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Search of human proteins with 18921093
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18921093 transient receptor potential cation channel,
subfamily M, member 6 [Homo sapiens]
(2022 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18921093 transient receptor potential cation channel, subfami... 4105 0.0
gi|148612863 transient receptor potential cation channel, subfam... 1499 0.0
gi|154091314 transient receptor potential cation channel, subfam... 1358 0.0
gi|154091320 transient receptor potential cation channel, subfam... 1268 0.0
gi|154091318 transient receptor potential cation channel, subfam... 1265 0.0
gi|154091312 transient receptor potential cation channel, subfam... 1260 0.0
gi|154091316 transient receptor potential cation channel, subfam... 1257 0.0
gi|154091308 transient receptor potential cation channel, subfam... 1255 0.0
gi|154091310 transient receptor potential cation channel, subfam... 1252 0.0
gi|94538366 transient receptor potential cation channel, subfami... 831 0.0
gi|21314671 transient receptor potential cation channel, subfami... 465 e-130
gi|4507689 transient receptor potential cation channel, subfamil... 459 e-128
gi|11225266 transient receptor potential cation channel, subfami... 427 e-119
gi|45935368 transient receptor potential cation channel, subfami... 313 1e-84
gi|55953096 transient receptor potential cation channel, subfami... 300 1e-80
gi|109689695 transient receptor potential cation channel, subfam... 216 2e-55
gi|209863032 transient receptor potential cation channel, subfam... 84 1e-15
gi|209863026 transient receptor potential cation channel, subfam... 84 1e-15
gi|209863024 transient receptor potential cation channel, subfam... 84 1e-15
gi|7706747 transient receptor potential cation channel, subfamil... 84 1e-15
gi|209863030 transient receptor potential cation channel, subfam... 79 6e-14
gi|148596992 heart alpha-kinase [Homo sapiens] 76 3e-13
gi|6912736 transient receptor potential cation channel, subfamil... 73 3e-12
gi|209863028 transient receptor potential cation channel, subfam... 71 9e-12
gi|9558749 elongation factor-2 kinase [Homo sapiens] 68 8e-11
gi|9966865 transient receptor potential cation channel, subfamil... 58 1e-07
gi|194733735 transient receptor potential cation channel, subfam... 55 5e-07
gi|4507687 transient receptor potential cation channel, subfamil... 55 5e-07
gi|5730102 transient receptor potential cation channel, subfamil... 54 1e-06
gi|156151443 alpha-kinase 1 [Homo sapiens] 54 2e-06
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 4105 bits (10646), Expect = 0.0
Identities = 2022/2022 (100%), Positives = 2022/2022 (100%)
Query: 1 MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGD 60
MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGD
Sbjct: 1 MKEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGD 60
Query: 61 HAGIDYSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKL 120
HAGIDYSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKL
Sbjct: 61 HAGIDYSWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKL 120
Query: 121 DHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGIN 180
DHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGIN
Sbjct: 121 DHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGIN 180
Query: 181 TGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTT 240
TGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTT
Sbjct: 181 TGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTT 240
Query: 241 LNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVI 300
LNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVI
Sbjct: 241 LNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVI 300
Query: 301 LSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLK 360
LSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLK
Sbjct: 301 LSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLK 360
Query: 361 QSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR 420
QSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR
Sbjct: 361 QSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDR 420
Query: 421 VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYN 480
VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYN
Sbjct: 421 VDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYN 480
Query: 481 TKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNN 540
TKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNN
Sbjct: 481 TKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNN 540
Query: 541 LYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPE 600
LYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPE
Sbjct: 541 LYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPE 600
Query: 601 STGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDD 660
STGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDD
Sbjct: 601 STGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDD 660
Query: 661 ASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFV 720
ASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFV
Sbjct: 661 ASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFV 720
Query: 721 SHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFM 780
SHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFM
Sbjct: 721 SHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFM 780
Query: 781 WYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIV 840
WYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIV
Sbjct: 781 WYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIV 840
Query: 841 KFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQ 900
KFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQ
Sbjct: 841 KFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQ 900
Query: 901 KVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVN 960
KVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVN
Sbjct: 901 KVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVN 960
Query: 961 QHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWM 1020
QHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWM
Sbjct: 961 QHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWM 1020
Query: 1021 IYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080
IYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS
Sbjct: 1021 IYGEVYAGEIDVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080
Query: 1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSK 1140
NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSK
Sbjct: 1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSK 1140
Query: 1141 EDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDS 1200
EDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDS
Sbjct: 1141 EDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDS 1200
Query: 1201 LLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAE 1260
LLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAE
Sbjct: 1201 LLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCKKLPHSWSNVICAE 1260
Query: 1261 VLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQ 1320
VLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQ
Sbjct: 1261 VLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEITNSKREATNVRNDQERQ 1320
Query: 1321 ETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQ 1380
ETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQ
Sbjct: 1321 ETQSSIVVSGVSPNRQAHSKYGQFLLVPSNLKRVPFSAETVLPLSRPSVPDVLATEQDIQ 1380
Query: 1381 TEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPL 1440
TEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPL
Sbjct: 1381 TEVLVHLTGQTPVVSDWASVDEPKEKHEPIAHLLDGQDKAEQVLPTLSCTPEPMTMSSPL 1440
Query: 1441 SQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLS 1500
SQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLS
Sbjct: 1441 SQAKIMQTGGGYVNWAFSEGDETGVFSIKKKWQTCLPSTCDSDSSRSEQHQKQAQDSSLS 1500
Query: 1501 DNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLS 1560
DNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLS
Sbjct: 1501 DNSTRSAQSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLS 1560
Query: 1561 GSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEE 1620
GSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEE
Sbjct: 1561 GSSEIGQGAWVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEE 1620
Query: 1621 EYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTN 1680
EYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTN
Sbjct: 1621 EYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTN 1680
Query: 1681 LNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITV 1740
LNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITV
Sbjct: 1681 LNRNSLLKSSIGVDKISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITV 1740
Query: 1741 YRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQV 1800
YRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQV
Sbjct: 1741 YRLEESSPLNLDKSMSSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQV 1800
Query: 1801 FIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLE 1860
FIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLE
Sbjct: 1801 FIVKSFLPEVVRTWHKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLE 1860
Query: 1861 VFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELL 1920
VFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELL
Sbjct: 1861 VFLIYCHSANQWLTIEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELL 1920
Query: 1921 VLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDL 1980
VLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDL
Sbjct: 1921 VLDLQGVGENLTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDL 1980
Query: 1981 KRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL 2022
KRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL
Sbjct: 1981 KRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQL 2022
