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Search of human proteins with 190014610
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190014610 transmembrane and coiled-coil domain family 1
isoform a [Homo sapiens]
(653 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190014610 transmembrane and coiled-coil domain family 1 isofo... 1268 0.0
gi|190014612 transmembrane and coiled-coil domain family 1 isofo... 1039 0.0
gi|39930343 transmembrane and coiled-coil domain family 1 isofor... 637 0.0
gi|54792740 transmembrane and coiled-coil domain family 2 [Homo ... 630 e-180
gi|188497714 transmembrane and coiled-coil domain family 3 [Homo... 427 e-119
gi|4503177 testis expressed 28 [Homo sapiens] 135 2e-31
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 54 5e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 54 5e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 54 5e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 54 5e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 54 5e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 54 5e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 54 5e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 54 5e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 47 4e-05
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 46 9e-05
gi|42794779 myosin 18A isoform b [Homo sapiens] 46 9e-05
gi|28416946 myosin 18A isoform a [Homo sapiens] 46 9e-05
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi... 46 1e-04
gi|53729363 leucine rich repeat and sterile alpha motif containi... 46 1e-04
gi|53729361 leucine rich repeat and sterile alpha motif containi... 46 1e-04
gi|53729359 leucine rich repeat and sterile alpha motif containi... 46 1e-04
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 45 3e-04
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 45 3e-04
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 44 4e-04
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 44 4e-04
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 44 4e-04
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 44 4e-04
gi|219555718 synaptonemal complex central element protein 1 isof... 44 5e-04
gi|219555716 synaptonemal complex central element protein 1 isof... 44 5e-04
>gi|190014610 transmembrane and coiled-coil domain family 1 isoform
a [Homo sapiens]
Length = 653
Score = 1268 bits (3281), Expect = 0.0
Identities = 653/653 (100%), Positives = 653/653 (100%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR
Sbjct: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS
Sbjct: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA
Sbjct: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
Query: 181 ACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQK 240
ACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQK
Sbjct: 181 ACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQK 240
Query: 241 ILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLE 300
ILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLE
Sbjct: 241 ILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLE 300
Query: 301 HYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHS 360
HYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHS
Sbjct: 301 HYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHS 360
Query: 361 AAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSE 420
AAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSE
Sbjct: 361 AAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSE 420
Query: 421 EDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF 480
EDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF
Sbjct: 421 EDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF 480
Query: 481 ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ 540
ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ
Sbjct: 481 ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ 540
Query: 541 SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVL 600
SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVL
Sbjct: 541 SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVL 600
Query: 601 LVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR 653
LVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR
Sbjct: 601 LVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR 653
>gi|190014612 transmembrane and coiled-coil domain family 1 isoform
c [Homo sapiens]
Length = 539
Score = 1039 bits (2687), Expect = 0.0
Identities = 539/539 (100%), Positives = 539/539 (100%)
Query: 115 MKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACA 174
MKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACA
Sbjct: 1 MKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACA 60
Query: 175 AAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAI 234
AAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAI
Sbjct: 61 AAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAI 120
Query: 235 AHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQ 294
AHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQ
Sbjct: 121 AHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQ 180
Query: 295 LQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSF 354
LQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSF
Sbjct: 181 LQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSF 240
Query: 355 SQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSS 414
SQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSS
Sbjct: 241 SQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSS 300
Query: 415 PKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQA 474
PKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQA
Sbjct: 301 PKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQA 360
Query: 475 RLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASME 534
RLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASME
Sbjct: 361 RLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASME 420
Query: 535 EKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILL 594
EKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILL
Sbjct: 421 EKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILL 480
Query: 595 AVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR 653
AVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR
Sbjct: 481 AVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR 539
>gi|39930343 transmembrane and coiled-coil domain family 1 isoform b
[Homo sapiens]
Length = 329
Score = 637 bits (1643), Expect = 0.0
Identities = 329/329 (100%), Positives = 329/329 (100%)
Query: 325 MHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSAD 384
MHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSAD
Sbjct: 1 MHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSAD 60
Query: 385 NIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA 444
NIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA
Sbjct: 61 NIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA 120
Query: 445 SSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYR 504
SSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYR
Sbjct: 121 SSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYR 180
Query: 505 CERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 564
CERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL
Sbjct: 181 CERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 240
Query: 565 QQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST 624
QQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST
Sbjct: 241 QQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST 300
Query: 625 LFLVVFIAFLWKHWDALFSYVERFFSSPR 653
LFLVVFIAFLWKHWDALFSYVERFFSSPR
Sbjct: 301 LFLVVFIAFLWKHWDALFSYVERFFSSPR 329
>gi|54792740 transmembrane and coiled-coil domain family 2 [Homo
sapiens]
Length = 709
Score = 630 bits (1625), Expect = e-180
Identities = 365/672 (54%), Positives = 444/672 (66%), Gaps = 63/672 (9%)
Query: 13 PDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQ 72
P+PG +S+ + +K + L ++ G GLKHLF H RRRS H Q
Sbjct: 57 PNPGPRSKPPDLKKIQQ------------LSEGSMFGHGLKHLF-HSRRRSREREHQTSQ 103
Query: 73 IQADPEPEMDLESQNACAE---------------IDGVPTHPTALNRVLQQIRVPPKMKR 117
+ + + ++ E + +P PTA NRVLQQIR P +KR
Sbjct: 104 DSQQHQQQQGMSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKR 163
Query: 118 GTSLHSRRG--------------KPEAPKGSPQINRKSGQE--MTAVMQSG--RPRSSST 159
G SLHS G E +GSP + RK+ Q+ + A++ RPRSSST
Sbjct: 164 GASLHSSSGGGSSGSSSRRTKSSSLEPQRGSPHLLRKAPQDSSLAAILHQHQCRPRSSST 223
Query: 160 TDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTD 219
TD A A A EG +++++ ++ +L+ + TDG I D
Sbjct: 224 TDTALLLADGSNVYLLAEEA-------EGIGDKVDKGDLVALSLPAGH--GDTDGPISLD 274
Query: 220 SVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQ 279
DG PDPQRTKAAI HL QKILK+TEQIKI Q ARDDNVAEYLKLAN+ADKQQ +RIKQ
