Search of human proteins with 18860833

Search of human proteins with 18860833

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
         (942 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]                 1883   0.0  
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]                1865   0.0  
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]                 1865   0.0  
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]                1847   0.0  
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]                1840   0.0  
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]                 1840   0.0  
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]                1821   0.0  
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]                 1821   0.0  
gi|56549125 dynamin 2 isoform 4 [Homo sapiens]                        114   4e-25
gi|56549123 dynamin 2 isoform 2 [Homo sapiens]                        114   4e-25
gi|56549121 dynamin 2 isoform 1 [Homo sapiens]                        114   4e-25
gi|56549119 dynamin 2 isoform 3 [Homo sapiens]                        114   4e-25
gi|56549117 dynamin 1 isoform 2 [Homo sapiens]                        107   5e-23
gi|59853099 dynamin 1 isoform 1 [Homo sapiens]                        107   5e-23
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]                  104   3e-22
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]                  104   3e-22
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]                  104   3e-22
gi|42544243 dynamin 3 isoform a [Homo sapiens]                        103   8e-22
gi|209915561 dynamin 3 isoform b [Homo sapiens]                       103   8e-22
gi|222136619 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|222136617 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|11342664 myxovirus resistance protein 2 [Homo sapiens]              99   2e-20
gi|71061468 centromere protein E [Homo sapiens]                        39   0.017
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     39   0.017
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...    39   0.023
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...    39   0.023
gi|28173564 keratin 73 [Homo sapiens]                                  39   0.030
gi|148612803 keratin 6 irs4 [Homo sapiens]                             38   0.051
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    38   0.051
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    38   0.051

>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
          Length = 942

 Score = 1883 bits (4878), Expect = 0.0
 Identities = 942/942 (100%), Positives = 942/942 (100%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180

Query: 181 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 240
           GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR
Sbjct: 181 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 240

Query: 241 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 300
           KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS
Sbjct: 241 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 300

Query: 301 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 360
           GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS
Sbjct: 301 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 360

Query: 361 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 420
           PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD
Sbjct: 361 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 420

Query: 421 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 480
           GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY
Sbjct: 421 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 480

Query: 481 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE
Sbjct: 481 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540

Query: 541 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 600
           SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE
Sbjct: 541 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 600

Query: 601 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660
           ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ
Sbjct: 601 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660

Query: 661 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 720
           EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK
Sbjct: 661 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 720

Query: 721 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 780
           QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM
Sbjct: 721 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 780

Query: 781 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 840
           LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR
Sbjct: 781 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 840

Query: 841 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 900
           GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA
Sbjct: 841 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 900

Query: 901 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942
           EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 901 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942


>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
          Length = 978

 Score = 1865 bits (4831), Expect = 0.0
 Identities = 942/978 (96%), Positives = 942/978 (96%), Gaps = 36/978 (3%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 150 -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 204
                GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240

Query: 205 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 264
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300

Query: 265 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 324
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360

Query: 325 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 384
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420

Query: 385 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 444
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480

Query: 445 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 504
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540

Query: 505 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 564
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600

Query: 565 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 624
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660

Query: 625 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 684
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720

Query: 685 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 744
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780

Query: 745 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 804
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840

Query: 805 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 864
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900

Query: 865 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 924
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960

Query: 925 REIQEKLDAFIEALHQEK 942
           REIQEKLDAFIEALHQEK
Sbjct: 961 REIQEKLDAFIEALHQEK 978


>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
          Length = 979

 Score = 1865 bits (4830), Expect = 0.0
 Identities = 942/979 (96%), Positives = 942/979 (96%), Gaps = 37/979 (3%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180

Query: 181 GSESDKHF-------------------------------------RKVSDKEKIDQLQEE 203
           GSESDKHF                                     RKVSDKEKIDQLQEE
Sbjct: 181 GSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEE 240

Query: 204 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 263
           LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS
Sbjct: 241 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 300