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 1499 bits (3881), Expect = 0.0
Identities = 760/1254 (60%), Positives = 936/1254 (74%), Gaps = 42/1254 (3%)
Query: 12 SQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTIS 71
SQKSWI+ KREC IIPSSK+PHRC P CQ+CQ L+RC+CGRL+ HA S +
Sbjct: 2 SQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMK 61
Query: 72 AAKGKES-------EQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLL 124
+ K E+WSVEKHT +SPTD +G INFQ G H++ AKY+R SYDTK + +L
Sbjct: 62 YSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
Query: 125 HLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVS 184
L+LKEW+MELPKLVISVHGG+Q F + + K++ +GL+KAA TTGAWI+T G+NTGV+
Sbjct: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
Query: 185 KHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPLSKLTTLNSM 244
KHVGDALK H+S S RKI T+GI PWGVIEN+ DL+G+DVV YQTL NPLSKL LN++
Sbjct: 182 KHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNL 241
Query: 245 HSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVW 304
HSHFIL DDGTVGKYG E++LRR LEK ++ Q+IH R QGVPVV L+ EGGPNVIL+V
Sbjct: 242 HSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVL 301
Query: 305 ETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQS 362
E +++ PVVVCEGTGRAADLLA+ HK + G L + +II I+ TFNF ++
Sbjct: 302 EYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEA 361
Query: 363 KHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVD 422
HLFQ LMECM ++ IT+F S+E QD+D+AILTALLKGTN SA +QL L +AWDRVD
Sbjct: 362 LHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVD 421
Query: 423 IAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTK 482
IAK H+ +Y Q W +LEQAM DALVMDRV FVKLLIE GV++H+FLTIPRLEELYNTK
Sbjct: 422 IAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTK 481
Query: 483 QGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNL- 541
QGPTN +L HLV+DVKQ L GY+ITLIDIGLV+EYL+G YR YTRK FR +YN+L
Sbjct: 482 QGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLG 541
Query: 542 -------------YRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK 588
+ + S GNR + E H+ FI+TAQPY+ K +++ +K
Sbjct: 542 GNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKK 601
Query: 589 KSKEQNVS-DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRA 647
++K++ V DDPE+ F YP N+LL+WA LMKRQ MA F WQHGEE+ KA++AC +YR+
Sbjct: 602 RTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRS 661
Query: 648 MAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTC 707
MA+EAK+S +VDD SEELK YS FGQLA++LLE++F+Q+E MAM LLTYEL+NWSNSTC
Sbjct: 662 MAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTC 721
Query: 708 LKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAE 767
LKLAVS LRPFV+HTCTQMLL+DMWMGRL MRKNSW K+I+SI++PP IL LE+K+KAE
Sbjct: 722 LKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAE 781
Query: 768 MSHVPQSQD-FQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLP 826
MSH+PQSQD Q S+ N + E ++ + R D +N+ ++ + LP
Sbjct: 782 MSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNE-MEIQMKSKKLP 840
Query: 827 WTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEV 886
TRK Y FY APIVKFWF T+AYL FLML+T+ VLV+M+ PSVQEW+V YIFT AIE
Sbjct: 841 ITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEK 900
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWG---------DPPFHTA 937
VREI +SE GK QK+KVW S+Y+N+++T+AI F GF LR+G D A
Sbjct: 901 VREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVA 960
Query: 938 GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKA 997
GRLIYC++IIFW+ RLLDF AVNQ AGPYV MI KM ANMFYIV+IMA+VLLSFGV RKA
Sbjct: 961 GRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKA 1020
Query: 998 ILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ----PSCPPGSFLTPFLQAVY 1053
IL P E PSW+LA+DIVF PYWMI+GEVYA EIDVC++ C PG++LTPFLQAVY
Sbjct: 1021 ILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVY 1080
Query: 1054 LFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGL 1113
LFVQYIIMVNLLIAFFNNVYL +++ISN +WKY RY +IM YHEKP LPPPLI+LSH+
Sbjct: 1081 LFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVS 1140
Query: 1114 LLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERI 1173
L CC +++ G KL+L++ED KKLHDFEEQCVE YF+EK + + EERI
Sbjct: 1141 L---FCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERI 1197
Query: 1174 RVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSA 1227
RVT ERV +M Q+KE+ ++V++IK SL SLDSQ+GHLQDLSALTVDTLK L+A
Sbjct: 1198 RVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTA 1251
Score = 457 bits (1175), Expect = e-128
Identities = 219/295 (74%), Positives = 254/295 (86%), Gaps = 1/295 (0%)
Query: 1696 ISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSM 1755
+++ K + +++YSA+ERNNLMRLSQ+IPFTPV GE +TVYRLEESSP L+ SM
Sbjct: 1541 LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPP-RGEPVTVYRLEESSPNILNNSM 1599
Query: 1756 SSWSQRGRAAMIQVLSREEMDGGLRKAMRVVSTWSEDDILKPGQVFIVKSFLPEVVRTWH 1815
SSWSQ G A I+ LS+EEM GGLR+A++V TWSE DILK G ++I+KSFLPEVV TW
Sbjct: 1600 SSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWS 1659
Query: 1816 KIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSANQWLTI 1875
I++E TVLHLCLREIQQQRAAQKL + FNQ+KP++IPY+PRFLEVFL+YCHSA QW +
Sbjct: 1660 SIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAV 1719
Query: 1876 EKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1935
E+ MTGEFRKYNNNNGDEI PTNTLEE+MLAFSHWTYEYTRGELLVLDLQGVGENLTDPS
Sbjct: 1720 EECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPS 1779
Query: 1936 VIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERI 1990
VIK E K+S MVFGPANLGEDAI+NF AKHHCNSCCRKLKLPDLKRNDY+P++I
Sbjct: 1780 VIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKI 1834
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 1358 bits (3515), Expect = 0.0
Identities = 690/1278 (53%), Positives = 912/1278 (71%), Gaps = 77/1278 (6%)
Query: 5 PVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGI 64
P + L++QKSWI+ F KREC IIPS+K+PHRC CGRLIG H G+
Sbjct: 53 PSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCC-------------CGRLIGQHVGL 99
Query: 65 DYSWTISAAKGKES---------EQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTS 115
S ++ + ES E+WS+ KHT SPTD FGTI FQ G H++ A Y+R S
Sbjct: 100 TPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVS 159
Query: 116 YDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWII 175
+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TTGAWI
Sbjct: 160 FDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIF 219
Query: 176 TEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQTLDNPL 235
T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT+ NP+
Sbjct: 220 TGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPM 279
Query: 236 SKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEG 295
SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV L+VEG
Sbjct: 280 SKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEG 339
Query: 296 GPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQN 353
GPNVI V E ++D PVVVC+G+GRA+D+LAF HK+ + G++ ++++++ IQ
Sbjct: 340 GPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQK 399
Query: 354 TFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASEQLN 413
TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA +QL+
Sbjct: 400 TFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLS 459
Query: 414 LAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIP 473
LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HRFLTI
Sbjct: 460 LALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTIS 519
Query: 474 RLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKH 533
RLEELYNT+ GP+NT L+HLV+DVK+ L YRI+LIDIGLV+EYL+G AYR NYTRK
Sbjct: 520 RLEELYNTRHGPSNT-LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKR 578
Query: 534 FRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK--KSK 591
FR LY+NL+ G + A L E I L + RK K +
Sbjct: 579 FRTLYHNLF----------GPKRPKALKLLG------------MEDDIPLRRGRKTTKKR 616
Query: 592 EQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAM 648
E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHGEEA KA++AC L +AM
Sbjct: 617 EEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAM 676
Query: 649 AHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCL 708
AHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++AM LLTYEL+NWSN+TCL
Sbjct: 677 AHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCL 736
Query: 709 KLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKSKAEM 768
+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I+LPP+IL+LEFK+K +M
Sbjct: 737 QLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDM 796
Query: 769 SHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RGHDEKLDENQHFGLESGH 822
++ Q+Q+ +++ +KE +E D+E R + E + ++S H
Sbjct: 797 PYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRNNGESSRKKDEEEVQSKH 853
Query: 823 QHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTN 882
+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+ PS QEW+V YIFT
Sbjct: 854 RLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTL 913
Query: 883 AIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIY 942
IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G +LR D PF + GR+IY
Sbjct: 914 GIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIY 973
Query: 943 CIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPK 1002
C++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM +VL+SFGVAR+AIL P
Sbjct: 974 CVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPN 1033
Query: 1003 EPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ------------PSCPPGSFLTPFLQ 1050
E PSW LA++I + PYWMIYGEV+A +ID Q P C G+++ P +
Sbjct: 1034 EEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIM 1093
Query: 1051 AVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSH 1110
A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IMT+HE+P LPPPLI+ SH
Sbjct: 1094 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1153
