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Search of human proteins with 188528689
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188528689 syntaxin binding protein 2 isoform a [Homo
sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188528689 syntaxin binding protein 2 isoform a [Homo sapiens] 1172 0.0
gi|188528901 syntaxin binding protein 2 isoform b [Homo sapiens] 1162 0.0
gi|73760415 syntaxin binding protein 1 isoform b [Homo sapiens] 763 0.0
gi|4507297 syntaxin binding protein 1 isoform a [Homo sapiens] 760 0.0
gi|118600975 syntaxin binding protein 3 [Homo sapiens] 529 e-150
gi|18105063 vacuolar protein sorting 45A [Homo sapiens] 129 6e-30
gi|33469966 vesicle transport-related protein isoform a [Homo sa... 88 2e-17
gi|33469978 vesicle transport-related protein isoform b [Homo sa... 75 1e-13
gi|18105056 vacuolar protein sorting 33A [Homo sapiens] 50 6e-06
gi|119829191 vacuolar protein sorting 33B (yeast homolog)) [Homo... 50 8e-06
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 35 0.15
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 35 0.15
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 35 0.25
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 33 0.97
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 32 1.3
gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens] 32 1.3
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 32 1.6
gi|37595541 tripartite motif-containing 69 isoform b [Homo sapiens] 32 2.2
gi|117414154 sodium channel associated protein 2 isoform b [Homo... 31 2.8
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 31 2.8
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 31 3.7
gi|212549782 caspase 8 associated protein 2 [Homo sapiens] 31 3.7
gi|6912288 caspase 8 associated protein 2 [Homo sapiens] 31 3.7
gi|212549532 caspase 8 associated protein 2 [Homo sapiens] 31 3.7
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 30 4.8
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 30 4.8
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 30 6.3
gi|154813191 IQ motif containing E isoform 1 [Homo sapiens] 30 6.3
gi|154813193 IQ motif containing E isoform 2 [Homo sapiens] 30 6.3
gi|134244285 Notch homolog 3 [Homo sapiens] 30 8.2
>gi|188528689 syntaxin binding protein 2 isoform a [Homo sapiens]
Length = 593
Score = 1172 bits (3032), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
Sbjct: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
Query: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR
Sbjct: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
Query: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 180
SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC
Sbjct: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 180
Query: 181 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 240
ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV
Sbjct: 181 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 240
Query: 241 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 300
SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS
Sbjct: 241 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 300
Query: 301 KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS 360
KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS
Sbjct: 301 KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS 360
Query: 361 VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE 420
VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE
Sbjct: 361 VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE 420
Query: 421 NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK 480
NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK
Sbjct: 421 NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK 480
Query: 481 DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG 540
DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG
Sbjct: 481 DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG 540
Query: 541 GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP 593
GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP
Sbjct: 541 GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP 593
>gi|188528901 syntaxin binding protein 2 isoform b [Homo sapiens]
Length = 590
Score = 1162 bits (3005), Expect = 0.0
Identities = 590/593 (99%), Positives = 590/593 (99%), Gaps = 3/593 (0%)
Query: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED
Sbjct: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
Query: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
INKRREPIPSLEAIYLLSPTEK ALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR
