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Search of human proteins with 188219625
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188219625 signal transducing adaptor molecule 2 [Homo
sapiens]
(525 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 1056 0.0
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 561 e-160
gi|209180457 target of myb1 isoform 2 [Homo sapiens] 101 2e-21
gi|4885637 target of myb1 isoform 1 [Homo sapiens] 101 2e-21
gi|131888135 target of myb1-like 2 isoform 3 [Homo sapiens] 97 5e-20
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su... 96 8e-20
gi|209180448 target of myb1 isoform 3 [Homo sapiens] 82 1e-15
gi|191252812 target of myb1-like 1 [Homo sapiens] 81 3e-15
gi|209180450 target of myb1 isoform 4 [Homo sapiens] 81 3e-15
gi|20336267 ADP-ribosylation factor binding protein 3 isoform lo... 76 9e-14
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 71 2e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 67 3e-11
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 67 5e-11
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 67 5e-11
gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens] 65 2e-10
gi|9558729 golgi associated, gamma adaptin ear containing, ARF b... 61 3e-09
gi|48527952 golgi associated, gamma adaptin ear containing, ARF ... 61 3e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 60 4e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 57 3e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 57 3e-08
gi|166235148 osteoclast stimulating factor 1 [Homo sapiens] 57 4e-08
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 57 4e-08
gi|11321634 CD2-associated protein [Homo sapiens] 56 7e-08
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 56 9e-08
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 56 9e-08
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 56 9e-08
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 56 9e-08
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 56 9e-08
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 56 9e-08
gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens] 55 2e-07
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 1056 bits (2730), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH 60
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH
Sbjct: 1 MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH 60
Query: 61 VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF 120
VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF
Sbjct: 61 VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF 120
Query: 121 QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQE 180
QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQE
Sbjct: 121 QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQE 180
Query: 181 QKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWW 240
QKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWW
Sbjct: 181 QKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWW 240
Query: 241 KGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRA 300
KGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRA
Sbjct: 241 KGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRA 300
Query: 301 LQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALEL 360
LQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALEL
Sbjct: 301 LQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALEL 360
Query: 361 YNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSL 420
YNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSL
Sbjct: 361 YNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQSIHQVTVAQSYSL 420
Query: 421 GPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQ 480
GPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQ
Sbjct: 421 GPDQIGPLRSLPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNSNLQSATGTTAYTQQ 480
Query: 481 MGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL 525
MGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL
Sbjct: 481 MGMSVDMSSYQNTTSNLPQLAGFPVTVPAHPVAQQHTNYHQQPLL 525
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 561 bits (1446), Expect = e-160
Identities = 301/539 (55%), Positives = 371/539 (68%), Gaps = 22/539 (4%)
Query: 1 MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH 60
MPLF NPF+QDVEKAT+E NT EDW LI+DICDKVG + G KDCL++IM+RVNHK PH
Sbjct: 1 MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH 60
