Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 194294517
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
(447 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 902 0.0
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 811 0.0
gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 749 0.0
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 538 e-153
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 261 1e-69
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 215 6e-56
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 209 4e-54
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 209 4e-54
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 209 5e-54
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 207 2e-53
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 207 2e-53
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 207 2e-53
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 206 5e-53
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 205 8e-53
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 196 4e-50
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 189 6e-48
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 188 1e-47
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 182 5e-46
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 181 1e-45
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 176 3e-44
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 168 8e-42
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 168 8e-42
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 158 1e-38
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 158 1e-38
gi|50348666 peroxisome proliferative activated receptor, alpha [... 156 3e-38
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 156 3e-38
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 154 2e-37
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 151 1e-36
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 902 bits (2332), Expect = 0.0
Identities = 447/447 (100%), Positives = 447/447 (100%)
Query: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
Sbjct: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
Query: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
Sbjct: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
Query: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
Sbjct: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
Query: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM 240
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
Sbjct: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM 240
Query: 241 APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL 300
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
Sbjct: 241 APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL 300
Query: 301 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 360
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
Sbjct: 301 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 360
Query: 361 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 420
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
Sbjct: 361 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 420
Query: 421 HSEQVFALRLQDKKLPPLLSEIWDVHE 447
HSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 421 HSEQVFALRLQDKKLPPLLSEIWDVHE 447
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 811 bits (2094), Expect = 0.0
Identities = 402/402 (100%), Positives = 402/402 (100%)
Query: 46 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 105
MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA
Sbjct: 1 MPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
Query: 106 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 165
SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE
Sbjct: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
Query: 166 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 225
ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN
Sbjct: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
Query: 226 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 285
RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED
Sbjct: 181 RRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRED 240
Query: 286 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 345
QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA
Sbjct: 241 QIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRA 300
Query: 346 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 405
MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP
Sbjct: 301 MNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFP 360
Query: 406 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 447
RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 361 RMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402
>gi|194328806 nuclear receptor subfamily 1, group H, member 3
isoform b [Homo sapiens]
Length = 387
Score = 749 bits (1933), Expect = 0.0
Identities = 384/447 (85%), Positives = 386/447 (86%), Gaps = 60/447 (13%)
Query: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
Sbjct: 1 MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA 60
Query: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
Sbjct: 61 AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG 120
Query: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
Sbjct: 121 FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK 180
Query: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM 240
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT
Sbjct: 181 RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT---- 236
Query: 241 APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL 300
+ LL+TS
Sbjct: 237 ----------------------------------------------VMLLETS------- 243
Query: 301 ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 360
RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
Sbjct: 244 ---RRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI 300
Query: 361 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 420
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
Sbjct: 301 AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV 360
Query: 421 HSEQVFALRLQDKKLPPLLSEIWDVHE 447
HSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 361 HSEQVFALRLQDKKLPPLLSEIWDVHE 387