Sbjct: 275 VPDGAPDPQRTKAAIDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQ 334
Query: 280 VFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKV--- 336
VFEKKNQKSAQTI QL KKLEHY R+L+E+EQNG RQPKDV RDM QGLKDVGA V
Sbjct: 335 VFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQNGPSRQPKDVLRDMQQGLKDVGANVRAG 394
Query: 337 -TGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEE 395
+GF GVV+ VKG S SQATH+A VVSKPRE ASLIRNKFGSADNI +LKD LE+
Sbjct: 395 ISGFGGGVVEGVKGSLSGLSQATHTA---VVSKPREFASLIRNKFGSADNIAHLKDPLED 451
Query: 396 GQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA-SSSKTNTLDM 454
G ++A +AL + SSPKYGS+++CSSA++ S GA S +G GA S K+N L
Sbjct: 452 GPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGSPKSNALYG 511
Query: 455 QSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLND 514
DALL E++EI+E Q+ LE+S E LK QRDY+ + Q LQEERYR ERLEEQLND
Sbjct: 512 APGNLDALLEELREIKEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLND 571
Query: 515 LTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQL 574
LTELHQNE+ NLKQELASMEEK+AYQSYERARDIQEA+E+C TR++K+ELQQQQQQVVQL
Sbjct: 572 LTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQL 631
Query: 575 EGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFL 634
EG+ENA AR LLGK IN++LA+MAVLLVFVST+AN + PLMKTR R ST LV+ + L
Sbjct: 632 EGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLL 691
Query: 635 WKHWDALFSYVE 646
WKHWD+L +E
Sbjct: 692 WKHWDSLTYLLE 703
>gi|188497714 transmembrane and coiled-coil domain family 3 [Homo
sapiens]
Length = 477
Score = 427 bits (1098), Expect = e-119
Identities = 239/460 (51%), Positives = 314/460 (68%), Gaps = 17/460 (3%)
Query: 192 RIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIA 251
R+ER ++++L+ + +D +++ D DG D + K L+QKILK+TEQIKI
Sbjct: 26 RVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIE 85
Query: 252 QTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQ 311
QT+RD NVAEYLKL N+ADKQQA RIKQVFEKKNQKSA +I QLQKKLE YHRKLRE+EQ
Sbjct: 86 QTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
Query: 312 NGIPRQPKDV----FRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVS 367
NG R KD+ +D+H+ LKD K + + ++S K G S + V +
Sbjct: 146 NGASRSSKDISKDHLKDIHRSLKDAHVK-SRTAPHCMESSKSGMPGVSL---TPPVFVFN 201
Query: 368 KPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSAT 427
K RE A+LIRNKFGSADNI +LK+SLEE + + + +A G + + PKYGS+++CSS T
Sbjct: 202 KSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGT 261
Query: 428 SGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHY 487
SGS +N A GAS TLD Q +L E++EI++TQA+L E E LK +
Sbjct: 262 SGSADSNGNQSFGAGGAS-----TLDSQGK-LAVILEELREIKDTQAQLAEDIEALKVQF 315
Query: 488 QRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARD 547
+R+Y I QTLQEERYR ERLE+QL+DLT+LHQ+E NLKQELAS+EEK+AYQ+YER+RD
Sbjct: 316 KREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRD 375
Query: 548 IQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTV 607
IQEALE+CQTRISK+EL QQ+QQ +Q + A+ LLG+ IN++LA M V+LV VST+
Sbjct: 376 IQEALESCQTRISKLELHQQEQQALQ---TDTVNAKVLLGRCINVILAFMTVILVCVSTI 432
Query: 608 ANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVER 647
A V P+MK+R T F V +A K+WD + +ER
Sbjct: 433 AKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIER 472
>gi|4503177 testis expressed 28 [Homo sapiens]
Length = 410
Score = 135 bits (339), Expect = 2e-31
Identities = 127/432 (29%), Positives = 197/432 (45%), Gaps = 82/432 (18%)
Query: 218 TDSVDGTPDPQR-TKAAIAH-----LQQKILKLTEQIKIAQTARDDNVAEYLKLANSADK 271
+ S DG P +AH ++ +IL L+EQ+++ + +RD N YLKL + AD+
Sbjct: 26 SSSEDGPSGPSSLADGGLAHNLQDSVRHRILYLSEQLRVEKASRDGNTVSYLKLVSKADR 85
Query: 272 QQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKD 331
Q I+Q FEK NQ+++ TI Q++ +L H++L+E+E+ P
Sbjct: 86 HQVPHIQQAFEKVNQRASATIAQIEHRLHQCHQQLQELEEGCRP---------------- 129
Query: 332 VGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKD 391
EG++ + S + + A++S+P E G D NL
Sbjct: 130 ---------EGLLLMAE---SDPANCEPPSEKALLSEPPEP--------GGEDGPVNL-- 167
Query: 392 SLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNT 451
A + + S FQS + C + N + +K
Sbjct: 168 -------PHASRPFILESRFQSL----QQGTCLETEDVAQQQNLLLQKVKAELEEAKRFH 216
Query: 452 LDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQ 511
+ +Q S H ++E T +L E+L+E R Q L EE+ RL+ Q
Sbjct: 217 ISLQES-----YHSLKERSLTDLQL--LLESLQEEKCR------QALMEEQVN-GRLQGQ 262
Query: 512 LNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQV 571
L NEI NLK LA EE++AY SYERA++I E E ++RISK+E+ QQV
Sbjct: 263 L--------NEIYNLKHNLACSEERMAYLSYERAKEIWEITETFKSRISKLEM---LQQV 311
Query: 572 VQLEGLENATAR--NLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVV 629
QLE E+ +R +L K ++ L++ VLLVFVST+ C L+ +R T + L L+
Sbjct: 312 TQLEAAEHLQSRPPQMLFKFLSPRLSLATVLLVFVSTLCACPSSLISSRLCTCTMLMLIG 371
Query: 630 FIAFLWKHWDAL 641
W+ W A+
Sbjct: 372 LGVLAWQRWRAI 383
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2135
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2189
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2247
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2428 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2479
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2480 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2535
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2536 RQQQQMEQ 2543
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1474 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1591
Query: 574 LE 575
LE
Sbjct: 1592 LE 1593
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1645
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1479
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1480 ARAEEAEAQKRQAQ 1493
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 888 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 945 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 999
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 1000 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1042
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1185
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1246 EQLRQEQALLEEIE 1259
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2139
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2193
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2251
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2371
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2372 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2432 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2483
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2484 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2539
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2540 RQQQQMEQ 2547
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1478 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1595
Query: 574 LE 575
LE
Sbjct: 1596 LE 1597
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1411
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1531
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1649
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1425
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1483
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1484 ARAEEAEAQKRQAQ 1497
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2335 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2484
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 892 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 948
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 949 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 1003
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 1004 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1046
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1144 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1189
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1249
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1250 EQLRQEQALLEEIE 1263
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2135
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2189
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2247
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2368 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2428 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2479
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2480 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2535
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2536 RQQQQMEQ 2543
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1474 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1591
Query: 574 LE 575
LE
Sbjct: 1592 LE 1593
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1407
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1527
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1645
