BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [Homo sapiens] (438 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 878 0.0 gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 878 0.0 gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 871 0.0 gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 270 2e-72 gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 142 8e-34 gi|219689123 pleckstrin homology domain containing, family A mem... 71 2e-12 gi|19923493 pleckstrin homology domain containing, family A memb... 71 2e-12 gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 67 3e-11 gi|238859653 pleckstrin homology domain containing family A memb... 63 6e-10 gi|238859651 pleckstrin homology domain containing family A memb... 63 6e-10 gi|239047795 pleckstrin homology domain containing, family A mem... 54 2e-07 gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [H... 54 2e-07 gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [H... 54 2e-07 gi|154354979 myosin X [Homo sapiens] 53 6e-07 gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] 50 4e-06 gi|126091130 Gab3 protein isoform 1 [Homo sapiens] 49 1e-05 gi|18079323 Gab3 protein isoform 2 [Homo sapiens] 48 2e-05 gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 45 1e-04 gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 45 2e-04 gi|20149626 pleckstrin homology domain containing, family O memb... 44 4e-04 gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 43 5e-04 gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 43 5e-04 gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 43 5e-04 gi|46195763 metastasis suppressor 1-like [Homo sapiens] 43 5e-04 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 43 5e-04 gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 43 6e-04 gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 42 0.001 gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap... 42 0.001 gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sap... 42 0.001 gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sap... 42 0.001 >gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [Homo sapiens] Length = 438 Score = 878 bits (2268), Expect = 0.0 Identities = 438/438 (100%), Positives = 438/438 (100%) Query: 1 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS Sbjct: 1 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60 Query: 61 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY Sbjct: 61 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120 Query: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT Sbjct: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180 Query: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT Sbjct: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240 Query: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI Sbjct: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300 Query: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI Sbjct: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360 Query: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD Sbjct: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420 Query: 421 TPQELKKSPSSPSVENSI 438 TPQELKKSPSSPSVENSI Sbjct: 421 TPQELKKSPSSPSVENSI 438 >gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [Homo sapiens] Length = 438 Score = 878 bits (2268), Expect = 0.0 Identities = 438/438 (100%), Positives = 438/438 (100%) Query: 1 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS Sbjct: 1 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60 Query: 61 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY Sbjct: 61 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120 Query: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT Sbjct: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180 Query: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT Sbjct: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240 Query: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI Sbjct: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300 Query: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI Sbjct: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360 Query: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD Sbjct: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420 Query: 421 TPQELKKSPSSPSVENSI 438 TPQELKKSPSSPSVENSI Sbjct: 421 TPQELKKSPSSPSVENSI 438 >gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo sapiens] Length = 437 Score = 871 bits (2251), Expect = 0.0 Identities = 437/438 (99%), Positives = 437/438 (99%), Gaps = 1/438 (0%) Query: 1 MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60 MTSYMAIDGSAL VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS Sbjct: 1 