Sbjct: 61 INKRREPIPSLEAIYLLSPTEK---ALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 117
Query: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 180
SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC
Sbjct: 118 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 177
Query: 181 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 240
ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV
Sbjct: 178 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 237
Query: 241 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 300
SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS
Sbjct: 238 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 297
Query: 301 KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS 360
KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS
Sbjct: 298 KKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGS 357
Query: 361 VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE 420
VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE
Sbjct: 358 VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE 417
Query: 421 NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK 480
NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK
Sbjct: 418 NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIK 477
Query: 481 DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG 540
DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG
Sbjct: 478 DVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMG 537
Query: 541 GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP 593
GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP
Sbjct: 538 GVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP 590
>gi|73760415 syntaxin binding protein 1 isoform b [Homo sapiens]
Length = 594
Score = 763 bits (1970), Expect = 0.0
Identities = 377/594 (63%), Positives = 478/594 (80%), Gaps = 4/594 (0%)
Query: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
MAP GLKAVVGEKI+ VI+ VKK GEWKVL++D SMR+LSSCCKM+DI+ EGITIVED
Sbjct: 1 MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVED 60
Query: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
INKRREP+PSLEA+YL++P+EKSV +LI DF+ PT Y+AAH+FFTD+CP+ LF+EL +
Sbjct: 61 INKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVK 120
Query: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 180
SR AKV+KTL EI++AFLPYE+QV+SLD+ S + Y P +A+ + LE LA+QIATLC
Sbjct: 121 SRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLC 180
Query: 181 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 240
ATL+EYPA+RYR +D A LA + KL+A+KAD P++GEGP+K RSQLLI+DR DP
Sbjct: 181 ATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPS 240
Query: 241 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 300
SP+LHELTFQAM+YDLL IE D Y+YET+G+ EAR K VLLDEDDDLW+ LRH HIA+VS
Sbjct: 241 SPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVS 300
Query: 301 KKVTELLRTFCESKRLTT-DKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKG 359
++VT L+ F SKR+ T +K ++DLSQ+LKKMPQYQKEL+KYSTHLHLA+DCMKH++G
Sbjct: 301 QEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQG 360
Query: 360 SVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSE 419
+V+KLC VEQDLAMG+DAEGEKIKD M+ IVP+LLDA V YDKIR++LLYI L+NG++E
Sbjct: 361 TVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITE 420
Query: 420 ENLAKLIQHANVQAH-SSLIRNLEQLGGTVTNPGGSGTSSRLEPRERM-EPTYQLSRWTP 477
ENL KLIQHA + S +I N+ LG + S+ E +ER+ E TYQLSRWTP
Sbjct: 421 ENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTP 480
Query: 478 VIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVY 537
+IKD+MED +ED+LD +P++S + + S AVSAR+GHWHKNKA E R+GPRLI++
Sbjct: 481 IIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIF 540
Query: 538 VMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIA 591
++GGV+++EMR AYEVT+A GKWEVLIGS+HILTP + LD LK L+K E+I+
Sbjct: 541 ILGGVSLNEMRCAYEVTQA-NGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEIS 593
>gi|4507297 syntaxin binding protein 1 isoform a [Homo sapiens]
Length = 603
Score = 760 bits (1962), Expect = 0.0
Identities = 375/587 (63%), Positives = 474/587 (80%), Gaps = 4/587 (0%)
Query: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
MAP GLKAVVGEKI+ VI+ VKK GEWKVL++D SMR+LSSCCKM+DI+ EGITIVED
Sbjct: 1 MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVED 60
Query: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
INKRREP+PSLEA+YL++P+EKSV +LI DF+ PT Y+AAH+FFTD+CP+ LF+EL +
Sbjct: 61 INKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVK 120
Query: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLC 180
SR AKV+KTL EI++AFLPYE+QV+SLD+ S + Y P +A+ + LE LA+QIATLC
