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Search of human proteins with 19557702
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19557702 surfeit 6 [Homo sapiens]
(361 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19557702 surfeit 6 [Homo sapiens] 698 0.0
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 75 9e-14
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 71 2e-12
gi|148746195 trichohyalin [Homo sapiens] 70 3e-12
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 67 2e-11
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 63 4e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 63 4e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 62 6e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 62 8e-10
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 61 2e-09
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 60 3e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 60 3e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 60 3e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 60 3e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 60 3e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 60 3e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 60 3e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 60 3e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 60 3e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 60 4e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 4e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 5e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 59 7e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 59 7e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 59 9e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 57 2e-08
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 57 3e-08
gi|62244004 modulator of estrogen induced transcription isoform ... 56 4e-08
gi|63176611 modulator of estrogen induced transcription isoform ... 56 4e-08
>gi|19557702 surfeit 6 [Homo sapiens]
Length = 361
Score = 698 bits (1802), Expect = 0.0
Identities = 361/361 (100%), Positives = 361/361 (100%)
Query: 1 MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREE 60
MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREE
Sbjct: 1 MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREE 60
Query: 61 KAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQR 120
KAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQR
Sbjct: 61 KAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQR 120
Query: 121 LHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEV 180
LHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEV
Sbjct: 121 LHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEV 180
Query: 181 VEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLL 240
VEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLL
Sbjct: 181 VEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLL 240
Query: 241 ERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRR 300
ERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRR
Sbjct: 241 ERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRR 300
Query: 301 AQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGL 360
AQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGL
Sbjct: 301 AQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGL 360
Query: 361 V 361
V
Sbjct: 361 V 361
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 75.1 bits (183), Expect = 9e-14
Identities = 72/309 (23%), Positives = 137/309 (44%), Gaps = 35/309 (11%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
++K + ++K ++REEK E + K ++ RR +EE W + +
Sbjct: 287 EEKMWRQEEKIQEREEKIQEQEEKIREQEEKM----RR----QEEMMWEKEEKMRRQEEM 338
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA 164
E E + L +++HE+ ++ R Q ++ E+ +R++QE +++ K
Sbjct: 339 MWEKEE--KIRELEEKMHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 395
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRV 224
+EK R+ EE + QE E E E E+ E E + Q K + Q
Sbjct: 396 EEKIREQEEMMQEQEEKMGEQEEKMWEQEE---------EMQEQEEKMRRQEEKIREQEK 446
Query: 225 KGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRD 284
K R + + + +E G+ EGK E EAKM+ + + KIR+
Sbjct: 447 KI-------REQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 285 DERLLQE----ALKRKEKRRAQRQRRW--EKRTAGVVEKMQQRQDRRRQNLRRKKAARAE 338
E+ ++E +++E + Q ++ W E++ EKMQ+++++ R+ + +K E
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR--QEEKMREQE 557
Query: 339 RRLLRARKK 347
RL + +K
Sbjct: 558 VRLRQQEEK 566
Score = 59.7 bits (143), Expect = 4e-09
Identities = 56/241 (23%), Positives = 100/241 (41%), Gaps = 15/241 (6%)
Query: 52 QKKFRKREEKAAEH-KAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPES 110
++K R+ EEK E K + EK R E +E+ A + + + E
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA----KMWRQEEKIREQEEK 398
Query: 111 VFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARK 170
+ + + Q EK+ E + +E E++ RR++E+ R++ K K +EK R+
Sbjct: 399 IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEK-KIREQEEKIRE 457
Query: 171 AEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTP 230
EE + QE EG E + ++ E E + Q K + Q K
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCE---------QEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 231 LTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
R ++++ + + +E + E K QE E KM+ + + V++R E +Q
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Query: 291 E 291
E
Sbjct: 569 E 569
Score = 52.0 bits (123), Expect = 8e-07
Identities = 70/319 (21%), Positives = 138/319 (43%), Gaps = 60/319 (18%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK--AKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPAD 102
K+K K Q+K + E + +E + K L K A + + EA D
Sbjct: 208 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA-----------D 256
Query: 103 GLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKEL 162
L E +SV A +L +++E + + ++ + QER+ K ++++E
Sbjct: 257 HLGKELQSVSA------KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE- 309
Query: 163 RAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQ 222
K R+ EE QE +++ K E K +R++E
Sbjct: 310 ----KIREQEEKMRRQE-----------------EMMWEKEE--------KMRRQEEMMW 340
Query: 223 RVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKI 282
+ + L + + Q R Q + R +E + +++ K QE EAKM + + KI
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQ-EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399
Query: 283 RDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQD--RRRQNLRRKKAARAERR 340
R+ E ++QE ++EK Q ++ WE+ E+MQ++++ RR++ R++ + +
Sbjct: 400 REQEEMMQE---QEEKMGEQEEKMWEQE-----EEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 341 LLRARKKGRILPQDLERAG 359
+ R++ ++ + E+ G
Sbjct: 452 EEKIREQEEMMQEQEEKMG 470
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 70.9 bits (172), Expect = 2e-12
Identities = 75/334 (22%), Positives = 138/334 (41%), Gaps = 44/334 (13%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ + A K + +T +++ ++ ++K R+RE+ E + + + + R E
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSE 207
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALE- 143
+E + TE E D R R + +E Q + S E
Sbjct: 208 RGRERERERETE---------TETERKRQTDRERDRQRKTEREREKQAERERASERETER 258
Query: 144 -KRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNK 202
K R R+++RDR + +R++ R ++ RK + TE E E RE
Sbjct: 259 DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER------- 311
Query: 203 VEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ 262
E + + + R+ +RQR T R+ + ER + RQ+ +D R + G+
Sbjct: 312 -ERNRKRERERERERERERQRE-------TERDREKERERKRKRQTEMDRERNRQTGREG 363
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEK-------RRAQRQRRWEKRTAGVV 315
+ AE + R+ ER Q A +R+E+ R+ +R+R+ EK G
Sbjct: 364 RRQ-----------AERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 316 EKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
E +QR+ + + R + ER + R++ R
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQKGRERDR 446
Score = 63.2 bits (152), Expect = 4e-10
Identities = 73/349 (20%), Positives = 143/349 (40%), Gaps = 20/349 (5%)
Query: 26 QQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEA 85
Q++ R G Q + A ++R + +++ R+RE++ E + E+ R+ +
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 86 AKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKR 145
+E D E + + RQ+ E+ E G+ + E+
Sbjct: 94 HRERQRDREKERERQTD---RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERE 150
Query: 146 RRRKQERDRKK-----------RKRKELRAKEKARKAEEATEAQEVVEATPEGACTE--- 191
R+R E++R++ R R++ R +EK R+ E Q E E +E
Sbjct: 151 RQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
Query: 192 PREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVK-GNLTPLTGRNYRQLLERLQARQSRL 250
RE + E + ++RK +R+R K + R + ER + R
Sbjct: 211 ERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDR 270
Query: 251 DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIR--DDERLLQEALKRKEKRRAQRQRRWE 308
D R Q E + Q + + T + E + R + ER + KR+ +R +R+R +
Sbjct: 271 DRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQ 330
Query: 309 KRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLER 357
+ T EK ++R+ +R+ + R++ + R R ++ R ++ +R
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR 379
Score = 53.5 bits (127), Expect = 3e-07
Identities = 58/259 (22%), Positives = 106/259 (40%), Gaps = 25/259 (9%)
Query: 109 ESVFALDVLRQRL-HEKIQEARGQGSA-KELSPAALEKRRRRKQERDRKKR--------K 158
E LD R+R ++ RG G A K+ E+ R++++ER R+KR K
Sbjct: 19 EVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK 78
Query: 159 RKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRK 218
R+ R K++ RK + E Q E E R+ + ++ K + R+
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTDRERDR--------QREKERNRQKERERE 130
Query: 219 EKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAE 278
+R+ +G G+ R+ + + R + Q + + + + + N + E
Sbjct: 131 TEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190
Query: 279 GVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAE 338
+ R+ E + E R ++R R E+ E ++RQ R ++ +RK E
Sbjct: 191 RERQREKEN-------KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERERE 243
Query: 339 RRLLRARKKGRILPQDLER 357
++ R R R +D ER
Sbjct: 244 KQAERERASERETERDKER 262
Score = 33.5 bits (75), Expect = 0.30
Identities = 46/236 (19%), Positives = 93/236 (39%), Gaps = 15/236 (6%)
Query: 26 QQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEA 85
++ R R K + ++++++T++ K E+ + + + E++ R +A
Sbjct: 308 ERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQA 367
Query: 86 AKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKR 145
+E + + E + D RQ+ E+ E G + EK+
Sbjct: 368 ERERERERERDRQSAREREERERDR----DRDRQKERERQTEKDRDGQRET------EKQ 417
Query: 146 RRRKQERDRKK-RKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVE 204
R R+++R+ ++ R+R R K+K R+ + + + + PP + V
Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVV 477
Query: 205 VSEDEPASKAQRRKEKRQRVKGNLTPLT-GRNYRQLLERLQAR---QSRLDELRGQ 256
S+ ++ R K + K T GR + R+ R + RL E RGQ
Sbjct: 478 QSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQ 533
Score = 28.9 bits (63), Expect = 7.5
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 7/83 (8%)
Query: 284 DDERLLQ-EALKRKEKRRAQRQ------RRWEKRTAGVVEKMQQRQDRRRQNLRRKKAAR 336
D ER Q E +R+EKR+ +R+ RR EK ++ ++RQ R + R+
Sbjct: 53 DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112
Query: 337 AERRLLRARKKGRILPQDLERAG 359
+R+ + R + + ++ ER G
Sbjct: 113 RDRQREKERNRQKERERETEREG 135
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 70.1 bits (170), Expect = 3e-12
Identities = 72/341 (21%), Positives = 151/341 (44%), Gaps = 42/341 (12%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
K++R++ ++++RK++E E + E+ R + +EE L
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE-------------L 1056
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAAL--EKRRRRKQERDRKKRKRKEL 162
E E + + +R E ++ R + ++ L E +RR+QER+R+ R+ +EL
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 163 RAKEKA--RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK 220
+ +E+ R+ E QE+ E + E L+ + E + + R +E+
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ-LLREEPEKRRRQELERQYREEEE 1175
Query: 221 RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWT--------- 271
Q+ + L RQ ER + L + + + ++ + +KW
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235
Query: 272 --NLLY----------KAEGVKIRD--DERLLQEAL-KRKEKRRAQRQRRWEKRTAGVVE 316
N +Y + E ++RD ++ LQ L +++E+ R Q +RRW++R E
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 317 KMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLER 357
+ Q ++ +++ RR + ++ E++LLR ++ + Q+ +R
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Score = 68.6 bits (166), Expect = 9e-12
Identities = 74/329 (22%), Positives = 147/329 (44%), Gaps = 30/329 (9%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
+QQ R R + E +K+ +K + RK EEK E + + E R+ E
Sbjct: 227 QQQRRERQDRVFQEEE----EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
++E L E + LR++ E+ +E + + ++ E+
Sbjct: 283 --RQELRRERQEEEQQQQRLRREQQ-------LRRKQEEERREQQEERREQQERREQQEE 333
Query: 145 RRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVE 204
RR ++ R++++R+ ++LR +++ + E+ ++ E + + R L +
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ----QLRREQQLRREQQL 389
Query: 205 VSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQ---DEGKA 261
E + + Q R+E++ R + L R +QL Q R+ + +E Q E +
Sbjct: 390 RREQQLRREQQLRREQQLRREQQL-----RREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 262 QELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQR 321
Q L+ + + K E R ++ ++ LKR ++ +R+ RW K E+ +++
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE--ERRERWLKLEE---EERREQ 499
Query: 322 QDRRRQNLRRKKAARAERRLLRARKKGRI 350
Q+RR Q LRR++ R E+RL R ++ R+
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERL 528
Score = 68.2 bits (165), Expect = 1e-11
Identities = 90/365 (24%), Positives = 162/365 (44%), Gaps = 45/365 (12%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
EQQ R + + + +++R++ Q + R++EE+ E + + E+ RR +
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLR-REQEEERREQQLRREQEEERREQQLRREQ 381
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
+ E L E Q+L + Q R Q +E ++
Sbjct: 382 QLRREQQLRREQQLRREQQLRRE-----------QQLRREQQLRREQQLRREQQLRREQE 430
Query: 145 RRRRKQERDRKKRKRKELRAKEKAR---KAEEATEA--QEVVEATPEGACTEPREPPGLI 199
R +Q+ ++++R+++ R +E+ R K EE TE QE + + E R L
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 200 FNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTG--------RNYRQLLERLQARQSRL- 250
+ E E + + Q R+E+ +R + L R+ +QL + R+ +L
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 251 ---DELRGQDEGKAQEL--EAKMKWTNLLYKAEGVKI----RDDERLLQEALKRKEKRRA 301
+E R + E + Q L E + + LL + E + R+ E L++ LKR+E R
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 302 QRQRRWE---KRTAGVVEKMQQ------RQDRRRQNLRRKKAARAERRLLRARKKGRILP 352
+++ R E KR E+ QQ +++RR+Q LRR++ R E+RL R ++ R L
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER-LE 669
Query: 353 QDLER 357
Q L+R
Sbjct: 670 QRLKR 674
Score = 65.9 bits (159), Expect = 6e-11
Identities = 67/322 (20%), Positives = 150/322 (46%), Gaps = 49/322 (15%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
+ ++++ Q++ +++EEK +++ ++ A ++ E + + W + G
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA 164
+ + A LR++ +++ Q + P EK +RR+Q R+R+K + + L
Sbjct: 782 ----QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK-ELQFLEE 836
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR------- 217
+E+ ++ E A + QE E GL + ++ S+ QRR
Sbjct: 837 EEQLQRRERAQQLQE--------------EEDGL-----QEDQERRRSQEQRRDQKWRWQ 877
Query: 218 -KEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYK 276
+E+R+R + L QL + Q Q +EL+ ++ K + E + + Y+
Sbjct: 878 LEEERKRRRHTLYAKPALQ-EQLRKEQQLLQEEEEELQREEREKRRRQEQERQ-----YR 931
Query: 277 AEGVKIRDDERLLQEALKRKEKRRAQRQRRW---------EKRTAGVVEKMQQRQDRRRQ 327
E +++E+LL+E +R+++RR +R+R++ E++ G + ++RQ+R ++
Sbjct: 932 EEEQLQQEEEQLLRE--EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 328 NLRRKKAARAERRLLRARKKGR 349
++ + E +LLR ++ R
Sbjct: 990 YREEEELQQEEEQLLREEREKR 1011
Score = 64.3 bits (155), Expect = 2e-10
Identities = 70/304 (23%), Positives = 137/304 (45%), Gaps = 13/304 (4%)
Query: 47 KRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLAT 106
K Q + ++ +++ E + + L E+ +R E +E A S + L
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS--EKQERLEQ 163
Query: 107 EPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKE 166
++ RQR + +E R + ++L + E ++R+ ELR K
Sbjct: 164 RDRQRRDEELWRQRQEWQEREER-RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 167 KARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKG 226
+ K ++ E Q+ V E RE L + ++ E+EP + + ++E+ Q K
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETV-LRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 227 NLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDE 286
L R RQ E+ Q R R +LR + E + +E + + + + + + + +E
Sbjct: 282 ERQEL--RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR------EQQERREQQEE 333
Query: 287 RLLQEALKRKEKRRAQRQRRWEKRTAGVVE-KMQQRQDRRRQNLRRKKAARAERRLLRAR 345
R Q+ + +E+RR Q+ RR ++ + + +Q ++RR Q LRR++ R E++L R +
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 346 KKGR 349
+ R
Sbjct: 394 QLRR 397
Score = 63.5 bits (153), Expect = 3e-10
Identities = 88/373 (23%), Positives = 156/373 (41%), Gaps = 77/373 (20%)
Query: 24 PEQQARTRAGKTQGSETAGPPKKKR----KKTQKKFRKREEKAAEHKAKSLGEKSPAASG 79