Query: 264 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 323
           YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF
Sbjct: 301 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 360

Query: 324 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 383
           KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG
Sbjct: 361 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 420

Query: 384 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 443
           VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR
Sbjct: 421 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 480

Query: 444 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 503
           TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE
Sbjct: 481 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 540

Query: 504 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 563
           FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN
Sbjct: 541 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 600

Query: 564 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 623
           YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA
Sbjct: 601 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 660

Query: 624 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 683
           QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK
Sbjct: 661 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 720

Query: 684 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 743
           EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN
Sbjct: 721 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 780

Query: 744 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 803
           AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL
Sbjct: 781 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 840

Query: 804 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 863
           ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW
Sbjct: 841 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 900

Query: 864 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 923
           RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK
Sbjct: 901 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 960

Query: 924 VREIQEKLDAFIEALHQEK 942
           VREIQEKLDAFIEALHQEK
Sbjct: 961 VREIQEKLDAFIEALHQEK 979


>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
          Length = 1015

 Score = 1847 bits (4783), Expect = 0.0
 Identities = 942/1015 (92%), Positives = 942/1015 (92%), Gaps = 73/1015 (7%)

Query: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
            MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
            QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
            QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 150  -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF---------------- 188
                 GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF                
Sbjct: 181  DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240

Query: 189  ---------------------RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 227
                                 RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 241  EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300

Query: 228  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 287
            LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 301  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360

Query: 288  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 347
            EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 361  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420

Query: 348  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 407
            RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 421  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480

Query: 408  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 467
            MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 481  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540

Query: 468  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 527
            IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 541  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600

Query: 528  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 587
            LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 601  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660

Query: 588  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 647
            ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 661  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720

Query: 648  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 707
            PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 721  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780

Query: 708  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 767
            QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 781  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840

Query: 768  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 827
            CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 841  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900

Query: 828  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 887
            LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 901  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960

Query: 888  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942
            LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 961  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015


>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
          Length = 960

 Score = 1840 bits (4766), Expect = 0.0
 Identities = 928/961 (96%), Positives = 932/961 (96%), Gaps = 20/961 (2%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLL------------- 167
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF  K+   +  + DL+ L              
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF-EKIRKALPSSEDLVKLAPDFDKIVESLSLL 179

Query: 168 ------GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKE 221
                 GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKE
Sbjct: 180 KDFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKE 239

Query: 222 NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA 281
           NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA
Sbjct: 240 NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA 299

Query: 282 GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL 341
           GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL
Sbjct: 300 GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL 359

Query: 342 RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF 401
           RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF
Sbjct: 360 RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF 419

Query: 402 SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP 461
           SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP
Sbjct: 420 SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP 479

Query: 462 SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV 521
           SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV
Sbjct: 480 SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV 539

Query: 522 TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN 581
           TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN
Sbjct: 540 TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN 599

Query: 582 EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ 641
           EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ
Sbjct: 600 EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ 659

Query: 642 WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 701
           WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE
Sbjct: 660 WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 719

Query: 702 DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK 761
           DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK
Sbjct: 720 DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK 779

Query: 762 NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 821
           NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ
Sbjct: 780 NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 839

Query: 822 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 881
           VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT
Sbjct: 840 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 899

Query: 882 NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE 941
           NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE
Sbjct: 900 NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE 959

Query: 942 K 942
           K
Sbjct: 960 K 960


>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
          Length = 924

 Score = 1840 bits (4765), Expect = 0.0
 Identities = 924/942 (98%), Positives = 924/942 (98%), Gaps = 18/942 (1%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG                  SPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG------------------SPEETAFRATDR 162

Query: 181 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 240
           GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR
Sbjct: 163 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 222

Query: 241 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 300
           KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS
Sbjct: 223 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 282

Query: 301 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 360
           GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS
Sbjct: 283 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 342

Query: 361 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 420
           PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD
Sbjct: 343 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 402

Query: 421 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 480
           GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY
Sbjct: 403 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 462

