Search of human proteins with 18860831

Search of human proteins with 18860831

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
         (924 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]                 1851   0.0  
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]                 1840   0.0  
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]                1833   0.0  
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]                 1832   0.0  
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]                1821   0.0  
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]                 1821   0.0  
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]                1814   0.0  
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]                1803   0.0  
gi|56549125 dynamin 2 isoform 4 [Homo sapiens]                        114   4e-25
gi|56549123 dynamin 2 isoform 2 [Homo sapiens]                        114   4e-25
gi|56549121 dynamin 2 isoform 1 [Homo sapiens]                        114   4e-25
gi|56549119 dynamin 2 isoform 3 [Homo sapiens]                        114   4e-25
gi|56549117 dynamin 1 isoform 2 [Homo sapiens]                        107   5e-23
gi|59853099 dynamin 1 isoform 1 [Homo sapiens]                        107   5e-23
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]                  104   3e-22
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]                  104   3e-22
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]                  104   3e-22
gi|42544243 dynamin 3 isoform a [Homo sapiens]                        103   7e-22
gi|209915561 dynamin 3 isoform b [Homo sapiens]                       103   7e-22
gi|222136619 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|222136617 myxovirus resistance protein 1 [Homo sapiens]            102   2e-21
gi|11342664 myxovirus resistance protein 2 [Homo sapiens]              99   2e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     39   0.017
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...    39   0.022
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...    39   0.022
gi|28173564 keratin 73 [Homo sapiens]                                  39   0.029
gi|148612803 keratin 6 irs4 [Homo sapiens]                             38   0.050
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    38   0.050
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    38   0.050
gi|15618995 keratin 71 [Homo sapiens]                                  37   0.065

>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
          Length = 924

 Score = 1851 bits (4794), Expect = 0.0
 Identities = 924/924 (100%), Positives = 924/924 (100%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKVSDKEKID 180
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKVSDKEKID
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKVSDKEKID 180

Query: 181 QLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLS 240
           QLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLS
Sbjct: 181 QLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLS 240

Query: 241 DYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPH 300
           DYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPH
Sbjct: 241 DYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPH 300

Query: 301 HVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVL 360
           HVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVL
Sbjct: 301 HVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVL 360

Query: 361 VDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMD 420
           VDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMD
Sbjct: 361 VDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMD 420

Query: 421 PHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR 480
           PHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR
Sbjct: 421 PHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR 480

Query: 481 EYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLET 540
           EYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLET
Sbjct: 481 EYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLET 540

Query: 541 EWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENI 600
           EWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENI
Sbjct: 541 EWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENI 600

Query: 601 YLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDI 660
           YLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDI
Sbjct: 601 YLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDI 660

Query: 661 FDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARL 720
           FDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARL
Sbjct: 661 FDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARL 720

Query: 721 KDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITT 780
           KDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITT
Sbjct: 721 KDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITT 780

Query: 781 VRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECND 840
           VRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECND
Sbjct: 781 VRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECND 840

Query: 841 VVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLA 900
           VVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLA
Sbjct: 841 VVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLA 900

Query: 901 EDLKKVREIQEKLDAFIEALHQEK 924
           EDLKKVREIQEKLDAFIEALHQEK
Sbjct: 901 EDLKKVREIQEKLDAFIEALHQEK 924


>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
          Length = 942

 Score = 1840 bits (4765), Expect = 0.0
 Identities = 924/942 (98%), Positives = 924/942 (98%), Gaps = 18/942 (1%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG------------------SPEETAFRATDR 162
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFG                  SPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180

Query: 163 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 222
           GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR
Sbjct: 181 GSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHR 240

Query: 223 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 282
           KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS
Sbjct: 241 KLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGS 300

Query: 283 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 342
           GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS
Sbjct: 301 GEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS 360

Query: 343 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 402
           PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD
Sbjct: 361 PETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQD 420

Query: 403 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 462
           GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY
Sbjct: 421 GSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGY 480

Query: 463 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE
Sbjct: 481 FAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 540

Query: 523 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 582
           SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE
Sbjct: 541 SVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEE 600

Query: 583 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 642
           ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ
Sbjct: 601 ILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 660

Query: 643 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 702
           EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK
Sbjct: 661 EEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDK 720

Query: 703 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 762
           QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM
Sbjct: 721 QQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKM 780

