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Search of human proteins with 194328725
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194328725 Src-like-adaptor isoform b [Homo sapiens]
(293 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194328725 Src-like-adaptor isoform b [Homo sapiens] 602 e-172
gi|194328732 Src-like-adaptor isoform c [Homo sapiens] 598 e-171
gi|113930754 Src-like-adaptor isoform a [Homo sapiens] 566 e-161
gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] 190 1e-48
gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens] 146 2e-35
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 142 3e-34
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 139 2e-33
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 136 3e-32
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 132 3e-31
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 132 3e-31
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 132 3e-31
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 126 3e-29
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 124 1e-28
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 122 5e-28
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 122 5e-28
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 122 5e-28
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 119 3e-27
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 114 8e-26
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 114 8e-26
gi|4503787 fyn-related kinase [Homo sapiens] 109 3e-24
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 105 4e-23
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 75 7e-14
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 75 7e-14
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 74 2e-13
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 74 2e-13
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 74 2e-13
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 74 2e-13
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 74 2e-13
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 71 1e-12
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 68 8e-12
>gi|194328725 Src-like-adaptor isoform b [Homo sapiens]
Length = 293
Score = 602 bits (1551), Expect = e-172
Identities = 293/293 (100%), Positives = 293/293 (100%)
Query: 1 MLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF 60
MLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF
Sbjct: 1 MLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF 60
Query: 61 RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT 120
RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT
Sbjct: 61 RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT 120
Query: 121 KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV 180
KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV
Sbjct: 121 KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV 180
Query: 181 ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES 240
ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES
Sbjct: 181 ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES 240
Query: 241 LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 293
LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED
Sbjct: 241 LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 293
>gi|194328732 Src-like-adaptor isoform c [Homo sapiens]
Length = 316
Score = 598 bits (1543), Expect = e-171
Identities = 291/293 (99%), Positives = 292/293 (99%)
Query: 1 MLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF 60
+ HRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF
Sbjct: 24 LYHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIF 83
Query: 61 RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT 120
RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT
Sbjct: 84 RRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDT 143
Query: 121 KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV 180
KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV
Sbjct: 144 KVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEV 203
Query: 181 ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES 240
ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES
Sbjct: 204 ADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDES 263
Query: 241 LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 293
LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED
Sbjct: 264 LFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 316
>gi|113930754 Src-like-adaptor isoform a [Homo sapiens]
Length = 276
Score = 566 bits (1458), Expect = e-161
Identities = 276/276 (100%), Positives = 276/276 (100%)
Query: 18 MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWK 77
MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWK
Sbjct: 1 MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWK 60
Query: 78 AISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY 137
AISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY
Sbjct: 61 AISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY 120
Query: 138 SLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST 197
SLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST
Sbjct: 121 SLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST 180
Query: 198 AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT 257
AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT
Sbjct: 181 AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT 240
Query: 258 SEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 293
SEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED
Sbjct: 241 SEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED 276
>gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens]
Length = 261
Score = 190 bits (483), Expect = 1e-48
Identities = 101/254 (39%), Positives = 147/254 (57%), Gaps = 10/254 (3%)
Query: 12 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 71
P ++K + + S+ + P+ L +P+ + R GE L ++S+
Sbjct: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64
Query: 72 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 131
+G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+
Sbjct: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124
Query: 132 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLC 185
T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE+AD +C
Sbjct: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDIC 184
Query: 186 CVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYG 245
C+L PC+ Q + PVT+++ ++W+ + E +ESL S G
Sbjct: 185 CLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATG----EESLLSEG 240
Query: 246 LRESIASYLSLTSE 259
LRES++ Y+SL E
Sbjct: 241 LRESLSFYISLNDE 254
>gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens]
Length = 210
Score = 146 bits (369), Expect = 2e-35
Identities = 75/174 (43%), Positives = 105/174 (60%), Gaps = 6/174 (3%)
Query: 12 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 71
P ++K + + S+ + P+ L +P+ + R GE L ++S+
Sbjct: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64
Query: 72 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 131
+G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+
Sbjct: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124
Query: 132 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSE 179
T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE
Sbjct: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE 178
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 142 bits (358), Expect = 3e-34
Identities = 83/180 (46%), Positives = 101/180 (56%), Gaps = 11/180 (6%)
Query: 32 PLPNPEGLDSD--FLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYI 89
P P E LD D F+ L DY + + +GEKL+V+ G WW A SL TGRE Y+
Sbjct: 49 PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYV 108
Query: 90 PGICVARV----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH-- 143
P VARV W F GR +AE L P K GSF+IRESET KG +SLSV+
Sbjct: 109 PSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT 168
Query: 144 ---RQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAP 200
+KHY+I L YYISPR+TF L+ LV HYS+ DGLC LT PC+ + P
Sbjct: 169 TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNP 228
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 139 bits (351), Expect = 2e-33
Identities = 84/206 (40%), Positives = 113/206 (54%), Gaps = 12/206 (5%)
Query: 7 ASPAAPGKKKEMGNSMKSTPAPAERPLPN--PEGLDSDFLAVLSDYPSPDISPPIFRRGE 64
ASP P + +++K P P G + + L DY + F++G+
Sbjct: 44 ASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGD 103
Query: 65 KLRVISDEGGWWKAISLSTGRESYIPGICVARV----YHGWLFEGLGRDKAEELLQLPDT 120
++ V+ + G WWKA SL+T +E YIP VARV W F+G+ R AE L P
Sbjct: 104 QMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGN 163
Query: 121 KVGSFMIRESETKKGFYSLSVRH---RQ---VKHYRIFRLPNNWYYISPRLTFQCLEDLV 174
+GSFMIR+SET KG YSLSVR RQ VKHY+I L N +YISPR TF L++LV
