query: 96 FSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILR 155
F L L +LD S N L L S+ F+ L L L++ N SH Q
Sbjct: 538 FQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN-----------SHY--FQSEG 584
Query: 156 VGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLE 215
+ +M FTK L L++L ++ +D+ S ++++S
Sbjct: 585 ITHMLNFTK-------NLKVLQKLMMNDNDISSSTSRTMES------------------- 618
Query: 216 IFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQ 275
S+ LE R LD G+ L F+N+ +E + K N
Sbjct: 619 ------ESLRTLEFRGNHLDVL----WREGDNRYL---QLFKNLLKLEE--LDISK--NS 661
Query: 276 ISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETL-TIRRLHIPRFYLFYDLSTLYSL 334
+S L FD N A + + K++ L + L + L L +
Sbjct: 662 LSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNC 721
Query: 335 TERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLIL 394
+ +K + ++N+++ + Q L YLDLS N ++ K S E+ +L+ L+L
Sbjct: 722 SRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN-KIQMIQKTSFPENVLNNLKMLLL 780
Query: 395 RQN 397
N
Sbjct: 781 HHN 783
Score = 39.7 bits (91), Expect = 0.011
Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 24/143 (16%)
Query: 358 HLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTN 417
+LKSL YLD ++ L + + L PSLQ L L N++ S+ K E L L N+
Sbjct: 128 YLKSL-YLDGNQLLEIPQGLP--------PSLQLLSLEANNIFSIRK--ENLTELANIEI 176
Query: 418 IDISKNSFHSMPETCQWP---------EKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNN 468
+ + +N ++ P + K+K L+L + +V +P TL L + NN
Sbjct: 177 LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNM 236
Query: 469 LNLFS----LNLPQLKELYISRN 487
+ NL QL+ L +S N
Sbjct: 237 IAKIQEDDFNNLNQLQILDLSGN 259
Score = 39.3 bits (90), Expect = 0.014
Identities = 42/154 (27%), Positives = 63/154 (40%), Gaps = 27/154 (17%)
Query: 405 TGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDV 464
T T LTL DIS SFH + + I C+P L
Sbjct: 65 TNTTNLTLTINHIPDISPASFHRLDHLVE--------------IDFRCNCVPIPLG---- 106
Query: 465 SNNNLNLFSLN--------LPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSK 516
S NN+ + L L LK LY+ N+L+ +P L P L +L + N I + K
Sbjct: 107 SKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQ-GLPPSLQLLSLEANNIFSIRK 165
Query: 517 EQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQA 550
E L ++ L G N + + ++S++ E+ A
Sbjct: 166 ENLTELANIEILYLGQNCYYRNPCYVSYSIEKDA 199
Score = 35.4 bits (80), Expect = 0.21
Identities = 29/109 (26%), Positives = 54/109 (49%), Gaps = 6/109 (5%)
Query: 24 NQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVL 83
N +LS +NG+ S L + + +++LDLS+N++T + +L+ L+L
Sbjct: 676 NLKNLSLAKNGLKSFSWKKLQCLKN-----LETLDLSHNQLTTVPERLSNCSRSLKNLIL 730
Query: 84 TSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132
+N I ++ + L +LDLS N + + + F P + L L +L
Sbjct: 731 KNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSF-PENVLNNLKML 778
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 140 bits (352), Expect = 6e-33
Identities = 195/839 (23%), Positives = 342/839 (40%), Gaps = 148/839 (17%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
+K L+L +N ++ +S+ C NL L L SN I I+ + F +L LDLS+N LS
Sbjct: 101 LKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLS 160
Query: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGL 173
+ L +L L L N K+Q L+ +D F
Sbjct: 161 STKLGTQVQLENLQELLLSNN---------------KIQALKSEELDIFAN--------- 196
Query: 174 TFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTD 233
+ L++LE+ ++ ++ + P +I + L L+ Q + +T + CLEL +T
Sbjct: 197 SSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQ------LGPSLTEKL-CLELANTS 249
Query: 234 LDTFHFS--ELSTGE---------TNSLIKKFTFRNVKITDESLFQVMKLL--------- 273
+ S +LST TN + ++ N+ + F + L
Sbjct: 250 IRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Query: 274 ------NQISGLLELEF--------------------DDCT---LNGVGNFRASDNDRVI 304
+ + GL + + DD + L + + DND
Sbjct: 310 IQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI-- 367
Query: 305 DPGKVETLTIRRLHIPRFYLFYDLSTLYSLTER---------VKRITVENSKVFLVPCLL 355
PG + +++ L ++L +LT + + + +K+ +
Sbjct: 368 -PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDA 426
Query: 356 SQHLKSLEYLDLSEN---------------------LMVEEYLKNSACEDAW-PSLQTLI 393
L LE LDL N L +YL+ + A PSLQ L+
Sbjct: 427 FSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLM 486
Query: 394 LRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRI---- 448
LR+ L +++ + L+NLT +D+S N+ ++ + + EK++ L+L +
Sbjct: 487 LRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLW 546
Query: 449 -HSVTG---CIPKTLEILDVSNNNLNLFS-------LNLPQLKELYISRNKLMTLPDASL 497
H+ G K L L + N N F +L +LK + + N L TLP AS+
Sbjct: 547 KHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLP-ASV 605
Query: 498 LPMLLVLK---ISRNAITTFSKEQLD-SFHTLKTLEAGGNNFICSCEFLS-FTQEQQALA 552
+ LK + +N IT+ K+ +F L L+ N F C+CE ++ F
Sbjct: 606 FNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETH 665
Query: 553 KVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVS--GMCCALFLLILLTGVLCH 610
+ + ++YLC++P H G V+ S C +A M LLI + VL
Sbjct: 666 TNIPELSSHYLCNTPPHYHGFPVR--LFDTSSCKDSAPFELFFMINTSILLIFIFIVLLI 723
Query: 611 RFHGLWYMKMMWAWLQAKR----KPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENF 666
F G W + W + R K + Y A++ ++ +D WV +E
Sbjct: 724 HFEG-WRISFYWN-VSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHF-SSMEKE 780
Query: 667 NPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCK-YELDFSHFRLF 725
+ K CL +RDF G + ++ I++SI++S K +FV++ + +K CK +++ + +
Sbjct: 781 DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAI 840
Query: 726 DENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS 784
++N D+ IL+ LE I + C R + + L WP+ + + F L+ A+ S
Sbjct: 841 EQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGS 899
Score = 36.2 bits (82), Expect = 0.12
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 8/91 (8%)
Query: 52 EAVKSLDLSNNRITYISNSD--------LQRCVNLQALVLTSNGINTIEEDSFSSLGSLE 103
E ++ LDL +N + + L+ +L L L SNG + I + F L L+
Sbjct: 530 EKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELK 589
Query: 104 HLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN 134
+DL N L+ L +S F SL LNL N
Sbjct: 590 IIDLGLNNLNTLPASVFNNQVSLKSLNLQKN 620
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 128 bits (322), Expect = 2e-29
Identities = 127/457 (27%), Positives = 213/457 (46%), Gaps = 48/457 (10%)
Query: 358 HLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLT----LK 413
HL++L +L L+ N + + C SL+ L N L + G+ L L
Sbjct: 573 HLRTLRHLSLAHN-NIHSQVSQQLCST---SLRALDFSGNALGHMWAEGDLYLHFFQGLS 628
Query: 414 NLTNIDISKNSFHSM-PETCQ-WPEKMKYLNLSSTRIHSVTGC----IPKTLEILDVSNN 467
L +D+S+N H++ P+T + P+ ++ L L + +PK LE+LD++ N
Sbjct: 629 GLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPK-LEVLDLAGN 687
Query: 468 NLN-LFSLNLP---QLKELYISRNKLMTLPDA--SLLPMLLVLKISRNAITTFSKEQLDS 521
L L + +LP +L+ L +S N + + S L L +S NA+ T
Sbjct: 688 QLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGP 747
Query: 522 FHT-LKTLEAGGNNFICSC--EFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQV--Q 576
+ L+ L+ N C+C F+ F E QA L P+ C SP ++G + Q
Sbjct: 748 LASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGL---PSRVKCGSPGQLQGLSIFAQ 804
Query: 577 DVRLSVSECHRTALVSGMCCALFLLILLTGV---LCHRFHG--LWY-MKMMWAWLQAKRK 630
D+RL + E +S C AL LL + G+ + H G LWY + AWL + +
Sbjct: 805 DLRLCLDEA-----LSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGR 859
Query: 631 PRKAPSRNICYDAFVSYSERD---AYWVENLMVQELENFNPPF--KLCLHKRDFIPGKWI 685
+ YDAFV + + A WV N + +LE + +LCL +RD++PGK +
Sbjct: 860 QSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTL 919
Query: 686 IDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAI 745
+N+ S+ S KT+FVL+ S + + RL ++ D +L++L P +++
Sbjct: 920 FENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRS- 978
Query: 746 PQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
R+ +LR+ + ++ L WP + + FW L A+
Sbjct: 979 --RYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013
Score = 54.7 bits (130), Expect = 3e-07
Identities = 133/541 (24%), Positives = 206/541 (38%), Gaps = 112/541 (20%)
Query: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN--------------- 86
+L +P L +++ L LS NRI ++ DL L+ L + N
Sbjct: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
Query: 87 -GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSL 144
+ D+FS L LE L L + LS L++SWF+ L +L L+L N YK + +T
Sbjct: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKA 329
Query: 145 FSHLTKLQILRVGNMDTFTKIQRKDFAGLTF---------LEELEIDASDLQSYEPKSLK 195
F LT+L+ L + +F +R FA L+ L+EL++ +S + +L+
Sbjct: 330 FQGLTQLRKLNL----SFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLR 385
Query: 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFT 255
+ L M Q + L F++ L F
Sbjct: 386 PLAR-----LPMLQTLRLQMNFIN-----------QAQLGIFR----------------A 413
Query: 256 FRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIR 315
F ++ D S N+ISG EL +G D + P V+T
Sbjct: 414 FPGLRYVDLS-------DNRISGASELTATMGEADGGEKVWLQPGD--LAPAPVDT---- 460
Query: 316 RLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEE 375
P F + + T + R N+ V + P + +Q L L+ L LS N + +
Sbjct: 461 ----PSSEDFRPNCSTLNFTLDLSR----NNLVTVQPEMFAQ-LSHLQCLRLSHNCISQA 511
Query: 376 YLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNS--------FHS 427
N + LQ L L N L + + L L +D+S NS H+
Sbjct: 512 V--NGSQFLPLTGLQVLDLSHNKLDLYHE--HSFTELPRLEALDLSYNSQPFGMQGVGHN 567
Query: 428 MPETCQWPEKMKYLNLSSTRIHSVTG--CIPKTLEILDVSNNNLN----------LFSLN 475
+++L+L+ IHS +L LD S N L F
Sbjct: 568 FSFVAHL-RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQG 626
Query: 476 LPQLKELYISRNKLMTLPDASL--LP-MLLVLKISRNAITTFSKEQLDSFHTLKTLEAGG 532
L L L +S+N+L TL +L LP L VL++ N + F L L+ L+ G
Sbjct: 627 LSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAG 686
Query: 533 N 533
N
Sbjct: 687 N 687
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/97 (30%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 57 LDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS 116
LDL+ N++ ++N L L+ L ++ N I+ + FS L L+LS N L +