Query: 763 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 822
           LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR
Sbjct: 781 LKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRR 840

Query: 823 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 882
           GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA
Sbjct: 841 GFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFA 900

Query: 883 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924
           EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 901 EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942


>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
          Length = 960

 Score = 1833 bits (4747), Expect = 0.0
 Identities = 924/960 (96%), Positives = 924/960 (96%), Gaps = 36/960 (3%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 150 -----GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKEN 204
                GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKEN
Sbjct: 181 DFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKEN 240

Query: 205 KELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAG 264
           KELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAG
Sbjct: 241 KELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAG 300

Query: 265 KTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALR 324
           KTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALR
Sbjct: 301 KTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALR 360

Query: 325 HEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFS 384
           HEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFS
Sbjct: 361 HEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFS 420

Query: 385 ISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPS 444
           ISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPS
Sbjct: 421 ISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPS 480

Query: 445 RIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 504
           RIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT
Sbjct: 481 RIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 540

Query: 505 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNE 564
           TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNE
Sbjct: 541 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNE 600

Query: 565 ILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW 624
           ILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW
Sbjct: 601 ILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW 660

Query: 625 TDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAED 684
           TDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAED
Sbjct: 661 TDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAED 720

Query: 685 SLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKN 744
           SLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKN
Sbjct: 721 SLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKN 780

Query: 745 RTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQV 804
           RTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQV
Sbjct: 781 RTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQV 840

Query: 805 YRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTN 864
           YRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTN
Sbjct: 841 YRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTN 900

Query: 865 TEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924
           TEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 901 TEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 960


>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
          Length = 961

 Score = 1832 bits (4746), Expect = 0.0
 Identities = 924/961 (96%), Positives = 924/961 (96%), Gaps = 37/961 (3%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHF---------- 170
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHF          
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKGLLGELIL 180

Query: 171 ---------------------------RKVSDKEKIDQLQEELLHTQLKYQRILERLEKE 203
                                      RKVSDKEKIDQLQEELLHTQLKYQRILERLEKE
Sbjct: 181 LQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKE 240

Query: 204 NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA 263
           NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA
Sbjct: 241 NKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSA 300

Query: 264 GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL 323
           GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL
Sbjct: 301 GKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAAL 360

Query: 324 RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF 383
           RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF
Sbjct: 361 RHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIF 420

Query: 384 SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP 443
           SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP
Sbjct: 421 SISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASP 480

Query: 444 SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV 503
           SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV
Sbjct: 481 SRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQV 540

Query: 504 TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN 563
           TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN
Sbjct: 541 TTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKN 600

Query: 564 EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ 623
           EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ
Sbjct: 601 EILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQ 660

Query: 624 WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 683
           WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE
Sbjct: 661 WTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 720

Query: 684 DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK 743
           DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK
Sbjct: 721 DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWK 780

Query: 744 NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 803
           NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ
Sbjct: 781 NRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 840

Query: 804 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 863
           VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT
Sbjct: 841 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 900

Query: 864 NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE 923
           NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE
Sbjct: 901 NTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQE 960

Query: 924 K 924
           K
Sbjct: 961 K 961


>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
          Length = 978

 Score = 1821 bits (4718), Expect = 0.0
 Identities = 924/978 (94%), Positives = 924/978 (94%), Gaps = 54/978 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYI--------------------------------- 147
           QWKDMIPDLSEYKWIVPDIVWEIDEYI                                 
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 148 DF---------------------GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 186
           DF                     GSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL
Sbjct: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEEL 240

Query: 187 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 246
           LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY
Sbjct: 241 LHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASY 300

Query: 247 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 306
           NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK
Sbjct: 301 NTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFK 360

Query: 307 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 366
           DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV
Sbjct: 361 DSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGV 420

Query: 367 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 426
           INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT
Sbjct: 421 INTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRT 480

Query: 427 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 486
           IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF
Sbjct: 481 IFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEF 540

Query: 487 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 546
           FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY
Sbjct: 541 FQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNY 600

Query: 547 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 606
           PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ
Sbjct: 601 PRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQ 660

Query: 607 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 666
           TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE
Sbjct: 661 TMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKE 720

Query: 667 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 726
           AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA
Sbjct: 721 AVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA 780

Query: 727 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 786
           IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE
Sbjct: 781 IENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLE 840