MTSYMAIDGSAL-VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 59 Query: 61 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY Sbjct: 60 NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 119 Query: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT Sbjct: 120 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 179 Query: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT Sbjct: 180 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 239 Query: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI Sbjct: 240 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 299 Query: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI Sbjct: 300 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 359 Query: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD Sbjct: 360 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 419 Query: 421 TPQELKKSPSSPSVENSI 438 TPQELKKSPSSPSVENSI Sbjct: 420 TPQELKKSPSSPSVENSI 437 >gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo sapiens] Length = 1034 Score = 270 bits (690), Expect = 2e-72 Identities = 164/463 (35%), Positives = 256/463 (55%), Gaps = 68/463 (14%) Query: 13 QVPLRQKPRRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILK 71 Q L+ K ++K +G + S+RRISCKDLG DC+GWL+KKK+ S+ S KWKK+W +LK Sbjct: 540 QSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLK 599 Query: 72 GSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNV 131 +SLYWY N+ EKA+GF++LP+F ++RASEC+KK+AFK HP+IK+FYFAAE++ +MN Sbjct: 600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR 659 Query: 132 WLNK---LGSAVIHQESTTKDEECYSESEQEDPEIAA----ETPPPPH------------ 172 WLN+ L + +E ++++ +SES++E+ + + ++PPPP+ Sbjct: 660 WLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCA 719 Query: 173 ---------------ASQTQSLTAQ-----QASSSSPSLSGTSYSFSSLENTVKTPSSFP 212 SQ+QS + SS+ + T+ S ++ ++TP + Sbjct: 720 SPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSS 779 Query: 213 SSLSKERQSLPDTVNSLSAA--EDEGQPITFAVQV------HSPVPSEAGIHKALEN--- 261 + L D+V S SAA + + T Q + P P + N Sbjct: 780 GLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNG 839 Query: 262 ----SFVTSESGFLNSLSSDDTSSLSSNHDHLTVPD------------KPAGSKIMDKEE 305 SF N + S D + P+ + AG I +K E Sbjct: 840 GKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSE 899 Query: 306 TKVSE-DDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLN 364 ++ + D ++ LY++LEQASLSPLG+ R STK E + SF+KRC +P +NEKLH++R L Sbjct: 900 SREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILK 959 Query: 365 STLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQ 407 STLK +E ++A+I+++LD+P LT++++++WK M L DI Q Sbjct: 960 STLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQ 1002 >gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo sapiens] Length = 713 Score = 142 bits (357), Expect = 8e-34 Identities = 66/192 (34%), Positives = 115/192 (59%), Gaps = 8/192 (4%) Query: 21 RRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYS 79 R+K++G T +SRRR+SC++LG DC GWL +K G F+ +W++ W +LKG +LYWY Sbjct: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433 Query: 80 NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 139 EKA+G +N+ ++++E + KKK+ F+++H K F FAA+ + ++++W+ L + Sbjct: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493 Query: 140 VIHQES-----TTKDEECYSESEQEDP--EIAAETPPPPHASQTQSLTAQQASSSSPSLS 192 + +S ++E+CYSE+E EDP E + + P A L + +++P+ Sbjct: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQR 553 Query: 193 GTSYSFSSLENT 204 SF SL ++ Sbjct: 554 SPRTSFGSLTDS 565 Score = 88.6 bits (218), Expect = 1e-17 Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 8/133 (6%) Query: 309 SEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLK 368 S ++ +E + + L Q +S LG +P T+++ R SF++R ++P +NE++H++R L STLK Sbjct: 565 SSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLK 624 Query: 369 CKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQD------IYQQQRASP--APDDTDD 420 K +L ++ ++L DP+LT K+R+WK N L + + Q + +S D T+ Sbjct: 625 AKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQ 684 Query: 421 TPQELKKSPSSPS 433 +P L P S Sbjct: 685 SPHSLPSDPEEHS 697 >gi|219689123 pleckstrin homology domain containing, family A member 5 isoform 2 [Homo sapiens] Length = 1105 Score = 70.9 bits (172), Expect = 2e-12 Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%) Query: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102 +GWLYK+ G L WKK W +L L++Y ++ E G + LP F + + Sbjct: 65 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 121 Query: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156 +K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+ Sbjct: 122 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 176 >gi|19923493 pleckstrin homology domain containing, family A member 5 isoform 1 [Homo sapiens] Length = 1116 Score = 70.9 bits (172), Expect = 2e-12 Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%) Query: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 102 +GWLYK+ G L WKK W +L L++Y ++ E G + LP F + + Sbjct: 173 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 229 Query: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 156 +K+AFK +HP ++T+YF + +EM +W+ L +A++ E + ++ SE+ Sbjct: 230 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 284 >gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo sapiens] Length = 1048 Score = 67.0 bits (162), Expect = 3e-11 Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 6/132 (4%) Query: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDF---TVERASEC 103 GWL+K+ G +W K W +L L++Y ++ E G + L F V+ + Sbjct: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120 Query: 104 KKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEI 163 +KH FK H ++T++F+AE+ +E W+ +G A Q + + + Sbjct: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180 Query: 164 AAETPPPPHASQ 175 + PP H Q Sbjct: 181 SENVPPSKHHQQ 192 >gi|238859653 pleckstrin homology domain containing family A member 4 isoform 2 [Homo sapiens] Length = 583 Score = 62.8 bits (151), Expect = 6e-10 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%) Query: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102 +GWL+K+ G L WK+ W +L G L++Y + E G V LP + + + Sbjct: 58 RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114 Query: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162 ++ F HP ++T+ AA+ ++++ WL LG A + + + Y + Sbjct: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168 Query: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221 E P P S + S SP ++ S +P++ S L R Sbjct: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228 Query: 222 LPDTVNSLS 230 PD LS Sbjct: 229 SPDLFTPLS 237 >gi|238859651 pleckstrin homology domain containing family A member 4 isoform 1 [Homo sapiens] Length = 779 Score = 62.8 bits (151), Expect = 6e-10 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%) Query: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 102 +GWL+K+ G L WK+ W +L G L++Y + E G V LP + + + Sbjct: 58 RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114 Query: 103 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 162 ++ F HP ++T+ AA+ ++++ WL LG A + + + Y + Sbjct: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168 Query: 163 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 221 E P P S + S SP ++ S +P++ S L R Sbjct: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228 Query: 222 LPDTVNSLS 230 PD LS Sbjct: 229 SPDLFTPLS 237 >gi|239047795 pleckstrin homology domain containing, family A member 7 [Homo sapiens] Length = 1121 Score = 54.3 bits (129), Expect = 2e-07 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 27/130 (20%) Query: 46 QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERAS---E 102 +GWL+K+ G L WK+ W +L L++Y + E G + LP + + + Sbjct: 168 RGWLHKQDSSGMRL---WKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDR 224 Query: 103 CKKKHAFKISH-------------------PQIKTFYFAAENVQEMNVWLNKLGSA--VI 141 +K++FK H ++T+YF+A+ ++MN W+ + A V+ Sbjct: 225 ISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVL 284 Query: 142 HQESTTKDEE 151 + S +D E Sbjct: 285 SRSSLKRDME 294 >gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [Homo sapiens] Length = 358 Score = 54.3 bits (129), Expect = 2e-07 Identities = 30/127 (23%), Positives = 64/127 (50%), Gaps = 7/127 (5%) Query: 38 KDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTV 97 ++L + QG+L KK + SF ++W+K W ++ Y+Y+N+ +++ G + + V Sbjct: 103 QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGV 162 Query: 98 ERA----SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECY 153 A + KK+ F+++ +++ F A + E W++++ + S T Y Sbjct: 163 RMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIP---Y 219 Query: 154 SESEQED 160 E E+E+ Sbjct: 220 EEDEEEE 226 >gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [Homo sapiens] Length = 359 Score = 54.3 bits (129), Expect = 2e-07 Identities = 30/127 (23%), Positives = 64/127 (50%), Gaps = 7/127 (5%) Query: 38 KDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTV 97 ++L + QG+L KK + SF ++W+K W ++ Y+Y+N+ +++ G + + V Sbjct: 103 QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGV 162 Query: 98 ERA----SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECY 153 A + KK+ F+++ +++ F A + E W++++ + S T Y Sbjct: 163 RMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIP---Y 219 Query: 154 SESEQED 160 E E+E+ Sbjct: 220 EEDEEEE 226 >gi|154354979 myosin X [Homo sapiens] Length = 2058 Score = 52.8 bits (125), Expect = 6e-07 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 7/123 (5%) Query: 46 QGWLYKKKEKGSFLSNK-WKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECK 104 QGWL+KK S LS + WKK W +L+ S L ++ N EK G V + E Sbjct: 1216 QGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRT-AKEIIDNTT 1274 Query: 105 KKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIA 164 K++ I +TF+ AE+ ++ + W + L +H + + +E + EQ +P+ A Sbjct: 1275 KENGIDIIMAD-RTFHLIAESPEDASQWFSVLSQ--VHASTDQEIQEMH--DEQANPQNA 1329 Query: 165 AET 167 T Sbjct: 1330 VGT 1332 Score = 32.0 bits (71), Expect = 1.1 Identities = 32/152 (21%), Positives = 67/152 (44%), Gaps = 10/152 (6%) Query: 59 LSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLP---DFTVERASECKKKHAFKISHPQ 115 L N WK+ W +LK + W+ ++ G+++ T+ R + K+ + Q Sbjct: 1188 LMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLR----Q 1243 Query: 116 IKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQ 175 K YF ++ +++ + ++ +A ++TTK+ + AE+ P ASQ Sbjct: 1244 SKLMYFENDSEEKLKGTV-EVRTAKEIIDNTTKENGIDIIMADRTFHLIAES--PEDASQ 1300 Query: 176 TQSLTAQQASSSSPSLSGTSYSFSSLENTVKT 207 S+ +Q +S+ + ++ +N V T Sbjct: 1301 WFSVLSQVHASTDQEIQEMHDEQANPQNAVGT 1332 >gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] Length = 359 Score = 50.1 bits (118), Expect = 4e-06 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 4/130 (3%) Query: 35 ISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPD 94 I+ +DL G+L K+++ SFL +W+K W L + Y+Y + ++ G + Sbjct: 109 IAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168 Query: 95 FTVER----ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 150 ++V + KK F+IS P + + F A + ++ W+ +L + ES E Sbjct: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPE 228 Query: 151 ECYSESEQED 160 + E D Sbjct: 229 DYDERGELYD 238 >gi|126091130 Gab3 protein isoform 1 [Homo sapiens] Length = 587 Score = 48.5 bits (114), Expect = 1e-05 Identities = 60/249 (24%), Positives = 93/249 (37%), Gaps = 36/249 (14%) Query: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93 G A C GWL K + W+K W +L+ L +Y N+ + K ++L Sbjct: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63 Query: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146 + V + E + F I +TFY A+ QEM VW +H S Sbjct: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVW--------VHSISQ 114 Query: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205 + + + E + TP S S LTA ASSS P + + ++ E Sbjct: 115 VCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 174 Query: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253 ++ F P L SLP +S S ++ + +F V P+PS Sbjct: 175 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 234 Query: 254 GIHKALENS 262 +H + S Sbjct: 235 LVHPSCHGS 243 >gi|18079323 Gab3 protein isoform 2 [Homo sapiens] Length = 586 Score = 47.8 bits (112), Expect = 2e-05 Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 37/249 (14%) Query: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93 G A C GWL K + W+K W +L+ L +Y N+ + K ++L Sbjct: 4 GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63 Query: 94 DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 146 + V + E + F I +TFY A+ QEM VW++ + Sbjct: 64 ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVWVHSISQVC------ 116 Query: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 205 + E + E + TP S S LTA ASSS P + + ++ E Sbjct: 117 ---NLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 173 Query: 206 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 253 ++ F P L SLP +S S ++ + +F V P+PS Sbjct: 174 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 233 Query: 254 GIHKALENS 262 +H + S Sbjct: 234 LVHPSCHGS 242 >gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sapiens] Length = 676 Score = 45.1 bits (105), Expect = 1e-04 Identities = 61/269 (22%), Positives = 101/269 (37%), Gaps = 28/269 (10%) Query: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 93 G C GWL K + WKK W IL+ L +Y N ++K +NL Sbjct: 5 GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL- 63 Query: 94 DFTVE-------RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQES 145 +F + E + F I + +TFY AE ++MN W+ + +Q Sbjct: 64 NFCEQVDAGLTFNKKELQDSFVFDIKTSE-RTFYLVAETEEDMNKWVQSICQICGFNQAE 122 Query: 146 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 205 + D S P +P +S L +++S+ S S T ++F + Sbjct: 123 ESTDSLRNVSSAGHGPR---SSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNH 179 Query: 206 KTPSSFPSSLSKERQSLPDTV-----NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 260 P + +S +E L + N+ SA+ +G +F ++ + V A + Sbjct: 180 MQP-TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238 Query: 261 NSFVTSESGF--LNSLSSDDTSSLSSNHD 287 N GF L S +T S +D Sbjct: 239 NGISGQVHGFYSLPKPSRHNTEFRDSTYD 267 >gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] Length = 846 Score = 44.7 bits (104), Expect = 2e-04 Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 