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Search of human proteins with 194239713
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194239713 laeverin [Homo sapiens]
(990 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194239713 laeverin [Homo sapiens] 2008 0.0
gi|157266300 membrane alanine aminopeptidase precursor [Homo sap... 581 e-165
gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo ... 473 e-133
gi|132814467 glutamyl aminopeptidase [Homo sapiens] 431 e-120
gi|94818891 type 1 tumor necrosis factor receptor shedding amino... 397 e-110
gi|94818901 type 1 tumor necrosis factor receptor shedding amino... 397 e-110
gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 375 e-103
gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens] 375 e-103
gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens] 373 e-103
gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens] 373 e-103
gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens] 300 3e-81
gi|4505029 leukotriene A4 hydrolase [Homo sapiens] 100 7e-21
gi|40316915 arginyl aminopeptidase [Homo sapiens] 82 2e-15
gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Ho... 70 1e-11
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 40 0.011
gi|42560231 poliovirus receptor-related 1 isoform 2 [Homo sapiens] 39 0.024
gi|51477723 testis expressed sequence 11 isoform 2 [Homo sapiens] 37 0.12
gi|51477721 testis expressed sequence 11 isoform 1 [Homo sapiens] 37 0.12
gi|239757467 PREDICTED: hypothetical protein [Homo sapiens] 35 0.45
gi|239751993 PREDICTED: hypothetical protein [Homo sapiens] 35 0.45
gi|239746476 PREDICTED: hypothetical protein [Homo sapiens] 35 0.45
gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo... 34 0.59
gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo ... 34 0.59
gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo ... 34 0.59
gi|23200025 tumor necrosis factor receptor superfamily, member 2... 34 0.59
gi|23200021 tumor necrosis factor receptor superfamily, member 2... 34 0.59
gi|4507569 tumor necrosis factor receptor superfamily, member 25... 34 0.59
gi|4504095 motilin receptor [Homo sapiens] 34 0.78
gi|122937187 glycosyltransferase 8 domain containing 4 [Homo sap... 34 0.78
gi|119226260 calcium homeostasis endoplasmic reticulum protein [... 33 1.0
>gi|194239713 laeverin [Homo sapiens]
Length = 990
Score = 2008 bits (5202), Expect = 0.0
Identities = 990/990 (100%), Positives = 990/990 (100%)
Query: 1 MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSP 60
MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSP
Sbjct: 1 MGPPSSSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSP 60
Query: 61 PLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDEL 120
PLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDEL
Sbjct: 61 PLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDEL 120
Query: 121 PAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVW 180
PAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVW
Sbjct: 121 PAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVW 180
Query: 181 FALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLE 240
FALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLE
Sbjct: 181 FALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLE 240
Query: 241 PTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTT 300
PTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTT
Sbjct: 241 PTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTT 300
Query: 301 PHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFN 360
PHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFN
Sbjct: 301 PHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFN 360
Query: 361 ISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQ 420
ISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQ
Sbjct: 361 ISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQ 420
Query: 421 WFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTR 480
WFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTR
Sbjct: 421 WFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTR 480
Query: 481 AVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQ 540
AVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQ
Sbjct: 481 AVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQ 540
Query: 541 DDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKN 600
DDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKN
Sbjct: 541 DDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKN 600
Query: 601 RTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV 660
RTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV
Sbjct: 601 RTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV 660
Query: 661 NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI 720
NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI
Sbjct: 661 NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI 720
Query: 721 IVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLA 780
IVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLA
Sbjct: 721 IVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLA 780
Query: 781 LISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWD 840
LISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWD
Sbjct: 781 LISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWD 840
Query: 841 ILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEV 900
ILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEV
Sbjct: 841 ILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVASSEV 900
Query: 901 GRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR 960
GRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR
Sbjct: 901 GRYVAKDFLVNNWQAVSKRYGTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR 960
Query: 961 VHANLQTIKNENLKNKKLSARIAAWLRRNT 990
VHANLQTIKNENLKNKKLSARIAAWLRRNT
Sbjct: 961 VHANLQTIKNENLKNKKLSARIAAWLRRNT 990
>gi|157266300 membrane alanine aminopeptidase precursor [Homo
sapiens]
Length = 967
Score = 581 bits (1497), Expect = e-165
Identities = 344/955 (36%), Positives = 529/955 (55%), Gaps = 47/955 (4%)
Query: 6 SSGFYVSRAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQK 65
+ GFY+S+++ +L L A + + L+ +Y ++ A SSP
Sbjct: 2 AKGFYISKSLGILGILLGVAAVCTIIALSVVYSQ-----------EKNKNANSSPVA--- 47
Query: 66 PTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSL 125
+ TP S+ A TT + W++ RLP L P Y + L P L P++ G
Sbjct: 48 -STTPSASATTNPASATTLDQSKA---WNRYRLPNTLKPDSYRVTLRPYLTPND--RGLY 101
Query: 126 PFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDT 185
F G + C AT +++HS + ++ + G G + +D T