Query: 787 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 846
           SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR
Sbjct: 841 SRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWR 900

Query: 847 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 906
           IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV
Sbjct: 901 IQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKV 960

Query: 907 REIQEKLDAFIEALHQEK 924
           REIQEKLDAFIEALHQEK
Sbjct: 961 REIQEKLDAFIEALHQEK 978


>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
          Length = 979

 Score = 1821 bits (4717), Expect = 0.0
 Identities = 924/979 (94%), Positives = 924/979 (94%), Gaps = 55/979 (5%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------GSPEETAFRATDR 162
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                  GSPEETAFRATDR
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFGHKLVSEVIGASDLLLLLGSPEETAFRATDR 180

Query: 163 GSESDKHF-------------------------------------RKVSDKEKIDQLQEE 185
           GSESDKHF                                     RKVSDKEKIDQLQEE
Sbjct: 181 GSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEE 240

Query: 186 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 245
           LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS
Sbjct: 241 LLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDAS 300

Query: 246 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 305
           YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF
Sbjct: 301 YNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF 360

Query: 306 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 365
           KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG
Sbjct: 361 KDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 420

Query: 366 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 425
           VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR
Sbjct: 421 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 480

Query: 426 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 485
           TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE
Sbjct: 481 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEE 540

Query: 486 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 545
           FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN
Sbjct: 541 FFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNN 600

Query: 546 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 605
           YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA
Sbjct: 601 YPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAA 660

Query: 606 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 665
           QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK
Sbjct: 661 QTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLK 720

Query: 666 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 725
           EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN
Sbjct: 721 EAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTEN 780

Query: 726 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 785
           AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL
Sbjct: 781 AIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNL 840

Query: 786 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 845
           ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW
Sbjct: 841 ESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFW 900

Query: 846 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 905
           RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK
Sbjct: 901 RIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKK 960

Query: 906 VREIQEKLDAFIEALHQEK 924
           VREIQEKLDAFIEALHQEK
Sbjct: 961 VREIQEKLDAFIEALHQEK 979


>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
          Length = 997

 Score = 1814 bits (4699), Expect = 0.0
 Identities = 924/997 (92%), Positives = 924/997 (92%), Gaps = 73/997 (7%)

Query: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
           MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1   MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
           QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61  QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
           QWKDMIPDLSEYKWIVPDIVWEIDEYIDF                               
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 150 -----GSPEETAFRATDRGSESDKHF---------------------------------- 170
                GSPEETAFRATDRGSESDKHF                                  
Sbjct: 181 DFFTSGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYA 240

Query: 171 ---RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 227
              RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS
Sbjct: 241 QQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 300

Query: 228 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 287
           LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT
Sbjct: 301 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 360

Query: 288 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETIS 347
           RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETIS
Sbjct: 361 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETIS 420

Query: 348 LNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDA 407
           LNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDA
Sbjct: 421 LNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDA 480

Query: 408 ERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVT 467
           ERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVT
Sbjct: 481 ERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVT 540

Query: 468 GKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQ 527
           GKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQ
Sbjct: 541 GKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQ 600

Query: 528 ADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQS 587
           ADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQS
Sbjct: 601 ADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQS 660

Query: 588 LWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSR 647
           LWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSR
Sbjct: 661 LWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSR 720

Query: 648 FMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDA 707
           FMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDA
Sbjct: 721 FMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDA 780

Query: 708 AIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNE 767
           AIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNE
Sbjct: 781 AIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNELEKMLKCNE 840

Query: 768 EHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYY 827
           EHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYY
Sbjct: 841 EHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCNLCRRGFYYY 900

Query: 828 QRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEK 887
           QRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEK
Sbjct: 901 QRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEK 960

Query: 888 KIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924
           KIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 961 KIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 997


>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
          Length = 1015

 Score = 1803 bits (4670), Expect = 0.0
 Identities = 924/1015 (91%), Positives = 924/1015 (91%), Gaps = 91/1015 (8%)

Query: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
            MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1    MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60

Query: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
            QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61   QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120

Query: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYI--------------------------------- 147
            QWKDMIPDLSEYKWIVPDIVWEIDEYI                                 
Sbjct: 121  QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180