Query: 61 VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF 120
VA+QALTLLGACV+NCGKIFHLEVCSRDFA+EV V+ NK HPKVCEKLK+LMVEW++EF
Sbjct: 61 VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL-NKGHPKVCEKLKALMVEWTDEF 119
Query: 121 QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKN--------GTSSNKNKEDEDIAK 172
+ DPQ SLISA IK++KE+G+TFP GSQ A + GT +NK KE+ED+AK
Sbjct: 120 KNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANK-KEEEDLAK 178
Query: 173 AIELSLQEQKQQHTETKSLYPSSEIQLNN--KVARKVRALYDFEAVEDNELTFKHGEIII 230
AIELSL+EQ+QQ T +LYPS+ L N RKVRA+YDFEA EDNELTFK GEII
Sbjct: 179 AIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIIT 238
Query: 231 VLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNV-IDDDVE-EIKKSEPE 288
VLDDSD NWWKGE H+GIGLFPSNFVT +L E E +K V DDV+ E + EPE
Sbjct: 239 VLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPE 298
Query: 289 PVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELS 348
P +IDEDKMD+ LQ+LQS DP+D +PD +LL LE +C QMGP+IDEKLE+IDRKHSELS
Sbjct: 299 PAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELS 358
Query: 349 ELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQS 408
ELNVKV+EAL LY KL+NE P+YS+Y+KL +Y +S Q Y G Y+
Sbjct: 359 ELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAG 418
Query: 409 IHQVTVAQSYSLGPDQIGPLRS--LPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNS 466
Q++ QSYSL P+Q+ L +PP+ N ++ +Q Q +Y +T +V TY +Q
Sbjct: 419 NAQMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAP 478
Query: 467 NLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPA--HPVAQQHTNYHQQP 523
TA + D++ YQN N+PQ+ + +T P Q QQP
Sbjct: 479 VYSPPPAATA----AAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQP 533
>gi|209180457 target of myb1 isoform 2 [Homo sapiens]
Length = 493
Score = 101 bits (251), Expect = 2e-21
Identities = 64/194 (32%), Positives = 97/194 (50%), Gaps = 9/194 (4%)
Query: 1 MPLFTANPFE----QDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKR-VN 55
M NPF Q +EKAT+ +EDW+L M+ICD + T G KD L+A+ KR V
Sbjct: 1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVG 60
Query: 56 HKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATE--VRAVI-KNKAHPKVCEKLKSL 112
+K H + ALT+L CV NCG FH+ V S+DF VR ++ KN V +K+ +L
Sbjct: 61 NKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNL 120
Query: 113 MVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAA-AKNGTSSNKNKEDEDIA 171
+ W++ F+ P + + + ++ +G+ FP +S T N + +
Sbjct: 121 IQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDS 180
Query: 172 KAIELSLQEQKQQH 185
+ S QE QH
Sbjct: 181 VGTDSSQQEDSGQH 194
>gi|4885637 target of myb1 isoform 1 [Homo sapiens]
Length = 492
Score = 101 bits (251), Expect = 2e-21
Identities = 64/194 (32%), Positives = 97/194 (50%), Gaps = 9/194 (4%)
Query: 1 MPLFTANPFE----QDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKR-VN 55
M NPF Q +EKAT+ +EDW+L M+ICD + T G KD L+A+ KR V
Sbjct: 1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVG 60
Query: 56 HKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATE--VRAVI-KNKAHPKVCEKLKSL 112
+K H + ALT+L CV NCG FH+ V S+DF VR ++ KN V +K+ +L
Sbjct: 61 NKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNL 120
Query: 113 MVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAA-AKNGTSSNKNKEDEDIA 171
+ W++ F+ P + + + ++ +G+ FP +S T N + +
Sbjct: 121 IQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDS 180
Query: 172 KAIELSLQEQKQQH 185
+ S QE QH
Sbjct: 181 VGTDSSQQEDSGQH 194
>gi|131888135 target of myb1-like 2 isoform 3 [Homo sapiens]
Length = 507
Score = 96.7 bits (239), Expect = 5e-20
Identities = 56/160 (35%), Positives = 86/160 (53%), Gaps = 8/160 (5%)
Query: 1 MPLFTANPFE----QDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVN- 55
M NPF Q +EKAT+ +EDW+L M+ICD + T G KD ++A+ KR+N
Sbjct: 1 MEFLLGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNG 60
Query: 56 HKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVI---KNKAHPKVCEKLKSL 112
++ + ALT+L CV NCG FH+ V +RDF V I KN V +K+ +L
Sbjct: 61 NRNYREVMLALTVLETCVKNCGHRFHILVANRDFIDSVLVKIISPKNNPPTIVQDKVLAL 120
Query: 113 MVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVS 152
+ W++ F+ P + + + +K +G+ FP A +S
Sbjct: 121 IQAWADAFRSSPDLTGVVHIYEELKRKGVEFPMADLDALS 160
>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
substrate [Homo sapiens]
Length = 777
Score = 95.9 bits (237), Expect = 8e-20
Identities = 47/136 (34%), Positives = 78/136 (57%)