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 538 bits (1387), Expect = e-153
Identities = 287/461 (62%), Positives = 339/461 (73%), Gaps = 29/461 (6%)
Query: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71
P S+++ PG A S + +EE P G V G + A
Sbjct: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62
Query: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130
P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G
Sbjct: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120
Query: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189
Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ +
Sbjct: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180
Query: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226
S P ++S P P QL+ Q MI++LVAAQ QCN+
Sbjct: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240
Query: 227 RSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQ 286
RSFSD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQ
Sbjct: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300
Query: 287 IALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAM 346
IALLK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM
Sbjct: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360
Query: 347 NELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPR 406
L L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPR
Sbjct: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420
Query: 407 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 447
MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Sbjct: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 261 bits (666), Expect = 1e-69
Identities = 152/390 (38%), Positives = 214/390 (54%), Gaps = 17/390 (4%)
Query: 63 PTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 122
P L + E + + R A ++ G+ELC VCGD+ASG+HYN L+CEGCKGFF
Sbjct: 92 PAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFF 151
Query: 123 RRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ 182
RRS+ K A Y C +GG+C MD YMRRKCQECRLRKC++ GM EC+L+E Q + K+L++
Sbjct: 152 RRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKN 211
Query: 183 EEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSF---SDRLRVTPWP 239
++ A T S + L Q++ EK Q F S + P
Sbjct: 212 VKQHADQTV---NEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQE 268
Query: 240 MAPDPHSRE-ARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVM 298
+ E + ++ F TE+A VQ +V+F K+LPGF L EDQIALLK SA+E M
Sbjct: 269 ITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAM 328
Query: 299 LLETSRRYN---PGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 355
L ++ +N P S E +G+ E+I P+F F +++ EL++ E
Sbjct: 329 FLRSAEIFNKKLPSGHSDLL-------EERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381
Query: 356 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 415
+ALL AI I S DR ++D+ VE+LQ ++ L IH P + F +L +L LR
Sbjct: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441
Query: 416 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 445
T + H+E + + R+ D K PLL EIWDV
Sbjct: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 215 bits (548), Expect = 6e-56
Identities = 132/430 (30%), Positives = 223/430 (51%), Gaps = 35/430 (8%)
Query: 18 VELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA---AEPTALLTRAEPPS 74
+E + PG + A G+ + R + GG+ GLE+ +P +L + +
Sbjct: 5 METFAPGPRRLYGAAGPGAGLLRR-------ATGGSCFAGLESFAWPQPASLQSVETQST 57
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y C
Sbjct: 58 SSEEMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 115
Query: 135 HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPP 194
H +C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 116 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY------ 169
Query: 195 RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQR 253
+LSP+ +E+L+ + ++ +F ++ + + H +
Sbjct: 170 ----------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGL 215
Query: 254 FAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESI 313
+ F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++
Sbjct: 216 WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTM 275
Query: 314 TFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQ 373
TF + NR AG + +F F+ + L+++D E LL AI + DR +++
Sbjct: 276 TFSDGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 334
Query: 374 DQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-D 432
+ +V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++
Sbjct: 335 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIP 394
Query: 433 KKLPPLLSEI 442
+PPL+ E+
Sbjct: 395 GPMPPLIREM 404
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 97 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 156
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 157 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 191
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 192 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 229
P S Q P + G + + + + SF
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 230 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 289
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 290 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 348
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 349 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 406
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 407 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 443
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 209 bits (532), Expect = 4e-54
Identities = 130/400 (32%), Positives = 197/400 (49%), Gaps = 53/400 (13%)
Query: 97 LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLR 156
+C VCGD+A+GFH+N ++CEGCKGFFRRS+ + A + C G C + RR CQ CRL+
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLK 82
Query: 157 KCRQAGMREECVLSEEQIRLKK---LKRQEEE----------------------QAHATS 191
+C GM +E +L++E+++ K+ LKR+EEE AH +
Sbjct: 83 RCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKT 142
Query: 192 LPPRASSPPQILPQLSPEQLG----------------------MIEKLVAAQQQCNRRSF 229
P S Q P + G + + + + SF
Sbjct: 143 YDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSF 202
Query: 230 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 289
S+ P ++ H +L S+Q+++ FAK +PGF L+ EDQI L
Sbjct: 203 SNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVL 262
