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Search of human proteins with 194306653
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
sapiens]
(504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo sap... 1025 0.0
gi|5174751 Yes-associated protein 1, 65kDa isoform 2 [Homo sapiens] 881 0.0
gi|13346498 WW domain containing transcription regulator 1 [Homo... 333 3e-91
gi|222352183 neural precursor cell expressed, developmentally do... 85 1e-16
gi|21361472 neural precursor cell expressed, developmentally dow... 85 1e-16
gi|222352094 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352092 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352090 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352088 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352086 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352084 neural precursor cell expressed, developmentally do... 85 1e-16
gi|222352082 neural precursor cell expressed, developmentally do... 85 1e-16
gi|114520609 neural precursor cell expressed, developmentally do... 82 1e-15
gi|114520607 neural precursor cell expressed, developmentally do... 82 1e-15
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 81 2e-15
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 76 8e-14
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 75 1e-13
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 75 1e-13
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 74 2e-13
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 71 3e-12
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 71 3e-12
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 71 3e-12
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 71 3e-12
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 70 4e-12
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 70 4e-12
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 70 4e-12
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 68 2e-11
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 68 2e-11
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 65 1e-10
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 62 1e-09
>gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
sapiens]
Length = 504
Score = 1025 bits (2651), Expect = 0.0
Identities = 504/504 (100%), Positives = 504/504 (100%)
Query: 1 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD 60
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD
Sbjct: 1 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD 60
Query: 61 SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP 120
SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP
Sbjct: 61 SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP 120
Query: 121 QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA 180
QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
Sbjct: 121 QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA 180
Query: 181 KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM 240
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM
Sbjct: 181 KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM 240
Query: 241 TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS 300
TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS
Sbjct: 241 TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS 300
Query: 301 NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG 360
NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG
Sbjct: 301 NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG 360
Query: 361 TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV 420
TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV
Sbjct: 361 TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV 420
Query: 421 DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS 480
DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS
Sbjct: 421 DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS 480
Query: 481 DILNDMESVLAATKLDKESFLTWL 504
DILNDMESVLAATKLDKESFLTWL
Sbjct: 481 DILNDMESVLAATKLDKESFLTWL 504
>gi|5174751 Yes-associated protein 1, 65kDa isoform 2 [Homo sapiens]
Length = 454
Score = 881 bits (2277), Expect = 0.0
Identities = 451/504 (89%), Positives = 452/504 (89%), Gaps = 50/504 (9%)
Query: 1 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD 60
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD
Sbjct: 1 MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGD 60
Query: 61 SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP 120
SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP
Sbjct: 61 SETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTP 120
Query: 121 QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA 180
QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
Sbjct: 121 QHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA 180
Query: 181 KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAM 240
KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS
Sbjct: 181 KTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS----------- 229
Query: 241 TQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS 300
AMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS
Sbjct: 230 ---------------------------AMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNS 262
Query: 301 NQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGG 360
NQQQQMRLQQLQMEKERLRLKQQELLRQ + QELALRSQLPTLEQDGG
Sbjct: 263 NQQQQMRLQQLQMEKERLRLKQQELLRQV------------RPQELALRSQLPTLEQDGG 310
Query: 361 TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV 420
TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV
Sbjct: 311 TQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSV 370
Query: 421 DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS 480
DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS
Sbjct: 371 DEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSS 430
Query: 481 DILNDMESVLAATKLDKESFLTWL 504
DILNDMESVLAATKLDKESFLTWL
Sbjct: 431 DILNDMESVLAATKLDKESFLTWL 454
>gi|13346498 WW domain containing transcription regulator 1 [Homo
sapiens]
Length = 400
Score = 333 bits (853), Expect = 3e-91
Identities = 213/481 (44%), Positives = 286/481 (59%), Gaps = 105/481 (21%)
Query: 43 AAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPK 102
A P PP G Q++HV D +TDLEALFN+VMNPK ++ R + LP+SFFK P+
Sbjct: 6 APPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSS------WRKKILPESFFKEPDSG 59
Query: 103 SHSRQASTDA-----GTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTA 157
SHSRQ+STD+ G A QHVR+HSSPASLQLG TG +G A +P
Sbjct: 60 SHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLG---------TG--AGAAGSPAQ 108
Query: 158 QH--LRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAM---LSQMNV 212
QH LRQ S+++ D++PLP GWEM T++GQRYFLNHI++ TTWQDPRKAM L+ MN+
Sbjct: 109 QHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNL 168
Query: 213 -TAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
A +S PV Q M A++Q + +NH+++ Q
Sbjct: 169 HPAVSSTPVPQRSM-------------AVSQPNLV--MNHQHQ----------------Q 197
Query: 272 RISQSAPVKQPPPLAPQSPQGGVMGGSNS-----NQQQQMRLQQLQMEKERLRLKQQELL 326
+++ S +Q P Q+P G+M N+ QQQ++RLQ++QME+ER+R++Q+EL+
Sbjct: 198 QMAPSTLSQQNHP--TQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELM 255
Query: 327 RQAMRNINPSTANSPKCQELALRSQLP-TLEQDGGTQNPVSSPGMSQELRTMTTNSSDPF 385
R QE AL QLP E Q V+ P M+ ++R++T NSSDPF
Sbjct: 256 R----------------QEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPF 299
Query: 386 LNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQS--TLPSQQNRFPD 443
LN G YHSR++STDSGL + YSVP TP+DFL++VDEMDTG+ Q+ + QQ RFPD
Sbjct: 300 LNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPD 359
Query: 444 YLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTW 503
+L+ +PGTNVDLGTL E E+L+P + ND+ES L + E FLTW
Sbjct: 360 FLDCLPGTNVDLGTL-------ESEDLIP---------LFNDVESALNKS----EPFLTW 399
Query: 504 L 504
L
Sbjct: 400 L 400
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 348 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 400
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 401 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 452
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 453 TQWEDPRLQNPAITGPAVPYSREFKQ 478
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/316 (25%), Positives = 118/316 (37%), Gaps = 86/316 (27%)
Query: 35 QPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVP----MRLRK 90
+P P+ P+ + V++ GDS AL +P + PQ + RL+
Sbjct: 139 EPEPSEGGDVPEPWETISEEVNIAGDSLG--LALPPPPASPGSRTSPQELSEELSRRLQI 196
Query: 91 LPDSFFKP------PEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTP 144
PDS + EP S R S A + H P S G T+T
Sbjct: 197 TPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE-------QGHLPPPSAPAGRARSSTVT- 248
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-- 202
G TP+ ++ + LP+GWE K + G+ Y++NH ++TTTW P
Sbjct: 249 ----GGEEPTPSVAYVHTTP-------GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 297
Query: 203 ------------------------RKAMLSQMNVT--AP----TSPPVQQNMMNSASGP- 231
R LS VT AP PV++ + ++ S P
Sbjct: 298 QLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 357
Query: 232 --------------------LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
LP GWE + +G ++I+H KTT+W DPRL +F ++
Sbjct: 358 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL--KFPVHM 415
Query: 272 RISQSAPVKQPPPLAP 287
R S PL P
Sbjct: 416 RSKTSLNPNDLGPLPP 431
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 64 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 117
Query: 222 Q 222
Q
Sbjct: 118 Q 118
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 449 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 501
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 502 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 553
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 554 TQWEDPRLQNPAITGPAVPYSREFKQ 579
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 55/168 (32%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------------RKAM 206
LP+GWE K + G+ Y++NH ++TTTW P R
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 426
Query: 207 LSQMNVT--AP----TSPPVQQNMMNSASGP---------------------LPDGWEQA 239
LS VT AP PV++ + ++ S P LP GWE
Sbjct: 427 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 486
Query: 240 MTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAP 287
+ +G ++I+H KTT+W DPRL +F ++ R S PL P
Sbjct: 487 IAPNGRPFFIDHNTKTTTWEDPRL--KFPVHMRSKTSLNPNDLGPLPP 532
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 44.3 bits (103), Expect = 3e-04
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%)
Query: 218 PPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PP +++ G LP GWE+ G YY+NH N+TT+W P
Sbjct: 354 PPPSVAYVHTTPG-LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 185 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 238
Query: 222 Q 222
Q
Sbjct: 239 Q 239
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 328 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 380
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 381 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 432
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 433 TQWEDPRLQNPAITGPAVPYSREFKQ 458
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 55/168 (32%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------------RKAM 206
LP+GWE K + G+ Y++NH ++TTTW P R
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 207 LSQMNVT--AP----TSPPVQQNMMNSASGP---------------------LPDGWEQA 239