Sbjct: 164 MLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELV 223
Query: 175 NHYSEVADGLCCVLTTPCLTQSTAAP 200
+HY + DGLC L+ PC++ P
Sbjct: 224 DHYKKGNDGLCQKLSVPCMSSKPQKP 249
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 136 bits (342), Expect = 3e-32
Identities = 80/201 (39%), Positives = 109/201 (54%), Gaps = 22/201 (10%)
Query: 19 GNSMKSTPAPAERPLP-------NPEGLDSDFLAVLSDYPSPDISPP--IFRRGEKLRVI 69
G +K+ P P + LP +PE D + L YP I P F++GEK++V+
Sbjct: 16 GVDLKTQPVPESQLLPGQRFQTKDPEE-QGDIVVAL--YPYDGIHPDDLSFKKGEKMKVL 72
Query: 70 SDEGGWWKAISLSTGRESYIPGICVARVY----HGWLFEGLGRDKAEELLQLPDTKVGSF 125
+ G WWKA SL T +E +IP VA++ W F+ + R AE L P G+F
Sbjct: 73 EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAF 132
Query: 126 MIRESETKKGFYSLSVRHRQ------VKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSE 179
+IRESET KG +SLSVR +KHY+I L N YYISPR+TF C+ D++ HY +
Sbjct: 133 LIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQK 192
Query: 180 VADGLCCVLTTPCLTQSTAAP 200
ADGLC L C++ P
Sbjct: 193 QADGLCRRLEKACISPKPQKP 213
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 132 bits (333), Expect = 3e-31
Identities = 76/192 (39%), Positives = 100/192 (52%), Gaps = 10/192 (5%)
Query: 19 GNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKA 78
G+ ++ E P L + + L Y F +GE+LR++ G WWKA
Sbjct: 41 GSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
Query: 79 ISLSTGRESYIPGICVARVY----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKK 134
SL+TG+E +IP VA+ W F+ L R AE L P GSF+IRESE+
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
Query: 135 GFYSLSVRH------RQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVL 188
G +SLSVR VKHY+I L N +YISPR+TF L +LV HY+ +DGLC L
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
Query: 189 TTPCLTQSTAAP 200
+ PC TQ P
Sbjct: 221 SRPCQTQKPQKP 232
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 132 bits (333), Expect = 3e-31
Identities = 76/192 (39%), Positives = 100/192 (52%), Gaps = 10/192 (5%)
Query: 19 GNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKA 78
G+ ++ E P L + + L Y F +GE+LR++ G WWKA
Sbjct: 41 GSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
Query: 79 ISLSTGRESYIPGICVARVY----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKK 134
SL+TG+E +IP VA+ W F+ L R AE L P GSF+IRESE+
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
Query: 135 GFYSLSVRH------RQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVL 188
G +SLSVR VKHY+I L N +YISPR+TF L +LV HY+ +DGLC L
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
Query: 189 TTPCLTQSTAAP 200
+ PC TQ P
Sbjct: 221 SRPCQTQKPQKP 232
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 132 bits (333), Expect = 3e-31
Identities = 71/167 (42%), Positives = 97/167 (58%), Gaps = 12/167 (7%)
Query: 46 VLSDYPSPDISPP--IFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVY----H 99
V++ YP I P F++GEK++V+ + G WWKA SL T +E +IP VA++
Sbjct: 68 VVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 127
Query: 100 GWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHRQ------VKHYRIFR 153
W F+ + R AE L P G+F+IRESET KG +SLSVR +KHY+I
Sbjct: 128 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 187
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAP 200
L N YYISPR+TF C+ D++ HY + ADGLC L C++ P
Sbjct: 188 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKP 234
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 126 bits (316), Expect = 3e-29
Identities = 75/176 (42%), Positives = 97/176 (55%), Gaps = 13/176 (7%)
Query: 32 PLPNPEGLDSD--FLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTGRESY 88
P P GL L DY + F++GE+ ++I++ EG WW+A S++TG+ Y
Sbjct: 82 PSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGY 141
Query: 89 IPGICVARV----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH- 143
IP VA W F +GR AE LL P + G F++RESET KG YSLS+R
Sbjct: 142 IPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDW 201
Query: 144 -----RQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLT 194
VKHY+I +L N YYI+ R F L+ LV HY+E ADGLC LTT C T
Sbjct: 202 DEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPT 257
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 124 bits (310), Expect = 1e-28
Identities = 74/166 (44%), Positives = 89/166 (53%), Gaps = 11/166 (6%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVI-SDEGGWWKAISLSTGRESYIPGICVAR 96
G L DY + F +GEK +++ S EG WW+A SL+TG YIP VA
Sbjct: 81 GTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP 140