Query: 290 LKTSAIEVMLLETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNE 348
LK+SAIEV++L ++ + S T +D+ Y D KAG +E I P+ +F + +
Sbjct: 263 LKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKK 322
Query: 349 LQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH--PHDRLMFPR 406
L L++ E LL+AI I S DRP VQD +E +Q L Y+ H P L++ +
Sbjct: 323 LNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAK 382
Query: 407 MLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 443
M+ KL LR+L+ HS+Q L Q + KL PL+ E++
Sbjct: 383 MIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 82 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 138
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 139 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 198
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 199 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 251
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 252 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 311
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 312 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 371
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 372 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 431
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 432 --DKKLPPLLSEIWD 444
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 82 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 138
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 139 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 198
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 199 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 251
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 252 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 311
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 312 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 371
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 372 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 431
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 432 --DKKLPPLLSEIWD 444
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 209 bits (531), Expect = 5e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 82 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 138
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
Query: 139 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 198
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
Query: 199 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 251
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
Query: 252 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 311
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
Query: 312 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 371
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
Query: 372 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 431
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
Query: 432 --DKKLPPLLSEIWD 444
+ PPL E+++
Sbjct: 446 CPTELFPPLFLEVFE 460
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 57 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 116
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 117 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 176
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 177 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 236
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
Query: 237 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 295
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
Query: 296 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 355
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
Query: 356 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 415
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
Query: 416 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 447
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 207 bits (526), Expect = 2e-53
Identities = 127/393 (32%), Positives = 207/393 (52%), Gaps = 28/393 (7%)
Query: 57 GLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 116
G P + T++ S EI P P P++ + C VC DK+SG+HY V +CE
Sbjct: 52 GYSTPSPATIETQS---SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACE 106
Query: 117 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRL 176
GCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +E V ++ +
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 177 KKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVT 236
K++ + E +++ L+PE +IEK+ A Q+ +F ++
Sbjct: 167 KEVPKPECSESYT----------------LTPEVGELIEKVRKAHQE----TFPALCQLG 206
Query: 237 PWPMAPDPHSREARQ-QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAI 295
+ R + + F+EL+ + + V+FAKQLPGF L+ DQI LLK + +
Sbjct: 207 KYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
Query: 296 EVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAE 355
++++L RY P +++TF + NR AG + +F F+ + L+++DAE
Sbjct: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAE 325
Query: 356 FALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLR 415
LL AI + DR +++ +V+ LQ +EAL YV P MFP+MLMK+ LR
Sbjct: 326 TGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR 385
Query: 416 TLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 447
++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 386 SISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 207 bits (526), Expect = 2e-53
Identities = 119/367 (32%), Positives = 198/367 (53%), Gaps = 25/367 (6%)
Query: 78 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 137
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y CH
Sbjct: 72 EMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
Query: 138 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 197
+C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY--------- 180
Query: 198 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 256
+LSP+ +E+L+ + ++ +F ++ + + H + +
Sbjct: 181 -------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDK 229
Query: 257 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 316
F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++TF
Sbjct: 230 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 289
Query: 317 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 376