Sbjct: 121 SRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLC 180
Query: 181 ATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPV 240
ATL+EYPA+RYR +D A LA + KL+A+KAD P++GEGP+K RSQLLI+DR DP
Sbjct: 181 ATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPS 240
Query: 241 SPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVS 300
SP+LHELTFQAM+YDLL IE D Y+YET+G+ EAR K VLLDEDDDLW+ LRH HIA+VS
Sbjct: 241 SPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVS 300
Query: 301 KKVTELLRTFCESKRLTT-DKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKG 359
++VT L+ F SKR+ T +K ++DLSQ+LKKMPQYQKEL+KYSTHLHLA+DCMKH++G
Sbjct: 301 QEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQG 360
Query: 360 SVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSE 419
+V+KLC VEQDLAMG+DAEGEKIKD M+ IVP+LLDA V YDKIR++LLYI L+NG++E
Sbjct: 361 TVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITE 420
Query: 420 ENLAKLIQHANVQAH-SSLIRNLEQLGGTVTNPGGSGTSSRLEPRERM-EPTYQLSRWTP 477
ENL KLIQHA + S +I N+ LG + S+ E +ER+ E TYQLSRWTP
Sbjct: 421 ENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTP 480
Query: 478 VIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVY 537
+IKD+MED +ED+LD +P++S + + S AVSAR+GHWHKNKA E R+GPRLI++
Sbjct: 481 IIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIF 540
Query: 538 VMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALD 584
++GGV+++EMR AYEVT+A GKWEVLIGS+HILTPT+FL DL+ D
Sbjct: 541 ILGGVSLNEMRCAYEVTQA-NGKWEVLIGSTHILTPTKFLMDLRHPD 586
>gi|118600975 syntaxin binding protein 3 [Homo sapiens]
Length = 592
Score = 529 bits (1362), Expect = e-150
Identities = 277/598 (46%), Positives = 407/598 (68%), Gaps = 20/598 (3%)
Query: 1 MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVED 60
+A GLK+VV +KI + V KK+GEWK++++D + ++L+SCCKM+D+L EGIT+VE+
Sbjct: 5 VAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVEN 64
Query: 61 INKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGR 120
I K REP+ ++A+Y ++PT KSV + DF YKAA+I+FTD CP+ LF+++ +
Sbjct: 65 IYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKI-K 123
Query: 121 SRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPF--RAEERTRQLEVLAQQIAT 178
+ +K ++ KEI+++F+P+E+QV++LD P + Y Y P A+ + +E +A QI T
Sbjct: 124 ASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVT 183
Query: 179 LCATLQEYPAIRYRKGPEDTA-QLAHAVLAKL-NAFKADTPSLGEGPEKTRSQLLIMDRA 236
+CATL E P +RY+ P D A +LA V KL + +K D SL +G KT SQLLI+DR
Sbjct: 184 VCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKG--KTHSQLLIIDRG 241
Query: 237 ADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHI 296
DPVS +LHELTFQAMAYDLL IE DTY+Y+T G +EK +L+E+DDLWV +RH HI
Sbjct: 242 FDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDG----KEKEAILEEEDDLWVRIRHRHI 297
Query: 297 ADVSKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKH 356
A V +++ +L++ +K+ T K ++ L+Q++KKMP ++K++ K HL+LA+DCM
Sbjct: 298 AVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNK 357
Query: 357 FKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNG 416
FK ++EKLC EQDLA+G+DAEG+K+KDSM++++PVLL+ DKIR +LLYI NG
Sbjct: 358 FKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSING 417
Query: 417 VSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWT 476
+EENL +LIQ+ ++ S +IRN LG + G R + E T+QLSRWT
Sbjct: 418 TTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKD--RSAEETFQLSRWT 475
Query: 477 PVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGI--EARAGPRL 534
P IKD+MEDA+++RLD WP+ S + AVSAR K +A + + G +L
Sbjct: 476 PFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSAR----QKPRANYLEDRKNGSKL 531
Query: 535 IVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIAL 592
IV+V+GG+ SE+R AYEV++A + EV+IGS+H+LTP + LDD+K L+K + ++L
Sbjct: 532 IVFVIGGITYSEVRCAYEVSQAHK-SCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSL 588
>gi|18105063 vacuolar protein sorting 45A [Homo sapiens]
Length = 570
Score = 129 bits (325), Expect = 6e-30
Identities = 131/578 (22%), Positives = 250/578 (43%), Gaps = 75/578 (12%)
Query: 29 KVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKR-REPIPSLEAIYLLSPTEKSVQAL 87
KVL+MD + I+S S+IL + + + E I+ + RE + L+AI L PT+++V +
Sbjct: 23 KVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVDYI 82
Query: 88 IKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSL 147
I++ + Y I+F++ + L + +VV ++E + ++ +FSL
Sbjct: 83 IQELRRPK---YTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSL 139
Query: 148 DAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLA 207
+ L C QL Q + L +L++ P IRY+ E +LA V
Sbjct: 140 NI------LGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQ 193