Sbjct: 102 VFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPP--DIDKTELVEPT 159
Query: 186 EYMVLELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFAR 245
EY+V+ L L S YE+ F G + +DL G + + Y + R+ + +Q++ AR
Sbjct: 160 EYLVVHLKGSLVKDSQYEMDSEFEGELADDLA-GFYRSEYMEGNVRKVVATTQMQAADAR 218
Query: 246 YVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEK--EDVNGSKWTVTTFSTTPHM 303
FPCFDEPA+KA FNIT+IH ALSNM G S ED N W VT F TTP M
Sbjct: 219 KSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPN---WNVTEFHTTPKM 275
Query: 304 PTYLVAFVICDYDHVNR-TERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNIS 362
TYL+AF++ ++D+V + G IRIWAR AIA G D+ALN+TGPI +F ++
Sbjct: 276 STYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTP 335
Query: 363 YSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWF 422
Y LPK+D I LP F+ AMENWGL+ + E+ LL +P + K + V++HE+ HQWF
Sbjct: 336 YPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWF 395
Query: 423 GNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAV 482
GNLVT+ WWN++WLNEGFASY E+ +Y P ++ N ++ ++ D + +
Sbjct: 396 GNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPL 455
Query: 483 AMKVENFKT-SEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQD 541
+ T ++I ELFD +YSKGAS+ RMLS FL+E +F L SYL TF+Y N
Sbjct: 456 STPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYL 515
Query: 542 DLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEPFYLENIKNR 601
+LW H Q A++++S + LP T+++IM+ WT Q GFPVIT++ STG + QE F L+ N
Sbjct: 516 NLWDHLQEAVNNRS-IQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNV 574
Query: 602 TLLTS-NDTWIVPILWIKNGTTQPLVWL---DQSSKVFPEMQVSDSDHDWVILNLNMTGY 657
T + N WIVPI I++G Q WL + +F S S ++WV+LNLN+TGY
Sbjct: 575 TRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLF-----STSGNEWVLLNLNVTGY 629
Query: 658 YRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEE 717
YRVNYD+ W+K+ QL++D AIPVI+R Q+I+DAF+L+ + + + AL T +L EE
Sbjct: 630 YRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEE 689
Query: 718 DEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDD 777
+ + W L +L L+ + + ++Y +K YL K++ ++ I+ N + ++
Sbjct: 690 RQYMPWEAALSSLSYFKLMFDRS--EVYGPMKNYLKKQVTPLF-IHFRNNTNNWREIPEN 746
Query: 778 YLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYP-IKDVVLCYGIALGSD 836
+ S TAC G+ +C ++ LF +W+++P N +P ++ V C IA G +
Sbjct: 747 LMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGE 806
Query: 837 KEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE-TNIIEVV 895
+EWD + N T E +L A++CSK+ WILNRY+ Y ++ + T+ I +
Sbjct: 807 EEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISI 866
Query: 896 ASSEVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQF 948
++ +G+ + DF+ +NW+ + Y G+ S NLI + R +T+ ++ +L+QF
Sbjct: 867 TNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQF 921
>gi|7019561 thyrotropin-releasing hormone degrading enzyme [Homo
sapiens]
Length = 1024
Score = 473 bits (1216), Expect = e-133
Identities = 290/884 (32%), Positives = 466/884 (52%), Gaps = 52/884 (5%)
Query: 89 PPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHS 148
P PW QLRL L PLHY+L L + + F+G VN+ + C AT ++LH+
Sbjct: 132 PWEPWTQLRLSGHLKPLHYNLMLTAFME-------NFTFSGEVNVEIACRNATRYVVLHA 184
Query: 149 LFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSF 208
E+ ++ + G VPV + T+ +V+ L+ L +Y L++ +
Sbjct: 185 SRVAVEKVQL-------AEDRAFGAVPVAGFFLYPQTQVLVVVLNRTLDAQRNYNLKIIY 237
Query: 209 SGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHP 268
+ L++ +L G F + Y GERR L +Q PT AR FPCFDEP KATF I++ H
Sbjct: 238 NALIENELL-GFFRSSYVLHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQA 296
Query: 269 SYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTER-GKEI 327
+Y++LSNMP +ED W FS TP M TY +A+ IC++ + T + G +
Sbjct: 297 TYLSLSNMPVETSVFEED----GWVTDHFSQTPLMSTYYLAWAICNFTYRETTTKSGVVV 352
Query: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387
R++AR DAI GS D+AL+IT + F ED F + YSLPK D++A+P AMENWGL
Sbjct: 353 RLYARPDAIRRGSGDYALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLS 412
Query: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447
IF E +LL+P ++ V+ HEI HQWFG+LVT WW ++WL EGFA YFEF
Sbjct: 413 IFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFV 472
Query: 448 VINYFNPKL-PRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506
+Y P + F +++LH ++ D + V+ +V + ++I +FD Y KG
Sbjct: 473 GTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQEV--LQATDIDRVFDWIAYKKG 530
Query: 507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNI 566
A++ RML+ F+ +F L+ YL Y NA ++DLW A+ + I+ +
Sbjct: 531 AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDLWNTLSEALKRNGKYV---NIQEV 587
Query: 567 MDSWTHQSGFPVITLNVSTG------VMKQEPFYLENIKNRTLLTSNDT--WIVPILWI- 617
MD WT Q G+PVIT+ +T + +Q Y + K + L N++ W +P+ +
Sbjct: 588 MDQWTLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVV 647
Query: 618 ---KNGTTQPLVWLDQSSKVFPEMQVSDSDH-DWVILNLNMTGYYRVNYDKLGWKKLNQQ 673
+ +++ ++W+ S+ +++ D W++ N+N TGY+RVNYD W+ L Q
Sbjct: 648 GNRSHVSSEAIIWVSNKSE---HHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQ 704
Query: 674 LEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNLVTR 733
L ++ + + V +R LIDDAFSL++ Y+ LE+ +YL+EE + + WH L
Sbjct: 705 LIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPL 764
Query: 734 D-LVSEVNIYDIYS--LLKRYLLKRLNLIWNIYSTIIRENVLALQDDYLALISLEKLFVT 790
D L+ + Y+I++ +LK+ + L W + N +Q Y ++ +
Sbjct: 765 DKLLDRMENYNIFNEYILKQVATTYIKLGWPKNNF----NGSLVQASYQHEELRREVIML 820
Query: 791 ACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTT 850
AC G + C Q + L + W+ N IP ++D+V C G++L + W+ + + +TT
Sbjct: 821 ACSFGNKHCHQQASTLISDWISSNRNRIPLNVRDIVYCTGVSLLDEDVWEFIWMKFHSTT 880
Query: 851 NKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNET-NIIEVVASSEVGRYVAKDFL 909
EK L A++CS D +LNR + ++++ + ++I VA + GR +A F
Sbjct: 881 AVSEKKILLEALTCSDDRNLLNRLLNLSLNSEVVLDQDAIDVIIHVARNPHGRDLAWKFF 940
Query: 910 VNNWQAVSKRYGTQSLIN--LIYTIGRTVTTDLQIVELQQFFSN 951
+ W+ ++ RYG +N LI + + T+ ++ EL+ F N
Sbjct: 941 RDKWKILNTRYGEALFMNSKLISGVTEFLNTEGELKELKNFMKN 984
>gi|132814467 glutamyl aminopeptidase [Homo sapiens]
Length = 957
Score = 431 bits (1107), Expect = e-120
Identities = 280/932 (30%), Positives = 478/932 (51%), Gaps = 69/932 (7%)
Query: 58 SSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRP 117
++P P+ T PS P++ G W RLP ++ P+HYDL + P L
Sbjct: 53 TAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEE 112
Query: 118 DELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAEVRGPLSPGTGNATVGRVPVD 177
D +TG V+I++ + T L LH E R P + +V V
Sbjct: 113 DT-------YTGTVSISINLSAPTRYLWLHL-------RETRITRLPELKRPSGDQVQVR 158