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 290 DGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 348
Query: 377 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 435
+V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++ +
Sbjct: 349 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 408
Query: 436 PPLLSEI 442
PPL+ E+
Sbjct: 409 PPLIREM 415
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 206 bits (523), Expect = 5e-53
Identities = 124/376 (32%), Positives = 201/376 (53%), Gaps = 25/376 (6%)
Query: 74 SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYI 133
S EI P P P++ + C VC DK+SG+HY V +CEGCKGFFRRS+ K Y
Sbjct: 61 SSSEEIVPSPPSPPPLPRIY--KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT 118
Query: 134 CHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLP 193
CH +C ++ R +CQ CRL+KC + GM +E V ++ + K++ + E +++
Sbjct: 119 CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT---- 174
Query: 194 PRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-Q 252
L+PE +IEK+ A Q+ +F ++ + R +
Sbjct: 175 ------------LTPEVGELIEKVRKAHQE----TFPALCQLGKYTTNNSSEQRVSLDID 218
Query: 253 RFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSES 312
+ F+EL+ + + V+FAKQLPGF L+ DQI LLK + +++++L RY P ++
Sbjct: 219 LWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDT 278
Query: 313 ITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNV 372
+TF + NR AG + +F F+ + L+++DAE LL AI + DR ++
Sbjct: 279 MTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDL 337
Query: 373 QDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ- 431
+ +V+ LQ +EAL YV P MFP+MLMK+ LR++S+ +E+V L+++
Sbjct: 338 EQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEI 397
Query: 432 DKKLPPLLSEIWDVHE 447
+PPL+ E+ + E
Sbjct: 398 PGSMPPLIQEMLENSE 413
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 205 bits (521), Expect = 8e-53
Identities = 127/414 (30%), Positives = 219/414 (52%), Gaps = 28/414 (6%)
Query: 36 SSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGN 95
SSC+L+E+A +G T ++ T++ + E+ P P P++
Sbjct: 24 SSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQS---TSSEELVPSPPSPLPPPRVY-- 78
Query: 96 ELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRL 155
+ C VC DK+SG+HY V +CEGCKGFFRRS+ K Y CH +C ++ R +CQ CRL
Sbjct: 79 KPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRL 138
Query: 156 RKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIE 215
+KC + GM +E V ++ + K+ +QE +++ +++ E + E
Sbjct: 139 QKCFEVGMSKESVRNDRNKKKKETSKQECTESY----------------EMTAELDDLTE 182
Query: 216 KLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQ 274
K+ A Q+ +F ++ + + H + F+ELA + +IV+FAK+
Sbjct: 183 KIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKR 238
Query: 275 LPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVE 334
LPGF L+ DQI LLK + +++++L RY P +++TF + NR AG
Sbjct: 239 LPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 297
Query: 335 FINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVS 394
+ +F F+ + L+++D E LL AI + DR ++++ +V++LQ +EAL Y+
Sbjct: 298 LTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIR 357
Query: 395 IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 447
P MFP++LMK+ LR++S+ +E+V L+++ +PPL+ E+ + E
Sbjct: 358 KRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 196 bits (498), Expect = 4e-50
Identities = 119/366 (32%), Positives = 195/366 (53%), Gaps = 19/366 (5%)
Query: 95 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 152
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 153 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 211
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
Query: 212 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 264
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
Query: 265 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 324
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
Query: 325 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 384
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
Query: 385 YVEALHAYVSIHHPHDRLMF-PRMLMKLVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSE 441
Y+ A YV+ H H+ F P++LMK+ LR + + H+ + ++++ + PPL E
Sbjct: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLE 403
Query: 442 IWDVHE 447
+++ E
Sbjct: 404 VFEDQE 409
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 189 bits (479), Expect = 6e-48
Identities = 128/391 (32%), Positives = 214/391 (54%), Gaps = 34/391 (8%)
Query: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 18 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 77
Query: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 78 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 131
Query: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--DRLRVTPWPMAPD------ 243
R + P + L+ EQ MI +L+ AQ + +FS RV+ D
Sbjct: 132 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNY 188
Query: 244 -PHSREARQQRFA---HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVML 299
P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK +A E+
Sbjct: 189 KPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQ 248
Query: 300 LETSRRYNPGSESITF-LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFAL 358
L + +N +E+ T+ SY ED A G Q + P+ +F + +LQL++ E+ L
Sbjct: 249 LRFNTVFN--AETGTWECGRLSYCLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVL 305
Query: 359 LIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRT 416
+ AIS+FS DRP V V++LQ + L +Y+ + P R +F +++ L LR+
Sbjct: 306 MQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRS 365
Query: 417 LSSVHSEQVFALRLQD--KKLPPLLSEIWDV 445
+++ H++++ LR+QD PL+ E++ +
Sbjct: 366 INAQHTQRL--LRIQDIHPFATPLMQELFGI 394
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 188 bits (477), Expect = 1e-47
Identities = 116/352 (32%), Positives = 182/352 (51%), Gaps = 23/352 (6%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 332
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+ G Q
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVGFQ 235
Query: 333 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAY 392
VEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ L +Y
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSY 295
Query: 393 V--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 442