Query: 1111 VGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCS 1168
+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEEQC+E+YF EK + N S
Sbjct: 1154 MTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSS 1213
Query: 1169 CEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLKVLSAV 1228
+ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L+DL L+ L+ +
Sbjct: 1214 NDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGL 1273
Query: 1229 DTLQEDEALLAKRKHSTC 1246
+ + ++ + R S C
Sbjct: 1274 ERAESNK--IRSRTSSDC 1289
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 1268 bits (3282), Expect = 0.0
Identities = 639/1163 (54%), Positives = 847/1163 (72%), Gaps = 55/1163 (4%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 291 LVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEII 348
L+VEGGPNVI V E ++D PV VVC+G+GRA+D+LAF HK+ + G++ ++++++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 349 CMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSA 408
IQ TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
+QL+LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HR
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSN 528
FLTI RLEELYNT+ GP+NTL +HLV+DVK+ L YRI+LIDIGLV+EYL+G AYR N
Sbjct: 362 FLTISRLEELYNTRHGPSNTL-YHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420
Query: 529 YTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK 588
YTRK FR LY+NL+ G + A L E I L + RK
Sbjct: 421 YTRKRFRTLYHNLF----------GPKRPKALKLLGM------------EDDIPLRRGRK 458
Query: 589 --KSKEQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACI 643
K +E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHGEEA KA++AC
Sbjct: 459 TTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 518
Query: 644 LYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWS 703
L +AMAHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++AM LLTYEL+NWS
Sbjct: 519 LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 578
Query: 704 NSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFK 763
N+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I+LPP+IL+LEFK
Sbjct: 579 NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 638
Query: 764 SKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RGHDEKLDENQHFG 817
+K +M ++ Q+Q+ +++ +KE +E D+E R + E +
Sbjct: 639 NKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRNNGESSRKKDEEE 695
Query: 818 LESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSI 877
++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+ PS QEW+V
Sbjct: 696 VQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVIS 755
Query: 878 YIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTA 937
YIFT IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G +LR D PF +
Sbjct: 756 YIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSD 815
Query: 938 GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKA 997
GR+IYC++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM +VL+SFGVAR+A
Sbjct: 816 GRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQA 875
Query: 998 ILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ------------PSCPPGSFL 1045
IL P E PSW LA++I + PYWMIYGEV+A +ID Q P C G+++
Sbjct: 876 ILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWI 935
Query: 1046 TPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPL 1105
P + A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IMT+HE+P LPPPL
Sbjct: 936 VPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPL 995
Query: 1106 ILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKME 1163
I+ SH+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEEQC+E+YF EK +
Sbjct: 996 IIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDD 1055
Query: 1164 DVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223
N S +ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L+DL L+
Sbjct: 1056 RFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALE 1115
Query: 1224 VLSAVDTLQEDEALLAKRKHSTC 1246
L+ ++ + ++ + R S C
Sbjct: 1116 RLTGLERAESNK--IRSRTSSDC 1136
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 1265 bits (3274), Expect = 0.0
Identities = 636/1163 (54%), Positives = 843/1163 (72%), Gaps = 65/1163 (5%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 291 LVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEII 348
L+VEGGPNVI V E ++D PV VVC+G+GRA+D+LAF HK+ + G++ ++++++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 349 CMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSA 408
IQ TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
+QL+LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HR
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIGLVVEYLIGRAYRSN 528
FLTI RLEELYNT+ GP+NTL +HLV+DVK+ L YRI+LIDIGLV+EYL+G AYR N
Sbjct: 362 FLTISRLEELYNTRHGPSNTL-YHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCN 420
Query: 529 YTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHKSRK 588
YTRK FR LY+NL+ K I L + RK
Sbjct: 421 YTRKRFRTLYHNLFGP--------------------------------KRDDIPLRRGRK 448
Query: 589 --KSKEQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACI 643
K +E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHGEEA KA++AC
Sbjct: 449 TTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACK 508
Query: 644 LYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWS 703
L +AMAHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++AM LLTYEL+NWS
Sbjct: 509 LCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 568
Query: 704 NSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFK 763
N+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I+LPP+IL+LEFK
Sbjct: 569 NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFK 628
Query: 764 SKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RGHDEKLDENQHFG 817
+K +M ++ Q+Q+ +++ +KE +E D+E R + E +
Sbjct: 629 NKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRNNGESSRKKDEEE 685
Query: 818 LESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSI 877
++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+ PS QEW+V
Sbjct: 686 VQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVIS 745
Query: 878 YIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTA 937
YIFT IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G +LR D PF +
Sbjct: 746 YIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSD 805
Query: 938 GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKA 997
GR+IYC++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM +VL+SFGVAR+A
Sbjct: 806 GRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQA 865
Query: 998 ILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ------------PSCPPGSFL 1045
IL P E PSW LA++I + PYWMIYGEV+A +ID Q P C G+++
Sbjct: 866 ILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWI 925
Query: 1046 TPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPL 1105
P + A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IMT+HE+P LPPPL
Sbjct: 926 VPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPL 985
Query: 1106 ILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKME 1163
I+ SH+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEEQC+E+YF EK +
Sbjct: 986 IIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDD 1045
Query: 1164 DVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSALTVDTLK 1223
N S +ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L+DL L+
Sbjct: 1046 RFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALE 1105
Query: 1224 VLSAVDTLQEDEALLAKRKHSTC 1246
L+ ++ + ++ + R S C
Sbjct: 1106 RLTGLERAESNK--IRSRTSSDC 1126
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 1260 bits (3261), Expect = 0.0
Identities = 639/1175 (54%), Positives = 847/1175 (72%), Gaps = 67/1175 (5%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 291 LVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEII 348
L+VEGGPNVI V E ++D PV VVC+G+GRA+D+LAF HK+ + G++ ++++++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 349 CMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSA 408
IQ TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
+QL+LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HR
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDVKQH------------TLLSGYRITLIDIGLV 516
FLTI RLEELYNT+ GP+NTL +HLV+DVK+ L YRI+LIDIGLV
Sbjct: 362 FLTISRLEELYNTRHGPSNTL-YHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 517 VEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKF 576
+EYL+G AYR NYTRK FR LY+NL+ G + A L
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLF----------GPKRPKALKLLGM----------- 459
Query: 577 KEKSIVLHKSRK--KSKEQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHG 631
E I L + RK K +E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHG
Sbjct: 460 -EDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHG 518
Query: 632 EEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMA 691
EEA KA++AC L +AMAHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++A
Sbjct: 519 EEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLA 578
Query: 692 MTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISI 751
M LLTYEL+NWSN+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I
Sbjct: 579 MKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGI 638
Query: 752 ILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RG 805
+LPP+IL+LEFK+K +M ++ Q+Q+ +++ +KE +E D+E R
Sbjct: 639 LLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRN 695
Query: 806 HDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQ 865
+ E + ++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+
Sbjct: 696 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 755
Query: 866 PQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGF 925
PS QEW+V YIFT IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G
Sbjct: 756 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 815
Query: 926 VLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMA 985
