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Search of human proteins with 194294519
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
(402 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 811 0.0
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 811 0.0
gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 657 0.0
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 537 e-153
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 261 1e-69
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 213 2e-55
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 209 4e-54
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 209 4e-54
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 207 2e-53
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 207 2e-53
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 207 2e-53
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 206 4e-53
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 201 7e-52
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 196 3e-50
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 189 5e-48
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 188 8e-48
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 182 5e-46
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 181 1e-45
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 176 3e-44
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 168 7e-42
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 168 7e-42
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 157 2e-38
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 157 2e-38
gi|50348666 peroxisome proliferative activated receptor, alpha [... 156 3e-38
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 156 3e-38
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 154 1e-37
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 151 1e-36
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 811 bits (2094), Expect = 0.0
Identities = 402/402 (100%), Positives = 402/402 (100%)
Query: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA
Sbjct: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
Query: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE
Sbjct: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
Query: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN
Sbjct: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
Query: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED
Sbjct: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
Query: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA
Sbjct: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
Query: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP
Sbjct: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
Query: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 811 bits (2094), Expect = 0.0
Identities = 402/402 (100%), Positives = 402/402 (100%)
Query: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA
Sbjct: 46 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 105
Query: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE
Sbjct: 106 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 165
Query: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN
Sbjct: 166 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 225
Query: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED
Sbjct: 226 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 285
Query: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA
Sbjct: 286 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 345
Query: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP
Sbjct: 346 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 405
Query: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 406 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 447
>gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
Length = 387
Score = 657 bits (1695), Expect = 0.0
Identities = 339/402 (84%), Positives = 341/402 (84%), Gaps = 60/402 (14%)
Query: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA
Sbjct: 46 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 105
Query: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE
Sbjct: 106 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 165
Query: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN
Sbjct: 166 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 225
Query: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
RRSFSDRLRVT
Sbjct: 226 RRSFSDRLRVT------------------------------------------------- 236
Query: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
+ LL+TS RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA
Sbjct: 237 -VMLLETS----------RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 285
Query: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP
Sbjct: 286 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 345
Query: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 346 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 387
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 537 bits (1383), Expect = e-153
Identities = 273/398 (68%), Positives = 319/398 (80%), Gaps = 25/398 (6%)
Query: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA--HY 87
+P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G Y
Sbjct: 64 DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY 123
Query: 88 ICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSL 147
C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ + S
Sbjct: 124 ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQ 183
Query: 148 PP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNRRSF 184
P ++S P P QL+ Q MI++LVAAQ QCN+RSF
Sbjct: 184 SPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSF 243
Query: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244
SD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQIAL
Sbjct: 244 SDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIAL 303
Query: 245 LKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNEL 304
LK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L
Sbjct: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363
Query: 305 QLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLM 364
L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLM
Sbjct: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423
Query: 365 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 424 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 261 bits (666), Expect = 1e-69
Identities = 152/390 (38%), Positives = 214/390 (54%), Gaps = 17/390 (4%)
Query: 18 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 77