PE++ R + K++ E + +R ++ Q+ R+ EE+ E + K E+
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE----- 679
Query: 80 ARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSP 139
R E A+EE A + + ES D + +++ + ++ GQ
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLES--EADARQSKVYSRPRKQEGQ-------- 729
Query: 140 AALEKRRRRKQERDRKKRKRK-ELRAKEKARKAEEATEAQEVVEATPEGACTEPRE---- 194
RR+QE++ K+R+R+ EL+ +E+ R + E ++ + T + E E
Sbjct: 730 -------RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 195 -----PPGLIFNKVEVSED-----------EPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
PP + ++ + E K QRR+++R+R K L L Q
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQ 841
Query: 239 LLERLQARQSRLDELR-GQDEGKAQELEAKMKW-----------TNLLYKAEGV--KIRD 284
ER Q Q D L+ Q+ ++QE KW + LY + ++R
Sbjct: 842 RRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK 901
Query: 285 DERLLQE-----ALKRKEKRRAQRQRRWEKRTAGVVEKMQQ----------RQDRRRQNL 329
+++LLQE + +EKRR Q Q R + + ++ +Q RQ+R RQ
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 330 RRKKAARAERRLL 342
+ KK + E +LL
Sbjct: 962 KDKKLQQKEEQLL 974
Score = 59.7 bits (143), Expect = 4e-09
Identities = 74/331 (22%), Positives = 148/331 (44%), Gaps = 34/331 (10%)
Query: 47 KRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPA----D 102
+R++ +KFR++E ++ E + K L E+ R+ + +EE G D
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 103 GLATEPESVFA----LDVLRQRLHEKI----QEARGQGSAKELSPAALEKRRRR-----K 149
E E + + RQ K Q+ R Q ++ + RR+ +
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 150 QERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDE 209
QERDRK R+ ++L + + ++ ++ +E P+ E + ++ E++
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
Query: 210 PASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMK 269
+ + ++ +RQ R +R+ ++L+ ++ L+ + + + QELE K +
Sbjct: 1675 LLQEGEEQQLRRQE--------RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR 1726
Query: 270 WTNLL-YKAEGVKIRDDER---LLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
L + E ++R ER +L+E R E R ++Q R ++R E+ Q RQ+R
Sbjct: 1727 EEEQLRQETEQEQLRRQERYRKILEEEQLRPE--REEQQLRRQERDRKFREEEQLRQERE 1784
Query: 326 RQNLRRKKAARA---ERRLLRARKKGRILPQ 353
Q LR +++ R E +L + R++ ++ PQ
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Score = 58.5 bits (140), Expect = 9e-09
Identities = 69/341 (20%), Positives = 150/341 (43%), Gaps = 48/341 (14%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAE-----------HKAKSLGEK 73
+++ + RA + Q E P+++ K+ +++ R+ EK + +A+ L E+
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 74 SPAASG---ARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARG 130
RR + + + W + +++A L+++L ++ Q
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLE----EERKRRRHTLYAKPALQEQLRKEQQLL-- 906
Query: 131 QGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACT 190
Q +EL EKRRR++QER ++ ++ + ++ R+ E QE
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE----------- 955
Query: 191 EPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRL 250
RE K++ E++ + ++ +++R K YR+ E Q + L
Sbjct: 956 --RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK---------KYREEEELQQEEEQLL 1004
Query: 251 DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDD--ERLLQEALKRKEKRRAQRQRRWE 308
E R ++ + QE E + + + L + E +R++ +R LQE + ++ R + ++ E
Sbjct: 1005 REER--EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEE 1060
Query: 309 KRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
++ G + ++RQ+ RQ + ++ + E +LLR + R
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Score = 58.2 bits (139), Expect = 1e-08
Identities = 56/218 (25%), Positives = 104/218 (47%), Gaps = 20/218 (9%)
Query: 143 EKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNK 202
E+RR +++ R+++ R+ +E R +++ ++ EE Q+ + + + E E + +
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ-LRREQEERREQLLKR 552
Query: 203 VEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLL-----ERLQARQSRLD-ELRGQ 256
E E + QR K +++ + L +Q L ERL+ R R + E Q
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 257 DEGKAQEL---EAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAG 313
+E + Q L E + + L K+E +ER Q+ + +++RR QR +R E+
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLRREQQERREQRLKREEEE--- 665
Query: 314 VVEKMQQRQDRRRQNLRR-KKAARAERRLLRARKKGRI 350
E+++QR R + RR ++ A E+ R R K RI
Sbjct: 666 --ERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701
Score = 57.0 bits (136), Expect = 3e-08
Identities = 59/256 (23%), Positives = 119/256 (46%), Gaps = 28/256 (10%)
Query: 119 QRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQ 178
QR +K QE + + E +++ R ++RDR++R + R +++ ++ EE +
Sbjct: 135 QRRRQKRQEQERELAEGEEQ----SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE 190
Query: 179 EVVEATPEGACTE--PREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNY 236
E +++ +G TE P E +E+ K Q+R+E++ RV + +
Sbjct: 191 EQLQSC-KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV---FQEEEEKEW 246
Query: 237 RQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK 296
R+ L+ + +L E Q + + QE E +++ L + E + R +E Q+ L+R+
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR---KLERQELRRERQEEEQQQQRLRRE 303
Query: 297 ---------------EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRL 341
E+RR Q++RR ++ + +++++RR Q LRR++ +
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Query: 342 LRARKKGRILPQDLER 357
LR ++ Q L R
Sbjct: 364 LRREQEEERREQQLRR 379
Score = 56.2 bits (134), Expect = 4e-08
Identities = 75/351 (21%), Positives = 149/351 (42%), Gaps = 60/351 (17%)
Query: 44 PKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPAD- 102
P+K+R++ ++ + EE+ + + + L E+ R + +EE D
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 103 ------GLATEPESVFALD----VLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQER 152
EPE A+ + R +E+ ++ S L+ +QER
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 153 DRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPAS 212
DR++ +R+ + +++ EE E +E EA + S++E
Sbjct: 1278 DREQERRR-WQQRDRHFPEEEQLEREEQKEAK----------------RRDRKSQEEKQL 1320
Query: 213 KAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQS------------RLDELRGQDEGK 260
+ R+EKR+R + T R +R+ + LQ R+ R +ELR Q++G+
Sbjct: 1321 LREEREEKRRRQE------TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374
Query: 261 -----AQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEK-RTAGV 314
Q L + + L + + ++ ++ E+ L++ RK + Q+ R E+ R
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 315 VEKMQQRQDRRRQNLRRKKAARAER--------RLLRARKKGRILPQDLER 357
E+ +RQ+R R+ L ++ R ER +LL+ R++ ++ Q+ +R
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/266 (23%), Positives = 116/266 (43%), Gaps = 47/266 (17%)
Query: 126 QEARGQGSAKELSPAALEKRRRRKQERDR-------KKRKRKELRAKEKARKAEEATEAQ 178
+ AR G L E+ +RR + RDR ++R++K + + + EE +E Q
Sbjct: 99 KRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ 158
Query: 179 EVVEATPEGACTEP---------------REPPGLIFNKVEVSEDEPASKAQRRKEKRQ- 222
E +E E E L K +E+ P + RR+E +
Sbjct: 159 ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 223 RVKGNLTPLTGRNYRQ-----------LLERLQARQSRLDELRGQDEGKAQELEAKMKWT 271
R KG R RQ +R + ++L+ ++ + +EL+ + +
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 272 NLLYKAEGVKIRDDERLLQEALKR--------KEKRRAQRQRRWEKRTAGVVEKMQQRQD 323
L + E + R +E Q+ L+R +E+RR Q++ R E++ E+ +Q+++
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ-----ERREQQEE 333
Query: 324 RRRQNLRRKKAARAERRLLRARKKGR 349
RR Q LRR++ R E++L R +++ R
Sbjct: 334 RREQQLRREQEERREQQLRREQEEER 359
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/329 (20%), Positives = 137/329 (41%), Gaps = 40/329 (12%)
Query: 21 HSAPEQQARTRAGKT---QGSETAGPPKKK-RKKTQKKFRKREEKAAEHKAKSLGEKSPA 76
H EQQ R R + Q + P +++ ++ QK+ ++R+ K+ E K E+
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 77 ASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKI--QEARGQGSA 134
+EE P + RQ K +E R Q
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQP---------------LRRQERDRKFREEELRHQEQG 1373
Query: 135 KELSPAALEKRRRRKQERDRK-KRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR 193
++ E++R R+QER+RK ++ ++LR +E+ ++ + + + E R
Sbjct: 1374 RKFLE---EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 194 EPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDEL 253
+ E+E + Q R+ K + L R +R+ + LQ R+ + +L
Sbjct: 1431 K----------FREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ--QL 1478
Query: 254 RGQDEGKA---QELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKR 310
Q+ + +E + + + + ++ + ++ ++ ER E ++ +++ QR+ E++
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ 1538
Query: 311 TAGVVEKMQQRQDRRRQNLRRKKAARAER 339
E+ QQR+ R + R ++ R ER
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Score = 46.6 bits (109), Expect = 3e-05
Identities = 68/318 (21%), Positives = 131/318 (41%), Gaps = 36/318 (11%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARR-P 83
EQQ R + G+ Q R++ +KFR+ E+ E + + L + P
Sbjct: 1601 EQQLRRQEGQQQ----------LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP 1650
Query: 84 EAAKEEAAWASSSAGNPADGLATEPESVFA----LDVLRQRLHEKIQEARGQGSAKELSP 139
+ ++E + D E E + + RQ K +E Q +E
Sbjct: 1651 QLRRQER---EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 140 AAL-EKRRRRKQERDRKKRKRKELRAK---EKARKAEEATEAQEVVEATPEGACTEPREP 195
L E+++ R+QE +RK R+ ++LR + E+ R+ E + E + PE RE
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE------REE 1761
Query: 196 PGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRG 255
L + + E Q R+E Q+++ + R QL + + +Q R + G
Sbjct: 1762 QQLRRQERDRKFREEEQLRQEREE--QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 256 QDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKR------RAQRQRRWEK 309
+ + ++L+ + + L + + +++ QE +R+E+ + +RQ R K
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Query: 310 RTAGVVEKMQQRQDRRRQ 327
+ + Q+ + R RQ
Sbjct: 1880 LREEHIRRQQKEEQRHRQ 1897
Score = 44.3 bits (103), Expect = 2e-04
Identities = 38/148 (25%), Positives = 71/148 (47%), Gaps = 8/148 (5%)
Query: 218 KEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQ-DEGKAQELEAKM-KWTNLLY 275
+EKR R G + L R + R + R +L+E GQ K QE E ++ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 276 KAEGVKIRDDERLLQEALKR------KEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNL 329
K E ++ RD +R +E ++ +E+RRA+ ++ + E + Q RRR+ L
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 330 RRKKAARAERRLLRARKKGRILPQDLER 357
++ R E++ R ++ R+ ++ E+
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEK 244
Score = 37.0 bits (84), Expect = 0.027
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 19/128 (14%)
Query: 117 LRQRLHE---KIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEE 173
LRQ E + Q+ G+ +E E+ +R +QERDR+ R ++ +EK+R+ E+
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQ 1862
Query: 174 ATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTG 233
+E + E E E + Q+++E+R R G + G
Sbjct: 1863 ELWQEEEQKRRQER----------------ERKLREEHIRRQQKEEQRHRQVGEIKSQEG 1906
Query: 234 RNYRQLLE 241
+ + +LLE
Sbjct: 1907 KGHGRLLE 1914
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 67.0 bits (162), Expect = 2e-11
Identities = 73/334 (21%), Positives = 145/334 (43%), Gaps = 42/334 (12%)
Query: 44 PKKKRKKTQKKFRKRE-EKAAEHKAKSLGEKS----PAASGARRPEAAKEEAAWASSSAG 98
PKK + K QK +K + + E +K + E+S SG E + +
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKN 206
Query: 99 NPADGLAT---EPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
P + + + ++ F + + Q+ EK + R + ++ K R+ K++ + +
Sbjct: 207 KPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKA------KLRKLKEKEELE 260
Query: 156 KRKRKELRAKEKARKAEEATEAQEV-VEATPEGACTEPREPPGLIFNKVE---VSEDEPA 211
K+ + + KE RK EE T +V V+ A E E P + E +D+
Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKK 320
Query: 212 SKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWT 271
K ++ ++++++ KG + T + ++ L +L+ + R + + +ELEAK K
Sbjct: 321 KKGEKEEKEKEKKKGP-SKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK-- 377
Query: 272 NLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRR 331
++ERL QE +RK+++ +R+ R +K + + ++ + R L+
Sbjct: 378 ------------EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL 425
Query: 332 KKAARAE---------RRLLRARKKGRILPQDLE 356
+A E +R + KK + +PQ LE
Sbjct: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Score = 46.2 bits (108), Expect = 5e-05
Identities = 61/269 (22%), Positives = 118/269 (43%), Gaps = 40/269 (14%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
+KK +K +++ +KR+E+ A K + L EK +G + KE
Sbjct: 230 QKKAEKKERERKKRDEEKA--KLRKLKEKEELETGKKDQSKQKES--------------- 272
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRK-RKELR 163
+ F + ++ ++ E AA + K+++D+KK+K KE +
Sbjct: 273 ----QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
Query: 164 AKEKARKAEEAT--EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKR 221
KEK + +AT QE + E + RE I ++E E + + + +EKR
Sbjct: 329 EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERI-KRLEELEAKRKEEERLEQEKR 387
Query: 222 QRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVK 281
+R K + ++ ERL+ L + Q E +A+ EA +K L +A+GV+
Sbjct: 388 ERKK--------QKEKERKERLKKEGKLLT--KSQREARARA-EATLK----LLQAQGVE 432
Query: 282 IRDDERLLQEALKRKEKRRAQRQRRWEKR 310
+ + L ++ ++K+R + ++ E +
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKKIPQQLESK 461
Score = 41.2 bits (95), Expect = 0.001
Identities = 66/325 (20%), Positives = 124/325 (38%), Gaps = 43/325 (13%)
Query: 23 APEQQARTRAGKTQGSETAGPPK-KKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
A E++A T +E K KK+KK +K+ +++E+K KA + A
Sbjct: 294 ASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKE 353
Query: 82 RPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAA 141
E K E + E E + R++ EK ++ R + K L+ +
Sbjct: 354 EEERQKREEEERIKRL-EELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
Query: 142 LEKRRRR----------------KQERDRKK-----RKRKELRAKEKARKAEEATEAQEV 180
E R R K +K+ +KRK++ + ++++ E+ E
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
Query: 181 VEATPEGACTEPREPPGLIFNKVEVSEDEPAS--KAQRRKEKRQRVKGNLTPLTGRNYRQ 238
VE +G + PP + + E +ED +A E+ ++V+GN + + +
Sbjct: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPE 532
Query: 239 LLERLQARQ------SRLDELRGQDEGKAQELEAKM------------KWTNLLYKAEGV 280
E + + +E G+ EG + E + K + ++
Sbjct: 533 EEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592
Query: 281 KIRDDERLLQEALKRKEKRRAQRQR 305
DD+R +E K KRR +++R
Sbjct: 593 YDSDDDRTKEERAYDKAKRRIEKRR 617
Score = 35.8 bits (81), Expect = 0.061
Identities = 48/219 (21%), Positives = 96/219 (43%), Gaps = 22/219 (10%)
Query: 25 EQQARTRAGKTQGS-ETAGPPKKKRKKTQKKFRKREEK--------------AAEHKAKS 69
E++A+ R K + ET + K+K++Q+KF EE+ A+E KA++
Sbjct: 245 EEKAKLRKLKEKEELETGKKDQSKQKESQRKF---EEETVKSKVTVDTGVIPASEEKAET 301
Query: 70 LGEKSPAASGARRPEAAKEEAAWASSSAGNPADG--LATEPESVFALDVLR-QRLHEKIQ 126
G ++ + K++ G AT AL L+ + +K +
Sbjct: 302 PTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKRE 361
Query: 127 EARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPE 186
E +EL E+ R +++R+RKK+K KE + + K ++ + T++Q A E
Sbjct: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLK-KEGKLLTKSQREARARAE 420
Query: 187 GACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVK 225
+ + +K + + P + ++RK+ Q+++
Sbjct: 421 ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE 459
Score = 32.3 bits (72), Expect = 0.68
Identities = 44/258 (17%), Positives = 109/258 (42%), Gaps = 35/258 (13%)
Query: 127 EARGQGSAKELSP---AALEKRRRRKQERDRKK--RKRKELRAKEKARKAEEATEAQEVV 181
E G G+AKE P +K+ ++KQ+ D ++ +EL + + KA+ T A +
Sbjct: 25 EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT 84
Query: 182 EATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGR----NYR 237
E E ++ ++ G K +++ + + ++ K + +G ++
Sbjct: 85 ENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFN 144
Query: 238 QLLERLQARQSRLDEL---RGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALK 294
+L ++ + + + ++ +DE +++++ + + + G + + LQ
Sbjct: 145 KLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSR-----INSSGESGDESDEFLQ---S 196
Query: 295 RKEKRRAQRQRRWEKRTAG------------VVEKMQQRQDRRRQNLRRKKA---ARAER 339
RK +++ Q+ + +G V +K ++++R R+ +KA E+
Sbjct: 197 RKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEK 256
Query: 340 RLLRARKKGRILPQDLER 357
L KK + ++ +R
Sbjct: 257 EELETGKKDQSKQKESQR 274
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 63.5 bits (153), Expect = 3e-10
Identities = 56/212 (26%), Positives = 96/212 (45%), Gaps = 31/212 (14%)
Query: 139 PAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGL 198
P + R+K+ R+R+KRKR+ +EK RK E + ++ + G E +
Sbjct: 28 PCTQRESERKKERREREKRKRE----REKERKRERGKKEKKKRKKRERGKERERKR---- 79
Query: 199 IFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDE 258
E E K +R KE+R+R K ++ + +Q E + + E
Sbjct: 80 -------KEREKQRKERREKERRKRKKEK-------------KKRERKQRGRRERKKKKE 119
Query: 259 GKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKR-RAQRQRRWEKRTAGVVEK 317
K +E E K + K K R + + +E KR+ KR + +++ R +KR E+
Sbjct: 120 RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKER 179
Query: 318 MQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
++R+ R++ RKK + ERR + RKK R
Sbjct: 180 KKERE--RKERRERKKERKKERRKKKERKKDR 209
Score = 50.4 bits (119), Expect = 2e-06
Identities = 48/223 (21%), Positives = 94/223 (42%), Gaps = 66/223 (29%)
Query: 118 RQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEA 177
R + +K ++ R +G +E EK+R+ ++E++R+KRK+++ + + K R E +
Sbjct: 58 RGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKK- 116