LS VT AP PV++ + ++ S P LP GWE
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 240 MTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAP 287
+ +G ++I+H KTT+W DPRL +F ++ R S PL P
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRL--KFPVHMRSKTSLNPNDLGPLPP 411
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 44.3 bits (103), Expect = 3e-04
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%)
Query: 218 PPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PP +++ G LP GWE+ G YY+NH N+TT+W P
Sbjct: 233 PPPSVAYVHTTPG-LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 64 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 117
Query: 222 Q 222
Q
Sbjct: 118 Q 118
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 328 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 380
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 381 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 432
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 433 TQWEDPRLQNPAITGPAVPYSREFKQ 458
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 55/168 (32%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------------RKAM 206
LP+GWE K + G+ Y++NH ++TTTW P R
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 305
Query: 207 LSQMNVT--AP----TSPPVQQNMMNSASGP---------------------LPDGWEQA 239
LS VT AP PV++ + ++ S P LP GWE
Sbjct: 306 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 365
Query: 240 MTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAP 287
+ +G ++I+H KTT+W DPRL +F ++ R S PL P
Sbjct: 366 IAPNGRPFFIDHNTKTTTWEDPRL--KFPVHMRSKTSLNPNDLGPLPP 411
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 44.3 bits (103), Expect = 3e-04
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%)
Query: 218 PPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PP +++ G LP GWE+ G YY+NH N+TT+W P
Sbjct: 233 PPPSVAYVHTTPG-LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 64 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 117
Query: 222 Q 222
Q
Sbjct: 118 Q 118
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 441 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 493
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 494 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 545
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 546 TQWEDPRLQNPAITGPAVPYSREFKQ 571
Score = 65.1 bits (157), Expect = 1e-10
Identities = 48/168 (28%), Positives = 69/168 (41%), Gaps = 55/168 (32%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDP--------------------------RKAM 206
LP+GWE K + G+ Y++NH ++TTTW P R
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRS 418
Query: 207 LSQMNVT--AP----TSPPVQQNMMNSASGP---------------------LPDGWEQA 239
LS VT AP PV++ + ++ S P LP GWE
Sbjct: 419 LSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMR 478
Query: 240 MTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAP 287
+ +G ++I+H KTT+W DPRL +F ++ R S PL P
Sbjct: 479 IAPNGRPFFIDHNTKTTTWEDPRL--KFPVHMRSKTSLNPNDLGPLPP 524
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 44.3 bits (103), Expect = 3e-04
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 1/44 (2%)
Query: 218 PPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PP +++ G LP GWE+ G YY+NH N+TT+W P
Sbjct: 346 PPPSVAYVHTTPG-LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 177 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 230
Query: 222 Q 222
Q
Sbjct: 231 Q 231
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 461 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 513
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 514 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 565
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 566 TQWEDPRLQNPAITGPAVPYSREFKQ 591
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/316 (25%), Positives = 118/316 (37%), Gaps = 86/316 (27%)
Query: 35 QPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVP----MRLRK 90
+P P+ P+ + V++ GDS AL +P + PQ + RL+
Sbjct: 252 EPEPSEGGDVPEPWETISEEVNIAGDSLG--LALPPPPASPGSRTSPQELSEELSRRLQI 309
Query: 91 LPDSFFKP------PEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTP 144
PDS + EP S R S A + H P S G T+T
Sbjct: 310 TPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE-------QGHLPPPSAPAGRARSSTVT- 361
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-- 202
G TP+ ++ + LP+GWE K + G+ Y++NH ++TTTW P
Sbjct: 362 ----GGEEPTPSVAYVHTTP-------GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 410
Query: 203 ------------------------RKAMLSQMNVT--AP----TSPPVQQNMMNSASGP- 231
R LS VT AP PV++ + ++ S P
Sbjct: 411 QLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 470
Query: 232 --------------------LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
LP GWE + +G ++I+H KTT+W DPRL +F ++
Sbjct: 471 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL--KFPVHM 528
Query: 272 RISQSAPVKQPPPLAP 287
R S PL P
Sbjct: 529 RSKTSLNPNDLGPLPP 544
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 177 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 230
Query: 222 Q 222
Q
Sbjct: 231 Q 231
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 469 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 521
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 522 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 573
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 574 TQWEDPRLQNPAITGPAVPYSREFKQ 599
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/316 (25%), Positives = 118/316 (37%), Gaps = 86/316 (27%)
Query: 35 QPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVP----MRLRK 90
+P P+ P+ + V++ GDS AL +P + PQ + RL+
Sbjct: 260 EPEPSEGGDVPEPWETISEEVNIAGDSLG--LALPPPPASPGSRTSPQELSEELSRRLQI 317
