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Search of human proteins with 194394161
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
(239 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 465 e-131
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 103 1e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 101 7e-22
gi|238908508 leucine-rich repeat and death domain-containing pro... 100 2e-21
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 99 2e-21
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 95 6e-20
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 92 3e-19
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 92 4e-19
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 91 7e-19
gi|45827729 scribble isoform b [Homo sapiens] 89 3e-18
gi|45827731 scribble isoform a [Homo sapiens] 89 3e-18
gi|4503743 flightless I homolog [Homo sapiens] 89 4e-18
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 88 7e-18
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 87 1e-17
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 87 1e-17
gi|62241040 leucine rich repeat containing 8 family, member A [H... 87 2e-17
gi|187829877 leucine rich repeat containing 8 family, member A [... 87 2e-17
gi|187829871 leucine rich repeat containing 8 family, member A [... 87 2e-17
gi|61742786 leucine rich repeat and death domain containing prot... 85 5e-17
gi|61742784 leucine rich repeat and death domain containing prot... 85 5e-17
gi|190014581 leucine rich repeat containing 2 [Homo sapiens] 85 5e-17
gi|27545328 leucine rich repeat containing 2 [Homo sapiens] 85 5e-17
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 85 5e-17
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 84 8e-17
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 84 1e-16
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 83 2e-16
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 82 3e-16
gi|167466264 leucine rich repeat containing 18 [Homo sapiens] 82 5e-16
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 82 5e-16
gi|53729363 leucine rich repeat and sterile alpha motif containi... 81 7e-16
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 465 bits (1196), Expect = e-131
Identities = 239/239 (100%), Positives = 239/239 (100%)
Query: 1 MGNSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGK 60
MGNSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGK
Sbjct: 1 MGNSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGK 60
Query: 61 FTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL 120
FTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL
Sbjct: 61 FTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQL 120
Query: 121 GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKI 180
GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKI
Sbjct: 121 GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKI 180
Query: 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA 239
LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA
Sbjct: 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTATKKKFA 239
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 103 bits (257), Expect = 1e-22
Identities = 69/205 (33%), Positives = 114/205 (55%), Gaps = 13/205 (6%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
LT P +L NL + +++ ++SLP IG L SL L N LT LPD + L+
Sbjct: 117 LTRLPESFPEL-QNLTCLSVNDISLQSLPEN-IGNLYNLASLELRENLLTYLPDSLTQLR 174
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
+LE L L NN + LP + G L LK L L GNQL LP ++ +L++L +D+S+N++
Sbjct: 175 RLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLER 234
Query: 146 IPDSV-GELQVIELNLNQNQISQISVKISCCPRLKILRLEENCL--------ELSMLPQS 196
+P+ + G + +L ++QN + I I +L IL++++N L E L +
Sbjct: 235 LPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
Query: 197 ILSDSQICLLAVEGNLFEIKKLREL 221
+L+++Q LL + ++ ++KKL L
Sbjct: 295 VLTENQ--LLTLPKSIGKLKKLSNL 317
Score = 89.4 bits (220), Expect = 3e-18
Identities = 68/207 (32%), Positives = 104/207 (50%), Gaps = 10/207 (4%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L D + P ++ L +D+S N+I +P I L+ + N LT LP+
Sbjct: 66 LSDNEIQRLPPEIANFMQ-LVELDVSRNEIPEIPES-ISFCKALQVADFSGNPLTRLPES 123
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
L+ L LS+N+ L+ LP G L L +L L N L LP L LR L+ +DL
Sbjct: 124 FPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGN 183
Query: 141 NQIRSIPDSVGE-LQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILS 199
N+I ++P+S+G L + +L L+ NQ+S++ +I L L + EN LE LP+ I
Sbjct: 184 NEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLE--RLPEEISG 241
Query: 200 DSQICLLAVEGNLFE-----IKKLREL 221
+ + L + NL E I KL++L
Sbjct: 242 LTSLTDLVISQNLLETIPDGIGKLKKL 268
Score = 84.0 bits (206), Expect = 1e-16
Identities = 55/173 (31%), Positives = 92/173 (53%), Gaps = 5/173 (2%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L+E P ++ L NL +D+S N++E LP + G T L L ++ N L +PD I LK
Sbjct: 209 LSELPQEIGNL-KNLLCLDVSENRLERLPEEISG-LTSLTDLVISQNLLETIPDGIGKLK 266
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
KL L ++ N L +LP G+ +L L L+ NQL LP + L+ L ++ +N++ S
Sbjct: 267 KLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVS 326
Query: 146 IPDSVGE-LQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSI 197
+P +G + + N++++I ++S L +L + N L LP S+
Sbjct: 327 LPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGN--RLLHLPLSL 377
Score = 72.4 bits (176), Expect = 3e-13
Identities = 52/170 (30%), Positives = 91/170 (53%), Gaps = 11/170 (6%)
Query: 64 LKSLSLNNNKLTVLPDEICNL-KKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGA 122
++S+ + L +P+EI + LE L L+ N LRELP F QL L+ L LS N++
Sbjct: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73
Query: 123 LPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL-NLNQNQISQISVKISCCPRLKIL 181
LPP++ + L +D+S+N+I IP+S+ + +++ + + N ++++ P L+ L
Sbjct: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESF---PELQNL 130
Query: 182 R-LEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELEGYD 225
L N + L LP++I + + L + NL + +LR LE D
Sbjct: 131 TCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELD 180
Score = 65.5 bits (158), Expect = 4e-11
Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 33 LQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSL 92
L + ++ +ID + + +P + L+ L L+ N+L LP++ L KL L L
Sbjct: 7 LWRCNRHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGL 66
Query: 93 NNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGE 152
++N ++ LP L L +S N++ +P + + L V D S N + +P+S E
Sbjct: 67 SDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPE 126
Query: 153 LQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSI 197
LQ + L++N + + I L L L EN L+ LP S+
Sbjct: 127 LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENL--LTYLPDSL 170
Score = 64.3 bits (155), Expect = 9e-11
Identities = 50/175 (28%), Positives = 77/175 (44%), Gaps = 13/175 (7%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L P + KL L + + N++ LP +G+ L L L N+L LP I LK
Sbjct: 255 LETIPDGIGKL-KKLSILKVDQNRLTQLPEA-VGECESLTELVLTENQLLTLPKSIGKLK 312
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
KL L+ + N L LP G +L + N+L +P ++ L V+D++ N++
Sbjct: 313 KLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLH 372
Query: 146 IPDSVGELQVIELNLNQNQISQI-----------SVKISCCPRLKILRLEENCLE 189
+P S+ L++ L L+ NQ + KI C L L E C E
Sbjct: 373 LPLSLTALKLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQE 427
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 101 bits (251), Expect = 7e-22
Identities = 66/192 (34%), Positives = 110/192 (57%), Gaps = 5/192 (2%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L R + P+ +++LT L + L +NK++SLP +G L +L+L+ N LT LPD
Sbjct: 107 LSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAE-VGCLVNLMTLALSENSLTSLPDS 164
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
+ NLKKL L L +N LRE+PS +L +L TL L N++ + + +L L ++ + +
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Query: 141 NQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILS 199
N+I+ +P +GEL +I L++ NQ+ + +I C ++ L L+ N EL LP +I +
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHN--ELLDLPDTIGN 282
Query: 200 DSQICLLAVEGN 211
S + L + N
Sbjct: 283 LSSLSRLGLRYN 294
Score = 90.5 bits (223), Expect = 1e-18
Identities = 55/185 (29%), Positives = 102/185 (55%), Gaps = 3/185 (1%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
+ + P + L +++ +N++ SLP L G +T + L+L N+LT +P+++ L
Sbjct: 367 INKIPFGIFSRAKVLSKLNMKDNQLTSLP-LDFGTWTSMVELNLATNQLTKIPEDVSGLV 425
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
LE L L+NN L++LP G L L+ L L N+L +LP ++ L+ L + L+ NQ+ +
Sbjct: 426 SLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTT 485
Query: 146 IPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQIC 204
+P +G L + L L +N ++ + +I L+ L L +N L LP + S++
Sbjct: 486 LPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN-PNLHSLPFELALCSKLS 544
Query: 205 LLAVE 209
++++E
Sbjct: 545 IMSIE 549
Score = 75.9 bits (185), Expect = 3e-14
Identities = 64/233 (27%), Positives = 113/233 (48%), Gaps = 34/233 (14%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLI---------------------- 58
L+ L+ P L K ++ L ++L NN I +LP L+
Sbjct: 291 LRYNRLSAIPRSLAKCSA-LEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
Query: 59 --GKFTLLKSLSLNNNKLTVLPDEI-CNLKKLETLSLNNNHLRELPSTFGQLSALKTLSL 115
+F+ + SL++ +N++ +P I K L L++ +N L LP FG +++ L+L
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Query: 116 SGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-ELNLNQNQISQISVKISC 174
+ NQL +P + L L+V+ LS N ++ +P +G L+ + EL+L +N++ + +I+
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAY 469
Query: 175 CPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELE 222
L+ L L N +L+ LP+ I + + L + NL EI L LE
Sbjct: 470 LKDLQKLVLTNN--QLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLE 520
Score = 75.5 bits (184), Expect = 4e-14
Identities = 53/170 (31%), Positives = 82/170 (48%), Gaps = 23/170 (13%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L+ +T D++ L S L + + NKI+ LP IG+ L +L + +N+L LP E
Sbjct: 199 LRFNRITTVEKDIKNL-SKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQLEHLPKE 256
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
I N ++ L L +N L +LP T G LS+L L L N+L A+P L L+ ++L
Sbjct: 257 IGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLEN 316
Query: 141 NQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKILRLEENCLEL 190
N I ++P+S+ +S +L L L NC +L
Sbjct: 317 NNISTLPESL---------------------LSSLVKLNSLTLARNCFQL 345
Score = 71.6 bits (174), Expect = 6e-13
Identities = 51/149 (34%), Positives = 76/149 (51%), Gaps = 3/149 (2%)
Query: 67 LSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQ 126
L L+ + +LP I L +L L L +N L+ LP+ G L L TL+LS N L +LP
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 127 LCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRLEE 185
L +L+ L ++DL N++R IP V L + L L N+I+ + I +L +L + E
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Query: 186 NCLELSMLPQSILSDSQICLLAVEGNLFE 214
N ++ LP I + L V N E
Sbjct: 225 N--KIKQLPAEIGELCNLITLDVAHNQLE 251
Score = 58.9 bits (141), Expect = 4e-09
Identities = 48/133 (36%), Positives = 59/133 (44%), Gaps = 24/133 (18%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------P 55
V L + L + P L L LR +DL NK+ESLP P