+LR D PF + GR+IYC++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM
Sbjct: 816 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 875
Query: 986 IVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ--------- 1036
+VL+SFGVAR+AIL P E PSW LA++I + PYWMIYGEV+A +ID Q
Sbjct: 876 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 935
Query: 1037 ---PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIM 1093
P C G+++ P + A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IM
Sbjct: 936 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 995
Query: 1094 TYHEKPWLPPPLILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEE 1151
T+HE+P LPPPLI+ SH+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEE
Sbjct: 996 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1055
Query: 1152 QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHL 1211
QC+E+YF EK + N S +ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L
Sbjct: 1056 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1115
Query: 1212 QDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTC 1246
+DL L+ L+ ++ + ++ + R S C
Sbjct: 1116 EDLIGRMATALERLTGLERAESNK--IRSRTSSDC 1148
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 1257 bits (3253), Expect = 0.0
Identities = 636/1175 (54%), Positives = 843/1175 (71%), Gaps = 77/1175 (6%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 291 LVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEII 348
L+VEGGPNVI V E ++D PV VVC+G+GRA+D+LAF HK+ + G++ ++++++
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLL 241
Query: 349 CMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSA 408
IQ TF ++ Q++HLF ILMECM ++ IT+F SE QD+DLAILTALLKG N SA
Sbjct: 242 VTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASA 301
Query: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
+QL+LA+AW+RVDIA+ I IY Q W +LEQAM DALV+DRVDFVKLLIE GV++HR
Sbjct: 302 PDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHR 361
Query: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDVKQH------------TLLSGYRITLIDIGLV 516
FLTI RLEELYNT+ GP+NTL +HLV+DVK+ L YRI+LIDIGLV
Sbjct: 362 FLTISRLEELYNTRHGPSNTL-YHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLV 420
Query: 517 VEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKF 576
+EYL+G AYR NYTRK FR LY+NL+
Sbjct: 421 IEYLMGGAYRCNYTRKRFRTLYHNLFGP-------------------------------- 448
Query: 577 KEKSIVLHKSRK--KSKEQNVS---DDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHG 631
K I L + RK K +E+ V DDPE F +P+++L+VWAVLMKRQKMA+FFWQHG
Sbjct: 449 KRDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHG 508
Query: 632 EEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMA 691
EEA KA++AC L +AMAHEA E+ MVDD S+EL + S+ FGQLA++LL++++KQ+E++A
Sbjct: 509 EEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLA 568
Query: 692 MTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISI 751
M LLTYEL+NWSN+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+MRKNS LK+I+ I
Sbjct: 569 MKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGI 628
Query: 752 ILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLE------RG 805
+LPP+IL+LEFK+K +M ++ Q+Q+ +++ +KE +E D+E R
Sbjct: 629 LLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---EEEDMELTAMLGRN 685
Query: 806 HDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQ 865
+ E + ++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +LMLF Y VLV+M+
Sbjct: 686 NGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKME 745
Query: 866 PQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGF 925
PS QEW+V YIFT IE +REI +SEPGK QKVKVW+ EYWN+T+ +AI LFS G
Sbjct: 746 RWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGM 805
Query: 926 VLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMA 985
+LR D PF + GR+IYC++II+W+ RLLD F VN++ GPYV MI KM +M Y VIIM
Sbjct: 806 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 865
Query: 986 IVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ--------- 1036
+VL+SFGVAR+AIL P E PSW LA++I + PYWMIYGEV+A +ID Q
Sbjct: 866 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKI 925
Query: 1037 ---PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIM 1093
P C G+++ P + A YL V I++VNLLIA FNN + +++SISN +WK+ RY+ IM
Sbjct: 926 IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIM 985
Query: 1094 TYHEKPWLPPPLILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYLSKEDLKKLHDFEE 1151
T+HE+P LPPPLI+ SH+ ++ + LCC H D +E D GLKL+++ ++LKK+HDFEE
Sbjct: 986 TFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEE 1045
Query: 1152 QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQVGHL 1211
QC+E+YF EK + N S +ERIRVTSERV M +L+E+NE+ +K SL ++D ++ L
Sbjct: 1046 QCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQL 1105
Query: 1212 QDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTC 1246
+DL L+ L+ ++ + ++ + R S C
Sbjct: 1106 EDLIGRMATALERLTGLERAESNK--IRSRTSSDC 1138
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 1255 bits (3248), Expect = 0.0
Identities = 641/1188 (53%), Positives = 849/1188 (71%), Gaps = 80/1188 (6%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCR--------S 282
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R S
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 283 R-----------------QGVPVVGLVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAA 323
R QGVPVV L+VEGGPNVI V E ++D PV VVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 324 DLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFD 383
D+LAF HK+ + G++ ++++++ IQ TF ++ Q++HLF ILMECM ++ IT+F
Sbjct: 242 DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301
Query: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
SE QD+DLAILTALLKG N SA +QL+LA+AW+RVDIA+ I IY Q W +LEQA
Sbjct: 302 MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361
Query: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
M DALV+DRVDFVKLLIE GV++HRFLTI RLEELYNT+ GP+NTL +HLV+DVK+ L
Sbjct: 362 MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL-YHLVRDVKKGNLP 420
Query: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
YRI+LIDIGLV+EYL+G AYR NYTRK FR LY+NL+ G + A L
Sbjct: 421 PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLF----------GPKRPKALKLL 470
Query: 564 HSQFIRTAQPYKFKEKSIVLHKSRK--KSKEQNVS---DDPESTGFLYPYNDLLVWAVLM 618
E I L + RK K +E+ V DDPE F +P+++L+VWAVLM
Sbjct: 471 GM------------EDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLM 518
Query: 619 KRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALD 678
KRQKMA+FFWQHGEEA KA++AC L +AMAHEA E+ MVDD S+EL + S+ FGQLA++
Sbjct: 519 KRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVE 578
Query: 679 LLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLK 738
LL++++KQ+E++AM LLTYEL+NWSN+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+
Sbjct: 579 LLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR 638
Query: 739 MRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVK 798
MRKNS LK+I+ I+LPP+IL+LEFK+K +M ++ Q+Q+ +++ +KE +
Sbjct: 639 MRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---E 695
Query: 799 EYDLE------RGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAF 852
E D+E R + E + ++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +
Sbjct: 696 EEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGY 755
Query: 853 LMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNL 912
LMLF Y VLV+M+ PS QEW+V YIFT IE +REI +SEPGK QKVKVW+ EYWN+
Sbjct: 756 LMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNV 815
Query: 913 TETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAK 972
T+ +AI LFS G +LR D PF + GR+IYC++II+W+ RLLD F VN++ GPYV MI K
Sbjct: 816 TDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGK 875
Query: 973 MTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV 1032
M +M Y VIIM +VL+SFGVAR+AIL P E PSW LA++I + PYWMIYGEV+A +ID
Sbjct: 876 MMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDP 935
Query: 1033 CSSQ------------PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080
Q P C G+++ P + A YL V I++VNLLIA FNN + +++SIS
Sbjct: 936 PCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSIS 995
Query: 1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYL 1138
N +WK+ RY+ IMT+HE+P LPPPLI+ SH+ ++ + LCC H D +E D GLKL++
Sbjct: 996 NQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFI 1055
Query: 1139 SKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIK 1198
+ ++LKK+HDFEEQC+E+YF EK + N S +ERIRVTSERV M +L+E+NE+ +K
Sbjct: 1056 TDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1115
Query: 1199 DSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTC 1246
SL ++D ++ L+DL L+ L+ ++ + ++ + R S C
Sbjct: 1116 ASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNK--IRSRTSSDC 1161
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 1252 bits (3240), Expect = 0.0
Identities = 638/1188 (53%), Positives = 845/1188 (71%), Gaps = 90/1188 (7%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCR--------S 282
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R S
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 283 R-----------------QGVPVVGLVVEGGPNVILSVWETVKDKDPV--VVCEGTGRAA 323
R QGVPVV L+VEGGPNVI V E ++D PV VVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 324 DLLAFTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFD 383
D+LAF HK+ + G++ ++++++ IQ TF ++ Q++HLF ILMECM ++ IT+F
Sbjct: 242 DILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFR 301
Query: 384 ADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQA 443
SE QD+DLAILTALLKG N SA +QL+LA+AW+RVDIA+ I IY Q W +LEQA
Sbjct: 302 MGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQA 361
Query: 444 MSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503
M DALV+DRVDFVKLLIE GV++HRFLTI RLEELYNT+ GP+NTL +HLV+DVK+ L
Sbjct: 362 MLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTL-YHLVRDVKKGNLP 420
Query: 504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTL 563