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F LGR AE L G+F+IRESET KG YSLS+R V
Sbjct: 141 VDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPC 192
KHY+I +L N YYI+ R F+ L+ LV HYSE A GLCC L PC
Sbjct: 201 KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPC 246
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 122 bits (305), Expect = 5e-28
Identities = 76/193 (39%), Positives = 101/193 (52%), Gaps = 16/193 (8%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTGRESYIPGICVAR 96
G+ L DY + F +GEK ++++ EG WW+A SLS+G+ IP VA
Sbjct: 76 GIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP 135
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F +GR AE L P G+F+IRESET KG YSLS+R V
Sbjct: 136 VDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCL-----TQSTAAPA 201
KHY+I +L YYI+ R+ F +++LV HY EV DGLC +L PC T A A
Sbjct: 196 KHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDA 255
Query: 202 VRASSSPVTLRQK 214
S S +TL ++
Sbjct: 256 WEISRSSITLERR 268
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 122 bits (305), Expect = 5e-28
Identities = 76/193 (39%), Positives = 101/193 (52%), Gaps = 16/193 (8%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTGRESYIPGICVAR 96
G+ L DY + F +GEK ++++ EG WW+A SLS+G+ IP VA
Sbjct: 76 GIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP 135
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F +GR AE L P G+F+IRESET KG YSLS+R V
Sbjct: 136 VDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCL-----TQSTAAPA 201
KHY+I +L YYI+ R+ F +++LV HY EV DGLC +L PC T A A
Sbjct: 196 KHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDA 255
Query: 202 VRASSSPVTLRQK 214
S S +TL ++
Sbjct: 256 WEISRSSITLERR 268
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 122 bits (305), Expect = 5e-28
Identities = 76/193 (39%), Positives = 101/193 (52%), Gaps = 16/193 (8%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTGRESYIPGICVAR 96
G+ L DY + F +GEK ++++ EG WW+A SLS+G+ IP VA
Sbjct: 76 GIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP 135
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F +GR AE L P G+F+IRESET KG YSLS+R V
Sbjct: 136 VDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCL-----TQSTAAPA 201
KHY+I +L YYI+ R+ F +++LV HY EV DGLC +L PC T A A
Sbjct: 196 KHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDA 255
Query: 202 VRASSSPVTLRQK 214
S S +TL ++
Sbjct: 256 WEISRSSITLERR 268
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 119 bits (298), Expect = 3e-27
Identities = 74/174 (42%), Positives = 93/174 (53%), Gaps = 14/174 (8%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVI-SDEGGWWKAISLSTGRESYIPGICVAR 96
G L DY + F +GEK +++ S EG WW+A SL+TG YIP VA
Sbjct: 81 GTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP 140
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F LGR AE L G+F+IRESET KG YSLS+R V
Sbjct: 141 VDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLC---CVLTTPCLTQST 197
KHY+I +L N YYI+ R F+ L+ LV HYSE ADGLC V+ + C Q++
Sbjct: 201 KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTS 254
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 114 bits (286), Expect = 8e-26
Identities = 76/198 (38%), Positives = 107/198 (54%), Gaps = 13/198 (6%)
Query: 8 SPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLR 67
+PAA K G + T +R P G+ + L DY S + F++GE+L+
Sbjct: 55 APAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT--FVALYDYESRTETDLSFKKGERLQ 112
Query: 68 VISD-EGGWWKAISLSTGRESYIPGICVARV----YHGWLFEGLGRDKAEELLQLPDTKV 122
++++ EG WW A SLSTG+ YIP VA W F + R ++E LL +
Sbjct: 113 IVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPR 172
Query: 123 GSFMIRESETKKGFYSLSV------RHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNH 176
G+F++RESET KG Y LSV + VKHY+I +L + +YI+ R F L+ LV +
Sbjct: 173 GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAY 232
Query: 177 YSEVADGLCCVLTTPCLT 194
YS+ ADGLC LTT C T
Sbjct: 233 YSKHADGLCHRLTTVCPT 250
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 114 bits (286), Expect = 8e-26
Identities = 76/198 (38%), Positives = 107/198 (54%), Gaps = 13/198 (6%)
Query: 8 SPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLR 67
+PAA K G + T +R P G+ + L DY S + F++GE+L+
Sbjct: 55 APAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT--FVALYDYESRTETDLSFKKGERLQ 112
Query: 68 VISD-EGGWWKAISLSTGRESYIPGICVARV----YHGWLFEGLGRDKAEELLQLPDTKV 122
++++ EG WW A SLSTG+ YIP VA W F + R ++E LL +