+ P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 296 IKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 346
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 182 bits (462), Expect = 5e-46
Identities = 116/356 (32%), Positives = 182/356 (51%), Gaps = 27/356 (7%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 328
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 329 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEA 388
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 389 LHAYV--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 442
L +Y+ P DR ++ ++L L LR+++ + Q+ ++ + PLL EI
Sbjct: 296 LQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 350
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 181 bits (459), Expect = 1e-45
Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)
Query: 95 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 152
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
Query: 153 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 211
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
Query: 212 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 264
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
Query: 265 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 324
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
Query: 325 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 384
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
Query: 385 YVEALHAYVSIHHPHDRLMF-PRMLMK 410
Y+ A YV+ H H+ F P++LMK
Sbjct: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 176 bits (447), Expect = 3e-44
Identities = 116/361 (32%), Positives = 182/361 (50%), Gaps = 32/361 (8%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 328
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 329 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQH 383
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQE 295
Query: 384 TYVEALHAYV--SIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSE 441
L +Y+ P DR ++ ++L L LR+++ + Q+ ++ + PLL E
Sbjct: 296 EMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMM-PLLQE 354
Query: 442 I 442
I
Sbjct: 355 I 355
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 168 bits (426), Expect = 8e-42
Identities = 106/315 (33%), Positives = 160/315 (50%), Gaps = 26/315 (8%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAK---- 328
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVSPT 235
Query: 329 AGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEA 388
G QVEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALT 295
Query: 389 LHAYV--SIHHPHDR 401
L +Y+ P DR
Sbjct: 296 LQSYIKGQQRRPRDR 310
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 168 bits (426), Expect = 8e-42
Identities = 106/316 (33%), Positives = 160/316 (50%), Gaps = 27/316 (8%)
Query: 98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRK 157
C VCGD+A+G+H+N L+CEGCKGFFRR+V K C G C + RR C CRL+K
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQK 70
Query: 158 CRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKL 217
C AGMR++ +LS E + L++ K+ + RA P QLS EQ +I L
Sbjct: 71 CLDAGMRKDMILSAEALALRRAKQAQR----------RAQQTP---VQLSKEQEELIRTL 117
Query: 218 VAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQ-----QRFAHFTELAIVSVQEIVDFA 272
+ A + F ++ P P H + HF ++ V +++ F
Sbjct: 118 LGAHTRHMGTMFEQFVQFRP-PAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFT 176
Query: 273 KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 332
K LP F L EDQI+LLK +A+E+ + + + +++ Y ED A+ G Q
Sbjct: 177 KDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTIEDGARVGFQ 235
Query: 333 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFS-----ADRPNVQDQLQVERLQHTYVE 387
VEF+ +F F + +LQL + E+ LL A+++FS DRP V + ++++LQ
Sbjct: 236 VEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMAL 295
Query: 388 ALHAYV--SIHHPHDR 401
L +Y+ P DR
Sbjct: 296 TLQSYIKGQQRRPRDR 311
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 158 bits (399), Expect = 1e-38
Identities = 126/424 (29%), Positives = 199/424 (46%), Gaps = 31/424 (7%)
Query: 22 KPGAQDASSQAQGGSSCILREEARM-PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTE 78
+P A + S G S + + ++ P A G G + PTA L P E +
Sbjct: 185 QPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSG 244
Query: 79 I--RPQKRKKGPAPKMLGNE-LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICH 135
I P K + G+E C+VCGD AS HY V +CEGCKGFF+R+V K A YIC
Sbjct: 245 ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICL 304
Query: 136 SGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPR 195
+ CP+D R +CQ CR +KC GM +K++ R + + LP +
Sbjct: 305 ANKDCPVDKRRRNRCQFCRFQKCLAVGM------------VKEVVRTDSLKGRRGRLPSK 352
Query: 196 ASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFA 255
PP P ++ LV A + + +L + + PH +
Sbjct: 353 PKQPPDASP------ANLLTSLVRA--HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQ 404
Query: 256 HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITF 315
F +L S++ I +A+++PGF +LS DQ LL+++ +E+ +L + R PG + F
Sbjct: 405 QFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIF 464
Query: 316 LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQ 375
+R A+ ++I+ I FSR+++ L ++ FA L A+ + DR +Q+
Sbjct: 465 CSGLVLHRLQCARG--FGDWIDSILAFSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEP 521
Query: 376 LQVERLQHTYVEALHAYVS--IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDK 433
+VE LQ+ L +V+ P R+L KL LRTL + +++F L+L+D
Sbjct: 522 RRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDL 581
Query: 434 KLPP 437
PP
Sbjct: 582 VPPP 585
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 158 bits (399), Expect = 1e-38
Identities = 126/424 (29%), Positives = 199/424 (46%), Gaps = 31/424 (7%)
Query: 22 KPGAQDASSQAQGGSSCILREEARM-PHSAGGTAGVGLEAAEPTAL--LTRAEPPSEPTE 78
+P A + S G S + + ++ P A G G + PTA L P E +
Sbjct: 185 QPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSG 244
Query: 79 I--RPQKRKKGPAPKMLGNE-LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICH 135
I P K + G+E C+VCGD AS HY V +CEGCKGFF+R+V K A YIC
Sbjct: 245 ILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICL 304
Query: 136 SGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPR 195
+ CP+D R +CQ CR +KC GM +K++ R + + LP +
Sbjct: 305 ANKDCPVDKRRRNRCQFCRFQKCLAVGM------------VKEVVRTDSLKGRRGRLPSK 352
Query: 196 ASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFA 255