Sbjct: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
Query: 117 SSWFKPL-SSLTFLNLLGNPYKTLGETSLFSHLTKLQ 152
SWF PL S+L L++ NP + L ++Q
Sbjct: 742 HSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQ 778
Score = 39.7 bits (91), Expect = 0.011
Identities = 132/568 (23%), Positives = 224/568 (39%), Gaps = 112/568 (19%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSN----GIN--------TIEEDSFSSLGS 101
V SL LS+NRI ++ +SD +L+ L L N G++ TIE +F ++ +
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
Query: 102 LEHLDLSYNYLSN--------------------LSSSWFKPLSSLTFLNLLGN------- 134
LE L+LSYN + L S+ L +L FL + GN
Sbjct: 125 LEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPC 184
Query: 135 -------PYKTLGETSL------FSHLT--------KLQILRVGNMDTFTKIQRKDFAGL 173
P LG +L +++LT L+ L + + + K+ +D A L
Sbjct: 185 RQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLL-SYNRIVKLAPEDLANL 243
Query: 174 TFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLL--EIFVDVTSSVECLELRD 231
T L L++ + + + + + +H L + F + S +E L L+D
Sbjct: 244 TALRVLDVGG---------NCRRCDHAPNPCMECPRHFPQLHPDTFSHL-SRLEGLVLKD 293
Query: 232 TDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNG 291
+ L + S G N R + +++ L++ + GL +L + + N
Sbjct: 294 SSLSWLNASWF-RGLGN-------LRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN- 344
Query: 292 VGNFRASDNDRVIDPGKVETLTIRRLHIPR-FYLFYDLSTLYSLTERVKRITVENSKVFL 350
R S + P + ++ L + F+ D +TL L T+ F+
Sbjct: 345 -YQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFI 403
Query: 351 VPCLLS--QHLKSLEYLDLSENL------MVEEYLKNSACEDAWPSLQTLILRQNHLASL 402
L + L Y+DLS+N + + E W L S
Sbjct: 404 NQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSS 463
Query: 403 EKTGETLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRI-HSVTGC--IPKT 458
E TL N T +D+S+N+ ++ PE ++ L LS I +V G +P T
Sbjct: 464 EDFRPNCSTL-NFT-LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLT 521
Query: 459 -LEILDVSNNNLNLFS----LNLPQLKELYISRNKL--------MTLPDASLLPMLLVLK 505
L++LD+S+N L+L+ LP+L+ L +S N + L L L
Sbjct: 522 GLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLS 581
Query: 506 ISRNAITTFSKEQLDSFHTLKTLEAGGN 533
++ N I + +QL S +L+ L+ GN
Sbjct: 582 LAHNNIHSQVSQQLCS-TSLRALDFSGN 608
Score = 39.3 bits (90), Expect = 0.014
Identities = 29/107 (27%), Positives = 48/107 (44%)
Query: 50 LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSY 109
L ++++ L L +N + + L L+ L L N + + S + L LD+S
Sbjct: 651 LPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSC 710
Query: 110 NYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156
N +S ++ +F L LNL N KT+ + + LQIL V
Sbjct: 711 NSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDV 757
Score = 32.0 bits (71), Expect = 2.3
Identities = 42/152 (27%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY----LS--------NLSSSWFKPLS 124
N+ +L L+SN I+ + + F+ L SL HL+L +N LS + S F +
Sbjct: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
Query: 125 SLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDAS 184
+L LNL N T+ +L L L + + T I D A L L L
Sbjct: 124 TLEELNLSYNNIMTV--PALPKSLISLSL-------SHTNILMLDSASLAGLHALRFLFM 174
Query: 185 DLQSY-----------EPKSLKSIQNVSHLIL 205
D Y P +L + N++HL L
Sbjct: 175 DGNCYYKNPCRQALEVAPGALLGLGNLTHLSL 206
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 125 bits (314), Expect = 2e-28
Identities = 198/830 (23%), Positives = 325/830 (39%), Gaps = 149/830 (17%)
Query: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGIN-TIEEDSFSSLG 100
+L +P L + L LS N I ++ S LQ L L S TI++++F +L
Sbjct: 37 NLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 95
Query: 101 SLEHLDLSYN---------------------YLSNLSSS-----WFKPLSSLTFLNLLGN 134
+L LDL + Y LS + +F+ L +LT L+L N
Sbjct: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155
Query: 135 PYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSL 194
++L F L L+ + + F + + LE L+ S SL
Sbjct: 156 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHE-------LEPLQGKTLSFFSLAANSL 208
Query: 195 KSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSE-LSTGETNSLI-- 251
S +V ++LEI +DV+ + +++ T +FS +S + SLI
Sbjct: 209 YSRVSVDWGKCMNPFRNMVLEI-LDVSGNGWTVDI------TGNFSNAISKSQAFSLILA 261
Query: 252 -----KKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVID- 305
F F N+K D++ F +GL L+ F S N RV +
Sbjct: 262 HHIMGAGFGFHNIKDPDQNTF---------AGLARSSVRHLDLS--HGFVFSLNSRVFET 310
Query: 306 --PGKVETLTIRRLHIPRFYLFYDLSTLYSLT-----------------ERVKRITVENS 346
KV L +++ FY L L L +V I ++ +
Sbjct: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370
Query: 347 KVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTG 406
+ ++ + L+ L+ LDL +N + + PS+ + L N L +L K
Sbjct: 371 HIAIIQDQTFKFLEKLQTLDLRDNALTTIHF--------IPSIPDIFLSGNKLVTLPKIN 422
Query: 407 ETL----LTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTG----CIPKT 458
T L+ L N+DI +P ++ L L+ R S +G +
Sbjct: 423 LTANLIHLSENRLENLDILYFLLR-VPH-------LQILILNQNRFSSCSGDQTPSENPS 474
Query: 459 LEILDVSNNNLNL---------FSLNLPQLKELYISRNKLMTLPDA--SLLPMLLVLKIS 507
LE L + N L L L L+ LY++ N L +LP S L L L ++
Sbjct: 475 LEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLN 534
Query: 508 RNAITTFSKEQL-------------------DSFHTLKTLEAGGNNFICSCEFLSFTQEQ 548
N +T S L D F +L L+ N FIC CE +F
Sbjct: 535 SNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWL 594
Query: 549 QALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFL-------L 601
+ PA+ C P G V LS C ++ + +LF+ L
Sbjct: 595 NHTNVTIAGPPADIYCVYPDSFSG--VSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTL 652
Query: 602 ILLTGVLCHRFHGLWYMKMMWAW-LQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMV 660
L+T + +F G ++ A L K P+ YDA++ +S +D WV+N ++
Sbjct: 653 FLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALL 712
Query: 661 QELE---NFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYEL 717
+ L+ + F LC +RDF+PG+ I NI D+I S K V ++S +F++ WC
Sbjct: 713 KHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAF 772
Query: 718 DFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMD 767
++ R + N A I++++ + + + + +R + + YL WP D
Sbjct: 773 SYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSIRGFVQKQQYLRWPED 821
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 78.2 bits (191), Expect = 3e-14
Identities = 150/615 (24%), Positives = 254/615 (41%), Gaps = 119/615 (19%)
Query: 11 LGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEA--VKSLDLSNNRITYIS 68
+G + EE+ Q L D + + G L P + + VK L L N+I
Sbjct: 122 VGEVSPQVSEENQKQLGLGADNFTVNLEAKG-LQEFPKDILKIKYVKYLYLDKNQIKTFQ 180
Query: 69 NSDLQRCVNLQALVLTSNGINTIEED----------------------SFSSLGSLEHLD 106
+D + L+ L L NG++++ + S LG++ L
Sbjct: 181 GADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLF 240
Query: 107 LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD-----T 161
NY+ N S + L +L L+L N + + +T L L+ LRV N++ T
Sbjct: 241 FYNNYIENFPSD-LECLGNLEILSLGKNKLRHIPDT-----LPSLKTLRVLNLEYNQLTT 294
Query: 162 FTKIQRKDFAGLTFLEEL-EID-ASDLQSYEPKSLKSIQNVSHLIL-HMKQHILLLEIFV 218
F K L FL +L +D +L S PK ++ ++N+ L++ H K L +EIF
Sbjct: 295 FPK-------ALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF- 346
Query: 219 DVTSSVECLELRDTDLDTFHFSELSTGETNSLI-KKFTFRNV-------------KITDE 264
++ L+L D L+ + E LI K +N+ ++D
Sbjct: 347 -QLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDN 405
Query: 265 SLFQVMKLLNQISGLLEL--------EFDDCT--LNGVGNFRASDNDRVIDPGKVETL-T 313
L ++ K +++++ L +L + DC LN + + S N P +++
Sbjct: 406 KLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQK 465
Query: 314 IRRLHIPRFYLFY------DLSTLY----------------SLTERVKRITVENSKVFLV 351
I ++ + + Y L +LY S ++++ + + +K+
Sbjct: 466 IIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLL-- 523
Query: 352 PCLLSQH---LKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGET 408
+ S+H L +L+YLDL +N + K A SL LIL N E
Sbjct: 524 --IFSEHFCSLINLKYLDLGKN----QIKKIPASISNMISLHVLILCCN---KFETFPRE 574
Query: 409 LLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTR-IH-SVTGCIPKTLEILDVSN 466
L TL+NL +D+S+N + + ++ LN SS + IH + C ++LE L++S
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQ 634
Query: 467 -NNLNLFSL-----NLPQLKELYISRNKLMTLP-DASLLPMLLVLKISRNAITTFSKEQL 519
L L N+ QLKEL IS N + +P + L L+ L N I ++ L
Sbjct: 635 IKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQI-SYLPPSL 693
Query: 520 DSFHTLKTLEAGGNN 534
S + L+ L GNN
Sbjct: 694 LSLNDLQQLNLSGNN 708
Score = 50.8 bits (120), Expect = 5e-06
Identities = 107/474 (22%), Positives = 202/474 (42%), Gaps = 50/474 (10%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
+K L L++N++ IS+ ++ L+ L+L N + I E S LE L LS N L+
Sbjct: 351 IKELQLADNKLEVISHK-IENFRELRILILDKNLLKNIPE-KISCCAMLECLSLSDNKLT 408
Query: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV-GNMDTFTKIQRKDFAG 172
L + L++L L++ N + T SHL + L GN+ T I+ K+
Sbjct: 409 ELPK-YIHKLNNLRKLHVNRNNMVKI--TDCISHLNNICSLEFSGNIITDVPIEIKNCQK 465
Query: 173 LTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDT 232
+ ++E+ + + Y P L ++ ++ +L ++ + EI VD++ S + L L +
Sbjct: 466 II---KIELSYNKIM-YFPLGLCALDSLYYLSVNGNY---ISEIPVDISFSKQLLHLELS 518
Query: 233 DLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGV 292
+ FSE SLI N+K D Q+ K+ IS ++ L N
Sbjct: 519 ENKLLIFSE----HFCSLI------NLKYLDLGKNQIKKIPASISNMISLHVLILCCNKF 568
Query: 293 GNFRAS----DNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKV 348
F +N +V+D + + I D+ L + ++++ +++
Sbjct: 569 ETFPRELCTLENLQVLDLSENQLQKISS----------DICNL----KGIQKLNFSSNQF 614
Query: 349 FLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKT-GE 407
P L Q L+SLE L++S+ + + + L+ L + N + + + GE
Sbjct: 615 IHFPIELCQ-LQSLEQLNISQ-IKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGE 672
Query: 408 TLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPK--TLEILDVS 465
L+NL ++ N +P + ++ LNLS + ++ I +L+ ++
Sbjct: 673 ----LRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFD 728
Query: 466 NNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQL 519
+N L + + + K+LY L + + + KI N IT + E L