Query: 481 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE
Sbjct: 463 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522

Query: 541 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 600
           SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE
Sbjct: 523 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 582

Query: 601 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660
           ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ
Sbjct: 583 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 642

Query: 661 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 720
           EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK
Sbjct: 643 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 702

Query: 721 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 780
           QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM
Sbjct: 703 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 762

Query: 781 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 840
           LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR
Sbjct: 763 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 822

Query: 841 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 900
           GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA
Sbjct: 823 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 882

Query: 901 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942
           EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 883 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924


>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
          Length = 997

 Score = 1821 bits (4718), Expect = 0.0
 Identities = 928/998 (92%), Positives = 932/998 (93%), Gaps = 57/998 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLL------------- 167
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF  K+   +  + DL+ L              
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF-EKIRKALPSSEDLVKLAPDFDKIVESLSLL 179

Query: 168 ------GSPEETAFRATDRGSESDKHF--------------------------------- 188
                 GSPEETAFRATDRGSESDKHF                                 
Sbjct: 180 KDFFTSGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSY 239

Query: 189 ----RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKK 244
               RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKK
Sbjct: 240 AQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKK 299

Query: 245 SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM 304
           SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM
Sbjct: 300 SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM 359

Query: 305 TRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETI 364
           TRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETI
Sbjct: 360 TRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETI 419

Query: 365 SLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVD 424
           SLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVD
Sbjct: 420 SLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVD 479

Query: 425 AERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVV 484
           AERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVV
Sbjct: 480 AERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVV 539

Query: 485 TGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQ 544
           TGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQ
Sbjct: 540 TGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQ 599

Query: 545 QADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQ 604
           QADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQ
Sbjct: 600 QADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQ 659

Query: 605 SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFS 664
           SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFS
Sbjct: 660 SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFS 719

Query: 665 RFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWD 724
           RFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWD
Sbjct: 720 RFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWD 779

Query: 725 AAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCN 784
           AAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCN
Sbjct: 780 AAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCN 839

Query: 785 EEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYY 844
           EEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYY
Sbjct: 840 EEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYY 899

Query: 845 YQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGE 904
           YQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGE
Sbjct: 900 YQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGE 959

Query: 905 KKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942
           KKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 960 KKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 997


>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
          Length = 961

 Score = 1821 bits (4717), Expect = 0.0
 Identities = 924/979 (94%), Positives = 924/979 (94%), Gaps = 55/979 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG                  SPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG------------------SPEETAFRATDR 162

Query: 181 GSESDKHFRK-------------------------------------VSDKEKIDQLQEE 203
           GSESDKHFRK                                     VSDKEKIDQLQEE
Sbjct: 163 GSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEE 222

Query: 204 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 263
           LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS
Sbjct: 223 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 282

Query: 264 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 323
           YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF
Sbjct: 283 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 342

Query: 324 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 383
           KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG
Sbjct: 343 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 402

Query: 384 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 443
           VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR
Sbjct: 403 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 462

Query: 444 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 503
           TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE
Sbjct: 463 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 522

Query: 504 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 563
           FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN
Sbjct: 523 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 582

Query: 564 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 623
           YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA
Sbjct: 583 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 642

Query: 624 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 683
           QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK
Sbjct: 643 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 702

Query: 684 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 743
           EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN
Sbjct: 703 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 762

Query: 744 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 803
           AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL
Sbjct: 763 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 822

Query: 804 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 863
           ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW
Sbjct: 823 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 882

Query: 864 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 923
           RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK
Sbjct: 883 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 942

Query: 924 VREIQEKLDAFIEALHQEK 942
           VREIQEKLDAFIEALHQEK
Sbjct: 943 VREIQEKLDAFIEALHQEK 961


>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 541 SVEQQADSFKATRFNLE---TEWKNNYP 565
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 541 SVEQQADSFKATRFNLE---TEWKNNYP 565
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 541 SVEQQADSFKATRFNLE---TEWKNNYP 565
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 541 SVEQQADSFKATRFNLE---TEWKNNYP 565
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
          Length = 851