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1479
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1480 ARAEEAEAQKRQAQ 1493
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 888 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 945 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 999
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 1000 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1042
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1185
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1245
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1246 EQLRQEQALLEEIE 1259
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2103
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2157
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2215
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2335
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2336 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2396 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2447
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2448 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2503
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2504 RQQQQMEQ 2511
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1442 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1559
Query: 574 LE 575
LE
Sbjct: 1560 LE 1561
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1375
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1495
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1613
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1447
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1448 ARAEEAEAQKRQAQ 1461
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2299 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2417 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2448
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 856 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 912
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 913 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 967
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 968 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1010
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1108 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1153
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1154 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1213
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1214 EQLRQEQALLEEIE 1227
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2272
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2326
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2384
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2504
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2505 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2565 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2616
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2617 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2672
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2673 RQQQQMEQ 2680
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1611 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1728
Query: 574 LE 575
LE
Sbjct: 1729 LE 1730
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1544
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1664
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1782
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1558
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1616
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1617 ARAEEAEAQKRQAQ 1630
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2468 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2586 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2617
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 1025 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 1082 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 1136
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 1137 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1179
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1277 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1322
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1382
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1383 EQLRQEQALLEEIE 1396
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2113
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2167
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2225
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2286 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2345
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2346 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2406 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2457
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2458 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2513
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2514 RQQQQMEQ 2521
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1452 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1569
Query: 574 LE 575
LE
Sbjct: 1570 LE 1571
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1385
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1505
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1565
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1566 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1623
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1399
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1457
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1458 ARAEEAEAQKRQAQ 1471
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2309 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2427 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2458
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 866 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 923 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 977
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 978 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1118 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1163
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1223
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1224 EQLRQEQALLEEIE 1237
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2121
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2175
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2233
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2234 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2294 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2353
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2354 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2414 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2465
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2466 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2521
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2522 RQQQQMEQ 2529
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1460 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1577
Query: 574 LE 575
LE
Sbjct: 1578 LE 1579
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1334 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1393
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1513
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1573
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1574 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1631
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1407
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1465
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1466 ARAEEAEAQKRQAQ 1479
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2317 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2435 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2466
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 874 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 930
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 931 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 985
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 986 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1028
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1126 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1171
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1172 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1231
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1232 EQLRQEQALLEEIE 1245
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 53.9 bits (128), Expect = 5e-07
Identities = 121/608 (19%), Positives = 233/608 (38%), Gaps = 66/608 (10%)