Sbjct: 729 DNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFEFL 782
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 76.3 bits (186), Expect = 1e-13
Identities = 97/404 (24%), Positives = 178/404 (44%), Gaps = 31/404 (7%)
Query: 26 ASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTS 85
A SCD + S L ++P GL+ ++LD+S N IT + + L+ L L
Sbjct: 31 APCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAG 90
Query: 86 NGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLF 145
N ++ I + S L L+ L L N L + S + LS+L L L N ++ E S F
Sbjct: 91 NDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDS-F 149
Query: 146 SHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLIL 205
L +L+ L + + ++ T++ + L L+ L + + + S + ++ ++ L L
Sbjct: 150 EGLVQLRHLWLDD-NSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208
Query: 206 HMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDES 265
H + L + D ++E L+L +L F + + L F ++ + +
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKEL--GFHSNSISVIPDG 266
Query: 266 LFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLF 325
F LL I D L+ VG N + + +L IR + + F
Sbjct: 267 AFDGNPLLRTI------HLYDNPLSFVG------NSAFHNLSDLHSLVIRGASMVQ--QF 312
Query: 326 YDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDA 385
+L+ T ++ +T+ +K+ +P L Q K L LDLS N + + + C
Sbjct: 313 PNLTG----TVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN-NIRDLPSFNGCH-- 365
Query: 386 WPSLQTLILRQNHLASL-EKTGETLLTLKNLTNIDISKNSFHSM 428
+L+ + L++N + + E T + L++L+ L D+S+N H +
Sbjct: 366 --ALEEISLQRNQIYQIKEGTFQGLISLRIL---DLSRNLIHEI 404
Score = 48.1 bits (113), Expect = 3e-05
Identities = 54/208 (25%), Positives = 94/208 (45%), Gaps = 22/208 (10%)
Query: 339 KRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNH 398
+R+ + VP LS ++L+ + + E+ KN +P L+ L L N
Sbjct: 39 RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKN------FPFLEELQLAGND 92
Query: 399 LASLEKTGETLLTLKNLTNIDISKNSFHSMP-ETCQWPEKMKYLNLSSTRIHSVT----- 452
L+ + + L LK L + + N ++P E + ++ L L + I SV
Sbjct: 93 LSFIHP--KALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFE 150
Query: 453 GCIPKTLEILDVSNNNLNLFSL----NLPQLKELYISRNKLMTLPDASL--LPMLLVLKI 506
G + L L + +N+L + NLP L+ L ++ NK+ ++PD + L L+VL +
Sbjct: 151 GLVQ--LRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208
Query: 507 SRNAITTFSKEQLDSFHTLKTLEAGGNN 534
N I + S+ D L+TL+ NN
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/97 (29%), Positives = 54/97 (55%), Gaps = 4/97 (4%)
Query: 39 SSGSLNSIPS-GLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFS 97
S ++ +PS A++ + L N+I I Q ++L+ L L+ N I+ I +F+
Sbjct: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
Query: 98 SLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN 134
+LG + +LD+S+N L++ + + L+ L L L+GN
Sbjct: 411 TLGPITNLDVSFNELTSFPT---EGLNGLNQLKLVGN 444
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/250 (24%), Positives = 104/250 (41%), Gaps = 22/250 (8%)
Query: 336 ERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSL---QTL 392
+ +K +T++N+++ VP + L +L+ L L N + S ED++ L + L
Sbjct: 105 KELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHIT------SVPEDSFEGLVQLRHL 158
Query: 393 ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWP-EKMKYLNLSSTRIHSV 451
L N L E L L L + ++ N S+P+ + L+L + +I S+
Sbjct: 159 WLDDNSLT--EVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSL 216
Query: 452 TG-CIP--KTLEILDVSNNNLNLFSLN---LPQLKELYISRNKLMTLPDASL--LPMLLV 503
+ C LE LD++ NNL F LP LKEL N + +PD + P+L
Sbjct: 217 SQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRT 276
Query: 504 LKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFT--QEQQALAKVLIDWPAN 561
+ + N ++ + L +L G + + L+ T E L I N
Sbjct: 277 IHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPN 336
Query: 562 YLCDSPSHVR 571
LC +R
Sbjct: 337 NLCQEQKMLR 346
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/196 (29%), Positives = 97/196 (49%), Gaps = 8/196 (4%)
Query: 13 VIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDL 72
++ L+ + + SL RNGI K G+ + + ++ L+L +N +T ++ L
Sbjct: 229 IVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN-----MEELELEHNNLTRVNKGWL 283
Query: 73 QRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132
LQ L ++ N I I D++ L LDLSYN L+ L S F LS L LNL
Sbjct: 284 YGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLG 343
Query: 133 GNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQ--RKDFAGLTFLEELEIDASDLQSYE 190
N + + +F L+ LQ L + N + I+ + FAGLT L +L + + ++S
Sbjct: 344 DNRVTHIAD-GVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSIT 402
Query: 191 PKSLKSIQNVSHLILH 206
K+ ++++ HL L+
Sbjct: 403 KKAFIGLESLEHLDLN 418
Score = 68.6 bits (166), Expect = 2e-11
Identities = 109/421 (25%), Positives = 178/421 (42%), Gaps = 66/421 (15%)
Query: 20 EESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQ 79
E +SN LS N I + ++ +L P A++SLDLS+N I+ I S R + L+
Sbjct: 117 EPTSNITLLSLVHNIIPEINAQALQFYP-----ALESLDLSSNIISEIKTSSFPR-MQLK 170
Query: 80 ALVLTSNGINTIEEDSFSSL-GSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKT 138
L L++N I T+E F +L SL + L+ N +S + FK L L FL L N K
Sbjct: 171 YLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKI 229
Query: 139 LGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQ 198
+ E F L L+ L++ + +K++ F GL +EELE++ ++L L ++
Sbjct: 230 V-EGLTFQGLDSLRSLKM-QRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLR 287
Query: 199 NVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRN 258
+ L + + I D C L + DL ++
Sbjct: 288 MLQQLYVSQN---AIERISPDAWEF--CQRLSELDL--------------------SYNQ 322
Query: 259 VKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLH 318
+ DES F + LL + L L + T G FR N ++TL +R
Sbjct: 323 LTRLDESAFVGLSLLER----LNLGDNRVTHIADGVFRFLSN--------LQTLDLRNNE 370
Query: 319 IPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLK 378
I + D S ++ + ++ ++ +++ + L+SLE+LDL+ N ++
Sbjct: 371 IS--WAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM----- 423
Query: 379 NSACEDAWPSLQTLILRQNHLASLEKTGETLLT---LKNLTNIDISKNSFHSMPETCQWP 435
S+Q Q HL L +LL LK L + N HS+ +C P
Sbjct: 424 ---------SIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHP 474
Query: 436 E 436
E
Sbjct: 475 E 475
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/158 (25%), Positives = 74/158 (46%), Gaps = 11/158 (6%)
Query: 387 PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPE-KMKYLNLSS 445
P+ +L H E + L L ++D+S N + +T +P ++KYLNLS+
Sbjct: 118 PTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEI-KTSSFPRMQLKYLNLSN 176
Query: 446 TRIHSV-TGC---IPKTLEILDVSNNNLNLFS---LNLPQLKELYISRNKLMTLPDASL- 497
RI ++ GC + +L ++ ++ N +++ LP L+ L + RN++ + +
Sbjct: 177 NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQ 236
Query: 498 -LPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNN 534
L L LK+ RN I+ + ++ LE NN
Sbjct: 237 GLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274
Score = 33.1 bits (74), Expect = 1.0
Identities = 25/102 (24%), Positives = 53/102 (51%), Gaps = 4/102 (3%)
Query: 450 SVTGCIPKTLEILDVSNNNLNLFSLNLPQ--LKELYISRNKLMTLP-DASLLPMLLVLKI 506
+++G +P ILD S+N L+ ++++L L+E+ ++ N+L +P + +L +
Sbjct: 68 ALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSL 127
Query: 507 SRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQ 548
N I + + L + L++L+ +N I + SF + Q
Sbjct: 128 VHNIIPEINAQALQFYPALESLDL-SSNIISEIKTSSFPRMQ 168
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 72.0 bits (175), Expect = 2e-12
Identities = 113/450 (25%), Positives = 201/450 (44%), Gaps = 49/450 (10%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L+ +PS L+ LDLS N I+ + + L L+ L L N + I + +F+ L SL
Sbjct: 57 LSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSL 116
Query: 103 EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTF 162
+ L L N L ++ + + L SL L L N + + S FS L L+ L + + +
Sbjct: 117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDAN-HISYVPPSCFSGLHSLRHLWLDD-NAL 174
Query: 163 TKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTS 222
T+I + F L+ L+ + + + + + ++ ++ L LH + L + D
Sbjct: 175 TEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLH 234
Query: 223 SVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 282
S+E L+L +LD F + + L F N++ E F L+ +
Sbjct: 235 SLETLDLNYNNLDEFPTAIRTLSNLKEL--GFHSNNIRSIPEKAFV------GNPSLITI 286
Query: 283 EFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRIT 342
F D + VG ++ TLT+ + F DL+ T ++ +T
Sbjct: 287 HFYDNPIQFVGRSAFQHLP------ELRTLTLN--GASQITEFPDLTG----TANLESLT 334
Query: 343 VENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASL 402
+ +++ +P + L +L+ LDLS NL+ E+ S C+ LQ + LR N + +
Sbjct: 335 LTGAQISSLPQTVCNQLPNLQVLDLSYNLL-EDLPSFSVCQ----KLQKIDLRHNEIYEI 389
Query: 403 E-KTGETLLTLKNLTNIDISK------NSFHSMPETCQWPEKMKYLNLSSTRIHS--VTG 453
+ T + LL+L++L N+ +K N+F ++P + L+LSS + S +TG
Sbjct: 390 KVDTFQQLLSLRSL-NLAWNKIAIIHPNAFSTLPSLIK-------LDLSSNLLSSFPITG 441
Query: 454 CIPKTLEILDVSNNNL---NLFSLNLPQLK 480
L L ++ N+ + S N P+LK
Sbjct: 442 L--HGLTHLKLTGNHALQSLISSENFPELK 469
Score = 61.6 bits (148), Expect = 3e-09
Identities = 114/474 (24%), Positives = 188/474 (39%), Gaps = 77/474 (16%)
Query: 104 HLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFT 163
+LDLS N +S L + L L L L GN + + + F+ L L++L + N +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGA-FTGLYSLKVLMLQN-NQLR 127
Query: 164 KIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSS 223
+ + L L+ L +DA+ + P + ++ HL L L EI V S
Sbjct: 128 HVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNA---LTEIPVQAFRS 184
Query: 224 VECLELRDTDLDTFH-FSELSTGETNSLIKKFTFRN-VKITDESLFQVMKLLNQISGLLE 281
+ L+ L+ H + + G +SL+ N + + F GL
Sbjct: 185 LSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFD---------GLHS 235
Query: 282 LEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERV--- 338
LE D N + F P + TL+ + L + + + S+ E+
Sbjct: 236 LETLDLNYNNLDEF----------PTAIRTLSNLK------ELGFHSNNIRSIPEKAFVG 279
Query: 339 --KRITVE--NSKVFLVPCLLSQHLKSLEYLDLSENLMVEEY--LKNSACEDAWPSLQTL 392
IT+ ++ + V QHL L L L+ + E+ L +A +L++L