Query: 178 QEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYR 237
K E E E +K +R +++++R K
Sbjct: 117 ------------------------KKERKERERENKQRRERKRKKRRK------------ 140
Query: 238 QLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKE 297
++ R + R ++ GK + K K K E K R+ R K ++
Sbjct: 141 --------KKRRKERKREKERGKRERKRKKRK------KEEREKKRERNR------KERK 180
Query: 298 KRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERR 340
K R +++RR E+ ++R+ RR+ RKK + +R+
Sbjct: 181 KERERKERR---------ERKKERKKERRKKKERKKDRKTDRQ 214
Score = 47.4 bits (111), Expect = 2e-05
Identities = 52/204 (25%), Positives = 83/204 (40%), Gaps = 28/204 (13%)
Query: 19 CSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAAS 78
CSH + R K + E ++KRK+ ++K RKRE E K + E+
Sbjct: 22 CSHISKPCTQRESERKKERRE-----REKRKREREKERKRERGKKEKKKRKKRER----- 71
Query: 79 GARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELS 138
G R KE E E R+R EK + R Q +E
Sbjct: 72 GKERERKRKEREKQRKE---------RREKER-------RKRKKEKKKRERKQRGRRERK 115
Query: 139 PAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGL 198
E++ R ++ + R++RKRK+ R K+K RK + + + E + E RE
Sbjct: 116 KKK-ERKERERENKQRRERKRKK-RRKKKRRKERKREKERGKRERKRKKRKKEEREKKRE 173
Query: 199 IFNKVEVSEDEPASKAQRRKEKRQ 222
K E E + +R+KE+++
Sbjct: 174 RNRKERKKERERKERRERKKERKK 197
Score = 45.8 bits (107), Expect = 6e-05
Identities = 36/159 (22%), Positives = 70/159 (44%), Gaps = 9/159 (5%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
+++ + R + +G E ++KRK+ +K+ ++R EK + K ++ G R +
Sbjct: 60 KKEKKKRKKRERGKER----ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERK 115
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
KE + + + R++ K + R + +E
Sbjct: 116 KKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN 175
Query: 145 RRRRKQERDRK-----KRKRKELRAKEKARKAEEATEAQ 178
R+ RK+ER+RK K++RK+ R K+K RK + T+ Q
Sbjct: 176 RKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214
Score = 45.4 bits (106), Expect = 8e-05
Identities = 41/149 (27%), Positives = 74/149 (49%), Gaps = 15/149 (10%)
Query: 213 KAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTN 272
+++R+KE+R+R K R + ER + R + + R + E + +E E K K
Sbjct: 33 ESERKKERREREK--------RKREREKERKRERGKKEKKKRKKRE-RGKERERKRKERE 83
Query: 273 LLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDR----RRQN 328
K K R + +E KR+ K+R +R+R+ +K + +QR++R RR+
Sbjct: 84 KQRKERREKERRKRK--KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKK 141
Query: 329 LRRKKAARAERRLLRARKKGRILPQDLER 357
RRK+ R + R R RK+ + ++ E+
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREK 170
Score = 45.1 bits (105), Expect = 1e-04
Identities = 34/154 (22%), Positives = 67/154 (43%), Gaps = 28/154 (18%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ R + K + + G ++K+KK +K+ + ++ E K K +K R E
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
K E ++R E+ ++ R + + ++
Sbjct: 153 RGKRERK-------------------------RKKRKKEEREKKRERNRKERKKERERKE 187
Query: 145 RRRRKQERDRKKRKRKELRAKEKARKAEEATEAQ 178
RR RK+ER +++RK+KE ++K RK + T++Q
Sbjct: 188 RRERKKERKKERRKKKE---RKKDRKTDRQTDSQ 218
Score = 42.0 bits (97), Expect = 9e-04
Identities = 35/166 (21%), Positives = 69/166 (41%), Gaps = 5/166 (3%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK---AAEHKAK 68
+S KK ++ R + K + + +KKR++ +++ RKR+E+ E + K
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 69 SLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEA 128
++ R + + E + ++R K ++
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 129 RG--QGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAE 172
RG + K+ EK+R R ++ +K+R+RKE R ++K RK E
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKE 198
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 63.2 bits (152), Expect = 4e-10
Identities = 49/230 (21%), Positives = 112/230 (48%), Gaps = 31/230 (13%)
Query: 120 RLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQE 179
R E+ E R +G + S E+R R K++R+R+K +++E KEK K E E +E
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK--KGERKKEERE 96
Query: 180 VVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQL 239
+ E E++ + ++RK+K ++ +G T G+ +
Sbjct: 97 RKKRRRE-------------------KENKEGEEKEKRKKKEKKERGR-TSKEGKERERK 136
Query: 240 LERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKR 299
ER + + + + + E + + E K + + + V +++ER +E +RK++
Sbjct: 137 EERKREERKERERKKEEREKERERKERKKR------ERKQVGEKEEERKEKERKERKKRE 190
Query: 300 RAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
R +++R+ E+ E+ +++++R+++ R+K+ + + R +++G+
Sbjct: 191 RNRKERKKERERK---ERRERKKERKKKEERKKERQKDRQTNWREKERGK 237
Score = 57.8 bits (138), Expect = 2e-08
Identities = 63/255 (24%), Positives = 103/255 (40%), Gaps = 38/255 (14%)
Query: 19 CSH-----SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEK 73
CSH + P Q+ R + + ET KK+R+ +KK R+ EK + K
Sbjct: 22 CSHISKPCTQPGWQSEIRERERE-IETRKEGKKERESERKKERREREKRKREREKE---- 76
Query: 74 SPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGS 133
R+ E K+E E E+ + +++ EK + R
Sbjct: 77 -------RKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKE 129
Query: 134 AKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR 193
KE E++ RK+E +++ ++KE R KE+ RK + E ++V E E E +
Sbjct: 130 GKER-----ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERK 184
Query: 194 EPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQ-SRLDE 252
E K + K + RKE+R+R K ++ ER + RQ R
Sbjct: 185 E------RKKRERNRKERKKERERKERRERKK---------ERKKKEERKKERQKDRQTN 229
Query: 253 LRGQDEGKAQELEAK 267
R ++ GK + E K
Sbjct: 230 WREKERGKRERKERK 244
Score = 40.0 bits (92), Expect = 0.003
Identities = 32/155 (20%), Positives = 70/155 (45%), Gaps = 28/155 (18%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ R R K +G E ++KR++ +++ RK+EE+ E + K ++ G + E
Sbjct: 119 EKKERGRTSK-EGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEE 177
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
++E R+R ++ ++ R + +E +K
Sbjct: 178 RKEKERKERKK----------------------RERNRKERKKERERKERRER-----KK 210
Query: 145 RRRRKQERDRKKRKRKELRAKEKARKAEEATEAQE 179
R++K+ER ++++K ++ +EK R E E ++
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 38.9 bits (89), Expect = 0.007
Identities = 29/139 (20%), Positives = 62/139 (44%)
Query: 209 EPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKM 268
+P ++ + E R+R + T G+ R+ + + R+ + + E K + + +
Sbjct: 27 KPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 269 KWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQN 328
K + E K R ++ + K K K++ +++R + E+ ++R+ R+
Sbjct: 87 KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146
Query: 329 LRRKKAARAERRLLRARKK 347
RKK R + R + RKK
Sbjct: 147 RERKKEEREKERERKERKK 165
Score = 36.6 bits (83), Expect = 0.036
Identities = 40/186 (21%), Positives = 85/186 (45%), Gaps = 17/186 (9%)
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVS---EDEPASKAQRRKEKRQRVKGNLTPL 231
TE Q V + CT+P + + E+ E + +++R+KE+R+R K
Sbjct: 15 TELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREK------ 68
Query: 232 TGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ ER + R+ + + E K +E E K + K EG + ++ ++
Sbjct: 69 ------RKREREKERKRERGKKEKKGERKKEERERKKRRREKENK-EGEEKEKRKKKEKK 121
Query: 292 ALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRIL 351
R K +R+R+ E++ E+ +++++R ++ RK+ + ER+ + +++ R
Sbjct: 122 ERGRTSKEGKERERKEERKREERKERERKKEEREKER-ERKERKKRERKQVGEKEEERKE 180
Query: 352 PQDLER 357
+ ER
Sbjct: 181 KERKER 186
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 63.2 bits (152), Expect = 4e-10
Identities = 74/312 (23%), Positives = 134/312 (42%), Gaps = 30/312 (9%)
Query: 52 QKKFRKREEKAAEH-KAKSLGEKSPAASGARRPEAAKEEAA--WASSSAGNPADGLATEP 108
++K R+ EEK E K + EK R E +E+ A W + E
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 109 ESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKA 168
E + EKI+E + +E+ E++ R ++E R+K K E +EK
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQEEIWRQKEKIHE--QEEKI 552
Query: 169 RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNL 228
RK EE QE E E E KV E++ + ++ +E+ +++
Sbjct: 553 RKQEEKMWRQEEKMHDQEEKIREQEE-------KVWRQEEKIREQEEKIREQEEKI---- 601
Query: 229 TPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERL 288
R ++ + + + +E + E K QE E KM+ + + KIR+ E
Sbjct: 602 -----REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK 656
Query: 289 LQEALKRKEKRRAQRQRRW--EKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARK 346
++E ++E + Q ++ W E++ EKMQ+++++ R+ + +K E RL + +
Sbjct: 657 IRE---QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR--QEEKMWEQEVRLRQQEE 711
Query: 347 KGRILPQDLERA 358
K + + LE A
Sbjct: 712 KMQEHQEHLEAA 723
Score = 51.6 bits (122), Expect = 1e-06
Identities = 70/359 (19%), Positives = 160/359 (44%), Gaps = 43/359 (11%)
Query: 5 LAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAE 64
L+ + Y ++ + + Q + + +++ SE K+ ++K ++ ++ +
Sbjct: 266 LSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 325
Query: 65 HKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEK 124
+A LG++ + S A+ +E W + + E ++ + Q EK
Sbjct: 326 AEADHLGKELQSVS-AKLQAQVEENELWNRLNQ--------QQEEKMWRQEEKIQEWEEK 376
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQ----ERDRKKRKRKEL--RAKEKARKAEEATEAQ 178
IQE + +E E++ RR++ E++ K R+++E+ +EK R+ EE +
Sbjct: 377 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 436
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQ---RRKEKRQRVKGNLTPLTGRN 235
E + RE + + ++ E E + + R +EKRQ + +
Sbjct: 437 E----------EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW-RQEEK 485
Query: 236 YRQLLERLQARQSRL--DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEAL 293
R+ E+++ ++ ++ E + ++ K +E E + + + + E KIR+ E + ++
Sbjct: 486 IREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE--KIREQEEIWRQKE 543
Query: 294 K---RKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
K ++EK R Q ++ W + EKM ++++ R+ + +K R E ++ +K R
Sbjct: 544 KIHEQEEKIRKQEEKMWRQE-----EKMHDQEEKIRE--QEEKVWRQEEKIREQEEKIR 595
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 62.4 bits (150), Expect = 6e-10
Identities = 79/351 (22%), Positives = 146/351 (41%), Gaps = 17/351 (4%)
Query: 17 KICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPA 76
+I H E++ + RA +E A ++R++ + + +++K A+ +A+ E+ A
Sbjct: 250 EISHHEKMEEEDKERAE----AERARLEAEERERIKAE---QDKKIADERARIEAEEKAA 302
Query: 77 ASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKE 136
A R EA + E E E A + R + EK Q +E
Sbjct: 303 AQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEE 362
Query: 137 LSPAALEKRRRRKQERDRKK--RKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR- 193
AA E++R R +E ++ K +++ + +EK +E E VE EG +
Sbjct: 363 EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422
Query: 194 -EPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTP--LTGRNYRQLLERLQARQSRL 250
+ L ++ +E +K Q ++EK Q K + ++ E + +S +
Sbjct: 423 AQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFM 482
Query: 251 DELRGQDEGKAQELEA---KMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRW 307
D +G E K+Q E K+K T + G + D + + A + + +R + RR
Sbjct: 483 DRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR 542
Query: 308 EKRTAGV-VEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLER 357
T EK++Q+Q L K R ERR + ++ R ++ +R
Sbjct: 543 RGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADR 593
Score = 56.6 bits (135), Expect = 3e-08
Identities = 68/345 (19%), Positives = 149/345 (43%), Gaps = 37/345 (10%)
Query: 34 KTQGSETAGPPKKKRKKTQKKFRKREE--KAAEHKAKSLGEKSPAASGARRPEAAKEEAA 91
+ + E A +++R++ +++ R REE +AAE + + E+ AA +R + ++ AA
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
Query: 92 WASSSAGNPADGLATEPESVFALD-----VLRQRLHEKIQEARGQGSAKELSPAALEKRR 146
A E + A + V Q+ +++++E + ++ +E++
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413
Query: 147 RRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVS 206
K ++K ++ K A K + E+ T+ Q E E T F K E+
Sbjct: 414 EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPT---------FKKEEIK 464
Query: 207 EDEPASKAQRRKEKRQRVKG------NLTPLTGRNYRQLLERLQARQSRLDELRGQ---- 256
++ K ++ KE ++ VK T + +N + +L+ ++ G+
Sbjct: 465 DE----KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVD 520
Query: 257 --DEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGV 314
+ A ++EA + L + + + E+L Q+ + + +++R E+R
Sbjct: 521 TKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLE 580
Query: 315 VEKMQQRQDRRRQNLRRKKAAR-----AERRLLRARKKGRILPQD 354
E+ +++Q+ + LR ++ R ERR A +K + +P+D
Sbjct: 581 EEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 55.5 bits (132), Expect = 7e-08
Identities = 67/334 (20%), Positives = 147/334 (44%), Gaps = 44/334 (13%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKT---QKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
E++ R R + + +E K++ K+ +++ ++ E++AAE + + E+ AA +
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371
Query: 82 RPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEA---RGQGSAKELS 138
R A +EE A N L + ++ + +++ +KI+ + +L
Sbjct: 372 RARAEEEEKAKVEEQKRNKQ--LEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQ 429
Query: 139 PAALEKR----------RRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGA 188
A L+K+ +R K + D+ K++E++ EK +K +E E + +G
Sbjct: 430 TAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK-DEKIKKDKEPKEEVKSFMDRKKGF 488
Query: 189 CTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQS 248
+ + +K++ +E+ + R + +G G+ +L R
Sbjct: 489 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRR------ 542
Query: 249 RLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWE 308
RG+ E + E + K K + E +K + +ER ++ L+ +E+RR Q +
Sbjct: 543 -----RGETESEEFE-KLKQKQQEAALELEELKKKREER--RKVLEEEEQRRKQEE---- 590
Query: 309 KRTAGVVEKMQQRQDRRR--QNLRRKKAARAERR 340
K+++ +++RR + + R++A AE+R
Sbjct: 591 -----ADRKLREEEEKRRLKEEIERRRAEAAEKR 619
Score = 52.8 bits (125), Expect = 5e-07
Identities = 75/356 (21%), Positives = 151/356 (42%), Gaps = 56/356 (15%)
Query: 21 HSAPEQQARTRAGKTQ--GSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAAS 78
+S P+++A+T TQ G + A ++ ++ +++ ++ +E K E P +
Sbjct: 72 NSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK-----EFDPTIT 126
Query: 79 GARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELS 138
A ++ + A+ TE E RQ +E I+E E
Sbjct: 127 DASLSLPSRR-------MQNDTAENETTEKEEK---SESRQERYE-IEET-------ETV 168
Query: 139 PAALEKRRRRKQERDRKKRKRKELRAKEKARKA------------EEATEAQE--VVEAT 184
+ +K R E ++K+ K KE +EK ++ E+ TE+QE VV +
Sbjct: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSL 228
Query: 185 PEGACT--EPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLER 242
G + EP++ + E DE + + +E ++R + L ER
Sbjct: 229 KNGQISSEEPKQE-----EEREQGSDEISHHEKMEEEDKERAEAERARLEAEER----ER 279
Query: 243 LQARQSR--LDE---LRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKE 297
++A Q + DE + +++ AQE E + + E + ++ + ++E KR
Sbjct: 280 IKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339
Query: 298 KRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQ 353
+ R QR + EKR A +++++ + R + +R +A E+ + +K+ + L +
Sbjct: 340 EER-QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEE 394
Score = 52.0 bits (123), Expect = 8e-07
Identities = 86/361 (23%), Positives = 157/361 (43%), Gaps = 60/361 (16%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRK------KTQKKFRKREEKAAEHKAK--SLGEKSPA 76
E+++ +R + + ET K +K + KK K +E+ E K K S+GE
Sbjct: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
Query: 77 ASGARRPEAAKEEAAWASSSAGN-PADGLATEPESVFALDVLRQRLHEKIQEARGQGSAK 135
+ ++EE S G ++ E E D + HEK++E + +
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH--HEKMEEEDKERAEA 267
Query: 136 ELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-KAEEATEAQEVVEATPEGACTEPRE 194
E + E+R R K E+D+K A E+AR +AEE AQE E E RE
Sbjct: 268 ERARLEAEERERIKAEQDKKI-------ADERARIEAEEKAAAQE-----RERREAEERE 315
Query: 195 PPGLIFNKVEVSEDEPASKAQRRK-------EKRQRVK-------GNLTPLTGRNYRQLL 240
++ E A + QR K E+RQR+K + R
Sbjct: 316 -------RMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 368
Query: 241 ERLQARQSRLDELRGQDEGKAQELEAK---MKWTNLLYKAEGVKIRDDERLLQEALKRKE 297
ER +AR ++ + +++ + ++LE K M+ T + K E V+ + + + + E +++
Sbjct: 369 ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI--KGEKVEQKIEGKWVNEKKAQED 426
Query: 298 K-RRAQRQRRWEKRTAGVV---EKMQQ------RQDRRRQNLRRKKAARAERRLLRARKK 347
K + A +++ E++ V EK+Q+ +++ + + +++ K + E + RKK
Sbjct: 427 KLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKK 486
Query: 348 G 348
G
Sbjct: 487 G 487
Score = 46.2 bits (108), Expect = 5e-05
Identities = 62/295 (21%), Positives = 117/295 (39%), Gaps = 29/295 (9%)
Query: 16 KKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQ-------------KKFRKREEKA 62
K + A E + +T K QG E + KR+K Q +K +K +E
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK 475
Query: 63 AEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATE-PESVFALDVLRQRL 121
E K+ +K ++ E + ++ P + + E+ A V +
Sbjct: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
Query: 122 HEKIQEARGQGSAKEL-------SPAALE------KRRRRKQERDRKKRKRKELRAKEKA 168
E+++ RG+ ++E AALE KR R++ + ++++RK+ A K
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 169 RKAEEATEAQEVVEATPEGACTEPREPP--GLIFNKVEVSEDEPASKAQRRKEKRQRVKG 226
R+ EE +E +E A + ++ P GL +K P + + +E+ + +
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655
Query: 227 NLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVK 281
++ +G + SRL++ EG K ++L AEGV+
Sbjct: 656 SVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVR 710
Score = 36.6 bits (83), Expect = 0.036