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
Query: 78 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ 137
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q + K+L++
Sbjct: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
Query: 138 EEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSF---SDRLRVTPWP 194
++ A T S + L Q++ EK Q F S + P
Sbjct: 212 VKQHADQTV---NEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE 268
Query: 195 MAPDPHSRE-ARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVM 253
+ E + ++ F TE+A VQ +V+F K+LPGF L EDQIALLK SA+E M
Sbjct: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
Query: 254 LLETSRRYN---PGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 310
L ++ +N P S E +G+ E+I P+F F +++ EL++ E
Sbjct: 329 FLRSAEIFNKKLPSGHSDLL-------EERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
Query: 311 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 370
+ALL AI I S DR ++D+ VE+LQ ++ L IH P + F +L +L LR
Sbjct: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
Query: 371 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 400
T + H+E + + R+ D K PLL EIWDV
Sbjct: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 213 bits (543), Expect = 2e-55
Identities = 126/399 (31%), Positives = 212/399 (53%), Gaps = 28/399 (7%)
Query: 4 SAGGTAGVGLEA---AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
+ GG+ GLE+ +P +L + + E+ P P P++ + C VC DK+
Sbjct: 29 ATGGSCFAGLESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVY--KPCFVCNDKS 86
Query: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
SG+HY V SCEGCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +
Sbjct: 87 SGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSK 146
Query: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
E V ++ + K++K + ++ +LSP+ +E+L+ + +
Sbjct: 147 EAVRNDRNKKKKEVKEEGSPDSY----------------ELSPQ----LEELITKVSKAH 186
Query: 181 RRSFSDRLRVTPWPM-APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRE 239
+ +F ++ + + H + + F+ELA + +IV+FAK+LPGF LS
Sbjct: 187 QETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIA 246
Query: 240 DQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSR 299
DQI LLK + +++++L RY P +++TF + NR AG + +F F+
Sbjct: 247 DQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFAG 305
Query: 300 AMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMF 359
+ L+++D E LL AI + DR ++++ +V++LQ +EAL Y P MF
Sbjct: 306 QLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMF 365
Query: 360 PRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 397
PRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 366 PRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 52 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 111
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 112 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 146
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 147 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 184
P S Q P + G + + + + SF
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 245 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 303
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 304 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 361
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 362 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 398
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 52 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 111
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 112 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 146
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 147 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 184
P S Q P + G + + + + SF
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 245 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 303
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 304 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 361
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 362 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 398
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 37 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 93
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 94 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 153
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 154 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 206
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 207 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 266
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 267 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 326
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 327 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 386
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 387 --DKKLPPLLSEIWD 399
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 37 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 93
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 94 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 153
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 154 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 206
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 207 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 266
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 267 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 326
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 327 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 386
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 387 --DKKLPPLLSEIWD 399
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 37 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 93
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 94 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 153
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 154 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 206
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 207 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 266
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 267 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 326
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 327 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 386
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 387 --DKKLPPLLSEIWD 399
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 12 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 71
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 72 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 131
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 132 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 191