Query: 9 FEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTL 68
FE+ ++KAT++ DW I+ ICD + AK + +I K+VN K PHVAL AL +
Sbjct: 8 FERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEV 67
Query: 69 LGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSL 128
+ + V NCG+ H EV ++ E++ ++K + V K+ L+ W+ F+ +P++ +
Sbjct: 68 MESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKV 127
Query: 129 ISATIKSMKEEGITFP 144
+ T + MK EG FP
Sbjct: 128 VQDTYQIMKVEGHVFP 143
>gi|209180448 target of myb1 isoform 3 [Homo sapiens]
Length = 460
Score = 82.0 bits (201), Expect = 1e-15
Identities = 51/161 (31%), Positives = 80/161 (49%), Gaps = 5/161 (3%)
Query: 30 MDICDKVGSTPNGAKDCLKAIMKR-VNHKVPHVALQALTLLGACVANCGKIFHLEVCSRD 88
M+ICD + T G KD L+A+ KR V +K H + ALT+L CV NCG FH+ V S+D
Sbjct: 1 MEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQD 60
Query: 89 FATE--VRAVI-KNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPP 145
F VR ++ KN V +K+ +L+ W++ F+ P + + + ++ +G+ FP
Sbjct: 61 FVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPM 120
Query: 146 AGSQTVSAA-AKNGTSSNKNKEDEDIAKAIELSLQEQKQQH 185
+S T N + + + S QE QH
Sbjct: 121 TDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQH 161
>gi|191252812 target of myb1-like 1 [Homo sapiens]
Length = 476
Score = 80.9 bits (198), Expect = 3e-15
Identities = 85/356 (23%), Positives = 155/356 (43%), Gaps = 46/356 (12%)
Query: 13 VEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQ-ALTLLGA 71
+EKAT TEDW M ICD + +T +G KD +KA+ KR++ H +Q L+L+
Sbjct: 19 IEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDM 78
Query: 72 CVANCGKIFHLEVCSRDFATEVRAVIKNKAHP---KVCEKLKSLMVEWSEEFQKDPQFSL 128
CV NCG F + ++F E + N + + ++ + + WS+ F S
Sbjct: 79 CVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSE 138
Query: 129 ISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTET 188
+ + ++G+ FPP+ ++ +A + S+ A A+ + + T
Sbjct: 139 VKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPK----NST 194
Query: 189 KSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGI 248
+L P +L++ + + V+ N I+++++ + ENH I
Sbjct: 195 VTLVPEQIGKLHS----------ELDMVKMNVRVMS----AILMENTPGS----ENHEDI 236
Query: 249 GLFPSNFVTTNLNIETEAAAVDKLNVIDDD---VEEIKKSEP-EPVYIDEDKMDRALQVL 304
L + T E + +D L V++++ VE I+ +E + ++ R Q +
Sbjct: 237 ELLQKLYKTGR---EMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRI 293
Query: 305 -------QSIDPTDSKPD--SQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELN 351
+ T S+P SQDLLDL + M L E++ +++LS LN
Sbjct: 294 LEQNKNQKEATNTTSEPSAPSQDLLDLSPSPR----MPRATLGELNTMNNQLSGLN 345
>gi|209180450 target of myb1 isoform 4 [Homo sapiens]
Length = 447
Score = 80.9 bits (198), Expect = 3e-15
Identities = 50/121 (41%), Positives = 69/121 (57%), Gaps = 8/121 (6%)
Query: 1 MPLFTANPFE----QDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKR-VN 55
M NPF Q +EKAT+ +EDW+L M+ICD + T G KD L+A+ KR V
Sbjct: 1 MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVG 60
Query: 56 HKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATE--VRAVI-KNKAHPKVCEKLKSL 112
+K H + ALT+L CV NCG FH+ V S+DF VR ++ KN V +K+ +L
Sbjct: 61 NKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNL 120
Query: 113 M 113
+
Sbjct: 121 I 121
>gi|20336267 ADP-ribosylation factor binding protein 3 isoform long
[Homo sapiens]
Length = 723
Score = 75.9 bits (185), Expect = 9e-14
Identities = 95/400 (23%), Positives = 158/400 (39%), Gaps = 53/400 (13%)
Query: 10 EQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLL 69
E + KATN N EDW I+ CD++ G + ++ + ++ ALQALT+L
Sbjct: 10 ESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVL 69
Query: 70 GACVANCGKIFHLEVCSRDFATEVRAVIKNK-AHPKVCEKLKSLMVE----WSEEFQKDP 124
AC+ NCG+ FH EV F E+ V+ K +V EK+K+ ++E W+ P
Sbjct: 70 EACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMAL---P 126
Query: 125 QFSLISATIKSMKEEGI--TFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQK 182
+ + I +K +GI + PP + N +DE+ +K + L+ +
Sbjct: 127 EEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKN 186
Query: 183 QQH-TETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWK 241
E L S + ++ + + L+ E V +N E+++ D++
Sbjct: 187 PDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLL--SEMLLHYSQEDSS--D 242
Query: 242 GENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRAL 301
G+ LF + + D N + D ++ S+ I+ K
Sbjct: 243 GDRELMKELFDQCENKRRTLFKLASETEDNDNSLGD---ILQASDNLSRVINSYKTIIEG 299
Query: 302 QVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELY 361