Query: 1 MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR 60
+E + QL + + + + +K +E++ ++ ALE + + ++ + +
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 61 RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS 120
R S +Q Q + + E + A V L + LQQ + RG +
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEK---AHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 121 LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA 180
+RR EA + Q R++ Q V ++ R + S+ A A A A AAA
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ--------ARAQAQAAA 2162
Query: 181 ACLPGE-EGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQ 239
L E E A R + E ++L Q +A A H + T R KA +
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQT---LRQKAQVEQELT 2216
Query: 240 KILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKL 299
+ E+ + D+ + A A +Q++ +++F + Q + + +L+ ++
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ--MEELSKLKARI 2274
Query: 300 EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEG----------------- 342
E +R L +++ R ++ M Q ++ E
Sbjct: 2275 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
Query: 343 VVDSVKGGFSSFSQATHSAAGA-VVSKPREIASLIRNKFGS---------ADNIPNLKDS 392
+K + +AT A A ++ + +E+A + A+ + +
Sbjct: 2335 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2394
Query: 393 LE---EGQVDDAGKA--LGVISNFQSSPKYGSEEDCS--SATSGSVGANSTTGGIAVGAS 445
LE + Q++ + +A L + S + +EED + +G +A
Sbjct: 2395 LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 446 SSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRC 505
+ TL++Q D H+ + +RE A LE E L++ + ++Q EE
Sbjct: 2455 VTLVQTLEIQRQQSD---HDAERLREAIAELEREKEKLQQE-----AKLLQLKSEEMQTV 2506
Query: 506 ERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQ 565
+ +EQL T+ Q L+ K L E I + + + Q+ E + + + E Q
Sbjct: 2507 Q--QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD--EVAKAQQLREEQQ 2562
Query: 566 QQQQQVVQ 573
+QQQQ+ Q
Sbjct: 2563 RQQQQMEQ 2570
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 16/122 (13%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
E++ +AR EE+ E K Q + + + +Q+E R + E +L + +
Sbjct: 1501 ELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
Query: 528 QELASMEE----------KIAYQSYERARDIQEALEACQTRISKMELQQQQ----QQVVQ 573
+ L ++EE ++ ERAR +Q ALE Q R ++ ELQ ++ ++ Q
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRASFAEKTAQ 1618
Query: 574 LE 575
LE
Sbjct: 1619 LE 1620
Score = 33.1 bits (74), Expect = 0.83
Identities = 71/358 (19%), Positives = 138/358 (38%), Gaps = 38/358 (10%)
Query: 7 EQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVS 66
E+L E + + AE E +++L++ A + L+ Q + R +
Sbjct: 1375 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA 1434
Query: 67 PHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALN----RVLQQIRV------PPKMK 116
D QQ + + E+ Q++ AEI A R+ ++IRV + +
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 117 RGTS---LHSRRGKPEAPKGSPQINRKSGQEMTAVMQ--SGRPRSSSTTDAPTSSAMMEI 171
RG + L + R + E + + ++ + + +Q S R R + A A E
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1554
Query: 172 ACAAAAAAAAC----LPGEE-------GTAERIERLEVS--SLAQTSSAVASSTDGSIHT 218
A A A L EE ER +++V+ + +++ A S S
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1614
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
+ Q A+A L+++ + +Q A+ AR++ E + A+ +A R++
Sbjct: 1615 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN--EALRLR 1672
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLRE--------VEQNGIPRQPKDVFRDMHQG 328
E+ Q+ + + +K+ E R+ R V Q + Q + R + +G
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
Score = 32.3 bits (72), Expect = 1.4
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 28/134 (20%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER-----------LEEQ 511
L E++ E Q +L E+ K +R+ + Q +QEE R E ++E+
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1448
Query: 512 LNDLTELHQNEI--------------LNLKQELASMEEKIAYQSYERARDIQEA-LEACQ 556
L L + + EI L +++E+ + ++ ++ ER R E L+A +
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALR 1506
Query: 557 TRISKMELQQQQQQ 570
R + E Q++Q Q
Sbjct: 1507 ARAEEAEAQKRQAQ 1520
Score = 32.0 bits (71), Expect = 1.8
Identities = 33/152 (21%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 462 LLHEIQEIRETQAR-LEESFETLKEHYQRDYSLIMQTLQEERYR---------------- 504
LL + +E+ + QAR L+E E + + + +TL+ ER R
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 505 ------------CERLEEQLNDLTE-LHQNEILNLKQELASMEEKIAYQSYERARDIQEA 551
+R +Q ++ E LH+ E+ QE ++ + + Q + D +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 552 LEACQTRISKMELQQQQQQVVQLEGLENATAR 583
EA + E QQ+ +++QL+ E T +
Sbjct: 2476 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2507
Score = 30.8 bits (68), Expect = 4.1
Identities = 39/163 (23%), Positives = 65/163 (39%), Gaps = 39/163 (23%)
Query: 452 LDMQSS-GFDALLHEIQEIRETQARLEESFETLKEHYQRD--------YSLIMQTLQ--- 499
+DM+S + +L ++Q IR +F TLK QR Y ++ Q
Sbjct: 915 VDMKSLLAWQSLRRDVQLIRSWSLA---TFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971
Query: 500 ----EERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC 555
E+R ER + + +Q + +L+Q + EE + +DI+ LEAC
Sbjct: 972 GFGPEDRLMAER---EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCISELKDIRLQLEAC 1026
Query: 556 QTRI---------------SKMELQQQQQQVVQLEGLENATAR 583
+TR + +QQ+ ++EGL AR
Sbjct: 1027 ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1069
Score = 29.6 bits (65), Expect = 9.1
Identities = 35/134 (26%), Positives = 60/134 (44%), Gaps = 22/134 (16%)
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQL 512
+ Q FDAL E++ +E RL++ H +RD ++ ER+R ER+ + L
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQ------RHGERD-------VEVERWR-ERVAQLL 1212
Query: 513 N------DLTELHQNEILNLKQELASMEEKIAYQS--YERARDIQEALEACQTRISKMEL 564
T++ Q E+ L ++L E + AR QE ++A S+
Sbjct: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1272
Query: 565 QQQQQQVVQLEGLE 578
+Q +Q+ LE +E
Sbjct: 1273 EQLRQEQALLEEIE 1286
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 47.4 bits (111), Expect = 4e-05
Identities = 35/134 (26%), Positives = 61/134 (45%), Gaps = 19/134 (14%)
Query: 461 ALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER------------- 507
A E+++ T + EE+ LK I +T +EER ++
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470
Query: 508 ---LEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 564
EEQ+ L +LH+ E+ +QEL +K+ + E ++ ALE Q+ K+
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELT---KKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 565 QQQQQQVVQLEGLE 578
+++QQ+ + LE LE
Sbjct: 528 EKEQQESLALEELE 541
Score = 47.4 bits (111), Expect = 4e-05
Identities = 89/436 (20%), Positives = 168/436 (38%), Gaps = 70/436 (16%)
Query: 189 TAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQI 248
T E+ E SL Q S V D + + + Q K H ++ K E
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEV-----VDVMKKSSEEQIAKLQKLHEKELARKEQELT 497
Query: 249 KIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKS-AQTILQLQKKLEHYHRKLR 307
K QT R+ E +K+A +K Q+ +K EK+ Q+S A L+LQKK
Sbjct: 498 KKLQT-REREFQEQMKVA--LEKSQSEYLKISQEKEQQESLALEELELQKK--------- 545
Query: 308 EVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVS 367
I + ++ RD+ Q + ++ + S++ +
Sbjct: 546 -----AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 368 KPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSAT 427
+EI ++ +++ + +D+L + L V+ + E C
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWT-------EKLQVLKQQYQTEMEKLREKCEQEK 653
Query: 428 SGSVGANSTTGGIAVGASSSKT-NTLDMQSSGFDALLHEIQEIRETQARLEESFETLKE- 485
+ + + KT LD++ + ++L E+ E+ + + +LEE LK+
Sbjct: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ 713
Query: 486 -----------------HYQRDYSLIMQTLQEERYRCER-LEEQLNDLTEL--------- 518
H+Q+ I++ + R E+ L++Q+N L L
Sbjct: 714 TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773
Query: 519 -HQNEILNLKQELASMEEKIAYQSYERARDIQEALEAC---QTRISKMELQQQQQQVVQL 574
HQ + NL+ ++ E ++ Q D+ ++ ++ QT+ + +L Q QQ+++ L
Sbjct: 774 EHQAHVENLEADIKRSEGEL--QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Query: 575 EGLENATARNLLGKLI 590
E T R LL K +
Sbjct: 832 E-----TERILLTKQV 842
Score = 42.4 bits (98), Expect = 0.001
Identities = 75/359 (20%), Positives = 147/359 (40%), Gaps = 69/359 (19%)
Query: 228 QRTKA---AIAHLQQKILKL-TEQIKIA-QTARDDNVAEYLKLANSADKQQAARIKQVFE 282
++TKA +A LQQK+L L TE+I + Q A + + + A K Q + Q E
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Query: 283 KKNQKSAQTILQL----QKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLK---DVGAK 335
K+N + Q + L + KLE +++ + +Q I + +++ M +G K ++ +
Sbjct: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ--ILVEKENMILQMREGQKKEIEILTQ 929
Query: 336 VTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEE 395
E + + + + + V K +E+ ++ K D LK LE
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL--LDQEAKLKKELEN 987