Query: 91 LPDSFFKP------PEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTP 144
PDS + EP S R S A + H P S G T+T
Sbjct: 318 TPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE-------QGHLPPPSAPAGRARSSTVT- 369
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-- 202
G TP+ ++ + LP+GWE K + G+ Y++NH ++TTTW P
Sbjct: 370 ----GGEEPTPSVAYVHTTP-------GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 418
Query: 203 ------------------------RKAMLSQMNVT--AP----TSPPVQQNMMNSASGP- 231
R LS VT AP PV++ + ++ S P
Sbjct: 419 QLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 478
Query: 232 --------------------LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
LP GWE + +G ++I+H KTT+W DPRL +F ++
Sbjct: 479 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL--KFPVHM 536
Query: 272 RISQSAPVKQPPPLAP 287
R S PL P
Sbjct: 537 RSKTSLNPNDLGPLPP 552
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 185 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 238
Query: 222 Q 222
Q
Sbjct: 239 Q 239
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 348 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 400
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 401 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 452
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 453 TQWEDPRLQNPAITGPAVPYSREFKQ 478
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/316 (25%), Positives = 118/316 (37%), Gaps = 86/316 (27%)
Query: 35 QPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVP----MRLRK 90
+P P+ P+ + V++ GDS AL +P + PQ + RL+
Sbjct: 139 EPEPSEGGDVPEPWETISEEVNIAGDSLG--LALPPPPASPGSRTSPQELSEELSRRLQI 196
Query: 91 LPDSFFKP------PEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTP 144
PDS + EP S R S A + H P S G T+T
Sbjct: 197 TPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE-------QGHLPPPSAPAGRARSSTVT- 248
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-- 202
G TP+ ++ + LP+GWE K + G+ Y++NH ++TTTW P
Sbjct: 249 ----GGEEPTPSVAYVHTTP-------GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 297
Query: 203 ------------------------RKAMLSQMNVT--AP----TSPPVQQNMMNSASGP- 231
R LS VT AP PV++ + ++ S P
Sbjct: 298 QLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 357
Query: 232 --------------------LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
LP GWE + +G ++I+H KTT+W DPRL +F ++
Sbjct: 358 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL--KFPVHM 415
Query: 272 RISQSAPVKQPPPLAP 287
R S PL P
Sbjct: 416 RSKTSLNPNDLGPLPP 431
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 64 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 117
Query: 222 Q 222
Q
Sbjct: 118 Q 118
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 85.1 bits (209), Expect = 1e-16
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 15/146 (10%)
Query: 136 AVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQ 195
AV P P +P QH SF LP GWEM +G+ +F++H +
Sbjct: 348 AVKDTLSNPQSPQPSPYNSPKPQHKVTQSF-------LPPGWEMRIAPNGRPFFIDHNTK 400
Query: 196 TTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKT 255
TTTW+DPR M +P + GPLP GWE+ + DG +YI+H +K
Sbjct: 401 TTTWEDPRLKFPVHMRSKTSLNP--------NDLGPLPPGWEERIHLDGRTFYIDHNSKI 452
Query: 256 TSWLDPRLDPRFAMNQRISQSAPVKQ 281
T W DPRL + S KQ
Sbjct: 453 TQWEDPRLQNPAITGPAVPYSREFKQ 478
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/316 (25%), Positives = 118/316 (37%), Gaps = 86/316 (27%)
Query: 35 QPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVP----MRLRK 90
+P P+ P+ + V++ GDS AL +P + PQ + RL+
Sbjct: 139 EPEPSEGGDVPEPWETISEEVNIAGDSLG--LALPPPPASPGSRTSPQELSEELSRRLQI 196
Query: 91 LPDSFFKP------PEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTP 144
PDS + EP S R S A + H P S G T+T
Sbjct: 197 TPDSNGEQFSSLIQREPSSRLRSCSVTDAVAE-------QGHLPPPSAPAGRARSSTVT- 248
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-- 202
G TP+ ++ + LP+GWE K + G+ Y++NH ++TTTW P
Sbjct: 249 ----GGEEPTPSVAYVHTTP-------GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM 297
Query: 203 ------------------------RKAMLSQMNVT--AP----TSPPVQQNMMNSASGP- 231
R LS VT AP PV++ + ++ S P
Sbjct: 298 QLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQ 357
Query: 232 --------------------LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQ 271
LP GWE + +G ++I+H KTT+W DPRL +F ++
Sbjct: 358 SPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRL--KFPVHM 415
Query: 272 RISQSAPVKQPPPLAP 287
R S PL P
Sbjct: 416 RSKTSLNPNDLGPLPP 431
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
PLP GWE+ + G YY+NH N+TT W P L
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 162 QSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQ 221
Q E+P PLP GWE + G+ Y++NH ++TT W P S M+V++ + ++
Sbjct: 64 QHQEELPPP-PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP-----SLMDVSSESDNNIR 117
Query: 222 Q 222
Q
Sbjct: 118 Q 118
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 81.6 bits (200), Expect = 1e-15
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 11/131 (8%)
Query: 137 VSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVP---LPAGWEMAKTSSGQRYFLNHI 193
V LT + +GP + + Q + P ++ LP GWE+ +G+ +F++H
Sbjct: 385 VETSQLTSSQSSAGPQSQASTSDSGQQVTQ-PSEIEQGFLPKGWEVRHAPNGRPFFIDHN 443
Query: 194 DQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKN 253
+TTTW+DPR + + + TS ++ GPLP GWE+ DG I+YINH
Sbjct: 444 TKTTTWEDPRLKIPAHLR--GKTSLDTSNDL-----GPLPPGWEERTHTDGRIFYINHNI 496
Query: 254 KTTSWLDPRLD 264
K T W DPRL+
Sbjct: 497 KRTQWEDPRLE 507
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/149 (29%), Positives = 68/149 (45%), Gaps = 26/149 (17%)
Query: 141 TLTPTGVVSGPAATPTAQHLRQS----SFE--------IPDDVPLPAGWEMAKTSSGQRY 188
T+ VS PA++ R S +FE +P LP GWE + G+ Y