YRI+LIDIGLV+EYL+G AYR NYTRK FR LY+NL+
Sbjct: 421 PDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP------------------- 461
Query: 564 HSQFIRTAQPYKFKEKSIVLHKSRK--KSKEQNVS---DDPESTGFLYPYNDLLVWAVLM 618
K I L + RK K +E+ V DDPE F +P+++L+VWAVLM
Sbjct: 462 -------------KRDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLM 508
Query: 619 KRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALD 678
KRQKMA+FFWQHGEEA KA++AC L +AMAHEA E+ MVDD S+EL + S+ FGQLA++
Sbjct: 509 KRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVE 568
Query: 679 LLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLK 738
LL++++KQ+E++AM LLTYEL+NWSN+TCL+LAV+ R F++HTC+QMLLTDMWMGRL+
Sbjct: 569 LLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR 628
Query: 739 MRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVK 798
MRKNS LK+I+ I+LPP+IL+LEFK+K +M ++ Q+Q+ +++ +KE +
Sbjct: 629 MRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEK---E 685
Query: 799 EYDLE------RGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAF 852
E D+E R + E + ++S H+ +P RK+YEFY+APIVKFWFYT+AY+ +
Sbjct: 686 EEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGY 745
Query: 853 LMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNL 912
LMLF Y VLV+M+ PS QEW+V YIFT IE +REI +SEPGK QKVKVW+ EYWN+
Sbjct: 746 LMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNV 805
Query: 913 TETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAK 972
T+ +AI LFS G +LR D PF + GR+IYC++II+W+ RLLD F VN++ GPYV MI K
Sbjct: 806 TDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGK 865
Query: 973 MTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV 1032
M +M Y VIIM +VL+SFGVAR+AIL P E PSW LA++I + PYWMIYGEV+A +ID
Sbjct: 866 MMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDP 925
Query: 1033 CSSQ------------PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080
Q P C G+++ P + A YL V I++VNLLIA FNN + +++SIS
Sbjct: 926 PCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSIS 985
Query: 1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPH--DQEEGDVGLKLYL 1138
N +WK+ RY+ IMT+HE+P LPPPLI+ SH+ ++ + LCC H D +E D GLKL++
Sbjct: 986 NQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFI 1045
Query: 1139 SKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIK 1198
+ ++LKK+HDFEEQC+E+YF EK + N S +ERIRVTSERV M +L+E+NE+ +K
Sbjct: 1046 TDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMK 1105
Query: 1199 DSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTC 1246
SL ++D ++ L+DL L+ L+ ++ + ++ + R S C
Sbjct: 1106 ASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNK--IRSRTSSDC 1151
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 831 bits (2146), Expect = 0.0
Identities = 429/831 (51%), Positives = 582/831 (70%), Gaps = 56/831 (6%)
Query: 438 DALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDV 497
+ALEQAM DALV+DRVDFVKLLIE GVN+ FLTIPRLEELYNT+ GP NTL H LV+DV
Sbjct: 459 NALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTL-HLLVRDV 517
Query: 498 KQHTLLSGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNE 557
K+ L Y I+LIDIGLV+EYL+G AYR NYTRK+FR LYNNL+ G +
Sbjct: 518 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLF----------GPKRP 567
Query: 558 SAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVS-DDPESTGFLYPYNDLLVWAV 616
A L + P K K+K K +KK +E ++ DDP + F YP+++L+VWAV
Sbjct: 568 KALKLLGME--DDEPPAKGKKK-----KKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAV 620
Query: 617 LMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLA 676
LMKRQKMA+F WQ GEE+ KA++AC LY+AMAHE+ ES +VDD S++L N SK FGQLA
Sbjct: 621 LMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLA 680
Query: 677 LDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGR 736
L+LL++++K +E++AM LLTYEL+NWSNSTCLKLAV+ R F++HTC+QMLLTDMWMGR
Sbjct: 681 LELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGR 740
Query: 737 LKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESAS 796
L+MRKN LK+I+ I+LPPTIL LEF++ + F + S +N ++
Sbjct: 741 LRMRKNPGLKVIMGILLPPTILFLEFRTYDD-----------FSYQTSKENEDGKEKEEE 789
Query: 797 VKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLF 856
+ + + G + +EN+H + +P K+ EFY+APIVKFWFYT++YL +L+LF
Sbjct: 790 NTDANADAGSRKGDEENEH----KKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLF 845
Query: 857 TYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETV 916
Y +LV M PS+QEW+V YI + A+E +REI +SEPGK +QK+KVW+ EYWN+T+ V
Sbjct: 846 NYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLV 905
Query: 917 AIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTAN 976
AI F G +LR + P+ GR+IYC+DIIFW+ R+LD F VN++ GPYV MI KM +
Sbjct: 906 AISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMID 965
Query: 977 MFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
M Y V+IM +VL+SFGVAR+AIL P+E PSW LAR+I + PYWMIYGEV+A +ID+ + +
Sbjct: 966 MLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAME 1025
Query: 1037 -----------------PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESI 1079
P C PG++LTP L A YL V I++VNLLIA FNN + +++SI
Sbjct: 1026 INPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSI 1085
Query: 1080 SNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRL---CCHRAPHDQEEGDVGLKL 1136
SN +WK+ RY+ IMT+H++P LPPP+I+LSH+ +++ RL C + DQEE D GLKL
Sbjct: 1086 SNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKL 1145
Query: 1137 YLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSF 1196
+LS E+LK+LH+FEEQCV+++F EK ++ S +ERIRVTSERV M +L+E+NE+ +F
Sbjct: 1146 FLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETF 1205
Query: 1197 IKDSLLSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEALLAKRKHSTCK 1247
+K SL ++D ++ L++LS V+ L+ L+ +D + D R S C+
Sbjct: 1206 MKTSLQTVDLRLAQLEELSNRMVNALENLAGID--RSDLIQARSRASSECE 1254
Score = 452 bits (1162), Expect = e-126
Identities = 215/395 (54%), Positives = 296/395 (74%), Gaps = 8/395 (2%)
Query: 51 RCYCGRLIGDHAGIDYSWTISAAKGK------ESEQWSVEKHTTKSPTDTFGTINFQDGE 104
RC CG+ H S T S + + + E+WSV KHT PTD++G + FQ G
Sbjct: 6 RCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGG 65
Query: 105 HTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLV 164
+++ A YIR SYDTK D LLHLM+K+W++ELPKL+ISVHGG+QNF M K K++F +GL+
Sbjct: 66 YSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLI 125
Query: 165 KAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDV 224
KAA TTGAWI T G++TGV HVGDALK HSS S ++ +GI PWG++EN+ DL+GKDV
Sbjct: 126 KAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDV 185
Query: 225 VCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQ 284
+YQT+ NPLSKL+ LN+ H+HFIL+D+GT+GKYG E+KLRR LEK++SLQKI+ R Q
Sbjct: 186 TRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQ 245
Query: 285 GVPVVGLVVEGGPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEGMLRPQ 342
GVP+VGLVVEGGPNV+ V E ++++ PVV+C+G+GRA+D+L+F HK+ + G++
Sbjct: 246 GVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINES 305
Query: 343 VKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLK 402
++E+++ IQ TFN++ QS LF I+MECM ++ +T+F SE QQD+++AILTALLK
Sbjct: 306 LREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLK 365
Query: 403 GTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKP 437
GTN+SA +QL+LA+AW+RVDIA+ I ++ HW P
Sbjct: 366 GTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPP 400
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 465 bits (1197), Expect = e-130
Identities = 350/1244 (28%), Positives = 595/1244 (47%), Gaps = 143/1244 (11%)
Query: 11 QSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTI 70
+ ++SWI +F K+ C+T I S +P C CGR H +
Sbjct: 5 EKEQSWIPKIFKKKTCTTFIVDSTDPGGTL-----------CQCGRPRTAHPAVAMEDAF 53
Query: 71 SAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKE 130
AA W + HTT+ PTD +G ++F G H+ ++R S T + L+ +
Sbjct: 54 GAAV---VTVWDSDAHTTEKPTDAYGELDFT-GAGRKHSNFLRLSDRTDPAAVYSLVTRT 109
Query: 131 WKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDA 190
W P LV+SV GG + + +++ +GLV+AA++TGAWI+T G++TG+ +HVG A
Sbjct: 110 WGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVA 169
Query: 191 LKSHSSHSL--RKIWTVGIPPWGVIENQRDLIGK--DVVCLYQTLDNPLSKLT-TLNSMH 245
++ H S K+ +G+ PWGV+ N+ LI Y+ +P + L+ +
Sbjct: 170 VRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNY 229
Query: 246 SHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQ-GVPVVGLVVEGGPNVILSVW 304
S F L DDGT G G E + R LE Y+S QK +PV+ L+++G ++ +
Sbjct: 230 SAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIE 289
Query: 305 ETVKDKDPVVVCEGTGRAADLLAFTHKHL-------ADEGMLRPQVKEEIICMIQNTFNF 357
+ + P ++ G+G AAD LA T + A +G R +++ F
Sbjct: 290 NATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIR-----------RF 338
Query: 358 SLKQSKHLFQILME-CMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSAS----EQL 412
K + Q +E M ++ +T++ ++ + ++ + +L AL+K S + ++L
Sbjct: 339 FPKGDLEVLQAQVERIMTRKELLTVYSSE-DGSEEFETIVLKALVKACGSSEASAYLDEL 397
Query: 413 NLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTI 472
LA+AW+RVDIA+ + + W+ LE ++ DAL+ DR +FV+LLI +G++L FLT
Sbjct: 398 RLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTP 457
Query: 473 PRLEELYNTKQGPTNTLLHHLVQD------VKQHTLLSG-YRITLIDIGLVVEYLIGRAY 525
RL +LY+ P+N+L+ +L+ K L G + D+G V+ L+G+
Sbjct: 458 MRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMC 515
Query: 526 RSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHK 585
Y H ES Y +K+
Sbjct: 516 APRYPSGG------------AWDPHPGQGFGESM--------------YLLSDKA----- 544
Query: 586 SRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILY 645
+ S + + P S DLL+WA+L+ R +MAM+FW+ G A A+ AC+L
Sbjct: 545 TSPLSLDAGLGQAPWS--------DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLL 596
Query: 646 RAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNS 705
R MA ++ + + K+ + +F + +DL + ++ +E A LL W ++
Sbjct: 597 RVMARLEPDA----EEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDA 652
Query: 706 TCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--LEFK 763
TCL+LA+ R F + Q LLT W G + W ++++ PP I T + F+