PP P ++ LV A + + +L + + PH +
Sbjct: 353 PKQPPDASP------ANLLTSLVRA--HLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQ 404
Query: 256 HFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITF 315
F +L S++ I +A+++PGF +LS DQ LL+++ +E+ +L + R PG + F
Sbjct: 405 QFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIF 464
Query: 316 LKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQ 375
+R A+ ++I+ I FSR+++ L ++ FA L A+ + DR +Q+
Sbjct: 465 CSGLVLHRLQCARG--FGDWIDSILAFSRSLHSLLVDVPAFACLSAL-VLITDRHGLQEP 521
Query: 376 LQVERLQHTYVEALHAYVS--IHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDK 433
+VE LQ+ L +V+ P R+L KL LRTL + +++F L+L+D
Sbjct: 522 RRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDL 581
Query: 434 KLPP 437
PP
Sbjct: 582 VPPP 585
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 57 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 115
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
Query: 116 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 174
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
Query: 175 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 199
R +K K + E E A SL R +++P
Sbjct: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
Query: 200 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 259
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
Query: 260 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 319
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
Query: 320 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 377
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
Query: 378 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 435
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
Query: 436 PPLLSEIW 443
PLL EI+
Sbjct: 457 HPLLQEIY 464
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 156 bits (395), Expect = 3e-38
Identities = 121/428 (28%), Positives = 190/428 (44%), Gaps = 66/428 (15%)
Query: 57 GLEAAEPTALLTRAEPPSEPT-EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSC 115
G + + T L+ A PS T + P + P+ + N C +CGDKASG+HY V +C
Sbjct: 62 GSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGAL--NIECRICGDKASGYHYGVHAC 119
Query: 116 EGCKGFFRRSV-IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQI 174
EGCKGFFRR++ +K + C C + R KCQ CR KC GM +
Sbjct: 120 EGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMP 177
Query: 175 RLKKLKRQEE-----------EQAHATSLPPR------------------------ASSP 199
R +K K + E E A SL R +++P
Sbjct: 178 RSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNP 237
Query: 200 PQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTE 259
P ++ + E L M EK + A+ N ++EA + F
Sbjct: 238 PFVIHDM--ETLCMAEKTLVAKLVAN-----------------GIQNKEAEVRIFHCCQC 278
Query: 260 LAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDF 319
++ +V E+ +FAK +PGF L DQ+ LLK E + S N + + F
Sbjct: 279 TSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGF 338
Query: 320 SYNREDFAKAGLQ--VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQ 377
+F K+ + + + P F+F+ N L+L+D++ +L +A I DRP + +
Sbjct: 339 I--TREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGH 396
Query: 378 VERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSE--QVFALRLQDKKL 435
+E++Q V L ++ +HP D +FP++L K+ LR L + H++ Q+ D L
Sbjct: 397 IEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAAL 456
Query: 436 PPLLSEIW 443
PLL EI+
Sbjct: 457 HPLLQEIY 464
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 154 bits (389), Expect = 2e-37
Identities = 105/358 (29%), Positives = 180/358 (50%), Gaps = 25/358 (6%)
Query: 88 PAPKMLGNE----LCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMD 143
P+P G+ LC+VCGD A+ HY V +CEGCKGFF+R+V K A Y+C + +CP+D
Sbjct: 249 PSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVD 308
Query: 144 TYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQIL 203
R +CQ CR +KC GM +K++ R + + LP + SP +
Sbjct: 309 KRRRNRCQYCRFQKCLAVGM------------VKEVVRTDSLKGRRGRLPSKPKSPQEPS 356
Query: 204 PQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIV 263
P P + +I LV A N S L + + PD Q F +L
Sbjct: 357 PPSPP--VSLISALVRAHVDSNPAMTS--LDYSRFQANPDYQMSGDDTQHIQQFYDLLTG 412
Query: 264 SVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNR 323
S++ I +A+++PGF L + DQ L +++ +E+ +L + R NP + F +R
Sbjct: 413 SMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHR 472
Query: 324 EDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQH 383
+ E+I+ I EFS + + ++ + F+ + A+++ + +R +++ +VE LQ+
Sbjct: 473 LQCVRG--FGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQN 529
Query: 384 TYVEALHAYVSIHHP--HDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLL 439
V L +V+ ++ + ++L KL LRTL + +++F L+L+D PP +
Sbjct: 530 KIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAI 587
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 151 bits (381), Expect = 1e-36
Identities = 92/318 (28%), Positives = 167/318 (52%), Gaps = 23/318 (7%)
Query: 132 YICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATS 191
Y CH +C ++ R +CQ CRL+KC + GM +E V ++ + K+ +QE +++
Sbjct: 3 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESY--- 59
Query: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREAR 250
+++ E + EK+ A Q+ +F ++ + + H
Sbjct: 60 -------------EMTAELDDLTEKIRKAHQE----TFPSLCQLGKYTTNSSADHRVRLD 102
Query: 251 QQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGS 310
+ F+ELA + +IV+FAK+LPGF L+ DQI LLK + +++++L RY P
Sbjct: 103 LGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQ 162
Query: 311 ESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRP 370
+++TF + NR AG + +F F+ + L+++D E LL AI + DR
Sbjct: 163 DTMTFSDGLTLNRTQMHNAGFG-PLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQ 221
Query: 371 NVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRL 430
++++ +V++LQ +EAL Y+ P MFP++LMK+ LR++S+ +E+V L++
Sbjct: 222 DLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM 281
Query: 431 Q-DKKLPPLLSEIWDVHE 447
+ +PPL+ E+ + E
Sbjct: 282 EIPGSMPPLIQEMLENSE 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,472,384
Number of Sequences: 37866
Number of extensions: 882049
Number of successful extensions: 4789
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 4384
Number of HSP's gapped (non-prelim): 293
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.