Query: 396 GQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQ 455
++ + K E+ ++ ANS GI+ S +TN
Sbjct: 988 TALELSQK----------------EKQFNAKMLEMAQANSA--GISDAVSRLETNQ---- 1025
Query: 456 SSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDL 515
+E E+L E ++R+ + ++ ++ +L +Q +L
Sbjct: 1026 ---------------------KEQIESLTEVHRRELNDVISIWEK------KLNQQAEEL 1058
Query: 516 TELHQNEILNLKQELASMEEKIAYQSYERARDIQEAL----EACQTRISKMELQQQQQQ 570
E+H+ ++ +QE+A +++KI E+ +E E + + ELQ+Q +Q
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ 1117
Score = 41.6 bits (96), Expect = 0.002
Identities = 102/540 (18%), Positives = 209/540 (38%), Gaps = 61/540 (11%)
Query: 62 RSSVSPHDVQQIQA--DPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGT 119
R S++ D+ A DP +MD E+++ D + +++Q++R +M+R
Sbjct: 99 RESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKE-----QLIQRLR---RMER-- 148
Query: 120 SLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAA 179
SL S RGK + Q+ ++ +++ ++ + +S M+
Sbjct: 149 SLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQ- 207
Query: 180 AACLPGEEGTAERIERLEVSSLAQTSSAVASST--DGSIHTDSVDGTPDPQRTKAAIAHL 237
EE A E+ + S+ QT ++ +G ++ D + P PQ A
Sbjct: 208 ------EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK--PLPQLEPQAEVFT 259
Query: 238 QQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEK-KNQKSAQTILQLQ 296
+++ + D + L+ K+Q +K+ E ++ K T+L +
Sbjct: 260 KEE----NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315
Query: 297 KKL--EHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSS- 353
K+ E +L+E+E+ +D+H K ++ +++ ++
Sbjct: 316 KEALQEQLDERLQELEK----------IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV 365
Query: 354 FSQATHSAAGAVVSKPREIASL---IRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISN 410
++ + K EIA L I+ + + K+ E ++ KAL
Sbjct: 366 IAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK 425
Query: 411 FQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIR 470
+ + + E + + + S K +D+ + + ++Q++
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485
Query: 471 ETQ-ARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQE 529
E + AR E+ + +R++ M+ E+ E L E Q E L L +E
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVALEKSQ-----SEYLKISQEKEQQESLAL-EE 539
Query: 530 LASMEEKIAYQSYERARDIQEALEACQTRISKME------LQQQQQQ----VVQLEGLEN 579
L ++ I +S + RD+Q+ E +TRI ++E LQ+ + Q V LE +N
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Score = 37.0 bits (84), Expect = 0.057
Identities = 27/125 (21%), Positives = 61/125 (48%), Gaps = 9/125 (7%)
Query: 450 NTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLE 509
N L+ + +G + E Q++ + RL++ L++ +Q++ ++ + +ER E+++
Sbjct: 1926 NDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE--EKIK 1980
Query: 510 EQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQ 569
++ DL H + LKQ + ++A + E I+E + Q + L+ Q+
Sbjct: 1981 QEQEDLELKHNS---TLKQLMREFNTQLAQKEQELEMTIKETINKAQ-EVEAELLESHQE 2036
Query: 570 QVVQL 574
+ QL
Sbjct: 2037 ETNQL 2041
Score = 33.1 bits (74), Expect = 0.83
Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 484 KEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTE--LHQNEILNLK-QELASMEEKI-AY 539
K++ + + + +TLQE+ C+ LE+++ +L + Q E+ ++ +EL S EK+ A
Sbjct: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
Query: 540 QSYERARDIQEALEACQTRISKMELQQ 566
Q + E LE SK L Q
Sbjct: 1888 QQMDGRNKPTELLEENTEEKSKSHLVQ 1914
Score = 32.3 bits (72), Expect = 1.4
Identities = 22/119 (18%), Positives = 52/119 (43%), Gaps = 1/119 (0%)
Query: 452 LDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQ 511
LD Q+ FD L E+++ + + E + ET + + + ++ E L E
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV 1547
Query: 512 LNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQ 570
L + + E L Q+L +E + + R ++ +E + + ++ M+ + + ++
Sbjct: 1548 LKNYNQQKDIEHKELVQKLQHFQE-LGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605
Score = 30.4 bits (67), Expect = 5.4
Identities = 65/386 (16%), Positives = 150/386 (38%), Gaps = 46/386 (11%)
Query: 235 AHLQQKILKLTEQIKIAQTARDD---NVAEYLKLANSAD------KQQAARIKQVFEKK- 284
AH+++ K E++ + QT + ++E LK + + K Q ++KQ E K
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM 725
Query: 285 -------NQKSAQTILQLQKKLEHYHRKLRE-VEQNGIPRQPKDVFRDMHQG-LKDVGAK 335
Q+ I + + ++ + L++ + Q + + +D HQ ++++ A
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 336 VTGFSEGVVDSVKGG---FSSFSQATHSAAGA----VVSKPREIASLIRNKFGSADNIPN 388
+ SEG + F S+ ATH A + +++ L + +
Sbjct: 786 IKR-SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
Query: 389 LKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSK 448
++ ++ + + V Q K SE + + V + G +
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG---NKEQEQ 901
Query: 449 TNTLDMQSSGF-----DALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERY 503
T + ++ + EI+ + + + E+S L E Y+ + + +
Sbjct: 902 TKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF-------KNQEK 954
Query: 504 RCERLEEQLNDLTELHQNEILN----LKQELASMEEKIAYQSYERARDIQEALEACQTRI 559
+ E+++++ ++ E + ++L+ LK+EL + +++ + + + E +A I
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 560 SKMELQQQQQQVVQLEGLENATARNL 585
S + + Q Q+E L R L
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRREL 1040
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 46.2 bits (108), Expect = 9e-05
Identities = 81/438 (18%), Positives = 171/438 (39%), Gaps = 53/438 (12%)
Query: 194 ERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQT 253
E +V+SL +T S + + D ++ K L++ KL +K+AQ
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVE--------DLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 254 ARDDNVAEYLKLANSADKQQAARIKQVFE----KKNQKSAQTI-LQLQKKLEHYHRKLRE 308
+ L L N + K+ FE + + QT+ LQ QKK++ ++ E
Sbjct: 1066 S-------ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Query: 309 VEQN---------GIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATH 359
+E+ +Q D R++ + L + + G + ++ K + F +
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEE-LSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 360 SAAGAVVSKPREIASLIRNKFGSA-------DNIPNLKDSLEEG------QVDDAGKALG 406
A + +A+L + S DN+ +K LE+ ++DD ++
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Query: 407 VISNFQSSPK---YGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNT--LDMQSSGFDA 461
+S +++ + E+ S A + + + S +T L Q ++
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES 1297
Query: 462 LLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELH-- 519
++ ++ ++ + E + E + + + LQ R+ C+ L EQ + E
Sbjct: 1298 IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1357
Query: 520 -QNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLE 578
Q + E+A K + +R +++EA + R+ E +Q + + LE
Sbjct: 1358 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE-EQVEAVNAKCASLE 1416
Query: 579 NATARNLLGKLINILLAV 596
T + L G++ ++++ V
Sbjct: 1417 K-TKQRLQGEVEDLMVDV 1433
Score = 38.9 bits (89), Expect = 0.015
Identities = 40/138 (28%), Positives = 63/138 (45%), Gaps = 26/138 (18%)
Query: 440 IAVGASSSKTNTLDMQSSGFDALLHEIQ-EIRETQARLEESFETLKEHYQRDYSLIMQTL 498
+ V ++S LD + FD +L E + + E+QA LE S LKE ++L
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS---LKES---------RSL 1478
Query: 499 QEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIA-----YQSYERAR------- 546
E ++ + E+ D E + E NL+QE+A + E+IA E++R
Sbjct: 1479 STELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538
Query: 547 -DIQEALEACQTRISKME 563
DIQ ALE + + E
Sbjct: 1539 ADIQLALEEAEAALEHEE 1556
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 46.2 bits (108), Expect = 9e-05
Identities = 38/144 (26%), Positives = 73/144 (50%), Gaps = 14/144 (9%)
Query: 453 DMQSSGFD----ALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERL 508
DM +GF +L E+Q+I +++ E S +K+ RD ++ +EE L
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQL-RDLEAKVKDQEEE------L 1558
Query: 509 EEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQ 568
+EQ + L Q + L L+ E+ M + + + R +++EA ++CQ ++ +ME+Q ++
Sbjct: 1559 DEQAGTIQMLEQAK-LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 569 QQVVQLEGLENATARNLLGKLINI 592
+ + + L R L GKL +
Sbjct: 1618 EYEDKQKVLRE--KRELEGKLATL 1639
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 28/300 (9%)
Query: 276 RIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAK 335
R++Q FE K + Q QL+++L E ++ +Q K + + L+D
Sbjct: 1388 RLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQR--ALQQLKKKCQRLTAELQDTKLH 1445
Query: 336 VTG--FSEGVVDSVKGGFSS-FSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDS 392
+ G ++ + F S SQA A + + + L R K +LK
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK----LQREKDMLLAEAFSLKQQ 1501
Query: 393 LEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTL 452
LEE +D AG V+S S+E A+ V V + L
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV---KDQEEEL 1558
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER----- 507