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKG---NSSESIEAIREYEEEFF 505
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
          Length = 864

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 484 VTGKG---NSSESIEAIREYEEEFF 505
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
          Length = 736

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 304 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 347
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 348 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 407
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 408 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 467
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 468 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 506
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
          Length = 699

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 304 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 347
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 348 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 407
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 408 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 467
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 468 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 506
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
          Length = 710

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 304 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 347
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 348 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 407
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 408 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 467
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 468 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 506
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|42544243 dynamin 3 isoform a [Homo sapiens]
          Length = 863

 Score =  103 bits (257), Expect = 8e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 484 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 541 SVEQQADSFKATRFNLETE---WKNNYP 565
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|209915561 dynamin 3 isoform b [Homo sapiens]
          Length = 859

 Score =  103 bits (257), Expect = 8e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 244 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 303
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 304 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 363
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 364 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 423
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 424 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 484 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 541 SVEQQADSFKATRFNLETE---WKNNYP 565
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 229 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 287
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 288 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 346
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 347 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 406
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 407 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 466
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 467 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 522
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 523 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 578
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 579 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 634
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 635 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 692
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 229 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 287
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 288 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 346
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 347 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 406
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 407 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 466
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 467 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 522
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 523 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 578
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 579 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 634
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 635 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 692
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
          Length = 715

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)

Query: 270 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 329
           LP + V+GDQS+GK+SVLE ++   + PRGSG ++TR P+ + L + P      + S R 
Sbjct: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175

Query: 330 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 389
            +L + +D   +  EI          G  +S E ISL +  P +  + ++DLPG+     
Sbjct: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234

Query: 390 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 449
                D    I ++ K Y+Q    I L +   +VD   +    +  ++DP G RTI +LT
Sbjct: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294

Query: 450 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
           K DL ++   +   +  ++    +P+K  GY  V
Sbjct: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 39.3 bits (90), Expect = 0.017
 Identities = 166/886 (18%), Positives = 343/886 (38%), Gaps = 138/886 (15%)

Query: 123  KDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDRGS 182
            KD++ +L E +  + D+  E+++ ++    L  EVI  S+L  L    E       D+  
Sbjct: 710  KDLLCNL-ELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSE 768

Query: 183  ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKL 242
            E       +   EK D+L  E++H + + Q +LE + K           KDD        
Sbjct: 769  ELH-----IITSEK-DKLFSEVVHKESRVQGLLEEIGK----------TKDDLATTQSNY 812

Query: 243  KKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGE 302
             KS    +     +  D++  Y         +V+ +       ++ +  +A+ F    G 
Sbjct: 813  -KSTDQEFQNFKTLHMDFEQKYK--------MVLEENERMNQEIVNLSKEAQKFDSSLGA 863

Query: 303  MMTRSPVKV-TLSEGPHHVALFKDSSREFDLTKEE------DLAALRHE---IELRMRKN 352
            + T    K   L E    V   ++   E +  KE+       L  +  E   I  ++++ 
Sbjct: 864  LKTELSYKTQELQEKTREV---QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920

Query: 353  VKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTV--TSGMAPDTKETIFSISKAYMQN 410
            ++E  T++ E   L      LQ  + ++   + + +  T  M  DT+E + +  ++  Q+
Sbjct: 921  LEEVKTLTQEKDDLK----QLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976

Query: 411  PNAIILCIQDGSVDAERSI--VTDLVSQMDPHGRRTIFVLTKVDLAEKN---VASPSRIQ 465
               I       S +  R++    +     D   ++ + +  K DL  KN   + +  +  
Sbjct: 977  QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036

Query: 466  QIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRN 525
            +IIE      +    F+++  K    + +E++   +E+       LKT + +  ++T  N
Sbjct: 1037 EIIE------QQRKIFSLIQEKNELQQMLESVIAEKEQ-------LKTDLKENIEMTIEN 1083