Sbjct: 429 VLILSNNLLKKLPHGLGNLRK-LRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLP 487
Query: 56 LLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNN-HLRELPSTFGQLSALKTLS 114
IG T L L L N LT LP+EI L+ LE L LN+N +L LP S L +S
Sbjct: 488 RGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMS 547
Query: 115 LSGNQLGALPPQL 127
+ L LPPQ+
Sbjct: 548 IENCPLSHLPPQI 560
Score = 52.4 bits (124), Expect = 3e-07
Identities = 39/138 (28%), Positives = 74/138 (53%), Gaps = 5/138 (3%)
Query: 82 CNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKN 141
C + L L+ + LPS+ +L+ L L L N+L +LP ++ L +L + LS+N
Sbjct: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSEN 156
Query: 142 QIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSD 200
+ S+PDS+ L+ + L+L N++ +I + L L L N ++ + + I +
Sbjct: 157 SLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN--RITTVEKDIKNL 214
Query: 201 SQICLLAVEGNLFEIKKL 218
S++ +L++ N +IK+L
Sbjct: 215 SKLSMLSIREN--KIKQL 230
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 99.8 bits (247), Expect = 2e-21
Identities = 67/218 (30%), Positives = 115/218 (52%), Gaps = 12/218 (5%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L+ +GL EFP D+ K+ ++ + L N+I++ G L+ LSL N L+ LP E
Sbjct: 148 LEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSE 206
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
I L L L++++NH+ +P QL ++ L N + P L L +L+++ L K
Sbjct: 207 IQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGK 266
Query: 141 NQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCL--------ELS 191
N++R IPD++ L+ + LNL NQ++ + P+L L L N + EL
Sbjct: 267 NKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326
Query: 192 MLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
L ++ +++ LAVE +F++ K++EL+ D +E
Sbjct: 327 NLETLLMDHNKLTFLAVE--IFQLLKIKELQLADNKLE 362
Score = 81.6 bits (200), Expect = 5e-16
Identities = 59/226 (26%), Positives = 111/226 (49%), Gaps = 12/226 (5%)
Query: 10 VETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSL 69
++ QK +L + FP L L S L + ++ N I +P + LL L L
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLCALDS-LYYLSVNGNYISEIPVDISFSKQLLH-LEL 517
Query: 70 NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS 129
+ NKL + + C+L L+ L L N ++++P++ + +L L L N+ P +LC+
Sbjct: 518 SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCT 577
Query: 130 LRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEE-NC 187
L +L V+DLS+NQ++ I + L+ I+ LN + NQ +++ L+ L + +
Sbjct: 578 LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKG 637
Query: 188 LELSMLPQSILSDSQI--------CLLAVEGNLFEIKKLRELEGYD 225
+L+ LP + + +Q+ + + N+ E++ L L Y+
Sbjct: 638 RKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYN 683
Score = 77.8 bits (190), Expect = 8e-15
Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 31/224 (13%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTL---------------------- 63
+ FP+DL+ L NL + L NK+ +P L TL
Sbjct: 246 IENFPSDLECL-GNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
Query: 64 LKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGAL 123
L SL L N ++ LP EI LK LETL +++N L L QL +K L L+ N+L +
Sbjct: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
Query: 124 PPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILR 182
++ + R L ++ L KN +++IP+ + ++E L+L+ N+++++ I L+ L
Sbjct: 365 SHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLH 424
Query: 183 LEENCLELSMLPQSILSDSQICLLAVEGNL-----FEIKKLREL 221
+ N + + I + IC L GN+ EIK +++
Sbjct: 425 VNRN--NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKI 466
Score = 75.9 bits (185), Expect = 3e-14
Identities = 48/164 (29%), Positives = 86/164 (52%), Gaps = 4/164 (2%)
Query: 12 TAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTL--LKSLSL 69
T + V L + L + +D+ L ++ ++ S+N+ P L +L L +
Sbjct: 577 TLENLQVLDLSENQLQKISSDICNL-KGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQI 635
Query: 70 NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS 129
KLT LP E+ N+ +L+ L ++NN +RE+P G+L L +L NQ+ LPP L S
Sbjct: 636 KGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLS 695
Query: 130 LRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKI 172
L L ++LS N + ++P ++ + + E+N + N + + V+I
Sbjct: 696 LNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 71.6 bits (174), Expect = 6e-13
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 10 VETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSL 69
+++ ++ + Q+K R LT P +L +T L+ +D+SNN I +P IG+ L SL
Sbjct: 624 LQSLEQLNISQIKGRKLTRLPGELSNMTQ-LKELDISNNAIREIPRN-IGELRNLVSLHA 681
Query: 70 NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS 129
NN+++ LP + +L L+ L+L+ N+L LPS + +LK ++ N L P ++C
Sbjct: 682 YNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICK 741
Query: 130 LRHL 133
+ L
Sbjct: 742 GKQL 745
Score = 70.9 bits (172), Expect = 9e-13
Identities = 64/230 (27%), Positives = 99/230 (43%), Gaps = 31/230 (13%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------PLLI 58
L D LTE P + KL +NLR + ++ N + + P+ I
Sbjct: 402 LSDNKLTELPKYIHKL-NNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEI 460
Query: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN 118
+ + L+ NK+ P +C L L LS+N N++ E+P L L LS N
Sbjct: 461 KNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSEN 520
Query: 119 QLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPR 177
+L CSL +L +DL KNQI+ IP S+ + + L L N+ ++
Sbjct: 521 KLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLEN 580
Query: 178 LKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELE 222
L++L L EN +L + I + I L N F E+ +L+ LE
Sbjct: 581 LQVLDLSEN--QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLE 628
Score = 68.6 bits (166), Expect = 5e-12
Identities = 49/150 (32%), Positives = 82/150 (54%), Gaps = 2/150 (1%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
LR + L N ++++P I +L+ LSL++NKLT LP I L L L +N N++ +
Sbjct: 374 LRILILDKNLLKNIPEK-ISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVK 432
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIEL 158
+ L+ + +L SGN + +P ++ + + + ++LS N+I P + L + L
Sbjct: 433 ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYL 492
Query: 159 NLNQNQISQISVKISCCPRLKILRLEENCL 188
++N N IS+I V IS +L L L EN L
Sbjct: 493 SVNGNYISEIPVDISFSKQLLHLELSENKL 522
Score = 40.4 bits (93), Expect = 0.001
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 27/148 (18%)
Query: 89 TLSLNNNHLRELPSTFGQLSALKTLSLSGNQ------------------------LGALP 124
T++L L+E P ++ +K L L NQ L +LP
Sbjct: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
Query: 125 PQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRL 183
++ L +L ++++S N I IP + +L + +L N I + C L+IL L
Sbjct: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 184 EENCLELSMLPQSILSDSQICLLAVEGN 211
+N +L +P ++ S + +L +E N
Sbjct: 265 GKN--KLRHIPDTLPSLKTLRVLNLEYN 290
Score = 39.7 bits (91), Expect = 0.002
Identities = 34/122 (27%), Positives = 62/122 (50%), Gaps = 19/122 (15%)
Query: 112 TLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDS-VGELQVIE-LNLNQNQISQIS 169
T++L L P + ++++ + L KNQI++ + G+L +E L+L +N +S +
Sbjct: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
Query: 170 VKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
+I L+IL + N +S +P+ I SQ+ GN +R+L Y+ Y+E
Sbjct: 205 SEIQLLHNLRILNVSHN--HISHIPKEI---SQL------GN------IRQLFFYNNYIE 247
Query: 230 RF 231
F
Sbjct: 248 NF 249
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 99.4 bits (246), Expect = 2e-21
Identities = 65/210 (30%), Positives = 108/210 (51%), Gaps = 26/210 (12%)
Query: 4 SALRAHVETAQKTGVFQLKDRGLTEFPADLQKL--TSNLRTIDLSNNKIESLPPL----- 56
SA RA +E A TG L +R L FP + S++ DLS N+ +P
Sbjct: 33 SAERA-LEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLV 91
Query: 57 -----------------LIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
+G T L L+L+ N+L++LP IC L L L ++NN L
Sbjct: 92 SLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGA 150
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELN 159
LP G L +L+ L +S N+L +LP +LC L L +++ +NQ+ ++P+ +G+L ++ L+
Sbjct: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLD 210
Query: 160 LNQNQISQISVKISCCPRLKILRLEENCLE 189
+ N++S+I V L+++ L+ N L+
Sbjct: 211 FSCNRVSRIPVSFCRLRHLQVILLDSNPLQ 240
Score = 77.0 bits (188), Expect = 1e-14
Identities = 45/121 (37%), Positives = 68/121 (56%), Gaps = 5/121 (4%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
LR + +SNNK+ +LPP IG L+ L +++N+L LP E+C L L L++ N L
Sbjct: 138 LRVLIVSNNKLGALPPD-IGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLST 196
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV---GELQVI 156
LP G L ++ L S N++ +P C LRHL V+ L N ++S P V G+L +
Sbjct: 197 LPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIF 255
Query: 157 E 157
+
Sbjct: 256 K 256
Score = 58.5 bits (140), Expect = 5e-09
Identities = 40/136 (29%), Positives = 72/136 (52%), Gaps = 3/136 (2%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
V + + L P D+ L S LR +D+S+N+++SLP L G + L+ L++ N+L+ L
Sbjct: 140 VLIVSNNKLGALPPDIGTLGS-LRQLDVSSNELQSLPSELCG-LSSLRDLNVRRNQLSTL 197
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMD 137
P+E+ +L L L + N + +P +F +L L+ + L N L + P Q+C L +
Sbjct: 198 PEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFK 256
Query: 138 LSKNQIRSIPDSVGEL 153
+ ++G+L
Sbjct: 257 YLSTEAGQRGSALGDL 272
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 94.7 bits (234), Expect = 6e-20
Identities = 66/213 (30%), Positives = 114/213 (53%), Gaps = 8/213 (3%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
V + D LT P+ +++L NL+ +++S+NK++ LP I LK L L +N+LT +
Sbjct: 109 VLDIHDNQLTSLPSAIREL-ENLQKLNVSHNKLKILPEE-ITNLRNLKCLYLQHNELTCI 166
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMD 137
+ L LE L L+NNHL +P++F LS+L L+LS N+L +LP ++ ++ L +D
Sbjct: 167 SEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLD 226
Query: 138 LSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSI 197
+ N + +IP + ++ +EL + + + C LK L + EN +E+ + + +
Sbjct: 227 CNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEM-LEAEHL 285
Query: 198 LSDSQICLLAVEGNLF-----EIKKLRELEGYD 225
+ I +L + N EI LR LE D
Sbjct: 286 KHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
Score = 80.9 bits (198), Expect = 9e-16
Identities = 62/214 (28%), Positives = 105/214 (49%), Gaps = 5/214 (2%)
Query: 2 GNSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKF 61
G S + ++ A+K+G L R L+E P + ++ N+ + +N + +
Sbjct: 24 GTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRI--NVDIPEEANQNLSFGATERWWEQ 81
Query: 62 TLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLG 121
T L L ++NNKL L D++ L L L +++N L LPS +L L+ L++S N+L
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 122 ALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKI 180
LP ++ +LR+L + L N++ I + +L +E L+L+ N ++ + S L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFE 214
L L N EL LP I ++ L NL E
Sbjct: 202 LNLSSN--ELKSLPAEINRMKRLKHLDCNSNLLE 233
Score = 76.3 bits (186), Expect = 2e-14
Identities = 56/175 (32%), Positives = 86/175 (49%), Gaps = 25/175 (14%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L + LT PA L+S +R ++LS+N+++SLP I + LK L N+N L +P E
Sbjct: 181 LSNNHLTTVPASFSSLSSLVR-LNLSSNELKSLPAE-INRMKRLKHLDCNSNLLETIPPE 238
Query: 81 ICNLKKLETLSLNNNHLRELPST-----------------------FGQLSALKTLSLSG 117
+ ++ LE L L N LR LP L+++ L L
Sbjct: 239 LAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRD 298