Identities = 45/214 (21%), Positives = 81/214 (37%), Gaps = 15/214 (7%)
Query: 148 RKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR-----EPPGLIFNK 202
R++E R+KR+ L A+ A + + E + E R E G + ++
Sbjct: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
Query: 203 VEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ 262
VEV+ ++ + T + G + LERL R+ R + + + +
Sbjct: 66 VEVNAQNSVP------DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQ 322
E + + +L + ++ E E KE++ RQ R+E V K Q+
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTE----KEEKSESRQERYEIEETETVTKSYQKN 175
Query: 323 DRRRQNLRRKKAARAERRLLRARKKGRILPQDLE 356
D R +K+ E K+G I +E
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 62.0 bits (149), Expect = 8e-10
Identities = 66/314 (21%), Positives = 136/314 (43%), Gaps = 25/314 (7%)
Query: 43 PPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAK----EEAAWASSSAG 98
P +K++ Q+K +++EEK E + K ++ + K E+ W
Sbjct: 436 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 495
Query: 99 NPADG-LATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQER---DR 154
+ + + E ++ D +RL EK + R Q + E+++ ++QE+ D+
Sbjct: 496 RDQEQKMWDQEERMWEQD---ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQ 552
Query: 155 KKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVE-VSEDEPASK 213
+++ R+E R +E+ +K E E E + + RE ++ + E + E E
Sbjct: 553 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 214 AQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNL 273
Q K Q + + + +++ + + +E + E K +E E KM+
Sbjct: 613 EQEEKMWEQEEEDKM-----QEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEE 667
Query: 274 LYKAEGVKIRDDERLLQ----EALKRKEKRRAQRQRRW--EKRTAGVVEKM--QQRQDRR 325
+ + K+R+ E +Q + +++EK R Q ++ W E++ G EKM Q+ +
Sbjct: 668 KMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK 727
Query: 326 RQNLRRKKAARAER 339
+ +R +K ER
Sbjct: 728 EERIRDQKEKMQER 741
Score = 58.2 bits (139), Expect = 1e-08
Identities = 76/342 (22%), Positives = 147/342 (42%), Gaps = 40/342 (11%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKR--------------KKTQKKFRKREEKAAEHKAKSL 70
E++ R + GK + E ++KR + QKK R++EE+ E + K +
Sbjct: 261 EERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK-M 319
Query: 71 GEKSPAASGARRPEAAKEEAAWASSSAGNPAD-GLATEPESVFALDVLRQRLHEKIQEAR 129
E+ +EE W + + + E ++ D +RL EK + R
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD---ERLREKEERMR 376
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGAC 189
Q E E+ R R++E+ ++ + +EK +K EE QE E
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE------EKEW 430
Query: 190 TEPREPPGLIFNKVEVSEDEPASKAQRR---KEKRQRVKGNLTPLTGRNYRQLLERLQAR 246
+ R P K ++ E E + + + +E++ R + + + +RQ R Q
Sbjct: 431 QQQRLPE----QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 247 QSRLDELRGQD-EGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQR 305
Q E + +D E K + E +M + + + ++R+ +++ Q+ K +E+++ Q Q
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ- 545
Query: 306 RWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKK 347
EK+T EKM++ + R R+K R E ++R +++
Sbjct: 546 --EKKTWDQEEKMREEERMR----EREKKMREEEEMMREQEE 581
Score = 57.4 bits (137), Expect = 2e-08
Identities = 73/328 (22%), Positives = 140/328 (42%), Gaps = 35/328 (10%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ R + + + E ++K + QKK R++EE+ E + K + E+
Sbjct: 275 EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK-MWEQEEKMREQEEKM 333
Query: 85 AAKEEAAWASSSAGNPADG-LATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALE 143
+EE W + + + E ++ D +RL EK + R Q E E
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQD---ERLREKEERMREQEKMWEQEEKMQE 390
Query: 144 KRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKV 203
+ R R++E+ ++ + +EK +K EE QE E + E +E ++ +
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ-RLPEQKEK---LWEQE 446
Query: 204 EVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQE 263
++ E E Q K + Q + G+ + + R + + + D++ Q+E K ++
Sbjct: 447 KMQEQEEKIWEQEEKIRDQE------EMWGQEKK--MWRQEKMREQEDQMWEQEE-KMRD 497
Query: 264 LEAKMKWTNLLYKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWEKRTAGVVEKMQQR 321
E KM W +ER+ + E L+ KE+R ++++ W++ EK Q
Sbjct: 498 QEQKM-WDQ------------EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 322 QDRRRQNLRRKKAARAERRLLRARKKGR 349
Q+++ + K R E R+ KK R
Sbjct: 545 QEKKTWDQEEK--MREEERMREREKKMR 570
Score = 57.4 bits (137), Expect = 2e-08
Identities = 62/330 (18%), Positives = 144/330 (43%), Gaps = 44/330 (13%)
Query: 34 KTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAK------ 87
K Q E +KK ++ ++ R++EEK + + ++ R PE +
Sbjct: 387 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 446
Query: 88 -----EEAAWASSSAGNPADGLATEPESVFALDVLRQR---LHEKIQEARGQGSAKELSP 139
EE W + + + + ++ + +R++ + E+ ++ R Q
Sbjct: 447 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506
Query: 140 AALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLI 199
+ ++ R +E++ + R++K++ +E+ + E+ T+ QE E + RE +
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE---EKMREEERMR 563
Query: 200 FNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEG 259
+ ++ E+E + Q K + Q K R+ E++ ++ ++ E E
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEK----------MREQEEKMWEQEEKMQE----QEE 609
Query: 260 KAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQ 319
K E E KM W + E K+++ E ++ E ++EK + Q ++ WE+ EKM+
Sbjct: 610 KMWEQEEKM-WE----QEEEDKMQEQEEMMWE---QEEKMQEQEEKMWEQE-----EKMR 656
Query: 320 QRQDRRRQNLRRKKAARAERRLLRARKKGR 349
+++++ R+ + + + R + +G+
Sbjct: 657 EQEEKMREQEEKMQGQEEKMREQEEKMQGQ 686
Score = 51.2 bits (121), Expect = 1e-06
Identities = 68/310 (21%), Positives = 134/310 (43%), Gaps = 37/310 (11%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK--AKSLGEKSPAASGARRPEAAK--EEAAWASSSAGNP 100
KKK + Q+K R E + +E + K L K A +E W
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE----- 240
Query: 101 ADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRK 160
+ L + + + + R E+++E G+ +E EK RR+++ R + + K
Sbjct: 241 -EELREQEKKIRKQEEKMWRQEERLREQEGKMREQE------EKMRRQEK---RLREQEK 290
Query: 161 ELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK 220
ELR +EK + ++ QE E E E K+ E+ + ++ +E+
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350
Query: 221 RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGV 280
Q+++ + ++ ERL+ ++ R+ +++ K E E KM+ + + E
Sbjct: 351 EQKMRDQEERMWEQD-----ERLREKEERM-----REQEKMWEQEEKMQEEERIRERE-K 399
Query: 281 KIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNL-RRKKAARAER 339
K+R++E ++E ++EK + Q + WE+ E QQR +++ L ++K E
Sbjct: 400 KMREEEETMRE---QEEKMQKQEENMWEQEEK---EWQQQRLPEQKEKLWEQEKMQEQEE 453
Query: 340 RLLRARKKGR 349
++ +K R
Sbjct: 454 KIWEQEEKIR 463
Score = 36.2 bits (82), Expect = 0.047
Identities = 44/245 (17%), Positives = 97/245 (39%), Gaps = 43/245 (17%)
Query: 25 EQQART--RAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARR 82
EQ+ +T + K + E +KK ++ ++ R++EEK E + K + E+
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK-MREQEEKMWEQEE 602
Query: 83 PEAAKEEAAWASSSA---GNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSP 139
+EE W D + + E ++ + Q EK+ E
Sbjct: 603 KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE------------ 650
Query: 140 AALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLI 199
++ + R+QE ++++ K +EK R+ EE + QE
Sbjct: 651 ---QEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQE-------------------- 687
Query: 200 FNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGR-NYRQLLERLQARQSRLDELRGQDE 258
K+ E++ + ++ + +++ G + G+ R+ ER++ ++ ++ E + E
Sbjct: 688 -EKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Query: 259 GKAQE 263
+ E
Sbjct: 747 ERCSE 751
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 60.8 bits (146), Expect = 2e-09
Identities = 73/343 (21%), Positives = 129/343 (37%), Gaps = 41/343 (11%)
Query: 20 SHSAPEQQARTRAGKTQGSETAGPPK--KKRKKTQKKFRKREEKAAEHKAKSLGEKSPAA 77
S S+P+ +A+TR Q S + P+ K + + ++ R + K ++ +
Sbjct: 1559 SDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGS 1618
Query: 78 SGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKEL 137
+ P+A A S +G+ + G PE + + + + RG S+ E
Sbjct: 1619 DSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE- 1677
Query: 138 SPAALEKRRRRKQERDRKKRKRKELRAKEK-ARKAEEATEAQEVVEATPEGACTEPREPP 196
K + R R R R EL K + +R++ A+ + E TP P
Sbjct: 1678 -----PKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSP---- 1728
Query: 197 GLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQ 256
VS EPA K+ R +R+ T T R R S + RG
Sbjct: 1729 -------SVSSPEPAEKS-RSSRRRRSASSPRTKTTSRRGR----------SPSPKPRGL 1770
Query: 257 DEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQ-RQRRWEKRTAGVV 315
+++ K + T + RD Q +R+++ R++ R R + +G
Sbjct: 1771 QRSRSRSRREKTRTT---------RRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYH 1821
Query: 316 EKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERA 358
+ RQ+ R + RR++ R R + R P +R+
Sbjct: 1822 SRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRS 1864
Score = 38.5 bits (88), Expect = 0.009
Identities = 45/191 (23%), Positives = 74/191 (38%), Gaps = 20/191 (10%)
Query: 20 SHSAPEQQARTRAGKTQG--SETAGP-------PKKKRKKTQKKFRKREEKAAEHKAKSL 70
S S +Q + + K +G SE++ P KKK+ +++ + +KR+ ++ K+K
Sbjct: 180 SRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRK 239
Query: 71 GEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFA-----LDVLRQRLHEKI 125
+ A K A S+SA + + + S A L R
Sbjct: 240 SKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPA 299
Query: 126 QEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATP 185
RG+G A P +R E K+ K+K +K + AT +P
Sbjct: 300 SGRRGEGDAPFSEPGTTSTQRPSSPE-TATKQPSSPYEDKDKDKKEKSATRP----SPSP 354
Query: 186 EGACTEPREPP 196
E + T P EPP
Sbjct: 355 ERSSTGP-EPP 364
Score = 35.8 bits (81), Expect = 0.061
Identities = 52/294 (17%), Positives = 96/294 (32%), Gaps = 33/294 (11%)
Query: 66 KAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKI 125
+A ++SP S + P+++ E++ S + ++ PES
Sbjct: 396 EASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESP-------------- 441
Query: 126 QEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATP 185
+ A GS +E+S + K R + + K R ++R A +
Sbjct: 442 KPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPT 501
Query: 186 EGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQA 245
+ + R P + + + + R QR + + T R R R
Sbjct: 502 KRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGR 561
Query: 246 RQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQR 305
SR RG+ + + + + +R+ + R +R
Sbjct: 562 SHSRSPATRGRSRSRTPARRGRSR-------------------SRTPARRRSRSRTPTRR 602
Query: 306 RWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAG 359
R RT + + R RR++ R R R AR+ GR + R G
Sbjct: 603 RSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRG 656
Score = 32.0 bits (71), Expect = 0.88
Identities = 44/251 (17%), Positives = 97/251 (38%), Gaps = 7/251 (2%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
+A ++R+R +G + P+ +R ++ +++ + ++ + + +S + P S +R
Sbjct: 489 TAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGR--SRSPQRRGRSRSPQRPGWSRSR 546
Query: 82 RPE--AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSP 139
+ A S + +PA + + R R + + +R + + S
Sbjct: 547 NTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPAR-RRSRSRTPTRRRSR 605
Query: 140 AALEKRRRRKQERD-RKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGL 198
+ RR R + R ++R R + ++R A + TP P
Sbjct: 606 SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPAR 665
Query: 199 IFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDE 258
+ + +++ R R+ + TP GR+ + L R SR + RG+
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGR-S 724
Query: 259 GKAQELEAKMK 269
G + E + K +
Sbjct: 725 GSSSERKNKSR 735
Score = 30.8 bits (68), Expect = 2.0
Identities = 48/245 (19%), Positives = 88/245 (35%), Gaps = 39/245 (15%)
Query: 20 SHSAPEQQARTRAGKTQGSETAGPPKKK---RKKTQKKFRKREEKAAEHKAKSLGEKSPA 76
S SA ++ +R+ T+G + P ++ R +T + R R +++S ++PA
Sbjct: 554 SRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRS---RTPA 610
Query: 77 ASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKE 136
G R + S +R+R + AR G ++
Sbjct: 611 RRGRSRSRTPARRRSRTRSP--------------------VRRRSRSR-SPARRSGRSRS 649
Query: 137 LSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPRE-- 194
+PA + R R R + R R R ++R A + TP + R
Sbjct: 650 RTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRS-RSRTPRRGRSRSRSLV 708
Query: 195 PPGLIFNKVEVSEDEPASKAQRRKEKR---QRVKGNLTP------LTGRNYRQLLERLQA 245
G ++ S ++R+ + R +R + N +P ++ R R L
Sbjct: 709 RRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSK 768
Query: 246 RQSRL 250
+SRL
Sbjct: 769 AKSRL 773
Score = 29.6 bits (65), Expect = 4.4
Identities = 48/247 (19%), Positives = 92/247 (37%), Gaps = 36/247 (14%)
Query: 20 SHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAK-----SLGEKS 74
S S+ E++ ++R + + + P KK + + ++ R ++ K++ SL S
Sbjct: 724 SGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSS 783
Query: 75 P------------AASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLH 122
P + SG+ +P+A S S+ +P ++ S H
Sbjct: 784 PCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPS--RQSHSSSSPH 841
Query: 123 EKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVE 182
K++ SP A E+ ++ + EL+++ +R + + V
Sbjct: 842 PKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKS 901
Query: 183 ATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLER 242
+TP PR+ P S +P KA +R G+ +P R + R
Sbjct: 902 STP------PRQSPS------RSSSPQPKVKAIISPRQRSH-SGSSSPSPSR----VTSR 944
Query: 243 LQARQSR 249
R+SR
Sbjct: 945 TTPRRSR 951
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 60.1 bits (144), Expect = 3e-09
Identities = 50/223 (22%), Positives = 101/223 (45%), Gaps = 17/223 (7%)
Query: 122 HEKIQEARGQGSAKELSPAALEKRRR---RKQERDRKKRKRKELRAKEKARKAEEATEAQ 178
H+K++E +G+ KE +EK RR R++ER+R++R+R+ R +E+ R+ E+ E +
Sbjct: 288 HKKLEEEKGK---KEKERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + R+ + + D S + + R R K R +
Sbjct: 345 RERDRDRDRTKERDRDRD----RERDRDRDRERSSDRNKDRSRSREKSR-----DRERER 395
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEK 298
ER + R+ + R ++ + +E E + + + E + + R L+ L+ KE
Sbjct: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455
Query: 299 RRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRL 341
+R + WE R + ++ +R + RR++ A+ +RL
Sbjct: 456 AYQERLKNWEIRERKKTREYEKEAEREEE--RRREMAKEAKRL 496
Score = 50.1 bits (118), Expect = 3e-06
Identities = 72/346 (20%), Positives = 141/346 (40%), Gaps = 62/346 (17%)
Query: 39 ETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAG 98
E G +K+R++ +K+ R+RE + + + E+ R E +E
Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERER--------- 343
Query: 99 NPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRK 158
E E D ++R ++ +E + S ++ R R++ RDR++ +
Sbjct: 344 --------ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395
Query: 159 RKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRK 218
+E R +E+ R+ E E + E E RE K + EDE + +R+
Sbjct: 396 ERE-RERERERERERERERERERERERE----REREKD----KKRDREEDEEDAYERRKL 446
Query: 219 EKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAE 278
E++ R K +N+ ++ ER + R+ + R ++ + EAK E
Sbjct: 447 ERKLREKEAAYQERLKNW-EIRERKKTREYEKEAEREEERRREMAKEAKR-------LKE 498
Query: 279 GVKIRDDER---------LLQEALKRKEKRRA--QRQRRWEKRTA--------------- 312
++ DD+R LQ+ L+ +EK +R R+ EK
Sbjct: 499 FLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDP 558
Query: 313 -GVVEKMQQRQDRRRQ-NLRRKKAARAERRLLRARKKGRILPQDLE 356
+++M+Q +RRRQ ++++ + E + +++ R P + E
Sbjct: 559 DAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604
Score = 40.4 bits (93), Expect = 0.002
Identities = 59/301 (19%), Positives = 129/301 (42%), Gaps = 29/301 (9%)
Query: 45 KKKRKKTQKKFRKRE-EKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADG 103
+++R++ +++ R+RE EK E + + ++ R + ++ S+ D
Sbjct: 322 RREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
Query: 104 LATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKK------- 156
+ +S D R+R E+ +E + + E+ R R++E+D+K+
Sbjct: 382 SRSREKS---RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE 438
Query: 157 ----RKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPAS 212
R++ E + +EK +E + E+ E + E + E E A
Sbjct: 439 DAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAE-------REEERRREMAK 491
Query: 213 KAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTN 272
+A+R KE + + L +RL+ R+ ++ + + +ELE +
Sbjct: 492 EAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQ--R 549
Query: 273 LLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRK 332
LL AEG D E + ++++ +RR Q Q + E + E+ Q+++++R + + +
Sbjct: 550 LL--AEGHPDPDAE---LQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604
Query: 333 K 333
+
Sbjct: 605 E 605
Score = 37.7 bits (86), Expect = 0.016
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 274 LYKAEGVKIRDDERLLQEALKRKEKRR--AQRQRRWEKRTAGVVEKMQQRQDRRRQNLRR 331
L E K RD + L+E +KEK R +++RR +R + ++R+ R + R
Sbjct: 276 LISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERER 335
Query: 332 KKAARAERRLLRARKKGRILPQDLER 357
+K ER R R + R +D +R
Sbjct: 336 EKEKERERERERDRDRDRTKERDRDR 361
Score = 32.0 bits (71), Expect = 0.88
Identities = 38/159 (23%), Positives = 69/159 (43%), Gaps = 14/159 (8%)
Query: 46 KKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLA 105
++RKKT +++ K E+ E + + E + +++ + SA L
Sbjct: 467 RERKKT-REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR--LR 523