Sbjct: 113 IVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPR 172
Query: 123 GSFMIRESETKKGFYSLSV------RHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNH 176
G+F++RESET KG Y LSV + VKHY+I +L + +YI+ R F L+ LV +
Sbjct: 173 GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAY 232
Query: 177 YSEVADGLCCVLTTPCLT 194
YS+ ADGLC LTT C T
Sbjct: 233 YSKHADGLCHRLTTVCPT 250
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 109 bits (273), Expect = 3e-24
Identities = 79/220 (35%), Positives = 103/220 (46%), Gaps = 28/220 (12%)
Query: 24 STPAPAERPLPNPEGLDSD-------FLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGW 75
ST A + NP L S + L DY + FR G+KL+V+ GW
Sbjct: 20 STEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGW 79
Query: 76 WKAISLSTGRES-------YIPGICVAR----VYHGWLFEGLGRDKAEELLQLPDTKVGS 124
W A L R+ YIP VA W F +GR AE+ L + K GS
Sbjct: 80 WFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGS 139
Query: 125 FMIRESETKKGFYSLSVRHRQV-KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADG 183
F+IRESE++KG +SLSV V KHYRI RL ++++ R F L + V+HY++ +DG
Sbjct: 140 FLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDG 199
Query: 184 LCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSR 223
LC L PCL A P L KTVD + R
Sbjct: 200 LCVKLGKPCLKIQVPA--------PFDLSYKTVDQWEIDR 231
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 105 bits (263), Expect = 4e-23
Identities = 66/157 (42%), Positives = 82/157 (52%), Gaps = 11/157 (7%)
Query: 38 GLDSDFLAVLSDYPSPDISPPIFRRGEKLRVI-SDEGGWWKAISLSTGRESYIPGICVAR 96
G L DY + F +GEK +++ S EG WW+A SL+TG YIP VA
Sbjct: 81 GTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP 140
Query: 97 V----YHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRH------RQV 146
V W F LGR AE L G+F+IRESET KG YSLS+R V
Sbjct: 141 VDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
Query: 147 KHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADG 183
KHY+I +L N YYI+ R F+ L+ LV HYS +G
Sbjct: 201 KHYKIRKLDNGGYYITTRAQFETLQQLVQHYSGTWNG 237
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 75.1 bits (183), Expect = 7e-14
Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 9/168 (5%)
Query: 30 ERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESY 88
E L P D + L D+ + + +GEKLRV+ + G W G + +
Sbjct: 52 ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGW 110
Query: 89 IPGICVARVY----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR 144
+P + V H W + R+ AE LL GSF++RESE+ G S+S+R+
Sbjct: 111 VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE 168
Query: 145 -QVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+V HYRI + Y+S F L +LV+H+S VADGL L P
Sbjct: 169 GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 216
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 75.1 bits (183), Expect = 7e-14
Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 9/168 (5%)
Query: 30 ERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESY 88
E L P D + L D+ + + +GEKLRV+ + G W G + +
Sbjct: 71 ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGW 129
Query: 89 IPGICVARVY----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR 144
+P + V H W + R+ AE LL GSF++RESE+ G S+S+R+
Sbjct: 130 VPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYE 187
Query: 145 -QVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+V HYRI + Y+S F L +LV+H+S VADGL L P
Sbjct: 188 GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 235
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 9/158 (5%)
Query: 40 DSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESYIPGICVARVY 98
D + L D+ + + +GEKLRV+ ++ G W + G + ++P + V
Sbjct: 93 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVN 151
Query: 99 ----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFR 153
H W + R AE LL GSF++RESE+ G S+S+R+ +V HYRI
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLS--SLINGSFLVRESESSPGQLSISLRYEGRVYHYRINT 209
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+ Y++ F L +LV+H+S VADGL L P
Sbjct: 210 TADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 247
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 9/158 (5%)
Query: 40 DSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESYIPGICVARVY 98
D + L D+ + + +GEKLRV+ ++ G W + G + ++P + V
Sbjct: 108 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVN 166
Query: 99 ----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFR 153