Query: 208 KLNAF-------KADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIE 260
+ + + P L LLI+DR D ++PLL++ T+QAM ++LL I
Sbjct: 194 VITKEYELFEFRRTEVPPL----------LLILDRCDDAITPLLNQWTYQAMVHELLGIN 243
Query: 261 QDTYRY-ETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLTTD 319
+ G+S+ + VL E+D+ + +++ A++ + L+ F + K
Sbjct: 244 NNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQ 303
Query: 320 K-ANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHF-KGSVEKLCSVEQDLAMGSDA 377
K +I D+ ++ PQ++K S H+ + + + + ++ ++ VEQ+LA +D
Sbjct: 304 KLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDH 363
Query: 378 EGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSL 437
+++ I +L + V +D R+++LY L S +L L+ + S
Sbjct: 364 -----SSALQNIKRLLQNPKVTEFDAARLVMLYALHYERHSSNSLPGLMMDLRNKGVSEK 418
Query: 438 IRNLEQLGGTVTNPGGSGT--SSRLEPRERMEPTYQL-----------SRWTPVIKDVME 484
R +L V GG S P++ + T Q ++ P + + ++
Sbjct: 419 YR---KLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLD 475
Query: 485 DAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAM 544
++ RL NL+P++ Q +IV+V+GG
Sbjct: 476 HLIKGRLKENLYPYLGPSTLRDRPQ-----------------------DIIVFVIGGATY 512
Query: 545 SEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKA 582
E Y + R T G +++G + + FL+++ A
Sbjct: 513 EEALTVYNLNRTTPGV-RIVLGGTTVHNTKSFLEEVLA 549
>gi|33469966 vesicle transport-related protein isoform a [Homo
sapiens]
Length = 642
Score = 88.2 bits (217), Expect = 2e-17
Identities = 129/629 (20%), Positives = 244/629 (38%), Gaps = 99/629 (15%)
Query: 28 WKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQAL 87
WKVLI D I+S + ++ GIT+ ++ R+PIP + A+Y + PTE+++ +
Sbjct: 43 WKVLIYDRFGQDIISPLLSVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRM 102
Query: 88 IKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLA-----KVVKTLKEIHLAFLPYEA 142
+D + Y++ ++ F ++ + LA +V K + +L F+ E
Sbjct: 103 CQDLRNQ---LYESYYLNFISAISRSKLEDIANAALAASAVTQVAKVFDQ-YLNFITLED 158
Query: 143 QVFSLDAPHSTYNLYCPFRAEERT-----RQLEVLAQQIATLCATLQEYPAIRYRKGPED 197
+F L + Y + T ++ + + TL P IR +G
Sbjct: 159 DMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRG--T 216
Query: 198 TAQLAHAVL----------AKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHEL 247
A++ L A+ + F DT G+ + R L+++DR D +PL H
Sbjct: 217 AAEMVAVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQ-RPLLVLVDRNIDLATPLHHTW 275
Query: 248 TFQAMAYDLLDIEQDTYRY-ETTGLSEA---------REKAVLLDEDDDLWVELRHMHIA 297
T+QA+ +D+LD + E++G+ + +K+ L D W + +
Sbjct: 276 TYQALVHDVLDFHLNRVNLEESSGVENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFP 335
Query: 298 DVSKKVTELLRTF----CESKRLTTDKA--------------NIKDLSQILKKMPQYQKE 339
+V++ V + L ++ E KRL + N L+ + +P+ ++
Sbjct: 336 EVAESVQQELESYRAQEDEVKRLKSIMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEK 395
Query: 340 LNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVP 399
H ++A ++H K + ++ M + + D + DA P
Sbjct: 396 KRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTTLDKSLLDIIS-----DPDAGTP 450
Query: 400 AYDKIRVLLLYILLRNGVSEE---------------NLAKLIQHANVQAHSSLIRNLEQL 444
DK+R+ L+Y + E NL L +A + +
Sbjct: 451 E-DKMRLFLIYYISTQQAPSEADLEQYKKALTDAGCNLNPLQYIKQWKAFTKMASAPASY 509
Query: 445 GGTVTNPGG-------SGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWP 497
G T T P G +G+ +E + + Q T ++ ++ME D +
Sbjct: 510 GSTTTKPMGLLSRVMNTGSQFVMEGVKNLVLKQQNLPVTRILDNLMEMKSNPETDDYRY- 568
Query: 498 FVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRAT 557
DP + ++V +NK + IV+V+GG E + + +
Sbjct: 569 --FDPKMLRGNDSSVP-------RNKNPFQ-----EAIVFVVGGGNYIEYQNLVDYIKGK 614
Query: 558 EGKWEVLIGSSHILTPTRFLDDLKALDKK 586
+GK +L G S + T+F+ L L +K
Sbjct: 615 QGK-HILYGCSELFNATQFIKQLSQLGQK 642
>gi|33469978 vesicle transport-related protein isoform b [Homo
sapiens]
Length = 575
Score = 75.5 bits (184), Expect = 1e-13
Identities = 121/603 (20%), Positives = 232/603 (38%), Gaps = 99/603 (16%)
Query: 54 GITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEP 113
GIT+ ++ R+PIP + A+Y + PTE+++ + +D + Y++ ++ F
Sbjct: 2 GITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRMCQDLRNQ---LYESYYLNFISAISRS 58
Query: 114 LFSELGRSRLA-----KVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERT-- 166
++ + LA +V K + +L F+ E +F L + Y + T
Sbjct: 59 KLEDIANAALAASAVTQVAKVFDQ-YLNFITLEDDMFVLCNQNKELVSYRAINRPDITDT 117
Query: 167 ---RQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVL----------AKLNAFK 213
++ + + TL P IR +G A++ L A+ + F
Sbjct: 118 EMETVMDTIVDSLFCFFVTLGAVPIIRCSRG--TAAEMVAVKLDKKLRENLRDARNSLFT 175
Query: 214 ADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRY-ETTGLS 272
DT G+ + R L+++DR D +PL H T+QA+ +D+LD + E++G+
Sbjct: 176 GDTLGAGQFSFQ-RPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGVE 234