Sbjct: 306 TIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSY 365
Query: 189 FLNHIDQTTTWQDPR-KAMLSQMNVTAPTSPPVQQNMMNSA-------------SGPLPD 234
+++H +TTTW P +A + +T+ S Q+ +++ G LP
Sbjct: 366 YVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPK 425
Query: 235 GWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
GWE +G ++I+H KTT+W DPRL
Sbjct: 426 GWEVRHAPNGRPFFIDHNTKTTTWEDPRL 454
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 219 PVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSA 277
P ++ ++SG LP GWE+ + G YY++H ++TT+W P + +Q S +
Sbjct: 338 PTLPVLLPTSSG-LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 395
Score = 39.3 bits (90), Expect = 0.008
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PLP GWE+ G YY+NH+++ T W P
Sbjct: 192 PLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
Score = 37.0 bits (84), Expect = 0.042
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 157 AQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP 202
A HL+Q + PLP GWE + G+ Y++NH + T W+ P
Sbjct: 181 ACHLQQQQ----EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 81.6 bits (200), Expect = 1e-15
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 11/131 (8%)
Query: 137 VSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVP---LPAGWEMAKTSSGQRYFLNHI 193
V LT + +GP + + Q + P ++ LP GWE+ +G+ +F++H
Sbjct: 732 VETSQLTSSQSSAGPQSQASTSDSGQQVTQ-PSEIEQGFLPKGWEVRHAPNGRPFFIDHN 790
Query: 194 DQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKN 253
+TTTW+DPR + + + TS ++ GPLP GWE+ DG I+YINH
Sbjct: 791 TKTTTWEDPRLKIPAHLR--GKTSLDTSNDL-----GPLPPGWEERTHTDGRIFYINHNI 843
Query: 254 KTTSWLDPRLD 264
K T W DPRL+
Sbjct: 844 KRTQWEDPRLE 854
Score = 67.0 bits (162), Expect = 4e-11
Identities = 44/149 (29%), Positives = 68/149 (45%), Gaps = 26/149 (17%)
Query: 141 TLTPTGVVSGPAATPTAQHLRQS----SFE--------IPDDVPLPAGWEMAKTSSGQRY 188
T+ VS PA++ R S +FE +P LP GWE + G+ Y
Sbjct: 653 TIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDERGRSY 712
Query: 189 FLNHIDQTTTWQDPR-KAMLSQMNVTAPTSPPVQQNMMNSA-------------SGPLPD 234
+++H +TTTW P +A + +T+ S Q+ +++ G LP
Sbjct: 713 YVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQGFLPK 772
Query: 235 GWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
GWE +G ++I+H KTT+W DPRL
Sbjct: 773 GWEVRHAPNGRPFFIDHNTKTTTWEDPRL 801
Score = 42.4 bits (98), Expect = 0.001
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 1/59 (1%)
Query: 219 PVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSA 277
P ++ ++SG LP GWE+ + G YY++H ++TT+W P + +Q S +
Sbjct: 685 PTLPVLLPTSSG-LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQS 742
Score = 39.3 bits (90), Expect = 0.008
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 231 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
PLP GWE+ G YY+NH+++ T W P
Sbjct: 539 PLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
Score = 37.0 bits (84), Expect = 0.042
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 157 AQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP 202
A HL+Q + PLP GWE + G+ Y++NH + T W+ P
Sbjct: 528 ACHLQQQQ----EPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 81.3 bits (199), Expect = 2e-15
Identities = 64/194 (32%), Positives = 88/194 (45%), Gaps = 33/194 (17%)
Query: 157 AQHLR----QSSFEIPDDVP-------LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR-- 203
AQ LR + S + P + P LP G+E T GQ YFL+ +TW DPR
Sbjct: 209 AQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
Query: 204 ----------KAMLSQMNVTAPTSPPVQQNMMNSAS-GPLPDGWEQAMTQDGEIYYINHK 252
A L + + TS P N +N GPLP GWE T G IY+++H
Sbjct: 269 SPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHN 328
Query: 253 NKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMR--LQQ 310
N+TT + DPRL MN + P QP PL P G + Q+ R +Q+
Sbjct: 329 NRTTQFTDPRL--HHIMNHQCQLKEP-SQPLPL----PSEGSLEDEELPAQRYERDLVQK 381
Query: 311 LQMEKERLRLKQQE 324
L++ + L L+Q +
Sbjct: 382 LKVLRHELSLQQPQ 395
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 75.9 bits (185), Expect = 8e-14
Identities = 72/286 (25%), Positives = 103/286 (36%), Gaps = 54/286 (18%)
Query: 20 PSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSET-----DLEALFNAVMN 74
PS P Q P P P A++ A V G+S + + V++
Sbjct: 214 PSSPSQVAARPKNTPAPKPLASEPADDT---------VNGESSSFAPTDNASVTGTPVVS 264
Query: 75 PKTANVPQTVPMRLRKLPDSFFKPPEPKSH---SRQASTDAGTAGALTPQHVRAHSSPAS 131
+ A P + P + S A ++ L P + SS A
Sbjct: 265 EENALSPNCTSTTVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAF 324
Query: 132 LQLGAVSP-GTLTPTGVVSGPAATPTA------------------QHLRQSSFEIPDDVP 172
+ P G + P SG A T T + R +++E P P
Sbjct: 325 EAAKSRQPDGCMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ--P 382
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAML-------SQMNVTAPTSPPVQQNMM 225
LP GWE + Y+++H +TTTWQ P + SQ N Q +
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYL 442
Query: 226 NSAS---------GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPR 262
SAS GPLP GWE+ + +Y++NH KTT W DPR
Sbjct: 443 YSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPR 488
Score = 69.7 bits (169), Expect = 6e-12
Identities = 34/91 (37%), Positives = 49/91 (53%), Gaps = 19/91 (20%)
Query: 172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGP 231
PLP GWE S+ + YF+NH +TT W+DPR Q + N P
Sbjct: 457 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRT-----------------QGLQNEE--P 497
Query: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDPR 262
LP+GWE T++G Y+++H +TT++ DPR
Sbjct: 498 LPEGWEIRYTREGVRYFVDHNTRTTTFKDPR 528
Score = 46.6 bits (109), Expect = 5e-05
Identities = 22/55 (40%), Positives = 32/55 (58%)
Query: 154 TPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLS 208
T T Q + + ++ PLP GWE+ T G RYF++H +TTT++DPR S