Query: 148  DF---------------------GSPEETAFRATDRGSESDKHFRK-------------- 172
            DF                     GSPEETAFRATDRGSESDKHFRK              
Sbjct: 181  DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240

Query: 173  -----------------------VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 209
                                   VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 241  EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300

Query: 210  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 269
            LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 301  LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360

Query: 270  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 329
            EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 361  EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420

Query: 330  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 389
            RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 421  RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480

Query: 390  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 449
            MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 481  MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540

Query: 450  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 509
            IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 541  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600

Query: 510  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 569
            LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 601  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660

Query: 570  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 629
            ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 661  ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720

Query: 630  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 689
            PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 721  PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780

Query: 690  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 749
            QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 781  QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840

Query: 750  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 809
            CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 841  CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900

Query: 810  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 869
            LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 901  LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960

Query: 870  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924
            LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 961  LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015


>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 523 SVEQQADSFKATRFNLE---TEWKNNYP 547
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 523 SVEQQADSFKATRFNLE---TEWKNNYP 547
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
          Length = 870

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 523 SVEQQADSFKATRFNLE---TEWKNNYP 547
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
          Length = 866

 Score =  114 bits (285), Expect = 4e-25
 Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + +++ D  S    S +    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
             R  +   +     H       S++F      D   +R EIE    +       +SP  
Sbjct: 65  TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   +++IL +   ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       E    I A    E +FF +    +     A ++ T +L   ++      +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291

Query: 523 SVEQQADSFKATRFNLE---TEWKNNYP 547
           S+       ++   +LE    E+KN  P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319


>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
          Length = 851

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKG---NSSESIEAIREYEEEFF 487
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
          Length = 864

 Score =  107 bits (267), Expect = 5e-23
 Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + + + D  S      N    LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
           +TR P+ + L       A F     +    K  D   +R EIE    +       +SP  
Sbjct: 64  VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + LVDLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    +  ++DP G+RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234

Query: 466 VTGKG---NSSESIEAIREYEEEFF 487
           V       +  + I A    E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259


>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
          Length = 736

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 286 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 329
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 330 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 389
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 390 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 449
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 450 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 488
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
          Length = 699

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 286 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 329
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 330 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 389
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 390 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 449
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 450 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 488
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
          Length = 710

 Score =  104 bits (260), Expect = 3e-22
 Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           ++LI + +++ DV +   A       LP++VVVG QS+GK+SVLE +    + PRG+G +
Sbjct: 2   EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57

Query: 286 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 329
           +TR P+ + L     HV+     K +  E  +  EE             D   +R EIE 
Sbjct: 58  VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113

Query: 330 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 389
              +       VSPE I L +  P +  + LVDLPG+          D +  I  +   +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173

Query: 390 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 449
           + NPN+IIL +   + D   S    +  ++DP GRRT+ V+TK+DL +    +      +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229

Query: 450 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 488
           + G++ P+K LG   VV        N     ++IR+ E  F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270


>gi|42544243 dynamin 3 isoform a [Homo sapiens]
          Length = 863

 Score =  103 bits (257), Expect = 7e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 466 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 523 SVEQQADSFKATRFNLETE---WKNNYP 547
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|209915561 dynamin 3 isoform b [Homo sapiens]
          Length = 859

 Score =  103 bits (257), Expect = 7e-22
 Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)

Query: 226 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 285
           + LI + + + D  S    S   +  LP++ VVG QSAGK+SVLE        PRGSG +
Sbjct: 7   EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63

Query: 286 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 345
           +TR P+ + L       A F     +    K  D   +R EIE    +       +S   
Sbjct: 64  VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

Query: 346 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 405
           I+L V  P +  + L+DLPG+         PD +  I  +   ++   N +IL +   + 
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179

Query: 406 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           D   S    L  ++DP G RTI V+TK+DL ++   +    + ++E KL P++  GY  V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234

Query: 466 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 522
           V       +  + I+A    E +FF +    +     A ++ T +L   ++      +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291

Query: 523 SVEQQADSFKATRFNLETE---WKNNYP 547
           ++    +  +    ++E E   +KN  P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319


>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 211 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 269
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 270 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 328
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 329 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 388
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 389 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 448
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 449 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 504
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 505 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 560
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 561 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 616
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 617 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 674
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
          Length = 662

 Score =  102 bits (253), Expect = 2e-21
 Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)