QV+ T + PDS+ C G +ID L E+D +S
Sbjct: 300 QVINGEVATLTLPDSEG----NSQCSNQGTLID--LAELDTTNS---------------- 337
Query: 362 NKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHG 401
S + PA PP SSG+P+ P Q+ G
Sbjct: 338 ------------LSSVLAPAPTPP-SSGIPILPPPPQASG 364
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 71.2 bits (173), Expect = 2e-12
Identities = 34/82 (41%), Positives = 50/82 (60%), Gaps = 7/82 (8%)
Query: 175 ELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDD 234
E++ ++HT+ L + + R RALYDFEA+ED+EL F GE++ VLD
Sbjct: 251 EMNAALMHRRHTDPVQLQAAGRV-------RWARALYDFEALEDDELGFHSGEVVEVLDS 303
Query: 235 SDANWWKGENHRGIGLFPSNFV 256
S+ +WW G H +GLFP+N+V
Sbjct: 304 SNPSWWTGRLHNKLGLFPANYV 325
Score = 34.3 bits (77), Expect = 0.29
Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
A +DF A ++EL+F G+++ +L + + W+K E G P NF+
Sbjct: 5 AKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 67.4 bits (163), Expect = 3e-11
Identities = 46/164 (28%), Positives = 80/164 (48%), Gaps = 16/164 (9%)
Query: 206 KVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETE 265
+V +YD+ A D+EL F G+II VL+ D +WWKGE + +GLFPSN+V +++
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPS 1218
Query: 266 AAAVDKLNVID--DDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLE 323
L+++D E ++ + + E+ LQ++ I KP + L
Sbjct: 1219 QQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEI---FQKPLMESEL--- 1272
Query: 324 DICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYNKLVNE 367
+ ++++ I EL N+K+L+AL + K+ E
Sbjct: 1273 --------LTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGE 1308
Score = 46.6 bits (109), Expect = 6e-05
Identities = 20/48 (41%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
A+Y +E+ E +LTF+ G++I+V D +WW G G+FPSN+V
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYV 1055
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 193 PSSEIQLNNKV-ARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLF 251
PS + KV + +ALY + A +DN L F ++I VL+ D WW GE G F
Sbjct: 903 PSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWF 961
Query: 252 PSNFV 256
P ++V
Sbjct: 962 PKSYV 966
Score = 36.2 bits (82), Expect = 0.075
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE-----NHRGIGLFPSNFV 256
+ + + A +LT G++I++ + WW+GE R IG FP+N+V
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Score = 35.8 bits (81), Expect = 0.099
Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 152 SAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKV---R 208
S K+G K + + + + + K S + ++ + KV R
Sbjct: 687 SVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYR 746
Query: 209 ALYDFEAVEDNELTFKHGEIIIV----LDDS---DANWWKGENHRGIGLFPSNF 255
ALY FE+ +E+T + G+I++V +D+S + W GE G FP+N+
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY 800
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 66.6 bits (161), Expect = 5e-11
Identities = 30/57 (52%), Positives = 40/57 (70%), Gaps = 1/57 (1%)
Query: 207 VRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVT-TNLNI 262
V+AL+DF+ ED EL F+ G+ I V+D+SD NWWKG H G+FP N+VT N N+
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 217
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/49 (44%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVL-DDSDANWWKGENHRGIGLFPSNFV 256
A YDF+A D+EL+FK G+I+ VL ++ D NW+K E + G P N++
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 66.6 bits (161), Expect = 5e-11
Identities = 30/57 (52%), Positives = 40/57 (70%), Gaps = 1/57 (1%)
Query: 207 VRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVT-TNLNI 262
V+AL+DF+ ED EL F+ G+ I V+D+SD NWWKG H G+FP N+VT N N+
Sbjct: 120 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 176
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/49 (44%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVL-DDSDANWWKGENHRGIGLFPSNFV 256
A YDF+A D+EL+FK G+I+ VL ++ D NW+K E + G P N++
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
>gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens]
Length = 613
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/226 (25%), Positives = 105/226 (46%), Gaps = 30/226 (13%)
Query: 13 VEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGAC 72
+ KAT+ + +DWS I + C++V + PNG + ++ AL ALT+L C
Sbjct: 30 LNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMC 89
Query: 73 VANCGKIFHLEVCSRDFATEVRAVIKNK-----AHPKVCEKLKSLMVEWSEEFQKDPQFS 127
+ +CG+ FH EV F E+ V+ K A KV ++ ++ W+ F +D +