Query: 106 TEPESVFALDVLRQRLHEKIQEARGQGSAK-------ELSPAALE-KRRRRKQERDRKKR 157
+ + A + R+R E+++E R + A+ EL E +RRR+ Q + +
Sbjct: 524 DREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES 583
Query: 158 KRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPP 196
+ +E +EK K EE E +E E P C +P P
Sbjct: 584 EEEEEEKQEKEEKREEPMEEEEEPEQKP---CLKPTLRP 619
Score = 31.2 bits (69), Expect = 1.5
Identities = 25/110 (22%), Positives = 50/110 (45%), Gaps = 21/110 (19%)
Query: 240 LERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKR 299
+ + + +L+E +G+ E + QE+E + R+ ER E + +E+R
Sbjct: 281 ISKFRDTHKKLEEEKGKKEKERQEIEKER--------------RERER---ERERERERR 323
Query: 300 RAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
+R+R E+ EK ++R+ R ++ R + +R R R + R
Sbjct: 324 ERERERERERER----EKEKERERERERDRDRDRTKERDRDRDRERDRDR 369
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1987
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2039
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2159 QKQAADAE 2166
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1502 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1679
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1740 QREAAAATQKRQELEAELAK 1759
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2265 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2379 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2433
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2434 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2479
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2527
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2586
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2587 LAEENQR 2593
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1522 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1581 KRASFAEK 1588
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1739
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2027
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2322 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2375
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2376 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2435 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2552 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2689
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2690 HYLQGRSSIAGLLLKATNEKL 2710
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1345 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRAR 1481
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1882 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1942 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1991
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2043
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2103
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2163 QKQAADAE 2170
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1506 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1683
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1744 QREAAAATQKRQELEAELAK 1763
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2269 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2323 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2383 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2437
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2438 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2483
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2531
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2590
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2591 LAEENQR 2597
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1526 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1585 KRASFAEK 1592
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1743
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2031
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2326 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2379
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2380 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2438
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2439 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2555
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2556 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2639
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2640 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2693
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2694 HYLQGRSSIAGLLLKATNEKL 2714
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1349 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRAR 1485
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1878 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1938 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1987
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2039
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2099
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2159 QKQAADAE 2166
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1502 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1679
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1740 QREAAAATQKRQELEAELAK 1759
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2265 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2379 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2433
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2434 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2479
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2527
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2586
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2587 LAEENQR 2593
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1522 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1581 KRASFAEK 1588
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1739
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2027
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2322 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2375
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2376 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2435 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2552 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2689
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2690 HYLQGRSSIAGLLLKATNEKL 2710
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1345 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRAR 1481
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1846 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1906 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1955
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2007
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2067
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2127 QKQAADAE 2134
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1470 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1647
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1708 QREAAAATQKRQELEAELAK 1727
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2233 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2287 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2347 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2401
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2402 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2447
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2495
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2554
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2555 LAEENQR 2561
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1490 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1549 KRASFAEK 1556
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1707
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1887
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 1995
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2290 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2343
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2344 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2402
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2403 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2519
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2520 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2603
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2604 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2657
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2658 HYLQGRSSIAGLLLKATNEKL 2678
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1313 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRAR 1449
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 2015 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 2124
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2176
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2236
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2296 QKQAADAE 2303
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1639 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1816
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1877 QREAAAATQKRQELEAELAK 1896
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2402 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2516 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2570
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2571 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2616
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2664
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2723
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2724 LAEENQR 2730
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1659 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1718 KRASFAEK 1725
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1876
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 2056
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2164
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2459 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2512
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2513 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2571
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2572 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2688
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2689 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2772
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2773 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2826
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2827 HYLQGRSSIAGLLLKATNEKL 2847
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1482 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRAR 1618
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1856 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1965
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2017
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2077
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2137 QKQAADAE 2144
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1480 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1657
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1718 QREAAAATQKRQELEAELAK 1737
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2243 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2297 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2357 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2411
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2412 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2457
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2505
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2564
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2565 LAEENQR 2571
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1500 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1559 KRASFAEK 1566
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1717
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1897
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2005
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2300 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2353
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2354 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2412
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2413 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2529
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2530 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2613
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2614 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2667
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2668 HYLQGRSSIAGLLLKATNEKL 2688
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1323 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRAR 1459
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1864 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1923
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1924 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 1973
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2025
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2085
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2145 QKQAADAE 2152
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1488 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1665
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1726 QREAAAATQKRQELEAELAK 1745
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2251 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2305 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2365 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2419
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2420 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2465
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2513
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2572
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2573 LAEENQR 2579
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1508 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1567 KRASFAEK 1574
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1725
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1905
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2013
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2308 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2361
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2362 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2420
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2421 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2537
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2538 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2621
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2622 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2675
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2676 HYLQGRSSIAGLLLKATNEKL 2696
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1331 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRAR 1467
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 60.1 bits (144), Expect = 3e-09
Identities = 82/308 (26%), Positives = 129/308 (41%), Gaps = 44/308 (14%)
Query: 56 RKREEKAAEHKA--------------------KSLGEKSPAASGARRPEAAKEEAAWASS 95
R+ EE+AA+HKA K L E + E +A++ +
Sbjct: 1905 RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1964
Query: 96 SAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
+AG L A D LR + +++ AR + A E E+RRRR+ E
Sbjct: 1965 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------EERRRREAE---- 2014
Query: 156 KRKRKELRAKEKA-RKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKA 214
+R +K L A+E+A R+ + A E E ++A E A + + E A
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--------LRERAEQESARQLQLA 2066
Query: 215 QRRKEKRQRVKGNLTPLTGRNYRQLLER-LQARQSRLDELRGQDEGK---AQELEAKMKW 270
Q +KR + + + Q L++ LQ QS LD+LRG+ E A+E E
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQ 2126
Query: 271 TNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLR 330
++ + ERL Q A + + + RAQ Q EK ++ +R + LR
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSA-EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185
Query: 331 RKKAARAE 338
+K+AA AE
Sbjct: 2186 QKQAADAE 2193
Score = 50.1 bits (118), Expect = 3e-06
Identities = 79/380 (20%), Positives = 143/380 (37%), Gaps = 39/380 (10%)
Query: 15 AKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRK-REEKAAEHKAKSLGEK 73
AK A E Q R + + E A +++++ Q++ ++ R+ AE +AK+ +
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468
Query: 74 SPAASGARRPEAAK------EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQE 127
+ S R E + E A L E A Q E+++
Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 128 ARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKAR-------------KAEEA 174
+ Q ++ A +E R K E + + K++ L+A E+ R + E A
Sbjct: 1529 -QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 175 TEAQEVVEATPEGACTEPREPPGLIFNKVEVSE----DEPASKAQRRKEKRQRVKGNLTP 230
+ Q +E A E + K E +E + AQ R+E +R +
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 231 LTGRNYRQ-------------LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKA 277
R + L RLQA + + Q E + Q+ EA+ + KA
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE-ARRRGKA 1706