20/159 (12%) Query: 51 KKKEKGSFLSNKWKKFWVILKGSSLY----------WY-SNQMAEKADGFVNLPDFTVER 99 K E G + W W +L+GSSL W+ SNQ K + V+L T+E Sbjct: 474 KIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQ--SKPEFTVDLKGATIEM 531 Query: 100 ASECK--KKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKD--EECYSE 155 AS+ K KK+ F++ Q ++N +N W L S + +Q T + EE + Sbjct: 532 ASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD 591 Query: 156 S---EQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSL 191 S E+ D E + P + + S+ + + + +L Sbjct: 592 SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNL 630 >gi|20149626 pleckstrin homology domain containing, family O member 1 [Homo sapiens] Length = 409 Score = 43.5 bits (101), Expect = 4e-04 Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 19/189 (10%) Query: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKAD--GFVNLPDFTV-----ER 99 GW+ K KG F WK +V+LKG LY ++ ++ + +L D+ + Sbjct: 26 GWVRKFCGKGIF-REIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKS 84 Query: 100 ASECKKKHA-FKISHPQ-----IKTFYFAAENVQEMNVWLNKLGSAVIHQ-----ESTTK 148 S KK H+ F ++H + F A + +E W+N L SA+ + T Sbjct: 85 KSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTV 144 Query: 149 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTP 208 +E+ Y D + PP ++ + S +L S E Sbjct: 145 EEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCA 204 Query: 209 SSFPSSLSK 217 SF L K Sbjct: 205 ESFRVDLDK 213 >gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sapiens] Length = 699 Score = 43.1 bits (100), Expect = 5e-04 Identities = 58/233 (24%), Positives = 88/233 (37%), Gaps = 43/233 (18%) Query: 144 ESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLEN 203 +S++ +EE S E++ ++ A T P A SL A+QA S S S S SS E Sbjct: 422 DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEE 481 Query: 204 TVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSF 263 KT S SA + + Q + P ++ G Sbjct: 482 EEKT--------------------SKSAVKKKPQKVAGGAAPSKPASAKKG--------- 512 Query: 264 VTSESGFLNSLSSDDTS-----SLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLY 318 +ES NS SSDD+S L K G+ + + K +++ E E+ Sbjct: 513 -KAESS--NSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE 569 Query: 319 KSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKE 371 K +S G S KK + K + P K K++T N+ K K+ Sbjct: 570 KKKAAVVVSKSG----SLKKRKQNEAAKEAETP--QAKKIKLQTPNTFPKRKK 616 Score = 38.9 bits (89), Expect = 0.009 Identities = 63/290 (21%), Positives = 109/290 (37%), Gaps = 39/290 (13%) Query: 80 NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 139 NQ++E A+ F +A+ ++ A S I +F+ + V E + N + Sbjct: 25 NQLSEVANKFA--------KATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAK 76 Query: 140 VIHQESTTKDEECYSESEQE---DPEIAAETPP-----PPHASQTQSLTAQQASSSSPSL 191 +++++ D E SE E+E P A P PP + ++ + + SS Sbjct: 77 KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136 Query: 192 SGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEG--------QPITFAV 243 ++ VK + + K+ +S +S S++EDE P+T Sbjct: 137 DEEDQKKQPVQKGVKPQAKAAKAPPKKAKS--SDSDSDSSSEDEPPKNQKPKITPVTVKA 194 Query: 244 QVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDT-SSLSSNHDHLTVPDKPAGSKIMD 302 Q +P K +S S +S SSDD+ ++ TVP K +K Sbjct: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254 Query: 303 K------------EETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKEL 340 K E++ E++E +K K+ S P KK L Sbjct: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304 Score = 35.4 bits (80), Expect = 0.10 Identities = 53/230 (23%), Positives = 88/230 (38%), Gaps = 35/230 (15%) Query: 143 QESTTKDEECYSESEQEDPE----------IAAET--PPPPHASQTQSLTAQQASSSSPS 190 +++ + D + S SE E P+ + A+T PP P + + + ASSSS S Sbjct: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221 Query: 191 LSGTSYSFSSLENTVKTP------------SSFPSSLSKERQSLPDTVNSLSAAEDEGQP 238 S +S S E TP + ++ + R+S +S E++ +P Sbjct: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281 Query: 239 ITFAVQVHS--PVPSEAGIHKAL----ENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVP 292 + +S P PS K+L V + +S S D S SS+ + P Sbjct: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD-SSSEEEKKPP 340 Query: 293 DKPAGSKIMDK----EETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKK 338 K SK K ++ S D + ++A P G + S+ K Sbjct: 341 TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNK 390 Score = 34.3 bits (77), Expect = 0.23 Identities = 52/230 (22%), Positives = 84/230 (36%), Gaps = 42/230 (18%) Query: 144 ESTTKDEECYSESEQEDPEIA----AETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFS 199 E ++ + + SE E++ P A A T PPP +S + S SS S Sbjct: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAG 382 Query: 200 SLEN-------TVKTPSSFPSSLSKE-----RQSLPDTVNSLSAAED----EGQPITFAV 243 + +N T K+P+ P++ K+ ++ L +S S+ E+ E + V Sbjct: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMV 442 Query: 244 QVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLT------------- 290 P +A AL + G +S S D+SS + + Sbjct: 443 ATTKP---KATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499 Query: 291 --VPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKK 338 P KPA +K E + S D+ + E+ L G RP K Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSSE----EEEEKLKGKGSPRPQAPK 545 >gi|83716021 GRB2-associated binding protein family, member 4 [Homo sapiens] Length = 574 Score = 43.1 bits (100), Expect = 5e-04 Identities = 44/168 (26%), Positives = 66/168 (39%), Gaps = 22/168 (13%) Query: 41 GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNL- 92 GH GWL K + W+K W IL+ L +Y N ++K +NL Sbjct: 38 GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97 Query: 93 ------PDFTVE-RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQE 144 D T+ E +K + F I + +TFY AE ++MN W+ + QE Sbjct: 98 LCEQLDVDVTLNFNKKEIQKGYMFDIKTSE-RTFYLVAETREDMNEWVQSICQICGFRQE 156 Query: 145 STTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLS 192 +T S + +P P S Q L +Q +S P +S Sbjct: 157 ESTGFLGNISSASHG----LCSSPAEPSCSH-QHLPQEQEPTSEPPVS 199 >gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo sapiens] Length = 2364 Score = 43.1 bits (100), Expect = 5e-04 Identities = 40/165 (24%), Positives = 68/165 (41%), Gaps = 33/165 (20%) Query: 43 ADCQGWLYKKKE------KGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGF------- 89 A +G+L +K E K S S W + ++ + +Y + A G Sbjct: 2198 AQMEGFLNRKHEWEAHNKKAS--SRSWHNVYCVINNQEMGFYKDAKTA-ASGIPYHSEVP 2254 Query: 90 VNLPDFTVERASECKKK-HAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTK 148 V+L + E A + KKK H FK+ + F A++ +EMN W+ + SA+ Sbjct: 2255 VSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAI-------- 2306 Query: 149 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSG 193 + E++A T P +S+ Q+L + +S S G Sbjct: 2307 --------SSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPG 2343 >gi|46195763 metastasis suppressor 1-like [Homo sapiens] Length = 747 Score = 43.1 bits (100), Expect = 5e-04 Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 12/141 (8%) Query: 191 LSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVP 250 L G+ YS+S +TP S PSS S + S+ +S S+A+ G P Q +S P Sbjct: 249 LKGSDYSWS-----YQTPPSSPSSSSSRKSSMCSAPSSSSSAKGGGAPWPGGAQTYS--P 301 Query: 251 SEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSE 310 S +++L T+ L+S+SS D+ +S + + + P P S I ++ + S Sbjct: 302 SSTCRYRSLAQPATTTAR--LSSVSSHDSGFVSQDATY-SKPPSPMPSDITSQKSSS-SA 357 Query: 311 DDEMEKLYKSLEQASLSPLGD 331 E + +S+ + S SP D Sbjct: 358 SSEASETCQSVSECS-SPTSD 377 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 43.1 bits (100), Expect = 5e-04 Identities = 50/193 (25%), Positives = 74/193 (38%), Gaps = 10/193 (5%) Query: 159 EDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKE 218 + P A P + S ++ +SSSS S S +S S S ++ SS P Sbjct: 2516 QQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVA 2575 Query: 219 RQSLPDTVNSLSAAEDEGQP--ITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSS 276 + +P + A EG+P T A + S + + +S +S S +S SS Sbjct: 2576 LKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2635 Query: 277 DDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEM-----EKLYKSLEQA---SLSP 328 +SS SS+ P KP + K E K SL + S SP Sbjct: 2636 SSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695 Query: 329 LGDRRPSTKKELR 341 + RRPS + R Sbjct: 2696 VERRRPSPQPSPR 2708 Score = 35.0 bits (79), Expect = 0.13 Identities = 24/78 (30%), Positives = 36/78 (46%) Query: 146 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 205 T +E E +P A +S + S ++ +SSSS S S +S S SS ++ Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642 Query: 206 KTPSSFPSSLSKERQSLP 223 + SS PS Q+LP Sbjct: 2643 SSSSSSPSPAKPGPQALP 2660 Score = 32.0 bits (71), Expect = 1.1 Identities = 50/206 (24%), Positives = 80/206 (38%), Gaps = 31/206 (15%) Query: 147 TKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSS--PSLSGTSYSFSSLENT 204 T + +S S P++ A+TPP P S ++S Q+ S S S G+ + ++++ Sbjct: 983 TPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSS 1042 Query: 205 VKTPSSF----PSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 260 S+ L + Q+ PD + S+ E Q HS PS L+ Sbjct: 1043 TPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPE--------VRQSHSESPS-------LQ 1087 Query: 261 NSFVTSESGFLNSLSSDDTSSLSS----NHDHLTVPDKPAGSKIMDKEETKVSEDDEMEK 316 + TS G S SS + L+S D P M E+++ D Sbjct: 1088 SKSQTSPKGG-RSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSS-- 1144 Query: 317 LYKSLEQASLSPLGDRRPSTKKELRK 342 Y +++ SL LG R T + K Sbjct: 1145 -YPTVDSNSL--LGQSRLETAESKEK 1167 >gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] Length = 1958 Score = 42.7 bits (99), Expect = 6e-04 Identities = 55/239 (23%), Positives = 105/239 (43%), Gaps = 21/239 (8%) Query: 31 SRRRISCKDLGHADCQGWLYKKK---EKGSFLSNK---WKKFWVILKGSSLYWYSNQMAE 84 SR+ S + A +GWL+ + +KG + WK+ +V+L+G SLY Y ++ + Sbjct: 920 SRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQ 979 Query: 85 KADGFVNLPDFTVERA------SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKL-G 137 P +V SE K+K+ F+++ + F AE+ +M W+ + Sbjct: 980 TTPSEEEQP-ISVNACLIDISYSETKRKNVFRLTTSDCECL-FQAEDRDDMLAWIKTIQE 1037 Query: 138 SAVIHQEST-TKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSY 196 S+ +++E T + + S +E + ++ P + QSL+ +Q + S T Sbjct: 1038 SSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPR-QSLSIRQTLLGAKSEPKTQS 1096 Query: 197 SFSSLENTV-KTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPI---TFAVQVHSPVPS 251 S E + K S +S K++ + + S+ E +P TF V++ P+ Sbjct: 1097 PHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPA 1155 >gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [Homo sapiens] Length = 1704 Score = 42.0 bits (97), Expect = 0.001 Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 7/104 (6%) Query: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKK 106 GWL K +G + ++K WV G S+ +Y+N+ + G + L + R K Sbjct: 487 GWLDKLSPQGKRM---FQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK- 542 Query: 107 HAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 150 F++ Q +TF F E +E N W++ L +A+ Q T++ + Sbjct: 543 --FEVVTTQ-RTFVFRVEKEEERNDWISILLNALKSQSLTSQSQ 583 Score = 32.0 bits (71), Expect = 1.1 Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 24/103 (23%) Query: 48 WLYKKKEKGSFLSNKWK------KFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERAS 101 +LY+ S LS++ K K W +L+G L +Y N + +G +N+ + Sbjct: 898 FLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVI----- 952 Query: 102 ECKKKH------------AFKISHPQIKTFYFAAENVQEMNVW 132 C H F+I P + F F AE Q W Sbjct: 953 -CLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKW 994 >gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens] Length = 2365 Score = 42.0 bits (97), Expect = 0.001 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%) Query: 60 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 116 +++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H + Sbjct: 1804 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 1862 Query: 117 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 176 + +A W+ L V + ++ D S+S +E+ + T P + Sbjct: 1863 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 1920 Query: 177 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 220 Q ++ S P G + +E +TP+ P L+K+ + Sbjct: 1921 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 1974 >gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sapiens] Length = 431 Score = 42.0 bits (97), Expect = 0.001 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%) Query: 60 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 116 +++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H + Sbjct: 91 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149 Query: 117 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 176 + +A W+ L V + ++ D S+S +E+ + T P + Sbjct: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207 Query: 177 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 220 Q ++ S P G + +E +TP+ P L+K+ + Sbjct: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261 >gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sapiens] Length = 652 Score = 42.0 bits (97), Expect = 0.001 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%) Query: 60 SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 116 +++WKK W +L SSL +Y + AE+A DG ++L T ++ + F+I H + Sbjct: 91 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149 Query: 117 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 176 + +A W+ L V + ++ D S+S +E+ + T P + Sbjct: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207 Query: 177 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 220 Q ++ S P G + +E +TP+ P L+K+ + Sbjct: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.124 0.352 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,080,224 Number of Sequences: 37866 Number of extensions: 851258 Number of successful extensions: 5513 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 107 Number of HSP's successfully gapped in prelim test: 369 Number of HSP's that attempted gapping in prelim test: 4812 Number of HSP's gapped (non-prelim): 1012 length of query: 438 length of database: 18,247,518 effective HSP length: 105 effective length of query: 333 effective length of database: 14,271,588 effective search space: 4752438804 effective search space used: 4752438804 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.