Query: 178 DVWFALDTEYMVLELSEPLKPGSS---YELQLSFSGLVKEDLREGLFLNVYTDQGERRAL 234
+ EY+V+E E L P S Y L + F+G + L G + YT+ G+ +++
Sbjct: 159 RCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSL-VGFYRTTYTENGQVKSI 217
Query: 235 LASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTV 294
+A+ EPT AR FPCFDEP KAT+ I++ H Y ALSNMP + +D KWT
Sbjct: 218 VATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDD----KWTR 273
Query: 295 TTFSTTPHMPTYLVAFVICDYDHVNR-TERGKEIRIWARKDAIANGSADFALNITGPIFS 353
TTF + M TYLV F + +D V R + GK + I+ + + +A++A NIT +F
Sbjct: 274 TTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQ--KHTAEYAANITKSVFD 331
Query: 354 FLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVV 413
+ E+ F ++YSLPK D IA+P F AMENWGL+ + E+ LL +PK+ + + ++ VV
Sbjct: 332 YFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVV 391
Query: 414 SHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLP-RNEIFFSNILHNILR 472
+HE+ HQWFGN+VTM+WW ++WLNEGFAS+FEF +N+ R+++ ++L +
Sbjct: 392 AHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVL-PVQE 450
Query: 473 EDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSALKSYLKT 532
+D + + + + V EI +FD +YSKG+S+ RML ++ F + YL+
Sbjct: 451 DDSLMSSHPIIVTVTT--PDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEK 508
Query: 533 FSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEP 592
+ + NA+ D W A+++ S + +K +MD+WT Q G+PV+ +N + Q+
Sbjct: 509 YQFKNAKTSDFW----AALEEASRL----PVKEVMDTWTRQMGYPVLNVNGVKNI-TQKR 559
Query: 593 FYLENIKNRTLLTSN--DTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVIL 650
F L+ N + S+ TW +P+ W ++ T +++ + + S + ++ +
Sbjct: 560 FLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKI 619
Query: 651 NLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALEL 710
N + G+YRVNY+ W + L + K R LIDDAF+L++ ++ + AL L
Sbjct: 620 NPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNL 679
Query: 711 TKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRL-----NLIWNIYST 765
TKYL E+ + W V ++ VT + + ++Y +++ Y ++ +L WN
Sbjct: 680 TKYLKREENFLPWQRV-ISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWND--- 735
Query: 766 IIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDV 825
D++ + + AC +G + L + LF +W++ + +P ++ +
Sbjct: 736 ---------AGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVS-LPVNLRLL 785
Query: 826 VLCYGIA-LGSDKEWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF 884
V YG+ G++ W+ L Y T+ +EK +L Y ++ K+ +L+RY++ T+
Sbjct: 786 VYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLI 845
Query: 885 -TSNETNIIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSL-INLIYTIGRTVTTDLQI 942
T + +I ++ + G+ +A +++ NW + RY + + I TI T+LQ+
Sbjct: 846 KTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQL 905
Query: 943 VELQQFFSNMLE----EHQRIRVHANLQTIKN 970
+++ FF+ + E R +V L+T+KN
Sbjct: 906 WQMESFFAKYPQAGAGEKPREQV---LETVKN 934
>gi|94818891 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform b [Homo sapiens]
Length = 941
Score = 397 bits (1021), Expect = e-110
Identities = 272/934 (29%), Positives = 461/934 (49%), Gaps = 81/934 (8%)
Query: 90 PGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSL 149
P PW+++RLP +++P+HYDL + L +L F G + + + TS ++LHS
Sbjct: 46 PFPWNKIRLPEYVIPVHYDLLIHANLT-------TLTFWGTTKVEITASQPTSTIILHSH 98
Query: 150 FQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFS 209
RA +R G G + P+ + E + L EPL G Y + + ++
Sbjct: 99 HLQISRATLR----KGAGER-LSEEPLQVLEHPRQ-EQIALLAPEPLLVGLPYTVVIHYA 152
Query: 210 GLVKEDLREGLFLNVY-TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHP 268
G + E G + + Y T +GE R L ++Q EPT AR FPCFDEPA KA+F+I + P
Sbjct: 153 GNLSETFH-GFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREP 211
Query: 269 SYVALSNMPKLGQSEKEDVNGSKWTVTT-FSTTPHMPTYLVAFVICDYDHVNR-TERGKE 326
++A+SNMP + + V ++ + F T M TYLVAF+I D++ V++ T+ G +
Sbjct: 212 RHLAISNMPLV-----KSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVK 266
Query: 327 IRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGL 386
+ ++A D I AD+AL+ + F ED F+I Y LPK D+ A+P F + AMENWGL
Sbjct: 267 VSVYAVPDKI--NQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGL 324
Query: 387 MIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEF 446
+ ES LL + + K I+ V+HE+ HQWFGNLVTM WWN++WLNEGFA + EF
Sbjct: 325 TTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEF 384
Query: 447 EVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506
++ +P+L + FF + + D + V+ VEN ++I+E+FD +Y KG
Sbjct: 385 VSVSVTHPELKVGDYFFGKCF-DAMEVDALNSSHPVSTPVEN--PAQIREMFDDVSYDKG 441
Query: 507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILP------ 560
A + ML +L+ F S + YL+ SY N + +DLW D I P
Sbjct: 442 ACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLW--------DSMASICPTDGVKG 493
Query: 561 ---------------------ATIKNIMDSWTHQSGFPVITLNV-STGVMKQEPFYLENI 598
+K +M++WT Q GFP+IT+ V V ++ Y++
Sbjct: 494 MDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGS 553
Query: 599 KNRTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYY 658
+ W VP+ +I + + +L K ++ + + +W+ N+ M GYY
Sbjct: 554 DGAP--DTGYLWHVPLTFITSKSDMVHRFL---LKTKTDVLILPEEVEWIKFNVGMNGYY 608
Query: 659 RVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEED 718
V+Y+ GW L L+ A+ R LI++AF L + IE AL+L+ YL E
Sbjct: 609 IVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHET 668
Query: 719 EIIVWHTVLVNLVTR-DLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDD 777
EI+ L L+ L+ + ++ ++ + K +L++ L +I + +
Sbjct: 669 EIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLR-------DLIDKQTWTDEGS 721
Query: 778 YLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDK 837
+ +L + AC + C+Q ++ F KW + N + P+ + + + S +
Sbjct: 722 VSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGN-LSLPVDVTLAVFAVGAQSTE 780
Query: 838 EWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE-TNIIEVVA 896
WD L + Y + + EK Q+ +A+ +++ L ++ + + E I+ ++
Sbjct: 781 GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG 840
Query: 897 SSEVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLE 954
+ VG +A FL NW + +++ G+ S+ +++ +T ++ E++ FFS++ E
Sbjct: 841 RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE 900
Query: 955 EHQRIR-VHANLQTIKNENLKNKKLSARIAAWLR 987
++R V ++TI+ K +I WL+
Sbjct: 901 NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQ 934
>gi|94818901 type 1 tumor necrosis factor receptor shedding
aminopeptidase regulator isoform a [Homo sapiens]
Length = 948
Score = 397 bits (1021), Expect = e-110
Identities = 272/934 (29%), Positives = 461/934 (49%), Gaps = 81/934 (8%)
Query: 90 PGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSL 149