Query: 278 EGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
E +R E QE K+++ Q+R + + + Q +++ L ++ AR
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 338 ERRLLRARKKGRILPQDLER 357
+R A +K + L +L +
Sbjct: 1767 QREAAAATQKRQELEAELAK 1786
Score = 47.8 bits (112), Expect = 2e-05
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 57/367 (15%)
Query: 10 YLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKS 69
+LQ A+K+ +Q A A + ++ A ++ ++ + R EK + K ++
Sbjct: 2292 FLQEEAEKM------KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 70 LGE----KSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVF-ALDVLRQRLHEK 124
+ E K+ A ++ E A+E+A A LA E + L+ RQR E
Sbjct: 2346 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEAT 184
EA +L A + + + R +E ++ RK+ E EK + E AT+ + + T
Sbjct: 2406 SAEAE----RLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLHRTELATQEKVTLVQT 2460
Query: 185 PEGACTEPREPPGLIFNKVEVSED-----EPASKAQRRKEKRQRVKGNLTPLTGRNYR-- 237
E + + D E ++ +R KEK Q+ + L L +
Sbjct: 2461 LE-------------IQRQQSDHDAERLREAIAELEREKEKLQQ-EAKLLQLKSEEMQTV 2506
Query: 238 ---QLLERLQARQ----SRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
QLL+ QA Q S D L ++ QE KA+ ++ DE
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQE------------KAKLEQLFQDEVAKA 2554
Query: 291 EALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRI 350
+ L+ +++R+ Q+ + +R +E+ ++RQ + +RRK+ + R R++ +
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR-RQQEEL 2613
Query: 351 LPQDLER 357
L ++ +R
Sbjct: 2614 LAEENQR 2620
Score = 45.1 bits (105), Expect = 1e-04
Identities = 60/248 (24%), Positives = 116/248 (46%), Gaps = 28/248 (11%)
Query: 118 RQRLHEKIQEARGQGSAKELSP--AALEKRRR----RKQERDRKKRKRKEL--RAKEKAR 169
R E++ E + + L+ AALEK+R+ Q + + +R+ KEL R +E+
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 170 KAEEAT------------EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRR 217
+ EEA E Q++ +++ + R+ +++ + E+ + Q
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 218 KEKRQR--VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQ-ELEAKMKWTNLL 274
+RQR +G L L R ++ QA Q + LR Q + ++Q + +A+++ + +
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQA-QEEAERLRRQVQDESQRKRQAEVELASRV 1548
Query: 275 YKAEGVKIRDDERLLQ--EALKRKEKRRAQRQRRWE-KRTAGVVEKMQQRQDRRRQNLRR 331
KAE R+ +R LQ E L+ + + +R R+ E +R V ++ Q L+
Sbjct: 1549 -KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 332 KKAARAER 339
K+A+ AE+
Sbjct: 1608 KRASFAEK 1615
Score = 41.2 bits (95), Expect = 0.001
Identities = 75/349 (21%), Positives = 138/349 (39%), Gaps = 18/349 (5%)
Query: 12 QSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLG 71
Q++ ++ + E+Q + G Q A + R + + + +++ + E + L
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARL- 1766
Query: 72 EKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEAR-- 129
++ AA+ +R E E A + A E ES + +QRL + R
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA-KEKARKAEEATEAQEVVEATPEGA 188
+ +A+ + A KR+R+ E D +++ + R EK EAT + E +
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 189 CTEPREPPGLI----FNKVEVSEDEPASKA---QRRKEKRQRVKGNLTPLTGRNYRQLLE 241
E L F + + E KA +R + R+ L G L +
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1946
Query: 242 RLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRK----- 296
R Q + L ++ A + E +++ + AE ++ L+ A +R+
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 297 EKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRAR 345
E+RR + + R +K A E +QR+ + + R KA E R LR R
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEEARRLRER 2054
Score = 40.4 bits (93), Expect = 0.002
Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 14/293 (4%)
Query: 2 ASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK 61
A+ L +A L K++ A EQ R + K Q ++ + ++T + R+R+
Sbjct: 2349 ATRLKAEAELLQQQKEL----AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ-- 2402
Query: 62 AAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRL 121
E A++ K A +R A+E+A A + L + L Q L
Sbjct: 2403 -LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2461
Query: 122 HEKIQEARGQGSAKELSPAALEKRRRRK---QERDRKKRKRKELRAKEKARKAEEATEAQ 178
+IQ + A+ L A E R ++ QE + K +E++ ++ + +E Q
Sbjct: 2462 --EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
+ + + R ++ +DE A KAQ+ +E++QR + + R
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA-KAQQLREEQQRQQQQMEQERQRLVAS 2578
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
+ E + RQ +E + + + Q+LE + + L E ++R+ +LL+E
Sbjct: 2579 M-EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630
Score = 38.9 bits (89), Expect = 0.007
Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 41/261 (15%)
Query: 57 KREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEP-------- 108
+RE++ + +AK L KS ++ + +E A S L E
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542
Query: 109 -ESVFALDVLR-QRLHEKIQEARGQ-GSAKELSPAALEKRRRRKQERDRK-KRKRKELRA 164
E +F +V + Q+L E+ Q + Q ++ A++E+ RRR+ E + +RK++EL+
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Query: 165 KEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN-KVEVSE--------------DE 209
E+ R+ +E A+E + E + L + +V S+ D
Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2662
Query: 210 PASKAQ--------RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
PA++A+ RRK QR++ G + L+RL + +DEL +++ +
Sbjct: 2663 PAAEAEPEHSFDGLRRKVSAQRLQE-----AGILSAEELQRLAQGHTTVDELARREDVR- 2716
Query: 262 QELEAKMKWTNLLYKAEGVKI 282
L+ + LL KA K+
Sbjct: 2717 HYLQGRSSIAGLLLKATNEKL 2737
Score = 32.7 bits (73), Expect = 0.52
Identities = 32/146 (21%), Positives = 66/146 (45%), Gaps = 16/146 (10%)
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEA 266
E+E Q+R E+R+R+ LE+ + + + Q E +A+EL+
Sbjct: 1372 EEEERLAEQQRAEERERLA---------EVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 267 KMKWTNLLYKAEGVKIRDDERLLQEALKR-KEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ + + V + +R +QE L++ ++ A+ Q + + A +++ ++ R
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482
Query: 326 RQNL------RRKKAARAERRLLRAR 345
L R++ A E + LRAR
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRAR 1508
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 59.7 bits (143), Expect = 4e-09
Identities = 74/359 (20%), Positives = 158/359 (44%), Gaps = 42/359 (11%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ R + K Q E +KK ++ ++ R++EEK + + ++ R PE
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 85 -----------AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQ---RLHEKIQEARG 130
+EE W + + + + ++ + +R+ ++ E+ ++ R
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555
Query: 131 QGSAKELSPAALEKRRRRKQER--DRKKRKRKELRAKE---KARKAEEATEAQEVVEATP 185
Q +EK+ + ++++ D++++ R+E R +E K R+ EE QE
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 186 EGACTEPREPPGLIFNKVEVSED---EPASKAQRRKEK---RQRVKGNLTPLTGRNYRQL 239
E E E K++ E+ E K ++EK +QR+ L Q
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675
Query: 240 LERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGV-----KIRDDERLLQE--- 291
E++Q ++ ++ E + + E K QE E K + + E + K+R++E +++E
Sbjct: 676 QEKMQEQEEKIWE-QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 292 -ALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDR--RRQNLRRKKAARAERRLLRARKK 347
+++EK + Q + WE+ EKM +++++ +Q L +K E ++ ++K
Sbjct: 735 KMQEQEEKMQEQEEEMWEQE-----EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Score = 58.5 bits (140), Expect = 9e-09
Identities = 74/336 (22%), Positives = 147/336 (43%), Gaps = 37/336 (11%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ R + GK + E ++KR + Q+K + +EK + K L E+
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ-KELREQEEQMQ------ 351
Query: 85 AAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEK 144
+EE W + E L +++ E+ Q+ R Q L +
Sbjct: 352 -EQEEKMWEQEEKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEERMWEQDERLRE 408
Query: 145 RRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVE 204
+ R +E+++ + +++R ++K ++ E+ T QE E E RE +
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE--EKMQEEERIREREK--------K 458
Query: 205 VSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRL--DELRGQDEGKAQ 262
+ E+E + Q +EK Q+ + N+ + ++Q +RL ++ +L E + E K
Sbjct: 459 MREEEETMREQ--EEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIW 514
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQE--ALKRKEKRRAQRQRRW------EKRTAGV 314
E E K++ ++ E R ++ QE +++EK R Q Q+ W EK+T
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574
Query: 315 VEKMQQRQDRRRQNLR---RKKAARAERRLLRARKK 347
+K ++++ R+ R R+K R E ++R +++
Sbjct: 575 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Score = 50.8 bits (120), Expect = 2e-06
Identities = 60/247 (24%), Positives = 108/247 (43%), Gaps = 34/247 (13%)
Query: 121 LHEKIQEARGQGSAKELSPAALEKRRRRKQE----------RDRKKRKRKELRAKEKA-R 169
L EK+ A + S +L+ L+++ R + ++ R+ +ELR +EK R
Sbjct: 230 LQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR 289
Query: 170 KAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLT 229
K EE QE EG E E ++ E E R +EK R + L
Sbjct: 290 KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE-----LREQEKELREQKEL- 343
Query: 230 PLTGRNYRQLLERLQARQSRL----DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDD 285
R+ E++Q ++ ++ +++R Q+E K E ++ + + K+RD
Sbjct: 344 -------REQEEQMQEQEEKMWEQEEKMREQEE-KMWRQEERLWEQEKQMREQEQKMRDQ 395
Query: 286 ERLL---QEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLL 342
E + E L+ KE+R ++++ WE+ EK Q Q+++ ++ K + E R+
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK--MQEEERIR 453
Query: 343 RARKKGR 349
KK R
Sbjct: 454 EREKKMR 460
Score = 50.1 bits (118), Expect = 3e-06
Identities = 51/224 (22%), Positives = 105/224 (46%), Gaps = 27/224 (12%)
Query: 120 RLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQE 179
R E+++E G+ +E EKR R +++ R++ K ELR +++ R+ EE + QE
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK--ELREQKELREQEEQMQEQE 354
Query: 180 VVEATPEGACTEP-----REPPGLIFNKVEVSEDEPASKAQ-----------RRKEKRQR 223
E E R+ L + ++ E E + Q R KE+R R
Sbjct: 355 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414
Query: 224 VKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKI- 282
+ + + + + Q +++R E + Q+E + +E E KM+ + + K+
Sbjct: 415 EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ 474
Query: 283 RDDERLLQEALKRKEKRR--AQRQRRWEKRTAGVVEKMQQRQDR 324
+ +E + ++ K +++R Q+++ WE+ EKMQ+++++
Sbjct: 475 KQEENMWEQEEKEWQQQRLPEQKEKLWEQ------EKMQEQEEK 512
Score = 40.0 bits (92), Expect = 0.003
Identities = 49/291 (16%), Positives = 124/291 (42%), Gaps = 33/291 (11%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRK-KTQKKFRKREEKAAEHKAKSLGEKSPAASGARRP 83
E+ R + K Q E ++++ + ++K +++EEK E + K ++ R P
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 84 EAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALE 143
E ++E W + + + E ++ + + ++ E+ ++ Q +E
Sbjct: 662 E--QKEKLWEHEKM-QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 144 KRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGL---IF 200
+++ R++E ++++ K +EK ++ EE QE E E + P ++
Sbjct: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 201 NKVEVSEDEPA-SKAQRRKEKRQRVKGNLTPLTGRNYRQL-------------------- 239
++ E E + ++ +++ ++++G + G+ +
Sbjct: 779 EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKM 838
Query: 240 ---LERLQARQSRLDE-LRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDE 286
E++ ++ +++E ++GQ+E K +E E KM+ + + K+R E
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEE-KMREQEEKMRGQEEKMREQEEKMRGQE 888
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 59.7 bits (143), Expect = 4e-09
Identities = 89/351 (25%), Positives = 146/351 (41%), Gaps = 42/351 (11%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEH-------KAKSLGEKS 74
SA +Q+A+T Q PP+ R+K K E +H +S S
Sbjct: 426 SAGQQEAKT----DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSS 481
Query: 75 PA-ASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQ---RLHEKIQEARG 130
P AS RP + P P SV + R R+ K +E +
Sbjct: 482 PCPASKVVRPLRTFLHTVQRNQMLMTPTSA----PRSVMKSFIKRNTPLRMDPKEKERQR 537
Query: 131 QGSAKELSPAALEKRRRRKQERDRKKRKRK-ELRAKEKARKAEEATEAQEVVEATPEGAC 189
+ + A E+ RR+K E D+++R + +L+ +E+ RK +A+E VE E
Sbjct: 538 LENLRRKEEA--EQLRRQKVEEDKRRRLEEVKLKREERLRKV---LQARERVEQMKEEKK 592
Query: 190 TEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSR 249
+ + I K E +++E A+ + +K+ K R + RL+ Q
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERL--AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 650
Query: 250 LDELRGQD---EGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRR 306
+E R Q+ + K +E E K AE R+ ER QE +R+++RR Q +R
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ---REQERREQE--RREQERREQERRE 705
Query: 307 WEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLER 357
E+R Q+RQ ++ R ++ +AER L K R+ + L+R
Sbjct: 706 QERRE-------QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 749
Score = 59.3 bits (142), Expect = 5e-09
Identities = 83/380 (21%), Positives = 148/380 (38%), Gaps = 52/380 (13%)
Query: 4 LLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAA 63
L K A + + +I HS E+ + GSE PP++ + E
Sbjct: 339 LAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGN 398
Query: 64 E-------HKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESV----- 111
A S PAAS P A ++EA + ADG P+S
Sbjct: 399 NSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA------KTDQADGPREPPQSARRKRS 452
Query: 112 --FALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRR------RKQERDR--------- 154
A+ L + H + +E + S SP K R +R++
Sbjct: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAP 512
Query: 155 --------KKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVS 206
K+ + KEK R+ E +E E E + +V++
Sbjct: 513 RSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRR---LEEVKLK 569
Query: 207 EDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQ-ARQSRLDELRGQDEG---KAQ 262
+E K + +E+ +++K + + Q+ E+ + A++ RL E + + + K +
Sbjct: 570 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 629
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRR--WEKRTAGVVEKMQQ 320
E+EA+ K + ++ ++ER QE L++K++ +R R+ KR A E+ ++
Sbjct: 630 EVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERR 689
Query: 321 RQDRRRQNLRRKKAARAERR 340
Q+RR Q R ++ ERR
Sbjct: 690 EQERREQERREQERREQERR 709
Score = 53.1 bits (126), Expect = 4e-07
Identities = 54/233 (23%), Positives = 107/233 (45%), Gaps = 37/233 (15%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKE----EAAWASSSAGNP 100
++K+K+ ++KF + +EK + K + L E+ A++ AAK+ EA
Sbjct: 589 EEKKKQIEQKFAQIDEKTEKAKEERLAEEK-----AKKKAAAKKMEEVEARRKQEEEARR 643
Query: 101 ADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRK 160
L E E +R H+++ + + + + L AA KR ++E++R++++R+
Sbjct: 644 LRWLQQEEE---------ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694
Query: 161 ELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK 220
E +E+ R+ +E E + + A E R + + E+ E E A + Q+ + +
Sbjct: 695 EQERREQERREQERREQERQL------AEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Query: 221 RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNL 273
R+ L + ++ +RL RQ L+ + E KA+E K N+
Sbjct: 749 RE--------LEEKKKKEEQQRLAERQ-----LQEEQEKKAKEAAGASKALNV 788
Score = 35.8 bits (81), Expect = 0.061
Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 22/159 (13%)
Query: 45 KKKRKKTQKKFRKR-------EEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSA 97
+KK+++ Q++ RK E++ E + + E+ R E ++E A
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
Query: 98 GNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKR 157
+ L E E L E+ + R Q KE LE++++ K+E+ R
Sbjct: 721 RREQERLQAERE-----------LQEREKALRLQ---KEQLQRELEEKKK-KEEQQRLAE 765
Query: 158 KRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPP 196
++ + ++KA++A A++A V ACT + P
Sbjct: 766 RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTP 804
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 59.3 bits (142), Expect = 5e-09
Identities = 78/344 (22%), Positives = 148/344 (43%), Gaps = 34/344 (9%)
Query: 11 LQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSL 70
LQS++ K+ + E + R + Q E ++K ++ ++K +++EEK E + K
Sbjct: 274 LQSVSAKLQAQ-VEENELWNRLNQQQ-EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 71 GEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFA-LDVLRQRLHEKIQEAR 129
++ RR +EE W + + E E L+ + EKI+E
Sbjct: 332 EQEEKM----RR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 130 GQGSAKELSPAALEKRRRRKQERDRKKRKRKEL---RAKEKARKAEEATEAQEVVEATPE 186
+ +E EKR+ ++ R+++KR+ +E R +EK R+ EE QE E
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 187 GACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ-LLERLQA 245
E K+ E + R+E++ R + + + + Q + + +
Sbjct: 444 EKIHEQ--------EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 246 RQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQR 305
+ R +E E K +E E KM + + KIR+ E ++E ++E + Q ++
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE---QEEMMQEQEEK 552
Query: 306 RWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
E+ EKMQ+++ RRQ +K E ++ ++K R
Sbjct: 553 MGEQE-----EKMQEQEKMRRQ---EEKIREQEEKIREQKEKIR 588
Score = 57.4 bits (137), Expect = 2e-08
Identities = 72/335 (21%), Positives = 145/335 (43%), Gaps = 39/335 (11%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
++K ++ ++K R++EEK E + K ++ + +EE W + +
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRLEEM 371
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQE----RDRKKRKRK 160
E E + L +++HE+ ++ R Q ++ E+ +R++QE R +K + +