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
Query: 192 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 250
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
Query: 251 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 310
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
Query: 311 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 370
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
Query: 371 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 402
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 12 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 71
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 72 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 131
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 132 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 191
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
Query: 192 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 250
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
Query: 251 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 310
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
Query: 311 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 370
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
Query: 371 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 402
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 207 bits (526), Expect = 2e-53
Identities = 119/367 (32%), Positives = 198/367 (53%), Gaps = 25/367 (6%)
Query: 33 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 92
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y CH
Sbjct: 72 EMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
Query: 93 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 152
+C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY--------- 180
Query: 153 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 211
+LSP+ +E+L+ + ++ +F ++ + + H + +
Sbjct: 181 -------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDK 229
Query: 212 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 271
F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++TF
Sbjct: 230 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 289
Query: 272 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 331
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 290 DGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 348
Query: 332 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 390
+V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++ +
Sbjct: 349 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 408
Query: 391 PPLLSEI 397
PPL+ E+
Sbjct: 409 PPLIREM 415
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 206 bits (523), Expect = 4e-53
Identities = 124/376 (32%), Positives = 201/376 (53%), Gaps = 25/376 (6%)
Query: 29 SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYI 88
S EI P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y
Sbjct: 61 SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT 118
Query: 89 CHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLP 148
CH +C ++ R +CQ CRL+KC + GM +E V ++ + K++ + E +++
Sbjct: 119 CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT---- 174
Query: 149 PRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-Q 207
L+PE +IEK+ A Q+ +F ++ + R +
Sbjct: 175 ------------LTPEVGELIEKVRKAHQE----TFPALCQLGKYTTNNSSEQRVSLDID 218
Query: 208 RFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSES 267
+ F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P ++
Sbjct: 219 LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT 278
Query: 268 ITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNV 327
+TF + NR AG + +F F+ + L+++DAE LL AI + DR ++
Sbjct: 279 MTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
Query: 328 QDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ- 386
+ +V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEI 397
Query: 387 DKKLPPLLSEIWDVHE 402
+PPL+ E+ + E
Sbjct: 398 PGSMPPLIQEMLENSE 413
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 201 bits (512), Expect = 7e-52
Identities = 118/372 (31%), Positives = 201/372 (54%), Gaps = 25/372 (6%)
Query: 33 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 92
E+ P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y CH
Sbjct: 63 ELVPSPPSPLPPPRVY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
Query: 93 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 152
+C ++ R +CQ CRL+KC + GM +E V ++ + K+ +QE +++
Sbjct: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESY--------- 171
Query: 153 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 211
+++ E + EK+ A Q+ +F ++ + + H +
Sbjct: 172 -------EMTAELDDLTEKIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLDLGLWDK 220
Query: 212 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 271
F+ELA + +IV+FAK+LPGF L+ DQI LLK + +++++L RY P +++TF
Sbjct: 221 FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 280
Query: 272 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 331
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 281 DGLTLNRTQMHNAGFG-PLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPT 339
Query: 332 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 390
+V++LQ +EAL Y+ P MFP++LMK+ LR++S+ +E+V L+++ +
Sbjct: 340 KVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSM 399
Query: 391 PPLLSEIWDVHE 402
PPL+ E+ + E
Sbjct: 400 PPLIQEMLENSE 411
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 196 bits (498), Expect = 3e-50
Identities = 119/366 (32%), Positives = 195/366 (53%), Gaps = 19/366 (5%)
Query: 50 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 107
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 108 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 166
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
Query: 167 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 219
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
Query: 220 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 279
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
Query: 280 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 339
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
Query: 340 YVEALHAYVSIHHPHDRLMF-PRMLMKLVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSE 396
Y+ A YV+ H H+ F P++LMK+ LR + + H+ + ++++ + PPL E
Sbjct: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLE 403
Query: 397 IWDVHE 402
+++ E
Sbjct: 404 VFEDQE 409
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 189 bits (479), Expect = 5e-48
Identities = 128/391 (32%), Positives = 214/391 (54%), Gaps = 34/391 (8%)