Sbjct: 90 MNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIK-- 147
Query: 128 LISATIKSMKEEGI-----------TFPPAGSQTVSA-------AAKNGTSSNKNKEDED 169
I + +K++GI PP S+ +K T K+ ED
Sbjct: 148 -IRDAYQMLKKQGIIKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPED 206
Query: 170 IAKAIEL--SLQEQKQQHTE--TKSLYPSSEIQLNNKVARKVRALY 211
+ A L +L +++Q+ +E +K + E++ + KV +++ ++Y
Sbjct: 207 LQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMY 252
>gi|9558729 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 1 [Homo sapiens]
Length = 639
Score = 60.8 bits (146), Expect = 3e-09
Identities = 53/226 (23%), Positives = 95/226 (42%), Gaps = 27/226 (11%)
Query: 2 PLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHV 61
P E + +ATN N DW+ I C+++ G + + ++
Sbjct: 3 PAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWE 62
Query: 62 ALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIK-----NKAHPKVCEKLKSLMVEW 116
A+QALT+L C+ +CGK FH EV F E+ V+ ++ KV K+ L+ W
Sbjct: 63 AIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSW 122
Query: 117 SEEFQKDPQFSLISATIKSMKEEGI-----------TFPPAGSQTVSAAAKNGTSSN--- 162
+ P+ I+ + +K++GI TFP + + ++ S
Sbjct: 123 TVGL---PEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLA 179
Query: 163 ---KNKEDEDIAKAIEL--SLQEQKQQHTETKSLYPSSEIQLNNKV 203
K+ ED+ A +L + ++ Q+ E S ++ ++NN V
Sbjct: 180 RLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNV 225
>gi|48527952 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 2 [Homo sapiens]
Length = 552
Score = 60.8 bits (146), Expect = 3e-09
Identities = 53/226 (23%), Positives = 95/226 (42%), Gaps = 27/226 (11%)
Query: 2 PLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHV 61
P E + +ATN N DW+ I C+++ G + + ++
Sbjct: 3 PAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWE 62
Query: 62 ALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIK-----NKAHPKVCEKLKSLMVEW 116
A+QALT+L C+ +CGK FH EV F E+ V+ ++ KV K+ L+ W
Sbjct: 63 AIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSW 122
Query: 117 SEEFQKDPQFSLISATIKSMKEEGI-----------TFPPAGSQTVSAAAKNGTSSN--- 162
+ P+ I+ + +K++GI TFP + + ++ S
Sbjct: 123 TVGL---PEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLA 179
Query: 163 ---KNKEDEDIAKAIEL--SLQEQKQQHTETKSLYPSSEIQLNNKV 203
K+ ED+ A +L + ++ Q+ E S ++ ++NN V
Sbjct: 180 RLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNV 225
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 60.5 bits (145), Expect = 4e-09
Identities = 28/58 (48%), Positives = 41/58 (70%), Gaps = 2/58 (3%)
Query: 206 KVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV--TTNLN 261
+V +YD+ A D+EL F G+II VL+ D +WWKGE + +GLFPSN+V TT+++
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMD 1216
Score = 46.6 bits (109), Expect = 6e-05
Identities = 20/48 (41%), Positives = 31/48 (64%), Gaps = 1/48 (2%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
A+Y +E+ E +LTF+ G++I+V D +WW G G+FPSN+V
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTK-KDGDWWTGTVGDKAGVFPSNYV 1055
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/65 (36%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 193 PSSEIQLNNKV-ARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLF 251
PS + KV + +ALY + A +DN L F ++I VL+ D WW GE G F
Sbjct: 903 PSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWF 961
Query: 252 PSNFV 256
P ++V
Sbjct: 962 PKSYV 966
Score = 36.2 bits (82), Expect = 0.075
Identities = 16/54 (29%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE-----NHRGIGLFPSNFV 256
+ + + A +LT G++I++ + WW+GE R IG FP+N+V
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Score = 35.8 bits (81), Expect = 0.099
Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 152 SAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKV---R 208
S K+G K + + + + + K S + ++ + KV R
Sbjct: 687 SVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYR 746
Query: 209 ALYDFEAVEDNELTFKHGEIIIV----LDDS---DANWWKGENHRGIGLFPSNF 255
ALY FE+ +E+T + G+I++V +D+S + W GE G FP+N+
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANY 800
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/205 (23%), Positives = 91/205 (44%), Gaps = 30/205 (14%)
Query: 175 ELSLQEQKQQHTETKSLYPSSEIQLNNKVARK----------VRALYDFEAVEDNELTFK 224
EL + +K+Q K +P+S ++L + + V A+YD+ A ++EL+F
Sbjct: 1067 ELQARGKKRQ----KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1122
Query: 225 HGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVID--DDVEEI 282