P PW+++RLP +++P+HYDL + L +L F G + + + TS ++LHS
Sbjct: 46 PFPWNKIRLPEYVIPVHYDLLIHANLT-------TLTFWGTTKVEITASQPTSTIILHSH 98
Query: 150 FQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFS 209
RA +R G G + P+ + E + L EPL G Y + + ++
Sbjct: 99 HLQISRATLR----KGAGER-LSEEPLQVLEHPRQ-EQIALLAPEPLLVGLPYTVVIHYA 152
Query: 210 GLVKEDLREGLFLNVY-TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHP 268
G + E G + + Y T +GE R L ++Q EPT AR FPCFDEPA KA+F+I + P
Sbjct: 153 GNLSETFH-GFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREP 211
Query: 269 SYVALSNMPKLGQSEKEDVNGSKWTVTT-FSTTPHMPTYLVAFVICDYDHVNR-TERGKE 326
++A+SNMP + + V ++ + F T M TYLVAF+I D++ V++ T+ G +
Sbjct: 212 RHLAISNMPLV-----KSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVK 266
Query: 327 IRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGL 386
+ ++A D I AD+AL+ + F ED F+I Y LPK D+ A+P F + AMENWGL
Sbjct: 267 VSVYAVPDKI--NQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGL 324
Query: 387 MIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEF 446
+ ES LL + + K I+ V+HE+ HQWFGNLVTM WWN++WLNEGFA + EF
Sbjct: 325 TTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEF 384
Query: 447 EVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKG 506
++ +P+L + FF + + D + V+ VEN ++I+E+FD +Y KG
Sbjct: 385 VSVSVTHPELKVGDYFFGKCF-DAMEVDALNSSHPVSTPVEN--PAQIREMFDDVSYDKG 441
Query: 507 ASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILP------ 560
A + ML +L+ F S + YL+ SY N + +DLW D I P
Sbjct: 442 ACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLW--------DSMASICPTDGVKG 493
Query: 561 ---------------------ATIKNIMDSWTHQSGFPVITLNV-STGVMKQEPFYLENI 598
+K +M++WT Q GFP+IT+ V V ++ Y++
Sbjct: 494 MDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGS 553
Query: 599 KNRTLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYY 658
+ W VP+ +I + + +L K ++ + + +W+ N+ M GYY
Sbjct: 554 DGAP--DTGYLWHVPLTFITSKSDMVHRFL---LKTKTDVLILPEEVEWIKFNVGMNGYY 608
Query: 659 RVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEED 718
V+Y+ GW L L+ A+ R LI++AF L + IE AL+L+ YL E
Sbjct: 609 IVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHET 668
Query: 719 EIIVWHTVLVNLVTR-DLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDD 777
EI+ L L+ L+ + ++ ++ + K +L++ L +I + +
Sbjct: 669 EIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLR-------DLIDKQTWTDEGS 721
Query: 778 YLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDK 837
+ +L + AC + C+Q ++ F KW + N + P+ + + + S +
Sbjct: 722 VSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGN-LSLPVDVTLAVFAVGAQSTE 780
Query: 838 EWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNE-TNIIEVVA 896
WD L + Y + + EK Q+ +A+ +++ L ++ + + E I+ ++
Sbjct: 781 GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG 840
Query: 897 SSEVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLE 954
+ VG +A FL NW + +++ G+ S+ +++ +T ++ E++ FFS++ E
Sbjct: 841 RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE 900
Query: 955 EHQRIR-VHANLQTIKNENLKNKKLSARIAAWLR 987
++R V ++TI+ K +I WL+
Sbjct: 901 NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQ 934
>gi|194306629 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 375 bits (963), Expect = e-103
Identities = 277/935 (29%), Positives = 442/935 (47%), Gaps = 73/935 (7%)
Query: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
PW +LRLP ++PLHYDL + P L SL F I V + AT ++LHS
Sbjct: 63 PWQELRLPSVVIPLHYDLFVHPNLT-------SLDFVASEKIEVLVSNATQFIILHSKDL 115
Query: 152 DCERAEVRGP-----LSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQL 206
+ A ++ + PG V P E + L + E L P Y + +
Sbjct: 116 EITNATLQSEEDSRYMKPGK-ELKVLSYPAH--------EQIALLVPEKLTPHLKYYVAM 166
Query: 207 SFSGLVKEDLREGLFLNVY-TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMI 265
F + + EG + + Y T GE R L + EPT AR FPCFDEP KA F+I +
Sbjct: 167 DFQAKLGDGF-EGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIR 225
Query: 266 HHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNR-TERG 324
++ALSNMPK+ E E F TT M TYLVA+++CD+ ++ T G
Sbjct: 226 RESRHIALSNMPKVKTIELE----GGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSG 281
Query: 325 KEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENW 384
++ I+A D +AL + + F E F+I Y L K D+IA+P F AMENW
Sbjct: 282 VKVSIYASPDK--RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENW 339
Query: 385 GLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYF 444
GL+ + E+ LL +PK K ++ V++HE+ HQWFGNLVTM WWN+IWL EGFA Y
Sbjct: 340 GLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYM 399
Query: 445 EFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYS 504
E +N P+L ++ +F N+ ++ +D +R ++ E ++IQE+FD +Y+
Sbjct: 400 ELIAVNATYPELQFDD-YFLNVCFEVITKDSLNSSRPISKPAET--PTQIQEMFDEVSYN 456
Query: 505 KGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWR-----------------HF 547
KGA + ML FL E F + YLK FSY NA+ DDLW H
Sbjct: 457 KGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHS 516
Query: 548 QMAIDDQSTVIL--PATIKNIMDSWTHQSGFPVITLNV-STGVMKQEPFYLENIKNR--- 601
+ L A +K +M +WT Q G P++ + + Q+ +L+ +
Sbjct: 517 DPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE 576
Query: 602 -TLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV 660
L W +P+ + + + + +S ++ S WV N++ GYY V
Sbjct: 577 WRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTS---WVKFNVDSNGYYIV 633
Query: 661 NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI 720
+Y+ GW +L QL ++ + R+ LI D F L + ++ AL++T YL E
Sbjct: 634 HYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS 693
Query: 721 IVWHTVLVNLVT-RDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYL 779
L L + ++ NI DI LKRYLL+ + + S + +V D +
Sbjct: 694 PALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVW----DRM 749
Query: 780 ALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEW 839
+L KL AC L C+Q + ELF++W++ ++ P + + Y + + W
Sbjct: 750 LRSALLKL---ACDLNHAPCIQKAAELFSQWME-SSGKLNIPTDVLKIVYSVGAQTTAGW 805
Query: 840 DILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF-TSNETNIIEVVASS 898
+ LL Y + + E+ ++ YA+S SK L + +E + T N ++ +A
Sbjct: 806 NYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARR 865
Query: 899 EVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEH 956
G+ +A DF+ NW + K++ G+ + +I ++ ++ E++ FF ++ +
Sbjct: 866 PKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQG 925
Query: 957 QRIRVHANLQTIKNENLK-NKKLSARIAAWLRRNT 990
+ + + +N+K +K + WL NT
Sbjct: 926 SHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|11641261 endoplasmic reticulum aminopeptidase 2 [Homo sapiens]
Length = 960
Score = 375 bits (963), Expect = e-103