Sbjct: 653 TCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIW-ALVLAFFCPPLIYTRLITFR 711
Query: 764 SKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQ 823
K+E + +F + + + + A + R + G G +
Sbjct: 712 -KSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPR---QSGRPGCCGGRCGGRR 767
Query: 824 HLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQP-QPSVQEWLVSIYIFTN 882
L R+ + F+ AP+ F ++YL FL+LF+ +LV+ QP P E L+ + FT
Sbjct: 768 CL---RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTL 824
Query: 883 AIEVVRE--------ICISEPG----KFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWG 930
E +R+ + PG +Q++++++++ WN + VA+ F G R
Sbjct: 825 LCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL- 883
Query: 931 DPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLS 990
P + GR + CID + + RLL F VN+ GP + +++KM ++F+ + + + L++
Sbjct: 884 TPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVA 943
Query: 991 FGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV-------CSSQP---SCP 1040
+GVA + +L P++ S+ R + + PY I+G++ ++DV CSS+P + P
Sbjct: 944 YGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHP 1003
Query: 1041 PG-----------SFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRY 1089
PG ++L L ++L V I++VNLLIA F+ + ++ S+ WK RY
Sbjct: 1004 PGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRY 1063
Query: 1090 RYIMTYHEKPWLPPPLILLSHVGLLLRRLCCH-RAPHDQEEGDVGLKLYLSKEDLKKLHD 1148
R I +H +P L PP I++SH+ LLLR+LC R+P ++YLSKE +KL
Sbjct: 1064 RLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLT 1123
Query: 1149 FEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNE 1192
+E E + + D S ER++ TS++V QL + E
Sbjct: 1124 WESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIRE 1167
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 459 bits (1180), Expect = e-128
Identities = 361/1269 (28%), Positives = 585/1269 (46%), Gaps = 176/1269 (13%)
Query: 8 ERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYS 67
++ +S SWI K+EC + SSK VCQ CG H
Sbjct: 54 DKQESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQ---------CGYTHEQHLE---- 100
Query: 68 WTISAAKGK--ESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLH 125
A K + QW +KH + PTD FG I F G KY+R S DT + H
Sbjct: 101 ---EATKPHTFQGTQWDPKKHVQEMPTDAFGDIVFT-GLSQKVKKYVRVSQDTPSSVIYH 156
Query: 126 LMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSK 185
LM + W +++P L+ISV GG +NF M + K IF +GLVK A+TTGAWIIT G +TGV K
Sbjct: 157 LMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMK 216
Query: 186 HVGDALKS---HSSHSLRKIWTVGIPPWGVIENQRDLIGK--DVVCLYQTLDNPLSKLTT 240
VG+A++ SS+ ++ T+G+ WG + + LI Y ++ LT
Sbjct: 217 QVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC 276
Query: 241 LNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGV----PVVGLVVEGG 296
L+S HSHFIL DDGT G+YG E+ LR LEK++S Q + R GV P+V +V+EGG
Sbjct: 277 LDSNHSHFILVDDGTHGQYGVEIPLRTRLEKFISEQ---TKERGGVAIKIPIVCVVLEGG 333
Query: 297 PNVILSVWETVKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTF- 355
P + ++ + P VV EG+GR AD++A +L + +++++ Q F
Sbjct: 334 PGTLHTIDNATTNGTPCVVVEGSGRVADVIAQV-ANLPVSDITISLIQQKLSVFFQEMFE 392
Query: 356 NFSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGT-------NLSA 408
F+ + + + + + R +T+F + QQD+D+AIL ALLK + + +
Sbjct: 393 TFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENW 452
Query: 409 SEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHR 468
QL LA+AW+RVDIA+ I + E WKP L M+ AL+ ++ +FVKL +E GV L
Sbjct: 453 DHQLKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKE 512
Query: 469 FLTIPRLEELYNTKQGPTNTLLHHLVQDV------KQHTLLSGYRITLIDIGLVVEYLIG 522
F+T L LY + L H +Q V + + R+ + + V+ L+G
Sbjct: 513 FVTWDTLLYLYENLD--PSCLFHSKLQKVLVEDPERPACAPAAPRLQMHHVAQVLRELLG 570
Query: 523 RAYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIV 582
++T+ Y RH+ R + K + +
Sbjct: 571 -----DFTQP-----------LYPRPRHNDRLR-----------LLLPVPHVKLNVQGVS 603
Query: 583 LHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIAC 642
L K+S T + P DLL+WA++ R+++A W ++ A+
Sbjct: 604 LRSLYKRS-------SGHVTFTMDPIRDLLIWAIVQNRRELAGIIWAQSQDCIAAALACS 656
Query: 643 ILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNW 702
+ + ++ E +++ D+SEE+ ++++ A+ + + ++++E A LLT W
Sbjct: 657 KILKELSKEEEDT----DSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLTRVSEAW 712
Query: 703 SNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--L 760
+TCL+LA+ FVSH Q LT +W G+L + W ++ + ++ P +LT +
Sbjct: 713 GKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLW-RVTLCMLAFPLLLTGLI 771
Query: 761 EFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLES 820
F+ K Q G +
Sbjct: 772 SFREK----------------------------------------------RLQDVGTPA 785
Query: 821 GHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIF 880
+T V F+ + F F L LF Y ++V+ QP PS E + +++F
Sbjct: 786 ARARAFFTAPVVVFHLNILSYFAF--------LCLFAYVLMVDFQPVPSWCECAIYLWLF 837
Query: 881 TNAIEVVREICISEPGK--FTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAG 938
+ E +R++ +P + +K ++ S++WN + AI LF AG R P G
Sbjct: 838 SLVCEEMRQL-FYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL-IPATLYPG 895
Query: 939 RLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAI 998
R+I +D I + RL+ F +++ GP + ++ +M ++F+ + ++A+ ++SFGVA++AI
Sbjct: 896 RVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAI 955
Query: 999 LSPKEPPSWSLARDIVFEPYWMIYGEVYAGEID-------VCSS------QPSCPPG--- 1042
L E L R V+ Y I+G++ G ID CS +P CP
Sbjct: 956 LIHNERRVDWLFRGAVYHSYLTIFGQI-PGYIDGVNFNPEHCSPNGTDPYKPKCPESDAT 1014
Query: 1043 -------SFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTY 1095
+LT L +YL I+++NLLIA FN + ++ ++ +WK+ R+ I Y
Sbjct: 1015 QQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEY 1074
Query: 1096 HEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVE 1155
H +P PPP ILLSH+ L ++R+ ++ LK L K + L +E E
Sbjct: 1075 HGRPAAPPPFILLSHLQLFIKRVVLKTPAKRHKQ----LKNKLEKNEEAALLSWEIYLKE 1130
Query: 1156 KYFHEKMEDVNCSCEERIRVTSERVTEMYFQLK-EMNEKVSFIKDSLLSLDSQVGHLQDL 1214
Y + E++I S +V M L + ++ ++ L SL+ QV
Sbjct: 1131 NYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARA 1190
Query: 1215 SALTVDTLK 1223
V TL+
Sbjct: 1191 LHWIVRTLR 1199
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 427 bits (1099), Expect = e-119
Identities = 336/1164 (28%), Positives = 556/1164 (47%), Gaps = 103/1164 (8%)
Query: 96 GTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKF 155
G +NF G K++R L L+L EW + P LV+S+ G Q F M S
Sbjct: 26 GEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWL 84
Query: 156 KEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHSLR---KIWTVGIPPWGV 212
+++ +GLVKAA++TGAWI+T + G+++HVG A++ HS S ++ VG+ G
Sbjct: 85 RDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGR 144
Query: 213 IENQRDL--IGKDVVCLYQTLDN-PLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNL 269
+ ++R L +D Y D L +L+S SHFIL + G GK +LR L
Sbjct: 145 VLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRL 204
Query: 270 EKYLSLQKIHCRSRQGV--PVVGLVVEGGPNVILSVWETVKDKDPVVVCEGTGRAADLLA 327
EK++S Q+ + PV+ L+V G PN + + V+ P ++ G+G AD+LA
Sbjct: 205 EKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLA 264
Query: 328 --FTHKHLADEGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIFDAD 385
HL + Q KE+ + +FS + ++L H+ +T++D +
Sbjct: 265 ALVNQPHLLVPKVAEKQFKEKF-----PSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFE 319
Query: 386 SEEQQDLDLAILTALLKGTNLSASE------QLNLAMAWDRVDIAKKHILIYEQHWKPDA 439
E ++LD IL AL+K + E +L LA+AWDRVDIAK I + WK
Sbjct: 320 QEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCD 379
Query: 440 LEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQ 499
LE+ M DALV ++ +FV+L ++ G ++ FLT RL+ELY + +LL L+Q ++
Sbjct: 380 LEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVS--RKSLLFDLLQRKQE 437
Query: 500 HTLLSGYRITLIDIGL--VVEYLIGR-AYRSNYTRKHFRALYNNLYRKYKHQRHSSGNRN 556
R+TL +G E G A+ + + + + R + +Q G+R
Sbjct: 438 EA-----RLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGF-YQDGRPGDRR 491
Query: 557 ESAESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAV 616
+ + P K L +KS+ P+ DL +WAV
Sbjct: 492 RAEKG-----------PAKRPTGQKWLLDLNQKSEN--------------PWRDLFLWAV 526
Query: 617 LMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLA 676
L R +MA +FW G+E A+ AC + + M+H E+ A+ E K + +LA
Sbjct: 527 LQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAAR-ATREAK-----YERLA 580
Query: 677 LDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGR 736
LDL + + +E A LL R WS +TCL LA + F +H Q LT +W G
Sbjct: 581 LDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGD 640
Query: 737 LKMRKNSWLKIIISIILPPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQNASSSKESAS 796
+ L+++ + + P + T + + S++ D S ++
Sbjct: 641 MAAG-TPILRLLGAFLCPALVYT---------NLITFSEEAPLRTGLEDLQDLDSLDTEK 690
Query: 797 VKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLF 856
Y L+ +E ++ + G + G + + + +F+ AP+ F + Y AFL LF
Sbjct: 691 SPLYGLQSRVEELVEAPRAQG-DRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLF 749
Query: 857 TYTVLVEMQPQP---SVQEWLVSIYIFTNAIEVVRE-ICISEPGKFTQKVKVWISEYWNL 912
TY +LV+ +P P S E + ++FT +E +R+ E +K +++ + WN
Sbjct: 750 TYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNK 809
Query: 913 TETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAK 972
+ VAI LF G R F AGR + +D + + RL+ FA+++ GP + ++ +
Sbjct: 810 CDMVAIFLFIVGVTCRMLPSAFE-AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVER 868
Query: 973 MTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV 1032
M ++F+ + +++ L+++GV +A+L P + + R +++ PY I+G++ EID
Sbjct: 869 MMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDE 928
Query: 1033 ----CSSQP-------SCPP--GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESI 1079
CS+ P SCP ++L L +L V ++++NLLIA F+ + ++
Sbjct: 929 ARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGN 988
Query: 1080 SNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLS 1139
++ WK+ RY I+ YHE+P L PP ILLSH+ L LRR+ A H +E + L L