Query: 211 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 269
           V QK+   +    L     +     +D++    A    QD  LP + V+GDQS+GK+SVL
Sbjct: 28  VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87

Query: 270 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 328
           E ++   + PRGSG ++TR P+ + L +  +      K S +++++ +  D + +  EI 
Sbjct: 88  EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144

Query: 329 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 388
                   EG  +S E I+L +    +  + L+DLPG+          D    I ++ K 
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204

Query: 389 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 448
           Y+Q    I L +   +VD   +    +  ++DP G RTI +LTK DL +K   +  ++  
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262

Query: 449 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 504
           ++   +F +K  GY  +V  +G        S+    + E+ FF+N    +  +L+  + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319

Query: 505 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 560
              L+  ++      + +S+    +  K T   +  E +     + E D NE    L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378

Query: 561 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 616
             N    ++ +L Q      EE ++     R   H    +IEN +    + +     +  
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432

Query: 617 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 674
           +     Q+  ++LP       +ET+ ++  + + EP       + D ++ A  + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490


>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
          Length = 715

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)

Query: 252 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 311
           LP + V+GDQS+GK+SVLE ++   + PRGSG ++TR P+ + L + P      + S R 
Sbjct: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175

Query: 312 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 371
            +L + +D   +  EI          G  +S E ISL +  P +  + ++DLPG+     
Sbjct: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234

Query: 372 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 431
                D    I ++ K Y+Q    I L +   +VD   +    +  ++DP G RTI +LT
Sbjct: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294

Query: 432 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
           K DL ++   +   +  ++    +P+K  GY  V
Sbjct: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 39.3 bits (90), Expect = 0.017
 Identities = 145/792 (18%), Positives = 311/792 (39%), Gaps = 129/792 (16%)

Query: 175  DKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSL---IDM 231
            DK K+ +L  +L  T  ++Q +    EK NK L       +DK +  +KL + L   +D+
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL-------EDKSLEFKKLSEELAIQLDI 1219

Query: 232  YSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 291
              +  + L +   +        +   +  + +        + +A +    +   +     
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279

Query: 292  KVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVK 351
            ++T  +   +++ F+ ++ + +  KE  + +++ +IE           ++  E  +L  +
Sbjct: 1280 QLTEEQNTLNIS-FQQATHQLE-EKENQIKSMKADIE-----------SLVTEKEALQKE 1326

Query: 352  GPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSI 411
            G   Q+                 A + +  I  + K   +N NA+ L  ++  +  ++  
Sbjct: 1327 GGNQQQA----------------ASEKESCITQLKKELSENINAVTLMKEE--LKEKKVE 1368

Query: 412  VTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGK---LFPMKALGYFAVVTG 468
            ++ L  Q+       + +   + L+EK  A  S  +Q  E K   L  ++ L  F V T 
Sbjct: 1369 ISSLSKQLTD---LNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVDTL 1424

Query: 469  KGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVS---------DCFWKM 519
                  ++E + ++  +F +  K  + S    HQ T + L + +          D    +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQ-SRFTQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 520  VRESVEQQADSFKATR--------------FNLETEWKNNYPRLRELDRNELFEKAKNEI 565
            ++E ++QQ   F   +               NLETE K+   R+ EL+ +   +  + E 
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543

Query: 566  LDEVI-SLSQVTPKHWEEILQ-----QSLWERVSTHVIE----------NIYLPAAQTMN 609
            L+EV+ + +Q      +E++Q     Q L E     V E           +Y   A+   
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603

Query: 610  SGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVK 669
                   V++ +K    K+   KA+E   + L+ E +  + E K K    I    K+ + 
Sbjct: 1604 KKKELEHVNLSVK---SKEEELKALE---DRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657

Query: 670  EESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENA-IE 728
            +   K  ++    E  L  +          +  Q+ +  ++ +EE    +LK  E++  E
Sbjct: 1658 QMEEKEEQYKKGTESHLSELN---------TKLQEREREVHILEE----KLKSVESSQSE 1704

Query: 729  NMVGPDWKKRWLYWKNRTQ---EQCV---HNETKNELEKMLKCNEEHPAYLASDEITTVR 782
             ++ P   K    +  + +   + CV   + E  + L++ L   E+    +  ++  TV 
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764

Query: 783  KNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNH----CNLCRRGFYYYQRHFVDSELEC 838
             + E R  +    LIK   H   ++H  ++ + H         + +       V+ E   
Sbjct: 1765 SHFEMR-CQYQERLIK-LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822