Query: 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKI 172
N+L ++P ++ LR L+ +DLS N I S+P S+G L + L L N + I +I
Sbjct: 299 NKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREI 353
Score = 75.1 bits (183), Expect = 5e-14
Identities = 53/187 (28%), Positives = 95/187 (50%), Gaps = 4/187 (2%)
Query: 4 SALRAHVETAQKTGVFQLKDRGLTEFPADL-QKLTSNLRT-IDLSNNKIESLPPLLIGKF 61
S R ++ + D+ T P ++ + SN+ T I+ S N++ +P ++
Sbjct: 389 SESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELK 448
Query: 62 TLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLG 121
++ + L+ NKL+ + E+C L+KL L L NN L LP L L+T++LS N+
Sbjct: 449 EMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
Query: 122 ALPPQLCSLRHLDVMDLSKNQIRSI-PDSVGELQ-VIELNLNQNQISQISVKISCCPRLK 179
LP L + L+ + +S NQ+ S+ P + ++ + L+L N + QI ++ C L+
Sbjct: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
Query: 180 ILRLEEN 186
L L+ N
Sbjct: 569 TLLLDGN 575
Score = 60.5 bits (145), Expect = 1e-09
Identities = 44/131 (33%), Positives = 67/131 (51%), Gaps = 6/131 (4%)
Query: 22 KDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEI 81
K R L EFP+ S L+ + + N+IE L + + L L +NKL +PDEI
Sbjct: 254 KLRFLPEFPS-----CSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI 308
Query: 82 CNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKN 141
L+ LE L L+NN + LP + G L LK L+L GN L + ++ S +V+ ++
Sbjct: 309 ILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRS 367
Query: 142 QIRSIPDSVGE 152
+I+ S E
Sbjct: 368 KIKDDGPSQSE 378
Score = 55.8 bits (133), Expect = 3e-08
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 29/231 (12%)
Query: 9 HVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS 68
H++ V L+D L P ++ L S L +DLSNN I SLP L LK L+
Sbjct: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRS-LERLDLSNNDISSLPYSLGNLH--LKFLA 340
Query: 69 LNNNKLTVLPDEICNLKKLETLSLNNNHLRE---------------LPS----TFGQLSA 109
L N L + EI + E L + +++ LPS +
Sbjct: 341 LEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIIT 400
Query: 110 LKTLSLSGNQLGALPPQLCSLRHLDVM---DLSKNQIRSIPDSVGELQ--VIELNLNQNQ 164
LK L S Q +P ++ +++ + SKNQ+ IP + EL+ V +++L+ N+
Sbjct: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNK 460
Query: 165 ISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEI 215
+S IS+++ +L L L N L+ LP+ + S ++ + + N F++
Sbjct: 461 LSFISLELCVLQKLTFLDLRNNF--LNSLPEEMESLVRLQTINLSFNRFKM 509
Score = 40.8 bits (94), Expect = 0.001
Identities = 23/59 (38%), Positives = 32/59 (54%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
L TI +SNN++ S+ P + L +L L NN L +P E+ N L TL L+ N R
Sbjct: 520 LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFR 578
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 92.4 bits (228), Expect = 3e-19
Identities = 66/235 (28%), Positives = 114/235 (48%), Gaps = 31/235 (13%)
Query: 15 KTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLL----------------- 57
K + +L++ L P + KL + L +DL NN+ LP +L
Sbjct: 162 KLRILELRENHLKTLPKSMHKL-AQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQ 220
Query: 58 -----IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKT 112
IGK +L L ++ N++ + +I + LE L L++N L++LP + G L L T
Sbjct: 221 VLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTT 280
Query: 113 LSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVK 171
L + NQL LP + +L L+ D S N++ S+P ++G L + L +++N + ++ +
Sbjct: 281 LKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPRE 340
Query: 172 ISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNL-----FEIKKLREL 221
I C + ++ L N LE LP+ I ++ +L + N F KL+EL
Sbjct: 341 IGSCKNVTVMSLRSNKLE--FLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKEL 393
Score = 88.6 bits (218), Expect = 4e-18
Identities = 51/148 (34%), Positives = 86/148 (58%), Gaps = 2/148 (1%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRE 99
L + LS+N ++ LP IG L +L +++N+LT+LP+ I NL LE + N L
Sbjct: 255 LEDLLLSSNMLQQLPDS-IGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELES 313
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-L 158
LPST G L +L+TL++ N L LP ++ S +++ VM L N++ +P+ +G++Q + L
Sbjct: 314 LPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVL 373
Query: 159 NLNQNQISQISVKISCCPRLKILRLEEN 186
NL+ N++ + + L L L +N
Sbjct: 374 NLSDNRLKNLPFSFTKLKELAALWLSDN 401
Score = 83.6 bits (205), Expect = 1e-16
Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 26/200 (13%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------PLLI 58
+ G+ EFP ++ K L I+ S N I LP P
Sbjct: 99 ISKNGVQEFPENI-KCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANF 157
Query: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN 118
G+ L+ L L N L LP + L +LE L L NN ELP Q+ L+ L + N
Sbjct: 158 GRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNN 217
Query: 119 QLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPR 177
L LP + L+ L +D+SKN+I ++ + + +E L L+ N + Q+ I +
Sbjct: 218 ALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKK 277
Query: 178 LKILRLEENCLELSMLPQSI 197
L L++++N +L+MLP +I
Sbjct: 278 LTTLKVDDN--QLTMLPNTI 295
Score = 72.0 bits (175), Expect = 4e-13
Identities = 48/133 (36%), Positives = 72/133 (54%), Gaps = 2/133 (1%)
Query: 14 QKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNK 73
+K ++ D LT P + L S L D S N++ESLP IG L++L+++ N
Sbjct: 276 KKLTTLKVDDNQLTMLPNTIGNL-SLLEEFDCSCNELESLPST-IGYLHSLRTLAVDENF 333
Query: 74 LTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHL 133
L LP EI + K + +SL +N L LP GQ+ L+ L+LS N+L LP L+ L
Sbjct: 334 LPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKEL 393
Query: 134 DVMDLSKNQIRSI 146
+ LS NQ +++
Sbjct: 394 AALWLSDNQSKAL 406
Score = 64.7 bits (156), Expect = 7e-11
Identities = 63/255 (24%), Positives = 100/255 (39%), Gaps = 71/255 (27%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------PLLIGKFTL 63
L + P ++ L + L N+IE LP P I
Sbjct: 34 LQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93
Query: 64 LKSLSLNN-----------------------NKLTVLPDEICNLKKLETLSLNNNHLREL 100
LK L ++ N ++ LPD L L L LN+ L L
Sbjct: 94 LKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL 153
Query: 101 PSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQ------------------ 142
P+ FG+L L+ L L N L LP + L L+ +DL N+
Sbjct: 154 PANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELW 213
Query: 143 -----IRSIPDSVGELQ-VIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQS 196
++ +P S+G+L+ ++ L++++N+I + + IS C L+ L L N L+ LP S
Sbjct: 214 MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQ--QLPDS 271
Query: 197 ILSDSQICLLAVEGN 211
I ++ L V+ N
Sbjct: 272 IGLLKKLTTLKVDDN 286
Score = 62.0 bits (149), Expect = 4e-10
Identities = 53/196 (27%), Positives = 88/196 (44%), Gaps = 35/196 (17%)
Query: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
G+ ++ L ++ L +P E+ N ++ LE L L+ N + ELP AL+ LS+
Sbjct: 19 GEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPD 78
Query: 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV------------------------GEL 153
N L LP + SL +L +D+SKN ++ P+++ L
Sbjct: 79 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 138
Query: 154 QVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF 213
+ +L LN + + +L+IL L EN L LP+S+ +Q+ L + N F
Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLVKLRILELREN--HLKTLPKSMHKLAQLERLDLGNNEF 196
Query: 214 --------EIKKLREL 221
+I+ LREL
Sbjct: 197 GELPEVLDQIQNLREL 212
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 92.0 bits (227), Expect = 4e-19
Identities = 62/202 (30%), Positives = 102/202 (50%), Gaps = 28/202 (13%)
Query: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
N + I L+ K+ +P L GK LK+L L NN + + E+CNL +L TL+L NN L
Sbjct: 15 NTKIITLNGKKMTKMPSAL-GKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLC-SLRHLDVMDLSKNQIRSIPDSVGELQ--- 154
E+P L++LK L LSGN++ P C L++L +++L+ N + +P V L+
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLT 133
Query: 155 ---------------------VIELNLNQNQISQISVKISCCPRLKILRLEENCLELSML 193
++EL LN NQ+ I +I +L+ L L N + +L
Sbjct: 134 YMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN--NIGVL 191
Query: 194 PQSILSDSQICLLAVEGNLFEI 215
P+ + ++ +L + GN+ +I
Sbjct: 192 PEELCDLKKLRILDIAGNIIQI 213
Score = 74.3 bits (181), Expect = 9e-14
Identities = 42/127 (33%), Positives = 69/127 (54%), Gaps = 1/127 (0%)
Query: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
NL ++L+NN + LP + + L +S+N N+L +P E+C L+ L L LN N L
Sbjct: 108 NLILLNLNNNHLTQLPQE-VSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLI 166
Query: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL 158
+P L L+ L L+ N +G LP +LC L+ L ++D++ N I+ P +L++ E
Sbjct: 167 CIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREF 226
Query: 159 NLNQNQI 165
N +
Sbjct: 227 YCEGNPL 233
Score = 72.8 bits (177), Expect = 2e-13
Identities = 46/133 (34%), Positives = 72/133 (54%), Gaps = 1/133 (0%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L E P +++ LTS L+ + LS N+I P L L+LNNN LT LP E+ LK
Sbjct: 72 LEEVPEEMKYLTS-LKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLK 130
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
L +S+N N L +P L L L L+ NQL +P ++ L+ L + L++N I
Sbjct: 131 SLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGV 190
Query: 146 IPDSVGELQVIEL 158
+P+ + +L+ + +
Sbjct: 191 LPEELCDLKKLRI 203
Score = 58.2 bits (139), Expect = 6e-09
Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Query: 85 KKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIR 144
K + ++LN + ++PS G+L LKTL L N + + P+LC+L L ++L N +
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 145 SIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQI 203
+P+ + L ++ L+L+ N+I + + +C ++ L N L+ LPQ + +
Sbjct: 74 EVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGLQNLILLNLNNNHLTQLPQEVSRLKSL 132
Query: 204 CLLAVEGN 211
+++ N
Sbjct: 133 TYMSINYN 140
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 91.3 bits (225), Expect = 7e-19
Identities = 56/196 (28%), Positives = 96/196 (48%), Gaps = 24/196 (12%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
V L+ P + +L +L +D+S+N++ +L ++ L+ L+L++N+L L
Sbjct: 91 VLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL 150
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMD 137
P ++ L LE L ++ N L LP + LS L+TL + NQL A P QL L L+ +D
Sbjct: 151 PAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELD 210
Query: 138 LSKNQIRSIPDSVGELQVIE------------------------LNLNQNQISQISVKIS 173
+S N++R +P+ + L+ ++ L L+ N + + + S
Sbjct: 211 VSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFS 270
Query: 174 CCPRLKILRLEENCLE 189
C RLK+L L N E
Sbjct: 271 CLQRLKMLNLSSNLFE 286
Score = 85.9 bits (211), Expect = 3e-17
Identities = 61/193 (31%), Positives = 100/193 (51%), Gaps = 4/193 (2%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L + GL E P L +LR + L N+ LPP + L L +++N+LT L E
Sbjct: 70 LGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAE 129
Query: 81 ICN-LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLS 139
+ + L++L L+L++N L LP+ G L+ L+ L +S N+L LP L L L +D+
Sbjct: 130 VVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVD 189
Query: 140 KNQIRSIPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
NQ+ + P + +L + EL+++ N++ + IS LKIL L + EL LP
Sbjct: 190 HNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL--SGAELGTLPAGFC 247
Query: 199 SDSQICLLAVEGN 211
+ + L ++ N
Sbjct: 248 ELASLESLMLDNN 260