Sbjct: 989 ADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLD 1048
Query: 1140 KEDLKKLHDFEEQCVEKYFHEKMEDVNCSCE-ERIRVTSERVTEMYFQLKEMNEKVSFIK 1198
++ + E ++ F KME E E +R T+ RV + L + E+ IK
Sbjct: 1049 QKVVT-----WETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIK 1103
Query: 1199 DSLLSLDSQVGHLQDLSALTVDTL 1222
L+SQ+ + L + D L
Sbjct: 1104 ----CLESQINYCSVLVSSVADVL 1123
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 313 bits (802), Expect = 1e-84
Identities = 151/229 (65%), Positives = 186/229 (81%), Gaps = 2/229 (0%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQGVPVVG 290
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R QGVPVV
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA 181
Query: 291 LVVEGGPNVILSVWETVKDKD--PVVVCEGTGRAADLLAFTHKHLADEG 337
L+VEGGPNVI V E ++D PVVVC+G+GRA+D+LAF HK+ + G
Sbjct: 182 LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGG 230
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 300 bits (768), Expect = 1e-80
Identities = 153/254 (60%), Positives = 188/254 (74%), Gaps = 27/254 (10%)
Query: 111 YIRTSYDTKLDHLLHLMLKEWKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETT 170
Y+R S+DTK D LLHLM KEW++ELPKL+ISVHGG+QNF + K K++F +GL+KAA TT
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 171 GAWIITEGINTGVSKHVGDALKSHSSHSLRKIWTVGIPPWGVIENQRDLIGKDVVCLYQT 230
GAWI T G+NTGV +HVGDALK H+S S KI T+GI PWG++ENQ DLIG+DVV YQT
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQT 121
Query: 231 LDNPLSKLTTLNSMHSHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCR--------S 282
+ NP+SKLT LNSMHSHFIL+D+GT GKYG E+KLRR LEK++SLQKI+ R S
Sbjct: 122 MSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDS 181
Query: 283 R-----------------QGVPVVGLVVEGGPNVILSVWETVKDKD--PVVVCEGTGRAA 323
R QGVPVV L+VEGGPNVI V E ++D PVVVC+G+GRA+
Sbjct: 182 RLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRAS 241
Query: 324 DLLAFTHKHLADEG 337
D+LAF HK+ + G
Sbjct: 242 DILAFGHKYSEEGG 255
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 216 bits (549), Expect = 2e-55
Identities = 150/499 (30%), Positives = 254/499 (50%), Gaps = 43/499 (8%)
Query: 15 SWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTISAAK 74
++I+ F KREC SK +N+ C CG H + +
Sbjct: 43 NFIQANFKKRECVFFTKDSK----------ATENV--CKCGYAQSQH--------MEGTQ 82
Query: 75 GKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKME 134
+SE+W+ +KHT + PTD FG I F+ KYIR S DT + L L+ + W ++
Sbjct: 83 INQSEKWNYKKHTKEFPTDAFGDIQFET--LGKKGKYIRLSCDTDAEILYELLTQHWHLK 140
Query: 135 LPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSH 194
P LVISV GG +NF + + ++IFS+ L+ A++ GAWI+T G + G+ K++G+ ++ +
Sbjct: 141 TPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDN 199
Query: 195 --SSHSLRKIWTVGIPPWGVIENQRDLIGKD-----VVCLYQTLDNPLSKLTTLNSMHSH 247
S S I +GI WG++ N+ LI + Y D L L++ H+H
Sbjct: 200 TISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTH 259
Query: 248 FILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQG-VPVVGLVVEGGPNVILSVWET 306
+L D+G G E KLR LEKY+S + I + G +P+V GG + ++ +
Sbjct: 260 LLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTS 319
Query: 307 VKDKDPVVVCEGTGRAADLLAFTHKHLADEGMLRPQVKEEIICMIQNTFN-FSLKQSKHL 365
+K+K P VV EG+G+ AD++A + ++ + VKE+++ + T + ++++
Sbjct: 320 IKNKIPCVVVEGSGQIADVIASLVE--VEDALTSSAVKEKLVRFLPRTVSRLPEEETESW 377
Query: 366 FQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSASE------QLNLAMAWD 419
+ L E + +T+ + + + AI AL K + S + QL L + W+
Sbjct: 378 IKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWN 437
Query: 420 RVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELY 479
++D+A I ++ W+ L++ M AL+ DR FV+L +E G+NL +FLT L EL+
Sbjct: 438 QLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELF 497
Query: 480 NTKQGPTNTLLHHLVQDVK 498
+ +TL++ +Q K
Sbjct: 498 SNH---FSTLVYRNLQIAK 513
Score = 185 bits (469), Expect = 4e-46
Identities = 140/620 (22%), Positives = 275/620 (44%), Gaps = 106/620 (17%)
Query: 606 YPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEEL 665
+P L +WA+L +++++ W+ T+ A+ A L + +A + + + SEEL
Sbjct: 559 HPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGE-SEEL 617
Query: 666 KNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCT 725
N ++ A++L + + +E +A LL Y W S CL+LAV + F++
Sbjct: 618 AN---EYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGV 674
Query: 726 QMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--LEFKSKAEMSHVPQSQDFQFMWYY 783
Q L+ W G + +W KII+ + + P + + F+ K P + + +WYY
Sbjct: 675 QNFLSKQWYGEISRDTKNW-KIILCLFIIPLVGCGFVSFRKK------PVDKHKKLLWYY 727
Query: 784 SDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQHLPWTRKVYEFYSAPIVKFW 843
F+++P V F
Sbjct: 728 ------------------------------------------------VAFFTSPFVVFS 739
Query: 844 FYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFTQKVK 903
+ + Y+AFL+LF Y +L++ P E ++ +F + VR+ ++ FT
Sbjct: 740 WNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFT---- 795
Query: 904 VWISEYWNLTETVAIGLFSAGFVLRWGDPPFHT--AGRLIYCIDIIFWFSRLLDFFAVNQ 961
+ WN+ +T+ + F AG V R + +GR+I+C+D I + RL+ F V++
Sbjct: 796 ----DLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSR 851
Query: 962 HAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIVFEPYWMI 1021
+ GP + M+ +M ++F+ + + A+ +++FGVAR+ IL E + R +++EPY +
Sbjct: 852 NLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAM 911
Query: 1022 YGEVYAGEIDVCS------------SQPSCPP---------GSFLTPFLQAVYLFVQYII 1060
+G+V ++D + S+P C ++T L +Y+ I+
Sbjct: 912 FGQV-PSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNIL 970
Query: 1061 MVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLR---R 1117
+VNLL+A F ++ ++ +WK+ RY + Y + +P P I+ ++ ++++ +
Sbjct: 971 LVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAYFYMVVKKCFK 1030
Query: 1118 LCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKY---FHEKMEDVNCSCEERIR 1174
CC +E ++ + K + + +E E Y + K D + R R
Sbjct: 1031 CCC-------KEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRHRFR 1083
Query: 1175 VTSERVTEMYFQLKEMNEKV 1194
++ ++ LKE+ K+
Sbjct: 1084 QLDTKLNDLKGLLKEIANKI 1103
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 84.0 bits (206), Expect = 1e-15
Identities = 92/434 (21%), Positives = 178/434 (41%), Gaps = 75/434 (17%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 185 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 244
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 245 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 297
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 298 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 357
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 358 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 414
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096
F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M+Y
Sbjct: 415 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 474
Query: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLYLSKEDLKKLH 1147
E+ P+ +P P L + + LC + E G +G + + ++L++ H
Sbjct: 475 EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRR---AADNLRRHH 531
Query: 1148 DFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSL 1204
++E V++Y + D T E +TE F KE+ + +S + +L L
Sbjct: 532 QYQEVMRNLVKRYVAAMIRDAK---------TEEGLTEENF--KELKQDISSFRFEVLGL 580
Query: 1205 --DSQVGHLQDLSA 1216
S++ +Q +A
Sbjct: 581 LRGSKLSTIQSANA 594
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 84.0 bits (206), Expect = 1e-15
Identities = 92/434 (21%), Positives = 178/434 (41%), Gaps = 75/434 (17%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096
F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M+Y
Sbjct: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 647
Query: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLYLSKEDLKKLH 1147
E+ P+ +P P L + + LC + E G +G + + ++L++ H
Sbjct: 648 EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRR---AADNLRRHH 704
Query: 1148 DFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSL 1204
++E V++Y + D T E +TE F KE+ + +S + +L L
Sbjct: 705 QYQEVMRNLVKRYVAAMIRDAK---------TEEGLTEENF--KELKQDISSFRFEVLGL 753
Query: 1205 --DSQVGHLQDLSA 1216
S++ +Q +A
Sbjct: 754 LRGSKLSTIQSANA 767
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 84.0 bits (206), Expect = 1e-15
Identities = 92/436 (21%), Positives = 179/436 (41%), Gaps = 74/436 (16%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096
F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M+Y
Sbjct: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 647
Query: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLY--LSKEDLKK 1145
E+ P+ +P P L + + LC + E G +G++ + ++L++
Sbjct: 648 EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRR 707
Query: 1146 LHDFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLL 1202
H ++E V++Y + D T E +TE F KE+ + +S + +L
Sbjct: 708 HHQYQEVMRNLVKRYVAAMIRDAK---------TEEGLTEENF--KELKQDISSFRFEVL 756
Query: 1203 SL--DSQVGHLQDLSA 1216
L S++ +Q +A
Sbjct: 757 GLLRGSKLSTIQSANA 772
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 84.0 bits (206), Expect = 1e-15
Identities = 92/434 (21%), Positives = 178/434 (41%), Gaps = 75/434 (17%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096
F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M+Y
Sbjct: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 647
Query: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLYLSKEDLKKLH 1147
E+ P+ +P P L + + LC + E G +G + + ++L++ H
Sbjct: 648 EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRR---AADNLRRHH 704
Query: 1148 DFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSL 1204
++E V++Y + D T E +TE F KE+ + +S + +L L
Sbjct: 705 QYQEVMRNLVKRYVAAMIRDAK---------TEEGLTEENF--KELKQDISSFRFEVLGL 753
Query: 1205 --DSQVGHLQDLSA 1216
S++ +Q +A
Sbjct: 754 LRGSKLSTIQSANA 767
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 78.6 bits (192), Expect = 6e-14
Identities = 85/404 (21%), Positives = 163/404 (40%), Gaps = 64/404 (15%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096