Query: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 89
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
Query: 90 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 146
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
Query: 147 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--DRLRVTPWPMAPD------ 198
R + P + L+ EQ MI +L+ AQ + +FS RV+ D
Sbjct: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNY 188
Query: 199 -PHSREARQQRFA---HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVML 254
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK +A E+
Sbjct: 189 KPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQ 248
Query: 255 LETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFAL 313
L + +N +E+ T+ SY ED A G Q + P+ +F + +LQL++ E+ L
Sbjct: 249 LRFNTVFN--AETGTWECGRLSYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
Query: 314 LIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRT 371
+ AIS+FS DRP V V++LQ + L +Y+ + P R +F +++ L LR+
Sbjct: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRS 365
Query: 372 LSSVHSEQVFALRLQD--KKLPPLLSEIWDV 400
+++ H++++ LR+QD PL+ E++ +
Sbjct: 366 INAQHTQRL--LRIQDIHPFATPLMQELFGI 394
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 188 bits (477), Expect = 8e-48
Identities = 116/352 (32%), Positives = 182/352 (51%), Gaps = 23/352 (6%)
Query: 53 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 287
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+ G Q
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVGFQ 235
Query: 288 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY 347
VEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSY 295
Query: 348 V--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 397
+ P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 296 IKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 346
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 182 bits (462), Expect = 5e-46
Identities = 116/356 (32%), Positives = 182/356 (51%), Gaps = 27/356 (7%)
Query: 53 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 283
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 284 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEA 343
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 344 LHAYV--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 397
L +Y+ P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 296 LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 350
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 181 bits (459), Expect = 1e-45
Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)
Query: 50 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 107
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 108 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 166
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
Query: 167 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 219
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
Query: 220 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 279
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
Query: 280 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 339
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
Query: 340 YVEALHAYVSIHHPHDRLMF-PRMLMK 365
Y+ A YV+ H H+ F P++LMK
Sbjct: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 176 bits (447), Expect = 3e-44
Identities = 116/361 (32%), Positives = 182/361 (50%), Gaps = 32/361 (8%)
Query: 53 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 283
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 284 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQH 338
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQE 295
Query: 339 TYVEALHAYV--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSE 396
L +Y+ P DR ++ ++L L LR+++ + Q+ ++ + PLL E
Sbjct: 296 EMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQE 354
Query: 397 I 397
I
Sbjct: 355 I 355
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 168 bits (426), Expect = 7e-42
Identities = 106/315 (33%), Positives = 160/315 (50%), Gaps = 26/315 (8%)
Query: 53 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 283
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 284 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEA 343
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 344 LHAYV--SIHHPHDR 356
L +Y+ P DR
Sbjct: 296 LQSYIKGQQRRPRDR 310
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 168 bits (426), Expect = 7e-42
Identities = 106/316 (33%), Positives = 160/316 (50%), Gaps = 27/316 (8%)
Query: 53 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 112
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 113 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 172
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 173 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 227
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 228 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 287
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+ G Q
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVGFQ 235
Query: 288 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQHTYVE 342
VEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMAL 295
Query: 343 ALHAYV--SIHHPHDR 356
L +Y+ P DR
Sbjct: 296 TLQSYIKGQQRRPRDR 311
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 157 bits (397), Expect = 2e-38
Identities = 121/398 (30%), Positives = 188/398 (47%), Gaps = 30/398 (7%)
Query: 2 PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTEI--RPQKRKKGPAPKMLGNE-LCSVC 56
P A G G + PTA L P E + I P K + G+E C+VC
Sbjct: 211 PSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVC 270
Query: 57 GDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQA 116
GD AS HY V +CEGCKGFF+R+V K A YIC + CP+D R +CQ CR +KC
Sbjct: 271 GDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV 330
Query: 117 GMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQ 176
GM +K++ R + + LP + PP P ++ LV A
Sbjct: 331 GM------------VKEVVRTDSLKGRRGRLPSKPKQPPDASP------ANLLTSLVRA- 371
Query: 177 QQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQL 236
+ + +L + + PH + F +L S++ I +A+++PGF +L
Sbjct: 372 -HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAEL 430
Query: 237 SREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFE 296
S DQ LL+++ +E+ +L + R PG + F +R A+ ++I+ I
Sbjct: 431 SPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARG--FGDWIDSILA 488
Query: 297 FSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS--IHHPH 354
FSR+++ L ++ FA L A+ + DR +Q+ +VE LQ+ L +V+ P
Sbjct: 489 FSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQ 547
Query: 355 DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPP 392