Query: 526  L-SLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLREL-----DRNELFEKA 579
               L +     K  +E V Q+    K      E E      RL E+     ++++  ++ 
Sbjct: 1084 QEELRLLGDELKKQQEIVAQE----KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139

Query: 580  KNEILDEVISLSQVTPK--HWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDI 637
            + ++L+    +S++  K    E +  +   + ++   +E   L  AQ +N          
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENY------E 1193

Query: 638  KLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKG----------------KEHDDIFDK 681
            ++K  T ++   K ++ ++ET ++    ++ E +                 KEH +  D+
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253

Query: 682  LKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDT 741
            L+ +V E+             + ++I    LE      K Q +  +   E+ L   +K+ 
Sbjct: 1254 LRRSVSEK-------------TAQIINTQDLE--KSHTKLQEEIPVLHEEQELLPNVKEV 1298

Query: 742  ENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLAS-DEITTVR 800
                E M   +        K+ T    +  E     EK  +  EE  +     D + T++
Sbjct: 1299 SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIK 1358

Query: 801  KNLESRGVE----VDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSEL-- 854
            + LE +  +    +  +L K    Q  +   L          +      Q    DS L  
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418

Query: 855  -ECNDVVLFWRIQ------RMLAITANTLR--QQLTNTEVRRLEKNVKEVLEDFAEDGE- 904
             E   + L  R+Q      + +A   + L+  Q++  +E  +L++N+KE++    E  E 
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 905  ---------KKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE 941
                     ++ + +   RV L+E   ++  IQ++L+A  + L  +
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 147/796 (18%), Positives = 315/796 (39%), Gaps = 100/796 (12%)

Query: 199  QLQEEL--LHTQLK-YQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLD 255
            Q +EEL   H  LK +Q  ++ L +   E    ++   D    H KL++ +  ++ E  +
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ-E 1290

Query: 256  VLSDYDASYNTQDHLPRVVVVGDQSAGKTSV------LEMIAQARIFPRGSGEMMTRSPV 309
            +L +      TQ+ +  + ++ +QS  K S       +E +     F     E+ + +  
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350

Query: 310  KVTLSEGPHHVALFKDSSREF---DLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISL 366
            +  L      + +  D  +E     L K ++  + + E  L M++   E   +  E    
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS-KQEQSLNMKEKDNETTKIVSEMEQF 1409

Query: 367  NVKGPGLQRMVLVDLPGV-----------------------INTVTSGMAPDTKETIFSI 403
              K   L R + +++ G+                       +  V    +   KE I  I
Sbjct: 1410 KPKDSALLR-IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468

Query: 404  SKAYMQNPNAIIL---CIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVAS 460
               +++    + +   C+++     +   + +L  +++   + T     +  L   N   
Sbjct: 1469 VAKHLETEEELKVAHCCLKE-----QEETINEL--RVNLSEKETEISTIQKQLEAINDKL 1521

Query: 461  PSRIQQIIEGK-LFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAH 519
             ++IQ+I E +  F +K +   + V  K N  +  +  R+ ++   Q+ +     +    
Sbjct: 1522 QNKIQEIYEKEEQFNIKQI---SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578

Query: 520  QVTTRNLSLAVSDCF-WKMVRESVEQQADSFKATRFNLETEWKNN----YPRLRELDRNE 574
            Q +   + + + +    K V+E+++ + D  K     +  + K +    Y  L+    NE
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638

Query: 575  LFEK-AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNT 633
              EK  + E L E     ++   + E I  +++  R++  + EN+    + T       +
Sbjct: 1639 TQEKMCEIEHLKEQFETQKL---NLENIETENI--RLTQILHENLEEMRSVTKERDDLRS 1693

Query: 634  TVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKR 693
             V+  LK   D QL     E     L+++    +     KEH +  DKL+  V E++ + 
Sbjct: 1694 -VEETLKVERD-QLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEI 1751