Sbjct: 372 MWEKEE--KIRELEEKMHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 428
Query: 161 ELRAKEKARKA---EEATEAQEVVEATPEGACTEP--------REPPGLIFNKVEVSEDE 209
E + +E+ +K EE QE + + E RE + K ++ E E
Sbjct: 429 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE 488
Query: 210 PASKAQ----RRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRL----------DELRG 255
K + R++EK + + + +RQ E+++ ++ ++ +E+
Sbjct: 489 KIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE-EKIREQEEKIREQEEKIREQEEMMQ 547
Query: 256 QDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWE-KRTAGV 314
+ E K E E KM+ + + E KIR+ E ++E +KEK R Q ++ WE +
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEE-KIREQEEKIRE---QKEKIREQEEKIWEQEEKIRE 603
Query: 315 VEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
E+M Q Q+ + K + E+ + K R
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 638
Score = 52.4 bits (124), Expect = 6e-07
Identities = 52/242 (21%), Positives = 109/242 (45%), Gaps = 30/242 (12%)
Query: 120 RLHEKIQEARGQGSAKELSPAALEKRRRRKQ----------ERDRKKRKRKELRAKEKAR 169
+L EK+Q + S +L+ L+++ R + E D ++ + + AK +A+
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 170 KAEEA-----TEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRV 224
E + QE E E E + + ++ E E + Q K +RQ
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEK--IQEQEEKIREQEEKIREQEEKMRRQEE 342
Query: 225 KGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRD 284
R +++ + + RL+E+ + E K +ELE KM ++ E ++ ++
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKM------HEQEKIREQE 396
Query: 285 DERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRA 344
++R +E ++ +EKR+ Q + W + EK+++++++ R+ + KK R E ++
Sbjct: 397 EKRQEEEKIREQEKRQEQEAKMWRQE-----EKIREQEEKIRE--QEKKMWRQEEKIHEQ 449
Query: 345 RK 346
K
Sbjct: 450 EK 451
Score = 51.6 bits (122), Expect = 1e-06
Identities = 54/270 (20%), Positives = 112/270 (41%), Gaps = 8/270 (2%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
+++ R K + E + K + ++K R++EEK E + K ++ + E
Sbjct: 395 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 85 AAK---EEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAA 141
K +E W + + + E + + +R++ EK+ + +E
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ-EEKVWRQEEKMHDQEEKIRE 513
Query: 142 LEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFN 201
E++ R++E+ R++ + K +EK R+ EE + QE E E + +
Sbjct: 514 QEEKMWRQEEKIREQEE-KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEK---MRRQ 569
Query: 202 KVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKA 261
+ ++ E E + Q+ K + Q K R ++++ + + +E + E K
Sbjct: 570 EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Query: 262 QELEAKMKWTNLLYKAEGVKIRDDERLLQE 291
QE E KM+ + V++R E +QE
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 40.0 bits (92), Expect = 0.003
Identities = 47/208 (22%), Positives = 81/208 (38%), Gaps = 23/208 (11%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSA-GNPADG 103
+K++ Q+K RK+EEK + K ++ +EE W +
Sbjct: 480 QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE--------QEEKMWRQEEKIREQEEK 531
Query: 104 LATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELR 163
+ + E + + + Q EK+ E + E+ + R+QE ++++ K
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQ---------EQEKMRRQEEKIREQEEKIRE 582
Query: 164 AKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQR 223
KEK R+ EE QE E E E + E E K Q ++EK +R
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEMMQEQEEK----MWEQEEKMCEQEEKMQEQEEKMRR 638
Query: 224 VKGNLTPLTGRNYRQLLERLQARQSRLD 251
+ + R RQ E++Q Q L+
Sbjct: 639 QEEKMWEQEVR-LRQQEEKMQEHQEHLE 665
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.9 bits (141), Expect = 7e-09
Identities = 78/332 (23%), Positives = 142/332 (42%), Gaps = 31/332 (9%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK--AKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPAD 102
K+K + Q+K R E + +E + K L K A + + EA + +
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSA 276
Query: 103 GLATEPESVFALDVLRQ-------RLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
L + E ++L Q R EKIQE + +EL E++ R++E+ +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHE 336
Query: 156 KRKR------KELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDE 209
+ ++ K R +EK R+ EE QE E E E ++ E++
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK 396
Query: 210 PASKAQRRKEK--RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAK 267
+ ++R+EK RQ K R + + R + + L+E+ E K +E+E K
Sbjct: 397 IREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Query: 268 MKWTNLLYKAEGVKIRDDERLLQEA----------LKRKEKRRAQRQRRW--EKRTAGVV 315
M+ + + KI+ E +QE LK++EK Q ++ W E++
Sbjct: 457 MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 316 EKMQQRQDRRRQNLRRKKAARAERRLLRARKK 347
EKMQ+++++ ++ + +K E RL + +K
Sbjct: 517 EKMQEQEEKMQR--QEEKMREQEVRLWQQEEK 546
Score = 56.2 bits (134), Expect = 4e-08
Identities = 64/286 (22%), Positives = 125/286 (43%), Gaps = 28/286 (9%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
++K + ++K +++EEK E + K ++ + +E+ + +
Sbjct: 296 EEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKI 355
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA 164
+ E + + R EKI+E + +E E++ R ++E+ ++K R+E +
Sbjct: 356 REQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKM 415
Query: 165 K---EKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKR 221
+ EK R+ EE QE E + E +VE E K Q ++EK
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEK----LREVEEKMQEEEEKMQEQEEKI 471
Query: 222 QRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVK 281
QR + + + +RQ E+L ++ ++ E E K E KM W + K
Sbjct: 472 QRQEEKIQEQEEKTWRQ--EKLLKQEEKIWE----QEEKMWRQEEKM-W------EQEEK 518
Query: 282 IRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQ 327
+++ E +Q +++EK R Q R W++ EKMQ+++ R ++
Sbjct: 519 MQEQEEKMQ---RQEEKMREQEVRLWQQE-----EKMQEQEVRLQE 556
Score = 43.5 bits (101), Expect = 3e-04
Identities = 79/358 (22%), Positives = 145/358 (40%), Gaps = 82/358 (22%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK---AKSLGEKSP-----AASGARRPEAAKEEAAWASSS 96
KK + + F+KR+EK E K + K P + +RPE + E
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDH 184
Query: 97 A---GNPADGLATEPESVFALDVLRQ------------RLHEKIQEARGQGSAKELSPAA 141
A G + L E ++ +L++ R L EK++ + S +L+
Sbjct: 185 AVRMGTYIEKLTKERDAP-SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKD 243
Query: 142 LEKRRRRKQ----------ERDRKKRKRKELRAKEKA-------------RKAEEATEAQ 178
L+++ R Q E DR ++ + + AK +A ++ E+ +
Sbjct: 244 LKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE 303
Query: 179 EVVEATPEGACTEP---REPPGLIFNKVE-VSEDEPASKAQRRKEKRQRVKGNLTPLTGR 234
E ++ E C + RE ++ + E + E E + Q K RQ K
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--------- 354
Query: 235 NYRQLLERLQARQSRL----DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
R+ E+++ ++ ++ +++R QDE K QE E +M W + KIR+ E Q
Sbjct: 355 -IREQEEKIREQEEKMWRQEEKIREQDE-KIQEQEEEM-W------RQEEKIREQEEKRQ 405
Query: 291 EALKRKEKR--------RAQRQRRW-EKRTAGVVEKMQQRQDRRRQNLRRKKAARAER 339
E + R+EK+ R Q + W ++ +E+M Q Q+ + + + K E+
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Score = 32.3 bits (72), Expect = 0.68
Identities = 61/285 (21%), Positives = 107/285 (37%), Gaps = 34/285 (11%)
Query: 26 QQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK--AAEHKAKSLGEKSPAASGARRP 83
Q+ + R + + E +KK ++ +K R++EE+ E K + L E R
Sbjct: 393 QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLRE 452
Query: 84 EAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALE 143
K + E E + + QR EKIQE + +E
Sbjct: 453 VEEK----------------MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE------- 489
Query: 144 KRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKV 203
+ KQE +++ K R +EK + EE + QE E + RE ++ +
Sbjct: 490 --KLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQE---EKMREQEVRLWQQE 544
Query: 204 EVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLD-ELRGQDEGKAQ 262
E +++ + Q +E+ ++ L G +RL L EL+ Q+ Q
Sbjct: 545 EKMQEQEV-RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRW 307
+ + + Y A ++ + L R K RA+R RW
Sbjct: 604 QQQDHYRGHLQQYVAAYQQLASGKEALPSCSSR--KLRAKRWLRW 646
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 58.9 bits (141), Expect = 7e-09
Identities = 78/332 (23%), Positives = 142/332 (42%), Gaps = 31/332 (9%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK--AKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPAD 102
K+K + Q+K R E + +E + K L K A + + EA + +
Sbjct: 217 KEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSA 276
Query: 103 GLATEPESVFALDVLRQ-------RLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRK 155
L + E ++L Q R EKIQE + +EL E++ R++E+ +
Sbjct: 277 KLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHE 336
Query: 156 KRKR------KELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDE 209
+ ++ K R +EK R+ EE QE E E E ++ E++
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEK 396
Query: 210 PASKAQRRKEK--RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAK 267
+ ++R+EK RQ K R + + R + + L+E+ E K +E+E K
Sbjct: 397 IREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Query: 268 MKWTNLLYKAEGVKIRDDERLLQEA----------LKRKEKRRAQRQRRW--EKRTAGVV 315
M+ + + KI+ E +QE LK++EK Q ++ W E++
Sbjct: 457 MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Query: 316 EKMQQRQDRRRQNLRRKKAARAERRLLRARKK 347
EKMQ+++++ ++ + +K E RL + +K
Sbjct: 517 EKMQEQEEKMQR--QEEKMREQEVRLWQQEEK 546
Score = 56.2 bits (134), Expect = 4e-08
Identities = 64/286 (22%), Positives = 125/286 (43%), Gaps = 28/286 (9%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
++K + ++K +++EEK E + K ++ + +E+ + +
Sbjct: 296 EEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKI 355
Query: 105 ATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRA 164
+ E + + R EKI+E + +E E++ R ++E+ ++K R+E +
Sbjct: 356 REQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKM 415
Query: 165 K---EKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKR 221
+ EK R+ EE QE E + E +VE E K Q ++EK
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEK----LREVEEKMQEEEEKMQEQEEKI 471
Query: 222 QRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVK 281
QR + + + +RQ E+L ++ ++ E E K E KM W + K
Sbjct: 472 QRQEEKIQEQEEKTWRQ--EKLLKQEEKIWE----QEEKMWRQEEKM-W------EQEEK 518
Query: 282 IRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQ 327
+++ E +Q +++EK R Q R W++ EKMQ+++ R ++
Sbjct: 519 MQEQEEKMQ---RQEEKMREQEVRLWQQE-----EKMQEQEVRLQE 556
Score = 44.7 bits (104), Expect = 1e-04
Identities = 79/358 (22%), Positives = 146/358 (40%), Gaps = 82/358 (22%)
Query: 45 KKKRKKTQKKFRKREEKAAEHK---AKSLGEKSP-----AASGARRPEAAKEEAAWASSS 96
KK + + F+KR+EK E K + K P + +RPE + E
Sbjct: 125 KKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDH 184
Query: 97 A---GNPADGLATEPESVFALDVLRQ------------RLHEKIQEARGQGSAKELSPAA 141
A G + L E +++ +L++ R L EK++ + S +L+
Sbjct: 185 AVRMGTYIEKLTKERDAL-SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKD 243
Query: 142 LEKRRRRKQ----------ERDRKKRKRKELRAKEKA-------------RKAEEATEAQ 178
L+++ R Q E DR ++ + + AK +A ++ E+ +
Sbjct: 244 LKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE 303
Query: 179 EVVEATPEGACTEP---REPPGLIFNKVE-VSEDEPASKAQRRKEKRQRVKGNLTPLTGR 234
E ++ E C + RE ++ + E + E E + Q K RQ K
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEK--------- 354
Query: 235 NYRQLLERLQARQSRL----DELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQ 290
R+ E+++ ++ ++ +++R QDE K QE E +M W + KIR+ E Q
Sbjct: 355 -IREQEEKIREQEEKMWRQEEKIREQDE-KIQEQEEEM-W------RQEEKIREQEEKRQ 405
Query: 291 EALKRKEKR--------RAQRQRRW-EKRTAGVVEKMQQRQDRRRQNLRRKKAARAER 339
E + R+EK+ R Q + W ++ +E+M Q Q+ + + + K E+
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Score = 32.3 bits (72), Expect = 0.68
Identities = 61/285 (21%), Positives = 107/285 (37%), Gaps = 34/285 (11%)
Query: 26 QQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEK--AAEHKAKSLGEKSPAASGARRP 83
Q+ + R + + E +KK ++ +K R++EE+ E K + L E R
Sbjct: 393 QEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLRE 452
Query: 84 EAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALE 143
K + E E + + QR EKIQE + +E
Sbjct: 453 VEEK----------------MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQE------- 489
Query: 144 KRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKV 203
+ KQE +++ K R +EK + EE + QE E + RE ++ +
Sbjct: 490 --KLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQE---EKMREQEVRLWQQE 544
Query: 204 EVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLD-ELRGQDEGKAQ 262
E +++ + Q +E+ ++ L G +RL L EL+ Q+ Q
Sbjct: 545 EKMQEQEV-RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603
Query: 263 ELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRW 307
+ + + Y A ++ + L R K RA+R RW
Sbjct: 604 QQQDHYRGHLQQYVAAYQQLASGKEALPSCSSR--KLRAKRWLRW 646
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 58.5 bits (140), Expect = 9e-09
Identities = 79/352 (22%), Positives = 159/352 (45%), Gaps = 36/352 (10%)
Query: 5 LAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAE 64
L+ + Y ++ + + Q + + +++ SE K+ ++K ++ ++ +
Sbjct: 205 LSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 264
Query: 65 HKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEK 124
+A LG++ + S A+ +E W + + E ++ + Q EK
Sbjct: 265 AEADHLGKELQSVS-AKLQAQVEENELWNRLNQ--------QQEEKMWRQEEKIQEWEEK 315
Query: 125 IQEARGQGSAKELSPAALEKRRRRKQ----ERDRKKRKRKEL--RAKEKARKAEEATEAQ 178
IQE + +E E++ RR++ E++ K R+++E+ +EK R+ EE +
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQ 238
E E E E + K+ E K + ++EKRQ + + + RQ
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQE-----KIREQEEKRQEEE----KIREQEKRQ 426
Query: 239 LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDE-RLLQEALKRKE 297
E RQ +++R Q+E K +E E KM W E KIR++E R QE + R+E
Sbjct: 427 EQEAKMWRQE--EKIREQEE-KIREQEKKM-WRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 298 KRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGR 349
++ +++ W ++ EKM +++++ R+ + +K R E ++ +K R
Sbjct: 483 EKIHEQEEIWRQK-----EKMHEQEEKIRK--QEEKVWRQEEKIREQEEKIR 527
Score = 58.2 bits (139), Expect = 1e-08
Identities = 73/342 (21%), Positives = 146/342 (42%), Gaps = 37/342 (10%)
Query: 25 EQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPE 84
E++ A + E ++K ++ +KK ++EEK E + EK R E
Sbjct: 423 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 482
Query: 85 AA--KEEAAWASSSAGNPADG-LATEPESVFALDVLRQRLHEKIQEA-----RGQGSAKE 136
++E W + + + + E V+ + + EKI+E R + +E
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542
Query: 137 LSPAALEKRRRRKQERDRKKRKRKEL-----RAKEKARKAEEATEAQEVVEATPEGACTE 191
E+ + +QE+ ++ KR+E R +EK R+ EE QE E E
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 192 PREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLD 251
E K+ E++ + ++ +E+ +++ R+ E Q ++ ++
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI------------REQEEMTQEQEEKM- 649
Query: 252 ELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE----ALKRKEKRRAQRQRRW 307
G+ E K E E KM+ + KIR+ E+ ++E +++E + Q ++ W
Sbjct: 650 ---GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 706
Query: 308 --EKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKK 347
E++ EKMQ+++++ R+ + +K E RL + +K
Sbjct: 707 EQEEKMCEQEEKMQEQEEKMRR--QEEKMWEQEVRLRQQEEK 746
Score = 56.2 bits (134), Expect = 4e-08
Identities = 64/317 (20%), Positives = 136/317 (42%), Gaps = 18/317 (5%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGL 104
++K ++ ++K R++EEK E + K ++ + +EE W + +
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR-QEEMMWEKEEKMRRQEEM 371
Query: 105 ATEPESVFAL-DVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKEL- 162
E E + + EKI+E + +E EKR+ ++ R+++KR+ +E
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 431
Query: 163 --RAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK 220
R +EK R+ EE QE E E K+ E + R+E+
Sbjct: 432 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ--------EKIREEEKRQEQEEMWRQEE 483
Query: 221 RQRVKGNLTPLTGRNYRQ--LLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAE 278
+ + + + + Q + + + + R +E + E K +E E KM + +
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Query: 279 GVKIRDDERL-LQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARA 337
R++E++ QE + +EKR+ Q + W R + + +++ R+ + +R ++ R
Sbjct: 544 EEMWREEEKMHEQEKIWEEEKRQEQEDKMW--RQEEKIREQEEKVWRQEEKIREQEEKRQ 601
Query: 338 ERRLLRARKKGRILPQD 354
E+ +++ +I Q+
Sbjct: 602 EQEEKMWKQEEKIREQE 618
Score = 53.1 bits (126), Expect = 4e-07
Identities = 69/283 (24%), Positives = 125/283 (44%), Gaps = 35/283 (12%)
Query: 45 KKKRKKTQKKFRKREEKA--AEHKAKSLGEKSPAASGA--RRPEAAKE-EAAWASSSAGN 99
K+K + ++K RK+EEK E K + EK R+ E +E E W +
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 100 PADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKR 159
+ + E + D + R EKI+E + +E + R+QE R++++
Sbjct: 555 EQEKIWEEEKRQEQEDKM-WRQEEKIREQEEKVWRQE--------EKIREQEEKRQEQEE 605
Query: 160 KELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKE 219
K + +EK R+ EE + QE E E E K+ E++ + ++ +E
Sbjct: 606 KMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 220 KRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEG 279
+ + + R ++ E+ + + + +++R Q+E QE E KM W +
Sbjct: 666 QEETM--------WRQEEKIREQEKKIREQEEKIREQEE-MMQEQEEKM-W------EQE 709
Query: 280 VKIRDDERLLQEALKRKEKRRAQRQRRWEK--RTAGVVEKMQQ 320
K+ + E +QE ++EK R Q ++ WE+ R EKMQ+
Sbjct: 710 EKMCEQEEKMQE---QEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 57.4 bits (137), Expect = 2e-08