Sbjct: 479 TKTTQWEDPRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSS 533
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 75.5 bits (184), Expect = 1e-13
Identities = 70/256 (27%), Positives = 105/256 (41%), Gaps = 48/256 (18%)
Query: 11 PAPQGQGQP-PSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALF 69
P P P P+ P +G+ P + Q PAA QA P A PAG + E ++
Sbjct: 265 PNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQA-PDALPAGWE------QRELPNGRVY 317
Query: 70 NAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSP 129
N KT + +P K D P + + +T T T ++VR +
Sbjct: 318 YVDHNTKTTTWERPLPPGWEKRTD-----PRGRFYYVDHNTRTTTWQRPTAEYVRNYEQW 372
Query: 130 ASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPL---PAGWEMAKTSSGQ 186
S + + G + + L QSS D PL P GWE + +G+
Sbjct: 373 QSQR------------NQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEK-RQDNGR 419
Query: 187 RYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEI 246
Y++NH +TT W+DPR +Q + P PP GWE T +G
Sbjct: 420 VYYVNHNTRTTQWEDPR----TQGMIQEPALPP---------------GWEMKYTSEGVR 460
Query: 247 YYINHKNKTTSWLDPR 262
Y+++H +TT++ DPR
Sbjct: 461 YFVDHNTRTTTFKDPR 476
Score = 61.2 bits (147), Expect = 2e-09
Identities = 59/250 (23%), Positives = 89/250 (35%), Gaps = 62/250 (24%)
Query: 12 APQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNA 71
AP+ + QPPS G + A A T A G + H + + L N
Sbjct: 174 APENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANG 233
Query: 72 VMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPAS 131
+N + P + P EP S T+ P V + + S
Sbjct: 234 TVNDE---------------PTTATDPEEP-------SVVGVTSPPAAPLSVTPNPNTTS 271
Query: 132 LQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLN 191
L P TP G + + ++ + PD LPAGWE + +G+ Y+++
Sbjct: 272 L------PAPATPA---EGEEPSTSGTQQLPAAAQAPD--ALPAGWEQRELPNGRVYYVD 320
Query: 192 HIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINH 251
H +TTTW+ P LP GWE+ G YY++H
Sbjct: 321 HNTKTTTWERP-----------------------------LPPGWEKRTDPRGRFYYVDH 351
Query: 252 KNKTTSWLDP 261
+TT+W P
Sbjct: 352 NTRTTTWQRP 361
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 38/109 (34%)
Query: 194 DQTTTWQDPRKAMLSQMNVTAPTSPPVQ---------------------------QNMMN 226
D+ TT DP + S + VT+P + P+ Q +
Sbjct: 237 DEPTTATDPEEP--SVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPA 294
Query: 227 SASGP--LPDGWEQAMTQDGEIYYINHKNKTTSWLDP-------RLDPR 266
+A P LP GWEQ +G +YY++H KTT+W P R DPR
Sbjct: 295 AAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPR 343
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 75.5 bits (184), Expect = 1e-13
Identities = 60/182 (32%), Positives = 82/182 (45%), Gaps = 35/182 (19%)
Query: 157 AQHLR----QSSFEIPDDVP-------LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKA 205
AQ LR + S + P + P LP G+E T GQ YFL+ +TW DPR
Sbjct: 209 AQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRI- 267
Query: 206 MLSQMNVTAPTSPPVQQNMMNSAS-GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLD 264
P N +N GPLP GWE T G IY+++H N+TT + DPRL
Sbjct: 268 -------------PRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL- 313
Query: 265 PRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMR--LQQLQMEKERLRLKQ 322
MN + P QP PL P G + Q+ R +Q+L++ + L L+Q
Sbjct: 314 -HHIMNHQCQLKEP-SQPLPL----PSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQ 367
Query: 323 QE 324
+
Sbjct: 368 PQ 369
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 74.3 bits (181), Expect = 2e-13
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 19/91 (20%)
Query: 172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGP 231
PLP GWE S+G+ YF+NH + T W+DPR Q +N P
Sbjct: 398 PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRS-----------------QGQLNEK--P 438
Query: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDPR 262
LP+GWE T DG Y+++H +TT+++DPR
Sbjct: 439 LPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
Score = 70.9 bits (172), Expect = 3e-12
Identities = 46/174 (26%), Positives = 70/174 (40%), Gaps = 49/174 (28%)
Query: 98 PPEPK-------SHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSG 150
PP P+ S S + +D + G+L P + ++S GA S G + P + G
Sbjct: 220 PPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSE-----GATS-GLIIPLTISGG 273
Query: 151 PAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQM 210
P PLP GWE G+ Y+++H+++ TTW P
Sbjct: 274 SGPRP---------LNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE------- 317
Query: 211 NVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLD 264
PLP GWE+ + G IYY++H +TT+W P L+
Sbjct: 318 --------------------PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLE 351
Score = 41.6 bits (96), Expect = 0.002
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 169 DDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
++ PLP GWEM T G YF++H +TTT+ DPR
Sbjct: 435 NEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 70.9 bits (172), Expect = 3e-12
Identities = 48/185 (25%), Positives = 80/185 (43%), Gaps = 25/185 (13%)
Query: 159 HLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSP 218
++ ++ P D LP G+E T GQ YFL+ +TW DPR P
Sbjct: 241 YMSRTHLHTPPD--LPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRV-------------P 285
Query: 219 PVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAM---NQRISQ 275
N+ GPLP GWE T G +Y+++H N+TT + DPRL + Q +
Sbjct: 286 RDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLK 345
Query: 276 SAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRL-------QQLQMEKERLRLKQQELLRQ 328
+Q L P + + + Q++++ QQ Q R+ + ++E+ +
Sbjct: 346 DQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEE 405
Query: 329 AMRNI 333
+ R +
Sbjct: 406 SYRQV 410
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/235 (23%), Positives = 93/235 (39%), Gaps = 42/235 (17%)