F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M+Y
Sbjct: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 647
Query: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLYLSKEDLKKLH 1147
E+ P+ +P P L + + LC + E G +G + + ++L++ H
Sbjct: 648 EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGRR---AADNLRRHH 704
Query: 1148 DFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLK 1188
++E V++Y + D EE R + E QL+
Sbjct: 705 QYQEVMRNLVKRYVAAMIRD--AKTEEVARQQAAGPLERNIQLE 746
>gi|148596992 heart alpha-kinase [Homo sapiens]
Length = 2170
Score = 76.3 bits (186), Expect = 3e-13
Identities = 67/248 (27%), Positives = 101/248 (40%), Gaps = 16/248 (6%)
Query: 1776 DGGLRKAMRVVSTWSEDDILKPGQVFIVK--SFLPEVVRTWHKIFQESTVLHLCLREIQQ 1833
+G RKA R + KPG ++K + + R ++ Q + L +Q
Sbjct: 1927 EGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQN 1986
Query: 1834 QRAAQKLIYTFNQVKPQTIPYTPRFLEVFLIYCHSAN-QWLTIEKYMTGEFRKYNNNNGD 1892
IY + P + +FLI+ N + T+E+ + GEF KY+ +G
Sbjct: 1987 TARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGK 2046
Query: 1893 EITPTNTLEEL---MLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEVKQSRGMVF 1949
EI E F HW Y+ T G LLV D+QGVG LTD + ++G
Sbjct: 2047 EINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGI----ATLAKGYKG 2102
Query: 1950 GPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERIN------STFGLEIKIESA 2003
N I F A H CN C+ L L L+ N+ ++ + T + IK
Sbjct: 2103 FKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGP 2162
Query: 2004 EEPPARET 2011
E P ++T
Sbjct: 2163 ETPGEKKT 2170
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 72.8 bits (177), Expect = 3e-12
Identities = 71/316 (22%), Positives = 129/316 (40%), Gaps = 51/316 (16%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTY-------TVLVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL + T L P P+V EW++ ++
Sbjct: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRW-------GDPP------ 933
++E+ G FT+ +I ++WNL + L+ A L+ G P
Sbjct: 419 IKEMW---DGGFTE----YIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
Query: 934 FHTA--GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
+H ++ I I RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
Query: 992 GVAR------------------KAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVC 1033
K I K+ ++S + + +W ++G + + V
Sbjct: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLL---NLYVT 588
Query: 1034 SSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIM 1093
+ + F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M
Sbjct: 589 NVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWM 648
Query: 1094 TY-HEKPWLPPPLILL 1108
+Y E LPPP ++
Sbjct: 649 SYFDEGGTLPPPFNII 664
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 71.2 bits (173), Expect = 9e-12
Identities = 63/298 (21%), Positives = 123/298 (41%), Gaps = 48/298 (16%)
Query: 834 FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886
F P +KF +T +YL FL L L P P++ EW++ ++
Sbjct: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
Query: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931
++++ + ++ +I ++WNL + V L+ A L+ W
Sbjct: 418 IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
Query: 932 PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
++ I IF RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
Query: 992 ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036
G+ K I K+ ++S + + +W I+G + + V + +
Sbjct: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
Query: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVY-LDMESISNNLWKYNRYRYIM 1093
F+ + Y + ++++N+LIA NN Y L ++NL ++++Y+ +M
Sbjct: 588 AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRAADNLRRHHQYQEVM 645
>gi|9558749 elongation factor-2 kinase [Homo sapiens]
Length = 725
Score = 68.2 bits (165), Expect = 8e-11
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 7/117 (5%)
Query: 1875 IEKYMTGEFRKYNNNNGDEITPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDP 1934
+E Y+ G++ KYN+N+G + + AFSH+T+E + +L+V+D+QGVG+ TD
Sbjct: 228 LEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTD- 284
Query: 1935 SVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHHCNSCCRKLKLPDLKRNDYSPERIN 1991
P++ G FG NLG + F H CN C + L + + +N
Sbjct: 285 ----PQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVN 337
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 57.8 bits (138), Expect = 1e-07
Identities = 46/219 (21%), Positives = 96/219 (43%), Gaps = 20/219 (9%)
Query: 931 DPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLS 990
DP + G +Y I ++ FSR+ N+ GP + + ++F ++I +V ++
Sbjct: 535 DPQIISEG--LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVA 592
Query: 991 FGVARKAILS----PKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLT 1046
F + + S K P+++ + +W I+G + + ++
Sbjct: 593 FMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYV- 651
Query: 1047 PFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTY-HEKPWLPPPL 1105
L VY ++++N+LIA NN Y ++E ++ WK+ R + ++Y E LP P
Sbjct: 652 --LYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPF 709
Query: 1106 ----------ILLSHVGLLLRRLCCHRAPHDQEEGDVGL 1134
L+ + + L +LC +A + + ++G+
Sbjct: 710 NLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGM 748
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 55.5 bits (132), Expect = 5e-07
Identities = 57/297 (19%), Positives = 123/297 (41%), Gaps = 25/297 (8%)
Query: 931 DPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLS 990
DP + G +Y I ++ FSR+ N+ GP + + ++F +++ +V +
Sbjct: 606 DPQIISEG--LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFA 663
Query: 991 FGVARKAI----LSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLT 1046
F + + L K +++ + +W I+G + + ++
Sbjct: 664 FMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYV- 722
Query: 1047 PFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEK-PWLPPPL 1105
L +Y ++++N+LIA N+ Y ++E S+ WK+ R + ++Y + LPPP
Sbjct: 723 --LYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPF 780
Query: 1106 ILL----SHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKY---- 1157
L+ S V ++R + + + + D+ + + SK L + E +
Sbjct: 781 SLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNS 840
Query: 1158 -------FHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQ 1207
+ + M+ + + +V E +LKE+ + +S ++ LL SQ
Sbjct: 841 ILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQ 897
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 55.5 bits (132), Expect = 5e-07
Identities = 57/297 (19%), Positives = 123/297 (41%), Gaps = 25/297 (8%)
Query: 931 DPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLS 990
DP + G +Y I ++ FSR+ N+ GP + + ++F +++ +V +
Sbjct: 533 DPQIISEG--LYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFA 590
Query: 991 FGVARKAI----LSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQPSCPPGSFLT 1046
F + + L K +++ + +W I+G + + ++
Sbjct: 591 FMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYV- 649
Query: 1047 PFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEK-PWLPPPL 1105
L +Y ++++N+LIA N+ Y ++E S+ WK+ R + ++Y + LPPP
Sbjct: 650 --LYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPF 707
Query: 1106 ILL----SHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKKLHDFEEQCVEKY---- 1157
L+ S V ++R + + + + D+ + + SK L + E +
Sbjct: 708 SLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNS 767
Query: 1158 -------FHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLLSLDSQ 1207
+ + M+ + + +V E +LKE+ + +S ++ LL SQ
Sbjct: 768 ILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQ 824
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 54.3 bits (129), Expect = 1e-06
Identities = 49/259 (18%), Positives = 103/259 (39%), Gaps = 53/259 (20%)
Query: 898 FTQKVKVWISEYWNLTETVAIGLFSAGFVLRW---------------------------- 929
+TQ K ++ E WN+ + + +F+A F+ R+
Sbjct: 514 WTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLG 573
Query: 930 ---------------GDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMT 974
DP + G +Y I ++ FSR+ N+ GP + +
Sbjct: 574 DNVKYYNLARIKWDPSDPQIISEG--LYAIAVVLSFSRIAYILPANESFGPLQISLGRTV 631
Query: 975 ANMFYIVIIMAIVLLSFGVARKAILS----PKEPPSWSLARDIVFEPYWMIYGEVYAGEI 1030
++F ++I +V ++F + + S K+ +++ + +W I+G +
Sbjct: 632 KDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSV 691
Query: 1031 DVCSSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYR 1090
+ + ++ L VY I+++N+LIA N+ + ++E ++ WK+ R +
Sbjct: 692 VINYNHKFIENIGYV---LYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAK 748
Query: 1091 YIMTYHEK-PWLPPPLILL 1108
+Y E+ LP P L+
Sbjct: 749 LWFSYFEEGRTLPVPFNLV 767
>gi|156151443 alpha-kinase 1 [Homo sapiens]
Length = 1244
Score = 53.9 bits (128), Expect = 2e-06
Identities = 52/177 (29%), Positives = 84/177 (47%), Gaps = 24/177 (13%)
Query: 1816 KIFQESTVLHLCLREIQQQRAAQKLIYTFNQ-VKPQTIP----YTPRFLEVFLIYCHSAN 1870
K ++E L ++++Q AQ + FN+ + Q IP Y P + + ++ +
Sbjct: 1067 KDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTI-LLILEDKTIK 1125
Query: 1871 QWLTIEKYMTGEFRKYNNNNGDEITPTN-TLEELMLAFSHWTYEYTRGELLVLDLQG-VG 1928
+++E Y+ GEF K +NN ++ T E LA+ H++YE++ +V+DLQG V
Sbjct: 1126 GCISVEPYILGEFVKLSNNT--KVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVT 1183
Query: 1929 EN------LTDPSVIKPEVKQSRGMVFGPANLGEDAIRNFIAKHH--CNSCCRKLKL 1977
N LTDP + + K VF N G+ I F H CN C +L L
Sbjct: 1184 GNGKGLIYLTDPQIHSVDQK-----VF-TTNFGKRGIFYFFNNQHVECNEICHRLSL 1234
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,445,669
Number of Sequences: 37866
Number of extensions: 3526406
Number of successful extensions: 10045
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 9655
Number of HSP's gapped (non-prelim): 290
length of query: 2022
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1905
effective length of database: 13,817,196
effective search space: 26321758380
effective search space used: 26321758380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.