Identities = 277/935 (29%), Positives = 442/935 (47%), Gaps = 73/935 (7%)
Query: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
PW +LRLP ++PLHYDL + P L SL F I V + AT ++LHS
Sbjct: 63 PWQELRLPSVVIPLHYDLFVHPNLT-------SLDFVASEKIEVLVSNATQFIILHSKDL 115
Query: 152 DCERAEVRGP-----LSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQL 206
+ A ++ + PG V P E + L + E L P Y + +
Sbjct: 116 EITNATLQSEEDSRYMKPGK-ELKVLSYPAH--------EQIALLVPEKLTPHLKYYVAM 166
Query: 207 SFSGLVKEDLREGLFLNVY-TDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMI 265
F + + EG + + Y T GE R L + EPT AR FPCFDEP KA F+I +
Sbjct: 167 DFQAKLGDGF-EGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIR 225
Query: 266 HHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNR-TERG 324
++ALSNMPK+ E E F TT M TYLVA+++CD+ ++ T G
Sbjct: 226 RESRHIALSNMPKVKTIELE----GGLLEDHFETTVKMSTYLVAYIVCDFHSLSGFTSSG 281
Query: 325 KEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENW 384
++ I+A D +AL + + F E F+I Y L K D+IA+P F AMENW
Sbjct: 282 VKVSIYASPDK--RNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENW 339
Query: 385 GLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYF 444
GL+ + E+ LL +PK K ++ V++HE+ HQWFGNLVTM WWN+IWL EGFA Y
Sbjct: 340 GLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYM 399
Query: 445 EFEVINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYS 504
E +N P+L ++ +F N+ ++ +D +R ++ E ++IQE+FD +Y+
Sbjct: 400 ELIAVNATYPELQFDD-YFLNVCFEVITKDSLNSSRPISKPAET--PTQIQEMFDEVSYN 456
Query: 505 KGASMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWR-----------------HF 547
KGA + ML FL E F + YLK FSY NA+ DDLW H
Sbjct: 457 KGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHS 516
Query: 548 QMAIDDQSTVIL--PATIKNIMDSWTHQSGFPVITLNV-STGVMKQEPFYLENIKNR--- 601
+ L A +K +M +WT Q G P++ + + Q+ +L+ +
Sbjct: 517 DPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPE 576
Query: 602 -TLLTSNDTWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRV 660
L W +P+ + + + + +S ++ S WV N++ GYY V
Sbjct: 577 WRALQERYLWHIPLTYSTSSSNVIHRHILKSKTDTLDLPEKTS---WVKFNVDSNGYYIV 633
Query: 661 NYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEI 720
+Y+ GW +L QL ++ + R+ LI D F L + ++ AL++T YL E
Sbjct: 634 HYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS 693
Query: 721 IVWHTVLVNLVT-RDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVLALQDDYL 779
L L + ++ NI DI LKRYLL+ + + S + +V D +
Sbjct: 694 PALLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVW----DRM 749
Query: 780 ALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDKEW 839
+L KL AC L C+Q + ELF++W++ ++ P + + Y + + W
Sbjct: 750 LRSALLKL---ACDLNHAPCIQKAAELFSQWME-SSGKLNIPTDVLKIVYSVGAQTTAGW 805
Query: 840 DILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAISTSPF-TSNETNIIEVVASS 898
+ LL Y + + E+ ++ YA+S SK L + +E + T N ++ +A
Sbjct: 806 NYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARR 865
Query: 899 EVGRYVAKDFLVNNWQAVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEH 956
G+ +A DF+ NW + K++ G+ + +I ++ ++ E++ FF ++ +
Sbjct: 866 PKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFESLEAQG 925
Query: 957 QRIRVHANLQTIKNENLK-NKKLSARIAAWLRRNT 990
+ + + +N+K +K + WL NT
Sbjct: 926 SHLDIFQTVLETITKNIKWLEKNLPTLRTWLMVNT 960
>gi|61742777 leucyl/cystinyl aminopeptidase isoform 1 [Homo sapiens]
Length = 1025
Score = 373 bits (957), Expect = e-103
Identities = 270/911 (29%), Positives = 449/911 (49%), Gaps = 79/911 (8%)
Query: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
PW Q+RLP +VPL Y+L L P L S+ F G V I+V+ T ++LHS
Sbjct: 162 PWAQIRLPTAVVPLRYELSLHPNLT-------SMTFRGSVTISVQALQVTWNIILHSTGH 214
Query: 152 DCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEY---MVLELSEPLKPGSSYELQLSF 208
+ R +S A + L+ Y + + E L G +Y L++ +
Sbjct: 215 NISRVTFMSAVSSQEKQAEI-----------LEYAYHGQIAIVAPEALLAGHNYTLKIEY 263
Query: 209 SGLVKEDLREGLFLNVYTDQG-ERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHH 267
S + G + YTD+ E++ A+Q EP AR FPCFDEPA KATF I +I
Sbjct: 264 SANISSSYY-GFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRD 322
Query: 268 PSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEI 327
Y ALSNMPK +D FS + M TYLVAF++ + ++++ G +
Sbjct: 323 EQYTALSNMPKKSSVVLDD----GLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLV 378
Query: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387
I+A + I G +AL T + F ++ F I Y L K D++A+P F+ AMENWGL+
Sbjct: 379 SIYAVPEKI--GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLL 436
Query: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447
F E LL + + L++ +++HE+ HQWFGNLVTM WWN++WLNEGFA++ E+
Sbjct: 437 TFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYF 496
Query: 448 VINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGA 507
+ +L E F + +++D + ++ V++ + +I+E+FD +Y KG+
Sbjct: 497 SLEKIFKELSSYEDFL-DARFKTMKKDSLNSSHPISSSVQS--SEQIEEMFDSLSYFKGS 553
Query: 508 SMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIM 567
S+ ML +L+E +F A+ YL SY++ + DDLW F + V K +M
Sbjct: 554 SLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDV------KRMM 607
Query: 568 DSWTHQSGFPVITLNVSTGVM--KQEPFYLENIKNRTLLTSNDT---WIVPILWIKNGTT 622
+WT Q GFP++T+ + +QE F+L N+K + +DT W +P+ ++ G
Sbjct: 608 KTWTLQKGFPLVTVQKKGKELFIQQERFFL-NMKPE--IQPSDTSYLWHIPLSYVTEGRN 664
Query: 623 ----QPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDP 678
Q + LD+ S V + + WV +N+NM GYY V+Y W+ L QL+ +P
Sbjct: 665 YSKYQSVSLLDKKSGVINLTE----EVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP 720
Query: 679 KAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEII-VWHTVLVNLVTRDLVS 737
+ R LI++ F L+ + ++ A +L YL E+ + + + +L+
Sbjct: 721 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE 780
Query: 738 EVNIYDIYSLLKRYLLKRL-NLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGL 796
++ D+ S L + K L N I T E ++++ AL+ AC L
Sbjct: 781 KLGYMDLASRLVTRVFKLLQNQIQQ--QTWTDEGTPSMRELRSALLEF------ACTHNL 832
Query: 797 EDCLQLSKELFAKWV-DHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEK 855
+C + +LF W+ + +P + V + + +DK W LL Y + ++ EK
Sbjct: 833 GNCSTTAMKLFDDWMASNGTQSLPTDVMTTV--FKVGAKTDKGWSFLLGKYISIGSEAEK 890
Query: 856 IQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETN-IIEVVASSEVGRYVAKDFLVNNWQ 914
++ A++ S+D L M+ +++ F + + + II V G +A DF+ NW
Sbjct: 891 NKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWN 950
Query: 915 AVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR--------VHAN 964
+ +++ G+ ++ N++ +T + E+Q FF N E R+R + N
Sbjct: 951 KLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLN 1010
Query: 965 LQTIKNENLKN 975
+Q ++ +NLK+
Sbjct: 1011 IQWME-KNLKS 1020