Query: 170 DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS 229
D LP GWE +T+SG+ +LNHI +TT W+ P + + P S V +N S +
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGT 215
Query: 230 G-----------------------------------PLPDGWEQAMTQDGEIYYINHKNK 254
LP+G+EQ TQ G++Y+++ +
Sbjct: 216 NGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTG 275
Query: 255 TTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQME 314
++W DPR+ PR N + P+ P + G V ++N+ Q +L
Sbjct: 276 VSTWHDPRV-PRDLSNINCEELGPL-PPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSAN 333
Query: 315 KERLRLKQQELLRQAMRNINPSTANSPKCQELA-----LRSQLPTLEQDGGTQNP 364
+ +Q +L Q + + + +C + L +L L Q+ Q P
Sbjct: 334 LHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQP 388
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 70.9 bits (172), Expect = 3e-12
Identities = 54/208 (25%), Positives = 87/208 (41%), Gaps = 25/208 (12%)
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDV-PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
+ +++ P P+ + + D++ PLP WEMA T +G+ YF++H +TT+W DPR
Sbjct: 273 SSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPR 332
Query: 204 KAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Q + + LP GWE+ IYY++H N+ T + +P L
Sbjct: 333 CLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVL 392
Query: 264 DPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQ 323
+ K+ L Q Q QQQQ + QQ Q + E
Sbjct: 393 E--------------AKRKKQLEQQQQQ--------QQQQQQQQQQQQQQQTEEWTEDHS 430
Query: 324 ELLRQAMRNINPSTANSPKCQELALRSQ 351
L+ + N PS N +E+ L+ +
Sbjct: 431 ALVPPVIPNHPPS--NPEPAREVPLQGK 456
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/71 (43%), Positives = 43/71 (60%), Gaps = 6/71 (8%)
Query: 198 TWQDPRKAMLSQMNVTAPTSPPVQ---QNMMNSAS---GPLPDGWEQAMTQDGEIYYINH 251
T Q+ ++ + AP + P Q Q + SA GPLP+ WE A T++GE+Y+I+H
Sbjct: 262 TLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDH 321
Query: 252 KNKTTSWLDPR 262
KTTSWLDPR
Sbjct: 322 NTKTTSWLDPR 332
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 70.9 bits (172), Expect = 3e-12
Identities = 54/208 (25%), Positives = 87/208 (41%), Gaps = 25/208 (12%)
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDV-PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
+ +++ P P+ + + D++ PLP WEMA T +G+ YF++H +TT+W DPR
Sbjct: 273 SSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPR 332
Query: 204 KAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Q + + LP GWE+ IYY++H N+ T + +P L
Sbjct: 333 CLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVL 392
Query: 264 DPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQ 323
+ K+ L Q Q QQQQ + QQ Q + E
Sbjct: 393 E--------------AKRKKQLEQQQQQ--------QQQQQQQQQQQQQQQTEEWTEDHS 430
Query: 324 ELLRQAMRNINPSTANSPKCQELALRSQ 351
L+ + N PS N +E+ L+ +
Sbjct: 431 ALVPPVIPNHPPS--NPEPAREVPLQGK 456
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/71 (43%), Positives = 43/71 (60%), Gaps = 6/71 (8%)
Query: 198 TWQDPRKAMLSQMNVTAPTSPPVQ---QNMMNSAS---GPLPDGWEQAMTQDGEIYYINH 251
T Q+ ++ + AP + P Q Q + SA GPLP+ WE A T++GE+Y+I+H
Sbjct: 262 TLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDH 321
Query: 252 KNKTTSWLDPR 262
KTTSWLDPR
Sbjct: 322 NTKTTSWLDPR 332
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 70.9 bits (172), Expect = 3e-12
Identities = 54/208 (25%), Positives = 87/208 (41%), Gaps = 25/208 (12%)
Query: 145 TGVVSGPAATPTAQHLRQSSFEIPDDV-PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
+ +++ P P+ + + D++ PLP WEMA T +G+ YF++H +TT+W DPR
Sbjct: 273 SSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPR 332
Query: 204 KAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Q + + LP GWE+ IYY++H N+ T + +P L
Sbjct: 333 CLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVL 392
Query: 264 DPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQ 323
+ K+ L Q Q QQQQ + QQ Q + E
Sbjct: 393 E--------------AKRKKQLEQQQQQ--------QQQQQQQQQQQQQQQTEEWTEDHS 430
Query: 324 ELLRQAMRNINPSTANSPKCQELALRSQ 351
L+ + N PS N +E+ L+ +
Sbjct: 431 ALVPPVIPNHPPS--NPEPAREVPLQGK 456
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/71 (43%), Positives = 43/71 (60%), Gaps = 6/71 (8%)
Query: 198 TWQDPRKAMLSQMNVTAPTSPPVQ---QNMMNSAS---GPLPDGWEQAMTQDGEIYYINH 251
T Q+ ++ + AP + P Q Q + SA GPLP+ WE A T++GE+Y+I+H
Sbjct: 262 TLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDH 321
Query: 252 KNKTTSWLDPR 262
KTTSWLDPR
Sbjct: 322 NTKTTSWLDPR 332
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 70.1 bits (170), Expect = 4e-12
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 23/185 (12%)
Query: 170 DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS 229
++PLP GWE A+ G+ Y+++H ++TT+W DPR T P + + S
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRD------RYTKPLT------FADCIS 52
Query: 230 GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQS 289
LP GWE+A Y+I+H KTT DPR+ R + V Q
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQE------- 105
Query: 290 PQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALR 349
+ Q +Q RL+ Q E ++L + L + ++ S+++S E+ L+
Sbjct: 106 ---ALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEI-LK 161
Query: 350 SQLPT 354
+++ T
Sbjct: 162 AEIAT 166
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 70.1 bits (170), Expect = 4e-12
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 23/185 (12%)
Query: 170 DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS 229
++PLP GWE A+ G+ Y+++H ++TT+W DPR T P + + S
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRD------RYTKPLT------FADCIS 52
Query: 230 GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQS 289
LP GWE+A Y+I+H KTT DPR+ R + V Q
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQE------- 105