Score = 79.0 bits (193), Expect = 3e-15
Identities = 63/187 (33%), Positives = 91/187 (48%), Gaps = 26/187 (13%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
LT FP L +L + L +D+S+N++ LP I LK L L+ +L LP C L
Sbjct: 193 LTAFPRQLLQLVA-LEELDVSSNRLRGLPED-ISALRALKILWLSGAELGTLPAGFCELA 250
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQ--- 142
LE+L L+NN L+ LP+ F L LK L+LS N P L L L+ + LS+NQ
Sbjct: 251 SLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTS 310
Query: 143 --------------------IRSIPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKIL 181
IR +PDS+ EL + EL L NQI+ + R+ +
Sbjct: 311 VPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLW 370
Query: 182 RLEENCL 188
++++N L
Sbjct: 371 KIKDNPL 377
Score = 70.5 bits (171), Expect = 1e-12
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 4/161 (2%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L + GL PA L L+ ++LS+N E P L+ L+ L L+ N+LT +P
Sbjct: 257 LDNNGLQALPAQFSCL-QRLKMLNLSSNLFEEFPAALL-PLAGLEELYLSRNQLTSVPSL 314
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
I L +L TL L+NN +R LP + +L+ L+ L L GNQ+ LP L + + +
Sbjct: 315 ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKD 374
Query: 141 NQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKIL 181
N + P V + + Q +++ + PRLK+L
Sbjct: 375 NPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQ--PRLKLL 413
Score = 58.9 bits (141), Expect = 4e-09
Identities = 46/150 (30%), Positives = 75/150 (50%), Gaps = 32/150 (21%)
Query: 76 VLPDEICNLKKLETLSLNNNHLRELPSTFGQ-LSALKTLSLSGNQLGALPPQLCSLRH-- 132
VLP NL +E L+L NN L E+P G L +L+ L L N+ LPP + L H
Sbjct: 57 VLP---ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 133 --LDV---------------------MDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQI 168
LDV ++LS NQ+ ++P +G L + EL+++ N+++ +
Sbjct: 114 TELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
Query: 169 SVKISCCPRLKILRLEENCLELSMLPQSIL 198
+SC RL+ L ++ N +L+ P+ +L
Sbjct: 174 PDSLSCLSRLRTLDVDHN--QLTAFPRQLL 201
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 89.4 bits (220), Expect = 3e-18
Identities = 69/213 (32%), Positives = 114/213 (53%), Gaps = 13/213 (6%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L+ P +L S L + L++ +++LP +G L +L L N L LP + L
Sbjct: 117 LSRLPDGFTQLRS-LAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLV 174
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
KLE L L N L LP T G L L+ L L NQL ALPP+L +LR L +D+S+N++
Sbjct: 175 KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 146 IPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKILRLEENCL--------ELSMLPQS 196
+P +G L ++ +L L+QN + ++ I +L IL++++N L + L +
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 197 ILSDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
IL+++ L+A+ +L ++ KL L ++E
Sbjct: 295 ILTEN--LLMALPRSLGKLTKLTNLNVDRNHLE 325
Score = 80.5 bits (197), Expect = 1e-15
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 24/187 (12%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLL-------------------KS 66
L E P +L NLR + LS+N+I+ LPP + L+ K+
Sbjct: 48 LRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKA 106
Query: 67 LSL---NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGAL 123
L + + N L+ LPD L+ L L+LN+ L+ LP G L+ L TL L N L +L
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSL 166
Query: 124 PPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILR 182
P L L L+ +DL N + +PD++G L + EL L++NQ+S + ++ RL L
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 183 LEENCLE 189
+ EN LE
Sbjct: 227 VSENRLE 233
Score = 73.6 bits (179), Expect = 1e-13
Identities = 56/183 (30%), Positives = 82/183 (44%), Gaps = 23/183 (12%)
Query: 4 SALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLL------ 57
SAL + ++ + + L E PA+L L L + LS N + LP +
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEELPAELGGLVL-LTDLLLSQNLLRRLPDGIGQLKQL 268
Query: 58 ----------------IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELP 101
IG L L L N L LP + L KL L+++ NHL LP
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Query: 102 STFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLN 161
G AL LSL N+L LPP+L L V+D++ N+++S+P ++ L + L L
Sbjct: 329 PEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLA 388
Query: 162 QNQ 164
+NQ
Sbjct: 389 ENQ 391
Score = 65.9 bits (159), Expect = 3e-11
Identities = 46/153 (30%), Positives = 82/153 (53%), Gaps = 4/153 (2%)
Query: 64 LKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGA 122
++S+ + L +P+EI + LE L L+ N LRELP F +L L+ L LS N++
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
Query: 123 LPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL-NLNQNQISQISVKISCCPRLKIL 181
LPP++ + L +D+S+N I IP+S+ + +E+ + + N +S++ + L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 182 RLEENCLELSMLPQSILSDSQICLLAVEGNLFE 214
L N + L LP + + + + L + NL +
Sbjct: 134 AL--NDVSLQALPGDVGNLANLVTLELRENLLK 164
Score = 60.5 bits (145), Expect = 1e-09
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 3/184 (1%)
Query: 33 LQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSL 92
L + ++ ++D + ++++P + L+ L L+ N+L LP L L L L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGL 66
Query: 93 NNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGE 152
++N ++ LP L L +S N + +P + + L++ D S N + +PD +
Sbjct: 67 SDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ 126
Query: 153 LQ-VIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
L+ + L LN + + + L L L EN L+ LP S+ ++ L + GN
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGN 184
Query: 212 LFEI 215
E+
Sbjct: 185 DLEV 188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 89.4 bits (220), Expect = 3e-18
Identities = 69/213 (32%), Positives = 114/213 (53%), Gaps = 13/213 (6%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L+ P +L S L + L++ +++LP +G L +L L N L LP + L
Sbjct: 117 LSRLPDGFTQLRS-LAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLV 174
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
KLE L L N L LP T G L L+ L L NQL ALPP+L +LR L +D+S+N++
Sbjct: 175 KLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Query: 146 IPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKILRLEENCL--------ELSMLPQS 196
+P +G L ++ +L L+QN + ++ I +L IL++++N L + L +
Sbjct: 235 LPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSEL 294
Query: 197 ILSDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
IL+++ L+A+ +L ++ KL L ++E
Sbjct: 295 ILTEN--LLMALPRSLGKLTKLTNLNVDRNHLE 325
Score = 80.5 bits (197), Expect = 1e-15
Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 24/187 (12%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLL-------------------KS 66
L E P +L NLR + LS+N+I+ LPP + L+ K+
Sbjct: 48 LRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKA 106
Query: 67 LSL---NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGAL 123
L + + N L+ LPD L+ L L+LN+ L+ LP G L+ L TL L N L +L
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSL 166
Query: 124 PPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILR 182
P L L L+ +DL N + +PD++G L + EL L++NQ+S + ++ RL L
Sbjct: 167 PASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLD 226
Query: 183 LEENCLE 189
+ EN LE
Sbjct: 227 VSENRLE 233
Score = 73.6 bits (179), Expect = 1e-13
Identities = 56/183 (30%), Positives = 82/183 (44%), Gaps = 23/183 (12%)
Query: 4 SALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLL------ 57
SAL + ++ + + L E PA+L L L + LS N + LP +
Sbjct: 210 SALPPELGNLRRLVCLDVSENRLEELPAELGGLVL-LTDLLLSQNLLRRLPDGIGQLKQL 268
Query: 58 ----------------IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELP 101
IG L L L N L LP + L KL L+++ NHL LP
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALP 328
Query: 102 STFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLN 161
G AL LSL N+L LPP+L L V+D++ N+++S+P ++ L + L L
Sbjct: 329 PEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLA 388
Query: 162 QNQ 164
+NQ
Sbjct: 389 ENQ 391
Score = 65.9 bits (159), Expect = 3e-11
Identities = 46/153 (30%), Positives = 82/153 (53%), Gaps = 4/153 (2%)
Query: 64 LKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGA 122
++S+ + L +P+EI + LE L L+ N LRELP F +L L+ L LS N++
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
Query: 123 LPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL-NLNQNQISQISVKISCCPRLKIL 181
LPP++ + L +D+S+N I IP+S+ + +E+ + + N +S++ + L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 182 RLEENCLELSMLPQSILSDSQICLLAVEGNLFE 214
L N + L LP + + + + L + NL +
Sbjct: 134 AL--NDVSLQALPGDVGNLANLVTLELRENLLK 164
Score = 60.5 bits (145), Expect = 1e-09
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 3/184 (1%)
Query: 33 LQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSL 92
L + ++ ++D + ++++P + L+ L L+ N+L LP L L L L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGL 66
Query: 93 NNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGE 152
++N ++ LP L L +S N + +P + + L++ D S N + +PD +
Sbjct: 67 SDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQ 126
Query: 153 LQ-VIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
L+ + L LN + + + L L L EN L+ LP S+ ++ L + GN
Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLK--SLPASLSFLVKLEQLDLGGN 184
Query: 212 LFEI 215
E+
Sbjct: 185 DLEV 188
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 88.6 bits (218), Expect = 4e-18
Identities = 75/239 (31%), Positives = 118/239 (49%), Gaps = 15/239 (6%)
Query: 3 NSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFT 62
NS + + V L LTE P +L+ N+ ++LS+N I+++P L T
Sbjct: 93 NSGVPDDIFKLDDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLT 151
Query: 63 LLKSLSLNNNKLTVLPDEICNLKKLETLSLNNN-----HLRELPSTFGQLSALKTLSLSG 117
L L L+ N+L LP ++ L L+TL LN N LR+LP+ ++AL+TL L
Sbjct: 152 DLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRS 207
Query: 118 NQ--LGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-ELNLNQNQISQISVKISC 174
Q LP L L +L +DLS N + +P+ + L + LNL+ NQI+++S+ I
Sbjct: 208 TQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQ 267
Query: 175 CPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLRELEGYDKYMERFTA 233
++ L L N +L+ LP +I S++ L + N + L G +E F A
Sbjct: 268 WVHVETLNLSRN--QLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
Score = 70.5 bits (171), Expect = 1e-12
Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 9/189 (4%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L + PA T +LR S + +S P + + L + L+ N LT +P+ + L
Sbjct: 191 LRQLPAMTALQTLHLR----STQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLP 246
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI-- 143
L L+L++N + EL Q ++TL+LS NQL +LP +C L L + L+ N++
Sbjct: 247 SLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDF 306
Query: 144 RSIPDSVGELQVIELNLNQNQISQISVKISC-CPRLKILRLEENCLELSMLPQSILSDSQ 202
+P +G+L +E + N ++ + C CP+L+ L L +N L LP++I ++
Sbjct: 307 DGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKN--HLVTLPEAIHFLTE 364
Query: 203 ICLLAVEGN 211
I +L V N
Sbjct: 365 IEVLDVREN 373
Score = 69.3 bits (168), Expect = 3e-12
Identities = 59/187 (31%), Positives = 90/187 (48%), Gaps = 7/187 (3%)
Query: 40 LRTIDLSNNKIES-LPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
+R +DLS N + P + T L+ L LN L LP+E+ L+KLE LS+++N+L
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