D Q+ IQ + + + RLE E +++ + ++ + ++E R C++
Sbjct: 1559 DEQAG-------TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 508 ---LEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 564
LEE+ D ++ E L+ +LA++ +++ + +E + +++ L+ + ++ +L
Sbjct: 1612 EVQLEEEYEDKQKV-LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQL 1670
Score = 32.0 bits (71), Expect = 1.8
Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 34/143 (23%)
Query: 466 IQEIRETQARLEESFETLKE--------------HYQRDYSLIMQTLQEERYRCERLEEQ 511
++E+ T+ RL++ FE E Q D + LQ+ + +C+RL +
Sbjct: 1379 VREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAE 1438
Query: 512 LNDLTELH------QNEILNLKQ-----ELA-----SMEEKIAYQSYERARD--IQEALE 553
L D T+LH +N L KQ EL+ + EK+ + +R +D + EA
Sbjct: 1439 LQD-TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 554 ACQTRISK-MELQQQQQQVVQLE 575
Q K M++ Q+VV LE
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLE 1520
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 46.2 bits (108), Expect = 9e-05
Identities = 38/144 (26%), Positives = 73/144 (50%), Gaps = 14/144 (9%)
Query: 453 DMQSSGFD----ALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERL 508
DM +GF +L E+Q+I +++ E S +K+ RD ++ +EE L
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQL-RDLEAKVKDQEEE------L 1558
Query: 509 EEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQ 568
+EQ + L Q + L L+ E+ M + + + R +++EA ++CQ ++ +ME+Q ++
Sbjct: 1559 DEQAGTIQMLEQAK-LRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 569 QQVVQLEGLENATARNLLGKLINI 592
+ + + L R L GKL +
Sbjct: 1618 EYEDKQKVLRE--KRELEGKLATL 1639
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 28/300 (9%)
Query: 276 RIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAK 335
R++Q FE K + Q QL+++L E ++ +Q K + + L+D
Sbjct: 1388 RLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQR--ALQQLKKKCQRLTAELQDTKLH 1445
Query: 336 VTG--FSEGVVDSVKGGFSS-FSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDS 392
+ G ++ + F S SQA A + + + L R K +LK
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREK----LQREKDMLLAEAFSLKQQ 1501
Query: 393 LEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTL 452
LEE +D AG V+S S+E A+ V V + L
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV---KDQEEEL 1558
Query: 453 DMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCER----- 507
D Q+ IQ + + + RLE E +++ + ++ + ++E R C++
Sbjct: 1559 DEQAG-------TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQM 1611
Query: 508 ---LEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 564
LEE+ D ++ E L+ +LA++ +++ + +E + +++ L+ + ++ +L
Sbjct: 1612 EVQLEEEYEDKQKV-LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQL 1670
Score = 32.0 bits (71), Expect = 1.8
Identities = 39/143 (27%), Positives = 63/143 (44%), Gaps = 34/143 (23%)
Query: 466 IQEIRETQARLEESFETLKE--------------HYQRDYSLIMQTLQEERYRCERLEEQ 511
++E+ T+ RL++ FE E Q D + LQ+ + +C+RL +
Sbjct: 1379 VREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAE 1438
Query: 512 LNDLTELH------QNEILNLKQ-----ELA-----SMEEKIAYQSYERARD--IQEALE 553
L D T+LH +N L KQ EL+ + EK+ + +R +D + EA
Sbjct: 1439 LQD-TKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 554 ACQTRISK-MELQQQQQQVVQLE 575
Q K M++ Q+VV LE
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLE 1520
>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
sapiens]
Length = 1002
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/276 (21%), Positives = 106/276 (38%), Gaps = 33/276 (11%)
Query: 296 QKKLEHYHRKLREVEQNGIPRQPKDVFRDMH-QGLKDVGAKVTGFSEGVVDSVKGGFSSF 354
Q KL +KLRE +Q P P + + + +G D+ K ++
Sbjct: 19 QSKLAAAKKKLREYQQRNSPGVPTGAKKKKKIKNGSNPETTTSGGCHSPEDTPKDNAATL 78
Query: 355 SQATHSAA-GAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQS 413
+ + G V S + S+ ++ ADN+PNL D + F S
Sbjct: 79 QPSDDTVLPGGVPSPGASLTSMAASQNHDADNVPNLMDETK---------------TFSS 123
Query: 414 SPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQ 473
+ S S +G V ++T ASS+ L+ S + L + T
Sbjct: 124 TE---SLRQLSQQLNGLVCESATCVNGEGPASSANLKDLE---SRYQQLAVALDSSYVTN 177
Query: 474 ARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASM 533
+L + E LK+ Q I L+EE+ C + + L + ++H I L E A +
Sbjct: 178 KQLNITIEKLKQQNQE----ITDQLEEEKKECHQKQGALREQLQVHIQTIGILVSEKAEL 233
Query: 534 EEKIAY------QSYERARDIQEALEACQTRISKME 563
+ +A+ Q + D+ L+ + R+ ++E
Sbjct: 234 QTALAHTQHAARQKEGESEDLASRLQYSRRRVGELE 269
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 15/137 (10%)
Query: 449 TNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTL-QEERYRCER 507
T L SS D +L Q ++E Q+RLE+ + H + + + L Q E+ R
Sbjct: 282 TQLLQQSSSQKDEIL---QTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSR 338
Query: 508 LEEQLND-LTELHQNEIL-NLKQELASMEEKIAYQSYE----RARDIQEAL-----EACQ 556
+++ L D + +EIL +L+ E ME+ ++ E R RD+ A+ E+C+
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCK 398
Query: 557 TRISKMELQQQQQQVVQ 573
R+ +M + Q+Q +VQ
Sbjct: 399 NRLIQMAYESQRQNLVQ 415
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 15/137 (10%)
Query: 449 TNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTL-QEERYRCER 507
T L SS D +L Q ++E Q+RLE+ + H + + + L Q E+ R
Sbjct: 282 TQLLQQSSSQKDEIL---QTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSR 338
Query: 508 LEEQLND-LTELHQNEIL-NLKQELASMEEKIAYQSYE----RARDIQEAL-----EACQ 556
+++ L D + +EIL +L+ E ME+ ++ E R RD+ A+ E+C+
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCK 398
Query: 557 TRISKMELQQQQQQVVQ 573
R+ +M + Q+Q +VQ
Sbjct: 399 NRLIQMAYESQRQNLVQ 415
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 15/137 (10%)
Query: 449 TNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTL-QEERYRCER 507
T L SS D +L Q ++E Q+RLE+ + H + + + L Q E+ R
Sbjct: 282 TQLLQQSSSQKDEIL---QTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSR 338
Query: 508 LEEQLND-LTELHQNEIL-NLKQELASMEEKIAYQSYE----RARDIQEAL-----EACQ 556
+++ L D + +EIL +L+ E ME+ ++ E R RD+ A+ E+C+
Sbjct: 339 IQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCK 398
Query: 557 TRISKMELQQQQQQVVQ 573
R+ +M + Q+Q +VQ
Sbjct: 399 NRLIQMAYESQRQNLVQ 415
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 44.7 bits (104), Expect = 3e-04
Identities = 79/413 (19%), Positives = 164/413 (39%), Gaps = 60/413 (14%)
Query: 191 ERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKI 250
E + + S L SS +S G+ H S G + + L Q + +L
Sbjct: 200 EELSHINQSLLQSQSSGDSSDDSGAQHPSS--GEKLKYNQQGEVQQLHQNLHRLQILCNS 257
Query: 251 AQTA----RDDNVAEYLKLANSADKQQAARIKQVFEKKNQK---SAQTILQLQKKLEHYH 303
A+ R N+ LK NS +++ +IK + QK S + L + +H
Sbjct: 258 AENELRYERGQNLD--LKQHNSLLQEENIKIKIELKHAQQKLLDSTKMCSSLTAEYKHCQ 315
Query: 304 RKLREVEQNGIPR-QPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAA 362
+K++E+E + Q ++ + L +KV E ++D + + H
Sbjct: 316 QKIKELELEVLKHTQSIKSQNNLQEKLVQEKSKVADAEEKILDLQRK-----LEHAHKVC 370
Query: 363 --GAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQ---------VDDAGKALGVISNF 411
+S+ +++ I+ + N +K +E Q VD+ + + + +
Sbjct: 371 LTDTCISEKQQLEEKIKE---ATQNEAKVKQQYQEEQQKRKLLYQNVDELHRQVRTLQDK 427
Query: 412 QSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRE 471
++ E CS S + + L+ + +D + QE+ E
Sbjct: 428 ENL----LEMTCSQQQS------------RIQQQEALLKQLENEKRKYDEHVKSNQELSE 471
Query: 472 TQARLEESFETLKEHYQRDYSLI-------MQTLQEERYRCERLEEQLNDLTELHQNEIL 524
++L++ E L+E Y R L+ + +++ + ++++ +L + EL I
Sbjct: 472 KLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYRLTNEVELRDKRIN 531
Query: 525 NLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGL 577
+ E+ ++ KI E+ + IQ+ + A Q +E ++ Q+QV++ E L
Sbjct: 532 QFEDEIGILQHKI-----EKEKAIQDQITA-QNDTLLLEKRKLQEQVIEQEQL 578
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 44.7 bits (104), Expect = 3e-04
Identities = 72/377 (19%), Positives = 145/377 (38%), Gaps = 39/377 (10%)
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
D ++G+ + + K L++ KL +K+AQ + D + +L N K++ +
Sbjct: 1036 DDLEGSLEQE--KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL-NEKLKKKEFEMS 1092
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQN---------GIPRQPKDVFRDMHQGL 329
+ K + A I QLQKK++ ++ E+E+ +Q D+ R++ + +
Sbjct: 1093 NLQGKIEDEQALAI-QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-I 1150
Query: 330 KDVGAKVTGFSEGVVDSVKGGFSSF---------SQATHSAAGAVVSKPREIASLIRNKF 380
+ + G + ++ K + F S H A A + K A +
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH--ADSVAELG 1208
Query: 381 GSADNIPNLKDSLEEGQVDDAGKALGVISNFQ--SSPKYGSEEDCSSATS--GSVGANST 436
D++ +K LE+ + + + + SN + S K E+ C + +
Sbjct: 1209 EQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE 1268
Query: 437 TGGIAVGASSSKTNTLDMQSSGFDALLHE----IQEIRETQARLEESFETLKEHYQRD-- 490
+ S++ L +S F L E + ++ + + E LK + +
Sbjct: 1269 EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETK 1328
Query: 491 -YSLIMQTLQEERYRCERLEEQLNDLTELH---QNEILNLKQELASMEEKIAYQSYERAR 546
S + LQ R+ C+ L EQ + E Q + E+A K + +R