Query: 694  HKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDW 753
                   E S     ++AL+ + +  +++   A           LK+ +  I+ + G   
Sbjct: 1752 SNMQKDLEHS-----NDALKAQDLKIQEELRIA--------HMHLKEQQETIDKLRGIVS 1798

Query: 754  KKRWLYWKNRTQEQCVHNETKNELEKM--LKCNEEHPAYLASDEITTVRKNLESRGVEVD 811
            +K     K    ++ + N      EK+  LK NE     L  D   T +K  E   +E  
Sbjct: 1799 EKT---DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSE---MEQL 1852

Query: 812  PSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAI 871
               IKD           K  + + NL ++   +     + S ++  D +   R++  L +
Sbjct: 1853 KKQIKD-----QSLTLSKLEIENLNLAQK--LHENLEEMKSVMKERDNLR--RVEETLKL 1903

Query: 872  TANTLRQQLTNTEVRRLE-----KNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVRE 926
              + L++ L  T+ R LE     K  + + ++  E  +K  + ++ K +Q+++  K + +
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963

Query: 927  IQEKLDAFIEALHQEK 942
             +++L   I+ L +++
Sbjct: 1964 SKDELQKKIQELQKKE 1979


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 39.3 bits (90), Expect = 0.017
 Identities = 145/792 (18%), Positives = 311/792 (39%), Gaps = 129/792 (16%)

Query: 193  DKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSL---IDM 249
            DK K+ +L  +L  T  ++Q +    EK NK L       +DK +  +KL + L   +D+
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-------EDKSLEFKKLSEELAIQLDI 1219

Query: 250  YSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 309
              +  + L +   +        +   +  + +        + +A +    +   +     
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279

Query: 310  KVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVK 369
            ++T  +   +++ F+ ++ + +  KE  + +++ +IE           ++  E  +L  +
Sbjct: 1280 QLTEEQNTLNIS-FQQATHQLE-EKENQIKSMKADIE-----------SLVTEKEALQKE 1326

Query: 370  GPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSI 429
            G   Q+                 A + +  I  + K   +N NA+ L  ++  +  ++  
Sbjct: 1327 GGNQQQA----------------ASEKESCITQLKKELSENINAVTLMKEE--LKEKKVE 1368

Query: 430  VTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGK---LFPMKALGYFAVVTG 486
            ++ L  Q+       + +   + L+EK  A  S  +Q  E K   L  ++ L  F V T 
Sbjct: 1369 ISSLSKQLTD---LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVDTL 1424

Query: 487  KGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVS---------DCFWKM 537
                  ++E + ++  +F +  K  + S    HQ T + L + +          D    +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQ-SRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 538  VRESVEQQADSFKATR--------------FNLETEWKNNYPRLRELDRNELFEKAKNEI 583
            ++E ++QQ   F   +               NLETE K+   R+ EL+ +   +  + E 
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543

Query: 584  LDEVI-SLSQVTPKHWEEILQ-----QSLWERVSTHVIE----------NIYLPAAQTMN 627
            L+EV+ + +Q      +E++Q     Q L E     V E           +Y   A+   
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603

Query: 628  SGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVK 687
                   V++ +K    K+   KA+E   + L+ E +  + E K K    I    K+ + 
Sbjct: 1604 KKKELEHVNLSVK---SKEEELKALE---DRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 688  EESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA-IE 746
            +   K  ++    E  L  +          +  Q+ +  ++ +EE    +LK  E++  E
Sbjct: 1658 QMEEKEEQYKKGTESHLSELN---------TKLQEREREVHILEE----KLKSVESSQSE 1704

Query: 747  NMVGPDWKKRWLYWKNRTQ---EQCV---HNETKNELEKMLKCNEEHPAYLASDEITTVR 800
             ++ P   K    +  + +   + CV   + E  + L++ L   E+    +  ++  TV 
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764