Query: 273 EA---------REKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTF----CESKRLTTD 319
+ +K+ L D W + + +V++ V + L ++ E KRL +
Sbjct: 235 NSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSI 294
Query: 320 KA--------------NIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLC 365
N L+ + +P+ ++ H ++A ++H K +
Sbjct: 295 MGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVY 354
Query: 366 SVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEE----- 420
++ M + + D + DA P DK+R+ L+Y + E
Sbjct: 355 FEYEEKIMSKTTLDKSLLDIIS-----DPDAGTPE-DKMRLFLIYYISTQQAPSEADLEQ 408
Query: 421 ----------NLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGG-------SGTSSRLEPR 463
NL L +A + + G T T P G +G+ +E
Sbjct: 409 YKKALTDAGCNLNPLQYIKQWKAFTKMASAPASYGSTTTKPMGLLSRVMNTGSQFVMEGV 468
Query: 464 ERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNK 523
+ + Q T ++ ++ME D + DP + ++V +NK
Sbjct: 469 KNLVLKQQNLPVTRILDNLMEMKSNPETDDYRY---FDPKMLRGNDSSVP-------RNK 518
Query: 524 AGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKAL 583
+ IV+V+GG E + + + +GK +L G S + T+F+ L L
Sbjct: 519 NPFQ-----EAIVFVVGGGNYIEYQNLVDYIKGKQGK-HILYGCSELFNATQFIKQLSQL 572
Query: 584 DKK 586
+K
Sbjct: 573 GQK 575
>gi|18105056 vacuolar protein sorting 33A [Homo sapiens]
Length = 596
Score = 50.1 bits (118), Expect = 6e-06
Identities = 93/487 (19%), Positives = 194/487 (39%), Gaps = 70/487 (14%)
Query: 131 KEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIR 190
+E L +P++ + S+++ + Y E L A+ + TL A P I
Sbjct: 138 EEYSLDLIPFDGDLLSMESEGAFKECYL----EGDQTSLYHAAKGLMTLQALYGTIPQI- 192
Query: 191 YRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQ 250
+ KG E Q+A+ ++ F S+ LL++DR D ++PL +LT++
Sbjct: 193 FGKG-ECARQVANMMIRMKREFTGSQNSIFP----VFDNLLLLDRNVDLLTPLATQLTYE 247
Query: 251 AMAYDLLDIEQDTYRYETTGLSEARE-----------KAVLLDEDDDLWVELRHMHIADV 299
+ ++ I+ + + ++ K + L+ ++L+ E+R + V
Sbjct: 248 GLIDEIYGIQNSYVKLPPEKFAPKKQGDGGKDLPTEAKKLQLNSAEELYAEIRDKNFNAV 307
Query: 300 SKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKG 359
+++ + + + + ++ Q + ++P Q + H +A + +K
Sbjct: 308 GSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIA-ELIKDVTT 366
Query: 360 S---VEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYIL---- 412
S +KL +VEQ+ G D +K+ + ++ D + I+VL L L
Sbjct: 367 SEDFFDKL-TVEQEFMSGIDT--DKVNNYIE-------DCIAQKHSLIKVLRLVCLQSVC 416
Query: 413 ---LRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERM--- 466
L+ V + +++Q + H + NLE+ G GG + R+
Sbjct: 417 NSGLKQKVLDYYKREILQTYGYE-HILTLHNLEKAGLLKPQTGGRNNYPTIRKTLRLWMD 475
Query: 467 -----EPT---YQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSD-----PAPTASSQAAVS 513
PT Y S + P + + L R W + + P P + +
Sbjct: 476 DVNEQNPTDISYVYSGYAP-----LSVRLAQLLSRPGWRSIEEVLRILPGPHFEERQPLP 530
Query: 514 ARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTP 573
G K + G E R +++ +GGV +E+ A +++ +G E +I ++ ++
Sbjct: 531 T--GLQKKRQPG-ENRV---TLIFFLGGVTFAEIAALRFLSQLEDGGTEYVIATTKLMNG 584
Query: 574 TRFLDDL 580
T +++ L
Sbjct: 585 TSWIEAL 591
>gi|119829191 vacuolar protein sorting 33B (yeast homolog)) [Homo
sapiens]
Length = 617
Score = 49.7 bits (117), Expect = 8e-06
Identities = 66/296 (22%), Positives = 127/296 (42%), Gaps = 27/296 (9%)
Query: 136 AFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGP 195
+ LP + + S++ P + + E R + +AQ + L +P G
Sbjct: 144 SLLPLDVDLLSMELPE----FFRDYFLEGDQRWINTVAQALHLLSTLYGPFPNCY---GI 196
Query: 196 EDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYD 255
A++A+ + L + D + G PE + ++DR D V+ L ++ ++ + D
Sbjct: 197 GRCAKMAYELWRNLEE-EEDGETKGRRPEI--GHIFLLDRDVDFVTALCSQVVYEGLVDD 253
Query: 256 LLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADV----SKKVTELLRTFC 311
I+ + + S + VLL+ +D ++ E+R+ H ++V S+K L +
Sbjct: 254 TFRIKCGSVDFGPEVTSSDKSLKVLLNAEDKVFNEIRNEHFSNVFGFLSQKARNLQAQY- 312
Query: 312 ESKRLTTDKANIKD-LSQILKKMPQYQKELNKYSTHLHLADDCM-KHFKGSVEKLCSVEQ 369
+R D +K+ +SQ LK + Q + L S H+ + M K K ++L E
Sbjct: 313 -DRRRGMDIKQMKNFVSQELKGLKQEHRLL---SLHIGACESIMKKKTKQDFQELIKTEH 368
Query: 370 DLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKL 425
L EG I++S I +D V + +R++ L + NG+ ++ L
Sbjct: 369 AL-----LEGFNIRESTSYI-EEHIDRQVSPIESLRLMCLLSITENGLIPKDYRSL 418
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 35.4 bits (80), Expect = 0.15
Identities = 55/234 (23%), Positives = 108/234 (46%), Gaps = 23/234 (9%)
Query: 116 SELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQ 175
SEL R L +V++ L+EI + + VF +Y+L R ++ +++ +
Sbjct: 327 SELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDL--KGRLDDIRMEMDDFNEV 384
Query: 176 IATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDR 235