Sbjct: 280 NPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTA------NLESL 333
Query: 393 ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPE--TCQWPEKMKYLNLSSTRIHS 450
L ++SL +T L NL +D+S N +P CQ K++ ++L I+
Sbjct: 334 TLTGAQISSLPQT--VCNQLPNLQVLDLSYNLLEDLPSFSVCQ---KLQKIDLRHNEIYE 388
Query: 451 VTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNA 510
+ +D L+L SLNL K I N TLP L+ L +S N
Sbjct: 389 IK---------VDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPS------LIKLDLSSNL 433
Query: 511 ITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLC 564
+++F + H L L+ GN+ + S + E KV I+ P Y C
Sbjct: 434 LSSF---PITGLHGLTHLKLTGNHALQSL----ISSENFPELKV-IEMPYAYQC 479
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 72.0 bits (175), Expect = 2e-12
Identities = 60/179 (33%), Positives = 93/179 (51%), Gaps = 10/179 (5%)
Query: 28 LSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNG 87
L + N + + +SGSL GLT A+ L LSNN I I C L LVL+ N
Sbjct: 264 LHLEYNSLVEVNSGSLY----GLT-ALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNN 318
Query: 88 INTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYK-TLGETS-LF 145
+ ++E+S + L SL L LS+N +S+++ FK L SL L+L N T+ +TS F
Sbjct: 319 LTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAF 378
Query: 146 SHLTKLQILRV-GNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHL 203
S L L L + GN + ++ F+GL LE L + + ++S + + ++N+ L
Sbjct: 379 SGLDSLSKLTLFGN--KIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKEL 435
Score = 52.8 bits (125), Expect = 1e-06
Identities = 93/421 (22%), Positives = 174/421 (41%), Gaps = 80/421 (19%)
Query: 5 LWMVWV-LGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNR 63
LW++ + L + + + + A+ +C + + G G L ++P L +SL+LS N+
Sbjct: 21 LWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRG-LAALPGDLPSWTRSLNLSYNK 79
Query: 64 IT----------------YISNSDLQRCVNLQA-------LVLTSNGINTIEEDSFSSLG 100
++ Y++N++L +L A L L N I ++E +
Sbjct: 80 LSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYL 139
Query: 101 SLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMD 160
SLE LDLS N ++ + ++ F + LNL GN TL E F L++ + + +
Sbjct: 140 SLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTL-ELGAFDGLSRSLLTLRLSKN 198
Query: 161 TFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILH-------------- 206
T++ + F L L +L+++ + ++ E + + + ++ L L
Sbjct: 199 RITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWG 257
Query: 207 -MKQHILLLEI--FVDVTS-------SVECLELRDTDLDTFHFSELS-TGETNSLIKKFT 255
K H+L LE V+V S ++ L L + + H S + + L+ F
Sbjct: 258 LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFN 317
Query: 256 FRNVKITDESLFQVMKLL------NQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKV 309
++ +ESL ++ L N IS + E F G+ + R D D G +
Sbjct: 318 -NLTRLDEESLAELSSLSVLRLSHNSISHIAEGAF-----KGLRSLRVLDLDHNEISGTI 371
Query: 310 ETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSE 369
E D S +S + + ++T+ +K+ V L+ LE+L+L
Sbjct: 372 E----------------DTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGG 415
Query: 370 N 370
N
Sbjct: 416 N 416
Score = 40.8 bits (94), Expect = 0.005
Identities = 57/246 (23%), Positives = 96/246 (39%), Gaps = 52/246 (21%)
Query: 337 RVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVE-----------------EYLK- 378
R+ ++ + +++ L+ L Q L SLE L L N + + EY
Sbjct: 212 RLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL 271
Query: 379 ---NSACEDAWPSLQTLILRQNHLASLEKTG--------ETLLTLKNLTNIDISKNSFHS 427
NS +L L L N +A + + G E +L+ NLT +D
Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLD-------- 323
Query: 428 MPETCQWPEKMKYLNLSSTRI-HSVTGCIP--KTLEILDVSNNNLN--------LFSLNL 476
E+ + L LS I H G ++L +LD+ +N ++ FS L
Sbjct: 324 -EESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFS-GL 381
Query: 477 PQLKELYISRNKLMTLPDASL--LPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNN 534
L +L + NK+ ++ + L L L + NAI + + LK L ++
Sbjct: 382 DSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
Query: 535 FICSCE 540
F+C C+
Sbjct: 442 FLCDCQ 447
Score = 40.0 bits (92), Expect = 0.008
Identities = 50/171 (29%), Positives = 76/171 (44%), Gaps = 30/171 (17%)
Query: 374 EEYLKNSACEDAWPSLQ-------TLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH 426
E YL N+ A PSL +L L+ N + S+E G L +L +D+S N+
Sbjct: 96 EVYLNNNELT-AVPSLGAASSHVVSLFLQHNKIRSVE--GSQLKAYLSLEVLDLSLNNIT 152
Query: 427 SMPETCQWPE--KMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYI 484
+ TC +P +K LNL+ RI TLE+ + +L +L L
Sbjct: 153 EVRNTC-FPHGPPIKELNLAGNRIG--------TLELGAFDGLSRSLLTLRL-------- 195
Query: 485 SRNKLMTLP-DASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNN 534
S+N++ LP A LP L L ++RN I ++L+ L+ NN
Sbjct: 196 SKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNN 246
Score = 38.1 bits (87), Expect = 0.032
Identities = 32/126 (25%), Positives = 61/126 (48%), Gaps = 11/126 (8%)
Query: 17 LSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSL---DLSNNRITYI---SNS 70
L +E + +SLS + + S S++ I G + ++SL DL +N I+ ++
Sbjct: 322 LDEESLAELSSLS-----VLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG 376
Query: 71 DLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLN 130
+L L L N I ++ + +FS L LEHL+L N + ++ F + +L L+
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
Query: 131 LLGNPY 136
+ + +
Sbjct: 437 ISSDSF 442
Score = 35.4 bits (80), Expect = 0.21
Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 5/99 (5%)
Query: 441 LNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSL----NLPQLKELYISRNKLMTLPDAS 496
L+ + ++ G +P L++S N L+ +LP L+E+Y++ N+L +P
Sbjct: 52 LDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG 111
Query: 497 LLPMLLV-LKISRNAITTFSKEQLDSFHTLKTLEAGGNN 534
+V L + N I + QL ++ +L+ L+ NN
Sbjct: 112 AASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNN 150
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 71.6 bits (174), Expect = 3e-12
Identities = 56/176 (31%), Positives = 86/176 (48%), Gaps = 13/176 (7%)
Query: 57 LDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS 116
LDL N I + N C NL LV+ N IN + E++F+ L L+ LDL N + NL
Sbjct: 252 LDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLP 311
Query: 117 SSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFL 176
FK L L+ LNL NP + + + + F +L KL+ L + ++ + IQ++ F L L
Sbjct: 312 PLIFKDLKELSQLNLSYNPIQKI-QANQFDYLVKLKSLSLEGIE-ISNIQQRMFRPLMNL 369
Query: 177 EELEIDASDLQSYEP--KSLK----SIQNVSHLILHMKQHILLLEIFVDVTSSVEC 226
+ Y P +S K I ++ +L+ + Q +FV V S+V C
Sbjct: 370 SHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQ-----RVFVWVVSAVTC 420
Score = 55.5 bits (132), Expect = 2e-07
Identities = 49/175 (28%), Positives = 80/175 (45%), Gaps = 23/175 (13%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
++ L L NN+IT IS + +L L L+ N I ++ F L LE L + N+LS
Sbjct: 152 LQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLS 211
Query: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQIL-----RVGNMDTFT----- 163
+S F L+SL L L+ N L + L H+ +L L + N+ T
Sbjct: 212 RISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCS 271
Query: 164 ----KIQRKD---------FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLIL 205
+ RK+ FA L L+EL++ ++ +++ P K ++ +S L L
Sbjct: 272 NLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNL 326
Score = 40.0 bits (92), Expect = 0.008
Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 29/245 (11%)
Query: 251 IKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVE 310
++K +N KIT S++ + LN ++ L L + T G F D ++E
Sbjct: 152 LQKLYLQNNKITSISIY-AFRGLNSLTKLY-LSHNRITFLKPGVFE--------DLHRLE 201
Query: 311 TLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSEN 370
L I H+ R T Y L + + + N L L QH+ L +LDL N
Sbjct: 202 WLIIEDNHLSRI----SPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGN 257
Query: 371 LMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPE 430
+ L+N +L L++R+N + L + T L+ L +D+ N ++P
Sbjct: 258 HI--HNLRNLTFISC-SNLTVLVMRKNKINHLNE--NTFAPLQKLDELDLGSNKIENLPP 312
Query: 431 TC-QWPEKMKYLNLSSTRIHSVTG--------CIPKTLEILDVSNNNLNLFSLNLPQLKE 481
+ +++ LNLS I + +LE +++SN +F L L
Sbjct: 313 LIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFR-PLMNLSH 371
Query: 482 LYISR 486
+Y +
Sbjct: 372 IYFKK 376
Score = 36.6 bits (83), Expect = 0.092
Identities = 25/93 (26%), Positives = 41/93 (44%)
Query: 37 KGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 96
K LN + + LDL +N+I + + L L L+ N I I+ + F
Sbjct: 280 KNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQF 339
Query: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFL 129
L L+ L L +SN+ F+PL +L+ +
Sbjct: 340 DYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHI 372
Score = 33.9 bits (76), Expect = 0.60
Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 2/100 (2%)
Query: 77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPY 136
N+ A+ L N I + D F + L+ L L N ++++S F+ L+SLT L L N
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Query: 137 KTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFL 176
T + +F L +L+ L + + + ++I F GL L
Sbjct: 187 -TFLKPGVFEDLHRLEWLIIED-NHLSRISPPTFYGLNSL 224
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 71.6 bits (174), Expect = 3e-12
Identities = 53/163 (32%), Positives = 84/163 (51%), Gaps = 2/163 (1%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L ++P G+ + L+LS NRI ++ DL L+ L L+ N I +E +F++L L
Sbjct: 45 LTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRL 104
Query: 103 EHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTF 162
L L N L + F L +LT L+L N L + + F L L+ L VG+ D
Sbjct: 105 RVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYT-FQDLHSLRRLEVGDND-L 162
Query: 163 TKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLIL 205
+ R+ FAGL LEEL ++ +L + +SL ++++ L L
Sbjct: 163 VFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRL 205
Score = 55.5 bits (132), Expect = 2e-07
Identities = 78/344 (22%), Positives = 147/344 (42%), Gaps = 76/344 (22%)
Query: 302 RVIDPGKVETL-TIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLK 360