Query: 839  NDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQ 898
            N++     ++ +      TL+++    ++  LE+ +KE+  D     +K++      RV+
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQI--LEQKIKEL--DSCLVRQKEV-----HRVE 1873

Query: 899  LAEDLKKVREIQ 910
            + E   K  ++Q
Sbjct: 1874 MEELTSKYEKLQ 1885



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 125/656 (19%), Positives = 251/656 (38%), Gaps = 135/656 (20%)

Query: 165  ESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK---LVLQKDDKGIHH 221
            ES KH +     EK+  L+++    Q + +++ E+ E+E + L K   ++ Q   + ++ 
Sbjct: 617  ESLKHQQDALWTEKLQVLKQQY---QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673

Query: 222  RKLKK------SLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLE--MIA 273
            + L+K       L  + SE+ +VL    A +  ++ L    V+ DQ+      LE  M  
Sbjct: 674  KTLEKLDVKQTELESLSSELSEVLK---ARHKLEEELS---VLKDQTDKMKQELEAKMDE 727

Query: 274  QARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLT-KEEDLAALRHEIELR-M 331
            Q     +    ++    V +  +E        KD   + +L  KE D     H+  +  +
Sbjct: 728  QKNHHQQQVDSIIKEHEVSIQRTE-----KALKDQINQLELLLKERDKHLKEHQAHVENL 782

Query: 332  RKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQ 391
              ++K              +G   Q    +D+     + T       +E +  + +  + 
Sbjct: 783  EADIKRS------------EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830

Query: 392  -NPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSR-IQQI 449
                 I+L  Q   V+A++    D+ +++D H  +   ++ +++     +    + + Q+
Sbjct: 831  LETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887

Query: 450  IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 509
             E KL             G     ++ + + E E    Q    ++    K  ++ T+ LS
Sbjct: 888  YESKL-----------EDGNKEQEQTKQILVEKENMILQ----MREGQKKEIEILTQKLS 932

Query: 510  LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRN--ELFEKAKNEILD 567
                             + DS        ET++KN   ++ ++ +   E+ E  K ++LD
Sbjct: 933  A----------------KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD 976

Query: 568  EVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDK 627
            +   L +       E+ Q+   ++ +  ++E      AQ  ++G  +    +        
Sbjct: 977  QEAKLKKELENTALELSQKE--KQFNAKMLE-----MAQANSAGISDAVSRL-------- 1021

Query: 628  QLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLR 687
                       ET Q+E    +TE   +E +D+           SI   K N  AE+ L+
Sbjct: 1022 -----------ETNQKEQIESLTEVHRRELNDVI----------SIWEKKLNQQAEE-LQ 1059

Query: 688  VIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQ 747
             I    L+++     +     + F  E  +   + T               WL      +
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT---------------WL-----KE 1099

Query: 748  EQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 803
            E    + T NEL++ LK    H   LA DE T ++ +LE   V+++ SL ++T+ Q
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDE-TKLKAHLEKLEVDLNKSLKENTFLQ 1154


>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 476  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 535
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 536  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 595
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 596  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 644
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 645  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 697
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 698  SIS 700
             +S
Sbjct: 1388 EVS 1390


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 38.9 bits (89), Expect = 0.022
 Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)

Query: 476  IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 535
            +  +     + F+  K LK  +++        LS        +   E + QQ + ++A  
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209

Query: 536  FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 595
             NLE + +      +E DR +L +K   E  DE I  +    K   E++++ L E+V   
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267

Query: 596  VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 644
              +    PA  +    + +   +++ K   +K    + +E   +   EE           
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327

Query: 645  ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 697
                F+  +T  K ++ +   D+ DKLK  ++++   +      +ED  R+++     + 
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387

Query: 698  SIS 700
             +S
Sbjct: 1388 EVS 1390


>gi|28173564 keratin 73 [Homo sapiens]
          Length = 540

 Score = 38.5 bits (88), Expect = 0.029
 Identities = 23/72 (31%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 840 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 899
           D V F   Q  +  T   L QQL   ++   + N++ +LE +  +  K+++ L+G RV+L
Sbjct: 148 DKVRFLEQQNQVLETKWELLQQL---DLNNCKNNLEPILEGYISNLRKQLETLSGDRVRL 204