L T+++ A P + L H +L + N ++A P + E+ SQ+++
Sbjct: 385 FQILLNTVKDSKA-----EPHFLSILQHLLLVR-NDYEA-RPQYYKLIEECISQIVLHKN 437
Query: 236 AADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDED----DDLWVEL 291
ADP H Q L+D D + E + ++A E LD + +L VE+
Sbjct: 438 GADPDFKCRH---LQIEIEGLIDQMIDKTKVEKSE-AKAAELEKKLDSELTARHELQVEM 493
Query: 292 RHMHIADVSKKVTELL----RTFCESKRLTTDKANIK-DLSQILKKMPQYQKEL 340
+ M +D +K+ +L E +++ T+K +++ ++SQ+ ++ + KEL
Sbjct: 494 KKME-SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKEL 546
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 35.4 bits (80), Expect = 0.15
Identities = 55/234 (23%), Positives = 108/234 (46%), Gaps = 23/234 (9%)
Query: 116 SELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQ 175
SEL R L +V++ L+EI + + VF +Y+L R ++ +++ +
Sbjct: 336 SELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDL--KGRLDDIRMEMDDFNEV 393
Query: 176 IATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDR 235
L T+++ A P + L H +L + N ++A P + E+ SQ+++
Sbjct: 394 FQILLNTVKDSKA-----EPHFLSILQHLLLVR-NDYEA-RPQYYKLIEECISQIVLHKN 446
Query: 236 AADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDED----DDLWVEL 291
ADP H Q L+D D + E + ++A E LD + +L VE+
Sbjct: 447 GADPDFKCRH---LQIEIEGLIDQMIDKTKVEKSE-AKAAELEKKLDSELTARHELQVEM 502
Query: 292 RHMHIADVSKKVTELL----RTFCESKRLTTDKANIK-DLSQILKKMPQYQKEL 340
+ M +D +K+ +L E +++ T+K +++ ++SQ+ ++ + KEL
Sbjct: 503 KKME-SDFEQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKEL 555
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 34.7 bits (78), Expect = 0.25
Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 19/119 (15%)
Query: 253 AYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCE 312
AY+L+ + + E EK +LL E + L++EL+H+ + E L+ +
Sbjct: 723 AYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY-- 780
Query: 313 SKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDL 371
+ + D Q LK + ELN Y K +K VEKL + Q+L
Sbjct: 781 -------RRTLHDKKQQLKVL---SSELNMYEVQ-------SKEYKYEVEKLTNELQNL 822
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 32.7 bits (73), Expect = 0.97
Identities = 25/91 (27%), Positives = 46/91 (50%), Gaps = 6/91 (6%)
Query: 303 VTELLRTFCESKRLTTDKA----NIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFK 358
VT + T + K L TD A +I DL Q++K+ + ++++NKY+ L +KH
Sbjct: 2271 VTRMYET--KLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVP 2328
Query: 359 GSVEKLCSVEQDLAMGSDAEGEKIKDSMKLI 389
E ++++L + A + K+ +LI
Sbjct: 2329 EGAETEQGLKRELQVLRLANHQLDKEKAELI 2359
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 32.3 bits (72), Expect = 1.3
Identities = 54/226 (23%), Positives = 94/226 (41%), Gaps = 24/226 (10%)
Query: 161 RAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAK------LNAFKA 214
RAE R+ E A +A E R+ + A + + +K ++ +
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 215 DTPSLGEGPEKTRSQL--LIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLS 272
+L + E+ R+QL L + A + L E+ QAM E+D +T
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK---AQFERDL---QTRDEQ 1586
Query: 273 EAREKAVLLDEDDDLWVEL----RHMHIADVSKKVTELLRTFCESKRLTTDKAN---IKD 325
+K +L+ + +L EL + +A SKK E+ E++ +KA IK
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 326 LSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDL 371
L ++ +M YQ+EL + D+ K S +KL S+E ++
Sbjct: 1647 LRKLQAQMKDYQRELEEARAS---RDEIFAQSKESEKKLKSLEAEI 1689
>gi|88999601 tripartite motif-containing 69 isoform a [Homo sapiens]
Length = 500
Score = 32.3 bits (72), Expect = 1.3
Identities = 70/308 (22%), Positives = 118/308 (38%), Gaps = 47/308 (15%)
Query: 294 MHIADVSKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDC 353
+ I+D TE L + +L T ++ L + K+ KE NK LHL
Sbjct: 151 LQISDAVHFFTEELAI--QQGQLETTLKELQTLRNMQKEAIAAHKE-NK----LHLQQHV 203
Query: 354 MKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILL 413
F + L S E+D+ EG+ + + M+L + L + + A D + + +
Sbjct: 204 SMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKD------MLVSI 257
Query: 414 RNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLS 473
+ ++N ++ ++L+ +LEQ G V L RE + L
Sbjct: 258 QAKTEQQNSFDFLKDI-----TTLLHSLEQ-GMKV-----------LATRELISRKLNLG 300
Query: 474 RWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPR 533
++ I+ ++ ++D L L P DP + ++ WH + I R
Sbjct: 301 QYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPER 360
Query: 534 L--IVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHI-------LTP--------TRF 576
V V+G + + +EV A + KW V + I LTP R
Sbjct: 361 FDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRN 420
Query: 577 LDDLKALD 584
DLKALD
Sbjct: 421 QTDLKALD 428