Query: 99 ELPSTFGQLSALKTLSLSGNQL--GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQ-V 155
L L +L+ + N L +P + L L V+DLS NQ+ P + + +
Sbjct: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
Query: 156 IELNLNQNQISQISVKISC-CPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFE 214
+ LNL+ N I I ++ L L L EN LE LP + + L + GN
Sbjct: 130 LVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE--SLPPQMRRLVHLQTLVLNGNPLL 187
Query: 215 IKKLREL 221
+LR+L
Sbjct: 188 HAQLRQL 194
Score = 60.1 bits (144), Expect = 2e-09
Identities = 41/119 (34%), Positives = 60/119 (50%), Gaps = 8/119 (6%)
Query: 9 HVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIE-SLPPLLIGKFTLLKSL 67
HVET L LT P+ + KL S L+ + L++NK++ P IGK T L+
Sbjct: 270 HVET------LNLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 68 SLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQ 126
NN L ++P+ +C KL L LN NHL LP L+ ++ L + N +PP+
Sbjct: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPK 381
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 87.8 bits (216), Expect = 7e-18
Identities = 64/208 (30%), Positives = 105/208 (50%), Gaps = 10/208 (4%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
LK FP +L L + L IDL NKI ++P IG T L+ + +N L VLP
Sbjct: 172 LKRNQFEVFPQELCVLYT-LEIIDLDENKIGAIPEE-IGHLTGLQKFYMASNNLPVLPAS 229
Query: 81 ICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK 140
+C +L L L++N L +P +F +L + + LSGN+L +P +C L ++ L
Sbjct: 230 LCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGN 289
Query: 141 NQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILS 199
+ + S L + L+L+QN + ++I L++L L++N ++ LP + S
Sbjct: 290 TGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDN--KIGQLPSELGS 347
Query: 200 DSQICLLAVEGNLF-----EIKKLRELE 222
S++ +L + GN F E+ L LE
Sbjct: 348 LSKLKILGLTGNEFLSFPEEVLSLASLE 375
Score = 87.0 bits (214), Expect = 1e-17
Identities = 64/208 (30%), Positives = 104/208 (50%), Gaps = 32/208 (15%)
Query: 31 ADLQKLTSNLRTIDLSNNKIESLPPLLI-------------------GKFTLL---KSLS 68
A+L+K+T I LS N++E +P L+ G F L + L
Sbjct: 254 AELRKMTE----IGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLD 309
Query: 69 LNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLC 128
L+ N L P +IC LK LE L L++N + +LPS G LS LK L L+GN+ + P ++
Sbjct: 310 LSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVL 369
Query: 129 SLRHLDVMDLSKNQ---IRSIPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKILRLE 184
SL L+ + + ++Q + +P+ + +LQ + EL + N + + V + P L++L
Sbjct: 370 SLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCR 429
Query: 185 ENCLELSMLPQSILSDSQICLLAVEGNL 212
N L+ LP +I + L +E NL
Sbjct: 430 HNLLK--QLPDAICQAQALKELRLEDNL 455
Score = 78.6 bits (192), Expect = 5e-15
Identities = 60/208 (28%), Positives = 99/208 (47%), Gaps = 6/208 (2%)
Query: 11 ETAQKTGV--FQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS 68
E TG+ F + L PA L + S L +DLS+N + S+P + + +
Sbjct: 206 EIGHLTGLQKFYMASNNLPVLPASLCQC-SQLSVLDLSHNLLHSIPKSF-AELRKMTEIG 263
Query: 69 LNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLC 128
L+ N+L +P IC L L L N L L +F L L+ L LS N L P Q+C
Sbjct: 264 LSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC 323
Query: 129 SLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRL-EEN 186
+L++L+V+ L N+I +P +G L ++ L L N+ ++ L+ L + ++
Sbjct: 324 ALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQ 383
Query: 187 CLELSMLPQSILSDSQICLLAVEGNLFE 214
+L+ +P+ I + L +E N E
Sbjct: 384 GFKLTYVPEHIRKLQSLKELYIENNHLE 411
Score = 70.9 bits (172), Expect = 9e-13
Identities = 64/245 (26%), Positives = 110/245 (44%), Gaps = 56/245 (22%)
Query: 32 DLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLS 91
D Q + ID SN + ++P L I FT L+ + L NN++ +P EI LK + L
Sbjct: 19 DPQHVNDRTFFIDASNQSLTAIP-LEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLY 77
Query: 92 LNNNHLRELPSTFGQLSALKTLSLSGN------------------------QLGALPPQL 127
L+ N+LR L G LS+L++L LS N L +P +
Sbjct: 78 LDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI 137
Query: 128 C-SLRHLDVMDLSKNQIRSIP-DSVGELQVIELNLNQNQISQISVKISCCPRLKILRLEE 185
+L HL+++ L+ N ++ +P + V + ++ E+ L +NQ ++ L+I+ L+E
Sbjct: 138 FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDE 197
Query: 186 NCL---------------------ELSMLPQSILSDSQICLLAVEGNLF--------EIK 216
N + L +LP S+ SQ+ +L + NL E++
Sbjct: 198 NKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELR 257
Query: 217 KLREL 221
K+ E+
Sbjct: 258 KMTEI 262
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/146 (30%), Positives = 73/146 (50%), Gaps = 6/146 (4%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNN--KLT 75
V L D + + P++L L S L+ + L+ N+ S P ++ +L K + KLT
Sbjct: 330 VLGLDDNKIGQLPSELGSL-SKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLT 388
Query: 76 VLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDV 135
+P+ I L+ L+ L + NNHL LP + G + L+ L N L LP +C + L
Sbjct: 389 YVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKE 448
Query: 136 MDLSKNQIRSIP---DSVGELQVIEL 158
+ L N + +P DS+ L+V+ L
Sbjct: 449 LRLEDNLLTHLPENLDSLVNLKVLTL 474
Score = 59.7 bits (143), Expect = 2e-09
Identities = 39/110 (35%), Positives = 59/110 (53%), Gaps = 4/110 (3%)
Query: 22 KDRG--LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPD 79
+D+G LT P ++KL S L+ + + NN +E LP + +G L+ L +N L LPD
Sbjct: 381 QDQGFKLTYVPEHIRKLQS-LKELYIENNHLEYLP-VSLGSMPNLEVLDCRHNLLKQLPD 438
Query: 80 EICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS 129
IC + L+ L L +N L LP L LK L+L N + P ++C+
Sbjct: 439 AICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCA 488
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 87.0 bits (214), Expect = 1e-17
Identities = 50/176 (28%), Positives = 99/176 (56%), Gaps = 3/176 (1%)
Query: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
NL+ + LS+N ++ LP IG + +L ++ N+L LPD I L +E L + N +
Sbjct: 254 NLQDLLLSSNSLQQLPET-IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVE 312
Query: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE- 157
LPS+ GQL+ L+T + N L LPP++ S +++ V+ L N++ ++P+ +G++Q ++
Sbjct: 313 ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Query: 158 LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF 213
+NL+ N++ + + +L + L +N ++P +DS+ + + +F
Sbjct: 373 INLSDNRLKNLPFSFTKLQQLTAMWLSDN-QSKPLIPLQKETDSETQKMVLTNYMF 427
Score = 82.0 bits (201), Expect = 4e-16
Identities = 58/196 (29%), Positives = 92/196 (46%), Gaps = 26/196 (13%)
Query: 25 GLTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------PLLIGKFT 62
G+ EFP ++ K L ++ S N I LP P G+ T
Sbjct: 103 GIQEFPENI-KNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT 161
Query: 63 LLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGA 122
L+ L L N+L +LP + L +LE L L +N E+P QLS LK + N+L
Sbjct: 162 KLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTF 221
Query: 123 LPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKIL 181
+P + SL+ L +D+SKN I + + + + + +L L+ N + Q+ I + L
Sbjct: 222 IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTL 281
Query: 182 RLEENCLELSMLPQSI 197
+++EN +L LP SI
Sbjct: 282 KIDEN--QLMYLPDSI 295
Score = 79.3 bits (194), Expect = 3e-15
Identities = 60/244 (24%), Positives = 112/244 (45%), Gaps = 31/244 (12%)
Query: 6 LRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLL-------- 57
L A+ K + +L++ L P + +LT L +DL +N+ +P +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ-LERLDLGSNEFTEVPEVLEQLSGLKE 211
Query: 58 --------------IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPST 103
IG L L ++ N + ++ + I + L+ L L++N L++LP T
Sbjct: 212 FWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPET 271
Query: 104 FGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQ 162
G L + TL + NQL LP + L ++ +D S N++ ++P S+G+L + +
Sbjct: 272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADH 331
Query: 163 NQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNL-----FEIKK 217
N + Q+ +I + +L L N LE LP+ + ++ ++ + N F K
Sbjct: 332 NYLQQLPPEIGSWKNITVLFLHSNKLE--TLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Query: 218 LREL 221
L++L
Sbjct: 390 LQQL 393
Score = 74.7 bits (182), Expect = 7e-14
Identities = 54/189 (28%), Positives = 98/189 (51%), Gaps = 5/189 (2%)
Query: 42 TIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELP 101
T+D S+ +E +P + L+ L L+ N++ LP ++ N + L LSL +N L LP
Sbjct: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLP 85
Query: 102 STFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGE-LQVIELNL 160
++ L L+ L +S N + P + + + L +++ S N I +PD + L + +L L
Sbjct: 86 ASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
Query: 161 NQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-EIKK-L 218
N + + +L+IL L EN +L MLP+++ +Q+ L + N F E+ + L
Sbjct: 146 NDAFLEFLPANFGRLTKLQILELREN--QLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 219 RELEGYDKY 227
+L G ++
Sbjct: 204 EQLSGLKEF 212
Score = 70.1 bits (170), Expect = 2e-12
Identities = 66/256 (25%), Positives = 101/256 (39%), Gaps = 73/256 (28%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L + P ++ L + L N+IE LP L +L K LSL +N LT LP I NL
Sbjct: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHK-LSLPDNDLTTLPASIANLI 92
Query: 86 KLETLSLNNNHLRE---------------------------------------------- 99
L L ++ N ++E
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL------ 153
LP+ FG+L+ L+ L L NQL LP + L L+ +DL N+ +P+ + +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 154 ------------------QVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQ 195
Q+ L++++N I + IS C L+ L L N L+ LP+
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ--QLPE 270
Query: 196 SILSDSQICLLAVEGN 211
+I S I L ++ N
Sbjct: 271 TIGSLKNITTLKIDEN 286
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 87.0 bits (214), Expect = 1e-17
Identities = 50/176 (28%), Positives = 99/176 (56%), Gaps = 3/176 (1%)
Query: 39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
NL+ + LS+N ++ LP IG + +L ++ N+L LPD I L +E L + N +
Sbjct: 254 NLQDLLLSSNSLQQLPET-IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVE 312
Query: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE- 157
LPS+ GQL+ L+T + N L LPP++ S +++ V+ L N++ ++P+ +G++Q ++
Sbjct: 313 ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKV 372
Query: 158 LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF 213
+NL+ N++ + + +L + L +N ++P +DS+ + + +F
Sbjct: 373 INLSDNRLKNLPFSFTKLQQLTAMWLSDN-QSKPLIPLQKETDSETQKMVLTNYMF 427
Score = 82.0 bits (201), Expect = 4e-16
Identities = 58/196 (29%), Positives = 92/196 (46%), Gaps = 26/196 (13%)
Query: 25 GLTEFPADLQKLTSNLRTIDLSNNKIESLP----------------------PLLIGKFT 62
G+ EFP ++ K L ++ S N I LP P G+ T
Sbjct: 103 GIQEFPENI-KNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLT 161
Query: 63 LLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGA 122
L+ L L N+L +LP + L +LE L L +N E+P QLS LK + N+L
Sbjct: 162 KLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTF 221
Query: 123 LPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-ELNLNQNQISQISVKISCCPRLKIL 181
+P + SL+ L +D+SKN I + + + + + +L L+ N + Q+ I + L
Sbjct: 222 IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTL 281
Query: 182 RLEENCLELSMLPQSI 197
+++EN +L LP SI
Sbjct: 282 KIDEN--QLMYLPDSI 295
Score = 79.3 bits (194), Expect = 3e-15
Identities = 60/244 (24%), Positives = 112/244 (45%), Gaps = 31/244 (12%)
Query: 6 LRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLL-------- 57