Query: 900 AEDLKKVREIQE 911
             +L+ VRE+ E
Sbjct: 205 DSELRSVREVVE 216


>gi|148612803 keratin 6 irs4 [Homo sapiens]
          Length = 529

 Score = 37.7 bits (86), Expect = 0.050
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 3/72 (4%)

Query: 840 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 899
           D V F   Q  +  T   L QQL   ++   +KN++ +LE +  +  K+++ L+G RV+L
Sbjct: 156 DKVRFLEQQNQVLETKWELLQQL---DLNNCKKNLEPILEGYISNLRKQLETLSGDRVRL 212

Query: 900 AEDLKKVREIQE 911
             +L+ +R++ E
Sbjct: 213 DSELRSMRDLVE 224


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 37.7 bits (86), Expect = 0.050
 Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)

Query: 532  KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 586
            K    NL  E KN+Y  L+    +E  +K+ + I+D++   L  VT K+ E+ L+     
Sbjct: 717  KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 773

Query: 587  ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 642
                SL + VS   +E +++P  +         +  ++LK+    +L  K  E      Q
Sbjct: 774  LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 825

Query: 643  EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 686
            E+     +E               K H+++     D L +  +E    + K+ D  ++ +
Sbjct: 826  EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 885

Query: 687  RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 746
            ++   N +  R++ + Q    A Y      +A++     ++  +   + +    Y K + 
Sbjct: 886  KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 945

Query: 747  QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 803
            +   +H E K    EL+ + +C +   A + S E     +  ++   E+   L + T   
Sbjct: 946  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1003

Query: 804  VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 863
                  +K      +  ++  +  Q+   D  +    +     ++R L+   + L +QL 
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1060

Query: 864  N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 901
            +     TEV+ +     E+N K+  E  A            E  E   K L G    L E
Sbjct: 1061 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1120

Query: 902  DLKKVREIQEKLDAFIEALHQ 922
            +LK ++   EK    +  LHQ
Sbjct: 1121 ELKSMQRCYEKEQQTVTKLHQ 1141


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 37.7 bits (86), Expect = 0.050
 Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)

Query: 532  KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 586
            K    NL  E KN+Y  L+    +E  +K+ + I+D++   L  VT K+ E+ L+     
Sbjct: 730  KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 786

Query: 587  ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 642
                SL + VS   +E +++P  +         +  ++LK+    +L  K  E      Q
Sbjct: 787  LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 838

Query: 643  EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 686
            E+     +E               K H+++     D L +  +E    + K+ D  ++ +
Sbjct: 839  EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898

Query: 687  RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 746
            ++   N +  R++ + Q    A Y      +A++     ++  +   + +    Y K + 
Sbjct: 899  KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958

Query: 747  QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 803
            +   +H E K    EL+ + +C +   A + S E     +  ++   E+   L + T   
Sbjct: 959  EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1016

Query: 804  VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 863
                  +K      +  ++  +  Q+   D  +    +     ++R L+   + L +QL 
Sbjct: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1073

Query: 864  N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 901
            +     TEV+ +     E+N K+  E  A            E  E   K L G    L E
Sbjct: 1074 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1133

Query: 902  DLKKVREIQEKLDAFIEALHQ 922
            +LK ++   EK    +  LHQ
Sbjct: 1134 ELKSMQRCYEKEQQTVTKLHQ 1154


>gi|15618995 keratin 71 [Homo sapiens]
          Length = 523

 Score = 37.4 bits (85), Expect = 0.065
 Identities = 22/72 (30%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 840 DVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQL 899
           D V F   Q  +  T   L QQL   ++   + N++ +LE +  +  K+++ L+G RV+L
Sbjct: 146 DKVRFLEQQNQVLETKWELLQQL---DLNNCKNNLEPILEGYISNLRKQLETLSGDRVRL 202

Query: 900 AEDLKKVREIQE 911
             +L+ VR++ E
Sbjct: 203 DSELRNVRDVVE 214


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,246,070
Number of Sequences: 37866
Number of extensions: 1473423
Number of successful extensions: 6966
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 6675
Number of HSP's gapped (non-prelim): 408
length of query: 924
length of database: 18,247,518
effective HSP length: 112
effective length of query: 812
effective length of database: 14,006,526
effective search space: 11373299112
effective search space used: 11373299112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.