H W + R AE LL GSF++RESE+ G S+S+R+ +V HYRI
Sbjct: 167 SLEKHSWYHGPVSRSAAEYLLS--SLINGSFLVRESESSPGQLSISLRYEGRVYHYRINT 224
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+ Y++ F L +LV+H+S VADGL L P
Sbjct: 225 TADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 262
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 9/158 (5%)
Query: 40 DSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESYIPGICVARVY 98
D + L D+ + + +GEKLRV+ ++ G W + G + ++P + V
Sbjct: 87 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVN 145
Query: 99 ----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFR 153
H W + R AE LL GSF++RESE+ G S+S+R+ +V HYRI
Sbjct: 146 SLEKHSWYHGPVSRSAAEYLLS--SLINGSFLVRESESSPGQLSISLRYEGRVYHYRINT 203
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+ Y++ F L +LV+H+S VADGL L P
Sbjct: 204 TADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 241
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 9/158 (5%)
Query: 40 DSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESYIPGICVARVY 98
D + L D+ + + +GEKLRV+ ++ G W + G + ++P + V
Sbjct: 93 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVN 151
Query: 99 ----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFR 153
H W + R AE LL GSF++RESE+ G S+S+R+ +V HYRI
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLS--SLINGSFLVRESESSPGQLSISLRYEGRVYHYRINT 209
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+ Y++ F L +LV+H+S VADGL L P
Sbjct: 210 TADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 247
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/158 (32%), Positives = 78/158 (49%), Gaps = 9/158 (5%)
Query: 40 DSDFLAVLSDYPSPDISPPIFRRGEKLRVIS-DEGGWWKAISLSTGRESYIPGICVARVY 98
D + L D+ + + +GEKLRV+ ++ G W + G + ++P + V
Sbjct: 72 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVN 130
Query: 99 ----HGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHR-QVKHYRIFR 153
H W + R AE LL GSF++RESE+ G S+S+R+ +V HYRI
Sbjct: 131 SLEKHSWYHGPVSRSAAEYLLS--SLINGSFLVRESESSPGQLSISLRYEGRVYHYRINT 188
Query: 154 LPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTP 191
+ Y++ F L +LV+H+S VADGL L P
Sbjct: 189 TADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 226
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 71.2 bits (173), Expect = 1e-12
Identities = 54/212 (25%), Positives = 98/212 (46%), Gaps = 19/212 (8%)
Query: 3 HRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRR 62
HR P P +++ P PA P+ E + L DY + + R+
Sbjct: 181 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSE---LKKVVALYDYMPMNANDLQLRK 237
Query: 63 GEKLRVISDEG-GWWKAISLSTGRESYIPGICVARV-----YHGWLFEGLGRDKAEELLQ 116
G++ ++ + WW+A G+E YIP V + W + + R +AE+LL+
Sbjct: 238 GDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLK 296
Query: 117 LPDTKVGSFMIRESETKKGFYSLSVRHRQ-------VKHYRIFRLPNNWYYISPRLTFQC 169
+ K G F++R+S +K G Y++SV + ++HY + P + YY++ + F
Sbjct: 297 -QEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFST 354
Query: 170 LEDLVNHYSEVADGLCCVLTTPCLTQSTAAPA 201
+ +L+N++ + GL L P Q+ AP+
Sbjct: 355 IPELINYHQHNSAGLISRLKYPVSQQNKNAPS 386
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 68.2 bits (165), Expect = 8e-12
Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 23/193 (11%)
Query: 25 TPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVI-SDEGGWWKAISLST 83
TP RPL PE + L DY + D RR E+ ++ S E WW+ +
Sbjct: 160 TPEDNRRPLWEPE---ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWR-VQDRN 215
Query: 84 GRESYIPGICVAR------VYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY 137
G E Y+P + + W + + RDKAE+LL L K G+FM+R+S T G Y
Sbjct: 216 GHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLL-LDTGKEGAFMVRDSRT-AGTY 273
Query: 138 SLSVRHRQV--------KHYRIFRLPNN--WYYISPRLTFQCLEDLVNHYSEVADGLCCV 187
++SV + V KHY I +N YY++ + F + L+N++ GL
Sbjct: 274 TVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTR 333
Query: 188 LTTPCLTQSTAAP 200
L P AP
Sbjct: 334 LRYPVCFGRQKAP 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,669,659
Number of Sequences: 37866
Number of extensions: 616460
Number of successful extensions: 2467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 2291
Number of HSP's gapped (non-prelim): 190
length of query: 293
length of database: 18,247,518
effective HSP length: 101
effective length of query: 192
effective length of database: 14,423,052
effective search space: 2769225984
effective search space used: 2769225984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.