Query: 801  KNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNH----CNLCRRGFYYYQRHFVDSELEC 856
             + E R  +    LIK   H   ++H  ++ + H         + +       V+ E   
Sbjct: 1765 SHFEMR-CQYQERLIK-LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822

Query: 857  NDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQ 916
            N++     ++ +      TL+++    ++  LE+ +KE+  D     +K++      RV+
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQI--LEQKIKEL--DSCLVRQKEV-----HRVE 1873

Query: 917  LAEDLKKVREIQ 928
            + E   K  ++Q
Sbjct: 1874 MEELTSKYEKLQ 1885



 Score = 37.0 bits (84), Expect = 0.087
 Identities = 125/656 (19%), Positives = 251/656 (38%), Gaps = 135/656 (20%)

Query: 183  ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK---LVLQKDDKGIHH 239
            ES KH +     EK+  L+++    Q + +++ E+ E+E + L K   ++ Q   + ++ 
Sbjct: 617  ESLKHQQDALWTEKLQVLKQQY---QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673

Query: 240  RKLKK------SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLE--MIA 291
            + L+K       L  + SE+ +VL    A +  ++ L    V+ DQ+      LE  M  
Sbjct: 674  KTLEKLDVKQTELESLSSELSEVLK---ARHKLEEELS---VLKDQTDKMKQELEAKMDE 727

Query: 292  QARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLT-KEEDLAALRHEIELR-M 349
            Q     +    ++    V +  +E        KD   + +L  KE D     H+  +  +
Sbjct: 728  QKNHHQQQVDSIIKEHEVSIQRTE-----KALKDQINQLELLLKERDKHLKEHQAHVENL 782

Query: 350  RKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQ 409
              ++K              +G   Q    +D+     + T       +E +  + +  + 
Sbjct: 783  EADIKRS------------EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830

Query: 410  -NPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSR-IQQI 467
                 I+L  Q   V+A++    D+ +++D H  +   ++ +++     +    + + Q+
Sbjct: 831  LETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887

Query: 468  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 527
             E KL             G     ++ + + E E    Q    ++    K  ++ T+ LS
Sbjct: 888  YESKL-----------EDGNKEQEQTKQILVEKENMILQ----MREGQKKEIEILTQKLS 932

Query: 528  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRN--ELFEKAKNEILD 585
                             + DS        ET++KN   ++ ++ +   E+ E  K ++LD
Sbjct: 933  A----------------KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD 976

Query: 586  EVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDK 645
            +   L +       E+ Q+   ++ +  ++E      AQ  ++G  +    +        
Sbjct: 977  QEAKLKKELENTALELSQKE--KQFNAKMLE-----MAQANSAGISDAVSRL-------- 1021

Query: 646  QLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLR 705
                       ET Q+E    +TE   +E +D+           SI   K N  AE+ L+
Sbjct: 1022 -----------ETNQKEQIESLTEVHRRELNDVI----------SIWEKKLNQQAEE-LQ 1059

Query: 706  VIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQ 765
             I    L+++     +     + F  E  +   + T               WL      +
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT---------------WL-----KE 1099

Query: 766  EQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 821
            E    + T NEL++ LK    H   LA DE T ++ +LE   V+++ SL ++T+ Q
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDE-TKLKAHLEKLEVDLNKSLKENTFLQ 1154


>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 38.9 bits (89), Expect = 0.023
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 494  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 553
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 554  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 613
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 614  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 662
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 663  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 715
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 716  SIS 718
             +S
Sbjct: 1388 EVS 1390


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 38.9 bits (89), Expect = 0.023
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 494  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 553
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 554  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 613
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 614  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 662
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 663  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 715
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 716  SIS 718
             +S
Sbjct: 1388 EVS 1390