Sbjct: 1329 AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 547 DIQEALEACQTRISKME 563
+++EA + R+ E
Sbjct: 1389 ELEEAKKKLAQRLQDAE 1405
Score = 38.1 bits (87), Expect = 0.026
Identities = 46/163 (28%), Positives = 76/163 (46%), Gaps = 27/163 (16%)
Query: 440 IAVGASSSKTNTLDMQSSGFDALLHEI-QEIRETQARLEESFETLKEHYQRDYSLIMQTL 498
I V S++ LD + FD +L E Q+ ETQA LE S Q++ ++L
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS--------QKE----SRSL 1481
Query: 499 QEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTR 558
E ++ + E+ D E + E NL+QE++ + E+IA E + I E LE + +
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIA----EGGKHIHE-LEKVKKQ 1536
Query: 559 I--SKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAV 599
+ K ELQ ++ A+ + GK++ I L + V
Sbjct: 1537 LDHEKSELQTSLEEA-------EASLEHEEGKILRIQLELNQV 1572
Score = 32.3 bits (72), Expect = 1.4
Identities = 66/313 (21%), Positives = 122/313 (38%), Gaps = 43/313 (13%)
Query: 20 QDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEP 79
Q AEA + + Q + K T L++ LK RR+++ +V++++A E
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLE- 1697
Query: 80 EMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINR 139
E AE + + RV + TSL + + K E I++
Sbjct: 1698 --RTERGRKMAEQELLDASE----------RVQLLHTQNTSLINTKKKLET-----DISQ 1740
Query: 140 KSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVS 199
G EM ++Q R A T +AMM A L E+ T+ +ER++
Sbjct: 1741 IQG-EMEDIVQEARNAEEKAKKAITDAAMM----------AEELKKEQDTSAHLERMK-K 1788
Query: 200 SLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNV 259
++ QT + D + G Q+ +A + L+ ++ ++ + NV
Sbjct: 1789 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEV----------ESEQKHNV 1838
Query: 260 AEYLKLANSADKQQAARIKQVFEKKNQKSAQTIL-QLQKKLEHYHRKLREVEQNGIPRQP 318
L + + + ++KN Q ++ +LQ K++ Y R+ E E+
Sbjct: 1839 EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA 1898
Query: 319 KDVFRDMHQGLKD 331
K FR + L++
Sbjct: 1899 K--FRKLQHELEE 1909
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 44.3 bits (103), Expect = 4e-04
Identities = 79/403 (19%), Positives = 160/403 (39%), Gaps = 65/403 (16%)
Query: 212 TDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIA-----QTARDDNVA------ 260
T + DS D + +A IA L+ ++ K E+++ A + A N+A
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 261 ---EYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLE---------HYHRKLRE 308
+ +L + ++A+R K EK+ + + + L+ +LE R RE
Sbjct: 1109 LESQISELQEDLESERASRNKA--EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 309 VEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDS------VKGGFSSFSQATHSAA 362
E N + + ++ + ++++ K + E + + VK Q +
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 363 GAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEED 422
G + + E+ L++ K S ++ L+E QV F + +E
Sbjct: 1227 GELAN---EVKVLLQGKGDSEHKRKKVEAQLQELQV-----------KFNEGERVRTEL- 1271
Query: 423 CSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFET 482
T V ++ TG + S SK++ L S ++ L + QE+ + + R + S T
Sbjct: 1272 ADKVTKLQVELDNVTG--LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST 1329
Query: 483 LKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKI--AYQ 540
+ + + + + L+EE LE+Q I L ++A M++K+ +
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQ-----------IATLHAQVADMKKKMEDSVG 1378
Query: 541 SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATAR 583
E A +++ L+ +S Q+ +++V + LE R
Sbjct: 1379 CLETAEEVKRKLQKDLEGLS----QRHEEKVAAYDKLEKTKTR 1417
Score = 32.7 bits (73), Expect = 1.1
Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 12/136 (8%)
Query: 452 LDMQSSGFDALLHEIQEIRETQARLEESFET----LKEHYQRDYSLIMQTLQEERYRCER 507
L+ + + F L E +E ++ A+L+ E L+E +R+ Q L++ R + E
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ-RQELEKTRRKLEG 1055
Query: 508 LEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQ 567
L+D Q +I LK +LA EE++ +A + EA Q ++ ++++
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEEL------QAALARVEEEAAQKNMALKKIREL 1109
Query: 568 QQQVVQL-EGLENATA 582
+ Q+ +L E LE+ A
Sbjct: 1110 ESQISELQEDLESERA 1125
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/369 (19%), Positives = 150/369 (40%), Gaps = 52/369 (14%)
Query: 234 IAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARI--KQVFEKKNQKSAQT 291
+ LQ + +LTE+ A E+L+ +K+ +A + K+ E+KN+
Sbjct: 334 LQQLQDALNELTEEHSKA-------TQEWLEKQAQLEKELSAALQDKKCLEEKNEI---- 382
Query: 292 ILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQ--GLKDVGAKVTGFS---EGVVDS 346
LQ KL L +++ N P++ +V D+ Q LK A + + + V+
Sbjct: 383 ---LQGKLSQLEEHLSQLQDNP-PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
Query: 347 VKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALG 406
++ + G + ++++SLI + S N+ K+ LE+ +
Sbjct: 439 LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
Query: 407 VISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSK---TNTLDMQSSGFDALL 463
+++ S + ++ + + G+ A + TL Q L
Sbjct: 499 QVASLTS--------ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 550
Query: 464 HEIQEIRETQARLEESFETLKEHYQ---RDYSLIMQTLQEER-----------YRCERLE 509
H+++++ + + E+ + + E + +D++ + T EER + E LE
Sbjct: 551 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
Query: 510 EQLNDLTELHQNEILNLKQELASMEEKIAYQSYERA---RDIQEALEACQTRISKMELQQ 566
++ E+ Q ++ + S + + E+A R ++E L+AC ++ E +
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEE-LQAC-VETARQEQHE 668
Query: 567 QQQQVVQLE 575
Q QV +LE
Sbjct: 669 AQAQVAELE 677
Score = 41.2 bits (95), Expect = 0.003
Identities = 76/343 (22%), Positives = 134/343 (39%), Gaps = 58/343 (16%)
Query: 228 QRTKAA-IAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQ 286
++ KAA + LQQ++ E AQT+ E +L+ ++ QA ++ +++++
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC-VETARQEQHE 668
Query: 287 KSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDS 346
AQ + +L+ +L +K E E+ Q KD ++ Q LK+ S
Sbjct: 669 AQAQ-VAELELQLRSEQQKATEKERVA---QEKDQLQEQLQALKE--------------S 710
Query: 347 VKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAG--KA 404
+K S + AA A+ + R I+ L + + LEE + G
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 405 LGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLH 464
L + + + + A + A S + ++ + D Q
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ--------- 821
Query: 465 EIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEE--------QLNDLT 516
QE + A +E TLKE ++ Q LQE + + +E Q N+L
Sbjct: 822 --QEEAQYGAMFQEQLMTLKEECEK----ARQELQEAKEKVAGIESHSELQISRQQNELA 875
Query: 517 ELHQNEILNLKQ-------------ELASMEEKIAYQSYERAR 546
ELH N L+Q +L++++EK+A S E AR
Sbjct: 876 ELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
Score = 39.7 bits (91), Expect = 0.009
Identities = 86/389 (22%), Positives = 147/389 (37%), Gaps = 53/389 (13%)
Query: 198 VSSLAQTSSAV--ASSTDGSIHTDSVDG-TPDPQRTKAAIAHLQQKILKLTEQIK----- 249
+S+L+Q + AS G+ T V T + A I Q++ L +Q K
Sbjct: 475 ISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQ 534
Query: 250 IAQTARDDNVAEY-----LKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHR 304
+AQT + A ++ +S+ KQ+ ++K+V EK+ QL E
Sbjct: 535 LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREA 594
Query: 305 KLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGA 364
LRE + + + K+ AK ++ ++ ++A SA +
Sbjct: 595 SLRERDA---------ALKQLEALEKEKAAK--------LEILQQQLQVANEARDSAQTS 637
Query: 365 VVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSS---PKYGSEE 421
V RE A L R + + E Q A L + S Q + + E+
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK 697
Query: 422 DCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFE 481
D + +K + + + DAL +E + + L+
Sbjct: 698 D---------QLQEQLQALKESLKVTKGSLEEEKRRAADAL----EEQQRCISELKAETR 744
Query: 482 TLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQS 541
+L E ++R+ + L+EER + LE +L L E HQ E L++ELA E +A Q
Sbjct: 745 SLVEQHKRE----RKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELA---EAMAAQH 797
Query: 542 YERARDIQEALEACQTRISKMELQQQQQQ 570
+ Q E R + QQ++ Q
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQ 826
Score = 34.7 bits (78), Expect = 0.28
Identities = 27/119 (22%), Positives = 53/119 (44%), Gaps = 11/119 (9%)
Query: 468 EIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLK 527
++ E QA+L + E EHY+ ++ + + L+EQL L +L +
Sbjct: 1592 QLNELQAQLSQK-EQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE-----N 1645
Query: 528 QELASMEEKIAYQSYERARDIQEALEAC-----QTRISKMELQQQQQQVVQLEGLENAT 581
+EL + E++ ++ + +EA + C Q R + ++ QQ+ L + AT
Sbjct: 1646 KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT 1704
Score = 34.3 bits (77), Expect = 0.37
Identities = 27/116 (23%), Positives = 59/116 (50%), Gaps = 7/116 (6%)
Query: 463 LHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNE 522
L + Q+++ +++++ L E D S L+E ++L++ LN+LTE H
Sbjct: 296 LKQCQDLKTEKSQMDRKINQLSEE-NGDLSF---KLREFASHLQQLQDALNELTEEHSKA 351
Query: 523 ILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKME--LQQQQQQVVQLEG 576