>gi|61742775 leucyl/cystinyl aminopeptidase isoform 2 [Homo sapiens]
Length = 1011
Score = 373 bits (957), Expect = e-103
Identities = 270/911 (29%), Positives = 449/911 (49%), Gaps = 79/911 (8%)
Query: 92 PWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQ 151
PW Q+RLP +VPL Y+L L P L S+ F G V I+V+ T ++LHS
Sbjct: 148 PWAQIRLPTAVVPLRYELSLHPNLT-------SMTFRGSVTISVQALQVTWNIILHSTGH 200
Query: 152 DCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEY---MVLELSEPLKPGSSYELQLSF 208
+ R +S A + L+ Y + + E L G +Y L++ +
Sbjct: 201 NISRVTFMSAVSSQEKQAEI-----------LEYAYHGQIAIVAPEALLAGHNYTLKIEY 249
Query: 209 SGLVKEDLREGLFLNVYTDQG-ERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHH 267
S + G + YTD+ E++ A+Q EP AR FPCFDEPA KATF I +I
Sbjct: 250 SANISSSYY-GFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKIIRD 308
Query: 268 PSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEI 327
Y ALSNMPK +D FS + M TYLVAF++ + ++++ G +
Sbjct: 309 EQYTALSNMPKKSSVVLDD----GLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLV 364
Query: 328 RIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387
I+A + I G +AL T + F ++ F I Y L K D++A+P F+ AMENWGL+
Sbjct: 365 SIYAVPEKI--GQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLL 422
Query: 388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFE 447
F E LL + + L++ +++HE+ HQWFGNLVTM WWN++WLNEGFA++ E+
Sbjct: 423 TFREETLLYDSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYF 482
Query: 448 VINYFNPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGA 507
+ +L E F + +++D + ++ V++ + +I+E+FD +Y KG+
Sbjct: 483 SLEKIFKELSSYEDFL-DARFKTMKKDSLNSSHPISSSVQS--SEQIEEMFDSLSYFKGS 539
Query: 508 SMARMLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIM 567
S+ ML +L+E +F A+ YL SY++ + DDLW F + V K +M
Sbjct: 540 SLLLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDV------KRMM 593
Query: 568 DSWTHQSGFPVITLNVSTGVM--KQEPFYLENIKNRTLLTSNDT---WIVPILWIKNGTT 622
+WT Q GFP++T+ + +QE F+L N+K + +DT W +P+ ++ G
Sbjct: 594 KTWTLQKGFPLVTVQKKGKELFIQQERFFL-NMKPE--IQPSDTSYLWHIPLSYVTEGRN 650
Query: 623 ----QPLVWLDQSSKVFPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDP 678
Q + LD+ S V + + WV +N+NM GYY V+Y W+ L QL+ +P
Sbjct: 651 YSKYQSVSLLDKKSGVINLTE----EVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP 706
Query: 679 KAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEII-VWHTVLVNLVTRDLVS 737
+ R LI++ F L+ + ++ A +L YL E+ + + + +L+
Sbjct: 707 YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDLIYNLLE 766
Query: 738 EVNIYDIYSLLKRYLLKRL-NLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLGL 796
++ D+ S L + K L N I T E ++++ AL+ AC L
Sbjct: 767 KLGYMDLASRLVTRVFKLLQNQIQQ--QTWTDEGTPSMRELRSALLEF------ACTHNL 818
Query: 797 EDCLQLSKELFAKWV-DHPENEIPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKEEK 855
+C + +LF W+ + +P + V + + +DK W LL Y + ++ EK
Sbjct: 819 GNCSTTAMKLFDDWMASNGTQSLPTDVMTTV--FKVGAKTDKGWSFLLGKYISIGSEAEK 876
Query: 856 IQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETN-IIEVVASSEVGRYVAKDFLVNNWQ 914
++ A++ S+D L M+ +++ F + + + II V G +A DF+ NW
Sbjct: 877 NKILEALASSEDVRKLYWLMKSSLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWN 936
Query: 915 AVSKRY--GTQSLINLIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIR--------VHAN 964
+ +++ G+ ++ N++ +T + E+Q FF N E R+R + N
Sbjct: 937 KLVQKFPLGSYTIQNIVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLN 996
Query: 965 LQTIKNENLKN 975
+Q ++ +NLK+
Sbjct: 997 IQWME-KNLKS 1006
>gi|158937236 aminopeptidase puromycin sensitive [Homo sapiens]
Length = 919
Score = 300 bits (769), Expect = 3e-81
Identities = 258/918 (28%), Positives = 415/918 (45%), Gaps = 94/918 (10%)
Query: 97 RLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERA 156
RLP + P++Y L L P L F G++ + AT++++++ D A
Sbjct: 53 RLPADVSPINYSLCLKPDLL-------DFTFEGKLEAAAQVRQATNQIVMNCADIDIITA 105
Query: 157 EVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEP--LKPGSSYELQLSFSGLVKE 214
A G + F E + LS P L+ G+ L++ F G + +
Sbjct: 106 SY----------APEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TLKIDFVGELND 154
Query: 215 DLREGLFLNVYTD-QGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVAL 273
++ G + + YT GE R +Q E T AR FPC+DEPA+KATF+I+++ VAL
Sbjct: 155 KMK-GFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVAL 213
Query: 274 SNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVN-RTERGKEIRIWAR 332
SNM + + D F+ TP M TYLVAFV+ +YD V R++ G +R++
Sbjct: 214 SNMNVIDRKPYPD--DENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTP 271
Query: 333 KDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLMIFDES 392
G FAL + F +D FN+ Y LPK D+IA+ F AMENWGL+ + E+
Sbjct: 272 VGKAEQGK--FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRET 329
Query: 393 GLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYF 452
LL++PK+ + + ++ VV HE+ HQWFGNLVTM WW ++WLNEGFAS+ E+ +++
Sbjct: 330 ALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHC 389
Query: 453 NPKLPRNEIFFSNILHNILR-EDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMAR 511
P +I+ + + R ++ + + ++V SE+ E+FD +YSKGAS+ R
Sbjct: 390 ---FPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIR 446
Query: 512 MLSCFLNEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWT 571
ML ++ + F + YL F NA +DLW + A I +M++WT
Sbjct: 447 MLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASG--------KPIAAVMNTWT 498
Query: 572 HQSGFPVITLNVSTGVMKQEPFYLENIKNRTLLTSND-------TWIVPILWIKN---GT 621
Q GFP+I + + E L + + W+VPI +
Sbjct: 499 KQMGFPLIYVEAE----QVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQ 554
Query: 622 TQPLVWLDQSSKVFPEMQV---SDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDP 678
+ + +D+ PEM V + WV LNL G+YR Y + L +
Sbjct: 555 AKLKILMDK-----PEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIR--D 607
Query: 679 KAIPVIHRLQLIDDAFSLSKNNYIEIETALELTKYLAEEDEIIVWHTVLVNL-VTRDLVS 737
++P + RL L +D FSL++ I L++ + E VW + NL + L+S
Sbjct: 608 LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLS 667
Query: 738 EVNIYDIYSLLKRYLLKRL--NLIWNIYSTIIRENVLALQDDYLALISLEKLFVTACWLG 795
+ Y+ + + + L W+ E L D L + L KL
Sbjct: 668 HTDFYEEIQEFVKDVFSPIGERLGWDPKP---GEGHL---DALLRGLVLGKLGKAGHKAT 721
Query: 796 LEDCLQLSKELFAKWVDHPENE--IPYPIKDVVLCYGIALGSDKEWDILLNTYTNTTNKE 853
LE+ + ++ DH E + + ++ V + G DI+L + +E
Sbjct: 722 LEEARR-------RFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQE 774
Query: 854 EKIQLAYAMSCSKDPWILNRYMEYAISTSPFTSNETNIIEVVA-SSEVGRYVAKDFLVNN 912
EK ++ + + P ++ + + +A+S + ++I VA S+ GR A F+ +N
Sbjct: 775 EKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDN 834