L A+ K + +L++ L P + +LT L +DL +N+ +P +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ-LERLDLGSNEFTEVPEVLEQLSGLKE 211
Query: 58 --------------IGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPST 103
IG L L ++ N + ++ + I + L+ L L++N L++LP T
Sbjct: 212 FWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPET 271
Query: 104 FGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQ 162
G L + TL + NQL LP + L ++ +D S N++ ++P S+G+L + +
Sbjct: 272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADH 331
Query: 163 NQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNL-----FEIKK 217
N + Q+ +I + +L L N LE LP+ + ++ ++ + N F K
Sbjct: 332 NYLQQLPPEIGSWKNITVLFLHSNKLE--TLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Query: 218 LREL 221
L++L
Sbjct: 390 LQQL 393
Score = 74.7 bits (182), Expect = 7e-14
Identities = 54/189 (28%), Positives = 98/189 (51%), Gaps = 5/189 (2%)
Query: 42 TIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELP 101
T+D S+ +E +P + L+ L L+ N++ LP ++ N + L LSL +N L LP
Sbjct: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLP 85
Query: 102 STFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGE-LQVIELNL 160
++ L L+ L +S N + P + + + L +++ S N I +PD + L + +L L
Sbjct: 86 ASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
Query: 161 NQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-EIKK-L 218
N + + +L+IL L EN +L MLP+++ +Q+ L + N F E+ + L
Sbjct: 146 NDAFLEFLPANFGRLTKLQILELREN--QLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 219 RELEGYDKY 227
+L G ++
Sbjct: 204 EQLSGLKEF 212
Score = 70.1 bits (170), Expect = 2e-12
Identities = 66/256 (25%), Positives = 101/256 (39%), Gaps = 73/256 (28%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L + P ++ L + L N+IE LP L +L K LSL +N LT LP I NL
Sbjct: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHK-LSLPDNDLTTLPASIANLI 92
Query: 86 KLETLSLNNNHLRE---------------------------------------------- 99
L L ++ N ++E
Sbjct: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
Query: 100 LPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL------ 153
LP+ FG+L+ L+ L L NQL LP + L L+ +DL N+ +P+ + +L
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 154 ------------------QVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQ 195
Q+ L++++N I + IS C L+ L L N L+ LP+
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ--QLPE 270
Query: 196 SILSDSQICLLAVEGN 211
+I S I L ++ N
Sbjct: 271 TIGSLKNITTLKIDEN 286
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 86.7 bits (213), Expect = 2e-17
Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 25/166 (15%)
Query: 39 NLRTIDLSNNKIESLP------------------------PLLIGKFTLLKSLSLNNNKL 74
NL+ IDL +N ++++ P+ IG T L+ L LN NK+
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 75 TVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLD 134
+P ++ +KL L L++N+L LP+ G L L+ L+++ N++ LPP+L R L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 135 VMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLK 179
+ L N ++S+P VGEL + ++ L N++ + V++ CP LK
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 60.1 bits (144), Expect = 2e-09
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 23/198 (11%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNN--KLTVLPD--EICNLKKLETLSLNNN 95
L+ + L +N + LP ++ L+ LS+NN KL VL ++ NL +LE + +
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD-- 602
Query: 96 HLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK---NQIRSIPDSVGE 152
L +P + L L+ + L N L + ++ S +HL + K N I IP +G
Sbjct: 603 -LERIPHSIFSLHNLQEIDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 153 LQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
L +E L LN+N+I +I ++ C +L+ L L N L+ LP I + LA+ N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN--NLTFLPADIGLLQNLQNLAITAN 718
Query: 212 --------LFEIKKLREL 221
LF+ +KLR L
Sbjct: 719 RIETLPPELFQCRKLRAL 736
Score = 56.2 bits (134), Expect = 2e-08
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 4/116 (3%)
Query: 14 QKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNK 73
+K L LT PAD+ L NL+ + ++ N+IE+LPP L + L++L L NN
Sbjct: 685 RKLRYLDLSHNNLTFLPADIG-LLQNLQNLAITANRIETLPPELF-QCRKLRALHLGNNV 742
Query: 74 LTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKT--LSLSGNQLGALPPQL 127
L LP + L L + L N L LP G+ LK L + + LPP++
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 36.2 bits (82), Expect = 0.026
Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 19/206 (9%)
Query: 43 IDLSNNKIESLP----PLLIGKFTLLKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHL 97
++L K+E +P P I + T LK L L + + + L++ L L + +
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505
Query: 98 RELPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKN--QIRSIPDSV 150
+E+P L L+ L L+GN + L L+ L V+ L N ++ + V
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565
Query: 151 G-ELQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVE 209
G LQ + +N N+ +++ V S + LE +L +P SI S + + ++
Sbjct: 566 GVHLQKLSIN---NEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLK 622
Query: 210 GNLFEIKKLRELEGYDKYMERFTATK 235
N +K + E+ + +++ R T K
Sbjct: 623 DN--NLKTIEEIISF-QHLHRLTCLK 645
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 86.7 bits (213), Expect = 2e-17
Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 25/166 (15%)
Query: 39 NLRTIDLSNNKIESLP------------------------PLLIGKFTLLKSLSLNNNKL 74
NL+ IDL +N ++++ P+ IG T L+ L LN NK+
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 75 TVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLD 134
+P ++ +KL L L++N+L LP+ G L L+ L+++ N++ LPP+L R L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 135 VMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLK 179
+ L N ++S+P VGEL + ++ L N++ + V++ CP LK
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 60.1 bits (144), Expect = 2e-09
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 23/198 (11%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNN--KLTVLPD--EICNLKKLETLSLNNN 95
L+ + L +N + LP ++ L+ LS+NN KL VL ++ NL +LE + +
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD-- 602
Query: 96 HLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK---NQIRSIPDSVGE 152
L +P + L L+ + L N L + ++ S +HL + K N I IP +G
Sbjct: 603 -LERIPHSIFSLHNLQEIDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 153 LQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
L +E L LN+N+I +I ++ C +L+ L L N L+ LP I + LA+ N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN--NLTFLPADIGLLQNLQNLAITAN 718
Query: 212 --------LFEIKKLREL 221
LF+ +KLR L
Sbjct: 719 RIETLPPELFQCRKLRAL 736
Score = 56.2 bits (134), Expect = 2e-08
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 4/116 (3%)
Query: 14 QKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNK 73
+K L LT PAD+ L NL+ + ++ N+IE+LPP L + L++L L NN
Sbjct: 685 RKLRYLDLSHNNLTFLPADIG-LLQNLQNLAITANRIETLPPELF-QCRKLRALHLGNNV 742
Query: 74 LTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKT--LSLSGNQLGALPPQL 127
L LP + L L + L N L LP G+ LK L + + LPP++
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 36.2 bits (82), Expect = 0.026
Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 19/206 (9%)
Query: 43 IDLSNNKIESLP----PLLIGKFTLLKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHL 97
++L K+E +P P I + T LK L L + + + L++ L L + +
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505
Query: 98 RELPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKN--QIRSIPDSV 150
+E+P L L+ L L+GN + L L+ L V+ L N ++ + V
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565
Query: 151 G-ELQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVE 209
G LQ + +N N+ +++ V S + LE +L +P SI S + + ++
Sbjct: 566 GVHLQKLSIN---NEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLK 622
Query: 210 GNLFEIKKLRELEGYDKYMERFTATK 235
N +K + E+ + +++ R T K
Sbjct: 623 DN--NLKTIEEIISF-QHLHRLTCLK 645
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 86.7 bits (213), Expect = 2e-17
Identities = 51/166 (30%), Positives = 87/166 (52%), Gaps = 25/166 (15%)
Query: 39 NLRTIDLSNNKIESLP------------------------PLLIGKFTLLKSLSLNNNKL 74
NL+ IDL +N ++++ P+ IG T L+ L LN NK+
Sbjct: 615 NLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKI 674
Query: 75 TVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLD 134
+P ++ +KL L L++N+L LP+ G L L+ L+++ N++ LPP+L R L
Sbjct: 675 EKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 135 VMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLK 179
+ L N ++S+P VGEL + ++ L N++ + V++ CP LK
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 60.1 bits (144), Expect = 2e-09
Identities = 60/198 (30%), Positives = 96/198 (48%), Gaps = 23/198 (11%)
Query: 40 LRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNN--KLTVLPD--EICNLKKLETLSLNNN 95
L+ + L +N + LP ++ L+ LS+NN KL VL ++ NL +LE + +
Sbjct: 546 LKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCD-- 602
Query: 96 HLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSK---NQIRSIPDSVGE 152
L +P + L L+ + L N L + ++ S +HL + K N I IP +G
Sbjct: 603 -LERIPHSIFSLHNLQEIDLKDNNLKTIE-EIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 153 LQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
L +E L LN+N+I +I ++ C +L+ L L N L+ LP I + LA+ N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN--NLTFLPADIGLLQNLQNLAITAN 718
Query: 212 --------LFEIKKLREL 221
LF+ +KLR L
Sbjct: 719 RIETLPPELFQCRKLRAL 736
Score = 56.2 bits (134), Expect = 2e-08
Identities = 39/116 (33%), Positives = 57/116 (49%), Gaps = 4/116 (3%)
Query: 14 QKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNK 73
+K L LT PAD+ L NL+ + ++ N+IE+LPP L + L++L L NN
Sbjct: 685 RKLRYLDLSHNNLTFLPADIG-LLQNLQNLAITANRIETLPPELF-QCRKLRALHLGNNV 742
Query: 74 LTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKT--LSLSGNQLGALPPQL 127
L LP + L L + L N L LP G+ LK L + + LPP++
Sbjct: 743 LQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 36.2 bits (82), Expect = 0.026
Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 19/206 (9%)
Query: 43 IDLSNNKIESLP----PLLIGKFTLLKSLSLNNNKLTVLPDEICNLKK-LETLSLNNNHL 97
++L K+E +P P I + T LK L L + + + L++ L L + +
Sbjct: 446 VELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDI 505
Query: 98 RELPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKN--QIRSIPDSV 150
+E+P L L+ L L+GN + L L+ L V+ L N ++ + V
Sbjct: 506 KEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDV 565
Query: 151 G-ELQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVE 209
G LQ + +N N+ +++ V S + LE +L +P SI S + + ++
Sbjct: 566 GVHLQKLSIN---NEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLK 622
Query: 210 GNLFEIKKLRELEGYDKYMERFTATK 235
N +K + E+ + +++ R T K
Sbjct: 623 DN--NLKTIEEIISF-QHLHRLTCLK 645
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 85.1 bits (209), Expect = 5e-17
Identities = 60/174 (34%), Positives = 100/174 (57%), Gaps = 5/174 (2%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
LT PA L L ++L +DLS N +E+LP ++ + L +L L++N L+ LP+ + L
Sbjct: 114 LTNLPAGLSGL-AHLAHLDLSFNSLETLPACVL-QMRGLGALLLSHNCLSELPEALGALP 171
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
L L++ +N L+ LP G LS L+ L LS N L LPP++ L L ++L+ N+++S
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 146 IPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
+P S+ L+ + L L+ N ++ + ++ P L L L +N +L LP +L