++ A +E++++ + + + ++E E Q ++S++E L Q Q Q +G
Sbjct: 352 TQEWLEKQAQLEKELS-AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406
Score = 33.5 bits (75), Expect = 0.63
Identities = 31/123 (25%), Positives = 56/123 (45%), Gaps = 15/123 (12%)
Query: 471 ETQARLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEE-------QLNDLTELHQNEI 523
E + RL+ + + + + L E+ + + L + Q+ +L EL Q +
Sbjct: 1029 ELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQT-V 1087
Query: 524 LNLKQELASMEEKIAY------QSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGL 577
LK++LA E++ A ++ R LEA + +SK+E Q Q+QQ Q + L
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ-EQADSL 1146
Query: 578 ENA 580
E +
Sbjct: 1147 ERS 1149
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 44.3 bits (103), Expect = 4e-04
Identities = 72/375 (19%), Positives = 148/375 (39%), Gaps = 35/375 (9%)
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
D ++G+ + + K L++ KL +K+AQ + D E +L K++ I
Sbjct: 1038 DDLEGSLEQE--KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF-EIS 1094
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQN---------GIPRQPKDVFRDMHQGL 329
+ K + A I QLQKK++ ++ E+E+ +Q D+ R++ + +
Sbjct: 1095 NLQSKIEDEQALGI-QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-I 1152
Query: 330 KDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSA------ 383
+ + G + ++ K + F + A + A+L + S
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 384 -DNIPNLKDSLEEGQVDDAGKALGVISNFQ--SSPKYGSEEDCSSATS--GSVGANSTTG 438
DN+ +K LE+ + + + + SN + S K E+ C + + +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272
Query: 439 GIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF----ETLKEHYQRDY--- 491
+ +++ L +S F L E + + +R +++F E LK + +
Sbjct: 1273 QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 492 SLIMQTLQEERYRCERLEEQLNDLTELH---QNEILNLKQELASMEEKIAYQSYERARDI 548
+ + LQ R+ C+ L EQ + E Q + E+A K + +R ++
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 549 QEALEACQTRISKME 563
+EA + R+ E
Sbjct: 1393 EEAKKKLAQRLQAAE 1407
Score = 38.1 bits (87), Expect = 0.026
Identities = 101/481 (20%), Positives = 190/481 (39%), Gaps = 62/481 (12%)
Query: 144 EMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIER-LEVSSLA 202
E + ++ + RS + + S +E A A +A E +++ R LE ++L
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 203 QTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEY 262
++A +T H DSV + + ++QK+ K ++K+ NV
Sbjct: 1191 HEATA---ATLRKKHADSVAELGEQIDN---LQRVKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 263 LKLANSADKQQAARIKQVFEKKNQKSAQTIL---------QLQKKLEHYHRKLREVE--- 310
K + +K Q+ E K+++ Q L +LQ + + R+L E E
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 311 ------QNGIPRQPKDVFRDMHQGLKDVGAKVTGF--SEGVVDSVKGGFSSFSQATHSAA 362
+ +Q +++ R + + +K A S D ++ + ++
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 363 GAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQS-SPKYGSEE 421
A+ E+A R K+ D I ++ LEE + A + + ++ + K S E
Sbjct: 1365 RALSKANTEVAQW-RTKY-ETDAIQRTEE-LEEAKKKLAQRLQAAEEHVEAVNAKCASLE 1421
Query: 422 DCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEI-QEIRETQARLEESF 480
V + V +++ LD + FD +L E Q+ ET A LE S
Sbjct: 1422 KTKQRLQNEVEDLM----LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 481 ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ 540
+ + +L E ++ + E+ D E + E NL+QE++ + E+IA
Sbjct: 1478 KEAR------------SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA-- 1523
Query: 541 SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATA--RNLLGKLINILLAVMA 598
E + I E + K++ Q +Q++ LE A A + GK++ I L +
Sbjct: 1524 --EGGKRIHE--------LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 599 V 599
V
Sbjct: 1574 V 1574
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 44.3 bits (103), Expect = 4e-04
Identities = 72/375 (19%), Positives = 148/375 (39%), Gaps = 35/375 (9%)
Query: 219 DSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIK 278
D ++G+ + + K L++ KL +K+AQ + D E +L K++ I
Sbjct: 1038 DDLEGSLEQE--KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF-EIS 1094
Query: 279 QVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQN---------GIPRQPKDVFRDMHQGL 329
+ K + A I QLQKK++ ++ E+E+ +Q D+ R++ + +
Sbjct: 1095 NLQSKIEDEQALGI-QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-I 1152
Query: 330 KDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSA------ 383
+ + G + ++ K + F + A + A+L + S
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212
Query: 384 -DNIPNLKDSLEEGQVDDAGKALGVISNFQ--SSPKYGSEEDCSSATS--GSVGANSTTG 438
DN+ +K LE+ + + + + SN + S K E+ C + + +
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272
Query: 439 GIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF----ETLKEHYQRDY--- 491
+ +++ L +S F L E + + +R +++F E LK + +
Sbjct: 1273 QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 492 SLIMQTLQEERYRCERLEEQLNDLTELH---QNEILNLKQELASMEEKIAYQSYERARDI 548
+ + LQ R+ C+ L EQ + E Q + E+A K + +R ++
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 549 QEALEACQTRISKME 563
+EA + R+ E
Sbjct: 1393 EEAKKKLAQRLQAAE 1407
Score = 38.1 bits (87), Expect = 0.026
Identities = 101/481 (20%), Positives = 190/481 (39%), Gaps = 62/481 (12%)
Query: 144 EMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIER-LEVSSLA 202
E + ++ + RS + + S +E A A +A E +++ R LE ++L
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1190
Query: 203 QTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEY 262
++A +T H DSV + + ++QK+ K ++K+ NV
Sbjct: 1191 HEATA---ATLRKKHADSVAELGEQIDN---LQRVKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 263 LKLANSADKQQAARIKQVFEKKNQKSAQTIL---------QLQKKLEHYHRKLREVE--- 310
K + +K Q+ E K+++ Q L +LQ + + R+L E E
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304
Query: 311 ------QNGIPRQPKDVFRDMHQGLKDVGAKVTGF--SEGVVDSVKGGFSSFSQATHSAA 362
+ +Q +++ R + + +K A S D ++ + ++
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364
Query: 363 GAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQS-SPKYGSEE 421
A+ E+A R K+ D I ++ LEE + A + + ++ + K S E
Sbjct: 1365 RALSKANTEVAQW-RTKY-ETDAIQRTEE-LEEAKKKLAQRLQAAEEHVEAVNAKCASLE 1421
Query: 422 DCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEI-QEIRETQARLEESF 480
V + V +++ LD + FD +L E Q+ ET A LE S
Sbjct: 1422 KTKQRLQNEVEDLM----LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 481 ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ 540
+ + +L E ++ + E+ D E + E NL+QE++ + E+IA
Sbjct: 1478 KEAR------------SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA-- 1523
Query: 541 SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATA--RNLLGKLINILLAVMA 598
E + I E + K++ Q +Q++ LE A A + GK++ I L +
Sbjct: 1524 --EGGKRIHE--------LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 599 V 599
V
Sbjct: 1574 V 1574
>gi|219555718 synaptonemal complex central element protein 1 isoform
4 [Homo sapiens]
Length = 351
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/140 (22%), Positives = 63/140 (45%), Gaps = 3/140 (2%)
Query: 433 ANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYS 492
A T G + + +T + ++ ++Q++ + R+E + E Q+
Sbjct: 10 AEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINE-VQQAKK 68
Query: 493 LIMQTLQEERYRCERLEEQLNDL--TELHQNEILNLKQELASMEEKIAYQSYERARDIQE 550
+ L E R CE L+++L+ L ++H EIL+ KQE + + A
Sbjct: 69 KANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHT 128
Query: 551 ALEACQTRISKMELQQQQQQ 570
L+ C+ RIS + LQ ++++
Sbjct: 129 MLQECKERISALNLQIEEEK 148
>gi|219555716 synaptonemal complex central element protein 1 isoform
3 [Homo sapiens]
Length = 318
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/140 (22%), Positives = 63/140 (45%), Gaps = 3/140 (2%)
Query: 433 ANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYS 492
A T G + + +T + ++ ++Q++ + R+E + E Q+
Sbjct: 10 AEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINE-VQQAKK 68
Query: 493 LIMQTLQEERYRCERLEEQLNDL--TELHQNEILNLKQELASMEEKIAYQSYERARDIQE 550
+ L E R CE L+++L+ L ++H EIL+ KQE + + A
Sbjct: 69 KANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHT 128
Query: 551 ALEACQTRISKMELQQQQQQ 570
L+ C+ RIS + LQ ++++
Sbjct: 129 MLQECKERISALNLQIEEEK 148
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.126 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,196,463
Number of Sequences: 37866
Number of extensions: 1048456
Number of successful extensions: 7377
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 563
Number of HSP's that attempted gapping in prelim test: 5678
Number of HSP's gapped (non-prelim): 2166
length of query: 653
length of database: 18,247,518
effective HSP length: 109
effective length of query: 544
effective length of database: 14,120,124
effective search space: 7681347456
effective search space used: 7681347456
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.