Query: 290 PQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALR 349
+ Q +Q RL+ Q E ++L + L + ++ S+++S E+ L+
Sbjct: 106 ---ALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEI-LK 161
Query: 350 SQLPT 354
+++ T
Sbjct: 162 AEIAT 166
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 70.1 bits (170), Expect = 4e-12
Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 23/185 (12%)
Query: 170 DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSAS 229
++PLP GWE A+ G+ Y+++H ++TT+W DPR T P + + S
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRD------RYTKPLT------FADCIS 52
Query: 230 GPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQS 289
LP GWE+A Y+I+H KTT DPR+ R + V Q
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQE------- 105
Query: 290 PQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALR 349
+ Q +Q RL+ Q E ++L + L + ++ S+++S E+ L+
Sbjct: 106 ---ALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEI-LK 161
Query: 350 SQLPT 354
+++ T
Sbjct: 162 AEIAT 166
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 67.8 bits (164), Expect = 2e-11
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 18/91 (19%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPL 232
LP GWE T G Y+ NH ++ T W+ P+ ++ +G L
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRV------------------AGDL 59
Query: 233 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
P GWEQ ++G++++++H NK T++LDPRL
Sbjct: 60 PYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
Score = 45.4 bits (106), Expect = 1e-04
Identities = 20/45 (44%), Positives = 28/45 (62%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTS 217
LP GWE +GQ +F++HI++ TT+ DPR A N T PT+
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
Score = 42.7 bits (99), Expect = 8e-04
Identities = 16/35 (45%), Positives = 21/35 (60%)
Query: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPR 266
LP GWE+ T+DG +YY NH + T W P+ R
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKR 52
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 67.8 bits (164), Expect = 2e-11
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 18/91 (19%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPL 232
LP GWE T G Y+ NH ++ T W+ P+ ++ +G L
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRV------------------AGDL 59
Query: 233 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
P GWEQ ++G++++++H NK T++LDPRL
Sbjct: 60 PYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
Score = 45.4 bits (106), Expect = 1e-04
Identities = 20/45 (44%), Positives = 28/45 (62%)
Query: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTS 217
LP GWE +GQ +F++HI++ TT+ DPR A N T PT+
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
Score = 42.7 bits (99), Expect = 8e-04
Identities = 16/35 (45%), Positives = 21/35 (60%)
Query: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPR 266
LP GWE+ T+DG +YY NH + T W P+ R
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKR 52
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 65.5 bits (158), Expect = 1e-10
Identities = 64/264 (24%), Positives = 94/264 (35%), Gaps = 46/264 (17%)
Query: 28 GPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMR 87
G P P +PAP Q P + +V N + A++
Sbjct: 184 GTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRN-------KSVSNMEKASI------- 229
Query: 88 LRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGV 147
+PPE + R G +TP+ A P P V
Sbjct: 230 ---------EPPEEEEEERPVVNGNGVV--VTPESSEHEDKSAGAS--GEMPSQPYPAPV 276
Query: 148 VSGPAATPT----AQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPR 203
S P + + E PD PLP WEMA T G+ YF++H +TT+W DPR
Sbjct: 277 YSQPEELKEQMDDTKPTKPEDNEEPD--PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR 334
Query: 204 KAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
A ++ PP + LP GWE+ YY++H N+ T + +P L
Sbjct: 335 LAKKAK--------PPEE-----CKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVL 381
Query: 264 DPRFAMNQRISQSAPVKQPPPLAP 287
+ + + Q + P AP
Sbjct: 382 EAKRKLQQHNMPHTELGTKPLQAP 405
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 62.0 bits (149), Expect = 1e-09
Identities = 33/90 (36%), Positives = 46/90 (51%), Gaps = 13/90 (14%)
Query: 172 PLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGP 231
PLP WEMA T +G YF++H +TTTW DPR ++ AP + G
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAK----APE---------DCEDGE 340
Query: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 261
LP GWE+ YY++H N+ T + +P
Sbjct: 341 LPYGWEKIEDPQYGTYYVDHLNQKTQFENP 370
Score = 52.8 bits (125), Expect = 7e-07
Identities = 22/40 (55%), Positives = 26/40 (65%)
Query: 224 MMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
M + PLP WE A T G IY+I+H KTT+WLDPRL
Sbjct: 287 MRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
Score = 33.1 bits (74), Expect = 0.61
Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 5/49 (10%)
Query: 169 DDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDP-----RKAMLSQMNV 212
+D LP GWE + Y+++H++Q T +++P RK L Q+ +
Sbjct: 337 EDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEI 385
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,029,018
Number of Sequences: 37866
Number of extensions: 1518299
Number of successful extensions: 26201
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 925
Number of HSP's that attempted gapping in prelim test: 12679
Number of HSP's gapped (non-prelim): 10008
length of query: 504
length of database: 18,247,518
effective HSP length: 107
effective length of query: 397
effective length of database: 14,195,856
effective search space: 5635754832
effective search space used: 5635754832
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.