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN--QLRDLPPELL 283
Score = 75.5 bits (184), Expect = 4e-14
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 2/145 (1%)
Query: 17 GVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTV 76
G L L+E P L L + L + +++N++++LPP L G + L+ L L+ N L
Sbjct: 151 GALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPAL-GALSTLQRLDLSQNLLDT 208
Query: 77 LPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVM 136
LP EI L L L+L +N L+ LP++ L +L+ L L N L ++P L L L +
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Query: 137 DLSKNQIRSIPDSVGELQVIELNLN 161
DL NQ+R +P + + + L N
Sbjct: 269 DLRDNQLRDLPPELLDAPFVRLQGN 293
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 85.1 bits (209), Expect = 5e-17
Identities = 60/174 (34%), Positives = 100/174 (57%), Gaps = 5/174 (2%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
LT PA L L ++L +DLS N +E+LP ++ + L +L L++N L+ LP+ + L
Sbjct: 114 LTNLPAGLSGL-AHLAHLDLSFNSLETLPACVL-QMRGLGALLLSHNCLSELPEALGALP 171
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRS 145
L L++ +N L+ LP G LS L+ L LS N L LPP++ L L ++L+ N+++S
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 146 IPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
+P S+ L+ + L L+ N ++ + ++ P L L L +N +L LP +L
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN--QLRDLPPELL 283
Score = 75.5 bits (184), Expect = 4e-14
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 2/145 (1%)
Query: 17 GVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTV 76
G L L+E P L L + L + +++N++++LPP L G + L+ L L+ N L
Sbjct: 151 GALLLSHNCLSELPEALGALPA-LTFLTVTHNRLQTLPPAL-GALSTLQRLDLSQNLLDT 208
Query: 77 LPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVM 136
LP EI L L L+L +N L+ LP++ L +L+ L L N L ++P L L L +
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Query: 137 DLSKNQIRSIPDSVGELQVIELNLN 161
DL NQ+R +P + + + L N
Sbjct: 269 DLRDNQLRDLPPELLDAPFVRLQGN 293
>gi|190014581 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 85.1 bits (209), Expect = 5e-17
Identities = 62/196 (31%), Positives = 108/196 (55%), Gaps = 6/196 (3%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
VF+L TE P L++ T +LR +SN I+ +P I F ++ L L N+++ L
Sbjct: 102 VFELSGEHWTELPDSLKEQT-HLREWYISNTLIQIIPTY-IQLFQAMRILDLPKNQISHL 159
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN-QLGALPPQLCSLRHLDVM 136
P EI LK L+ L++ N+L+ +P G L+ L SGN +L LP +L +L+ + +
Sbjct: 160 PAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFV 219
Query: 137 DLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQ 195
D+S N+ S+P V + ++ L+++ N ++ + I L+ L +N +L+ LP
Sbjct: 220 DISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKN--KLTYLPY 277
Query: 196 SILSDSQICLLAVEGN 211
S+L+ ++ LL V G+
Sbjct: 278 SMLNLKKLTLLVVSGD 293
Score = 57.8 bits (138), Expect = 8e-09
Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L E P +L L + +D+S NK S+P + + + + L+ L +++N LT LP +I L+
Sbjct: 203 LMELPFELSNL-KQVTFVDISANKFSSVP-ICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS----LRHLDVMD 137
+L++ L N L LP + L L L +SG+ L LP LC L+ + +MD
Sbjct: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMD 316
Score = 53.9 bits (128), Expect = 1e-07
Identities = 41/181 (22%), Positives = 88/181 (48%), Gaps = 9/181 (4%)
Query: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN 118
GK + L+ T LPD + L ++N ++ +P+ A++ L L N
Sbjct: 95 GKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKN 154
Query: 119 QLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQN-QISQISVKISCCP 176
Q+ LP ++ L++L +++ N ++SIP +G+ + +E L+ + N ++ ++ ++S
Sbjct: 155 QISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLK 214
Query: 177 RLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELEGYDKYMERF 231
++ + + N + S +P +L S + L + N +I +L EL+ + Y +
Sbjct: 215 QVTFVDISAN--KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
Query: 232 T 232
T
Sbjct: 273 T 273
Score = 50.4 bits (119), Expect = 1e-06
Identities = 40/166 (24%), Positives = 81/166 (48%), Gaps = 26/166 (15%)
Query: 9 HVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS 68
+++ Q + L ++ PA++ L NL+ +++ N ++S+PP L G L+ L
Sbjct: 139 YIQLFQAMRILDLPKNQISHLPAEIGCL-KNLKELNVGFNYLKSIPPEL-GDCENLERLD 196
Query: 69 LNNN-KLTVLPDEICNLKK-----------------------LETLSLNNNHLRELPSTF 104
+ N +L LP E+ NLK+ L+ L +++N+L +LP
Sbjct: 197 CSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDI 256
Query: 105 GQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
+L L++ L N+L LP + +L+ L ++ +S + + +P ++
Sbjct: 257 DRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 47.0 bits (110), Expect = 1e-05
Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 11/157 (7%)
Query: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
L K+E +L LP G+ S+ LSG LP L HL +S I
Sbjct: 76 LDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLI 133
Query: 144 RSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQ 202
+ IP + Q + L+L +NQIS + +I C LK L + N L+ +P +
Sbjct: 134 QIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK--SIPPELGDCEN 191
Query: 203 ICLLAVEGNL------FEIKKLRELEGYDKYMERFTA 233
+ L GNL FE+ L+++ D +F++
Sbjct: 192 LERLDCSGNLELMELPFELSNLKQVTFVDISANKFSS 228
>gi|27545328 leucine rich repeat containing 2 [Homo sapiens]
Length = 371
Score = 85.1 bits (209), Expect = 5e-17
Identities = 62/196 (31%), Positives = 108/196 (55%), Gaps = 6/196 (3%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
VF+L TE P L++ T +LR +SN I+ +P I F ++ L L N+++ L
Sbjct: 102 VFELSGEHWTELPDSLKEQT-HLREWYISNTLIQIIPTY-IQLFQAMRILDLPKNQISHL 159
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN-QLGALPPQLCSLRHLDVM 136
P EI LK L+ L++ N+L+ +P G L+ L SGN +L LP +L +L+ + +
Sbjct: 160 PAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFV 219
Query: 137 DLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQ 195
D+S N+ S+P V + ++ L+++ N ++ + I L+ L +N +L+ LP
Sbjct: 220 DISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKN--KLTYLPY 277
Query: 196 SILSDSQICLLAVEGN 211
S+L+ ++ LL V G+
Sbjct: 278 SMLNLKKLTLLVVSGD 293
Score = 57.8 bits (138), Expect = 8e-09
Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 6/116 (5%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLK 85
L E P +L L + +D+S NK S+P + + + + L+ L +++N LT LP +I L+
Sbjct: 203 LMELPFELSNL-KQVTFVDISANKFSSVP-ICVLRMSNLQWLDISSNNLTDLPQDIDRLE 260
Query: 86 KLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCS----LRHLDVMD 137
+L++ L N L LP + L L L +SG+ L LP LC L+ + +MD
Sbjct: 261 ELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMD 316
Score = 53.9 bits (128), Expect = 1e-07
Identities = 41/181 (22%), Positives = 88/181 (48%), Gaps = 9/181 (4%)
Query: 59 GKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGN 118
GK + L+ T LPD + L ++N ++ +P+ A++ L L N
Sbjct: 95 GKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLIQIIPTYIQLFQAMRILDLPKN 154
Query: 119 QLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQN-QISQISVKISCCP 176
Q+ LP ++ L++L +++ N ++SIP +G+ + +E L+ + N ++ ++ ++S
Sbjct: 155 QISHLPAEIGCLKNLKELNVGFNYLKSIPPELGDCENLERLDCSGNLELMELPFELSNLK 214
Query: 177 RLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLF-----EIKKLRELEGYDKYMERF 231
++ + + N + S +P +L S + L + N +I +L EL+ + Y +
Sbjct: 215 QVTFVDISAN--KFSSVPICVLRMSNLQWLDISSNNLTDLPQDIDRLEELQSFLLYKNKL 272
Query: 232 T 232
T
Sbjct: 273 T 273
Score = 50.4 bits (119), Expect = 1e-06
Identities = 40/166 (24%), Positives = 81/166 (48%), Gaps = 26/166 (15%)
Query: 9 HVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLS 68
+++ Q + L ++ PA++ L NL+ +++ N ++S+PP L G L+ L
Sbjct: 139 YIQLFQAMRILDLPKNQISHLPAEIGCL-KNLKELNVGFNYLKSIPPEL-GDCENLERLD 196
Query: 69 LNNN-KLTVLPDEICNLKK-----------------------LETLSLNNNHLRELPSTF 104
+ N +L LP E+ NLK+ L+ L +++N+L +LP
Sbjct: 197 CSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQWLDISSNNLTDLPQDI 256
Query: 105 GQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
+L L++ L N+L LP + +L+ L ++ +S + + +P ++
Sbjct: 257 DRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTAL 302
Score = 47.0 bits (110), Expect = 1e-05
Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 11/157 (7%)
Query: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
L K+E +L LP G+ S+ LSG LP L HL +S I
Sbjct: 76 LDKIERNTLTRQS--SLPKDRGKRSSAFVFELSGEHWTELPDSLKEQTHLREWYISNTLI 133
Query: 144 RSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQ 202
+ IP + Q + L+L +NQIS + +I C LK L + N L+ +P +
Sbjct: 134 QIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNVGFNYLK--SIPPELGDCEN 191
Query: 203 ICLLAVEGNL------FEIKKLRELEGYDKYMERFTA 233
+ L GNL FE+ L+++ D +F++
Sbjct: 192 LERLDCSGNLELMELPFELSNLKQVTFVDISANKFSS 228
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 85.1 bits (209), Expect = 5e-17
Identities = 64/203 (31%), Positives = 111/203 (54%), Gaps = 10/203 (4%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKL---TVLPDEIC 82
L P L +L+ +D+S N + +L P L+ L++L NN+L + LP +
Sbjct: 56 LVSLPRALGSGFPHLQLLDVSGNALTALGPELLA-LRGLRTLLAKNNRLGGPSALPKGLA 114
Query: 83 N---LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLS 139
+ L+ L+L+ N +E+P++ +L AL+TLSL GNQL ++P ++ +L+ L+ + L
Sbjct: 115 QSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLG 174
Query: 140 KNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
N I+ IP +G L + L L N+I I ++S L+ L L N L+ LP+ IL
Sbjct: 175 GNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNL--LTYLPREIL 232
Query: 199 SDSQICLLAVEGNLFEIKKLREL 221
+ + L++ GN ++ +R+L
Sbjct: 233 NLIHLEELSLRGNPLVVRFVRDL 255
Score = 75.1 bits (183), Expect = 5e-14
Identities = 48/143 (33%), Positives = 78/143 (54%), Gaps = 7/143 (4%)
Query: 24 RGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICN 83
+GL + P L +L+ ++LS N + +P L+ + L++LSL N+L +P EI N
Sbjct: 111 KGLAQSP-----LCRSLQVLNLSGNCFQEVPASLL-ELRALQTLSLGGNQLQSIPAEIEN 164
Query: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI 143
L+ LE L L N ++E+P G L +L L L N++ ++PPQL L L + L N +
Sbjct: 165 LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLL 224
Query: 144 RSIPDSVGEL-QVIELNLNQNQI 165
+P + L + EL+L N +
Sbjct: 225 TYLPREILNLIHLEELSLRGNPL 247
Score = 43.1 bits (100), Expect = 2e-04
Identities = 49/171 (28%), Positives = 74/171 (43%), Gaps = 41/171 (23%)
Query: 90 LSLNNNHLRELPSTFGQ-LSALKTLSLSGNQLGALPPQLCSL------------------ 130
L L +N L LP G L+ L +SGN L AL P+L +L
Sbjct: 49 LLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSA 108
Query: 131 -----------RHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRL 178
R L V++LS N + +P S+ EL+ ++ L+L NQ+ I +I L
Sbjct: 109 LPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSL 168
Query: 179 KILRLEENCL-----ELSMLPQ---SILSDSQICLLAVEGNLFEIKKLREL 221
+ L L N + EL LP +L D++I ++ L ++ LR L
Sbjct: 169 ECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKI--QSIPPQLSQLHSLRSL 217
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 84.3 bits (207), Expect = 8e-17
Identities = 60/218 (27%), Positives = 112/218 (51%), Gaps = 32/218 (14%)
Query: 10 VETAQKTGVFQLKDRGLTEFP-----------ADLQK-----------LTSNLRTIDLSN 47
+E A +G+ L R L +FP ADL + L + L T++L +
Sbjct: 84 LEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYH 143
Query: 48 NKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQL 107
N I+++P I +L L+++ N L+ LP + +L L+ L ++NN L +P G+L
Sbjct: 144 NCIKTIPEA-IKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKL 201