G++I V++ D +WW+GE + GLFPSN+V + + L +D +E
Sbjct: 1123 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERK 1182
Query: 283 KKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDR 342
++ + E++ LQ++ + + + G + + ++ I
Sbjct: 1183 RQGYIHELIQTEERYMADLQLVVEV--------------FQKRMAESGFLTEGEMALIFV 1228
Query: 343 KHSELSELNVKVLEALELYNKLVNE 367
EL N K+L+AL + K E
Sbjct: 1229 NWKELIMSNTKLLKALRVRKKTGGE 1253
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 26/170 (15%)
Query: 134 KSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQ-----EQKQQHTET 188
K++ + PP S + ++ + SSN+ D +L ++K T T
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT 855
Query: 189 KSLYPSSEIQLNNKVAR--KVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHR 246
S S I +V K +AL + A +DN L F +II VL+ + NWW GE H
Sbjct: 856 VSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHG 914
Query: 247 GIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDK 296
G G FP ++V +I E+K+ EPE +Y +K
Sbjct: 915 GRGWFPKSYV----------------KIIPG--SEVKREEPEALYAAVNK 946
Score = 46.2 bits (108), Expect = 7e-05
Identities = 23/54 (42%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 203 VARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
V + ALY + +VE +LTF GE I+V D WW G G+FPSN+V
Sbjct: 955 VGEEYIALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1007
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/128 (28%), Positives = 55/128 (42%), Gaps = 12/128 (9%)
Query: 156 KNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKS----------LYPSSEIQLNNKVAR 205
+N N KE+E+ K ++ ++K Q E K+ L + + V
Sbjct: 674 ENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLV 733
Query: 206 KVRALYDFEAVEDNELTFKHGEIIIVLDDS--DANWWKGENHRGIGLFPSNFVTTNLNIE 263
RALY FEA +E++F G+II V + + + W G G FP N+V + E
Sbjct: 734 NYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 793
Query: 264 TEAAAVDK 271
E A K
Sbjct: 794 NEKAVSPK 801
Score = 32.0 bits (71), Expect = 1.4
Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 187 ETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE--- 243
+ +S +S+ +NK + + A +L+ G++I++L + + WW+GE
Sbjct: 1011 DQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQA 1070
Query: 244 --NHRGIGLFPSNFV 256
R G FP++ V
Sbjct: 1071 RGKKRQKGWFPASHV 1085
Score = 31.6 bits (70), Expect = 1.9
Identities = 28/111 (25%), Positives = 54/111 (48%), Gaps = 13/111 (11%)
Query: 263 ETEAAAVDKLNVIDDDVEEIKKSEPEP-------VYIDEDK--MDRALQVLQSIDPTDSK 313
+TE +DK D ++ EIK+ + E +Y+ +K ++ ++ +Q + DS
Sbjct: 520 KTELEVLDKQ--CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSG 577
Query: 314 PD--SQDLLDLEDICQQMGPMIDEKLEEIDRKHSELSELNVKVLEALELYN 362
+ L+ E++CQ++ +D +E K SE+ N ++ E E YN
Sbjct: 578 VSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYN 628
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 57.4 bits (137), Expect = 3e-08
Identities = 48/205 (23%), Positives = 91/205 (44%), Gaps = 30/205 (14%)
Query: 175 ELSLQEQKQQHTETKSLYPSSEIQLNNKVARK----------VRALYDFEAVEDNELTFK 224
EL + +K+Q K +P+S ++L + + V A+YD+ A ++EL+F
Sbjct: 1094 ELQARGKKRQ----KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1149
Query: 225 HGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVID--DDVEEI 282
G++I V++ D +WW+GE + GLFPSN+V + + L +D +E
Sbjct: 1150 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERK 1209
Query: 283 KKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDR 342
++ + E++ LQ++ + + + G + + ++ I
Sbjct: 1210 RQGYIHELIQTEERYMADLQLVVEV--------------FQKRMAESGFLTEGEMALIFV 1255
Query: 343 KHSELSELNVKVLEALELYNKLVNE 367
EL N K+L+AL + K E
Sbjct: 1256 NWKELIMSNTKLLKALRVRKKTGGE 1280
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 26/170 (15%)
Query: 134 KSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQ-----EQKQQHTET 188
K++ + PP S + ++ + SSN+ D +L ++K T T
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT 882
Query: 189 KSLYPSSEIQLNNKVAR--KVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHR 246
S S I +V K +AL + A +DN L F +II VL+ + NWW GE H
Sbjct: 883 VSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHG 941
Query: 247 GIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDK 296
G G FP ++V +I E+K+ EPE +Y +K
Sbjct: 942 GRGWFPKSYV----------------KIIPG--SEVKREEPEALYAAVNK 973
Score = 46.2 bits (108), Expect = 7e-05
Identities = 23/54 (42%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 203 VARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
V + ALY + +VE +LTF GE I+V D WW G G+FPSN+V