Query: 913 WQAVSKRYGTQSLIN-LIYTIGRTVTTDLQIVELQQFFSNMLEEHQRIRVHANLQTIKNE 971
W+ + RY LI+ LI D E++ FF E H +Q
Sbjct: 835 WEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFF----ESHPAPSAERTIQQCCEN 890
Query: 972 NLKNKKLSARIAAWLRRN 989
L N AAWL+R+
Sbjct: 891 ILLN-------AAWLKRD 901
>gi|4505029 leukotriene A4 hydrolase [Homo sapiens]
Length = 611
Score = 100 bits (249), Expect = 7e-21
Identities = 100/397 (25%), Positives = 158/397 (39%), Gaps = 27/397 (6%)
Query: 190 LELSEPLKPGSSYELQLSFSGLVKEDLREGLFLNVYTDQGERRALLASQLEPTFARYVFP 249
+E+S P+ + E+ + S +L G+ L SQ + R + P
Sbjct: 87 MEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILP 146
Query: 250 CFDEPALKATFNITMIHHPSYVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVA 309
C D P++K T+ + VAL M + E D + F +P YL+A
Sbjct: 147 CQDTPSVKLTYTAEVSVPKELVAL--MSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIA 204
Query: 310 FVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTD 369
V+ + + G +W+ K+ + + +F+ T + EDL Y + D
Sbjct: 205 LVV---GALESRQIGPRTLVWSEKEQVEKSAYEFSE--TESMLKIAEDLGG-PYVWGQYD 258
Query: 370 IIALP-SFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTM 428
++ LP SF MEN + F LL K +S V++HEI H W GNLVT
Sbjct: 259 LLVLPPSFPYGGMEN-PCLTFVTPTLLAGDKS--------LSNVIAHEISHSWTGNLVTN 309
Query: 429 NWWNNIWLNEGFASYFEFEVI-NYFNPKLPR-NEIFFSNILHNILREDHALVTRAVAMKV 486
W++ WLNEG Y E + F K N + L N ++ T V
Sbjct: 310 KTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGE--THPFTKLV 367
Query: 487 ENFKTSEIQELFDIFTYSKGASMARMLSCFL-NEHLFVSALKSYLKTFSYSNAEQDDLWR 545
+ + + Y KG ++ L L +F+ LK+Y++ FSY + DD W+
Sbjct: 368 VDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDD-WK 426
Query: 546 HFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLN 582
F + +L N +W + G P I N
Sbjct: 427 DFLYSYFKDKVDVLNQVDWN---AWLYSPGLPPIKPN 460
>gi|40316915 arginyl aminopeptidase [Homo sapiens]
Length = 650
Score = 82.0 bits (201), Expect = 2e-15
Identities = 121/508 (23%), Positives = 201/508 (39%), Gaps = 60/508 (11%)
Query: 105 LHYDLELWPQLRPDELPAGSLPFTGRVNITVRCT----VATSRLLLHSLFQDCERAEVRG 160
LH L+L + P AGS +G + +RC A RL H + A R
Sbjct: 37 LHLHLDLRAEFGPPGPGAGSRGLSGTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRE 96
Query: 161 PLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSGLVKEDLREG- 219
PG+ V F+ + + + +P + ++ L++ + EG
Sbjct: 97 --RPGSEEPPAEPVSFYTQPFSHYGQALCVSFPQPCRAAERLQVLLTYR------VGEGP 148
Query: 220 --LFLNVYTDQGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALSNMP 277
+L G+++ + +Q + R FPCFD PA+K ++ + + A+
Sbjct: 149 GVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGFTAV---- 204
Query: 278 KLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIA 337
+ S E +K+ F +P+YL+A I D + E G R+WA I
Sbjct: 205 -MSASTWEKRGPNKFF---FQMCQPIPSYLIALAIGD---LVSAEVGPRSRVWAEPCLID 257
Query: 338 NGSADFALNITGPIFSFL---EDLFNISYSLPKTDIIALP-SFDNHAMENWGLMIFDESG 393
++ G I FL E LF Y + D++ +P SF MEN + F
Sbjct: 258 AAKEEY----NGVIEEFLATGEKLFG-PYVWGRYDLLFMPPSFPFGGMEN-PCLTFVTPC 311
Query: 394 LLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVIN-YF 452
LL + ++ V+ HEI H WFGNLVT W WLNEGF Y + + F
Sbjct: 312 LLAGDRS--------LADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILF 363
Query: 453 NPKLPRNEIFFSNIL----HNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGAS 508
E L +I E++ L + +K+E + + ++ Y KG
Sbjct: 364 GAAYTCLEAATGRALLRQHMDITGEENPL--NKLRVKIE--PGVDPDDTYNETPYEKGFC 419
Query: 509 MARMLSCFL-NEHLFVSALKSYLKTFSYSNAEQD---DLWRHFQMAIDDQSTVILPATIK 564
L+ + ++ F S LK+Y+ F + + D D + + + + I+P
Sbjct: 420 FVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGF-- 477
Query: 565 NIMDSWTHQSGFPVITLNVSTGVMKQEP 592
D W + G+P ++S G +P
Sbjct: 478 -EFDRWLNTPGWPPYLPDLSPGDSLMKP 504
>gi|54020718 arginyl aminopeptidase (aminopeptidase B)-like 1 [Homo
sapiens]
Length = 494
Score = 70.1 bits (170), Expect = 1e-11
Identities = 74/300 (24%), Positives = 120/300 (40%), Gaps = 31/300 (10%)
Query: 303 MPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIANGSADFALNITGPIFSFL---EDLF 359
+P YLVA V D + + G R+WA + ++ ++G + +L E L+
Sbjct: 23 VPAYLVALVAGD---LKPADIGPRSRVWAEPCLLPTATS----KLSGAVEQWLSAAERLY 75
Query: 360 NISYSLPKTDIIALP-SFDNHAMENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIG 418
Y + DI+ LP SF AMEN L S + E + V HE+
Sbjct: 76 G-PYMWGRYDIVFLPPSFPIVAMENPCLTFIISS---------ILESDEFLVIDVIHEVA 125
Query: 419 HQWFGNLVTMNWWNNIWLNEGFASYFEFEVI--NYFNPKLPRNEIFFSNILH---NILRE 473
H WFGN VT W +WL+EG A+Y + + Y F + LH +L E
Sbjct: 126 HSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGE 185
Query: 474 DHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNE-HLFVSALKSYLKT 532
D + V ++ L ++FTY KG LS + F L++Y++
Sbjct: 186 DSPVSKLQVKLE----PGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEK 241
Query: 533 FSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQEP 592
+ +++ DL F + + + W + +G P+ ++S G P
Sbjct: 242 YKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRP 301
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 40.0 bits (92), Expect = 0.011
Identities = 36/103 (34%), Positives = 44/103 (42%), Gaps = 10/103 (9%)
Query: 3 PPSSSGFYVSRAVALLLAGLVAALLLALA---VLAALYGHCER--VPPSELPGLRDLEAE 57
PP ++ VA+LL LVA LLL L VL L H + +E +
Sbjct: 1270 PPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPG 1329
Query: 58 SSPPL-----RQKPTPTPKPSSARELAVTTTPSNWRPPGPWDQ 95
S PPL Q PTPT P+ A A P+ PGP DQ
Sbjct: 1330 SKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQ 1372
>gi|42560231 poliovirus receptor-related 1 isoform 2 [Homo sapiens]
Length = 458
Score = 38.9 bits (89), Expect = 0.024
Identities = 37/110 (33%), Positives = 49/110 (44%), Gaps = 14/110 (12%)
Query: 14 AVALLLAGLVAALLLALAVLAA--LYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPK 71
+ A LLAG VA L+ +AVL LY ++ PP E G A + PL QKP P+P
Sbjct: 345 SAARLLAGTVAVFLILVAVLTVFFLYNRQQKSPP-ETDG-----AGTDQPLSQKPEPSPS 398
Query: 72 PSSARE----LAVTTTPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRP 117
S+ V P + D +L L P +YDL + P P
Sbjct: 399 RQSSLVPEDIQVVHLDPGRQQQQEEEDLQKLS--LQPPYYDLGVSPSYHP 446
>gi|51477723 testis expressed sequence 11 isoform 2 [Homo sapiens]
Length = 925
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 382 ENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFA 441
EN G ++ + +LL+ K++L K+ + ++H+ G Q +MNW +NI + +
Sbjct: 354 ENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAE--SMNWLHNILWRQAAS 411
Query: 442 SYFEFEVINY 451
S FEV NY
Sbjct: 412 S---FEVQNY 418
>gi|51477721 testis expressed sequence 11 isoform 1 [Homo sapiens]
Length = 940
Score = 36.6 bits (83), Expect = 0.12
Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 382 ENWGLMIFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFA 441
EN G ++ + +LL+ K++L K+ + ++H+ G Q +MNW +NI + +
Sbjct: 369 ENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAE--SMNWLHNILWRQAAS 426
Query: 442 SYFEFEVINY 451
S FEV NY
Sbjct: 427 S---FEVQNY 433
>gi|239757467 PREDICTED: hypothetical protein [Homo sapiens]
Length = 278
Score = 34.7 bits (78), Expect = 0.45
Identities = 18/46 (39%), Positives = 23/46 (50%)
Query: 28 LALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPS 73
LA AA + PS P LR A +SP +R P+P+P PS
Sbjct: 100 LAARAAAAAPRSLRKPSPSPSPSLRRRRARNSPGIRPSPSPSPSPS 145
>gi|239751993 PREDICTED: hypothetical protein [Homo sapiens]
Length = 278
Score = 34.7 bits (78), Expect = 0.45
Identities = 18/46 (39%), Positives = 23/46 (50%)
Query: 28 LALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPS 73
LA AA + PS P LR A +SP +R P+P+P PS
Sbjct: 100 LAARAAAAAPRSLRKPSPSPSPSLRRRRARNSPGIRPSPSPSPSPS 145
>gi|239746476 PREDICTED: hypothetical protein [Homo sapiens]
Length = 278
Score = 34.7 bits (78), Expect = 0.45
Identities = 18/46 (39%), Positives = 23/46 (50%)
Query: 28 LALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPS 73
LA AA + PS P LR A +SP +R P+P+P PS
Sbjct: 100 LAARAAAAAPRSLRKPSPSPSPSLRRRRARNSPGIRPSPSPSPSPS 145
>gi|114155127 regulator of G-protein signalling 3 isoform 6 [Homo
sapiens]
Length = 1198
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 4/52 (7%)
Query: 41 ERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGP 92
E P ELP +DL P Q+P P+ +P S+++ A S PPGP
Sbjct: 709 EPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSAT----SEGSPPGP 756
>gi|10864075 regulator of G-protein signalling 3 isoform 2 [Homo
sapiens]
Length = 519
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 4/52 (7%)
Query: 41 ERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGP 92
E P ELP +DL P Q+P P+ +P S+++ A S PPGP
Sbjct: 30 EPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSAT----SEGSPPGP 77
>gi|62865651 regulator of G-protein signalling 3 isoform 1 [Homo
sapiens]
Length = 917
Score = 34.3 bits (77), Expect = 0.59
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 4/52 (7%)
Query: 41 ERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGP 92
E P ELP +DL P Q+P P+ +P S+++ A S PPGP
Sbjct: 428 EPSPGQELPPGQDLPPNKDSPSGQEPAPSQEPLSSKDSAT----SEGSPPGP 475
>gi|23200025 tumor necrosis factor receptor superfamily, member 25
isoform 4 precursor [Homo sapiens]
Length = 372
Score = 34.3 bits (77), Expect = 0.59
Identities = 40/123 (32%), Positives = 47/123 (38%), Gaps = 14/123 (11%)
Query: 15 VALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQ-KPTPT---- 69
V +LLAGLV LLL A L Y HC P +EA + PP P +
Sbjct: 158 VQVLLAGLVVPLLLG-ATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTL 216
Query: 70 --PKPSSARELAVTTTPSNWRPPGPWDQLRLPP---WLVPLHYDLELWPQLRP---DELP 121
P SS + V ++W P P Q L P W L P P E P
Sbjct: 217 LAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESP 276
Query: 122 AGS 124
AGS
Sbjct: 277 AGS 279
>gi|23200021 tumor necrosis factor receptor superfamily, member 25
isoform 1 precursor [Homo sapiens]
Length = 426
Score = 34.3 bits (77), Expect = 0.59
Identities = 40/123 (32%), Positives = 47/123 (38%), Gaps = 14/123 (11%)
Query: 15 VALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQ-KPTPT---- 69
V +LLAGLV LLL A L Y HC P +EA + PP P +
Sbjct: 212 VQVLLAGLVVPLLLG-ATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTL 270
Query: 70 --PKPSSARELAVTTTPSNWRPPGPWDQLRLPP---WLVPLHYDLELWPQLRP---DELP 121
P SS + V ++W P P Q L P W L P P E P
Sbjct: 271 LAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESP 330
Query: 122 AGS 124
AGS
Sbjct: 331 AGS 333
>gi|4507569 tumor necrosis factor receptor superfamily, member 25
isoform 2 precursor [Homo sapiens]
Length = 417
Score = 34.3 bits (77), Expect = 0.59
Identities = 40/123 (32%), Positives = 47/123 (38%), Gaps = 14/123 (11%)
Query: 15 VALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQ-KPTPT---- 69
V +LLAGLV LLL A L Y HC P +EA + PP P +
Sbjct: 203 VQVLLAGLVVPLLLG-ATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTL 261
Query: 70 --PKPSSARELAVTTTPSNWRPPGPWDQLRLPP---WLVPLHYDLELWPQLRP---DELP 121
P SS + V ++W P P Q L P W L P P E P
Sbjct: 262 LAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESP 321
Query: 122 AGS 124
AGS
Sbjct: 322 AGS 324
>gi|4504095 motilin receptor [Homo sapiens]
Length = 412
Score = 33.9 bits (76), Expect = 0.78
Identities = 40/135 (29%), Positives = 48/135 (35%), Gaps = 23/135 (17%)
Query: 13 RAVALLLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEA------ESSPPLRQKP 66
R V L+A L A LL+ L G + S +PGL SSPPL
Sbjct: 153 RRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSR 212
Query: 67 TPTPKPSSARELAVTTT--PSNWRP-PGPWDQLRLPPWLVPLHYDL-------------- 109
P P P S E A RP P LR+ W+ ++ L
Sbjct: 213 APPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGR 272
Query: 110 ELWPQLRPDELPAGS 124
ELW RP PA S
Sbjct: 273 ELWSSRRPLRGPAAS 287
>gi|122937187 glycosyltransferase 8 domain containing 4 [Homo
sapiens]
Length = 443
Score = 33.9 bits (76), Expect = 0.78
Identities = 37/106 (34%), Positives = 46/106 (43%), Gaps = 17/106 (16%)
Query: 12 SRAVALLLAGLVAALLLALAVLAALYGHCERVP--------------PSELPGLRDLEAE 57
S+A ALLL L AALLLAL L A +P P+ PG L
Sbjct: 5 SKAAALLLLAL-AALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPG- 62
Query: 58 SSPPLRQKPTPTPKPSSARELAVTTTPSNWRPPGPWD-QLRLPPWL 102
+SP +R++ P P+P + R A RP P Q LPP L
Sbjct: 63 ASPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPEL 108
>gi|119226260 calcium homeostasis endoplasmic reticulum protein
[Homo sapiens]
Length = 916
Score = 33.5 bits (75), Expect = 1.0
Identities = 26/97 (26%), Positives = 37/97 (38%), Gaps = 32/97 (32%)
Query: 53 DLEAESSPPLRQKPTPTPKPSSARELAVTTTPSNWRP----------------------- 89
+ E +++PP P P P P+ A + TT P + +P
Sbjct: 348 EAEVKATPP---PPAPPPAPAPAPAIPPTTQPDDSKPPIQMPGSSEYEAPGGVQDPAAAG 404
Query: 90 ---PGPWDQL--RLPPWLVPLHYDLELWPQLRPDELP 121
PGP DQ+ PPW H + W Q +P E P
Sbjct: 405 PRGPGPHDQIPPNKPPWFDQPH-PVAPWGQQQPPEQP 440
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,973,328
Number of Sequences: 37866
Number of extensions: 1802796
Number of successful extensions: 6738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 6393
Number of HSP's gapped (non-prelim): 288
length of query: 990
length of database: 18,247,518
effective HSP length: 112
effective length of query: 878
effective length of database: 14,006,526
effective search space: 12297729828
effective search space used: 12297729828
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.