R ++PG + L + L + + + ++ R++ + + +++ L+P + L
Sbjct: 67 RCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLD 126
Query: 361 SLEYLDLSENLMVEEYLKNSACEDAWP-----------------------SLQTLILRQN 397
+L LDLSEN +V L + +D +L+ L L +
Sbjct: 127 NLTLLDLSENKLV--ILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERC 184
Query: 398 HLASLEKTGETL--------LTLKNLTNIDISKNSFHSMP-----ETCQWP-------EK 437
+L +L +GE+L L L++L + +F +P E WP
Sbjct: 185 NLTAL--SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGS 242
Query: 438 MKYLNLSSTRI-HSVTGCIPKT-------LEILDVSNNNLNLFSL----NLPQLKELYIS 485
++ LNL+S + H+ +P L L++S+N ++ +L +L+EL+++
Sbjct: 243 LRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLA 302
Query: 486 RNKLMTL-PDASL-LPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLS 543
L + P A L L + +L +S N ++T + S +TL+TL GN C C L
Sbjct: 303 GALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLW 362
Query: 544 FTQEQQALAKVLIDWPANY-----LCDSPSHVRGQQVQDVRLSV 582
Q ++ L N+ C +P+ VRG ++++ SV
Sbjct: 363 IVQRRKTL---------NFDGRLPACATPAEVRGDALRNLPDSV 397
Score = 40.0 bits (92), Expect = 0.008
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 11/112 (9%)
Query: 435 PEKMKYLNLSSTRIHSVT----GCIPKTLEILDVSNNNLNLFS----LNLPQLKELYISR 486
P + + L LS RI + +P LE LD+S N + NLP+L+ L +
Sbjct: 53 PAETRLLELSRNRIRCLNPGDLAALP-ALEELDLSENAIAHVEPGAFANLPRLRVLRLRG 111
Query: 487 NKLMTLPDA--SLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFI 536
N+L +P + L L +L +S N + H+L+ LE G N+ +
Sbjct: 112 NQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLV 163
Score = 38.1 bits (87), Expect = 0.032
Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 2/113 (1%)
Query: 74 RCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLG 133
R +NL +L +T I + + L L+LS+N +S + F+ L L L+L G
Sbjct: 244 RGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAG 303
Query: 134 NPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL 186
+ E F L ++++L + N + + ++ F + LE L +D + L
Sbjct: 304 -ALLAVVEPQAFLGLRQIRLLNLSN-NLLSTLEESTFHSVNTLETLRVDGNPL 354
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 68.9 bits (167), Expect = 2e-11
Identities = 139/632 (21%), Positives = 249/632 (39%), Gaps = 96/632 (15%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L +PS L ++LDLS N++ I S L L+ L L++N I+ ++ +F +L L
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL 99
Query: 103 EHLDLSYNYLSN---LSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNM 159
EHL L++N L+ LS+ PL +T L+L GN + L L L +
Sbjct: 100 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAE- 158
Query: 160 DTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVD 219
++ T++ R F + LE+L++ ++ L E + + + ++ H+ L +
Sbjct: 159 NSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT--------HLNLSRNSLT 210
Query: 220 VTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLN--QIS 277
S +LR DL T + T+ +++ KLL+ ++
Sbjct: 211 CISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--------KLLHFPDLA 262
Query: 278 GLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLF-YDLSTLYSLTE 336
L L + + + N + D E + L P LS L +L
Sbjct: 263 ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLD- 321
Query: 337 RVKRITVENSKVFLVPCLLSQHLKSLEYLDLSEN---------------LMVEEYLKNSA 381
+ +++ L+P +HL SL +L+LS N LM+ + L ++A
Sbjct: 322 ------LSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD-LSHNA 374
Query: 382 CED------AWPSLQTLILRQN-----------HLASLEKTG------------------ 406
E A SL+TL+L+ N +LASL++
Sbjct: 375 LETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 407 --ETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSST-RIHSVTGC---IPKTLE 460
+ +L ++ + N + + L+LSS + TG + +LE
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLE 494
Query: 461 ILDVSNNNLNLFSLNLP---QLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKE 517
+L + N L + ++LP LK L ++ N+L LP + L VL + N+ +
Sbjct: 495 VLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGS 554
Query: 518 QLDSFHT-LKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQ 576
+ T L+ L GN C Q Q +V +D + +C S ++V
Sbjct: 555 AMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQ--GRVDVDATQDLICRFSSQ---EEVS 609
Query: 577 DVRLSVSECHRTALVSGMCCALFLLILLTGVL 608
+ +C + L + + IL++ +L
Sbjct: 610 LSHVRPEDCEKGGLKNINLIIILTFILVSAIL 641
Score = 46.6 bits (109), Expect = 9e-05
Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 39 SSGSLNSIPSGLTEAVKSLDLSNNRI-TYISNSDLQRCVNLQALVLTSNGINTIEEDSFS 97
S+G L +P V SLDLS N + + + L +L L L N + + +F
Sbjct: 116 SAGGLGPLPR-----VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
Query: 98 SLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSL 144
+ +LE LDL N L ++ F+ L LT LNL N + + SL
Sbjct: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSL 217
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 68.9 bits (167), Expect = 2e-11
Identities = 139/632 (21%), Positives = 249/632 (39%), Gaps = 96/632 (15%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L +PS L ++LDLS N++ I S L L+ L L++N I+ ++ +F +L L
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHL 99
Query: 103 EHLDLSYNYLSN---LSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNM 159
EHL L++N L+ LS+ PL +T L+L GN + L L L +
Sbjct: 100 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAE- 158
Query: 160 DTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVD 219
++ T++ R F + LE+L++ ++ L E + + + ++ H+ L +
Sbjct: 159 NSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT--------HLNLSRNSLT 210
Query: 220 VTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLN--QIS 277
S +LR DL T + T+ +++ KLL+ ++
Sbjct: 211 CISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--------KLLHFPDLA 262
Query: 278 GLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLF-YDLSTLYSLTE 336
L L + + + N + D E + L P LS L +L
Sbjct: 263 ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLD- 321
Query: 337 RVKRITVENSKVFLVPCLLSQHLKSLEYLDLSEN---------------LMVEEYLKNSA 381
+ +++ L+P +HL SL +L+LS N LM+ + L ++A
Sbjct: 322 ------LSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD-LSHNA 374
Query: 382 CED------AWPSLQTLILRQN-----------HLASLEKTG------------------ 406
E A SL+TL+L+ N +LASL++
Sbjct: 375 LETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 407 --ETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSST-RIHSVTGC---IPKTLE 460
+ +L ++ + N + + L+LSS + TG + +LE
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLE 494
Query: 461 ILDVSNNNLNLFSLNLP---QLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKE 517
+L + N L + ++LP LK L ++ N+L LP + L VL + N+ +
Sbjct: 495 VLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGS 554
Query: 518 QLDSFHT-LKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQ 576
+ T L+ L GN C Q Q +V +D + +C S ++V
Sbjct: 555 AMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQ--GRVDVDATQDLICRFSSQ---EEVS 609
Query: 577 DVRLSVSECHRTALVSGMCCALFLLILLTGVL 608
+ +C + L + + IL++ +L
Sbjct: 610 LSHVRPEDCEKGGLKNINLIIILTFILVSAIL 641
Score = 46.6 bits (109), Expect = 9e-05
Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 39 SSGSLNSIPSGLTEAVKSLDLSNNRI-TYISNSDLQRCVNLQALVLTSNGINTIEEDSFS 97
S+G L +P V SLDLS N + + + L +L L L N + + +F
Sbjct: 116 SAGGLGPLPR-----VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
Query: 98 SLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSL 144
+ +LE LDL N L ++ F+ L LT LNL N + + SL
Sbjct: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSL 217
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 8/181 (4%)
Query: 27 SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN 86
SL RNG+ K G+ + + ++ L L +N +T I+ L + LQ L L+ N
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSN-----MEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 297
Query: 87 GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS 146
IN I D++ L LDL++N+LS L S F LS L L++ N + + + F
Sbjct: 298 AINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCA-FR 356
Query: 147 HLTKLQILRVGNMDTFTKIQRKD--FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLI 204
L+ L+ L + N + I+ + F+GL L L + + ++S K+ + + HL
Sbjct: 357 GLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLD 416
Query: 205 L 205
L
Sbjct: 417 L 417
Score = 59.7 bits (143), Expect = 1e-08
Identities = 79/379 (20%), Positives = 156/379 (41%), Gaps = 68/379 (17%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEE--------- 93
L +P L V LDLS+NR+++I S + +L+ + L +N + TI
Sbjct: 65 LARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANIT 124
Query: 94 --------------DSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 139
+ SLE LDLS N +S L +++ P L +L L N ++
Sbjct: 125 LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSM 182
Query: 140 GETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQN 199
E F +L ++ N + + I K F L L+ LE++ + +++ + + + +
Sbjct: 183 -EPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGA 240
Query: 200 VSHLILHMKQHILLLEIFVDVTSSVECLELRDTD--------------LDTFHFSELSTG 245
+ L + L++ S++E L+L + L H S+ +
Sbjct: 241 LKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAIN 300
Query: 246 ETNSLIKKF---------TFRNVKITDESLFQVMKLLN--QISGLLELEFDDCTLNGVGN 294
+ +F TF ++ D+S F + LLN I DC G+ +
Sbjct: 301 RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS 360
Query: 295 FRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCL 354
++TL ++ I + D++ +S ++++R+ ++ +++ +
Sbjct: 361 --------------LKTLDLKNNEIS--WTIEDMNGAFSGLDKLRRLILQGNRIRSITKK 404
Query: 355 LSQHLKSLEYLDLSENLMV 373
L +LE+LDLS+N ++
Sbjct: 405 AFTGLDALEHLDLSDNAIM 423
Score = 47.8 bits (112), Expect = 4e-05
Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 32/283 (11%)
Query: 35 ICKGSSGSLNSIPSGLTEA--VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIE 92
+ K + +++IP + + ++ L+L+ N+I + Q L++L + NG+ +
Sbjct: 196 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255
Query: 93 EDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQ 152
+ +F L ++E L L +N L+ ++ W L L L+L N + + + KL
Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA-WEFCQKLS 314
Query: 153 ILRVGNMDTFTKIQRKD---FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQ 209
L + TF + R D F GL+ L L I + + + + + ++ L L
Sbjct: 315 ELDL----TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN- 369
Query: 210 HILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKK-FT----FRNVKITDE 264
+++ ++E + + LD L S+ KK FT ++ ++D
Sbjct: 370 ---------EISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 420
Query: 265 SL-------FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
++ F MK L Q+ DC L + + A +N
Sbjct: 421 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENN 463
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/132 (27%), Positives = 70/132 (53%), Gaps = 16/132 (12%)
Query: 392 LILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSV 451
L L N L+ ++ + ++ L++L + ++ N ++P + L+L+ RI +
Sbjct: 79 LDLSHNRLSFIKAS--SMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEI 136
Query: 452 TGCIPK------TLEILDVSNNNLNLFSLNLP--QLKELYISRNKLMTLPDA---SLLPM 500
+P+ +LE LD+S+NN++ P QLK LY++ N++ ++ +L
Sbjct: 137 ---LPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANT 193
Query: 501 LLVLKISRNAIT 512
LLVLK++RN I+
Sbjct: 194 LLVLKLNRNRIS 205
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 7/111 (6%)
Query: 429 PETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLN----LPQLKELYI 484
P TC+ + L+ S R+ + +P + LD+S+N L+ + L L+E+ +
Sbjct: 48 PTTCRCLGDL--LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
Query: 485 SRNKLMTLPDASLLPM-LLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNN 534
+ N+L T+P+ + + +L ++ N I E L F +L+TL+ NN
Sbjct: 106 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNN 156
Score = 42.7 bits (99), Expect = 0.001
Identities = 96/451 (21%), Positives = 170/451 (37%), Gaps = 93/451 (20%)
Query: 105 LDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTK 164
LDLS+N LS + +S L SL + L N +T+ S
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS----------------AN 122
Query: 165 IQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSV 224
I AG +E L + QS E L S N+S L ++
Sbjct: 123 ITLLSLAGNRIVEILPEHLKEFQSLETLDLSS-NNISEL-----------------QTAF 164
Query: 225 ECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEF 284
L+L+ L++ + + G ++L T +K+ + + + ++ L LE
Sbjct: 165 PALQLKYLYLNSNRVTSMEPGYFDNLAN--TLLVLKLNRNRISAIPPKMFKLPQLQHLEL 222
Query: 285 DDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFY--LFYDLSTLYSLTERVKRIT 342
+ + V D G +++L ++R + + F+ LS + L +T
Sbjct: 223 NRNKIKNV------DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276
Query: 343 VENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASL 402
E +K +L L+ L+ L LS+N + N DAW Q
Sbjct: 277 -EITKGWLYGLLM------LQELHLSQNAI------NRISPDAWEFCQ------------ 311
Query: 403 EKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPK---TL 459
K E LT +L+ +D S S+ T L++ + R+ + C + +L
Sbjct: 312 -KLSELDLTFNHLSRLDDSSFLGLSLLNT---------LHIGNNRVSYIADCAFRGLSSL 361
Query: 460 EILDVSNNNLN--------LFSLNLPQLKELYISRNKLMTLPDASL--LPMLLVLKISRN 509
+ LD+ NN ++ FS L +L+ L + N++ ++ + L L L +S N
Sbjct: 362 KTLDLKNNEISWTIEDMNGAFS-GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 420
Query: 510 AITTFSKEQLDSFHTLKTLEAGGNNFICSCE 540
AI + L+ L ++ +C C+
Sbjct: 421 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQ 451
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 8/181 (4%)
Query: 27 SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN 86
SL RNG+ K G+ + + ++ L L +N +T I+ L + LQ L L+ N
Sbjct: 183 SLKMQRNGVTKLMDGAFWGLSN-----MEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 237
Query: 87 GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS 146
IN I D++ L LDL++N+LS L S F LS L L++ N + + + F
Sbjct: 238 AINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCA-FR 296
Query: 147 HLTKLQILRVGNMDTFTKIQRKD--FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLI 204
L+ L+ L + N + I+ + F+GL L L + + ++S K+ + + HL
Sbjct: 297 GLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLD 356
Query: 205 L 205
L
Sbjct: 357 L 357
Score = 54.3 bits (129), Expect = 4e-07
Identities = 74/364 (20%), Positives = 150/364 (41%), Gaps = 68/364 (18%)
Query: 58 DLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEE-----------------------D 94
DLS+NR+++I S + +L+ + L +N + TI +
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 95 SFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQIL 154
SLE LDLS N +S L +++ P L +L L N ++ E F +L ++
Sbjct: 80 HLKEFQSLETLDLSSNNISELQTAF--PALQLKYLYLNSNRVTSM-EPGYFDNLANTLLV 136
Query: 155 RVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLL 214
N + + I K F L L+ LE++ + +++ + + + + + L + L+
Sbjct: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 215 EIFVDVTSSVECLELRDTD--------------LDTFHFSELSTGETNSLIKKF------ 254
+ S++E L+L + L H S+ + + +F
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 255 ---TFRNVKITDESLFQVMKLLN--QISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKV 309
TF ++ D+S F + LLN I DC G+ + +
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS--------------L 301
Query: 310 ETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSE 369
+TL ++ I + D++ +S ++++R+ ++ +++ + L +LE+LDLS+
Sbjct: 302 KTLDLKNNEIS--WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359
Query: 370 NLMV 373
N ++
Sbjct: 360 NAIM 363
Score = 47.8 bits (112), Expect = 4e-05
Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 32/283 (11%)
Query: 35 ICKGSSGSLNSIPSGLTEA--VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIE 92
+ K + +++IP + + ++ L+L+ N+I + Q L++L + NG+ +
Sbjct: 136 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 93 EDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQ 152
+ +F L ++E L L +N L+ ++ W L L L+L N + + + KL
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA-WEFCQKLS 254
Query: 153 ILRVGNMDTFTKIQRKD---FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQ 209
L + TF + R D F GL+ L L I + + + + + ++ L L
Sbjct: 255 ELDL----TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN- 309
Query: 210 HILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKK-FT----FRNVKITDE 264
+++ ++E + + LD L S+ KK FT ++ ++D
Sbjct: 310 ---------EISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDN 360
Query: 265 SL-------FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDN 300
++ F MK L Q+ DC L + + A +N
Sbjct: 361 AIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENN 403
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/130 (26%), Positives = 69/130 (53%), Gaps = 16/130 (12%)
Query: 394 LRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTG 453
L N L+ ++ + ++ L++L + ++ N ++P + L+L+ RI +
Sbjct: 21 LSHNRLSFIKAS--SMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEI-- 76
Query: 454 CIPK------TLEILDVSNNNLNLFSLNLP--QLKELYISRNKLMTLPDA---SLLPMLL 502
+P+ +LE LD+S+NN++ P QLK LY++ N++ ++ +L LL
Sbjct: 77 -LPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 135
Query: 503 VLKISRNAIT 512
VLK++RN I+
Sbjct: 136 VLKLNRNRIS 145
Score = 41.2 bits (95), Expect = 0.004
Identities = 95/450 (21%), Positives = 169/450 (37%), Gaps = 93/450 (20%)
Query: 106 DLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKI 165
DLS+N LS + +S L SL + L N +T+ S I
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS----------------ANI 63
Query: 166 QRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVE 225
AG +E L + QS E L S N+S L ++
Sbjct: 64 TLLSLAGNRIVEILPEHLKEFQSLETLDLSS-NNISEL-----------------QTAFP 105
Query: 226 CLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFD 285
L+L+ L++ + + G ++L T +K+ + + + ++ L LE +
Sbjct: 106 ALQLKYLYLNSNRVTSMEPGYFDNLAN--TLLVLKLNRNRISAIPPKMFKLPQLQHLELN 163
Query: 286 DCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFY--LFYDLSTLYSLTERVKRITV 343
+ V D G +++L ++R + + F+ LS + L +T
Sbjct: 164 RNKIKNV------DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT- 216
Query: 344 ENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLE 403
E +K +L L+ L+ L LS+N + N DAW Q
Sbjct: 217 EITKGWLYGLLM------LQELHLSQNAI------NRISPDAWEFCQ------------- 251
Query: 404 KTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPK---TLE 460
K E LT +L+ +D S S+ T L++ + R+ + C + +L+
Sbjct: 252 KLSELDLTFNHLSRLDDSSFLGLSLLNT---------LHIGNNRVSYIADCAFRGLSSLK 302
Query: 461 ILDVSNNNLN--------LFSLNLPQLKELYISRNKLMTLPDASL--LPMLLVLKISRNA 510
LD+ NN ++ FS L +L+ L + N++ ++ + L L L +S NA
Sbjct: 303 TLDLKNNEISWTIEDMNGAFS-GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 361
Query: 511 ITTFSKEQLDSFHTLKTLEAGGNNFICSCE 540
I + L+ L ++ +C C+
Sbjct: 362 IMSLQGNAFSQMKKLQQLHLNTSSLLCDCQ 391
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 68.2 bits (165), Expect = 3e-11
Identities = 89/356 (25%), Positives = 153/356 (42%), Gaps = 22/356 (6%)
Query: 1 MPHTLWMVW------VLGVIISLSKEESSNQASLSC-DRNGICKGSSGSLNSIPSGLTEA 53
MP L W VLG ++S S + S DR +C ++P G+
Sbjct: 15 MPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKR--FVAVPEGIPTE 72
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
+ LDL NRI ++ + +L+ L L N ++ +E +F++L +L L L N L
Sbjct: 73 TRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK 132
Query: 114 NLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGL 173
+ F LS+LT L++ N L + +F L L+ L VG+ D I + F+GL
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLD-YMFQDLYNLKSLEVGDND-LVYISHRAFSGL 190
Query: 174 TFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTD 233
LE+L ++ +L S ++L + LI+ +H+ + I + L++
Sbjct: 191 NSLEQLTLEKCNLTSIPTEALSHLHG---LIVLRLRHLNINAIRDYSFKRLYRLKV---- 243
Query: 234 LDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVG 293
L+ H+ L T N L ++ IT +L V L + L+ L F + + N +
Sbjct: 244 LEISHWPYLDTMTPNCLY-GLNLTSLSITHCNLTAVPYL--AVRHLVYLRFLNLSYNPIS 300
Query: 294 NFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVF 349
S ++ +++ L +L + Y F L+ L L ++T VF
Sbjct: 301 TIEGSMLHELLRLQEIQ-LVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVF 355
Score = 43.5 bits (101), Expect = 8e-04