Sbjct: 982 VGEEYIALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1034
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/128 (28%), Positives = 55/128 (42%), Gaps = 12/128 (9%)
Query: 156 KNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKS----------LYPSSEIQLNNKVAR 205
+N N KE+E+ K ++ ++K Q E K+ L + + V
Sbjct: 701 ENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLV 760
Query: 206 KVRALYDFEAVEDNELTFKHGEIIIVLDDS--DANWWKGENHRGIGLFPSNFVTTNLNIE 263
RALY FEA +E++F G+II V + + + W G G FP N+V + E
Sbjct: 761 NYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 820
Query: 264 TEAAAVDK 271
E A K
Sbjct: 821 NEKAVSPK 828
Score = 32.0 bits (71), Expect = 1.4
Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 187 ETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE--- 243
+ +S +S+ +NK + + A +L+ G++I++L + + WW+GE
Sbjct: 1038 DQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQA 1097
Query: 244 --NHRGIGLFPSNFV 256
R G FP++ V
Sbjct: 1098 RGKKRQKGWFPASHV 1112
>gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]
Length = 214
Score = 57.0 bits (136), Expect = 4e-08
Identities = 26/49 (53%), Positives = 32/49 (65%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
RALY FE +EL F+ G+II + D SD NWWKG + GL PSN+V
Sbjct: 18 RALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYV 66
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 57.0 bits (136), Expect = 4e-08
Identities = 31/92 (33%), Positives = 53/92 (57%), Gaps = 14/92 (15%)
Query: 175 ELSLQEQKQQHTETKSLYPSSEIQLNNKVARK----------VRALYDFEAVEDNELTFK 224
EL + +K+Q K +P+S ++L + + V A+YD+ A ++EL+F
Sbjct: 1094 ELQARGKKRQ----KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFS 1149
Query: 225 HGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
G++I V++ D +WW+GE + GLFPSN+V
Sbjct: 1150 KGQLINVMNKDDPDWWQGEINGVTGLFPSNYV 1181
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 26/170 (15%)
Query: 134 KSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQ-----EQKQQHTET 188
K++ + PP S + ++ + SSN+ D +L ++K T T
Sbjct: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT 882
Query: 189 KSLYPSSEIQLNNKVAR--KVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHR 246
S S I +V K +AL + A +DN L F +II VL+ + NWW GE H
Sbjct: 883 VSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHG 941
Query: 247 GIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDK 296
G G FP ++V +I E+K+ EPE +Y +K
Sbjct: 942 GRGWFPKSYV----------------KIIPG--SEVKREEPEALYAAVNK 973
Score = 46.2 bits (108), Expect = 7e-05
Identities = 23/54 (42%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 203 VARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
V + ALY + +VE +LTF GE I+V D WW G G+FPSN+V
Sbjct: 982 VGEEYIALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1034
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/128 (28%), Positives = 55/128 (42%), Gaps = 12/128 (9%)
Query: 156 KNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKS----------LYPSSEIQLNNKVAR 205
+N N KE+E+ K ++ ++K Q E K+ L + + V
Sbjct: 701 ENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLV 760
Query: 206 KVRALYDFEAVEDNELTFKHGEIIIVLDDS--DANWWKGENHRGIGLFPSNFVTTNLNIE 263
RALY FEA +E++F G+II V + + + W G G FP N+V + E
Sbjct: 761 NYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 820
Query: 264 TEAAAVDK 271
E A K
Sbjct: 821 NEKAVSPK 828
Score = 32.0 bits (71), Expect = 1.4
Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 5/75 (6%)
Query: 187 ETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE--- 243
+ +S +S+ +NK + + A +L+ G++I++L + + WW+GE
Sbjct: 1038 DQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQA 1097
Query: 244 --NHRGIGLFPSNFV 256
R G FP++ V
Sbjct: 1098 RGKKRQKGWFPASHV 1112
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 56.2 bits (134), Expect = 7e-08
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 20/138 (14%)
Query: 152 SAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALY 211
S + TSS++ +E + I SL + Q TK+ + + K R L+
Sbjct: 224 SVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKT-----DTEGKIKAKEYCRTLF 278
Query: 212 DFEAVEDNELTFKHGEIIIVL--DDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAV 269
+E ++ELTFK GEII ++ + +A WW+GE + G+FP NF
Sbjct: 279 AYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAV------------ 326
Query: 270 DKLNVIDDDVEEIKKSEP 287
++N +D D + KK P
Sbjct: 327 -QINELDKDFPKPKKPPP 343
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 12/108 (11%)