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
[Homo sapiens]
Length = 1235
Score = 32.0 bits (71), Expect = 1.6
Identities = 25/79 (31%), Positives = 37/79 (46%), Gaps = 7/79 (8%)
Query: 293 HMHIADVSKKVTELLRTFCESKRLTTDKANIKDLSQIL-KKMPQYQKELNKYSTHLHLAD 351
H +I KK +L +++L + +K + +L +K PQY K S HL D
Sbjct: 259 HENIVKARKKEHGML-----TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD 313
Query: 352 DCMKHFKGSVEKLCSVEQD 370
K K S EK CS ++D
Sbjct: 314 VAKKSIKDS-EKQCSKQED 331
>gi|37595541 tripartite motif-containing 69 isoform b [Homo sapiens]
Length = 341
Score = 31.6 bits (70), Expect = 2.2
Identities = 63/282 (22%), Positives = 109/282 (38%), Gaps = 42/282 (14%)
Query: 320 KANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEG 379
+ +K+L Q L+ M + +K LHL F + L S E+D+ EG
Sbjct: 13 ETTLKEL-QTLRNMQKEAIAAHK-ENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEG 70
Query: 380 EKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIR 439
+ + + M+L + L + + A D + + ++ ++N ++ ++L+
Sbjct: 71 KALNEEMELNLSQLQEQCLLAKD------MLVSIQAKTEQQNSFDFLKDI-----TTLLH 119
Query: 440 NLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFV 499
+LEQ G V L RE + L ++ I+ ++ ++D L L P
Sbjct: 120 SLEQ-GMKV-----------LATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLT 167
Query: 500 SDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRL--IVYVMGGVAMSEMRAAYEVTRAT 557
DP + ++ WH + I R V V+G + + +EV A
Sbjct: 168 LDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAK 227
Query: 558 EGKWEVLIGSSHI-------LTP--------TRFLDDLKALD 584
+ KW V + I LTP R DLKALD
Sbjct: 228 KTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALD 269
>gi|117414154 sodium channel associated protein 2 isoform b [Homo
sapiens]
Length = 939
Score = 31.2 bits (69), Expect = 2.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 247 LTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVL-LDEDDDLWVELRHMHIADVSKKVTE 305
+ Q A + L D ++ + + EA + + L + ++ ++ + + K++ E
Sbjct: 850 IELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 909
Query: 306 LLRTFCESKRLTTDKANIKDLSQILKKMPQ 335
LL C++K+ T +A IK L+ L ++ Q
Sbjct: 910 LLEETCKNKK--TMEAKIKQLAFALNEIQQ 937
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 31.2 bits (69), Expect = 2.8
Identities = 20/90 (22%), Positives = 44/90 (48%), Gaps = 3/90 (3%)
Query: 247 LTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVL-LDEDDDLWVELRHMHIADVSKKVTE 305
+ Q A + L D ++ + + EA + + L + ++ ++ + + K++ E
Sbjct: 943 IELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 1002
Query: 306 LLRTFCESKRLTTDKANIKDLSQILKKMPQ 335
LL C++K+ T +A IK L+ L ++ Q
Sbjct: 1003 LLEETCKNKK--TMEAKIKQLAFALNEIQQ 1030
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 30.8 bits (68), Expect = 3.7
Identities = 57/246 (23%), Positives = 97/246 (39%), Gaps = 27/246 (10%)
Query: 138 LPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPED 197
L YE Q LD N + R E+ TRQL Q T+ + ++ A + +
Sbjct: 1024 LEYEKQSEQLDVEKERANNF-EHRIEDLTRQLRNSTLQCETINSDNEDLLA--RIETLQS 1080
Query: 198 TAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLL 257
A+L + ++ KA E EK + + I + A L EL Q
Sbjct: 1081 NAKLLEVQILEVQRAKAMVDKELEA-EKLQKEQKIKEHATTVNE--LEELQVQLQK---- 1133
Query: 258 DIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLT 317
E L + ++ L+ +D L +M IAD + + EL +++LT
Sbjct: 1134 ---------EKKQLQKTMQELELVKKDAQQ-TTLMNMEIADYERLMKEL------NQKLT 1177
Query: 318 TDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEK-LCSVEQDLAMGSD 376
I+DL Q +K Q Q+ L + T L + + +++ L +++LA
Sbjct: 1178 NKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQ 1237
Query: 377 AEGEKI 382
AE + +
Sbjct: 1238 AETDHL 1243
>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 30.8 bits (68), Expect = 3.7
Identities = 25/100 (25%), Positives = 49/100 (49%), Gaps = 11/100 (11%)
Query: 291 LRHMHIADVSKKVTELLRTFC---ESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHL 347
++H+++ +SK VT L + C ESK K I D +++P +K+L K+
Sbjct: 1080 IKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVD-RLFEQQLPDMKKKLWKF---- 1134
Query: 348 HLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMK 387
DD + + ++K+ V + G D++ K++ + K
Sbjct: 1135 --VDDQLDYLFAKLKKIL-VCDSKSFGRDSDEGKLEKTSK 1171
>gi|6912288 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 30.8 bits (68), Expect = 3.7
Identities = 25/100 (25%), Positives = 49/100 (49%), Gaps = 11/100 (11%)
Query: 291 LRHMHIADVSKKVTELLRTFC---ESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHL 347
++H+++ +SK VT L + C ESK K I D +++P +K+L K+
Sbjct: 1080 IKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVD-RLFEQQLPDMKKKLWKF---- 1134
Query: 348 HLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMK 387