Identities = 50/183 (27%), Positives = 76/183 (41%), Gaps = 29/183 (15%)
Query: 48 SGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDL 107
SGL +++ L L +T I L L L L IN I + SF L L+ L++
Sbjct: 188 SGLN-SLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEI 246
Query: 108 SY-NYLSNLSSSWF-----------------------KPLSSLTFLNLLGNPYKTLGETS 143
S+ YL ++ + + L L FLNL NP T+ E S
Sbjct: 247 SHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTI-EGS 305
Query: 144 LFSHLTKLQILR-VGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSH 202
+ L +LQ ++ VG ++ F GL +L L + + L + E S+ N+
Sbjct: 306 MLHELLRLQEIQLVGGQ--LAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLET 363
Query: 203 LIL 205
LIL
Sbjct: 364 LIL 366
Score = 42.7 bits (99), Expect = 0.001
Identities = 91/440 (20%), Positives = 165/440 (37%), Gaps = 112/440 (25%)
Query: 149 TKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMK 208
T+ ++L +G + + + +FA LEELE++ + + + EP + ++ N+ L L
Sbjct: 71 TETRLLDLGK-NRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSN 129
Query: 209 QHILL-LEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLF 267
+ L+ L +F +++ T LD SE
Sbjct: 130 RLKLIPLGVFTGLSNL--------TKLD---ISE-------------------------- 152
Query: 268 QVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYD 327
N+I LL+ F D L + + DND L Y
Sbjct: 153 ------NKIVILLDYMFQD--LYNLKSLEVGDND----------------------LVYI 182
Query: 328 LSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED-AW 386
+S ++++T+E + +P HL L L L +L +A D ++
Sbjct: 183 SHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRL-------RHLNINAIRDYSF 235
Query: 387 PSLQTL-ILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETC-QWPEKMKYLNLS 444
L L +L +H L+ L NLT++ I+ + ++P + +++LNLS
Sbjct: 236 KRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLS 295
Query: 445 STRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASL--LPMLL 502
I ++ G + L +L+E+ + +L + + L L
Sbjct: 296 YNPISTIEGSMLH-----------------ELLRLQEIQLVGGQLAVVEPYAFRGLNYLR 338
Query: 503 VLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANY 562
VL +S N +TT + S L+TL N C C L + + W N+
Sbjct: 339 VLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRR---------WRLNF 389
Query: 563 -----LCDSPSHVRGQQVQD 577
C +P V+G++ +D
Sbjct: 390 NRQQPTCATPEFVQGKEFKD 409
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/275 (26%), Positives = 119/275 (43%), Gaps = 13/275 (4%)
Query: 21 ESSNQASLSCDRNGICKGSSGSLNSIP-------SGLTEAVKSLDLSNNRITYISNSDLQ 73
ES A + + +G +G S NSI +GL + + L L +N I+ + Q
Sbjct: 48 ESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIW-LYLDHNYISSVDEDAFQ 106
Query: 74 RCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLG 133
L+ L+L+SN I + +F + +L +LDLSYN L L S FK L L L+L
Sbjct: 107 GIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRS 166
Query: 134 NPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKS 193
N KT+ +F L L +G + + R FAGL L+EL ++ +
Sbjct: 167 NSLKTV-PIRVFQDCRNLDFLDLG-YNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAH 224
Query: 194 LKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKK 253
+ N+ + L + + + SS+ L+L D+ E T + ++K
Sbjct: 225 FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGI---EPGTFKCLPNLQK 281
Query: 254 FTFRNVKITDESLFQVMKLLNQISGLLELEFDDCT 288
+ K+T+ S V ++ IS L +C+
Sbjct: 282 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 68.2 bits (165), Expect = 3e-11
Identities = 72/275 (26%), Positives = 119/275 (43%), Gaps = 13/275 (4%)
Query: 21 ESSNQASLSCDRNGICKGSSGSLNSIP-------SGLTEAVKSLDLSNNRITYISNSDLQ 73
ES A + + +G +G S NSI +GL + + L L +N I+ + Q
Sbjct: 48 ESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIW-LYLDHNYISSVDEDAFQ 106
Query: 74 RCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLG 133
L+ L+L+SN I + +F + +L +LDLSYN L L S FK L L L+L
Sbjct: 107 GIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRS 166
Query: 134 NPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKS 193
N KT+ +F L L +G + + R FAGL L+EL ++ +
Sbjct: 167 NSLKTV-PIRVFQDCRNLDFLDLG-YNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAH 224
Query: 194 LKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKK 253
+ N+ + L + + + SS+ L+L D+ E T + ++K
Sbjct: 225 FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGI---EPGTFKCLPNLQK 281
Query: 254 FTFRNVKITDESLFQVMKLLNQISGLLELEFDDCT 288
+ K+T+ S V ++ IS L +C+
Sbjct: 282 LNLDSNKLTNISQETVNAWISLISITLSGNMWECS 316
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 67.8 bits (164), Expect = 4e-11
Identities = 53/183 (28%), Positives = 81/183 (44%), Gaps = 26/183 (14%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L+ +P L LDL NN+IT I + D + NL AL+L +N I+ + +F+ L L
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKL 131
Query: 103 EHLDLSYNYLSNLSSSW---------------------FKPLSSLTFLNLLGNPYKTLG- 140
E L LS N L L F L+ + + L NP K+ G
Sbjct: 132 ERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGI 191
Query: 141 ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNV 200
E F + KL +R+ + + T I + LT EL +D + + + SLK + N+
Sbjct: 192 ENGAFQGMKKLSYIRIADTN-ITSIPQGLPPSLT---ELHLDGNKISRVDAASLKGLNNL 247
Query: 201 SHL 203
+ L
Sbjct: 248 AKL 250
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/74 (29%), Positives = 39/74 (52%)
Query: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101
++ SIP GL ++ L L N+I+ + + L+ NL L L+ N I+ ++ S ++
Sbjct: 211 NITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 270
Query: 102 LEHLDLSYNYLSNL 115
L L L N L+ +
Sbjct: 271 LRELHLDNNKLTRV 284
Score = 34.7 bits (78), Expect = 0.35
Identities = 44/180 (24%), Positives = 69/180 (38%), Gaps = 39/180 (21%)
Query: 345 NSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEK 404
N+K+ V L LE L LS+N + E E +LQ L +N + + K
Sbjct: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKE------LPEKMPKTLQELRAHENEITKVRK 167
Query: 405 TGETLLTLKNLTNIDISKNSFHSMP---ETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEI 461
T L + I++ N S Q +K+ Y+ ++ T I S+ +P +L
Sbjct: 168 V--TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE 225
Query: 462 LDVSNNNL------------NLFSL----------------NLPQLKELYISRNKLMTLP 493
L + N + NL L N P L+EL++ NKL +P
Sbjct: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 457 KTLEILDVSNNNLNLFSLN----LPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAIT 512
K L L + NN ++ S L +L+ LY+S+N+L LP+ + L L+ N IT
Sbjct: 105 KNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE-KMPKTLQELRAHENEIT 163
Query: 513 TFSKEQLDSFHTLKTLEAGGN 533
K + + + +E G N
Sbjct: 164 KVRKVTFNGLNQMIVIELGTN 184
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 67.8 bits (164), Expect = 4e-11
Identities = 53/183 (28%), Positives = 81/183 (44%), Gaps = 26/183 (14%)
Query: 43 LNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSL 102
L+ +P L LDL NN+IT I + D + NL AL+L +N I+ + +F+ L L
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKL 131
Query: 103 EHLDLSYNYLSNLSSSW---------------------FKPLSSLTFLNLLGNPYKTLG- 140
E L LS N L L F L+ + + L NP K+ G
Sbjct: 132 ERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGI 191
Query: 141 ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNV 200
E F + KL +R+ + + T I + LT EL +D + + + SLK + N+
Sbjct: 192 ENGAFQGMKKLSYIRIADTN-ITSIPQGLPPSLT---ELHLDGNKISRVDAASLKGLNNL 247
Query: 201 SHL 203
+ L
Sbjct: 248 AKL 250
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/74 (29%), Positives = 39/74 (52%)
Query: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGS 101
++ SIP GL ++ L L N+I+ + + L+ NL L L+ N I+ ++ S ++
Sbjct: 211 NITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 270
Query: 102 LEHLDLSYNYLSNL 115
L L L N L+ +
Sbjct: 271 LRELHLDNNKLTRV 284
Score = 34.7 bits (78), Expect = 0.35
Identities = 44/180 (24%), Positives = 69/180 (38%), Gaps = 39/180 (21%)
Query: 345 NSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEK 404
N+K+ V L LE L LS+N + E E +LQ L +N + + K
Sbjct: 114 NNKISKVSPGAFTPLVKLERLYLSKNQLKE------LPEKMPKTLQELRAHENEITKVRK 167
Query: 405 TGETLLTLKNLTNIDISKNSFHSMP---ETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEI 461
T L + I++ N S Q +K+ Y+ ++ T I S+ +P +L
Sbjct: 168 V--TFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTE 225
Query: 462 LDVSNNNL------------NLFSL----------------NLPQLKELYISRNKLMTLP 493
L + N + NL L N P L+EL++ NKL +P
Sbjct: 226 LHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVP 285
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 457 KTLEILDVSNNNLNLFSLN----LPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAIT 512
K L L + NN ++ S L +L+ LY+S+N+L LP+ + L L+ N IT
Sbjct: 105 KNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPE-KMPKTLQELRAHENEIT 163
Query: 513 TFSKEQLDSFHTLKTLEAGGN 533
K + + + +E G N
Sbjct: 164 KVRKVTFNGLNQMIVIELGTN 184
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 67.4 bits (163), Expect = 5e-11
Identities = 53/208 (25%), Positives = 97/208 (46%), Gaps = 8/208 (3%)
Query: 36 CKGSSGSLNSIPSGLTEAVKSLD------LSNNRITYISNSDLQRCVNLQALVLTSNGIN 89
C G S NS+ K L+ L +N I+ I + L+ L+L+SN I+
Sbjct: 63 CLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRIS 122
Query: 90 TIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLT 149
++F + +L +LDLSYN L +L S F+ L L L+L N +T+ +F
Sbjct: 123 YFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTI-PVRIFQDCR 181
Query: 150 KLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQ 209
L++L +G + + R FAG+ L+EL ++ + + ++ +L L +
Sbjct: 182 NLELLDLG-YNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNK 240
Query: 210 HILLLEIFVDVTSSVECLELRDTDLDTF 237
++ + SS++ L+L +++ F
Sbjct: 241 ISVIGQTMSWTWSSLQRLDLSGNEIEAF 268
Score = 47.0 bits (110), Expect = 7e-05
Identities = 59/262 (22%), Positives = 105/262 (40%), Gaps = 70/262 (26%)
Query: 389 LQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTR 447
L+ LIL N ++ T + NL N+D+S N HS+ E + K+ L+L S
Sbjct: 111 LKELILSSNRISYF--LNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNS 168
Query: 448 IHSVTGCI---PKTLEILDVSNNNLNLFSLN----LPQLKELYISRN-----------KL 489