R+L KL LRTL + +++F L+L+D PP
Sbjct: 548 PASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP 585
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 157 bits (397), Expect = 2e-38
Identities = 121/398 (30%), Positives = 188/398 (47%), Gaps = 30/398 (7%)
Query: 2 PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTEI--RPQKRKKGPAPKMLGNE-LCSVC 56
P A G G + PTA L P E + I P K + G+E C+VC
Sbjct: 211 PSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVC 270
Query: 57 GDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQA 116
GD AS HY V +CEGCKGFF+R+V K A YIC + CP+D R +CQ CR +KC
Sbjct: 271 GDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV 330
Query: 117 GMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQ 176
GM +K++ R + + LP + PP P ++ LV A
Sbjct: 331 GM------------VKEVVRTDSLKGRRGRLPSKPKQPPDASP------ANLLTSLVRA- 371
Query: 177 QQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQL 236
+ + +L + + PH + F +L S++ I +A+++PGF +L
Sbjct: 372 -HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAEL 430
Query: 237 SREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFE 296
S DQ LL+++ +E+ +L + R PG + F +R A+ ++I+ I
Sbjct: 431 SPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARG--FGDWIDSILA 488
Query: 297 FSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS--IHHPH 354
FSR+++ L ++ FA L A+ + DR +Q+ +VE LQ+ L +V+ P
Sbjct: 489 FSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQ 547
Query: 355 DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPP 392
R+L KL LRTL + +++F L+L+D PP
Sbjct: 548 PASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP 585
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 12 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 70
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
Query: 71 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 129
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
Query: 130 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 154
R +K K + E E A SL R +++P
Sbjct: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
Query: 155 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 214
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
Query: 215 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 274
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
Query: 275 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 332
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
Query: 333 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 390
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
Query: 391 PPLLSEIW 398
PLL EI+
Sbjct: 457 HPLLQEIY 464
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 12 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 70
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
Query: 71 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 129
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
Query: 130 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 154
R +K K + E E A SL R +++P
Sbjct: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
Query: 155 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 214
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
Query: 215 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 274
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
Query: 275 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 332
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
Query: 333 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 390
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
Query: 391 PPLLSEIW 398
PLL EI+
Sbjct: 457 HPLLQEIY 464
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 154 bits (389), Expect = 1e-37
Identities = 105/358 (29%), Positives = 180/358 (50%), Gaps = 25/358 (6%)
Query: 43 PAPKMLGNE----LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMD 98
P+P G+ LC+VCGD A+ HY V +CEGCKGFF+R+V K A Y+C + +CP+D
Sbjct: 249 PSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVD 308
Query: 99 TYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQIL 158
R +CQ CR +KC GM +K++ R + + LP + SP +
Sbjct: 309 KRRRNRCQYCRFQKCLAVGM------------VKEVVRTDSLKGRRGRLPSKPKSPQEPS 356
Query: 159 PQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIV 218
P P + +I LV A N S L + + PD Q F +L
Sbjct: 357 PPSPP--VSLISALVRAHVDSNPAMTS--LDYSRFQANPDYQMSGDDTQHIQQFYDLLTG 412
Query: 219 SVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNR 278
S++ I +A+++PGF L + DQ L +++ +E+ +L + R NP + F +R
Sbjct: 413 SMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHR 472
Query: 279 EDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQH 338
+ E+I+ I EFS + + ++ + F+ + A+++ + +R +++ +VE LQ+
Sbjct: 473 LQCVRG--FGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQN 529
Query: 339 TYVEALHAYVSIHHP--HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL 394
V L +V+ ++ + ++L KL LRTL + +++F L+L+D PP +
Sbjct: 530 KIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 151 bits (381), Expect = 1e-36
Identities = 92/318 (28%), Positives = 167/318 (52%), Gaps = 23/318 (7%)
Query: 87 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 146
Y CH +C ++ R +CQ CRL+KC + GM +E V ++ + K+ +QE +++
Sbjct: 3 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESY--- 59
Query: 147 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREAR 205
+++ E + EK+ A Q+ +F ++ + + H
Sbjct: 60 -------------EMTAELDDLTEKIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLD 102
Query: 206 QQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGS 265
+ F+ELA + +IV+FAK+LPGF L+ DQI LLK + +++++L RY P
Sbjct: 103 LGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQ 162
Query: 266 ESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRP 325
+++TF + NR AG + +F F+ + L+++D E LL AI + DR
Sbjct: 163 DTMTFSDGLTLNRTQMHNAGFG-PLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQ 221
Query: 326 NVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRL 385
++++ +V++LQ +EAL Y+ P MFP++LMK+ LR++S+ +E+V L++
Sbjct: 222 DLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 281
Query: 386 Q-DKKLPPLLSEIWDVHE 402
+ +PPL+ E+ + E
Sbjct: 282 EIPGSMPPLIQEMLENSE 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,102,729
Number of Sequences: 37866
Number of extensions: 750632
Number of successful extensions: 4181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 3797
Number of HSP's gapped (non-prelim): 243
length of query: 402
length of database: 18,247,518
effective HSP length: 105
effective length of query: 297
effective length of database: 14,271,588
effective search space: 4238661636
effective search space used: 4238661636
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.