Identities = 85/365 (23%), Positives = 150/365 (41%), Gaps = 66/365 (18%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEH---------KAKSLGE 72
SA +Q+A+T Q PP+ R+K K E +H ++K+
Sbjct: 426 SAGQQEAKT----DQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSS 481
Query: 73 KSPAASGAR----------------RPEAAKEEAAWASSSAGNPADGLATEPESVFALDV 116
PA+ R P +A + P L +P+ F
Sbjct: 482 PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTP---LRMDPKCSFV--- 535
Query: 117 LRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRK-ELRAKEKARKAEEAT 175
++ ++++ R + A++L RR+K E D+++R + +L+ +E+ RK
Sbjct: 536 --EKERQRLENLRRKEEAEQL--------RRQKVEEDKRRRLEEVKLKREERLRKV---L 582
Query: 176 EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRN 235
+A+E VE E + + I K E +++E A+ + +K+ K R
Sbjct: 583 QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERL--AEEKAKKKAAAKKMEEVEARRK 640
Query: 236 YRQLLERLQARQSRLDELRGQD---EGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEA 292
+ RL+ Q +E R Q+ + K +E E K AE R+ ER QE
Sbjct: 641 QEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ---REQERREQE- 696
Query: 293 LKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILP 352
+R+++RR Q +R E+R Q+RQ ++ R ++ +AER L K R+
Sbjct: 697 -RREQERREQERREQERRE-------QERQLAEQERRREQERLQAERELQEREKALRLQK 748
Query: 353 QDLER 357
+ L+R
Sbjct: 749 EQLQR 753
Score = 56.6 bits (135), Expect = 3e-08
Identities = 84/384 (21%), Positives = 147/384 (38%), Gaps = 56/384 (14%)
Query: 4 LLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAA 63
L K A + + +I HS E+ + GSE PP++ + E
Sbjct: 339 LAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGN 398
Query: 64 E-------HKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESV----- 111
A S PAAS P A ++EA + ADG P+S
Sbjct: 399 NSWPHNDTEIANSTPNPKPAASSPETPSAGQQEA------KTDQADGPREPPQSARRKRS 452
Query: 112 --FALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRR----------RKQ--------- 150
A+ L + H + +E + S SP K R R Q
Sbjct: 453 YKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAP 512
Query: 151 --------ERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNK 202
+R+ R + EK R+ E +E E E + +
Sbjct: 513 RSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRR---LEE 569
Query: 203 VEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQ-ARQSRLDELRGQDEG-- 259
V++ +E K + +E+ +++K + + Q+ E+ + A++ RL E + + +
Sbjct: 570 VKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA 629
Query: 260 -KAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRR--WEKRTAGVVE 316
K +E+EA+ K + ++ ++ER QE L++K++ +R R+ KR A E
Sbjct: 630 KKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689
Query: 317 KMQQRQDRRRQNLRRKKAARAERR 340
+ ++ Q+RR Q R ++ ERR
Sbjct: 690 QERREQERREQERREQERREQERR 713
Score = 53.1 bits (126), Expect = 4e-07
Identities = 54/233 (23%), Positives = 107/233 (45%), Gaps = 37/233 (15%)
Query: 45 KKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGARRPEAAKE----EAAWASSSAGNP 100
++K+K+ ++KF + +EK + K + L E+ A++ AAK+ EA
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEK-----AKKKAAAKKMEEVEARRKQEEEARR 647
Query: 101 ADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRK 160
L E E +R H+++ + + + + L AA KR ++E++R++++R+
Sbjct: 648 LRWLQQEEE---------ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 698
Query: 161 ELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK 220
E +E+ R+ +E E + + A E R + + E+ E E A + Q+ + +
Sbjct: 699 EQERREQERREQERREQERQL------AEQERRREQERLQAERELQEREKALRLQKEQLQ 752
Query: 221 RQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNL 273
R+ L + ++ +RL RQ L+ + E KA+E K N+
Sbjct: 753 RE--------LEEKKKKEEQQRLAERQ-----LQEEQEKKAKEAAGASKALNV 792
Score = 35.8 bits (81), Expect = 0.061
Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 22/159 (13%)
Query: 45 KKKRKKTQKKFRKR-------EEKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSA 97
+KK+++ Q++ RK E++ E + + E+ R E ++E A
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724
Query: 98 GNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKR 157
+ L E E L E+ + R Q KE LE++++ K+E+ R
Sbjct: 725 RREQERLQAERE-----------LQEREKALRLQ---KEQLQRELEEKKK-KEEQQRLAE 769
Query: 158 KRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPP 196
++ + ++KA++A A++A V ACT + P
Sbjct: 770 RQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTP 808
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 57.0 bits (136), Expect = 3e-08
Identities = 74/322 (22%), Positives = 128/322 (39%), Gaps = 35/322 (10%)
Query: 41 AGPPKKKRKKTQKKFRKREEKA-AEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGN 99
A P +KK KK +++ ++E+ A A ++ + PA+ AR + E + S + +
Sbjct: 409 ASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPS 468
Query: 100 PADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAALEKRRRRKQE-------- 151
P S L K RG + A+ + R RRK+E
Sbjct: 469 SPSTSWHRPASPCPSPGPGHTLPPKPPSPRG-------TTASPKGRVRRKEEAKESPSAA 521
Query: 152 --RDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPGLIFNKVEVSEDE 209
D+ + KR+ KE A A A +P A + +PP V
Sbjct: 522 GPEDKSQSKRRASNEKESAAPASPAPSPAP----SPTPAPPQKEQPPAETPTDAAVLTSP 577
Query: 210 PASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQA---RQSRLDELRGQDEGKAQ-ELE 265
PA K P+ G R+ RL A RQ+R R + E + Q E +
Sbjct: 578 PAPAPPVTPSK---------PMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD 628
Query: 266 AKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRR 325
+M+ L +AE R+ E +E + +EK +A+++ + + + + R++
Sbjct: 629 KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAE 688
Query: 326 RQNLRRKKAARAERRLLRARKK 347
RQ L R+K + + + + R+K
Sbjct: 689 RQRLEREKHFQQQEQERQERRK 710
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/262 (22%), Positives = 105/262 (40%), Gaps = 27/262 (10%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
++P+ + R + + AGP K + K ++ +E AA SP + +
Sbjct: 502 ASPKGRVRRKEEAKESPSAAGPEDKSQSK--RRASNEKESAAPASPAPSPAPSPTPAPPQ 559
Query: 82 RPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAA 141
+ + E A+ PA P A R+ + E R Q A
Sbjct: 560 KEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ---------A 610
Query: 142 LEKRRRRKQER----DRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPREPPG 197
E+R R +QER +R KR R+E A+E +AE EA+ E +E
Sbjct: 611 REQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
Query: 198 LIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDELRGQD 257
+ + E +E +A+R++ +R+ ++++Q + Q R+ RL+E+ +
Sbjct: 671 RLQKQKEEAEARSREEAERQRLERE-----------KHFQQQEQERQERRKRLEEIMKRT 719
Query: 258 EGKAQELEAKMKWTNLLYKAEG 279
K++ E K K + A G
Sbjct: 720 R-KSEVSETKQKQDSKEANANG 740
Score = 46.2 bits (108), Expect = 5e-05
Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 25/198 (12%)
Query: 24 PEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKA---KSLGEKSPAASGA 80
P ++ AG T E +KR++ +++ R+REE+ +A K + E+ A
Sbjct: 583 PVTPSKPMAGTTDREEATRLLAEKRRQAREQ-REREEQERRLQAERDKRMREEQLAREAE 641
Query: 81 RRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPA 140
R E E A A E E RL ++ +EA + S +E
Sbjct: 642 ARAEREAEARRREEQEAREKAQAEQEEQE----------RLQKQKEEAEAR-SREEAERQ 690
Query: 141 ALEKRR---RRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEP----- 192
LE+ + +++QER ++++ +E+ + + + E + Q+ EA G+ EP
Sbjct: 691 RLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVE 750
Query: 193 REPPGLIFNKVEVSEDEP 210
PGL K V ++EP
Sbjct: 751 ARSPGL--QKEAVQKEEP 766
Score = 35.8 bits (81), Expect = 0.061
Identities = 34/147 (23%), Positives = 65/147 (44%), Gaps = 13/147 (8%)
Query: 23 APEQQARTRAGK--TQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGA 80
+P +A++R G A PP++ + + + + + K GE+ A
Sbjct: 86 SPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAK-E 144
Query: 81 RRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPA 140
RR E AK AA A L E ++ + Q +++E R + + A
Sbjct: 145 RREERAKYLAA-------KKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRR---A 194
Query: 141 ALEKRRRRKQERDRKKRKRKELRAKEK 167
ALE+R+R+K E+++++ + R+ +K
Sbjct: 195 ALEERQRQKLEKNKERYEAAIQRSVKK 221
Score = 29.6 bits (65), Expect = 4.4
Identities = 41/170 (24%), Positives = 69/170 (40%), Gaps = 26/170 (15%)
Query: 60 EKAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQ 119
+ A K L +SP+ RP +EE+ + + + P P ++ D
Sbjct: 56 KNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPT------PPAMGPRDARPP 109
Query: 120 RLHEKIQEARGQGSAKELSPAALEKRRRRKQ-ERDRKKRKRKELRAKEKARKAEEATEAQ 178
R + ++ +A S + K+ +K ER + ++R+E RAK A K E +
Sbjct: 110 R-----RSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKE 164
Query: 179 EVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRK---EKRQRVK 225
E +A E E R +E KA++R+ E+RQR K
Sbjct: 165 EKAKALREKQLQERRR-----------RLEEQRLKAEQRRAALEERQRQK 203
Score = 29.6 bits (65), Expect = 4.4
Identities = 17/58 (29%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 290 QEALKRKEKRRAQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKK 347
++A +EK+ +R+RR E++ ++ ++R+RQ L + K R E + R+ KK
Sbjct: 165 EKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK-ERYEAAIQRSVKK 221
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 56.2 bits (134), Expect = 4e-08
Identities = 74/314 (23%), Positives = 131/314 (41%), Gaps = 69/314 (21%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
S ++ R+ KTQ S KK+ K++ +K K+E K + K + EK+ + +
Sbjct: 464 SGDKKNTSDRSSKTQASV-----KKEEKRSSEKSEKKESKDTK-KIEGKDEKNDNGASGQ 517
Query: 82 RPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAA 141
E+ K+ S+ +P + + R+ +EKI G +KE A+
Sbjct: 518 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKI-----HGRSKEKERAS 572
Query: 142 LEKRR----RRKQ----ERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR 193
L+K+R RRK+ E+ +++R R+ L E+ R+A E +E+ E
Sbjct: 573 LDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAE----------- 621
Query: 194 EPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDEL 253
+RR+ +R R+ R+ ERLQ + RL+
Sbjct: 622 --------------------RERRERERIRI---------IREREERERLQRERERLEIE 652
Query: 254 RGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE--ALKRKEKRRAQRQRRWEKRT 311
R + E + E E + E ++I + R E A +R+E RR Q+Q R+E+
Sbjct: 653 RQKLERERMERER--------LERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEK 704
Query: 312 AGVVEKMQQRQDRR 325
+++ + RR
Sbjct: 705 RNSLKRPRDVDHRR 718
Score = 42.7 bits (99), Expect = 5e-04
Identities = 81/362 (22%), Positives = 139/362 (38%), Gaps = 46/362 (12%)
Query: 17 KICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHK------AKSL 70
K S + + + ++ K S T+G K KAA+ K K L
Sbjct: 334 KSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVL 393
Query: 71 GEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEK---IQE 127
K + AR P A SSS TE A + R LH + +++
Sbjct: 394 SAK--VVTNARSPGAKCYGIVTMSSS---------TEVSRCIA-HLHRTELHGQLISVEK 441
Query: 128 ARGQGSAKELSPAALEKRRRR-----KQERDRKKR-----KRKELRAKEKARKAE--EAT 175
+G S KE+ EK R K DR + K++E R+ EK+ K E +
Sbjct: 442 VKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTK 501
Query: 176 EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK----RQRVKGNLTPL 231
+ + E GA + E K +S P + K R +G +
Sbjct: 502 KIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKI 561
Query: 232 TGRNY---RQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERL 288
GR+ R L++ + + R E+ ++ K Q L + L +A +++R +
Sbjct: 562 HGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRA--MELRRRREI 619
Query: 289 LQEALKRKEKRRAQRQRRWEKRTAGVVEKMQ-QRQDRRRQNLRRKKAARAERRLLRARKK 347
+ + +E+ R R+R +R E+++ +RQ R+ + R+ R ER +R ++
Sbjct: 620 AERERRERERIRIIREREERERLQRERERLEIERQKLERERMERE---RLERERIRIEQE 676
Query: 348 GR 349
R
Sbjct: 677 RR 678
Score = 31.2 bits (69), Expect = 1.5
Identities = 65/299 (21%), Positives = 106/299 (35%), Gaps = 18/299 (6%)
Query: 21 HSAPEQQARTRA--GKTQGSETAGPPKKKRKKTQKK----FRKREEKAAEHKAKSLGEKS 74
H P ++ R G+++ E A KK+ K ++K F K +E+
Sbjct: 549 HCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLR 608
Query: 75 PAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSA 134
A RR E A+ E + E E L QR E+++ R +
Sbjct: 609 RAMELRRRREIAERERRERERIR------IIREREERERL----QRERERLEIERQKLER 658
Query: 135 KELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPRE 194
+ + LE+ R R ++ RK+ +R +E R+ ++ QE + + R
Sbjct: 659 ERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR 718
Query: 195 PPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQ-SRLDEL 253
++S D A RQ+ + N R +Q+ R D
Sbjct: 719 DDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRF 778
Query: 254 RGQDEGKAQELEAKMKWTNL-LYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRT 311
GQ EGK A+ + + Y R +E R+ RR R R E+RT
Sbjct: 779 VGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRT 837
Score = 28.5 bits (62), Expect = 9.8
Identities = 33/161 (20%), Positives = 62/161 (38%), Gaps = 15/161 (9%)
Query: 126 QEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATP 185
QEA Q EL K E + + KEL + E+ ++A E EA+ + +
Sbjct: 112 QEAHEQDGNDEL------KDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEK 165
Query: 186 EGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQA 245
E ++ E + ED+ AQ +E+ +G+L + ++
Sbjct: 166 EDIESQEIE--------AQEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEEMEAHTTV 217
Query: 246 RQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDE 286
+++ D + + + + +LL + VKI D E
Sbjct: 218 KEAEDDNISVTIQAE-DAITLDFDGDDLLETGKNVKITDSE 257
>gi|63176611 modulator of estrogen induced transcription isoform a
[Homo sapiens]
Length = 1034
Score = 56.2 bits (134), Expect = 4e-08
Identities = 74/314 (23%), Positives = 131/314 (41%), Gaps = 69/314 (21%)
Query: 22 SAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHKAKSLGEKSPAASGAR 81
S ++ R+ KTQ S KK+ K++ +K K+E K + K + EK+ + +
Sbjct: 482 SGDKKNTSDRSSKTQASV-----KKEEKRSSEKSEKKESKDTK-KIEGKDEKNDNGASGQ 535
Query: 82 RPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSAKELSPAA 141
E+ K+ S+ +P + + R+ +EKI G +KE A+
Sbjct: 536 TSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKI-----HGRSKEKERAS 590
Query: 142 LEKRR----RRKQ----ERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPR 193
L+K+R RRK+ E+ +++R R+ L E+ R+A E +E+ E
Sbjct: 591 LDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAE----------- 639
Query: 194 EPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQSRLDEL 253
+RR+ +R R+ R+ ERLQ + RL+
Sbjct: 640 --------------------RERRERERIRI---------IREREERERLQRERERLEIE 670
Query: 254 RGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQE--ALKRKEKRRAQRQRRWEKRT 311
R + E + E E + E ++I + R E A +R+E RR Q+Q R+E+
Sbjct: 671 RQKLERERMERER--------LERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEK 722
Query: 312 AGVVEKMQQRQDRR 325
+++ + RR
Sbjct: 723 RNSLKRPRDVDHRR 736
Score = 42.7 bits (99), Expect = 5e-04
Identities = 81/362 (22%), Positives = 139/362 (38%), Gaps = 46/362 (12%)
Query: 17 KICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREEKAAEHK------AKSL 70
K S + + + ++ K S T+G K KAA+ K K L
Sbjct: 352 KSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVL 411
Query: 71 GEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEK---IQE 127
K + AR P A SSS TE A + R LH + +++
Sbjct: 412 SAK--VVTNARSPGAKCYGIVTMSSS---------TEVSRCIA-HLHRTELHGQLISVEK 459
Query: 128 ARGQGSAKELSPAALEKRRRR-----KQERDRKKR-----KRKELRAKEKARKAE--EAT 175
+G S KE+ EK R K DR + K++E R+ EK+ K E +
Sbjct: 460 VKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTK 519
Query: 176 EAQEVVEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEK----RQRVKGNLTPL 231
+ + E GA + E K +S P + K R +G +
Sbjct: 520 KIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKI 579
Query: 232 TGRNY---RQLLERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERL 288
GR+ R L++ + + R E+ ++ K Q L + L +A +++R +
Sbjct: 580 HGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRA--MELRRRREI 637
Query: 289 LQEALKRKEKRRAQRQRRWEKRTAGVVEKMQ-QRQDRRRQNLRRKKAARAERRLLRARKK 347
+ + +E+ R R+R +R E+++ +RQ R+ + R+ R ER +R ++
Sbjct: 638 AERERRERERIRIIREREERERLQRERERLEIERQKLERERMERE---RLERERIRIEQE 694
Query: 348 GR 349
R
Sbjct: 695 RR 696
Score = 31.2 bits (69), Expect = 1.5
Identities = 65/299 (21%), Positives = 106/299 (35%), Gaps = 18/299 (6%)
Query: 21 HSAPEQQARTRA--GKTQGSETAGPPKKKRKKTQKK----FRKREEKAAEHKAKSLGEKS 74
H P ++ R G+++ E A KK+ K ++K F K +E+
Sbjct: 567 HCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLR 626
Query: 75 PAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQRLHEKIQEARGQGSA 134
A RR E A+ E + E E L QR E+++ R +
Sbjct: 627 RAMELRRRREIAERERRERERIR------IIREREERERL----QRERERLEIERQKLER 676
Query: 135 KELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEVVEATPEGACTEPRE 194
+ + LE+ R R ++ RK+ +R +E R+ ++ QE + + R
Sbjct: 677 ERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRR 736
Query: 195 PPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLLERLQARQ-SRLDEL 253
++S D A RQ+ + N R +Q+ R D
Sbjct: 737 DDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRF 796
Query: 254 RGQDEGKAQELEAKMKWTNL-LYKAEGVKIRDDERLLQEALKRKEKRRAQRQRRWEKRT 311
GQ EGK A+ + + Y R +E R+ RR R R E+RT
Sbjct: 797 VGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRT 855
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,119,302
Number of Sequences: 37866
Number of extensions: 706849
Number of successful extensions: 15879
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 412
Number of HSP's successfully gapped in prelim test: 881
Number of HSP's that attempted gapping in prelim test: 6704
Number of HSP's gapped (non-prelim): 5117
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.