Query: 108 SALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQ 167
L L +S N++ LP Q+ L L +++ +N + +PD +G+L +++L+ + N++++
Sbjct: 202 KDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTE 261
Query: 168 ISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICL 205
I V L+++ L+ N L+ + +QICL
Sbjct: 262 IPVCYRKLHHLQVIILDNNPLQ--------VPPAQICL 291
Score = 42.7 bits (99), Expect = 3e-04
Identities = 42/139 (30%), Positives = 58/139 (41%), Gaps = 7/139 (5%)
Query: 91 SLNNNH-LRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDS 149
SL H +R L + + LSLSG +L P L DLS+N+ IP
Sbjct: 70 SLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSD 129
Query: 150 VGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLE-----LSMLPQSILSDSQI 203
V +E LNL N I I I L L + N L L LP +L S
Sbjct: 130 VWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNN 189
Query: 204 CLLAVEGNLFEIKKLRELE 222
L+++ + ++K L EL+
Sbjct: 190 KLVSIPEEIGKLKDLMELD 208
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 84.0 bits (206), Expect = 1e-16
Identities = 67/205 (32%), Positives = 101/205 (49%), Gaps = 28/205 (13%)
Query: 10 VETAQKTGVFQLKDRGLTEFP--ADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSL 67
+E A TGV L R L EFP A LT R DLS N++ +P + F L++L
Sbjct: 53 LEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRA-DLSRNRLSEIP-IEACHFVSLENL 110
Query: 68 SLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQL 127
+L N + +P+ I NL+ L L+++ N L LP L LK L S N+L +LP ++
Sbjct: 111 NLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVLIASNNKLVSLPEEI 169
Query: 128 CSLRHLDVMDLSKNQIRSIPDSVG-----------------------ELQVIELNLNQNQ 164
LRHL +D+S N+I++IP +G EL +I L+ + N+
Sbjct: 170 GHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNK 229
Query: 165 ISQISVKISCCPRLKILRLEENCLE 189
I+ I V L+ + L+ N L+
Sbjct: 230 ITTIPVCYRNLRHLQTITLDNNPLQ 254
Score = 38.1 bits (87), Expect = 0.007
Identities = 30/115 (26%), Positives = 55/115 (47%), Gaps = 27/115 (23%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEIC--- 82
L P ++ L +L +D+S N+I+++P IG L+ L++ N L LP+E+
Sbjct: 162 LVSLPEEIGHLR-HLMELDVSCNEIQTIPSQ-IGNLEALRDLNVRRNHLVHLPEELAELP 219
Query: 83 -------------------NLKKLETLSLNNNHLRELPSTF---GQLSALKTLSL 115
NL+ L+T++L+NN L+ P+ G++ K L++
Sbjct: 220 LIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNI 274
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 83.2 bits (204), Expect = 2e-16
Identities = 62/178 (34%), Positives = 96/178 (53%), Gaps = 8/178 (4%)
Query: 39 NLRTIDLSNNKIESLPPLLIGKFTL--LKSLSLNNNKLTVLPDEICNLKKLETLSLNNNH 96
N +D+S+ I ++ + G FTL + L L++NKLT++P I LK LE L+ NN
Sbjct: 16 NQPEVDMSDRGISNMLDVN-GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQ 74
Query: 97 LRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQI--RSIPDSVGELQ 154
+ ELP+ L LK L+L N+L LP SL L+V+DL+ N + S+P + L
Sbjct: 75 IEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT 134
Query: 155 VIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGN 211
+ L L+ N + I +L+IL L +N +L LP+ I +Q+ L ++GN
Sbjct: 135 TLRALYLSDNDFEILPPDIGKLTKLQILSLRDN--DLISLPKEIGELTQLKELHIQGN 190
Score = 66.2 bits (160), Expect = 2e-11
Identities = 45/126 (35%), Positives = 65/126 (51%), Gaps = 2/126 (1%)
Query: 6 LRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLS-NNKIESLPPLLIGKFTLL 64
L + + QK L L P L + L +DL+ NN E+ P T L
Sbjct: 78 LPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA-LEVLDLTYNNLSENSLPGNFFYLTTL 136
Query: 65 KSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALP 124
++L L++N +LP +I L KL+ LSL +N L LP G+L+ LK L + GN+L LP
Sbjct: 137 RALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
Query: 125 PQLCSL 130
P+L +L
Sbjct: 197 PELGNL 202
Score = 62.0 bits (149), Expect = 4e-10
Identities = 48/160 (30%), Positives = 71/160 (44%), Gaps = 27/160 (16%)
Query: 21 LKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDE 80
L LT P ++ +L NL ++ NN+IE LP I LK L+L N+L LP
Sbjct: 47 LSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQ-ISSLQKLKHLNLGMNRLNTLPRG 104
Query: 81 ICNLKKLETLSLNNNHLRE-------------------------LPSTFGQLSALKTLSL 115
+L LE L L N+L E LP G+L+ L+ LSL
Sbjct: 105 FGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSL 164
Query: 116 SGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQV 155
N L +LP ++ L L + + N++ +P +G L +
Sbjct: 165 RDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 204
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 82.4 bits (202), Expect = 3e-16
Identities = 58/195 (29%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
Query: 21 LKDRGLTEFPADLQKLTS--NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLP 78
L R L FP +L K L + + N + SLP L K L L L++N + V+P
Sbjct: 22 LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVP 81
Query: 79 DEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDL 138
+ I +L KL+ L L++N L + G+L AL+ L L+ NQL LPP++ L+ L +D+
Sbjct: 82 EAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDI 141
Query: 139 SKNQIRSIPDSVGE-LQVIELNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSI 197
S N++ ++P+ + L + L +++N++ + + P L L + N L+ LP +
Sbjct: 142 STNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGN--RLAFLPLDL 199
Query: 198 LSDSQICLLAVEGNL 212
++ + V+ N+
Sbjct: 200 GRSRELQYVYVDNNI 214
>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
Length = 261
Score = 81.6 bits (200), Expect = 5e-16
Identities = 46/149 (30%), Positives = 89/149 (59%), Gaps = 4/149 (2%)
Query: 41 RTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLREL 100
+ +DLS I + P ++ + + + L L+ N + +PD I + L L L++N++ +L
Sbjct: 30 KRLDLSKMGITTFPKCIL-RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKL 88
Query: 101 PSTFGQLSALKTLSLSGNQL--GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-E 157
P + GQ+++L L++S N+L LP +L L+++ ++L N + S+P ++G L+ + E
Sbjct: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
Query: 158 LNLNQNQISQISVKISCCPRLKILRLEEN 186
+ L+ N ++ I V IS P+LK L ++ N
Sbjct: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
Score = 66.2 bits (160), Expect = 2e-11
Identities = 41/118 (34%), Positives = 65/118 (55%), Gaps = 4/118 (3%)
Query: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTV--LPDEICN 83
+ + P + K NLR +DL +N I+ LP IG+ T L L+++NN+LT LP E+
Sbjct: 62 IRKIPDSISKF-QNLRWLDLHSNYIDKLPE-SIGQMTSLLYLNVSNNRLTSNGLPVELKQ 119
Query: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKN 141
LK + ++L NHL +P+T G L L + L N L +P + L L +++ +N
Sbjct: 120 LKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 81.6 bits (200), Expect = 5e-16
Identities = 61/203 (30%), Positives = 102/203 (50%), Gaps = 28/203 (13%)
Query: 19 FQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFT---------------- 62
F L RG+T+ P L L S ++ ++LS+N++ LPP +GK T
Sbjct: 53 FSLVTRGMTDIPDFLWGL-SEVQKLNLSHNQLRVLPPE-VGKLTRIVVLNLCGNRLKSLP 110
Query: 63 -------LLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSL 115
LK L +N N LT +P E+ +KLE LSL++N L +LP+ F LS L+ L+L
Sbjct: 111 REVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNL 170
Query: 116 SGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQ-NQISQISVKISC 174
S N +P + SL+ L + + N++ +I +S+ L +++ + + N I +
Sbjct: 171 SNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCL 230
Query: 175 CPRLKILRLEENCLELSMLPQSI 197
L++L L N ++ LP +
Sbjct: 231 VTSLELLNLNNN--DIQTLPSEL 251
Score = 69.7 bits (169), Expect = 2e-12
Identities = 45/150 (30%), Positives = 82/150 (54%), Gaps = 3/150 (2%)
Query: 66 SLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPP 125
S SL +T +PD + L +++ L+L++N LR LP G+L+ + L+L GN+L +LP
Sbjct: 52 SFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPR 111
Query: 126 QLCSLRHLDVMDLSKNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLE 184
++ L+ L V+ ++ N + +P + + +E L+L+ N +SQ+ + RL+ L L
Sbjct: 112 EVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLS 171
Query: 185 ENCLELSMLPQSILSDSQICLLAVEGNLFE 214
N + +P + S ++ L V N E
Sbjct: 172 NNF--FAHIPMCVFSLKELIFLHVGSNRLE 199
Score = 41.2 bits (95), Expect = 8e-04
Identities = 44/151 (29%), Positives = 61/151 (40%), Gaps = 32/151 (21%)
Query: 8 AHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPP----------LL 57
A + +K V L L++ PA L S LR ++LSNN +P L
Sbjct: 134 AELSLCRKLEVLSLSHNCLSQLPACFADL-SRLRKLNLSNNFFAHIPMCVFSLKELIFLH 192
Query: 58 IGKFTL---------LKSLSL---NNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFG 105
+G L L SL + N + P +C + LE L+LNNN ++ LPS
Sbjct: 193 VGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLPSELH 252
Query: 106 QLSAL---------KTLSLSGNQLGALPPQL 127
L L K L +S N L P+L
Sbjct: 253 LLCRLVRIAWNPMDKGLHISHNPLSKPLPEL 283
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 81.3 bits (199), Expect = 7e-16
Identities = 42/113 (37%), Positives = 74/113 (65%), Gaps = 1/113 (0%)
Query: 38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHL 97
+ ++ +DL +N++ +LP L G+ T L+ L++ N+L LP I NL +L+TL++ +N L
Sbjct: 81 ATIKVLDLHDNQLTALPDDL-GQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKL 139
Query: 98 RELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSV 150
+ELP T G+L +L+TL++SGN++ LP L +R L+++ L + + P V
Sbjct: 140 KELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREV 192
Score = 73.2 bits (178), Expect = 2e-13
Identities = 38/120 (31%), Positives = 71/120 (59%), Gaps = 2/120 (1%)
Query: 41 RTIDLSNNKIESLPPLLIGKFTL--LKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLR 98
+ + + N + SL P +L +K L L++N+LT LPD++ L L+ L++ N L
Sbjct: 58 KVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLM 117
Query: 99 ELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIEL 158
+LP + G L+ L+TL++ N+L LP + LR L +++S N+I+ +P + ++ +E+
Sbjct: 118 QLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEM 177
Score = 68.2 bits (165), Expect = 6e-12
Identities = 38/111 (34%), Positives = 64/111 (57%), Gaps = 2/111 (1%)
Query: 18 VFQLKDRGLTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL 77
V L D LT P DL +LT+ L+ +++ N++ LP IG T L++L++ +NKL L
Sbjct: 85 VLDLHDNQLTALPDDLGQLTA-LQVLNVERNQLMQLPRS-IGNLTQLQTLNVKDNKLKEL 142
Query: 78 PDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLC 128
PD + L+ L TL+++ N ++ LP + L+ LSL + + P ++C
Sbjct: 143 PDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVC 193
Score = 58.5 bits (140), Expect = 5e-09
Identities = 44/151 (29%), Positives = 81/151 (53%), Gaps = 15/151 (9%)
Query: 88 ETLSLNNNHLRELPSTFGQLSALKTLS-----LSGNQLGALPPQLCSLRHL---DVMDLS 139
+ L ++ L E+P FG + K L + N L +L P+ CSL L V+DL
Sbjct: 32 DILDISKCELSEIP--FGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLH 89
Query: 140 KNQIRSIPDSVGELQVIE-LNLNQNQISQISVKISCCPRLKILRLEENCLELSMLPQSIL 198
NQ+ ++PD +G+L ++ LN+ +NQ+ Q+ I +L+ L +++N +L LP ++
Sbjct: 90 DNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDN--KLKELPDTVG 147
Query: 199 SDSQICLLAVEGNLFEIKKLRELEGYDKYME 229
+ L + GN EI++L ++ + + +E
Sbjct: 148 ELRSLRTLNISGN--EIQRLPQMLAHVRTLE 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,029,211
Number of Sequences: 37866
Number of extensions: 317142
Number of successful extensions: 2950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 946
Number of HSP's gapped (non-prelim): 992
length of query: 239
length of database: 18,247,518
effective HSP length: 99
effective length of query: 140
effective length of database: 14,498,784
effective search space: 2029829760
effective search space used: 2029829760
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.