DD + + ++K+ V + G D++ K++ + K
Sbjct: 1135 --VDDQLDYLFAKLKKIL-VCDSKSFGRDSDEGKLEKTSK 1171
>gi|212549532 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 30.8 bits (68), Expect = 3.7
Identities = 25/100 (25%), Positives = 49/100 (49%), Gaps = 11/100 (11%)
Query: 291 LRHMHIADVSKKVTELLRTFC---ESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHL 347
++H+++ +SK VT L + C ESK K I D +++P +K+L K+
Sbjct: 1080 IKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVD-RLFEQQLPDMKKKLWKF---- 1134
Query: 348 HLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMK 387
DD + + ++K+ V + G D++ K++ + K
Sbjct: 1135 --VDDQLDYLFAKLKKIL-VCDSKSFGRDSDEGKLEKTSK 1171
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 30.4 bits (67), Expect = 4.8
Identities = 53/242 (21%), Positives = 94/242 (38%), Gaps = 33/242 (13%)
Query: 164 ERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGP 223
E RQL+ Q + A L+E + +G DTA L A L K F+A+ +
Sbjct: 2644 EELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP-AQLQKQQNFQAELDASMHQQ 2702
Query: 224 EKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDE 283
++ + + + + P S + E + A L QD + + L +A E L
Sbjct: 2703 QELQREGQRLLQGGHPASEAIQERLEELGA--LWGELQDNSQKKVAKLQKACEALRLRRS 2760
Query: 284 DDDL--W-----VELRHMHIADVSKKVTELLRTFCESKRLTTDKAN-------------- 322
++L W VELR + V ELL T E + KA
Sbjct: 2761 MEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820
Query: 323 -----IKDLSQ----ILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAM 373
+D+ + +L++ ++ L + T L +K F+ + E++ V++ L +
Sbjct: 2821 EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPL 2880
Query: 374 GS 375
+
Sbjct: 2881 AA 2882
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 30.4 bits (67), Expect = 4.8
Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 13/93 (13%)
Query: 270 GLSEAREKAVLLDEDDDLW--VELRHMHIADVSKKVTELL-----RTFCESKRLTTDKA- 321
GLSE + + L DDL +E+ + + K+ E +T ES L + K
Sbjct: 268 GLSEVKSE---LQSRDDLLRIIEMERLQLHRELLKIGECQNAQGNKTRLESSYLPSIKEP 324
Query: 322 --NIKDLSQILKKMPQYQKELNKYSTHLHLADD 352
IK+L +++ P ++KELNK + L ++
Sbjct: 325 ERKIKELFSVMQDQPNHEKELNKIRSQLQQVEE 357
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 30.0 bits (66), Expect = 6.3
Identities = 44/220 (20%), Positives = 93/220 (42%), Gaps = 21/220 (9%)
Query: 161 RAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPE-DTAQLAHAVLAKLNAFKADTPSL 219
RA+ +L L Q++A T Q+ A + + + AH +LA+ N + +L
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 220 G---------EGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTG 270
G + EK +L + A+ L E+ +A + ++E T +YE
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAET---RLAEVQREAQS-TARELEVMTAKYEGAK 1516
Query: 271 LSEAREKAVLLDEDDDLWVELRHMHI--ADVSKKVTELLRTFCESKRLT-TDKANIKDLS 327
+ E+ +E L ++ + + + +K+V EL + +S + + + +K +
Sbjct: 1517 VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
Query: 328 ----QILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEK 363
+ ++ + Q +LN+ L + +H+K +EK
Sbjct: 1577 AQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616
>gi|154813191 IQ motif containing E isoform 1 [Homo sapiens]
Length = 695
Score = 30.0 bits (66), Expect = 6.3
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 5/56 (8%)
Query: 163 EERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPS 218
EER + EVL ++I TL + LQE ++ ++ ED ++ H K A TPS
Sbjct: 440 EERREREEVLREEIQTLTSKLQELQEMK-KEEKEDCPEVPH----KAQELPAPTPS 490
>gi|154813193 IQ motif containing E isoform 2 [Homo sapiens]
Length = 679
Score = 30.0 bits (66), Expect = 6.3
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 5/56 (8%)
Query: 163 EERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPS 218
EER + EVL ++I TL + LQE ++ ++ ED ++ H K A TPS
Sbjct: 424 EERREREEVLREEIQTLTSKLQELQEMK-KEEKEDCPEVPH----KAQELPAPTPS 474
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 29.6 bits (65), Expect = 8.2
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 366 SVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKL 425
+VE LA+ + + ++DS K P+ L A +Y+ ++LL + R ++L +L
Sbjct: 1951 NVEATLALLKNGANKDMQDS-KEETPLFLAAREGSYEAAKLLLDHFANRE--ITDHLDRL 2007
Query: 426 IQH-ANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEP 462
+ A + H ++R L+Q G + PG G L P
Sbjct: 2008 PRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCP 2045
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,335,953
Number of Sequences: 37866
Number of extensions: 916516
Number of successful extensions: 2663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2631
Number of HSP's gapped (non-prelim): 36
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.