+ ++ I + LE+LD+ N + + N + +LKEL++ N +L
Sbjct: 169 LRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRL 228
Query: 490 MTLPDASL----------------------------------------LPMLLVLKISRN 509
++L + L +P L L + N
Sbjct: 229 VSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSN 288
Query: 510 AITTFSKEQLDSFHTLKTLEAGGNNFICS---CEFLSFTQEQQALAKVLIDWPANYLCDS 566
+T +E LDS+ +L + GN + CS C +++ + + L + I +C S
Sbjct: 289 KLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTI------ICAS 342
Query: 567 PSHVRGQQVQDVRLSVSECHRT 588
P ++G V D + S C ++
Sbjct: 343 PKELQGVNVIDAVKNYSICGKS 364
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/120 (29%), Positives = 58/120 (48%), Gaps = 3/120 (2%)
Query: 40 SGSLNSIPSGLTEAVKSL---DLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSF 96
S SL +IP + + ++L DL NRI ++ + + L+ L L N + + F
Sbjct: 166 SNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALF 225
Query: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156
L SL++L L +N +S + + SSL L+L GN + S+F + LQ L +
Sbjct: 226 PRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNL 285
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/189 (29%), Positives = 95/189 (50%), Gaps = 12/189 (6%)
Query: 20 EESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQ 79
E S+ S+SC R L +IP G+ K LDLS NR+ ++ + L+
Sbjct: 33 ECSAQNKSVSCHRR--------RLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLE 84
Query: 80 ALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 139
+ L+ N I +E +F++L +L L L N L + F LS+LT L++ N L
Sbjct: 85 EIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVIL 144
Query: 140 GETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQN 199
+ +F L L+ L VG+ D I + F+GL LE+L ++ +L + ++L +++
Sbjct: 145 LD-YMFQDLHNLKSLEVGDND-LVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRS 202
Query: 200 VSHLILHMK 208
+ + LH+K
Sbjct: 203 L--ISLHLK 209
Score = 49.7 bits (117), Expect = 1e-05
Identities = 75/328 (22%), Positives = 132/328 (40%), Gaps = 51/328 (15%)
Query: 304 IDPGKVETL-TIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSL 362
++PG L +R L + L +++ + ++ + +K+ ++ + Q L +L
Sbjct: 96 VEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155
Query: 363 EYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISK 422
+ L++ +N +V Y+ + A SL+ L L + +L ++ E L L++L ++ +
Sbjct: 156 KSLEVGDNDLV--YISHRAFSGLL-SLEQLTLEKCNLTAVPT--EALSHLRSLISLHLKH 210
Query: 423 NSFHSMP-------------ETCQWP-------EKMKYLNLSS-----TRIHSVTGCIPK 457
+ ++MP E WP + LNL+S T + +V K
Sbjct: 211 LNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFK 270
Query: 458 TLEILDVSNNNLNLFSL-------NLPQLKELYISRNKLMTLPDASL--LPMLLVLKISR 508
L L N + N S +L +L+EL+I +L T+ S L L VL +S+
Sbjct: 271 HLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQ 330
Query: 509 NAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPS 568
N + T + S L+ L N C C L Q Q L +C P
Sbjct: 331 NLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQ----FGGQQPMCAGPD 386
Query: 569 HVRGQQVQDVRLSVSECHRTALVSGMCC 596
+R + +D H TAL C
Sbjct: 387 TIRERSFKDF-------HSTALSFYFTC 407
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/199 (26%), Positives = 91/199 (45%), Gaps = 27/199 (13%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLS 113
+KSL++ +N + YIS+ ++L+ L L + + ++ S L SL L L + ++
Sbjct: 155 LKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNIN 214
Query: 114 NLSSSWFKPLSSLTFLN---------LLGNPYKTLGETSL--------------FSHLTK 150
N+ FK L L L + N L TSL F HL
Sbjct: 215 NMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVY 274
Query: 151 LQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQH 210
L L + + + + I+ F+ L L+EL I + L++ EP S + ++ + +L++ Q+
Sbjct: 275 LTHLNL-SYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLR--VLNVSQN 331
Query: 211 ILLLEIFVDVTSSVECLEL 229
LL + +V SS LE+
Sbjct: 332 -LLETLEENVFSSPRALEV 349
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/111 (29%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
Query: 76 VNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135
+NL +L +T+ ++T+ +F L L HL+LSYN +S + + F L L L+++G
Sbjct: 249 LNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQ 308
Query: 136 YKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL 186
+T+ E F L L++L V + + ++ F+ LE L I+ + L
Sbjct: 309 LRTI-EPHSFQGLRFLRVLNV-SQNLLETLEENVFSSPRALEVLSINNNPL 357
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 67.0 bits (162), Expect = 6e-11
Identities = 52/187 (27%), Positives = 94/187 (50%), Gaps = 3/187 (1%)
Query: 53 AVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYL 112
+V+ L+L NR+T + + V L+ L L++N I I E F L +L L L N L
Sbjct: 157 SVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNL 216
Query: 113 SNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAG 172
+ + S+ F+ L SL L+L NP + + + F L L+ L + N + R F+G
Sbjct: 217 TKVPSNAFEVLKSLRRLSLSHNPIEAI-QPFAFKGLANLEYLLLKN-SRIRNVTRDGFSG 274
Query: 173 LTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILL-LEIFVDVTSSVECLELRD 231
+ L+ L + +DL++ + ++N+ +L L + I + + F ++ +S++ L L
Sbjct: 275 INNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF 334
Query: 232 TDLDTFH 238
+L H
Sbjct: 335 NNLTALH 341
Score = 64.7 bits (156), Expect = 3e-10
Identities = 55/193 (28%), Positives = 91/193 (47%), Gaps = 33/193 (17%)
Query: 14 IISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSL---DLSNNRITYISNS 70
I+ +S+ + +L+C G S +L +PS E +KSL LS+N I I
Sbjct: 192 ILRISESGFQHLENLACLYLG-----SNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPF 246
Query: 71 DLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLN 130
+ NL+ L+L ++ I + D FS + +L+HL LS+N L NL+S F L +L +L
Sbjct: 247 AFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLK 306
Query: 131 LLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYE 190
L N +I+ + N DTF + L+ L + ++L +
Sbjct: 307 LDRN-----------------RIISIDN-DTFENMGAS-------LKILNLSFNNLTALH 341
Query: 191 PKSLKSIQNVSHL 203
P+ LK + ++ HL
Sbjct: 342 PRVLKPLSSLIHL 354
Score = 60.5 bits (145), Expect = 6e-09
Identities = 76/322 (23%), Positives = 129/322 (40%), Gaps = 55/322 (17%)
Query: 5 LWMVWVLGVIISLSKE--ESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNN 62
L++V +++ L KE S+ L R C+ L+SIP E+ L L+ N
Sbjct: 13 LFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLG--LSSIPKNFPESTVFLYLTGN 70
Query: 63 RITYISNSDLQRCVNLQA------------------------LVLTSNGINTIEEDSFSS 98
I+YI+ S+L +L A L L +N I ++ F
Sbjct: 71 NISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKG 130
Query: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLG------------------ 140
L +L +L L YN +S + F L S+ +LNL N LG
Sbjct: 131 LLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNN 190
Query: 141 -----ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLK 195
S F HL L L +G+ + TK+ F L L L + + +++ +P + K
Sbjct: 191 NILRISESGFQHLENLACLYLGS-NNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
Query: 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFT 255
+ N+ +L+L + + ++++ L L DL+ + S + +K
Sbjct: 250 GLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDR 309
Query: 256 FRNVKI---TDESLFQVMKLLN 274
R + I T E++ +K+LN
Sbjct: 310 NRIISIDNDTFENMGASLKILN 331
Score = 50.8 bits (120), Expect = 5e-06
Identities = 78/321 (24%), Positives = 132/321 (41%), Gaps = 84/321 (26%)
Query: 304 IDPGKVE-TLTIRRLH--------IPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCL 354
+DPG + L +R L+ +PR +F DL ++ L + R+TV S F+
Sbjct: 123 LDPGIFKGLLNLRNLYLQYNQVSFVPRG-VFNDLVSVQYLNLQRNRLTVLGSGTFV---- 177
Query: 355 LSQHLKSLEYLDLSENLMVE------EYLKNSACEDAWPSLQTLILRQNHLASLEKTGET 408
+ +L LDLS N ++ ++L+N AC L L N+L +
Sbjct: 178 ---GMVALRILDLSNNNILRISESGFQHLENLAC---------LYLGSNNLTKVPSNAFE 225
Query: 409 LLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNN 467
+L K+L + +S N ++ P + ++YL L ++RI +VT
Sbjct: 226 VL--KSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTR-------------- 269
Query: 468 NLNLFSLNLPQLKELYISRNKLMTLPDA--SLLPMLLVLKISRNAITTFSKEQLD----- 520
+ FS + LK L +S N L L SLL L+ LK+ RN I + + +
Sbjct: 270 --DGFS-GINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGAS 326
Query: 521 ------SFHTLKT--------------LEAGGNNFICSCEFLSFTQEQQALAKVLIDWPA 560
SF+ L L+A N + C+C+ L + A L
Sbjct: 327 LKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITL----- 381
Query: 561 NYLCDSPSHVRGQQVQDVRLS 581
N C +P +RG+ ++ + ++
Sbjct: 382 NIYCQNPPSMRGRALRYINIT 402
Score = 49.3 bits (116), Expect = 1e-05
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLG-SLEHLDLSYNYL 112
+K L LS+N + +++ NL L L N I +I+ D+F ++G SL+ L+LS+N L
Sbjct: 278 LKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNL 337
Query: 113 SNLSSSWFKPLSSLTFLNLLGNPYK 137
+ L KPLSSL L NP++
Sbjct: 338 TALHPRVLKPLSSLIHLQANSNPWE 362
Score = 35.0 bits (79), Expect = 0.27
Identities = 49/172 (28%), Positives = 72/172 (41%), Gaps = 23/172 (13%)
Query: 361 SLEYLDLSE----NLMVEEYLKNSACEDAWPS-------LQTLILRQNHLASLEKTGETL 409
++ Y++ SE + +V YL NS +P L L L N + L+
Sbjct: 71 NISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPG--IF 128
Query: 410 LTLKNLTNIDISKNSFHSMPE-TCQWPEKMKYLNLSSTRIH---SVTGCIPKTLEILDVS 465
L NL N+ + N +P ++YLNL R+ S T L ILD+S
Sbjct: 129 KGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLS 188
Query: 466 NNNLNLFS----LNLPQLKELYISRNKLMTLPDAS--LLPMLLVLKISRNAI 511
NNN+ S +L L LY+ N L +P + +L L L +S N I
Sbjct: 189 NNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPI 240
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,582,943
Number of Sequences: 37866
Number of extensions: 1175079
Number of successful extensions: 4810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 3075
Number of HSP's gapped (non-prelim): 1172
length of query: 784
length of database: 18,247,518
effective HSP length: 110
effective length of query: 674
effective length of database: 14,082,258
effective search space: 9491441892
effective search space used: 9491441892
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.