>gi|28173564 keratin 73 [Homo sapiens]
          Length = 540

 Score = 38.5 bits (88), Expect = 0.030
 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 858 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 917
           D V F   Q  +  T   L QQL   ++   + N++ +LE +  +  K+++ L+G RV+L
Sbjct: 148 DKVRFLEQQNQVLETKWELLQQL---DLNNCKNNLEPILEGYISNLRKQLETLSGDRVRL 204

Query: 918 AEDLKKVREIQE 929
             +L+ VRE+ E
Sbjct: 205 DSELRSVREVVE 216


>gi|148612803 keratin 6 irs4 [Homo sapiens]
          Length = 529

 Score = 37.7 bits (86), Expect = 0.051
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 3/72 (4%)

Query: 858 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 917
           D V F   Q  +  T   L QQL   ++   +KN++ +LE +  +  K+++ L+G RV+L
Sbjct: 156 DKVRFLEQQNQVLETKWELLQQL---DLNNCKKNLEPILEGYISNLRKQLETLSGDRVRL 212

Query: 918 AEDLKKVREIQE 929
             +L+ +R++ E
Sbjct: 213 DSELRSMRDLVE 224


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 37.7 bits (86), Expect = 0.051
 Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)

Query: 550  KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 604
            K    NL  E KN+Y  L+    +E  +K+ + I+D++   L  VT K+ E+ L+     
Sbjct: 717  KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 773

Query: 605  ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660
                SL + VS   +E +++P  +         +  ++LK+    +L  K  E      Q
Sbjct: 774  LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 825

Query: 661  EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 704
            E+     +E               K H+++     D L +  +E    + K+ D  ++ +
Sbjct: 826  EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 885

Query: 705  RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 764
            ++   N +  R++ + Q    A Y      +A++     ++  +   + +    Y K + 
Sbjct: 886  KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 945

Query: 765  QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 821
            +   +H E K    EL+ + +C +   A + S E     +  ++   E+   L + T   
Sbjct: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1003

Query: 822  VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 881
                  +K      +  ++  +  Q+   D  +    +     ++R L+   + L +QL 
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1060

Query: 882  N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 919
            +     TEV+ +     E+N K+  E  A            E  E   K L G    L E
Sbjct: 1061 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1120

Query: 920  DLKKVREIQEKLDAFIEALHQ 940
            +LK ++   EK    +  LHQ
Sbjct: 1121 ELKSMQRCYEKEQQTVTKLHQ 1141


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 37.7 bits (86), Expect = 0.051
 Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)

Query: 550  KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 604
            K    NL  E KN+Y  L+    +E  +K+ + I+D++   L  VT K+ E+ L+     
Sbjct: 730  KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 786

Query: 605  ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660
                SL + VS   +E +++P  +         +  ++LK+    +L  K  E      Q
Sbjct: 787  LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 838

Query: 661  EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 704
            E+     +E               K H+++     D L +  +E    + K+ D  ++ +
Sbjct: 839  EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898

Query: 705  RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 764
            ++   N +  R++ + Q    A Y      +A++     ++  +   + +    Y K + 
Sbjct: 899  KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958

Query: 765  QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 821
            +   +H E K    EL+ + +C +   A + S E     +  ++   E+   L + T   
Sbjct: 959  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1016

Query: 822  VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 881
                  +K      +  ++  +  Q+   D  +    +     ++R L+   + L +QL 
Sbjct: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1073

Query: 882  N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 919
            +     TEV+ +     E+N K+  E  A            E  E   K L G    L E
Sbjct: 1074 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1133

Query: 920  DLKKVREIQEKLDAFIEALHQ 940
            +LK ++   EK    +  LHQ
Sbjct: 1134 ELKSMQRCYEKEQQTVTKLHQ 1154


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,790,859
Number of Sequences: 37866
Number of extensions: 1493783
Number of successful extensions: 6967
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 6663
Number of HSP's gapped (non-prelim): 408
length of query: 942
length of database: 18,247,518
effective HSP length: 112
effective length of query: 830
effective length of database: 14,006,526
effective search space: 11625416580
effective search space used: 11625416580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.