Query: 183 QQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKG 242
Q H +TK++ ++ R+ + L+++ ++EL K G+II + ++ + WW G
Sbjct: 96 QPHPQTKNIKKKTK-------KRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG 148
Query: 243 ENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPV 290
+ +GLFPSNFV E E + + DD E + P+
Sbjct: 149 TLNNKLGLFPSNFVK-----ELEVTDDGETHEAQDDSETVLAGPTSPI 191
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/56 (44%), Positives = 34/56 (60%), Gaps = 2/56 (3%)
Query: 211 YDFEAVEDNELTFKHGEII-IVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETE 265
YD++AV D+ELT + GEII V + W +GE + G+FP NFV + ETE
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFV-KEIKRETE 62
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 201 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 256
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 257 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 309
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 439 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 489
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 386
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 533 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 588
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 589 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 641
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 771 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 669 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 718
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 370 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 425
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 426 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 478
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 608 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 555
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 440 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 495
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 496 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 548
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 678 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 728
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 576 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 625
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 353 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 408
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 409 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 461
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 591 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 538
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 55.8 bits (133), Expect = 9e-08
Identities = 28/116 (24%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 141 ITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLN 200
+ P + + + + SS +D + ++ +L + + + P E
Sbjct: 375 VDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKE---- 430
Query: 201 NKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
+A+YDF+A EL+FK G+ + +L D NW++GE+H +G+FP ++V
Sbjct: 431 ---KLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 483
Score = 35.8 bits (81), Expect = 0.099
Identities = 16/51 (31%), Positives = 29/51 (56%), Gaps = 2/51 (3%)
Query: 208 RALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRG--IGLFPSNFV 256
+ALY++ ++EL + ++I V++ D W+ G + R G FP N+V
Sbjct: 613 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663
Score = 34.3 bits (77), Expect = 0.29
Identities = 19/52 (36%), Positives = 32/52 (61%), Gaps = 6/52 (11%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGE----NHRGIGLFPSNFV 256
A Y+F A + EL+ + G+ +I+L D NW++G+ N +GI FP ++V
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGI--FPVSYV 560
>gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
Length = 364
Score = 55.1 bits (131), Expect = 2e-07
Identities = 23/48 (47%), Positives = 33/48 (68%)
Query: 209 ALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFV 256
ALY F+A+E ++L F GE I V+DDS+ WW+G+ +G FP NF+
Sbjct: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,080,154
Number of Sequences: 37866
Number of extensions: 883065
Number of successful extensions: 3530
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 3064
Number of HSP's gapped (non-prelim): 590
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.